SH3BP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.90709604
2central nervous system myelination (GO:0022010)4.90709604
3fatty acid elongation (GO:0030497)3.83237767
4pyrimidine nucleobase catabolic process (GO:0006208)3.55090694
5neuron recognition (GO:0008038)3.48019509
6neuron remodeling (GO:0016322)3.43598447
7nucleobase catabolic process (GO:0046113)3.39015281
8cellular response to epinephrine stimulus (GO:0071872)3.34946462
9positive regulation of gamma-delta T cell activation (GO:0046645)3.32638430
10neuron cell-cell adhesion (GO:0007158)3.27856221
11T-helper 1 type immune response (GO:0042088)3.23979497
12negative regulation of protein localization to cell surface (GO:2000009)3.20552615
13response to methylmercury (GO:0051597)3.19740003
14ionotropic glutamate receptor signaling pathway (GO:0035235)3.04419769
15long-chain fatty acid biosynthetic process (GO:0042759)3.02952715
16dendritic spine morphogenesis (GO:0060997)3.02093952
17positive regulation of fibroblast migration (GO:0010763)2.94542587
18positive regulation of type 2 immune response (GO:0002830)2.93958376
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.90533856
20axonal fasciculation (GO:0007413)2.90116864
21detection of molecule of bacterial origin (GO:0032490)2.89448496
22lipopolysaccharide-mediated signaling pathway (GO:0031663)2.89403659
23L-phenylalanine catabolic process (GO:0006559)2.89260704
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.89260704
25glutamate receptor signaling pathway (GO:0007215)2.88975302
26cellular response to growth hormone stimulus (GO:0071378)2.85812248
27negative regulation of neurotransmitter transport (GO:0051589)2.84497140
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74791510
29negative regulation of interleukin-12 production (GO:0032695)2.72623584
30L-amino acid import (GO:0043092)2.72195818
31macrophage activation involved in immune response (GO:0002281)2.71786184
32response to peptidoglycan (GO:0032494)2.69771084
33regulation of T-helper 2 cell differentiation (GO:0045628)2.68883394
34positive regulation by symbiont of host defense response (GO:0052509)2.64626996
35modulation by symbiont of host defense response (GO:0052031)2.64626996
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64626996
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64626996
38positive regulation by organism of defense response of other organism involved in symbiotic interact2.64626996
39modulation by symbiont of host immune response (GO:0052553)2.64626996
40cellular extravasation (GO:0045123)2.63280022
41production of molecular mediator involved in inflammatory response (GO:0002532)2.61479082
42myelination (GO:0042552)2.61418484
43ensheathment of neurons (GO:0007272)2.59531453
44axon ensheathment (GO:0008366)2.59531453
45neutrophil activation involved in immune response (GO:0002283)2.59389443
46positive regulation of endothelial cell apoptotic process (GO:2000353)2.58237758
47leukocyte aggregation (GO:0070486)2.56638262
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.54071538
49response to epinephrine (GO:0071871)2.53299604
50vocalization behavior (GO:0071625)2.51366911
51regulation of collateral sprouting (GO:0048670)2.50305105
52negative regulation of erythrocyte differentiation (GO:0045647)2.48279280
53establishment of mitochondrion localization (GO:0051654)2.48259243
54gamma-aminobutyric acid signaling pathway (GO:0007214)2.47004306
55low-density lipoprotein particle clearance (GO:0034383)2.45906854
56germinal center formation (GO:0002467)2.44783472
57presynaptic membrane organization (GO:0097090)2.44642950
58cholesterol biosynthetic process (GO:0006695)2.44202084
59regulation of ARF protein signal transduction (GO:0032012)2.44122500
60mannose metabolic process (GO:0006013)2.43661694
61regulation of type 2 immune response (GO:0002828)2.43527395
62cellular response to catecholamine stimulus (GO:0071870)2.42558774
63cellular response to monoamine stimulus (GO:0071868)2.42558774
64regulation of glutamate secretion (GO:0014048)2.42309799
65cellular ketone body metabolic process (GO:0046950)2.42091323
66protein localization to synapse (GO:0035418)2.40712133
67regulation of gamma-delta T cell activation (GO:0046643)2.40431417
68positive regulation of Rap GTPase activity (GO:0032854)2.39440891
69positive regulation of cellular amide metabolic process (GO:0034250)2.38731565
70growth hormone receptor signaling pathway (GO:0060396)2.37774514
71detection of external biotic stimulus (GO:0098581)2.36029572
72regulation of B cell receptor signaling pathway (GO:0050855)2.34795790
73negative regulation of cell killing (GO:0031342)2.34175319
74negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.34175319
75presynaptic membrane assembly (GO:0097105)2.33687903
76regulation of dendritic spine morphogenesis (GO:0061001)2.32561663
77positive regulation of mast cell activation (GO:0033005)2.32109056
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.31490291
79L-phenylalanine metabolic process (GO:0006558)2.31490291
80regulation of mast cell degranulation (GO:0043304)2.31460813
81dendrite morphogenesis (GO:0048813)2.30709172
82glucocorticoid biosynthetic process (GO:0006704)2.30308637
83long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.29935592
84detection of other organism (GO:0098543)2.29603686
85positive regulation of chemokine secretion (GO:0090197)2.28354076
86creatine metabolic process (GO:0006600)2.28130534
87detection of temperature stimulus involved in sensory perception (GO:0050961)2.27960837
88detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.27960837
89hydrogen peroxide biosynthetic process (GO:0050665)2.27671010
90antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.26457128
91nerve growth factor signaling pathway (GO:0038180)2.26160132
92very long-chain fatty acid metabolic process (GO:0000038)2.25090987
93regulation of glutamate receptor signaling pathway (GO:1900449)2.24642192
94regulation of dendritic spine development (GO:0060998)2.24054026
95peptidyl-tyrosine autophosphorylation (GO:0038083)2.22535110
96sterol biosynthetic process (GO:0016126)2.22307718
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.20871839
98response to muramyl dipeptide (GO:0032495)2.20820749
99regulation of mast cell activation involved in immune response (GO:0033006)2.20545500
100cellular response to antibiotic (GO:0071236)2.20043061
101fatty-acyl-CoA biosynthetic process (GO:0046949)2.19831227
102regulation of mast cell activation (GO:0033003)2.19615266
103layer formation in cerebral cortex (GO:0021819)2.19611539
104antigen processing and presentation of endogenous antigen (GO:0019883)2.19386272
105negative regulation of cAMP-mediated signaling (GO:0043951)2.19165737
106positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.19041087
107plasma lipoprotein particle clearance (GO:0034381)2.18563478
108fatty-acyl-CoA metabolic process (GO:0035337)2.18322037
109cell migration involved in heart development (GO:0060973)2.18269525
110response to nerve growth factor (GO:1990089)2.17234562
111cellular response to nerve growth factor stimulus (GO:1990090)2.17234562
112neuronal action potential propagation (GO:0019227)2.16980810
113long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.16918869
114transmission of nerve impulse (GO:0019226)2.16403570
115cardiac ventricle formation (GO:0003211)2.16324495
116mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.15538300
117regulation of lipoprotein metabolic process (GO:0050746)2.15479518
118aromatic amino acid family catabolic process (GO:0009074)2.14487957
119positive regulation of extracellular matrix organization (GO:1903055)2.14103814
120cellular response to cadmium ion (GO:0071276)2.13704306
121negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.13093140
122insulin-like growth factor receptor signaling pathway (GO:0048009)2.12991661
123regulation of leukocyte degranulation (GO:0043300)2.12238535
124ATP synthesis coupled proton transport (GO:0015986)2.11672317
125energy coupled proton transport, down electrochemical gradient (GO:0015985)2.11672317
126Rap protein signal transduction (GO:0032486)2.11648224
127macrophage activation (GO:0042116)2.11436912
128positive regulation of mast cell degranulation (GO:0043306)2.11276112
129positive regulation of mast cell activation involved in immune response (GO:0033008)2.11276112
130substantia nigra development (GO:0021762)2.10807883
131glucocorticoid metabolic process (GO:0008211)2.10556127
132positive regulation of oligodendrocyte differentiation (GO:0048714)2.10270229
133regulation of cholesterol storage (GO:0010885)2.09995929
134regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.09990469
135granulocyte activation (GO:0036230)2.09887709
136synaptic vesicle exocytosis (GO:0016079)2.09765757
137regulation of fibrinolysis (GO:0051917)2.09493668
138myelin maintenance (GO:0043217)2.09365661
139mating behavior (GO:0007617)2.08508993
140regulation of Rap GTPase activity (GO:0032317)2.07915163
141detection of bacterium (GO:0016045)2.07628376
142opsonization (GO:0008228)2.07505428
143positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.07435744
144ketone body metabolic process (GO:1902224)2.07405832
145B cell receptor signaling pathway (GO:0050853)2.07334350
146cerebral cortex radially oriented cell migration (GO:0021799)2.06823024
147cellular response to toxic substance (GO:0097237)2.06518972
148sialylation (GO:0097503)2.06500681
149C21-steroid hormone biosynthetic process (GO:0006700)2.06313858
150mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.06300555
151regulation of filopodium assembly (GO:0051489)2.06046985
152positive regulation of interleukin-17 production (GO:0032740)2.05978796
153negative regulation of microtubule polymerization (GO:0031115)2.05539158
154neutrophil activation (GO:0042119)2.05388443
155exploration behavior (GO:0035640)2.05333794
156regulation of excitatory postsynaptic membrane potential (GO:0060079)2.05321210
157positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.05078329
158establishment of endothelial barrier (GO:0061028)2.05040149
159positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.04982110
160myeloid dendritic cell differentiation (GO:0043011)2.04684593
161glyoxylate metabolic process (GO:0046487)2.04180042
162cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.03476054
163positive regulation of dendritic spine development (GO:0060999)2.03354652
164positive regulation of synapse assembly (GO:0051965)2.03079983
165negative regulation of axon extension (GO:0030517)2.02902487
166regulation of regulated secretory pathway (GO:1903305)2.02382693
167membrane tubulation (GO:0097320)2.02212354
168neutrophil chemotaxis (GO:0030593)2.01939206
169negative regulation of axonogenesis (GO:0050771)2.00979012
170coenzyme catabolic process (GO:0009109)2.00902300
171cAMP biosynthetic process (GO:0006171)2.00825699
172cofactor catabolic process (GO:0051187)2.00781900
173detection of biotic stimulus (GO:0009595)2.00552588
174acetyl-CoA metabolic process (GO:0006084)2.00078673
175negative regulation of production of molecular mediator of immune response (GO:0002701)1.99776195
176negative regulation of amyloid precursor protein catabolic process (GO:1902992)1.99601948
177heme transport (GO:0015886)1.99475981
178regulation of gamma-delta T cell differentiation (GO:0045586)1.99245843
179iron coordination entity transport (GO:1901678)1.99151425
180negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.98470232
181negative regulation of granulocyte differentiation (GO:0030853)1.97543422
182glycosphingolipid biosynthetic process (GO:0006688)1.97468766
183antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.97310050
184toxin metabolic process (GO:0009404)1.97194562
185positive regulation of filopodium assembly (GO:0051491)1.97140198
186thioester biosynthetic process (GO:0035384)1.96596542
187acyl-CoA biosynthetic process (GO:0071616)1.96596542
188neuron-neuron synaptic transmission (GO:0007270)1.96547076
189neutrophil migration (GO:1990266)1.96452009
190activation of protein kinase A activity (GO:0034199)1.96422161
191regulation of myeloid leukocyte mediated immunity (GO:0002886)1.96327229
192positive regulation of heat generation (GO:0031652)1.94971419
193behavioral response to cocaine (GO:0048148)1.94352392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63696312
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.95672443
3GBX2_23144817_ChIP-Seq_PC3_Human2.86725823
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67629176
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53254454
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50782312
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.48550512
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25157407
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.19961536
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19512302
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18389805
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16240571
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16240571
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.13202386
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11637080
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05739213
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.04373052
18TAF15_26573619_Chip-Seq_HEK293_Human2.02151969
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.00642266
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00531131
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93645796
22* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91798890
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89206825
24AR_21572438_ChIP-Seq_LNCaP_Human1.87945212
25* EZH2_27294783_Chip-Seq_ESCs_Mouse1.85783690
26* RUNX_20019798_ChIP-Seq_JUKART_Human1.85251720
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84878727
28* IRF8_27001747_Chip-Seq_BMDM_Mouse1.80798833
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.79507366
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.68675032
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67877439
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65383647
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61146946
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.57605445
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57604958
36SCL_19346495_ChIP-Seq_HPC-7_Human1.57162434
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55189831
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52200556
39DROSHA_22980978_ChIP-Seq_HELA_Human1.51712383
40KDM2B_26808549_Chip-Seq_DND41_Human1.50602845
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49238795
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48008976
43KDM2B_26808549_Chip-Seq_K562_Human1.47747973
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.47114864
45P300_19829295_ChIP-Seq_ESCs_Human1.46991824
46* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46491791
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46431285
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46381945
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46169660
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45560362
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.45011378
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.44986837
53* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44595235
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44425324
55* SPI1_23127762_ChIP-Seq_K562_Human1.43940406
56REST_21632747_ChIP-Seq_MESCs_Mouse1.43907507
57* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43741543
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42194089
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41510848
60VDR_22108803_ChIP-Seq_LS180_Human1.39396579
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36566117
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36556115
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33280171
64* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30208622
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29673545
66* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29508573
67* SMAD3_21741376_ChIP-Seq_EPCs_Human1.28706025
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27561139
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26709809
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26201905
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25174208
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23872163
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.23799367
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23241789
75TCF7_22412390_ChIP-Seq_EML_Mouse1.22950781
76* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21679394
77* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21055762
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20787767
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18882349
80ER_23166858_ChIP-Seq_MCF-7_Human1.17235657
81SMAD4_21799915_ChIP-Seq_A2780_Human1.16339084
82* KDM2B_26808549_Chip-Seq_JURKAT_Human1.15972129
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13838309
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13420592
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12945880
86* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12355445
87* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12355445
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11892266
89TP53_18474530_ChIP-ChIP_U2OS_Human1.11191103
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.11141784
91* PRDM14_20953172_ChIP-Seq_ESCs_Human1.10862597
92AHR_22903824_ChIP-Seq_MCF-7_Human1.10111702
93* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10000169
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09697517
95VDR_24763502_ChIP-Seq_THP-1_Human1.09548414
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.08692807
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08384090
98LXR_22292898_ChIP-Seq_THP-1_Human1.08285663
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06950546
100TP53_16413492_ChIP-PET_HCT116_Human1.05863566
101REST_18959480_ChIP-ChIP_MESCs_Mouse1.05746367
102* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05440382
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05372041
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.05184697
105* EP300_21415370_ChIP-Seq_HL-1_Mouse1.05110855
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03772406
107* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03645322
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02971240
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02945521
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02731576
111RARB_27405468_Chip-Seq_BRAIN_Mouse1.02182835
112* GATA1_19941826_ChIP-Seq_K562_Human1.02044606
113AR_25329375_ChIP-Seq_VCAP_Human1.01426158
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01182393
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01038480
116* LXR_22158963_ChIP-Seq_LIVER_Mouse1.00830328
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99796134
118ZNF274_21170338_ChIP-Seq_K562_Hela0.98649659
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97578577
120* SOX2_21211035_ChIP-Seq_LN229_Gbm0.97524300
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97178854
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.96860206
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96754984
124* RXR_22158963_ChIP-Seq_LIVER_Mouse0.96387869
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96234937
126BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96042681
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.95887060
128PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95504226
129KDM2B_26808549_Chip-Seq_REH_Human0.94568183
130RUNX1_22412390_ChIP-Seq_EML_Mouse0.92881032
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92105575
132* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91138989
133* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89958420
134* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89916989
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89460607
136* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88684592
137RING1B_27294783_Chip-Seq_NPCs_Mouse0.88415863
138ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88054597
139NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87901525
140EGR1_19032775_ChIP-ChIP_M12_Human0.87636087
141RUNX2_22187159_ChIP-Seq_PCA_Human0.87399943
142ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87199735
143BCAT_22108803_ChIP-Seq_LS180_Human0.87125385
144POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86293234
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86293234
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.85433346
147ESR1_20079471_ChIP-ChIP_T-47D_Human0.85222243
148GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84948315
149* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84690738
150VDR_24787735_ChIP-Seq_THP-1_Human0.84184498
151* SMAD4_21741376_ChIP-Seq_EPCs_Human0.83545379
152BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83193334
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82737377
154* STAT3_23295773_ChIP-Seq_U87_Human0.82537366
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.81692849
156P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80727813
157FUS_26573619_Chip-Seq_HEK293_Human0.80503460
158* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80389463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.58147016
2MP0004859_abnormal_synaptic_plasticity3.23998140
3MP0000920_abnormal_myelination2.71905519
4MP0003436_decreased_susceptibility_to2.54928961
5MP0003329_amyloid_beta_deposits2.50121438
6MP0003635_abnormal_synaptic_transmissio2.49026286
7MP0004270_analgesia2.48313347
8MP0002063_abnormal_learning/memory/cond2.17550126
9MP0000465_gastrointestinal_hemorrhage2.14261300
10MP0004510_myositis2.14239565
11MP0009745_abnormal_behavioral_response2.10899984
12MP0002064_seizures2.07295301
13MP0005423_abnormal_somatic_nervous2.05587795
14MP0005360_urolithiasis2.03229102
15MP0000604_amyloidosis2.02874247
16MP0005671_abnormal_response_to1.98910665
17MP0000778_abnormal_nervous_system1.98320013
18MP0001486_abnormal_startle_reflex1.96376460
19MP0008004_abnormal_stomach_pH1.93371132
20MP0003690_abnormal_glial_cell1.92044688
21MP0002272_abnormal_nervous_system1.90860330
22MP0000343_altered_response_to1.90702438
23MP0001440_abnormal_grooming_behavior1.90293224
24MP0002572_abnormal_emotion/affect_behav1.88437058
25MP0001800_abnormal_humoral_immune1.86499077
26MP0001501_abnormal_sleep_pattern1.85907872
27MP0002139_abnormal_hepatobiliary_system1.84941670
28MP0003828_pulmonary_edema1.84541384
29MP0009785_altered_susceptibility_to1.84189083
30MP0005025_abnormal_response_to1.80872774
31MP0009840_abnormal_foam_cell1.79171220
32MP0002998_abnormal_bone_remodeling1.77622869
33MP0003300_gastrointestinal_ulcer1.72546140
34MP0002837_dystrophic_cardiac_calcinosis1.70036433
35MP0001968_abnormal_touch/_nociception1.68183955
36MP0002452_abnormal_antigen_presenting1.66296713
37MP0002723_abnormal_immune_serum1.65546903
38MP0004742_abnormal_vestibular_system1.65512999
39MP0002736_abnormal_nociception_after1.64722045
40MP0001905_abnormal_dopamine_level1.63399501
41MP0003303_peritoneal_inflammation1.63111344
42MP0003195_calcinosis1.61630078
43MP0002420_abnormal_adaptive_immunity1.57862210
44MP0006276_abnormal_autonomic_nervous1.56563864
45MP0001533_abnormal_skeleton_physiology1.54233673
46MP0001819_abnormal_immune_cell1.53814637
47MP0008875_abnormal_xenobiotic_pharmacok1.53442843
48MP0001529_abnormal_vocalization1.52645309
49MP0002735_abnormal_chemical_nociception1.46762823
50MP0003172_abnormal_lysosome_physiology1.45783558
51MP0000751_myopathy1.45145956
52MP0009379_abnormal_foot_pigmentation1.43502942
53MP0004947_skin_inflammation1.43282432
54MP0005058_abnormal_lysosome_morphology1.43107730
55MP0001873_stomach_inflammation1.40852248
56MP0001879_abnormal_lymphatic_vessel1.40580184
57MP0002405_respiratory_system_inflammati1.39820062
58MP0003724_increased_susceptibility_to1.39742849
59MP0005409_darkened_coat_color1.37282979
60MP0005083_abnormal_biliary_tract1.34491800
61MP0010368_abnormal_lymphatic_system1.33185446
62MP0009046_muscle_twitch1.32895211
63MP0002734_abnormal_mechanical_nocicepti1.31880545
64MP0005085_abnormal_gallbladder_physiolo1.31745137
65MP0002067_abnormal_sensory_capabilities1.31227097
66MP0003191_abnormal_cellular_cholesterol1.21689762
67MP0003633_abnormal_nervous_system1.21523281
68MP0000685_abnormal_immune_system1.21173797
69MP0003634_abnormal_glial_cell1.20642964
70MP0009278_abnormal_bone_marrow1.20084459
71MP0003091_abnormal_cell_migration1.18613406
72MP0003879_abnormal_hair_cell1.16902008
73MP0002184_abnormal_innervation1.15883709
74MP0005535_abnormal_body_temperature1.14724386
75MP0001845_abnormal_inflammatory_respons1.14175100
76MP0003075_altered_response_to1.14094722
77MP0003631_nervous_system_phenotype1.13642165
78MP0002733_abnormal_thermal_nociception1.13147975
79MP0005666_abnormal_adipose_tissue1.12091152
80MP0005167_abnormal_blood-brain_barrier1.10975622
81MP0006082_CNS_inflammation1.08280788
82MP0001970_abnormal_pain_threshold1.08018693
83MP0004885_abnormal_endolymph1.07563965
84MP0002933_joint_inflammation1.07034442
85MP0003763_abnormal_thymus_physiology1.06873950
86MP0005386_behavior/neurological_phenoty1.06510165
87MP0004924_abnormal_behavior1.06510165
88MP0005365_abnormal_bile_salt1.06407127
89MP0004381_abnormal_hair_follicle1.05768679
90MP0005164_abnormal_response_to1.04229996
91MP0004883_abnormal_blood_vessel1.01975376
92MP0000249_abnormal_blood_vessel1.01860439
93MP0004142_abnormal_muscle_tone1.01224125
94MP0005334_abnormal_fat_pad1.01183673
95MP0002066_abnormal_motor_capabilities/c1.01049388
96MP0008874_decreased_physiological_sensi1.00234429
97MP0000716_abnormal_immune_system1.00182948
98MP0004484_altered_response_of0.99656718
99MP0009115_abnormal_fat_cell0.99489878
100MP0010155_abnormal_intestine_physiology0.98045146
101MP0002909_abnormal_adrenal_gland0.98029504
102MP0005464_abnormal_platelet_physiology0.97489860
103MP0000569_abnormal_digit_pigmentation0.97476441
104MP0004036_abnormal_muscle_relaxation0.96921489
105MP0001790_abnormal_immune_system0.96659339
106MP0005387_immune_system_phenotype0.96659339
107MP0001851_eye_inflammation0.95951549
108MP0003632_abnormal_nervous_system0.95382736
109MP0005375_adipose_tissue_phenotype0.94557546
110MP0008569_lethality_at_weaning0.94529350
111MP0005310_abnormal_salivary_gland0.94221552
112MP0004130_abnormal_muscle_cell0.92749707
113MP0005584_abnormal_enzyme/coenzyme_acti0.92510085
114MP0010329_abnormal_lipoprotein_level0.91610360
115MP0002295_abnormal_pulmonary_circulatio0.90392605
116MP0005451_abnormal_body_composition0.88760395
117MP0002557_abnormal_social/conspecific_i0.88181503
118MP0002882_abnormal_neuron_morphology0.86702125
119MP0005595_abnormal_vascular_smooth0.84422009
120MP0001849_ear_inflammation0.83576260
121MP0005332_abnormal_amino_acid0.82126450
122MP0000955_abnormal_spinal_cord0.81943622
123MP0002118_abnormal_lipid_homeostasis0.81762646
124MP0000767_abnormal_smooth_muscle0.81615488
125MP0002229_neurodegeneration0.81114299
126MP0003279_aneurysm0.78787124
127MP0008469_abnormal_protein_level0.78659139
128MP0002398_abnormal_bone_marrow0.78330723
129MP0005645_abnormal_hypothalamus_physiol0.75367918
130MP0004085_abnormal_heartbeat0.75299128
131MP0001663_abnormal_digestive_system0.75201082
132MP0004858_abnormal_nervous_system0.74887413
133MP0001958_emphysema0.74155198
134MP0004811_abnormal_neuron_physiology0.72970937
135MP0002332_abnormal_exercise_endurance0.72725583
136MP0004782_abnormal_surfactant_physiolog0.72395253
137MP0005000_abnormal_immune_tolerance0.72195658
138MP0005388_respiratory_system_phenotype0.72148223
139MP0002133_abnormal_respiratory_system0.72148223
140MP0005166_decreased_susceptibility_to0.71750458
141MP0001502_abnormal_circadian_rhythm0.71413800
142MP0002138_abnormal_hepatobiliary_system0.70719374
143MP0002254_reproductive_system_inflammat0.70009748
144MP0002419_abnormal_innate_immunity0.68800649
145MP0002148_abnormal_hypersensitivity_rea0.66703426
146MP0000230_abnormal_systemic_arterial0.63835643
147MP0005410_abnormal_fertilization0.63317039
148MP0004145_abnormal_muscle_electrophysio0.62519561
149MP0009764_decreased_sensitivity_to0.61514244
150MP0001963_abnormal_hearing_physiology0.61357283
151MP0005551_abnormal_eye_electrophysiolog0.60592185
152MP0001835_abnormal_antigen_presentation0.60345043

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.73668156
2Cerebral inclusion bodies (HP:0100314)5.26653206
3Autoimmune thrombocytopenia (HP:0001973)5.03252996
4Eczematoid dermatitis (HP:0000976)4.29726546
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.09251024
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.09251024
7Supranuclear gaze palsy (HP:0000605)3.76608824
8Abnormality of the corticospinal tract (HP:0002492)3.65110967
9Insidious onset (HP:0003587)3.57842430
10Termporal pattern (HP:0011008)3.57842430
11Cerebral hemorrhage (HP:0001342)3.56323569
12Abnormality of macrophages (HP:0004311)3.55079978
13Abnormality of liposaccharide metabolism (HP:0010968)3.54177484
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.54177484
15Abnormality of glycolipid metabolism (HP:0010969)3.54177484
16Increased IgM level (HP:0003496)3.32681038
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.31962878
18Focal motor seizures (HP:0011153)3.22408989
19Deep venous thrombosis (HP:0002625)3.18914092
20Hyperventilation (HP:0002883)3.15140833
21Parakeratosis (HP:0001036)3.07748395
22Recurrent abscess formation (HP:0002722)2.97066647
23Autoimmune hemolytic anemia (HP:0001890)2.97041077
24Hyperlipoproteinemia (HP:0010980)2.86473847
25Myokymia (HP:0002411)2.83414233
26Retrobulbar optic neuritis (HP:0100654)2.79202450
27Optic neuritis (HP:0100653)2.79202450
28Abnormality of T cell number (HP:0011839)2.78972196
29Axonal loss (HP:0003447)2.75283842
30Orchitis (HP:0100796)2.74407049
31Prolonged partial thromboplastin time (HP:0003645)2.73056095
32Cellulitis (HP:0100658)2.72805768
33Dysmetria (HP:0001310)2.71785468
34Action tremor (HP:0002345)2.68109334
35Myositis (HP:0100614)2.67711686
36Focal seizures (HP:0007359)2.66823798
37Abnormality of glycolysis (HP:0004366)2.66375551
38Increased serum pyruvate (HP:0003542)2.66375551
39Neonatal hypoglycemia (HP:0001998)2.65558579
40Mediastinal lymphadenopathy (HP:0100721)2.59684554
41Onion bulb formation (HP:0003383)2.58120905
42Vasculitis (HP:0002633)2.55909258
43Abnormality of the fingertips (HP:0001211)2.53628710
44Obstructive sleep apnea (HP:0002870)2.51191755
45Papilledema (HP:0001085)2.51005226
46Amyloidosis (HP:0011034)2.50805614
47Dysostosis multiplex (HP:0000943)2.46020718
48Eosinophilia (HP:0001880)2.37895834
49Hemiparesis (HP:0001269)2.36923328
50Acute necrotizing encephalopathy (HP:0006965)2.36239702
51Spastic gait (HP:0002064)2.33712313
52Amblyopia (HP:0000646)2.32236626
53Retinal dysplasia (HP:0007973)2.31433709
54Peripheral hypomyelination (HP:0007182)2.31367260
55Meningitis (HP:0001287)2.31255108
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.31108408
57Diminished motivation (HP:0000745)2.29212848
58Hypophosphatemic rickets (HP:0004912)2.28503091
59Loss of speech (HP:0002371)2.26079178
60Ankle clonus (HP:0011448)2.25324167
61Ulnar claw (HP:0001178)2.25218845
62Xanthomatosis (HP:0000991)2.24764609
63Disinhibition (HP:0000734)2.22258021
64Acute encephalopathy (HP:0006846)2.21231517
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.20702051
66Abnormality of the columella (HP:0009929)2.20269251
67Abnormal mitochondria in muscle tissue (HP:0008316)2.18788661
68Enlarged epiphyses (HP:0010580)2.18373159
69Clumsiness (HP:0002312)2.18219614
70Scanning speech (HP:0002168)2.18096316
71Hypochromic anemia (HP:0001931)2.17530626
72Segmental peripheral demyelination/remyelination (HP:0003481)2.17415343
73Recurrent gram-negative bacterial infections (HP:0005420)2.16815483
74Drooling (HP:0002307)2.16017337
75Excessive salivation (HP:0003781)2.16017337
76Urticaria (HP:0001025)2.13741517
77Hemiplegia (HP:0002301)2.13590649
78Increased circulating renin level (HP:0000848)2.13068316
79Intention tremor (HP:0002080)2.12903106
80Broad-based gait (HP:0002136)2.11810720
81Increased cerebral lipofuscin (HP:0011813)2.11025268
82Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.11005174
83Urinary urgency (HP:0000012)2.10827964
84Dialeptic seizures (HP:0011146)2.09689820
85Progressive cerebellar ataxia (HP:0002073)2.09434436
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08501590
87Abnormality of polysaccharide metabolism (HP:0011012)2.08501590
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08501590
89Osteomyelitis (HP:0002754)2.08145890
90Muscle hypertrophy of the lower extremities (HP:0008968)2.07732832
91Keratoconjunctivitis sicca (HP:0001097)2.07468299
92Progressive macrocephaly (HP:0004481)2.07449750
93Leukodystrophy (HP:0002415)2.06336562
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06092185
95Absence seizures (HP:0002121)2.05872725
96Conjunctival telangiectasia (HP:0000524)2.05836986
97Generalized tonic-clonic seizures (HP:0002069)2.05700028
98Leukocytosis (HP:0001974)2.03967249
99Hematochezia (HP:0002573)2.03762713
100Atonic seizures (HP:0010819)2.02940130
101Abnormality of the right ventricle (HP:0001707)2.02845026
102Urinary glycosaminoglycan excretion (HP:0003541)2.02543104
103Mucopolysacchariduria (HP:0008155)2.02543104
104Joint hemorrhage (HP:0005261)2.02519242
105Cerebral edema (HP:0002181)2.02411834
106Psychosis (HP:0000709)1.99939258
107Chronic obstructive pulmonary disease (HP:0006510)1.99485548
108Obstructive lung disease (HP:0006536)1.99485548
109Truncal ataxia (HP:0002078)1.99389635
110Buphthalmos (HP:0000557)1.99230391
111Gastrointestinal stroma tumor (HP:0100723)1.98968846
112Granulocytopenia (HP:0001913)1.98674448
113Growth hormone excess (HP:0000845)1.97634645
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97528045
115Complement deficiency (HP:0004431)1.97192248
116Epileptic encephalopathy (HP:0200134)1.96985253
117Interstitial pulmonary disease (HP:0006530)1.96593025
118Polycythemia (HP:0001901)1.96158921
119Verrucae (HP:0200043)1.96108072
120Papilloma (HP:0012740)1.96108072
121Hypercortisolism (HP:0001578)1.93914886
122Thickened helices (HP:0000391)1.92983491
123Hemoptysis (HP:0002105)1.92457762
124Diplopia (HP:0000651)1.92053517
125Abnormality of binocular vision (HP:0011514)1.92053517
126Pulmonary embolism (HP:0002204)1.90310741
127Slow saccadic eye movements (HP:0000514)1.90245274
128Rapidly progressive (HP:0003678)1.89872274
129Dysdiadochokinesis (HP:0002075)1.89810908
130Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.89300514
131Morphological abnormality of the pyramidal tract (HP:0002062)1.88993576
132Mutism (HP:0002300)1.88849728
133Spontaneous hematomas (HP:0007420)1.88750391
134Prolonged bleeding time (HP:0003010)1.88690605
135Progressive inability to walk (HP:0002505)1.88652180
136Ventricular fibrillation (HP:0001663)1.87903398
137Absent frontal sinuses (HP:0002688)1.87581518
138Gingivitis (HP:0000230)1.87363486
139Keratoconjunctivitis (HP:0001096)1.87256779
140Anxiety (HP:0000739)1.86584264
141Peripheral demyelination (HP:0011096)1.86383848
142Visual hallucinations (HP:0002367)1.84747897
143Abnormal eating behavior (HP:0100738)1.84634072
144Postural tremor (HP:0002174)1.84463025
145Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84001209
146Recurrent fungal infections (HP:0002841)1.82740283
147Sensory axonal neuropathy (HP:0003390)1.82124314
148Abnormality of salivation (HP:0100755)1.80577098
149Lower limb muscle weakness (HP:0007340)1.80447065
150Hypergammaglobulinemia (HP:0010702)1.79757582
151Neuronal loss in central nervous system (HP:0002529)1.79364960
152Abnormality of eosinophils (HP:0001879)1.78772889
153Abnormality of cells of the lymphoid lineage (HP:0012140)1.77327150
154Stomatitis (HP:0010280)1.75526580
155Abnormality of the frontal sinuses (HP:0002687)1.75316340
156Renal Fanconi syndrome (HP:0001994)1.75166670
157Cerebral aneurysm (HP:0004944)1.74910997
158Restrictive lung disease (HP:0002091)1.74890396
159Memory impairment (HP:0002354)1.74556796
160Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74041256
161Systemic lupus erythematosus (HP:0002725)1.73492429
162Apathy (HP:0000741)1.72269554
163Poor eye contact (HP:0000817)1.70732860
164Agammaglobulinemia (HP:0004432)1.70467588
165Intrahepatic cholestasis (HP:0001406)1.68888541
166Hypobetalipoproteinemia (HP:0003563)1.68873521
167Recurrent bacterial skin infections (HP:0005406)1.68595561
168Polyphagia (HP:0002591)1.67145032
169Global brain atrophy (HP:0002283)1.67095908
170Exotropia (HP:0000577)1.66960961
171Spontaneous abortion (HP:0005268)1.65260706
172Stridor (HP:0010307)1.65203862
173Hypoplasia of the iris (HP:0007676)1.64589439
174Blue irides (HP:0000635)1.62550587
175Mitochondrial inheritance (HP:0001427)1.62403384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.31683573
2MARK13.14352284
3EPHB12.83896015
4STK392.71821180
5EPHA42.46415066
6FGR2.32200267
7TLK12.24784553
8PIK3CA2.20238535
9SIK22.16366475
10PNCK2.10406503
11TAOK12.08562565
12PKN12.05081030
13MAP3K41.95534986
14OXSR11.91209377
15PRPF4B1.74659068
16NTRK31.70585930
17GRK71.65488828
18TIE11.65019345
19FES1.63224304
20PTK2B1.62795817
21MAP2K31.61582707
22ZAP701.56837367
23DAPK21.54100652
24MAP2K41.52295096
25MAPK131.52223884
26MAP2K71.52190862
27KDR1.49613773
28IRAK31.48247504
29MARK31.46379744
30NTRK21.45914700
31TRIB31.44030688
32BCR1.34179225
33CAMK1G1.32808152
34FGFR21.32474221
35UHMK11.30504384
36GRK51.26609150
37DYRK21.26296581
38CASK1.25572810
39WNK41.23674435
40CAMK2B1.22569628
41GRK61.20918224
42MAP3K91.18278195
43PAK61.17772857
44BMPR21.17549007
45CAMKK11.14589549
46CAMKK21.13160452
47MINK11.11255101
48BLK1.10528626
49CAMK2A1.07286298
50MAP3K31.07250226
51* MAPK121.06406241
52SIK11.06117153
53PDGFRB1.04870297
54MOS1.04810055
55JAK11.02016090
56TYK21.01082866
57MAP3K121.00282877
58CDK51.00003906
59TXK0.99929095
60PLK20.99557631
61JAK20.98780163
62PINK10.97125319
63CDC42BPA0.95461422
64SYK0.94930459
65CAMK1D0.94918699
66PRKCQ0.94282053
67MAP3K130.94223597
68CSNK1G20.94203785
69CSNK1A1L0.93472106
70CSNK1G30.92962896
71LATS20.92137046
72MAPKAPK50.91998535
73NME10.90474310
74SGK20.90423555
75MAP3K10.90363867
76KSR20.88790722
77TGFBR20.88119763
78TAOK30.87287579
79MARK20.86874175
80SGK30.86872832
81PHKG10.86787480
82PHKG20.86787480
83BTK0.85454509
84RIPK10.85436728
85NTRK10.84271370
86MAP3K140.81877459
87PBK0.81303036
88ROCK20.80261836
89IRAK40.80248946
90TNIK0.78833552
91ERN10.78397969
92IKBKE0.77503092
93KIT0.77221917
94DDR20.76814117
95ADRBK20.76393396
96PAK30.74865298
97INSRR0.74426313
98MAPK40.74281760
99LATS10.71901906
100MAP2K60.71899153
101JAK30.71724491
102DYRK1A0.71684487
103PRKCE0.71243429
104KSR10.70317634
105TYRO30.69747274
106LCK0.69499710
107FYN0.68701871
108MAP3K110.65881149
109CAMK40.64540466
110STK110.64486777
111LYN0.64287371
112SGK2230.64118339
113SGK4940.64118339
114CAMK10.63805144
115CAMK2D0.63748122
116STK100.63746038
117CSNK1G10.61795340
118PDPK10.61070021
119TAOK20.61056709
120FGFR30.59043404
121STK380.58766796
122CSK0.58345635
123PRKD10.57763721
124MATK0.57633205
125CLK10.57285539
126PRKCZ0.57074597
127DMPK0.56902054
128AKT30.55293495
129ICK0.55049146
130NEK60.54501880
131BMPR1B0.53628633
132TNK20.53472977
133MAPK70.53214778
134CSF1R0.52376846
135WNK30.51952888
136IKBKB0.51680440
137ABL20.51542868
138MAP3K50.51507030
139EGFR0.51423649
140PDK10.51217678
141PRKCH0.50839357
142PRKCG0.50761096
143HCK0.48554534
144MAP4K10.47765583
145WNK10.47417393
146MAP3K60.46976271
147SIK30.46710926
148MET0.46393776
149TBK10.45786977
150CAMK2G0.45007135
151ADRBK10.44871844
152GSK3A0.43956961
153MST40.43811522
154FGFR40.43079440
155RET0.42301985
156SGK10.41803935

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86788674
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.33282890
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17750398
4Steroid biosynthesis_Homo sapiens_hsa001002.01535795
5Nicotine addiction_Homo sapiens_hsa050331.99401048
6Fatty acid elongation_Homo sapiens_hsa000621.99263473
7Allograft rejection_Homo sapiens_hsa053301.70769300
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68029897
9Glutamatergic synapse_Homo sapiens_hsa047241.67374548
10Nitrogen metabolism_Homo sapiens_hsa009101.65846329
11Autoimmune thyroid disease_Homo sapiens_hsa053201.61738639
12Oxidative phosphorylation_Homo sapiens_hsa001901.57090528
13Leishmaniasis_Homo sapiens_hsa051401.54927138
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.54556414
15Butanoate metabolism_Homo sapiens_hsa006501.54168055
16Alzheimers disease_Homo sapiens_hsa050101.51002849
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48034324
18Staphylococcus aureus infection_Homo sapiens_hsa051501.47735240
19GABAergic synapse_Homo sapiens_hsa047271.45703208
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43441812
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42509295
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42250284
23Renin secretion_Homo sapiens_hsa049241.41979795
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40024740
25African trypanosomiasis_Homo sapiens_hsa051431.39347365
26Axon guidance_Homo sapiens_hsa043601.35373580
27Complement and coagulation cascades_Homo sapiens_hsa046101.32352654
28Circadian entrainment_Homo sapiens_hsa047131.30237570
29Morphine addiction_Homo sapiens_hsa050321.27876596
30Long-term potentiation_Homo sapiens_hsa047201.27739390
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27667858
32Type I diabetes mellitus_Homo sapiens_hsa049401.25262570
33Histidine metabolism_Homo sapiens_hsa003401.25138045
34Salivary secretion_Homo sapiens_hsa049701.23555991
35T cell receptor signaling pathway_Homo sapiens_hsa046601.23029311
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.21703920
37Serotonergic synapse_Homo sapiens_hsa047261.20867203
38TNF signaling pathway_Homo sapiens_hsa046681.17618305
39Arginine biosynthesis_Homo sapiens_hsa002201.15413192
40Toxoplasmosis_Homo sapiens_hsa051451.13726724
41Ovarian steroidogenesis_Homo sapiens_hsa049131.12702888
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12304622
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11768827
44Long-term depression_Homo sapiens_hsa047301.11736729
45Parkinsons disease_Homo sapiens_hsa050121.11676671
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09686889
47Acute myeloid leukemia_Homo sapiens_hsa052211.09445902
48Dopaminergic synapse_Homo sapiens_hsa047281.06365539
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05363737
50Propanoate metabolism_Homo sapiens_hsa006401.04387965
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03592945
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01611675
53Platelet activation_Homo sapiens_hsa046111.01311374
54Lysosome_Homo sapiens_hsa041421.00842574
55Gastric acid secretion_Homo sapiens_hsa049710.99562040
56Cardiac muscle contraction_Homo sapiens_hsa042600.98268875
57Prolactin signaling pathway_Homo sapiens_hsa049170.95055921
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.94678307
59Influenza A_Homo sapiens_hsa051640.93853523
60Collecting duct acid secretion_Homo sapiens_hsa049660.93593754
61Fatty acid metabolism_Homo sapiens_hsa012120.93493538
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.93088995
63Amphetamine addiction_Homo sapiens_hsa050310.92691060
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92010736
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90631587
66Estrogen signaling pathway_Homo sapiens_hsa049150.90116625
67Taste transduction_Homo sapiens_hsa047420.88236112
68B cell receptor signaling pathway_Homo sapiens_hsa046620.88058691
69Asthma_Homo sapiens_hsa053100.86471864
70Cholinergic synapse_Homo sapiens_hsa047250.85593788
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85431118
72Hepatitis B_Homo sapiens_hsa051610.84991614
73mTOR signaling pathway_Homo sapiens_hsa041500.84677619
74PPAR signaling pathway_Homo sapiens_hsa033200.84626948
75FoxO signaling pathway_Homo sapiens_hsa040680.84102253
76Hematopoietic cell lineage_Homo sapiens_hsa046400.83242780
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82517803
78Tryptophan metabolism_Homo sapiens_hsa003800.82475056
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82151271
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.81652933
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.81582884
82Oxytocin signaling pathway_Homo sapiens_hsa049210.81461938
83Amoebiasis_Homo sapiens_hsa051460.80134724
84Ether lipid metabolism_Homo sapiens_hsa005650.79885721
85Measles_Homo sapiens_hsa051620.79368541
86Endometrial cancer_Homo sapiens_hsa052130.79354666
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.79012845
88Rap1 signaling pathway_Homo sapiens_hsa040150.78147794
89Sulfur metabolism_Homo sapiens_hsa009200.77888522
90ErbB signaling pathway_Homo sapiens_hsa040120.77123830
91MAPK signaling pathway_Homo sapiens_hsa040100.76676718
92Calcium signaling pathway_Homo sapiens_hsa040200.76460708
93Cocaine addiction_Homo sapiens_hsa050300.76421425
94Viral myocarditis_Homo sapiens_hsa054160.75849694
95Apoptosis_Homo sapiens_hsa042100.74204734
96Rheumatoid arthritis_Homo sapiens_hsa053230.74036906
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74024131
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73572712
99Prion diseases_Homo sapiens_hsa050200.73069139
100Non-small cell lung cancer_Homo sapiens_hsa052230.72572172
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72153800
102Choline metabolism in cancer_Homo sapiens_hsa052310.69591820
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.69052675
104Other glycan degradation_Homo sapiens_hsa005110.68284973
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68262535
106Hepatitis C_Homo sapiens_hsa051600.68180907
107Bile secretion_Homo sapiens_hsa049760.67849275
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67725693
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66505604
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66302243
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65330419
112Dorso-ventral axis formation_Homo sapiens_hsa043200.64519031
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63531583
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63433566
115Legionellosis_Homo sapiens_hsa051340.63007583
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63005183
117Synaptic vesicle cycle_Homo sapiens_hsa047210.62821849
118Phagosome_Homo sapiens_hsa041450.62733876
119Renal cell carcinoma_Homo sapiens_hsa052110.62197482
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62046447
121GnRH signaling pathway_Homo sapiens_hsa049120.61964836
122Pancreatic cancer_Homo sapiens_hsa052120.61863057
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61798194
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61731457
125Chemical carcinogenesis_Homo sapiens_hsa052040.61210498
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60284607
127Fatty acid degradation_Homo sapiens_hsa000710.59646068
128Peroxisome_Homo sapiens_hsa041460.59036844
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58774609
130VEGF signaling pathway_Homo sapiens_hsa043700.58276276
131Osteoclast differentiation_Homo sapiens_hsa043800.58060139
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.57662834
133Gap junction_Homo sapiens_hsa045400.57065290
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.56459957
135Chemokine signaling pathway_Homo sapiens_hsa040620.55332923
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54488945
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53111152
138Ras signaling pathway_Homo sapiens_hsa040140.52685296
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51848961
140Malaria_Homo sapiens_hsa051440.51256980
141cAMP signaling pathway_Homo sapiens_hsa040240.51093718
142Pertussis_Homo sapiens_hsa051330.49828021
143Phenylalanine metabolism_Homo sapiens_hsa003600.48911491
144Caffeine metabolism_Homo sapiens_hsa002320.48697241
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.48385970
146Salmonella infection_Homo sapiens_hsa051320.48108339
147Pyruvate metabolism_Homo sapiens_hsa006200.46625775
148beta-Alanine metabolism_Homo sapiens_hsa004100.44102685
149Graft-versus-host disease_Homo sapiens_hsa053320.43457590
150Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43260059
151Type II diabetes mellitus_Homo sapiens_hsa049300.42553755
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41987036
153Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40445519
154Tuberculosis_Homo sapiens_hsa051520.40076044
155Huntingtons disease_Homo sapiens_hsa050160.39911474

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