SH3BP5L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration in hindbrain (GO:0021535)4.08963554
2negative regulation of erythrocyte differentiation (GO:0045647)4.01631818
3synaptic vesicle maturation (GO:0016188)3.99671518
4polarized epithelial cell differentiation (GO:0030859)3.93599749
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.88230809
6negative regulation of cell killing (GO:0031342)3.85612772
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.85612772
8sodium ion export (GO:0071436)3.81087061
9plasma membrane repair (GO:0001778)3.78369501
10cytoskeletal anchoring at plasma membrane (GO:0007016)3.74707330
11positive regulation by symbiont of host defense response (GO:0052509)3.74092508
12modulation by symbiont of host defense response (GO:0052031)3.74092508
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.74092508
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.74092508
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.74092508
16modulation by symbiont of host immune response (GO:0052553)3.74092508
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.72664372
18positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.72297797
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.70372349
20locomotory exploration behavior (GO:0035641)3.66001448
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60110940
22negative regulation of cell size (GO:0045792)3.59394828
23layer formation in cerebral cortex (GO:0021819)3.57875518
24cell communication by electrical coupling (GO:0010644)3.55005618
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.52493826
26negative regulation of microtubule polymerization (GO:0031115)3.47931116
27detection of other organism (GO:0098543)3.45231127
28stress fiber assembly (GO:0043149)3.41026967
29antigen processing and presentation of endogenous antigen (GO:0019883)3.34131871
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.31039370
31detection of bacterium (GO:0016045)3.28611103
32cell communication involved in cardiac conduction (GO:0086065)3.26310004
33negative regulation of potassium ion transmembrane transport (GO:1901380)3.22399074
34activation of protein kinase A activity (GO:0034199)3.21214189
35barbed-end actin filament capping (GO:0051016)3.15879857
36negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.15808367
37response to peptidoglycan (GO:0032494)3.15726771
38synaptic vesicle exocytosis (GO:0016079)3.15503665
39macrophage activation involved in immune response (GO:0002281)3.15001912
40regulation of translational termination (GO:0006449)3.09663083
41establishment of apical/basal cell polarity (GO:0035089)3.08389331
42establishment or maintenance of monopolar cell polarity (GO:0061339)3.05936001
43establishment of monopolar cell polarity (GO:0061162)3.05936001
44focal adhesion assembly (GO:0048041)3.05654179
45cell-substrate adherens junction assembly (GO:0007045)3.05654179
46mannose metabolic process (GO:0006013)3.05619581
47regulation of synaptic vesicle exocytosis (GO:2000300)3.04957361
48detection of external biotic stimulus (GO:0098581)3.04292953
49positive regulation of Cdc42 GTPase activity (GO:0043089)3.02908122
50hypotonic response (GO:0006971)2.99164915
51positive regulation of synapse maturation (GO:0090129)2.98768462
52detection of molecule of bacterial origin (GO:0032490)2.98705331
53positive regulation of receptor recycling (GO:0001921)2.97991558
54glutamate secretion (GO:0014047)2.97689298
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95296067
56positive regulation of gamma-delta T cell activation (GO:0046645)2.94983715
57adherens junction assembly (GO:0034333)2.93937083
58neuromuscular process controlling balance (GO:0050885)2.93928606
59detection of temperature stimulus involved in sensory perception (GO:0050961)2.89517542
60detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.89517542
61regulation of leukocyte degranulation (GO:0043300)2.88652591
62cell-substrate junction assembly (GO:0007044)2.88631074
63response to laminar fluid shear stress (GO:0034616)2.88017545
64Golgi transport vesicle coating (GO:0048200)2.87482081
65COPI coating of Golgi vesicle (GO:0048205)2.87482081
66vocalization behavior (GO:0071625)2.86698558
67cellular potassium ion homeostasis (GO:0030007)2.85856161
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.84426753
69proline transport (GO:0015824)2.83535807
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80863351
71neutrophil activation involved in immune response (GO:0002283)2.80306160
72neuronal action potential propagation (GO:0019227)2.79807901
73retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.79133017
74NADH metabolic process (GO:0006734)2.77468298
75leukocyte aggregation (GO:0070486)2.76305282
76CDP-diacylglycerol metabolic process (GO:0046341)2.73802372
77macroautophagy (GO:0016236)2.71993397
78regulation of T-helper 2 cell differentiation (GO:0045628)2.70632298
79activation of Rac GTPase activity (GO:0032863)2.70174142
80cerebellar Purkinje cell layer development (GO:0021680)2.70116899
81response to muramyl dipeptide (GO:0032495)2.70022686
82dendritic spine morphogenesis (GO:0060997)2.69694913
83axon cargo transport (GO:0008088)2.68484648
84glycine transport (GO:0015816)2.68165286
85tricarboxylic acid cycle (GO:0006099)2.67374520
86positive regulation of sodium ion transport (GO:0010765)2.67343617
873-UTR-mediated mRNA stabilization (GO:0070935)2.67033012
88modulation by symbiont of host cellular process (GO:0044068)2.66284584
89neuromuscular process controlling posture (GO:0050884)2.66104367
90establishment of nucleus localization (GO:0040023)2.65281148
91regulation of synapse structural plasticity (GO:0051823)2.64199972
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.63886343
93apoptotic process involved in morphogenesis (GO:0060561)2.63420123
94regulation of necroptotic process (GO:0060544)2.62609043
95positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.62451884
96signal complex assembly (GO:0007172)2.62398341
97neurotransmitter secretion (GO:0007269)2.61819529
98regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.61240404
99regulation of ARF protein signal transduction (GO:0032012)2.61154105
100regulation of NFAT protein import into nucleus (GO:0051532)2.61067107
101detection of biotic stimulus (GO:0009595)2.60374673
102embryonic process involved in female pregnancy (GO:0060136)2.59869126
103skin morphogenesis (GO:0043589)2.59781645
104pinocytosis (GO:0006907)2.58423122
105cell junction maintenance (GO:0034331)2.58010267
106establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.56803901
107negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.56675101
108synaptic vesicle docking involved in exocytosis (GO:0016081)2.55714559
109exploration behavior (GO:0035640)2.54884201
110cell-cell junction maintenance (GO:0045217)2.53496169
111positive regulation of potassium ion transmembrane transport (GO:1901381)2.53345758
112CDP-diacylglycerol biosynthetic process (GO:0016024)2.53239630
113regulation of interferon-beta biosynthetic process (GO:0045357)2.53122969
114detection of temperature stimulus (GO:0016048)2.52651274
115response to host (GO:0075136)2.52597742
116response to host defenses (GO:0052200)2.52597742
117response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.52597742
118regulation of synaptic vesicle transport (GO:1902803)2.52417056
119regulation of mast cell degranulation (GO:0043304)2.51886039
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.51578845
121regulation of fatty acid beta-oxidation (GO:0031998)2.51385973
122mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.50347064
123regulation of clathrin-mediated endocytosis (GO:2000369)2.50332165
124positive regulation of blood vessel endothelial cell migration (GO:0043536)2.50152303
125positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.48981502
126organelle transport along microtubule (GO:0072384)2.48855743
127protein localization to endosome (GO:0036010)2.48113978
128positive regulation of cellular amide metabolic process (GO:0034250)2.47703797
129regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.47605884
130cellular extravasation (GO:0045123)2.47351007
131regulation of sodium ion transmembrane transporter activity (GO:2000649)2.47170917
132germinal center formation (GO:0002467)2.46196258
133regulation of regulated secretory pathway (GO:1903305)2.45515755
134establishment of mitochondrion localization (GO:0051654)2.45407523
135positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.44760195
136cortical actin cytoskeleton organization (GO:0030866)2.44669108
137neuroblast proliferation (GO:0007405)2.44586262
138positive regulation of sodium ion transmembrane transport (GO:1902307)2.44488340
139potassium ion import (GO:0010107)2.43353382
140vesicle transport along microtubule (GO:0047496)2.42603174
141negative regulation of toll-like receptor signaling pathway (GO:0034122)2.41948408
142mating behavior (GO:0007617)2.41533573
143positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.41436538
144negative regulation of type 2 immune response (GO:0002829)2.41403541
145modulation by virus of host process (GO:0019054)2.41358937
146negative regulation of necroptotic process (GO:0060546)2.40437392
147protein targeting to plasma membrane (GO:0072661)2.39910077
148regulation of macrophage cytokine production (GO:0010935)2.39803243
149response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.39731661
150response to host immune response (GO:0052572)2.39731661
151regulation of ARF GTPase activity (GO:0032312)2.38736350
152positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.38087418
153positive regulation of protein dephosphorylation (GO:0035307)2.37386538
154regulation of extracellular matrix disassembly (GO:0010715)2.37186104
155lipopolysaccharide-mediated signaling pathway (GO:0031663)2.36898838
156response to pheromone (GO:0019236)2.36781430
157alanine transport (GO:0032328)2.36053423
158regulation of early endosome to late endosome transport (GO:2000641)2.36001363
159membrane repolarization (GO:0086009)2.33693983
160negative regulation of leukocyte mediated immunity (GO:0002704)2.32945653
161positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.32628687
162antigen processing and presentation via MHC class Ib (GO:0002475)2.32343107
163basement membrane organization (GO:0071711)2.32287079
164regulation of defense response to virus by virus (GO:0050690)2.32050186
165regulation of glucose import in response to insulin stimulus (GO:2001273)2.31708634
166sarcomere organization (GO:0045214)2.30800478
167regulation of necrotic cell death (GO:0010939)2.29912657
168membrane depolarization during action potential (GO:0086010)2.29561743
169ventricular cardiac muscle cell action potential (GO:0086005)2.28711782
170thioester biosynthetic process (GO:0035384)2.28376133
171acyl-CoA biosynthetic process (GO:0071616)2.28376133
172calcium-mediated signaling using intracellular calcium source (GO:0035584)2.28316569
173regulation of autophagic vacuole assembly (GO:2000785)2.28131358
174positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.27914115
175regulation of glutamate receptor signaling pathway (GO:1900449)2.27147762
176regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.26864170
177ncRNA 3-end processing (GO:0043628)2.26525822
178mitochondrion transport along microtubule (GO:0047497)2.26355808
179establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.26355808
180epithelial cell differentiation involved in prostate gland development (GO:0060742)2.26000267
181leukocyte migration involved in inflammatory response (GO:0002523)2.25366247
182regulation of sodium ion transmembrane transport (GO:1902305)2.25069579
183maternal placenta development (GO:0001893)2.23831663
184negative regulation of myotube differentiation (GO:0010832)2.23167463
185negative regulation of fatty acid transport (GO:2000192)2.23134504
186negative regulation of lymphocyte mediated immunity (GO:0002707)2.22201509
187regulation of type I interferon-mediated signaling pathway (GO:0060338)2.21723375
188regulation of gamma-delta T cell activation (GO:0046643)2.19612298
189cortical cytoskeleton organization (GO:0030865)2.19349600
190activation of JUN kinase activity (GO:0007257)2.18495982
191NIK/NF-kappaB signaling (GO:0038061)2.16357502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human4.30735011
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.96732622
3VDR_21846776_ChIP-Seq_THP-1_Human2.86772119
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.79512986
5ERG_21242973_ChIP-ChIP_JURKAT_Human2.66733652
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.61402060
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.58518452
8ZFP281_18757296_ChIP-ChIP_E14_Mouse2.54113843
9MYC_22102868_ChIP-Seq_BL_Human2.47452675
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40601557
11TCF7_22412390_ChIP-Seq_EML_Mouse2.38307037
12EZH2_22144423_ChIP-Seq_EOC_Human2.34747081
13* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.32357785
14* LXR_22292898_ChIP-Seq_THP-1_Human2.26847278
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.20001822
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.06580561
17KDM2B_26808549_Chip-Seq_K562_Human2.06506969
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00709916
19VDR_24763502_ChIP-Seq_THP-1_Human1.97663479
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.97306990
21* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.91355793
22DNAJC2_21179169_ChIP-ChIP_NT2_Human1.88889828
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84529771
24KDM2B_26808549_Chip-Seq_DND41_Human1.83280489
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81665452
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.81403232
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.76438310
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74508236
29* MAF_26560356_Chip-Seq_TH1_Human1.74482217
30* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73726008
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.73399557
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71805620
33CLOCK_20551151_ChIP-Seq_293T_Human1.70165811
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69515402
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.68676727
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68516768
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66335946
38RACK7_27058665_Chip-Seq_MCF-7_Human1.66133322
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65777644
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.64800962
41CREB1_26743006_Chip-Seq_LNCaP_Human1.62017958
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59069185
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56200205
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56200205
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55382327
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54388962
47* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.52206248
48* ELK3_25401928_ChIP-Seq_HUVEC_Human1.52111279
49UTX_26944678_Chip-Seq_JUKART_Human1.50989768
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50810917
51* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50571459
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50444008
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50028121
54SPI1_23127762_ChIP-Seq_K562_Human1.49926858
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48609050
56* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47962368
57P68_20966046_ChIP-Seq_HELA_Human1.47794182
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46158945
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45355939
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44469979
61* CTCF_27219007_Chip-Seq_Bcells_Human1.43588802
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.43542558
63* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42675437
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42607287
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41784421
66* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40873754
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.39612279
68* REST_21632747_ChIP-Seq_MESCs_Mouse1.39309885
69ATF3_27146783_Chip-Seq_COLON_Human1.38534823
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38426291
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38014924
72* MAF_26560356_Chip-Seq_TH2_Human1.37386513
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37376950
74GATA1_19941826_ChIP-Seq_K562_Human1.36099605
75TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.34356281
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.33922596
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31468523
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31245836
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31112294
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30938116
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.30548182
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30303071
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29867420
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.29109687
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29036513
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28842274
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28346519
88DROSHA_22980978_ChIP-Seq_HELA_Human1.27578761
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27321530
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25875899
91SMC4_20622854_ChIP-Seq_HELA_Human1.25831998
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24974289
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.24710652
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23318946
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23212117
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.22693826
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22564103
98NCOR1_26117541_ChIP-Seq_K562_Human1.21821612
99IRF8_27001747_Chip-Seq_BMDM_Mouse1.21600294
100SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21577278
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21223540
102TP63_22573176_ChIP-Seq_HFKS_Human1.20093181
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18988394
104* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18528356
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18501776
106* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17827059
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.17274248
108ELF1_20517297_ChIP-Seq_JURKAT_Human1.17090736
109IRF8_22096565_ChIP-ChIP_GC-B_Human1.16880005
110OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16577827
111SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14685731
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13639100
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11483699
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11302894
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10739656
116TP53_22127205_ChIP-Seq_IMR90_Human1.10291022
117* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09971856
118YY1_22570637_ChIP-Seq_MALME-3M_Human1.09526022
119FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09081375
120STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08758716
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07426261
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07110170
123EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06613473
124TRIM28_21343339_ChIP-Seq_HEK293_Human1.06116624
125FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04644003
126* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04573162
127* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04480530
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04447017
129SPI1_23547873_ChIP-Seq_NB4_Human1.03939334
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03776083
131STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02408892
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01817151
133KLF4_19829295_ChIP-Seq_ESCs_Human1.01552641
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01389577
135PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00652212
136* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00482632
137KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00286601
138TBX20_22328084_ChIP-Seq_HEART_Mouse1.00112216
139TBX20_22080862_ChIP-Seq_HEART_Mouse1.00112216
140RXR_22158963_ChIP-Seq_LIVER_Mouse1.00038487
141IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99697976
142BCOR_27268052_Chip-Seq_Bcells_Human0.99538998
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99487205
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99108496
145UBF1/2_26484160_Chip-Seq_HMECs_Human0.99006340
146SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98398582
147SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98271291
148KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96456889
149FOXP1_21924763_ChIP-Seq_HESCs_Human0.96218058
150GATA2_21666600_ChIP-Seq_HMVEC_Human0.95474594
151WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94220652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.63042214
2MP0004859_abnormal_synaptic_plasticity3.59700833
3MP0005451_abnormal_body_composition3.17858373
4MP0003436_decreased_susceptibility_to2.95096840
5MP0004270_analgesia2.92504615
6MP0004858_abnormal_nervous_system2.89915234
7MP0003705_abnormal_hypodermis_morpholog2.87068454
8MP0003303_peritoneal_inflammation2.80770030
9MP0003566_abnormal_cell_adhesion2.78015663
10MP0008438_abnormal_cutaneous_collagen2.71550478
11MP0008260_abnormal_autophagy2.71177957
12MP0003191_abnormal_cellular_cholesterol2.68032151
13MP0000751_myopathy2.63701137
14MP0000013_abnormal_adipose_tissue2.50391222
15MP0003300_gastrointestinal_ulcer2.45015584
16MP0008961_abnormal_basal_metabolism2.43777800
17MP0003329_amyloid_beta_deposits2.34370950
18MP0005058_abnormal_lysosome_morphology2.30414745
19MP0003635_abnormal_synaptic_transmissio2.23869969
20MP0003091_abnormal_cell_migration2.16554500
21MP0004130_abnormal_muscle_cell2.08969799
22MP0000747_muscle_weakness2.07089784
23MP0001958_emphysema2.01551436
24MP0002909_abnormal_adrenal_gland1.99846748
25MP0009780_abnormal_chondrocyte_physiolo1.97064663
26MP0004084_abnormal_cardiac_muscle1.94898872
27MP0003724_increased_susceptibility_to1.92840675
28MP0004233_abnormal_muscle_weight1.89318311
29MP0003172_abnormal_lysosome_physiology1.85825049
30MP0005076_abnormal_cell_differentiation1.81793184
31MP0004947_skin_inflammation1.81599891
32MP0009278_abnormal_bone_marrow1.81373919
33MP0005409_darkened_coat_color1.81037707
34MP0003828_pulmonary_edema1.80175750
35MP0002735_abnormal_chemical_nociception1.77818317
36MP0002419_abnormal_innate_immunity1.77036932
37MP0003283_abnormal_digestive_organ1.76204996
38MP0000858_altered_metastatic_potential1.75040025
39MP0002064_seizures1.72971063
40MP0009046_muscle_twitch1.70499163
41MP0004185_abnormal_adipocyte_glucose1.70403040
42MP0003279_aneurysm1.70302474
43MP0002734_abnormal_mechanical_nocicepti1.69913678
44MP0002733_abnormal_thermal_nociception1.66390549
45MP0004885_abnormal_endolymph1.65837192
46MP0002269_muscular_atrophy1.64924742
47MP0002653_abnormal_ependyma_morphology1.61135711
48MP0005464_abnormal_platelet_physiology1.59995273
49MP0003453_abnormal_keratinocyte_physiol1.59586283
50MP0004087_abnormal_muscle_fiber1.58582808
51MP0000003_abnormal_adipose_tissue1.57237941
52MP0002063_abnormal_learning/memory/cond1.56524710
53MP0004147_increased_porphyrin_level1.55205658
54MP0004215_abnormal_myocardial_fiber1.54741197
55MP0004510_myositis1.54190557
56MP0004811_abnormal_neuron_physiology1.52306797
57MP0005025_abnormal_response_to1.52068044
58MP0000685_abnormal_immune_system1.51103400
59MP0001533_abnormal_skeleton_physiology1.50276043
60MP0001968_abnormal_touch/_nociception1.50258429
61MP0000749_muscle_degeneration1.49401034
62MP0003646_muscle_fatigue1.47933396
63MP0005623_abnormal_meninges_morphology1.47764097
64MP0009840_abnormal_foam_cell1.46536049
65MP0004036_abnormal_muscle_relaxation1.46300817
66MP0002272_abnormal_nervous_system1.46009828
67MP0005083_abnormal_biliary_tract1.45919927
68MP0002998_abnormal_bone_remodeling1.42534322
69MP0001970_abnormal_pain_threshold1.41067221
70MP0003221_abnormal_cardiomyocyte_apopto1.38249772
71MP0001835_abnormal_antigen_presentation1.37465184
72MP0000955_abnormal_spinal_cord1.35991338
73MP0003183_abnormal_peptide_metabolism1.35880237
74MP0005330_cardiomyopathy1.34253526
75MP0005023_abnormal_wound_healing1.33321324
76MP0003137_abnormal_impulse_conducting1.33213296
77MP0005257_abnormal_intraocular_pressure1.31387801
78MP0005375_adipose_tissue_phenotype1.30390442
79MP0000759_abnormal_skeletal_muscle1.29189727
80MP0005000_abnormal_immune_tolerance1.28203900
81MP0004043_abnormal_pH_regulation1.27733886
82MP0009745_abnormal_behavioral_response1.24548472
83MP0001440_abnormal_grooming_behavior1.22649255
84MP0003634_abnormal_glial_cell1.22044475
85MP0008569_lethality_at_weaning1.20977298
86MP0001790_abnormal_immune_system1.20971634
87MP0005387_immune_system_phenotype1.20971634
88MP0010234_abnormal_vibrissa_follicle1.19292208
89MP0005666_abnormal_adipose_tissue1.18728988
90MP0001849_ear_inflammation1.16765829
91MP0004145_abnormal_muscle_electrophysio1.15538108
92MP0003075_altered_response_to1.14404598
93MP0002420_abnormal_adaptive_immunity1.13793753
94MP0001819_abnormal_immune_cell1.13116291
95MP0003763_abnormal_thymus_physiology1.11454698
96MP0002972_abnormal_cardiac_muscle1.11296659
97MP0000767_abnormal_smooth_muscle1.10860158
98MP0002067_abnormal_sensory_capabilities1.09174522
99MP0002736_abnormal_nociception_after1.07865657
100MP0006082_CNS_inflammation1.06949220
101MP0002452_abnormal_antigen_presenting1.06859578
102MP0002723_abnormal_immune_serum1.06557907
103MP0010155_abnormal_intestine_physiology1.06185582
104MP0002234_abnormal_pharynx_morphology1.06143613
105MP0009785_altered_susceptibility_to1.06076306
106MP0009333_abnormal_splenocyte_physiolog1.05936428
107MP0005620_abnormal_muscle_contractility1.05582017
108MP0004085_abnormal_heartbeat1.04858162
109MP0002184_abnormal_innervation1.04346270
110MP0002066_abnormal_motor_capabilities/c1.04281949
111MP0008775_abnormal_heart_ventricle1.04273865
112MP0001800_abnormal_humoral_immune1.03123941
113MP0003448_altered_tumor_morphology1.03091833
114MP0002877_abnormal_melanocyte_morpholog1.02789947
115MP0002572_abnormal_emotion/affect_behav1.02410174
116MP0002060_abnormal_skin_morphology1.01830058
117MP0000750_abnormal_muscle_regeneration1.01396321
118MP0010352_gastrointestinal_tract_polyps1.01371750
119MP0002396_abnormal_hematopoietic_system1.01149866
120MP0002882_abnormal_neuron_morphology0.98726362
121MP0000604_amyloidosis0.96349513
122MP0001348_abnormal_lacrimal_gland0.95695515
123MP0000678_abnormal_parathyroid_gland0.95657409
124MP0006138_congestive_heart_failure0.95290403
125MP0001851_eye_inflammation0.95272588
126MP0003879_abnormal_hair_cell0.94836705
127MP0002106_abnormal_muscle_physiology0.94033854
128MP0002405_respiratory_system_inflammati0.93195078
129MP0001486_abnormal_startle_reflex0.93075753
130MP0004808_abnormal_hematopoietic_stem0.93032278
131MP0005621_abnormal_cell_physiology0.92236043
132MP0002398_abnormal_bone_marrow0.91630730
133MP0003690_abnormal_glial_cell0.90793437
134MP0005275_abnormal_skin_tensile0.90286029
135MP0002796_impaired_skin_barrier0.89706616
136MP0010630_abnormal_cardiac_muscle0.89522091
137MP0001299_abnormal_eye_distance/0.89175446
138MP0001915_intracranial_hemorrhage0.89002896
139MP0002089_abnormal_postnatal_growth/wei0.88868753
140MP0004381_abnormal_hair_follicle0.87409743
141MP0005390_skeleton_phenotype0.86380293
142MP0000778_abnormal_nervous_system0.86295835
143MP0000343_altered_response_to0.85888281
144MP0004142_abnormal_muscle_tone0.84872610
145MP0000716_abnormal_immune_system0.84699675
146MP0002229_neurodegeneration0.83778750
147MP0000537_abnormal_urethra_morphology0.83626467
148MP0001544_abnormal_cardiovascular_syste0.83295892
149MP0005385_cardiovascular_system_phenoty0.83295892
150MP0005386_behavior/neurological_phenoty0.83123671
151MP0004924_abnormal_behavior0.83123671
152MP0002152_abnormal_brain_morphology0.82674513
153MP0001545_abnormal_hematopoietic_system0.82605106
154MP0005397_hematopoietic_system_phenotyp0.82605106
155MP0003633_abnormal_nervous_system0.82382388
156MP0005501_abnormal_skin_physiology0.81652656
157MP0002896_abnormal_bone_mineralization0.81438504
158MP0006276_abnormal_autonomic_nervous0.81076194
159MP0000733_abnormal_muscle_development0.80670750
160MP0006072_abnormal_retinal_apoptosis0.79733622
161MP0004484_altered_response_of0.79194851
162MP0008874_decreased_physiological_sensi0.78223534
163MP0005164_abnormal_response_to0.76507258
164MP0003632_abnormal_nervous_system0.76463138
165MP0001845_abnormal_inflammatory_respons0.75551222
166MP0005423_abnormal_somatic_nervous0.75084778
167MP0003656_abnormal_erythrocyte_physiolo0.73082127
168MP0003631_nervous_system_phenotype0.72848326
169MP0005369_muscle_phenotype0.72086184
170MP0000920_abnormal_myelination0.71707531
171MP0004272_abnormal_basement_membrane0.70066904

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)3.93499154
2Eczematoid dermatitis (HP:0000976)3.74822477
3Termporal pattern (HP:0011008)3.46855535
4Insidious onset (HP:0003587)3.46855535
5Protrusio acetabuli (HP:0003179)3.41017838
6Hyporeflexia of lower limbs (HP:0002600)3.33413152
7Pheochromocytoma (HP:0002666)3.32228566
8Premature rupture of membranes (HP:0001788)3.29666613
9Abnormality of the lower motor neuron (HP:0002366)3.15540562
10Visual hallucinations (HP:0002367)2.99310926
11Action tremor (HP:0002345)2.91975253
12Insomnia (HP:0100785)2.91104607
13Sudden death (HP:0001699)2.86734449
14Bundle branch block (HP:0011710)2.86372003
15Ventricular fibrillation (HP:0001663)2.84159572
16Myotonia (HP:0002486)2.79112184
17Supranuclear gaze palsy (HP:0000605)2.73893257
18Distal lower limb amyotrophy (HP:0008944)2.73583256
19Abnormality of macrophages (HP:0004311)2.72536001
20Neuroendocrine neoplasm (HP:0100634)2.70441343
21Abnormality of skeletal muscle fiber size (HP:0012084)2.68073585
22Distal lower limb muscle weakness (HP:0009053)2.66757416
23Difficulty running (HP:0009046)2.65931359
24Recurrent abscess formation (HP:0002722)2.65519721
25Resting tremor (HP:0002322)2.63689461
26Cellulitis (HP:0100658)2.60589127
27Ankle clonus (HP:0011448)2.60013505
28Rapidly progressive (HP:0003678)2.59310015
29Abnormality of the corticospinal tract (HP:0002492)2.56051347
30Vertebral compression fractures (HP:0002953)2.52491896
31Urinary urgency (HP:0000012)2.51944895
32Recurrent bacterial skin infections (HP:0005406)2.51220151
33Hamartoma of the eye (HP:0010568)2.48755655
34Peritonitis (HP:0002586)2.47711908
35Hypercortisolism (HP:0001578)2.47521170
36Upper limb amyotrophy (HP:0009129)2.46572539
37Distal upper limb amyotrophy (HP:0007149)2.46572539
38Obstructive sleep apnea (HP:0002870)2.46085221
39Focal seizures (HP:0007359)2.41877838
40Centrally nucleated skeletal muscle fibers (HP:0003687)2.41632026
41Depression (HP:0000716)2.40806810
42Neoplasm of the heart (HP:0100544)2.39768404
43Achilles tendon contracture (HP:0001771)2.38701351
44Gingivitis (HP:0000230)2.32183908
45Neoplasm of the peripheral nervous system (HP:0100007)2.31967713
46Broad face (HP:0000283)2.31798457
47Type 1 muscle fiber predominance (HP:0003803)2.31073228
48Dilatation of the ascending aorta (HP:0005111)2.30731425
49Global brain atrophy (HP:0002283)2.30020014
50Abnormality of the Achilles tendon (HP:0005109)2.28055720
51Exercise-induced myalgia (HP:0003738)2.27759352
52Muscle fiber splitting (HP:0003555)2.27374150
53Difficulty climbing stairs (HP:0003551)2.26344057
54Hand muscle atrophy (HP:0009130)2.25635499
55Cerebral inclusion bodies (HP:0100314)2.23251564
56Arterial tortuosity (HP:0005116)2.20593636
57Focal motor seizures (HP:0011153)2.18772203
58Fragile skin (HP:0001030)2.17791238
59Spontaneous hematomas (HP:0007420)2.15653884
60Myoglobinuria (HP:0002913)2.15524886
61Recurrent gram-negative bacterial infections (HP:0005420)2.15268542
62Genu recurvatum (HP:0002816)2.14541032
63EMG: neuropathic changes (HP:0003445)2.14418740
64Vascular tortuosity (HP:0004948)2.13965433
65Spastic gait (HP:0002064)2.13788917
66Disproportionate tall stature (HP:0001519)2.13078370
67Hammertoe (HP:0001765)2.09922360
68Cervical subluxation (HP:0003308)2.09238816
69Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.09010215
70Lower limb amyotrophy (HP:0007210)2.07891518
71Spinal rigidity (HP:0003306)2.07041053
72Progressive sensorineural hearing impairment (HP:0000408)2.05722509
73Atrophic scars (HP:0001075)2.05566919
74Increased connective tissue (HP:0009025)2.05554945
75Dysmetric saccades (HP:0000641)2.05384386
76Increased IgE level (HP:0003212)2.05170677
77Cholelithiasis (HP:0001081)2.04355178
78Adenoma sebaceum (HP:0009720)2.02873287
79Angiofibromas (HP:0010615)2.02873287
80Urinary bladder sphincter dysfunction (HP:0002839)2.02817093
81Myositis (HP:0100614)2.02579128
82Ulnar bowing (HP:0003031)2.02404490
83Impaired social interactions (HP:0000735)2.00546889
84Abnormal social behavior (HP:0012433)2.00546889
85Blue sclerae (HP:0000592)2.00443786
86Aneurysm (HP:0002617)2.00176134
87Back pain (HP:0003418)1.98841932
88Mildly elevated creatine phosphokinase (HP:0008180)1.98646127
89Athetosis (HP:0002305)1.98199309
90Mitral regurgitation (HP:0001653)1.97326892
91Thin bony cortex (HP:0002753)1.96996765
92Polycythemia (HP:0001901)1.96008255
93Atonic seizures (HP:0010819)1.95596898
94Flat acetabular roof (HP:0003180)1.95586810
95Lymphangioma (HP:0100764)1.95310489
96Impaired vibration sensation in the lower limbs (HP:0002166)1.94511320
97Turricephaly (HP:0000262)1.93940351
98Hemiplegia (HP:0002301)1.93817930
99Aortic aneurysm (HP:0004942)1.93783025
100Lower limb muscle weakness (HP:0007340)1.91940457
101Obstructive lung disease (HP:0006536)1.91664145
102Chronic obstructive pulmonary disease (HP:0006510)1.91664145
103Gastrointestinal infarctions (HP:0005244)1.90190300
104Increased variability in muscle fiber diameter (HP:0003557)1.89924226
105Degeneration of the lateral corticospinal tracts (HP:0002314)1.89494785
106Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89494785
107Megalencephaly (HP:0001355)1.89088859
108Diaphragmatic weakness (HP:0009113)1.88791396
109Orchitis (HP:0100796)1.88542531
110Cerebral aneurysm (HP:0004944)1.88522784
111Atrioventricular block (HP:0001678)1.88375795
112Ventricular tachycardia (HP:0004756)1.87583123
113Right ventricular cardiomyopathy (HP:0011663)1.86797174
114Ketoacidosis (HP:0001993)1.86177499
115Exercise-induced muscle cramps (HP:0003710)1.85726487
116Ulnar claw (HP:0001178)1.85579040
117Neurofibrillary tangles (HP:0002185)1.85052351
118Conjunctival hamartoma (HP:0100780)1.84953426
119Heart block (HP:0012722)1.84841568
120Foot dorsiflexor weakness (HP:0009027)1.84497348
121Metaphyseal cupping (HP:0003021)1.83472600
122Shallow orbits (HP:0000586)1.82671285
123Abnormal gallbladder morphology (HP:0012437)1.82252508
124Reticulocytosis (HP:0001923)1.81742147
125Intention tremor (HP:0002080)1.81373078
126Segmental peripheral demyelination/remyelination (HP:0003481)1.81265515
127Impaired pain sensation (HP:0007328)1.80587667
128Abnormality of pain sensation (HP:0010832)1.80587667
129Wormian bones (HP:0002645)1.79565831
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.79408331
131Osteolytic defects of the hand bones (HP:0009699)1.79408331
132Abnormal gallbladder physiology (HP:0012438)1.79244260
133Cholecystitis (HP:0001082)1.79244260
134Gout (HP:0001997)1.79042599
135Aortic dissection (HP:0002647)1.78318353
136Anxiety (HP:0000739)1.76945220
137Hemorrhage of the eye (HP:0011885)1.76578095
138Syringomyelia (HP:0003396)1.76296608
139Spinal cord lesions (HP:0100561)1.76296608
140Postural instability (HP:0002172)1.75949440
141Syncope (HP:0001279)1.75598280
142Abnormality of the foot musculature (HP:0001436)1.75462986
143Absence seizures (HP:0002121)1.75193800
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75153810
145Fibroma (HP:0010614)1.74940846
146Ankle contracture (HP:0006466)1.74527795
147Pointed chin (HP:0000307)1.73913014
148Mitral valve prolapse (HP:0001634)1.73397528
149Slender build (HP:0001533)1.73286123
150Asymmetric septal hypertrophy (HP:0001670)1.72944956
151Amyloidosis (HP:0011034)1.72757954
152Long palpebral fissure (HP:0000637)1.72650390
153Abnormal atrioventricular conduction (HP:0005150)1.72445832
154Myopathic facies (HP:0002058)1.70668119
155Onion bulb formation (HP:0003383)1.69985748
156Distal sensory impairment (HP:0002936)1.69442990
157Polygenic inheritance (HP:0010982)1.69426116
158Abnormal platelet volume (HP:0011876)1.69354600
159Interstitial pulmonary disease (HP:0006530)1.68920783
160Poor eye contact (HP:0000817)1.68662845
161Slow saccadic eye movements (HP:0000514)1.68507999
162Short nail (HP:0001799)1.68121347
163Mediastinal lymphadenopathy (HP:0100721)1.67748699
164Dysostosis multiplex (HP:0000943)1.67048853
165Ventricular arrhythmia (HP:0004308)1.67023092
166EMG: myopathic abnormalities (HP:0003458)1.67006478
167Ankyloglossia (HP:0010296)1.65803282
168Subacute progressive viral hepatitis (HP:0006572)1.65415456
169Increased cerebral lipofuscin (HP:0011813)1.65204958
170Skin nodule (HP:0200036)1.64725093
171Hyperacusis (HP:0010780)1.64473883
172Bladder diverticulum (HP:0000015)1.63063826
173Decreased motor nerve conduction velocity (HP:0003431)1.59281357
174Abnormality of the peritoneum (HP:0002585)1.58728771
175Biconcave vertebral bodies (HP:0004586)1.58513280
176Urticaria (HP:0001025)1.58507820
177Abnormality of the nasal mucosa (HP:0000433)1.57878975
178Upper motor neuron abnormality (HP:0002127)1.57435044
179Emphysema (HP:0002097)1.56202316
180Joint laxity (HP:0001388)1.55847902

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.86119082
2PRPF4B3.44572253
3MAP2K32.60057717
4MAP3K92.56423528
5SMG12.50482285
6RIPK42.40300358
7NTRK12.37925144
8KSR22.34024614
9PKN22.28473878
10LATS22.28330570
11PAK62.20591172
12TTN1.98911836
13MAP3K41.98671189
14MINK11.97947015
15LMTK21.92530324
16RIPK11.91907366
17MAP2K41.87139421
18EEF2K1.84479715
19MAP3K101.72085640
20MAP3K131.70181751
21EPHB11.65790972
22MAP3K31.64278532
23RET1.63440190
24IRAK31.58536653
25CDK121.57485408
26PHKG11.52969919
27PHKG21.52969919
28NEK11.51163478
29NTRK31.46705385
30MAPKAPK31.44764352
31IRAK41.44750714
32PDGFRA1.44401943
33ZAP701.42513495
34ALK1.39980377
35TAOK21.39179639
36MAP3K21.39125637
37PRKD31.38077429
38PAK31.37490950
39MARK11.34157492
40TYK21.33018064
41PRKD21.32563716
42MAP4K11.32037257
43UHMK11.31948841
44BLK1.28459542
45CSK1.27327913
46TYRO31.26809798
47LIMK11.24624470
48MAP3K111.23069386
49STK381.22077976
50BCKDK1.21563902
51PAK41.17553566
52SCYL21.15422151
53MAP3K61.10763442
54ICK1.10580367
55DAPK21.09701534
56TAOK11.09470719
57EPHA21.06324636
58MARK21.05184739
59SIK11.04434506
60CAMKK11.04016362
61PTK21.03850406
62ARAF1.01199169
63CDK50.99512246
64WNK10.98496516
65PDK30.96840093
66PDK40.96840093
67WNK40.96680732
68FES0.94571187
69FER0.92795540
70CDK140.92642834
71JAK30.92255256
72FGFR20.91350418
73MAP3K140.91330764
74GRK60.91255069
75CDK150.86738816
76NTRK20.86736906
77MTOR0.85094793
78MAP3K10.84760477
79KSR10.84013516
80HCK0.83985761
81TBK10.83542685
82MAP2K10.83006428
83MOS0.82915725
84CDK180.82474814
85FGR0.80934783
86MAP3K70.80627468
87RPS6KA20.80614456
88CDK11A0.77768029
89GRK50.77128320
90TESK20.75715964
91IRAK20.74009523
92TESK10.73965092
93FGFR10.73046319
94BTK0.72110605
95TNK20.70886224
96BRSK10.70837148
97MET0.70683613
98BMX0.70366265
99PAK20.69932741
100PRKCH0.69172193
101PDK10.68686647
102JAK10.68471158
103SIK30.68338519
104PRKG20.68297409
105RPS6KC10.66785294
106RPS6KL10.66785294
107CDC42BPA0.66458336
108MAP3K80.65830769
109PTK60.64772666
110SGK30.64591223
111PRKD10.63655877
112DMPK0.63614183
113PRKAA10.63080714
114ERN10.62350606
115JAK20.61555941
116TGFBR20.61247878
117ERBB20.59091507
118CAMK1G0.57922536
119LRRK20.57134780
120STK110.55922134
121MST1R0.55397775
122MAP2K70.53169765
123PDPK10.53101461
124RAF10.52904508
125EPHB20.51879327
126ILK0.51751807
127DDR20.51291456
128CAMKK20.50906229
129DYRK1B0.48802706
130PNCK0.48199731
131MAP2K20.47991045
132FGFR40.47781080
133NEK90.46007059
134SIK20.45802532
135BRAF0.45078820
136MAPK120.44964392
137CSF1R0.43915275
138MAPK70.43767420
139CDK190.43601684
140ROCK10.43308739
141MAPK110.43292488
142PTK2B0.43245230
143PDGFRB0.43241258
144ROCK20.42989991
145FGFR30.42791888
146RPS6KA60.42708671
147HIPK20.40916762
148SGK4940.40379926
149SGK2230.40379926
150YES10.39636921
151DAPK30.39477063
152STK390.39366987
153FYN0.39333053

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.84825296
2Synaptic vesicle cycle_Homo sapiens_hsa047212.49745657
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.48066646
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.42987541
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.40484223
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90360934
7Osteoclast differentiation_Homo sapiens_hsa043801.87012418
8Other glycan degradation_Homo sapiens_hsa005111.83776551
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.83675255
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83667120
11Acute myeloid leukemia_Homo sapiens_hsa052211.82551148
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80895894
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80776796
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77356441
15Nitrogen metabolism_Homo sapiens_hsa009101.71985110
16B cell receptor signaling pathway_Homo sapiens_hsa046621.68548373
17Pancreatic cancer_Homo sapiens_hsa052121.53066952
18Leishmaniasis_Homo sapiens_hsa051401.50432604
19Insulin secretion_Homo sapiens_hsa049111.45445802
20Butanoate metabolism_Homo sapiens_hsa006501.44277494
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.43642645
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41049196
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39533295
24GABAergic synapse_Homo sapiens_hsa047271.36797712
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36607497
26Carbon metabolism_Homo sapiens_hsa012001.34753782
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34286475
28Cardiac muscle contraction_Homo sapiens_hsa042601.34286403
29Long-term potentiation_Homo sapiens_hsa047201.33658092
30Notch signaling pathway_Homo sapiens_hsa043301.32264007
31Dopaminergic synapse_Homo sapiens_hsa047281.31480356
32Type II diabetes mellitus_Homo sapiens_hsa049301.29147766
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.26960334
34Focal adhesion_Homo sapiens_hsa045101.26671280
35Gap junction_Homo sapiens_hsa045401.23661908
36Gastric acid secretion_Homo sapiens_hsa049711.23315855
37Pyruvate metabolism_Homo sapiens_hsa006201.23294052
38mTOR signaling pathway_Homo sapiens_hsa041501.23177793
39Amoebiasis_Homo sapiens_hsa051461.22498537
40Glioma_Homo sapiens_hsa052141.21203254
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19308163
42Circadian entrainment_Homo sapiens_hsa047131.18582254
43Tuberculosis_Homo sapiens_hsa051521.18469770
44Fatty acid metabolism_Homo sapiens_hsa012121.18135288
45Cholinergic synapse_Homo sapiens_hsa047251.17618795
46Insulin signaling pathway_Homo sapiens_hsa049101.16481294
47Dilated cardiomyopathy_Homo sapiens_hsa054141.16213437
48Toxoplasmosis_Homo sapiens_hsa051451.14975442
49VEGF signaling pathway_Homo sapiens_hsa043701.11059117
50Malaria_Homo sapiens_hsa051441.10899117
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10758306
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09896865
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09872545
54Nicotine addiction_Homo sapiens_hsa050331.09366653
55Thyroid cancer_Homo sapiens_hsa052161.08829799
56Biosynthesis of amino acids_Homo sapiens_hsa012301.07967042
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07925599
58Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07752780
59Propanoate metabolism_Homo sapiens_hsa006401.07504390
60AMPK signaling pathway_Homo sapiens_hsa041521.07063311
61Hepatitis C_Homo sapiens_hsa051601.06262536
62Estrogen signaling pathway_Homo sapiens_hsa049151.05746293
63Shigellosis_Homo sapiens_hsa051311.05248526
64Neurotrophin signaling pathway_Homo sapiens_hsa047221.04925367
65Salivary secretion_Homo sapiens_hsa049701.04235549
66Glucagon signaling pathway_Homo sapiens_hsa049221.03525836
67Chemokine signaling pathway_Homo sapiens_hsa040621.03503126
68Proteoglycans in cancer_Homo sapiens_hsa052051.03459458
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03336495
70Oxytocin signaling pathway_Homo sapiens_hsa049211.02562507
71Hepatitis B_Homo sapiens_hsa051611.02495973
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01989824
73Prion diseases_Homo sapiens_hsa050201.01314300
74Bile secretion_Homo sapiens_hsa049761.01008220
75Platelet activation_Homo sapiens_hsa046111.00078306
76TNF signaling pathway_Homo sapiens_hsa046680.99530397
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99355096
78GnRH signaling pathway_Homo sapiens_hsa049120.98270378
79Apoptosis_Homo sapiens_hsa042100.97884381
80Arginine biosynthesis_Homo sapiens_hsa002200.97563541
81Prolactin signaling pathway_Homo sapiens_hsa049170.97394388
82Glutamatergic synapse_Homo sapiens_hsa047240.97374554
83Fatty acid degradation_Homo sapiens_hsa000710.97073079
84Salmonella infection_Homo sapiens_hsa051320.96881714
85Olfactory transduction_Homo sapiens_hsa047400.96349013
86T cell receptor signaling pathway_Homo sapiens_hsa046600.96304142
87Long-term depression_Homo sapiens_hsa047300.95544137
88Influenza A_Homo sapiens_hsa051640.95191608
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94008645
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92956925
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.91553452
92Small cell lung cancer_Homo sapiens_hsa052220.91377727
93Insulin resistance_Homo sapiens_hsa049310.90823758
94Morphine addiction_Homo sapiens_hsa050320.90597708
95Renal cell carcinoma_Homo sapiens_hsa052110.89082551
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87960662
97Inositol phosphate metabolism_Homo sapiens_hsa005620.87954922
98Measles_Homo sapiens_hsa051620.87349247
99Renin secretion_Homo sapiens_hsa049240.86989290
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86750295
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86470180
102Choline metabolism in cancer_Homo sapiens_hsa052310.85091485
103Phagosome_Homo sapiens_hsa041450.84526502
104Staphylococcus aureus infection_Homo sapiens_hsa051500.83920691
105Colorectal cancer_Homo sapiens_hsa052100.83742553
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82005038
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81977804
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81732582
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.79959839
110ErbB signaling pathway_Homo sapiens_hsa040120.79744848
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79553491
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79407397
113Lysosome_Homo sapiens_hsa041420.79206325
114Fatty acid biosynthesis_Homo sapiens_hsa000610.78874769
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78787839
116Rap1 signaling pathway_Homo sapiens_hsa040150.78587991
117Adherens junction_Homo sapiens_hsa045200.78345805
118Prostate cancer_Homo sapiens_hsa052150.76807923
119Collecting duct acid secretion_Homo sapiens_hsa049660.76794597
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75656576
121HIF-1 signaling pathway_Homo sapiens_hsa040660.75310601
122Amphetamine addiction_Homo sapiens_hsa050310.75148704
123Endometrial cancer_Homo sapiens_hsa052130.75025014
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.74864660
125Viral myocarditis_Homo sapiens_hsa054160.74852718
126Tight junction_Homo sapiens_hsa045300.74469651
127Oocyte meiosis_Homo sapiens_hsa041140.73498144
128FoxO signaling pathway_Homo sapiens_hsa040680.73316803
129Vibrio cholerae infection_Homo sapiens_hsa051100.71840707
130Pentose phosphate pathway_Homo sapiens_hsa000300.71808753
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71455033
132Endocytosis_Homo sapiens_hsa041440.70703867
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68781258
134Fructose and mannose metabolism_Homo sapiens_hsa000510.68176248
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.68130002
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67806424
137ECM-receptor interaction_Homo sapiens_hsa045120.67719069
138Viral carcinogenesis_Homo sapiens_hsa052030.67512192
139Pertussis_Homo sapiens_hsa051330.67464874
140Melanogenesis_Homo sapiens_hsa049160.67441229
141Non-small cell lung cancer_Homo sapiens_hsa052230.67166578
142PPAR signaling pathway_Homo sapiens_hsa033200.67070696
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.66542140
144Axon guidance_Homo sapiens_hsa043600.64975503
145Galactose metabolism_Homo sapiens_hsa000520.64875946
146MAPK signaling pathway_Homo sapiens_hsa040100.64293039
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63976572
148MicroRNAs in cancer_Homo sapiens_hsa052060.62153088
149Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61884198
150Jak-STAT signaling pathway_Homo sapiens_hsa046300.61870517
151Dorso-ventral axis formation_Homo sapiens_hsa043200.60164448
152Bladder cancer_Homo sapiens_hsa052190.59188403
153Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59135691
154Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59095869
155Thyroid hormone synthesis_Homo sapiens_hsa049180.58640136
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.58430633
157Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57956064
158HTLV-I infection_Homo sapiens_hsa051660.57828658
159NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57288095
160Parkinsons disease_Homo sapiens_hsa050120.57139346
161Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56729375
162Fatty acid elongation_Homo sapiens_hsa000620.55979038
163Caffeine metabolism_Homo sapiens_hsa002320.54434666
164cAMP signaling pathway_Homo sapiens_hsa040240.53957675
165Cyanoamino acid metabolism_Homo sapiens_hsa004600.53727449
166Pancreatic secretion_Homo sapiens_hsa049720.53561962
167Chronic myeloid leukemia_Homo sapiens_hsa052200.53022020
168Hippo signaling pathway_Homo sapiens_hsa043900.51366475

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