SH3D19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.30661701
2L-phenylalanine catabolic process (GO:0006559)5.30661701
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.08645180
4L-phenylalanine metabolic process (GO:0006558)5.08645180
5sulfur amino acid catabolic process (GO:0000098)4.55392386
6aromatic amino acid family catabolic process (GO:0009074)4.52762587
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.45829153
8cysteine metabolic process (GO:0006534)4.42326385
9homocysteine metabolic process (GO:0050667)4.36296487
10alpha-linolenic acid metabolic process (GO:0036109)4.33927865
11glyoxylate metabolic process (GO:0046487)4.23327383
12bile acid biosynthetic process (GO:0006699)4.10267329
13negative regulation of fibrinolysis (GO:0051918)4.10052448
14urea cycle (GO:0000050)4.06709735
15urea metabolic process (GO:0019627)4.06709735
16regulation of protein activation cascade (GO:2000257)4.04170097
17peptidyl-glutamic acid carboxylation (GO:0017187)4.03527323
18protein carboxylation (GO:0018214)4.03527323
19kynurenine metabolic process (GO:0070189)3.99542575
20regulation of fibrinolysis (GO:0051917)3.94036106
21complement activation, alternative pathway (GO:0006957)3.93239349
22high-density lipoprotein particle remodeling (GO:0034375)3.90133814
23indole-containing compound catabolic process (GO:0042436)3.88515415
24indolalkylamine catabolic process (GO:0046218)3.88515415
25tryptophan catabolic process (GO:0006569)3.88515415
26regulation of complement activation (GO:0030449)3.86382169
27intestinal cholesterol absorption (GO:0030299)3.81977930
28regulation of cholesterol homeostasis (GO:2000188)3.77914388
29tryptophan metabolic process (GO:0006568)3.73138414
30nitrogen cycle metabolic process (GO:0071941)3.69941683
31regulation of triglyceride catabolic process (GO:0010896)3.68163071
32reverse cholesterol transport (GO:0043691)3.65153067
33bile acid metabolic process (GO:0008206)3.63525682
34hemidesmosome assembly (GO:0031581)3.63361929
35serine family amino acid catabolic process (GO:0009071)3.60111771
36amino-acid betaine metabolic process (GO:0006577)3.59386278
37cellular glucuronidation (GO:0052695)3.57674849
38lysine metabolic process (GO:0006553)3.54896401
39lysine catabolic process (GO:0006554)3.54896401
40triglyceride homeostasis (GO:0070328)3.54707547
41acylglycerol homeostasis (GO:0055090)3.54707547
42phospholipid efflux (GO:0033700)3.51648042
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.50820807
44negative regulation of cholesterol transport (GO:0032375)3.47940262
45negative regulation of sterol transport (GO:0032372)3.47940262
46drug catabolic process (GO:0042737)3.47423929
47positive regulation of fatty acid beta-oxidation (GO:0032000)3.46170746
48desmosome organization (GO:0002934)3.45793362
49bile acid and bile salt transport (GO:0015721)3.43176164
50fibrinolysis (GO:0042730)3.41304245
51epoxygenase P450 pathway (GO:0019373)3.39545600
52ethanol oxidation (GO:0006069)3.38081123
53response to nitrosative stress (GO:0051409)3.34035963
54intestinal absorption (GO:0050892)3.33877434
55regulation of bile acid biosynthetic process (GO:0070857)3.33642870
56cellular modified amino acid catabolic process (GO:0042219)3.28562709
57plasma lipoprotein particle clearance (GO:0034381)3.28461579
58plasma lipoprotein particle remodeling (GO:0034369)3.26791203
59protein-lipid complex remodeling (GO:0034368)3.26791203
60macromolecular complex remodeling (GO:0034367)3.26791203
61lipoprotein metabolic process (GO:0042157)3.25223699
62regulation of cholesterol esterification (GO:0010872)3.24803600
63tyrosine metabolic process (GO:0006570)3.24078681
64cholesterol efflux (GO:0033344)3.23976144
65aromatic amino acid family metabolic process (GO:0009072)3.22532478
66cholesterol homeostasis (GO:0042632)3.22251808
67gap junction assembly (GO:0016264)3.20400153
68sterol homeostasis (GO:0055092)3.19638007
69hormone catabolic process (GO:0042447)3.18307193
70positive regulation of lipid catabolic process (GO:0050996)3.13292475
71glucuronate metabolic process (GO:0019585)3.11972368
72uronic acid metabolic process (GO:0006063)3.11972368
73very-low-density lipoprotein particle assembly (GO:0034379)3.10876836
74glutamate metabolic process (GO:0006536)3.10647214
75alpha-amino acid catabolic process (GO:1901606)3.09720648
76plasma lipoprotein particle assembly (GO:0034377)3.09267697
77drug transmembrane transport (GO:0006855)3.09171911
78negative regulation of lipase activity (GO:0060192)3.08891081
79regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.07023809
80epithelial cell-cell adhesion (GO:0090136)3.05438361
81retina vasculature morphogenesis in camera-type eye (GO:0061299)3.05192171
82ethanol metabolic process (GO:0006067)3.03872454
83negative regulation of fatty acid transport (GO:2000192)3.03520233
84regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.02975166
85regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.00977790
86serine family amino acid metabolic process (GO:0009069)2.99145684
87coenzyme catabolic process (GO:0009109)2.98586818
88phospholipid homeostasis (GO:0055091)2.98539882
89benzene-containing compound metabolic process (GO:0042537)2.97394793
90cellular amino acid catabolic process (GO:0009063)2.96076916
91chondrocyte proliferation (GO:0035988)2.94295680
92positive regulation of lipoprotein lipase activity (GO:0051006)2.94053382
93positive regulation of triglyceride lipase activity (GO:0061365)2.94053382
94regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.94040563
95paraxial mesoderm development (GO:0048339)2.93308293
96midgut development (GO:0007494)2.92919489
97skin morphogenesis (GO:0043589)2.91647802
98protein-lipid complex assembly (GO:0065005)2.91447722
99NADH metabolic process (GO:0006734)2.91272417
100negative regulation of protein activation cascade (GO:2000258)2.90607457
101cellular ketone body metabolic process (GO:0046950)2.90412102
102bundle of His cell to Purkinje myocyte communication (GO:0086069)2.88078085
103endothelial cell morphogenesis (GO:0001886)2.85308290
104exogenous drug catabolic process (GO:0042738)2.85063666
105glycine metabolic process (GO:0006544)2.83499913
106endocardial cushion development (GO:0003197)2.83162306
107flavonoid metabolic process (GO:0009812)2.83125299
108acetyl-CoA metabolic process (GO:0006084)2.82214067
109short-chain fatty acid metabolic process (GO:0046459)2.81828464
110regulation of plasminogen activation (GO:0010755)2.80655445
111carnitine metabolic process (GO:0009437)2.80600277
112xenobiotic catabolic process (GO:0042178)2.80077480
113imidazole-containing compound metabolic process (GO:0052803)2.79751038
114very long-chain fatty acid metabolic process (GO:0000038)2.79096210
115sequestering of extracellular ligand from receptor (GO:0035581)2.76437816
116cell-substrate junction assembly (GO:0007044)2.76365832
117COPII vesicle coating (GO:0048208)2.72843824
118collagen fibril organization (GO:0030199)2.70547545
119embryonic retina morphogenesis in camera-type eye (GO:0060059)2.66479495
120surfactant homeostasis (GO:0043129)2.66426184
121extracellular matrix assembly (GO:0085029)2.65991137
122basement membrane organization (GO:0071711)2.62953774
123extracellular fibril organization (GO:0043206)2.61179736
124endodermal cell differentiation (GO:0035987)2.59922536
125regulation of cardioblast differentiation (GO:0051890)2.59257588
126transcytosis (GO:0045056)2.57495696
127primary alcohol catabolic process (GO:0034310)2.56910179
128regulation of apoptotic cell clearance (GO:2000425)2.53597761
129cell adhesion mediated by integrin (GO:0033627)2.51631276
130regulation of transforming growth factor beta2 production (GO:0032909)2.51306405
131negative regulation of complement activation (GO:0045916)2.48468644
132vascular endothelial growth factor signaling pathway (GO:0038084)2.48361305
133glomerular filtration (GO:0003094)2.47764760
134renal filtration (GO:0097205)2.45023113
135renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.44871887
136low-density lipoprotein particle clearance (GO:0034383)2.43255539
137protein localization to cell surface (GO:0034394)2.42700029
138negative regulation of chondrocyte differentiation (GO:0032331)2.41572359
139adherens junction assembly (GO:0034333)2.40728228
140notochord development (GO:0030903)2.40096993
141positive regulation of endothelial cell apoptotic process (GO:2000353)2.38975343
142lymphangiogenesis (GO:0001946)2.37258265
143focal adhesion assembly (GO:0048041)2.34938575
144cell-substrate adherens junction assembly (GO:0007045)2.34938575
145renal system process involved in regulation of blood volume (GO:0001977)2.34620854
146chemical homeostasis within a tissue (GO:0048875)2.33040862
147fibril organization (GO:0097435)2.31464535
148regulation of transforming growth factor beta1 production (GO:0032908)2.29294126
149regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.29029439
150lipoprotein transport (GO:0042953)2.28825391
151regulation of tight junction assembly (GO:2000810)2.27806891
152apoptotic cell clearance (GO:0043277)2.26994992
153angiotensin maturation (GO:0002003)2.25171945
154protein heterotrimerization (GO:0070208)2.23951532
155glomerular basement membrane development (GO:0032836)2.23855732
156anterior/posterior axis specification, embryo (GO:0008595)2.23483939
157triglyceride catabolic process (GO:0019433)2.23202697
158substrate adhesion-dependent cell spreading (GO:0034446)2.23172025
159cardiac myofibril assembly (GO:0055003)2.22955118
160cell migration involved in heart development (GO:0060973)2.22915469
161insulin-like growth factor receptor signaling pathway (GO:0048009)2.22387851
162lung lobe morphogenesis (GO:0060463)2.22272419
163negative regulation of blood coagulation (GO:0030195)2.21573887
164negative regulation of hemostasis (GO:1900047)2.21573887
165hippo signaling (GO:0035329)2.21180241
166carnitine shuttle (GO:0006853)2.20088887
167negative regulation of keratinocyte proliferation (GO:0010839)2.19870183
168acylglycerol catabolic process (GO:0046464)2.18837675
169neutral lipid catabolic process (GO:0046461)2.18837675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.90757506
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.11770074
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.07603024
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.48250347
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.31027677
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.59766761
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.44444432
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.18947282
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.04674361
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.01233148
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.83250943
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.30802208
13CLOCK_20551151_ChIP-Seq_293T_Human2.30073156
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.21612733
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.20213054
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10596002
17SOX2_27498859_Chip-Seq_STOMACH_Mouse1.85497594
18AR_21909140_ChIP-Seq_LNCAP_Human1.83953438
19FOXO3_23340844_ChIP-Seq_DLD1_Human1.76910508
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76484756
21CTNNB1_20460455_ChIP-Seq_HCT116_Human1.73547170
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.70267592
23ZNF263_19887448_ChIP-Seq_K562_Human1.66681793
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66428915
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63671123
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.62658556
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62056913
28SOX9_24532713_ChIP-Seq_HFSC_Mouse1.59636614
29GATA4_25053715_ChIP-Seq_YYC3_Human1.55733623
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.51768113
31SOX2_20726797_ChIP-Seq_SW620_Human1.46610799
32NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45375068
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42789447
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42712594
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41903991
36PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.34013923
37* CJUN_26792858_Chip-Seq_BT549_Human1.33990794
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33188319
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31310413
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31188838
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31178080
42BRD4_25478319_ChIP-Seq_HGPS_Human1.28781314
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.27559000
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27242259
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27031638
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27031638
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23998425
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23790929
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23790929
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23683851
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23532562
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22301225
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22146020
54* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21166692
55GATA6_25053715_ChIP-Seq_YYC3_Human1.19823567
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18135048
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17632801
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.16898769
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16166162
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15444893
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14541157
62SMAD3_21741376_ChIP-Seq_HESCs_Human1.14443402
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13568751
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13093191
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09693125
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08973322
67* HNF4A_19822575_ChIP-Seq_HepG2_Human1.08609015
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08520624
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07517134
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.06925493
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06300961
72SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05720949
73AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05096780
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04989133
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04984970
76AHR_22903824_ChIP-Seq_MCF-7_Human1.04243837
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03173971
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02579590
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02402551
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01970188
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01970188
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01970188
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01743325
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01308172
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01261987
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00659536
87RACK7_27058665_Chip-Seq_MCF-7_Human0.99749719
88ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99313510
89RUNX1_27514584_Chip-Seq_MCF-7_Human0.98992777
90TP63_23658742_ChIP-Seq_EP156T_Human0.98878559
91CDX2_22108803_ChIP-Seq_LS180_Human0.97835701
92GATA3_24758297_ChIP-Seq_MCF-7_Human0.97548320
93FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95646197
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93749964
95PIAS1_25552417_ChIP-Seq_VCAP_Human0.93638380
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93536330
97TCF4_18268006_ChIP-ChIP_LS174T_Human0.91785105
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91449483
99TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90701193
100ATF3_27146783_Chip-Seq_COLON_Human0.90698705
101TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90151536
102EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90147536
103YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89274168
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89191017
105TP53_16413492_ChIP-PET_HCT116_Human0.89125764
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88586625
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87515348
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84535740
109P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83657748
110FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83467818
111KLF5_25053715_ChIP-Seq_YYC3_Human0.82906708
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.82815210
113BCAT_22108803_ChIP-Seq_LS180_Human0.81505596
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.81121345
115ISL1_27105846_Chip-Seq_CPCs_Mouse0.78464864
116TBX20_22328084_ChIP-Seq_HEART_Mouse0.76791791
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.76791791
118TP53_18474530_ChIP-ChIP_U2OS_Human0.76615654
119* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75324074
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75250476
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.74584145
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.74581389
123* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74027987
124TCF3_18692474_ChIP-Seq_MESCs_Mouse0.73790272

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.75447832
2MP0005360_urolithiasis5.69854579
3MP0005085_abnormal_gallbladder_physiolo4.43820211
4MP0005365_abnormal_bile_salt4.00948424
5MP0003252_abnormal_bile_duct3.50132294
6MP0008875_abnormal_xenobiotic_pharmacok3.43788162
7MP0003705_abnormal_hypodermis_morpholog3.10476756
8MP0010234_abnormal_vibrissa_follicle2.67565497
9MP0001666_abnormal_nutrient_absorption2.57534692
10MP0005275_abnormal_skin_tensile2.50650942
11MP0005670_abnormal_white_adipose2.48583402
12MP0003806_abnormal_nucleotide_metabolis2.42753543
13MP0008438_abnormal_cutaneous_collagen2.38052077
14MP0010329_abnormal_lipoprotein_level2.36382495
15MP0002796_impaired_skin_barrier2.33388538
16MP0000751_myopathy2.10021238
17MP0003950_abnormal_plasma_membrane2.03501395
18MP0003195_calcinosis1.97810778
19MP0005083_abnormal_biliary_tract1.97326141
20MP0003279_aneurysm1.94697630
21MP0004019_abnormal_vitamin_homeostasis1.94622486
22MP0002254_reproductive_system_inflammat1.86602920
23MP0005332_abnormal_amino_acid1.86162552
24MP0002060_abnormal_skin_morphology1.86140475
25MP0004272_abnormal_basement_membrane1.84800909
26MP0009384_cardiac_valve_regurgitation1.82360706
27MP0006138_congestive_heart_failure1.80616774
28MP0009840_abnormal_foam_cell1.76114818
29MP0005409_darkened_coat_color1.75525237
30MP0004084_abnormal_cardiac_muscle1.73261547
31MP0010678_abnormal_skin_adnexa1.69352165
32MP0004264_abnormal_extraembryonic_tissu1.59532564
33MP0000537_abnormal_urethra_morphology1.58975544
34MP0002138_abnormal_hepatobiliary_system1.54522168
35MP0000383_abnormal_hair_follicle1.50594891
36MP0009053_abnormal_anal_canal1.48695379
37MP0003941_abnormal_skin_development1.47190356
38MP0003191_abnormal_cellular_cholesterol1.43273495
39MP0002118_abnormal_lipid_homeostasis1.39265610
40MP0005501_abnormal_skin_physiology1.35727053
41MP0000579_abnormal_nail_morphology1.35610348
42MP0003453_abnormal_keratinocyte_physiol1.35564796
43MP0001879_abnormal_lymphatic_vessel1.35466437
44MP0000767_abnormal_smooth_muscle1.33549515
45MP0000609_abnormal_liver_physiology1.31135042
46MP0002098_abnormal_vibrissa_morphology1.29307385
47MP0005503_abnormal_tendon_morphology1.28375517
48MP0003566_abnormal_cell_adhesion1.20729324
49MP0004036_abnormal_muscle_relaxation1.20370854
50MP0005330_cardiomyopathy1.19793421
51MP0000467_abnormal_esophagus_morphology1.19667671
52MP0000462_abnormal_digestive_system1.18414610
53MP0003091_abnormal_cell_migration1.16762813
54MP0005375_adipose_tissue_phenotype1.16128678
55MP0000566_synostosis1.15004051
56MP0004215_abnormal_myocardial_fiber1.13550454
57MP0001299_abnormal_eye_distance/1.12435299
58MP0003868_abnormal_feces_composition1.11791773
59MP0000013_abnormal_adipose_tissue1.10780090
60MP0004087_abnormal_muscle_fiber1.09462970
61MP0000003_abnormal_adipose_tissue1.09260789
62MP0001216_abnormal_epidermal_layer1.08461470
63MP0009643_abnormal_urine_homeostasis1.08296336
64MP0010368_abnormal_lymphatic_system1.08169854
65MP0005220_abnormal_exocrine_pancreas1.06272647
66MP0004185_abnormal_adipocyte_glucose1.06259763
67MP0005408_hypopigmentation1.04929007
68MP0002971_abnormal_brown_adipose1.03870817
69MP0001958_emphysema1.03307645
70MP0010630_abnormal_cardiac_muscle1.02539002
71MP0005023_abnormal_wound_healing1.02034570
72MP0010352_gastrointestinal_tract_polyps1.01678986
73MP0000762_abnormal_tongue_morphology1.01278448
74MP0005248_abnormal_Harderian_gland1.00102906
75MP0005319_abnormal_enzyme/_coenzyme0.99415723
76MP0010771_integument_phenotype0.98840899
77MP0000377_abnormal_hair_follicle0.98524459
78MP0003300_gastrointestinal_ulcer0.98370696
79MP0000427_abnormal_hair_cycle0.97262148
80MP0005076_abnormal_cell_differentiation0.95261162
81MP0005451_abnormal_body_composition0.94830075
82MP0000647_abnormal_sebaceous_gland0.91426525
83MP0001661_extended_life_span0.90014612
84MP0002128_abnormal_blood_circulation0.86552306
85MP0005385_cardiovascular_system_phenoty0.85523333
86MP0001544_abnormal_cardiovascular_syste0.85523333
87MP0008775_abnormal_heart_ventricle0.85300044
88MP0002295_abnormal_pulmonary_circulatio0.85107113
89MP0009379_abnormal_foot_pigmentation0.85104804
90MP0001243_abnormal_dermal_layer0.84614596
91MP0000749_muscle_degeneration0.84573123
92MP0002896_abnormal_bone_mineralization0.84521152
93MP0002168_other_aberrant_phenotype0.82586003
94MP0001915_intracranial_hemorrhage0.82383342
95MP0002972_abnormal_cardiac_muscle0.82308898
96MP0001346_abnormal_lacrimal_gland0.81573467
97MP0009115_abnormal_fat_cell0.81229377
98MP0005595_abnormal_vascular_smooth0.81020642
99MP0005647_abnormal_sex_gland0.80516578
100MP0005620_abnormal_muscle_contractility0.80225327
101MP0000733_abnormal_muscle_development0.79906359
102MP0003385_abnormal_body_wall0.78254212
103MP0000428_abnormal_craniofacial_morphol0.78225567
104MP0001849_ear_inflammation0.78071884
105MP0005666_abnormal_adipose_tissue0.77825820
106MP0005165_increased_susceptibility_to0.77079098
107MP0003115_abnormal_respiratory_system0.77048393
108MP0004858_abnormal_nervous_system0.76937311
109MP0003011_delayed_dark_adaptation0.74946063
110MP0001614_abnormal_blood_vessel0.73695269
111MP0003828_pulmonary_edema0.73652501
112MP0009250_abnormal_appendicular_skeleto0.72488080
113MP0003890_abnormal_embryonic-extraembry0.71474815
114MP0006054_spinal_hemorrhage0.71099682
115MP0002925_abnormal_cardiovascular_devel0.70150437
116MP0005257_abnormal_intraocular_pressure0.70117605
117MP0000613_abnormal_salivary_gland0.69060247
118MP0000432_abnormal_head_morphology0.68954016
119MP0004130_abnormal_muscle_cell0.68926775
120MP0010030_abnormal_orbit_morphology0.68822579
121MP0005395_other_phenotype0.68738222
122MP0005369_muscle_phenotype0.68307123
123MP0001756_abnormal_urination0.68223824
124MP0000759_abnormal_skeletal_muscle0.66527897
125MP0003937_abnormal_limbs/digits/tail_de0.66451832
126MP0005508_abnormal_skeleton_morphology0.65838306
127MP0004381_abnormal_hair_follicle0.65800287
128MP0000538_abnormal_urinary_bladder0.65622380
129MP0002269_muscular_atrophy0.64911837
130MP0000266_abnormal_heart_morphology0.63264349
131MP0000534_abnormal_ureter_morphology0.62986079
132MP0005584_abnormal_enzyme/coenzyme_acti0.62929238
133MP0004782_abnormal_surfactant_physiolog0.62719881
134MP0000598_abnormal_liver_morphology0.62566914
135MP0003045_fibrosis0.62550166
136MP0003283_abnormal_digestive_organ0.62431195
137MP0009780_abnormal_chondrocyte_physiolo0.61912570
138MP0000627_abnormal_mammary_gland0.60663981
139MP0002697_abnormal_eye_size0.59062117
140MP0002108_abnormal_muscle_morphology0.57888727
141MP0005623_abnormal_meninges_morphology0.57288490
142MP0001340_abnormal_eyelid_morphology0.57067094
143MP0009931_abnormal_skin_appearance0.56898481
144MP0002282_abnormal_trachea_morphology0.56083584
145MP0001191_abnormal_skin_condition0.55968632
146MP0002111_abnormal_tail_morphology0.54252480
147MP0000163_abnormal_cartilage_morphology0.54242326
148MP0000516_abnormal_urinary_system0.53979626

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.79505414
2Deep venous thrombosis (HP:0002625)5.33601984
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.00102940
4Xanthomatosis (HP:0000991)4.80024664
5Hypobetalipoproteinemia (HP:0003563)4.45569205
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.43341422
7Aortic aneurysm (HP:0004942)4.40008254
8Prolonged partial thromboplastin time (HP:0003645)3.97957566
9Complement deficiency (HP:0004431)3.68764870
10Abnormality of glutamine family amino acid metabolism (HP:0010902)3.67701487
11Epidermoid cyst (HP:0200040)3.55151653
12Vascular tortuosity (HP:0004948)3.52765954
13Hypolipoproteinemia (HP:0010981)3.49153579
14Right ventricular cardiomyopathy (HP:0011663)3.39027795
15Fat malabsorption (HP:0002630)3.36205320
16Arterial tortuosity (HP:0005116)3.27727233
17Hyperlipoproteinemia (HP:0010980)3.23116749
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.12646033
19Hypoalphalipoproteinemia (HP:0003233)3.07506771
20Atrophic scars (HP:0001075)3.07082408
21Hyperglycinuria (HP:0003108)3.05399752
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.05292409
23Malnutrition (HP:0004395)3.02045375
24Hyperammonemia (HP:0001987)3.01192027
25Abnormality of the common coagulation pathway (HP:0010990)3.00032353
26Abnormality of glycine metabolism (HP:0010895)2.99089230
27Abnormality of serine family amino acid metabolism (HP:0010894)2.99089230
28Abnormality of aspartate family amino acid metabolism (HP:0010899)2.88788519
29Hyperglycinemia (HP:0002154)2.87813515
30Abnormality of the intrinsic pathway (HP:0010989)2.76967861
31Cardiovascular calcification (HP:0011915)2.75662729
32Cerebral aneurysm (HP:0004944)2.75305862
33Protrusio acetabuli (HP:0003179)2.74119926
34Conjugated hyperbilirubinemia (HP:0002908)2.73947945
35Abnormality of complement system (HP:0005339)2.72407639
36Soft skin (HP:0000977)2.68426358
37Hypoglycemic coma (HP:0001325)2.65668686
38Ketosis (HP:0001946)2.64945528
39Mildly elevated creatine phosphokinase (HP:0008180)2.64635906
40Vascular calcification (HP:0004934)2.64569155
41Premature rupture of membranes (HP:0001788)2.63616165
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.62254610
43Osteolytic defects of the hand bones (HP:0009699)2.62254610
44Neonatal short-limb short stature (HP:0008921)2.59521527
45Abnormality of carpal bone ossification (HP:0006257)2.56449027
46Alopecia of scalp (HP:0002293)2.55733740
47Wormian bones (HP:0002645)2.55505461
48Joint hemorrhage (HP:0005261)2.53516221
49Cervical subluxation (HP:0003308)2.51545271
50Focal segmental glomerulosclerosis (HP:0000097)2.51174234
51Skin nodule (HP:0200036)2.48451552
52Type 1 muscle fiber predominance (HP:0003803)2.46598049
53Aneurysm (HP:0002617)2.46267796
54Myocardial infarction (HP:0001658)2.44848901
55Abnormality of methionine metabolism (HP:0010901)2.44815357
56Spinal rigidity (HP:0003306)2.41169774
57Bladder diverticulum (HP:0000015)2.40998709
58Hepatocellular carcinoma (HP:0001402)2.39718093
59Esophageal varix (HP:0002040)2.39437629
60Hypercholesterolemia (HP:0003124)2.38363692
61Glomerulosclerosis (HP:0000096)2.36882454
62Abnormality of purine metabolism (HP:0004352)2.31274658
63Ventricular tachycardia (HP:0004756)2.31087732
64Milia (HP:0001056)2.25157313
65Gout (HP:0001997)2.25026366
66Overgrowth (HP:0001548)2.25017039
67Steatorrhea (HP:0002570)2.24136181
68Hyperactive renin-angiotensin system (HP:0000841)2.22449540
69Ileus (HP:0002595)2.21376346
70Spastic diplegia (HP:0001264)2.20707070
71Abnormality of the acetabulum (HP:0003170)2.19405978
72Rickets (HP:0002748)2.18995909
73Ankle contracture (HP:0006466)2.18585785
74Abnormal ossification of hand bones (HP:0005921)2.18502796
75Onycholysis (HP:0001806)2.18060398
76Abnormality of nucleobase metabolism (HP:0010932)2.16063485
77Turricephaly (HP:0000262)2.15724463
78Dilatation of the ascending aorta (HP:0005111)2.13572662
79Hydroxyprolinuria (HP:0003080)2.13555137
80Abnormality of proline metabolism (HP:0010907)2.13555137
81Coronal craniosynostosis (HP:0004440)2.12158976
82Ketoacidosis (HP:0001993)2.10553244
83Abnormal hand bone ossification (HP:0010660)2.08144680
84Abnormal cartilage morphology (HP:0002763)2.07385883
85Increased variability in muscle fiber diameter (HP:0003557)2.07176908
86Back pain (HP:0003418)2.07082753
87Peritonitis (HP:0002586)2.06960393
88Broad metatarsal (HP:0001783)2.06831210
89Fragile skin (HP:0001030)2.03924404
90Systemic lupus erythematosus (HP:0002725)2.03245064
91Delayed CNS myelination (HP:0002188)2.02322841
92Advanced eruption of teeth (HP:0006288)1.99915049
93Blue sclerae (HP:0000592)1.99892047
94Hemorrhage of the eye (HP:0011885)1.99670669
95Flat acetabular roof (HP:0003180)1.99540291
96Plantar hyperkeratosis (HP:0007556)1.99247180
97Vertebral compression fractures (HP:0002953)1.97265677
98Abnormal delivery (HP:0001787)1.97208421
99Fragile nails (HP:0001808)1.94030092
100Hypophosphatemic rickets (HP:0004912)1.92443040
101Acanthocytosis (HP:0001927)1.90043052
102Follicular hyperkeratosis (HP:0007502)1.89538375
103Protuberant abdomen (HP:0001538)1.88410028
104Abnormal hemoglobin (HP:0011902)1.88371269
105Striae distensae (HP:0001065)1.86517905
106Abnormality of pyrimidine metabolism (HP:0004353)1.85641141
107Nephritis (HP:0000123)1.85150856
108Wide anterior fontanel (HP:0000260)1.83248779
109Lipoatrophy (HP:0100578)1.82926822
110Shallow orbits (HP:0000586)1.81969291
111Hyperextensible skin (HP:0000974)1.81964150
112Hyperbilirubinemia (HP:0002904)1.81873711
113Abdominal distention (HP:0003270)1.81584263
114Bronchomalacia (HP:0002780)1.78864789
115Bundle branch block (HP:0011710)1.78645003
116Increased connective tissue (HP:0009025)1.78418501
117Joint laxity (HP:0001388)1.78322052
118Glomerulonephritis (HP:0000099)1.78167403
119Mitral valve prolapse (HP:0001634)1.78131184
120Abnormality of fatty-acid metabolism (HP:0004359)1.77478484
121Natal tooth (HP:0000695)1.77397509
122Coxa vara (HP:0002812)1.77394387
123Abnormality of the Achilles tendon (HP:0005109)1.76314520
124Rectal prolapse (HP:0002035)1.75853315
125Cupped ribs (HP:0000887)1.74405764
126Limited hip movement (HP:0008800)1.74196451
127Abnormality of skeletal muscle fiber size (HP:0012084)1.73780585
128Acanthosis nigricans (HP:0000956)1.73259544
129Aortic dissection (HP:0002647)1.72747238
130Lymphangioma (HP:0100764)1.72523713
131Hyporeflexia of lower limbs (HP:0002600)1.72292715
132Hyperkalemia (HP:0002153)1.70162287
133Hyperglycemia (HP:0003074)1.69591782
134Short nail (HP:0001799)1.69439306
135Mitral stenosis (HP:0001718)1.67579568
136Potter facies (HP:0002009)1.67513265
137Facial shape deformation (HP:0011334)1.67513265
138Wrist flexion contracture (HP:0001239)1.66845339
139Hypotrichosis (HP:0001006)1.65611859
140Sudden death (HP:0001699)1.65316864
141Abnormality of dentin (HP:0010299)1.63571999
142Increased mean platelet volume (HP:0011877)1.63239535
143Spontaneous abortion (HP:0005268)1.63028531
144Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.62969659
145Parakeratosis (HP:0001036)1.62057781
146Hypoglycemic seizures (HP:0002173)1.60075877
147Corneal erosion (HP:0200020)1.58672910
148Muscle fiber splitting (HP:0003555)1.57943889
149Late onset (HP:0003584)1.57168276
150Asymmetry of the thorax (HP:0001555)1.56729862
151Thin bony cortex (HP:0002753)1.55996221
152Abnormal tarsal ossification (HP:0008369)1.55694596
153Abnormality of the distal phalanx of the thumb (HP:0009617)1.54399068
154Aortic regurgitation (HP:0001659)1.53999942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.03707789
2EPHA23.80685134
3MST1R3.30710719
4SIK12.84327119
5ERN12.76421426
6FRK2.66020602
7MET2.61980435
8EPHB22.17106266
9DDR22.14546395
10ERBB42.13292937
11EEF2K2.12230194
12PTK62.06855997
13MST42.06600650
14FGFR42.05342094
15FER2.04326857
16EPHB11.95012620
17BCKDK1.94867601
18FGFR21.94188748
19PDGFRA1.92050778
20TIE11.82319766
21TRIB31.74831651
22STK241.71257377
23RIPK11.65222542
24PTK21.60531529
25LATS21.59710036
26STK38L1.55299405
27MAP3K21.50457209
28STK391.48839091
29TTN1.45447905
30MAP2K21.38624826
31ACVR1B1.36903663
32PKN21.36113512
33ICK1.28985688
34MAP3K31.28041771
35STK31.24273712
36LMTK21.19838322
37WNK41.19680091
38CDK121.18502414
39BMX1.13930182
40INSRR1.12791382
41CAMK1D1.11153935
42CDK61.09856973
43CDC42BPA1.08435325
44ERBB21.07607478
45PDGFRB1.05952887
46PAK21.05234781
47TAOK31.04535199
48MAPK151.04282484
49PAK31.04237480
50NLK1.02871119
51NUAK11.02324721
52EPHA31.01686472
53GSK3A1.01221639
54MTOR1.01040534
55TYRO30.97137446
56LRRK20.95210769
57OBSCN0.94244222
58STK380.90777050
59OXSR10.90719813
60FGFR10.88313290
61TRPM70.87721690
62MAP3K60.86257862
63MAPKAPK30.85953818
64RPS6KB20.83949915
65BRSK20.83519529
66PIK3CG0.82047605
67TGFBR20.81874195
68STK100.76594420
69PAK40.75019278
70MAP3K70.74759940
71AKT30.73871580
72PRKAA20.73547024
73MELK0.72335884
74DYRK1B0.71520477
75MAP2K10.71087656
76BCR0.70501191
77PIK3CA0.69743729
78NTRK10.68919128
79ROCK10.67775839
80MAPK110.66402448
81RET0.66038361
82PBK0.65262298
83NEK90.60464993
84DMPK0.59653080
85CAMK1G0.57244819
86MAP3K10.56119651
87FGFR30.52127947
88SGK30.51714639
89ABL20.51474091
90PRKD10.51232764
91PRKG20.48108852
92TTK0.48090566
93MAP3K100.47416827
94PRKCE0.45309555
95PDK20.45049186
96FLT30.44829240
97CSNK1G10.44025583
98SGK20.43090556
99MAP3K120.42907127
100CAMK2D0.38932923
101PRKAA10.38666591
102RPS6KA20.38485021
103INSR0.38312243
104SCYL20.37541157
105PRKCI0.37089714
106SGK2230.37019802
107SGK4940.37019802
108WNK10.36610442
109TGFBR10.36469962
110CSNK1A1L0.35708872
111TESK10.35503518
112MYLK0.35477998
113IGF1R0.32804960
114PDPK10.32762996
115PNCK0.32716985
116SMG10.31551005
117MAPK70.30699030
118ROCK20.30626033
119SRC0.29777357
120PRKCZ0.29699559
121EGFR0.29529108
122CSK0.28864769
123ABL10.28343863
124MAP2K40.28049387
125MAPK10.27703777
126LIMK10.27679314
127PRKACG0.26534607
128CAMK2G0.25793832
129CSNK1D0.25742921

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.52888309
2Nitrogen metabolism_Homo sapiens_hsa009103.42352148
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14564031
4Arginine biosynthesis_Homo sapiens_hsa002202.52021830
5Fatty acid degradation_Homo sapiens_hsa000712.41653742
6Tryptophan metabolism_Homo sapiens_hsa003802.40259131
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31016699
8Complement and coagulation cascades_Homo sapiens_hsa046102.26896702
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.25253345
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.24646516
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14424402
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09881126
13Histidine metabolism_Homo sapiens_hsa003402.07341706
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.07004988
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02858491
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.02658851
17Chemical carcinogenesis_Homo sapiens_hsa052041.96633723
18Sulfur metabolism_Homo sapiens_hsa009201.96210021
19PPAR signaling pathway_Homo sapiens_hsa033201.88098504
20Butanoate metabolism_Homo sapiens_hsa006501.87243315
21Fatty acid metabolism_Homo sapiens_hsa012121.84845812
22Caffeine metabolism_Homo sapiens_hsa002321.83473923
23Fat digestion and absorption_Homo sapiens_hsa049751.74784799
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.72067491
25Retinol metabolism_Homo sapiens_hsa008301.67130747
26Peroxisome_Homo sapiens_hsa041461.66593440
27Propanoate metabolism_Homo sapiens_hsa006401.66221011
28Bile secretion_Homo sapiens_hsa049761.63271829
29Steroid biosynthesis_Homo sapiens_hsa001001.54372374
30beta-Alanine metabolism_Homo sapiens_hsa004101.48965079
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40427816
32Vitamin digestion and absorption_Homo sapiens_hsa049771.40266475
33Phenylalanine metabolism_Homo sapiens_hsa003601.39578783
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.39245769
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38338621
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36579724
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36272597
38Selenocompound metabolism_Homo sapiens_hsa004501.34760223
39Starch and sucrose metabolism_Homo sapiens_hsa005001.34740160
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.31706820
41Fatty acid elongation_Homo sapiens_hsa000621.30088568
42Dilated cardiomyopathy_Homo sapiens_hsa054141.29077535
43Tyrosine metabolism_Homo sapiens_hsa003501.23751133
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16061837
45ECM-receptor interaction_Homo sapiens_hsa045121.14936194
46Pyruvate metabolism_Homo sapiens_hsa006201.14760699
47ABC transporters_Homo sapiens_hsa020101.13604348
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.11658364
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08522760
50Fatty acid biosynthesis_Homo sapiens_hsa000611.08008702
51Folate biosynthesis_Homo sapiens_hsa007901.07760704
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04441362
53Glutathione metabolism_Homo sapiens_hsa004801.03630402
54Lysine degradation_Homo sapiens_hsa003101.03094445
55Staphylococcus aureus infection_Homo sapiens_hsa051500.98292264
56Arginine and proline metabolism_Homo sapiens_hsa003300.97937463
57Protein digestion and absorption_Homo sapiens_hsa049740.94058987
58Carbon metabolism_Homo sapiens_hsa012000.83386412
59Biosynthesis of amino acids_Homo sapiens_hsa012300.80284618
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.77542985
61Glucagon signaling pathway_Homo sapiens_hsa049220.75479695
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74097206
63Glycerolipid metabolism_Homo sapiens_hsa005610.73452880
64Circadian rhythm_Homo sapiens_hsa047100.72916373
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72017510
66Mineral absorption_Homo sapiens_hsa049780.71250137
67Adherens junction_Homo sapiens_hsa045200.66583687
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64222492
69Fructose and mannose metabolism_Homo sapiens_hsa000510.64111816
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.63753555
71Bladder cancer_Homo sapiens_hsa052190.62460462
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61783052
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61742802
74Renin secretion_Homo sapiens_hsa049240.61272467
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60855499
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60236514
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59945670
78Thyroid hormone synthesis_Homo sapiens_hsa049180.58980651
79Tight junction_Homo sapiens_hsa045300.56939218
80Thyroid cancer_Homo sapiens_hsa052160.53875626
81Amoebiasis_Homo sapiens_hsa051460.53466472
82Basal cell carcinoma_Homo sapiens_hsa052170.53207884
83Pancreatic secretion_Homo sapiens_hsa049720.52365865
84Insulin signaling pathway_Homo sapiens_hsa049100.51312354
85Linoleic acid metabolism_Homo sapiens_hsa005910.50893990
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49098457
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.48957905
88MicroRNAs in cancer_Homo sapiens_hsa052060.48863809
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48775973
90Focal adhesion_Homo sapiens_hsa045100.48370529
91Renin-angiotensin system_Homo sapiens_hsa046140.48282039
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.46695021
93Hippo signaling pathway_Homo sapiens_hsa043900.45106723
94Vitamin B6 metabolism_Homo sapiens_hsa007500.43277479
95Sulfur relay system_Homo sapiens_hsa041220.42995912
96Insulin resistance_Homo sapiens_hsa049310.42872793
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42632766
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40758452
99Wnt signaling pathway_Homo sapiens_hsa043100.39641890
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39601082
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38836065
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37854786
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37409586
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.36999134
105Proteoglycans in cancer_Homo sapiens_hsa052050.36139024
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35779030
107Small cell lung cancer_Homo sapiens_hsa052220.35730965
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32925289
109Prion diseases_Homo sapiens_hsa050200.32354040
110Hedgehog signaling pathway_Homo sapiens_hsa043400.31378766
111One carbon pool by folate_Homo sapiens_hsa006700.30822740
112Galactose metabolism_Homo sapiens_hsa000520.30061289
113TGF-beta signaling pathway_Homo sapiens_hsa043500.29639862
114AMPK signaling pathway_Homo sapiens_hsa041520.27858135
115Metabolic pathways_Homo sapiens_hsa011000.26958696
116Pentose phosphate pathway_Homo sapiens_hsa000300.25628627
117Sphingolipid metabolism_Homo sapiens_hsa006000.20862118
118Ovarian steroidogenesis_Homo sapiens_hsa049130.15383163
119Ether lipid metabolism_Homo sapiens_hsa005650.14684311
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14515769
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14212304
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14209359
123Arachidonic acid metabolism_Homo sapiens_hsa005900.14087156
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13260578

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »