SH3GL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1planar cell polarity pathway involved in neural tube closure (GO:0090179)4.52858229
2hemidesmosome assembly (GO:0031581)4.23824081
3protein localization to endosome (GO:0036010)4.22371351
4regulation of early endosome to late endosome transport (GO:2000641)4.11286008
5regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.11017658
6skin morphogenesis (GO:0043589)4.05069916
7protein retention in ER lumen (GO:0006621)4.03042339
8basement membrane organization (GO:0071711)3.95863844
9ribosomal small subunit assembly (GO:0000028)3.88013665
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.87601739
11cell-substrate junction assembly (GO:0007044)3.81560120
12adherens junction assembly (GO:0034333)3.78509463
13desmosome organization (GO:0002934)3.74660913
14endodermal cell differentiation (GO:0035987)3.67894409
15DNA deamination (GO:0045006)3.54698981
16protein heterotrimerization (GO:0070208)3.52103004
17DNA strand elongation involved in DNA replication (GO:0006271)3.48961627
18focal adhesion assembly (GO:0048041)3.42808922
19cell-substrate adherens junction assembly (GO:0007045)3.42808922
20DNA unwinding involved in DNA replication (GO:0006268)3.41627383
21formation of translation preinitiation complex (GO:0001731)3.41033739
22semaphorin-plexin signaling pathway (GO:0071526)3.34455561
23adhesion of symbiont to host (GO:0044406)3.33649525
24viral transcription (GO:0019083)3.32970007
25DNA strand elongation (GO:0022616)3.30114696
26regulation of mammary gland epithelial cell proliferation (GO:0033599)3.26864404
27virion attachment to host cell (GO:0019062)3.24388112
28adhesion of symbiont to host cell (GO:0044650)3.24388112
29proline biosynthetic process (GO:0006561)3.24346749
30translational termination (GO:0006415)3.23558531
31vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.22991470
32epithelial cell-cell adhesion (GO:0090136)3.22344740
33regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.21562236
34regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.20897807
35positive regulation of blood vessel endothelial cell migration (GO:0043536)3.16212225
36maturation of SSU-rRNA (GO:0030490)3.16094553
37telomere maintenance via semi-conservative replication (GO:0032201)3.15802277
38regulation of apoptotic process involved in morphogenesis (GO:1902337)3.12378417
39DNA replication initiation (GO:0006270)3.11731503
40stress fiber assembly (GO:0043149)3.11300211
41regulation of extracellular matrix disassembly (GO:0010715)3.09403904
42Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.08940054
43cytoskeletal anchoring at plasma membrane (GO:0007016)3.08418047
44protein localization to kinetochore (GO:0034501)3.05009487
45negative regulation of cell size (GO:0045792)3.04103603
46apoptotic process involved in morphogenesis (GO:0060561)3.03931823
47vascular endothelial growth factor signaling pathway (GO:0038084)3.03141034
48translational elongation (GO:0006414)3.01078346
49dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.99771834
50endothelial cell morphogenesis (GO:0001886)2.96525243
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.95420321
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.95420321
53negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.94081557
54cell-cell junction maintenance (GO:0045217)2.93753678
55tooth mineralization (GO:0034505)2.93717686
56negative regulation of catenin import into nucleus (GO:0035414)2.93709887
57endothelial cell chemotaxis (GO:0035767)2.92789993
58atrioventricular valve morphogenesis (GO:0003181)2.91398404
59cell migration involved in heart development (GO:0060973)2.90489994
60ribosomal small subunit biogenesis (GO:0042274)2.90430549
61regulation of establishment of planar polarity (GO:0090175)2.89729193
62protein maturation by protein folding (GO:0022417)2.89355369
63SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87932665
64translational initiation (GO:0006413)2.87740222
65positive regulation of gamma-delta T cell activation (GO:0046645)2.87633141
66COPI coating of Golgi vesicle (GO:0048205)2.87050633
67Golgi transport vesicle coating (GO:0048200)2.87050633
68folic acid-containing compound biosynthetic process (GO:0009396)2.86731924
69mitotic nuclear envelope disassembly (GO:0007077)2.85719910
70pinocytosis (GO:0006907)2.83285937
71negative regulation of fatty acid transport (GO:2000192)2.82355437
72NIK/NF-kappaB signaling (GO:0038061)2.80731024
73protein targeting to ER (GO:0045047)2.80568918
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.79245300
75telomere maintenance via recombination (GO:0000722)2.79024013
76cochlea morphogenesis (GO:0090103)2.78400719
77mannose metabolic process (GO:0006013)2.76456600
78cotranslational protein targeting to membrane (GO:0006613)2.75555948
79membrane tubulation (GO:0097320)2.74969012
80Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73010186
81antigen processing and presentation via MHC class Ib (GO:0002475)2.71535984
82peptidyl-proline hydroxylation (GO:0019511)2.71441543
83protein localization to chromosome, centromeric region (GO:0071459)2.70363205
84endothelial tube morphogenesis (GO:0061154)2.69150282
85morphogenesis of an endothelium (GO:0003159)2.69150282
86cell adhesion mediated by integrin (GO:0033627)2.69079593
87venous blood vessel morphogenesis (GO:0048845)2.69071442
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.67177071
89nucleobase biosynthetic process (GO:0046112)2.66822048
90collagen metabolic process (GO:0032963)2.66231392
91viral life cycle (GO:0019058)2.65815916
92T cell apoptotic process (GO:0070231)2.65599177
93chondrocyte proliferation (GO:0035988)2.65558174
94establishment of protein localization to endoplasmic reticulum (GO:0072599)2.65053770
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.64396603
96collagen fibril organization (GO:0030199)2.63882127
97regulation of protein heterodimerization activity (GO:0043497)2.62347778
98nuclear envelope disassembly (GO:0051081)2.62180951
99membrane disassembly (GO:0030397)2.62180951
100UV protection (GO:0009650)2.61859931
101convergent extension (GO:0060026)2.61521753
102protein localization to endoplasmic reticulum (GO:0070972)2.61118551
103activation of Rac GTPase activity (GO:0032863)2.60353123
104positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.60125140
105hyaluronan catabolic process (GO:0030214)2.59781848
106negative regulation of chondrocyte differentiation (GO:0032331)2.58151695
107antigen processing and presentation of endogenous antigen (GO:0019883)2.58004206
108muscle cell migration (GO:0014812)2.57008745
109DNA replication-dependent nucleosome assembly (GO:0006335)2.56863376
110DNA replication-dependent nucleosome organization (GO:0034723)2.56863376
111mitotic recombination (GO:0006312)2.56666733
112blood vessel endothelial cell migration (GO:0043534)2.55899513
113maternal placenta development (GO:0001893)2.55768540
114endocytic recycling (GO:0032456)2.55372502
115extracellular matrix disassembly (GO:0022617)2.54667712
116activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.54488732
117embryo implantation (GO:0007566)2.53426267
118apoptotic cell clearance (GO:0043277)2.52236906
119positive regulation of receptor recycling (GO:0001921)2.52001864
120telomere maintenance via telomere lengthening (GO:0010833)2.51189459
121collagen catabolic process (GO:0030574)2.51053874
122regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.49921888
123multicellular organismal macromolecule metabolic process (GO:0044259)2.49549526
124cellular protein complex disassembly (GO:0043624)2.49284872
125positive regulation of protein dephosphorylation (GO:0035307)2.48754491
126regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.47384857
127low-density lipoprotein particle clearance (GO:0034383)2.47162491
128IMP biosynthetic process (GO:0006188)2.47083777
129cell junction maintenance (GO:0034331)2.46689197
130DNA replication checkpoint (GO:0000076)2.46449217
131cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.46147731
132negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.45126866
133actin filament bundle organization (GO:0061572)2.45116773
134actin filament bundle assembly (GO:0051017)2.45116773
135decidualization (GO:0046697)2.43190563
136purine nucleobase biosynthetic process (GO:0009113)2.42309989
137positive regulation of nuclease activity (GO:0032075)2.41734687
138negative regulation of focal adhesion assembly (GO:0051895)2.40397209
139negative regulation of cell junction assembly (GO:1901889)2.40397209
140negative regulation of adherens junction organization (GO:1903392)2.40397209
141heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.39578061
142regulation of gamma-delta T cell differentiation (GO:0045586)2.39126806
143negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.38596875
144lymphocyte apoptotic process (GO:0070227)2.37388463
145pentose-phosphate shunt (GO:0006098)2.35877075
146bone trabecula formation (GO:0060346)2.35860462
147protein complex disassembly (GO:0043241)2.35243731
148ribonucleoprotein complex biogenesis (GO:0022613)2.34571704
149nucleotide-excision repair, DNA gap filling (GO:0006297)2.34534240
150modulation by virus of host morphology or physiology (GO:0019048)2.34193775
151deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.34151579
152regulation of gene silencing by RNA (GO:0060966)2.34078588
153regulation of posttranscriptional gene silencing (GO:0060147)2.34078588
154regulation of gene silencing by miRNA (GO:0060964)2.34078588
155ribosome biogenesis (GO:0042254)2.32466682
156negative regulation of RNA splicing (GO:0033119)2.30076383
157regulation of type I interferon-mediated signaling pathway (GO:0060338)2.30071532
158B cell mediated immunity (GO:0019724)2.29642641
159regulation of spindle organization (GO:0090224)2.26274765
160nuclear-transcribed mRNA catabolic process (GO:0000956)2.26145674
161negative regulation of interleukin-12 production (GO:0032695)2.25480681
162immunoglobulin mediated immune response (GO:0016064)2.25062024
1633-UTR-mediated mRNA stabilization (GO:0070935)2.24997947
164mitotic G1 DNA damage checkpoint (GO:0031571)2.22010167
165mitotic metaphase plate congression (GO:0007080)2.20846706
166dosage compensation (GO:0007549)2.20486776
167nuclear envelope organization (GO:0006998)2.19432549
168regulation of gamma-delta T cell activation (GO:0046643)2.19007053
169barbed-end actin filament capping (GO:0051016)2.18833925
170heterochromatin organization (GO:0070828)2.18145004
171base-excision repair (GO:0006284)2.17348559
172IMP metabolic process (GO:0046040)2.16515690
173regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.15755963
174mitotic chromosome condensation (GO:0007076)2.15549856
175mRNA catabolic process (GO:0006402)2.15517441
176macromolecular complex disassembly (GO:0032984)2.15488087
177RNA catabolic process (GO:0006401)2.15409272
178mitotic G1/S transition checkpoint (GO:0044819)2.15121006
179DNA duplex unwinding (GO:0032508)2.14839521
180regulation of translational fidelity (GO:0006450)2.12161238
181positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.12078747
182negative regulation of erythrocyte differentiation (GO:0045647)2.11795909
183DNA geometric change (GO:0032392)2.11438382
184termination of RNA polymerase II transcription (GO:0006369)2.07315539
185histone-serine phosphorylation (GO:0035404)2.06869039
186sequestering of actin monomers (GO:0042989)2.05814306
187ribosomal large subunit biogenesis (GO:0042273)2.05704228
188translesion synthesis (GO:0019985)2.05545713
189rRNA processing (GO:0006364)2.05416257
190negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.05200649
191purine-containing compound salvage (GO:0043101)2.04785565
192telomere organization (GO:0032200)2.03832526
193anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.03669146
194response to laminar fluid shear stress (GO:0034616)2.03476331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.39435085
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35497595
3MYC_18555785_ChIP-Seq_MESCs_Mouse2.93334880
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.88598266
5MYC_22102868_ChIP-Seq_BL_Human2.65106115
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.61565959
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.61560866
8RACK7_27058665_Chip-Seq_MCF-7_Human2.30532791
9* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18232487
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16713840
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15040451
12VDR_21846776_ChIP-Seq_THP-1_Human2.04899206
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04352007
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03524825
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02828544
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99888819
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98012578
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.95008940
19XRN2_22483619_ChIP-Seq_HELA_Human1.89549019
20MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89277935
21ZNF263_19887448_ChIP-Seq_K562_Human1.87754049
22UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.86000424
23KDM2B_26808549_Chip-Seq_K562_Human1.84614396
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84328879
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.83332379
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82441593
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80218484
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.79735855
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.79121990
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78616521
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78374192
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78354417
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78320385
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.77101646
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74671669
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72802488
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72605393
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68681898
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.68234842
40CLOCK_20551151_ChIP-Seq_293T_Human1.67955634
41* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64952802
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.62780418
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.61604898
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61339543
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.60949060
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60010550
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59605538
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59260942
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.58584934
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.57825958
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.57422921
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57166691
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56394513
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55290435
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53059412
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52965624
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51948339
58* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51566307
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50469896
60TP53_22127205_ChIP-Seq_IMR90_Human1.50411336
61MAF_26560356_Chip-Seq_TH1_Human1.50024922
62* ATF3_27146783_Chip-Seq_COLON_Human1.49729421
63* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49664591
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49322498
65CIITA_25753668_ChIP-Seq_RAJI_Human1.47508583
66* P68_20966046_ChIP-Seq_HELA_Human1.47290261
67GABP_19822575_ChIP-Seq_HepG2_Human1.47190180
68VDR_23849224_ChIP-Seq_CD4+_Human1.47144628
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46476185
70* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43037905
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41740913
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41322548
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40392329
74UTX_26944678_Chip-Seq_JUKART_Human1.40366908
75SPI1_23547873_ChIP-Seq_NB4_Human1.40162559
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39924690
77TFEB_21752829_ChIP-Seq_HELA_Human1.37640682
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37414271
79DCP1A_22483619_ChIP-Seq_HELA_Human1.36331725
80FOXP3_21729870_ChIP-Seq_TREG_Human1.33580012
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33059396
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31685883
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31468533
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.31053762
85SMC4_20622854_ChIP-Seq_HELA_Human1.30843741
86TCF7_22412390_ChIP-Seq_EML_Mouse1.30637237
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30198642
88* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29654428
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.29004684
90CREB1_26743006_Chip-Seq_LNCaP_Human1.28583638
91* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25244136
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.24845338
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.24786972
94SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24774791
95AR_21909140_ChIP-Seq_LNCAP_Human1.24601849
96KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24192892
97* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23955461
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23831888
99MYB_26560356_Chip-Seq_TH2_Human1.23740009
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.23663694
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23130950
102SCL_19346495_ChIP-Seq_HPC-7_Human1.23090739
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23077885
104IRF8_21731497_ChIP-ChIP_J774_Mouse1.22815243
105CTCF_27219007_Chip-Seq_Bcells_Human1.21716072
106ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21337557
107MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21057703
108FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20710037
109HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19999371
110TTF2_22483619_ChIP-Seq_HELA_Human1.19655820
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19514663
112* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19086502
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19064115
114VDR_24763502_ChIP-Seq_THP-1_Human1.18796149
115CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18726373
116STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18522057
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18275011
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17845611
119RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17798495
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17462446
121ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17344509
122P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16878080
123MYB_26560356_Chip-Seq_TH1_Human1.16068037
124BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16030701
125MAF_26560356_Chip-Seq_TH2_Human1.15219682
126STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14596713
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14308998
128NCOR1_26117541_ChIP-Seq_K562_Human1.13688190
129SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12723164
130SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09961389
131ELF1_20517297_ChIP-Seq_JURKAT_Human1.09931094
132* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08525349
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08075223
134KDM5A_27292631_Chip-Seq_BREAST_Human1.07713856
135HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07572075
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07512308
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07383063
138* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06738263
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06120278
140* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05639140
141E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05101338
142MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04334032
143* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04281598
144* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03695765
145* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03130841
146* TP63_22573176_ChIP-Seq_HFKS_Human1.02391922
147SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02160881
148KDM2B_26808549_Chip-Seq_DND41_Human1.02091328
149CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01698254
150TP53_20018659_ChIP-ChIP_R1E_Mouse1.01558722
151CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00998279
152RARA_24833708_ChIP-Seq_LIVER_Mouse1.00881406
153CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00840180
154LXR_22292898_ChIP-Seq_THP-1_Human1.00747888
155TET1_21490601_ChIP-Seq_MESCs_Mouse1.00616001
156MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99957297
157KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98843043
158* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98106609
159CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97852689
160* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97741559
161SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97533561
162THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97481190
163BCOR_27268052_Chip-Seq_Bcells_Human0.96638698
164SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95205257
165MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95118799
166STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93028348
167* RARB_24833708_ChIP-Seq_LIVER_Mouse0.92596810
168JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91307429
169OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90771853
170SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90540568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system2.92801867
2MP0003693_abnormal_embryo_hatching2.87949975
3MP0008438_abnormal_cutaneous_collagen2.85843170
4MP0005257_abnormal_intraocular_pressure2.70055159
5MP0006054_spinal_hemorrhage2.50213551
6MP0005623_abnormal_meninges_morphology2.34075335
7MP0005058_abnormal_lysosome_morphology2.32309017
8MP0010352_gastrointestinal_tract_polyps2.27989274
9MP0003111_abnormal_nucleus_morphology2.23404246
10MP0004957_abnormal_blastocyst_morpholog2.22896530
11MP0003705_abnormal_hypodermis_morpholog2.17548827
12MP0002396_abnormal_hematopoietic_system2.16864188
13MP0003077_abnormal_cell_cycle2.14544346
14MP0008007_abnormal_cellular_replicative2.07826316
15MP0003763_abnormal_thymus_physiology2.04720509
16MP0000685_abnormal_immune_system2.03388133
17MP0003279_aneurysm2.03046627
18MP0002796_impaired_skin_barrier2.02234356
19MP0009333_abnormal_splenocyte_physiolog2.00593391
20MP0010094_abnormal_chromosome_stability1.98076690
21MP0008260_abnormal_autophagy1.96229740
22MP0000678_abnormal_parathyroid_gland1.92442020
23MP0005409_darkened_coat_color1.88129048
24MP0010234_abnormal_vibrissa_follicle1.85420308
25MP0003453_abnormal_keratinocyte_physiol1.85176276
26MP0009278_abnormal_bone_marrow1.84447533
27MP0004185_abnormal_adipocyte_glucose1.83839844
28MP0004808_abnormal_hematopoietic_stem1.82704952
29MP0009053_abnormal_anal_canal1.81522178
30MP0005023_abnormal_wound_healing1.80006217
31MP0004233_abnormal_muscle_weight1.71320798
32MP0003566_abnormal_cell_adhesion1.69725085
33MP0005275_abnormal_skin_tensile1.66023109
34MP0008057_abnormal_DNA_replication1.59664279
35MP0005501_abnormal_skin_physiology1.59650668
36MP0005397_hematopoietic_system_phenotyp1.58478231
37MP0001545_abnormal_hematopoietic_system1.58478231
38MP0001835_abnormal_antigen_presentation1.54714593
39MP0002398_abnormal_bone_marrow1.51737878
40MP0002249_abnormal_larynx_morphology1.45920154
41MP0000858_altered_metastatic_potential1.45762660
42MP0009384_cardiac_valve_regurgitation1.45667761
43MP0000490_abnormal_crypts_of1.44540473
44MP0003436_decreased_susceptibility_to1.44094744
45MP0001730_embryonic_growth_arrest1.43165566
46MP0000350_abnormal_cell_proliferation1.40664792
47MP0000003_abnormal_adipose_tissue1.39976225
48MP0000537_abnormal_urethra_morphology1.39826239
49MP0002722_abnormal_immune_system1.38049983
50MP0000579_abnormal_nail_morphology1.37603473
51MP0000703_abnormal_thymus_morphology1.37062380
52MP0000750_abnormal_muscle_regeneration1.36316775
53MP0001348_abnormal_lacrimal_gland1.35608177
54MP0005503_abnormal_tendon_morphology1.34253949
55MP0005671_abnormal_response_to1.33538984
56MP0002452_abnormal_antigen_presenting1.33094914
57MP0000689_abnormal_spleen_morphology1.33013772
58MP0002405_respiratory_system_inflammati1.32442113
59MP0002420_abnormal_adaptive_immunity1.30353624
60MP0000465_gastrointestinal_hemorrhage1.30101670
61MP0001243_abnormal_dermal_layer1.29692597
62MP0001800_abnormal_humoral_immune1.29577680
63MP0005451_abnormal_body_composition1.29451242
64MP0001819_abnormal_immune_cell1.29217719
65MP0000762_abnormal_tongue_morphology1.29004796
66MP0008058_abnormal_DNA_repair1.26331665
67MP0008932_abnormal_embryonic_tissue1.24914176
68MP0002254_reproductive_system_inflammat1.22256559
69MP0002896_abnormal_bone_mineralization1.22065832
70MP0002723_abnormal_immune_serum1.21264785
71MP0000467_abnormal_esophagus_morphology1.21186418
72MP0000716_abnormal_immune_system1.21125107
73MP0002429_abnormal_blood_cell1.21062492
74MP0004947_skin_inflammation1.20840835
75MP0009785_altered_susceptibility_to1.20555681
76MP0005000_abnormal_immune_tolerance1.20030825
77MP0004272_abnormal_basement_membrane1.19440099
78MP0002933_joint_inflammation1.18532521
79MP0002019_abnormal_tumor_incidence1.18058117
80MP0005076_abnormal_cell_differentiation1.16245662
81MP0005025_abnormal_response_to1.14186052
82MP0000534_abnormal_ureter_morphology1.14120748
83MP0010368_abnormal_lymphatic_system1.13534431
84MP0010307_abnormal_tumor_latency1.13032463
85MP0001915_intracranial_hemorrhage1.12996061
86MP0001216_abnormal_epidermal_layer1.11895148
87MP0001958_emphysema1.10292268
88MP0003172_abnormal_lysosome_physiology1.09306875
89MP0002080_prenatal_lethality1.08253362
90MP0003942_abnormal_urinary_system1.08085139
91MP0002419_abnormal_innate_immunity1.08056260
92MP0005375_adipose_tissue_phenotype1.07970123
93MP0001697_abnormal_embryo_size1.07671700
94MP0003191_abnormal_cellular_cholesterol1.07357401
95MP0001542_abnormal_bone_strength1.07301342
96MP0001533_abnormal_skeleton_physiology1.06576996
97MP0003123_paternal_imprinting1.05549490
98MP0005464_abnormal_platelet_physiology1.04590002
99MP0003448_altered_tumor_morphology1.04450169
100MP0005387_immune_system_phenotype1.04074342
101MP0001790_abnormal_immune_system1.04074342
102MP0002086_abnormal_extraembryonic_tissu1.03128651
103MP0010030_abnormal_orbit_morphology1.02329606
104MP0001672_abnormal_embryogenesis/_devel1.01593655
105MP0005380_embryogenesis_phenotype1.01593655
106MP0009840_abnormal_foam_cell1.01402716
107MP0003941_abnormal_skin_development1.00571323
108MP0002060_abnormal_skin_morphology1.00266009
109MP0000566_synostosis0.99993952
110MP0003984_embryonic_growth_retardation0.99520605
111MP0000313_abnormal_cell_death0.98128541
112MP0002088_abnormal_embryonic_growth/wei0.97947565
113MP0010155_abnormal_intestine_physiology0.97584027
114MP0000751_myopathy0.96808188
115MP0005595_abnormal_vascular_smooth0.96677714
116MP0009379_abnormal_foot_pigmentation0.96564143
117MP0003329_amyloid_beta_deposits0.96170445
118MP0004197_abnormal_fetal_growth/weight/0.96035097
119MP0002089_abnormal_postnatal_growth/wei0.95352246
120MP0003091_abnormal_cell_migration0.93958901
121MP0002166_altered_tumor_susceptibility0.93212441
122MP0003303_peritoneal_inflammation0.93174191
123MP0010771_integument_phenotype0.92819563
124MP0005390_skeleton_phenotype0.92104924
125MP0000013_abnormal_adipose_tissue0.91976988
126MP0009250_abnormal_appendicular_skeleto0.91672287
127MP0003300_gastrointestinal_ulcer0.90107089
128MP0002085_abnormal_embryonic_tissue0.90056307
129MP0005666_abnormal_adipose_tissue0.88796338
130MP0009931_abnormal_skin_appearance0.88015383
131MP0000767_abnormal_smooth_muscle0.87152372
132MP0000733_abnormal_muscle_development0.87043495
133MP0001873_stomach_inflammation0.86441607
134MP0000049_abnormal_middle_ear0.86195021
135MP0005197_abnormal_uvea_morphology0.86021284
136MP0005508_abnormal_skeleton_morphology0.85122696
137MP0001853_heart_inflammation0.85080897
138MP0003385_abnormal_body_wall0.83234698
139MP0002697_abnormal_eye_size0.82884502
140MP0005621_abnormal_cell_physiology0.82710399
141MP0002084_abnormal_developmental_patter0.82640335
142MP0002148_abnormal_hypersensitivity_rea0.81517636
143MP0002877_abnormal_melanocyte_morpholog0.81506598
144MP0000759_abnormal_skeletal_muscle0.81254575
145MP0002998_abnormal_bone_remodeling0.81211689
146MP0005360_urolithiasis0.81009445
147MP0002098_abnormal_vibrissa_morphology0.80595104
148MP0000477_abnormal_intestine_morphology0.79133475
149MP0001614_abnormal_blood_vessel0.78842187
150MP0003724_increased_susceptibility_to0.77745808
151MP0000462_abnormal_digestive_system0.77264712
152MP0001845_abnormal_inflammatory_respons0.75178381
153MP0001849_ear_inflammation0.74861930
154MP0003795_abnormal_bone_structure0.72933970
155MP0002113_abnormal_skeleton_development0.72657947
156MP0000428_abnormal_craniofacial_morphol0.71383353
157MP0009780_abnormal_chondrocyte_physiolo0.69861892
158MP0002932_abnormal_joint_morphology0.69237757
159MP0002925_abnormal_cardiovascular_devel0.68237212
160MP0005193_abnormal_anterior_eye0.67417424
161MP0005670_abnormal_white_adipose0.67191021
162MP0003634_abnormal_glial_cell0.66650558
163MP0002116_abnormal_craniofacial_bone0.66555237
164MP0003115_abnormal_respiratory_system0.66394080
165MP0004510_myositis0.65795974
166MP0001188_hyperpigmentation0.65196308

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.95297203
2Premature rupture of membranes (HP:0001788)3.97807786
3Elevated erythrocyte sedimentation rate (HP:0003565)3.65519064
4Selective tooth agenesis (HP:0001592)3.42627464
5Achilles tendon contracture (HP:0001771)3.26464472
6Peritonitis (HP:0002586)3.21165100
7Ankle contracture (HP:0006466)3.07955426
8Spinal rigidity (HP:0003306)3.05458199
9Abnormality of the Achilles tendon (HP:0005109)2.89903680
10Nonimmune hydrops fetalis (HP:0001790)2.87509009
11Shallow orbits (HP:0000586)2.80822243
12Cerebral aneurysm (HP:0004944)2.79125504
13Disproportionate tall stature (HP:0001519)2.78983333
14Cervical subluxation (HP:0003308)2.70906133
15Thrombocytosis (HP:0001894)2.64525712
16Myositis (HP:0100614)2.51535742
17Vertebral compression fractures (HP:0002953)2.51242009
18Short 4th metacarpal (HP:0010044)2.48487415
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.48487415
20Abnormality of the nasal mucosa (HP:0000433)2.46952313
21Reticulocytopenia (HP:0001896)2.46404344
22Aortic dissection (HP:0002647)2.45147762
23Obstructive sleep apnea (HP:0002870)2.44926479
24Increased connective tissue (HP:0009025)2.44887053
25Natal tooth (HP:0000695)2.43541218
26Follicular hyperkeratosis (HP:0007502)2.41292506
27Abnormality of the peritoneum (HP:0002585)2.40029934
28Biconcave vertebral bodies (HP:0004586)2.39682871
29Soft skin (HP:0000977)2.38762721
30Genu recurvatum (HP:0002816)2.37785343
31Vascular tortuosity (HP:0004948)2.37030910
32Mitral regurgitation (HP:0001653)2.30939847
33Increased variability in muscle fiber diameter (HP:0003557)2.29588988
34Elbow flexion contracture (HP:0002987)2.28282239
3511 pairs of ribs (HP:0000878)2.27142654
36Distal lower limb amyotrophy (HP:0008944)2.23121268
37Nasal polyposis (HP:0100582)2.22569647
38Hyperextensible skin (HP:0000974)2.21553256
39Mildly elevated creatine phosphokinase (HP:0008180)2.20699821
40Aortic aneurysm (HP:0004942)2.18222291
41Insomnia (HP:0100785)2.18193331
42Arterial tortuosity (HP:0005116)2.17290379
43Breech presentation (HP:0001623)2.16847520
44Dilatation of the ascending aorta (HP:0005111)2.16815797
45Abnormality of the calcaneus (HP:0008364)2.15534966
46Broad palm (HP:0001169)2.13212907
47Trismus (HP:0000211)2.11824118
48Slender long bone (HP:0003100)2.10495153
49Short nail (HP:0001799)2.09178617
50Petechiae (HP:0000967)2.09175280
51Stridor (HP:0010307)2.07274419
52Abnormality of the anterior horn cell (HP:0006802)2.06105505
53Degeneration of anterior horn cells (HP:0002398)2.06105505
54Abnormality of the acetabulum (HP:0003170)2.06082705
55Abnormal number of erythroid precursors (HP:0012131)2.06028380
56Abnormality of cells of the erythroid lineage (HP:0012130)2.04936794
57Chronic otitis media (HP:0000389)2.04609591
58Aplastic anemia (HP:0001915)2.03753685
59Basal cell carcinoma (HP:0002671)2.03427430
60Abnormality of the distal phalanges of the toes (HP:0010182)2.02794943
61Joint stiffness (HP:0001387)2.02270977
62Renal duplication (HP:0000075)2.01461480
63Blue sclerae (HP:0000592)2.00843712
64Broad face (HP:0000283)2.00563557
65Broad metatarsal (HP:0001783)2.00131716
66Slender build (HP:0001533)1.99104022
67Ulnar bowing (HP:0003031)1.97852909
68Turricephaly (HP:0000262)1.97404675
69Generalized amyotrophy (HP:0003700)1.96959065
70Radial bowing (HP:0002986)1.96947763
71Bladder diverticulum (HP:0000015)1.96212697
72Joint laxity (HP:0001388)1.95577680
73Hand muscle atrophy (HP:0009130)1.93951113
74Difficulty climbing stairs (HP:0003551)1.93709137
75Atrophic scars (HP:0001075)1.92044336
76Microretrognathia (HP:0000308)1.91322088
77Distal lower limb muscle weakness (HP:0009053)1.91279639
78Aneurysm (HP:0002617)1.91162794
79Axonal loss (HP:0003447)1.90084823
80Hypoventilation (HP:0002791)1.89545222
81Premature skin wrinkling (HP:0100678)1.88482675
82Advanced eruption of teeth (HP:0006288)1.88387095
83Pustule (HP:0200039)1.88341531
84Abnormality of skeletal muscle fiber size (HP:0012084)1.87087680
85Deviation of the thumb (HP:0009603)1.86625455
86Type 1 muscle fiber predominance (HP:0003803)1.85079533
87Thin ribs (HP:0000883)1.84477521
88Abnormality of nail color (HP:0100643)1.84433688
89Abnormality of the phalanges of the hallux (HP:0010057)1.84123547
90Metaphyseal cupping (HP:0003021)1.83516291
91Abnormality of T cells (HP:0002843)1.83062573
92Syringomyelia (HP:0003396)1.82966182
93Spinal cord lesions (HP:0100561)1.82966182
94Hyperparathyroidism (HP:0000843)1.82896401
95Asymmetry of the thorax (HP:0001555)1.82823575
96Thin bony cortex (HP:0002753)1.81816571
97Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.81581973
98Vertebral hypoplasia (HP:0008417)1.81581973
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.81349639
100Neonatal short-limb short stature (HP:0008921)1.79810945
101Recurrent viral infections (HP:0004429)1.79491079
102Breast hypoplasia (HP:0003187)1.78546862
103Coronal craniosynostosis (HP:0004440)1.78119806
104Birth length less than 3rd percentile (HP:0003561)1.77771001
105Proximal placement of thumb (HP:0009623)1.77706802
106Cellulitis (HP:0100658)1.77516831
107Recurrent bronchitis (HP:0002837)1.76355188
108Osteolytic defects of the hand bones (HP:0009699)1.76224693
109Osteolytic defects of the phalanges of the hand (HP:0009771)1.76224693
110Hyperacusis (HP:0010780)1.74961209
111Abnormality of dentin (HP:0010299)1.74790860
112Distal upper limb amyotrophy (HP:0007149)1.74681508
113Upper limb amyotrophy (HP:0009129)1.74681508
114Dysostosis multiplex (HP:0000943)1.74430772
115Neoplasm of the pancreas (HP:0002894)1.74114286
116T lymphocytopenia (HP:0005403)1.73682248
117Congenital glaucoma (HP:0001087)1.72906892
118Bowed forearm bones (HP:0003956)1.72702647
119Bowing of the arm (HP:0006488)1.72702647
120Deviation of the hallux (HP:0010051)1.72685962
121Colon cancer (HP:0003003)1.72169225
122High pitched voice (HP:0001620)1.71977033
123Deep palmar crease (HP:0006191)1.71450205
124Lower limb amyotrophy (HP:0007210)1.70990136
125Rough bone trabeculation (HP:0100670)1.70864063
126IgM deficiency (HP:0002850)1.70479165
127Hallux valgus (HP:0001822)1.70308344
128Recurrent abscess formation (HP:0002722)1.70296925
129Venous abnormality (HP:0002624)1.70170748
130Coxa vara (HP:0002812)1.69719118
131Increased density of long bones (HP:0006392)1.69248920
132Wormian bones (HP:0002645)1.69087956
133Poor head control (HP:0002421)1.67736882
134Back pain (HP:0003418)1.67597716
135Pterygium (HP:0001059)1.66678080
136Nuclear cataract (HP:0100018)1.66576454
137Ectopia lentis (HP:0001083)1.66013950
138Patellar dislocation (HP:0002999)1.65697757
139Abnormal ossification of hand bones (HP:0005921)1.65047532
140Patellar aplasia (HP:0006443)1.64869358
141Arnold-Chiari malformation (HP:0002308)1.63975897
142Abnormality of T cell number (HP:0011839)1.63910481
143Abnormality of T cell physiology (HP:0011840)1.63719252
144Leukocytosis (HP:0001974)1.63301974
145Missing ribs (HP:0000921)1.60982630
146Bicuspid aortic valve (HP:0001647)1.60852773
147Fragile skin (HP:0001030)1.60785652
148Recurrent fungal infections (HP:0002841)1.59999442
149Orchitis (HP:0100796)1.58795128
150Bowel diverticulosis (HP:0005222)1.58645835
151Mitral valve prolapse (HP:0001634)1.58398749
152Emphysema (HP:0002097)1.58247458
153Eczematoid dermatitis (HP:0000976)1.58195874
154Fatigue (HP:0012378)1.57839732
155Abnormality of the 4th metacarpal (HP:0010012)1.57703131
156Abnormality of the umbilical cord (HP:0010881)1.57449369
157Long palpebral fissure (HP:0000637)1.56975689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.11893952
2IRAK33.11688211
3SIK12.86163293
4KDR2.76722956
5ICK2.76692911
6BUB12.72862186
7TESK22.65334579
8MAP4K12.61531849
9ERN12.47343712
10WEE12.46922468
11TRIB32.38145756
12PASK2.31342525
13PRPF4B2.25516219
14EEF2K2.21904414
15PKN22.21751870
16FLT32.21735361
17NEK22.01282932
18STK101.93823153
19NME21.91878358
20RPS6KA41.91803665
21MAP3K101.87465014
22TESK11.85423200
23TGFBR11.77744029
24EPHB21.73768600
25PAK41.72923494
26IRAK41.71938642
27LRRK21.67928466
28* PTK21.67216074
29CDC71.65591576
30ACVR1B1.62954378
31NTRK11.59443867
32KIT1.56125740
33ZAP701.55976668
34JAK31.48428626
35PRKD31.45792378
36TAOK21.45340534
37BRAF1.44472136
38EPHA21.44165429
39PRKD21.39928640
40RIPK11.39341668
41TGFBR21.35136654
42PIM21.32430245
43ARAF1.32229220
44RPS6KB21.31109790
45MAP3K81.27816100
46TBK11.25161372
47BLK1.24472061
48DYRK31.24376588
49MAP3K111.23772818
50MAP2K31.22514200
51BTK1.22369694
52CDK71.19940652
53TYK21.14711057
54TTN1.13217581
55MAP3K31.12935151
56MST1R1.12719054
57AKT31.12575075
58RPS6KA21.10992070
59CLK11.08866321
60BRSK21.07929304
61CDC42BPA1.07910559
62ITK1.04274313
63PTK61.01908849
64CAMK1D0.93329100
65SCYL20.93316581
66LMTK20.92569761
67TXK0.90293691
68ATR0.89244627
69ABL20.88782316
70MAPKAPK30.88540993
71CSF1R0.88051602
72TAF10.85585523
73EIF2AK10.85547021
74PLK10.84893246
75TTK0.83544242
76BMX0.83470988
77FGFR40.82481755
78PAK20.82234659
79HIPK20.81720310
80AURKB0.81364304
81TYRO30.79572872
82PRKG20.78550051
83CDK40.78288300
84PIM10.78262749
85CSK0.77658867
86RPS6KL10.74192246
87RPS6KC10.74192246
88DDR20.74124598
89TAOK10.72752281
90TEC0.72433590
91IKBKE0.72414300
92TSSK60.71775674
93PDGFRA0.71433166
94MARK20.71261731
95IKBKB0.70383962
96PDPK10.69890866
97KSR20.69453641
98GRK60.66809847
99PAK10.65270345
100MAP3K10.64724886
101CDK120.64344999
102LCK0.64055022
103STK40.63154183
104MTOR0.62893491
105EPHB10.61219338
106DMPK0.61113705
107STK380.60390016
108DYRK1B0.59122163
109VRK10.57970868
110ILK0.57706572
111MAP3K60.56599627
112CAMK1G0.56412720
113MAP3K90.55352607
114MYLK0.55197436
115CHUK0.54744171
116IRAK20.54420287
117RPS6KA60.53869638
118STK30.53774093
119SRPK10.53451810
120LATS20.52614689
121PRKCI0.51868655
122ERBB40.51687792
123CHEK10.51464052
124PDGFRB0.51429507
125MAP3K130.51222820
126HCK0.50145301
127PLK40.49604024
128AURKA0.48186276
129LIMK10.47915852
130CHEK20.47037780
131DAPK30.46986388
132MOS0.46106368
133EIF2AK30.44199636
134MAP2K20.44113860
135MAPKAPK20.43367655
136TRPM70.42904935
137CDK90.41732976
138MET0.41047104
139LYN0.39758354
140KSR10.39203448
141NEK10.38335942
142SYK0.37985481
143FGFR10.37234455
144GSK3A0.37109847
145CDK80.36923499
146TIE10.35925360
147BRSK10.35856221
148MATK0.35710773
149AKT20.34797864
150ROCK20.34100330
151CDK60.33564020
152SGK30.32845314
153MAPK110.31228978
154CDK11A0.31218056
155PAK60.29187547
156CDK150.28882926
157MAP2K10.27787054

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.68710438
2Mismatch repair_Homo sapiens_hsa034302.72332300
3Base excision repair_Homo sapiens_hsa034102.64397974
4Ribosome_Homo sapiens_hsa030102.48568997
5Spliceosome_Homo sapiens_hsa030402.33419847
6Cell cycle_Homo sapiens_hsa041102.15702346
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99369574
8Proteasome_Homo sapiens_hsa030501.92991854
9p53 signaling pathway_Homo sapiens_hsa041151.90730276
10Prion diseases_Homo sapiens_hsa050201.90289446
11RNA transport_Homo sapiens_hsa030131.90037389
12Nucleotide excision repair_Homo sapiens_hsa034201.88085168
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.82767091
14Primary immunodeficiency_Homo sapiens_hsa053401.80612820
15Antigen processing and presentation_Homo sapiens_hsa046121.78811528
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76407240
17Homologous recombination_Homo sapiens_hsa034401.70453250
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65331003
19One carbon pool by folate_Homo sapiens_hsa006701.62011065
20RNA polymerase_Homo sapiens_hsa030201.55751387
21Pyrimidine metabolism_Homo sapiens_hsa002401.50665566
22Amoebiasis_Homo sapiens_hsa051461.49220587
23Shigellosis_Homo sapiens_hsa051311.45385992
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45281614
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.44546952
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44377660
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35143893
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34110751
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.33789450
30Glioma_Homo sapiens_hsa052141.29416251
31Measles_Homo sapiens_hsa051621.28968407
32Herpes simplex infection_Homo sapiens_hsa051681.28798440
33Small cell lung cancer_Homo sapiens_hsa052221.28495862
34Legionellosis_Homo sapiens_hsa051341.27549127
35Endometrial cancer_Homo sapiens_hsa052131.26401467
36Renal cell carcinoma_Homo sapiens_hsa052111.25973376
37Non-small cell lung cancer_Homo sapiens_hsa052231.25344585
38Viral carcinogenesis_Homo sapiens_hsa052031.23712180
39Epstein-Barr virus infection_Homo sapiens_hsa051691.22909627
40Vitamin B6 metabolism_Homo sapiens_hsa007501.22254246
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.21651058
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21102030
43Leishmaniasis_Homo sapiens_hsa051401.19982837
44HTLV-I infection_Homo sapiens_hsa051661.19441449
45Fructose and mannose metabolism_Homo sapiens_hsa000511.16848560
46Apoptosis_Homo sapiens_hsa042101.16051450
47Non-homologous end-joining_Homo sapiens_hsa034501.13192994
48Chronic myeloid leukemia_Homo sapiens_hsa052201.12005163
49Vibrio cholerae infection_Homo sapiens_hsa051101.09217687
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06540683
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.05201520
52Protein digestion and absorption_Homo sapiens_hsa049741.04876094
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04835171
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04788390
55ErbB signaling pathway_Homo sapiens_hsa040121.04626407
56Acute myeloid leukemia_Homo sapiens_hsa052211.01594648
57Hepatitis B_Homo sapiens_hsa051611.01226014
58Hematopoietic cell lineage_Homo sapiens_hsa046401.01007489
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99046355
60Fanconi anemia pathway_Homo sapiens_hsa034600.97436232
61RNA degradation_Homo sapiens_hsa030180.97291972
62Biosynthesis of amino acids_Homo sapiens_hsa012300.97214028
63ECM-receptor interaction_Homo sapiens_hsa045120.96898244
64mTOR signaling pathway_Homo sapiens_hsa041500.96752399
65Insulin signaling pathway_Homo sapiens_hsa049100.95944868
66Viral myocarditis_Homo sapiens_hsa054160.95573824
67B cell receptor signaling pathway_Homo sapiens_hsa046620.95188348
68Toxoplasmosis_Homo sapiens_hsa051450.91986152
69MicroRNAs in cancer_Homo sapiens_hsa052060.91904220
70Malaria_Homo sapiens_hsa051440.91890932
71Prostate cancer_Homo sapiens_hsa052150.91858330
72mRNA surveillance pathway_Homo sapiens_hsa030150.91769697
73GnRH signaling pathway_Homo sapiens_hsa049120.91276123
74Bladder cancer_Homo sapiens_hsa052190.91250413
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.90948706
76AMPK signaling pathway_Homo sapiens_hsa041520.90405646
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89595336
78Notch signaling pathway_Homo sapiens_hsa043300.89396905
79Estrogen signaling pathway_Homo sapiens_hsa049150.87900717
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87871748
81Melanoma_Homo sapiens_hsa052180.87757053
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85313913
83* Endocytosis_Homo sapiens_hsa041440.85293048
84T cell receptor signaling pathway_Homo sapiens_hsa046600.84237370
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83010335
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82968596
87Focal adhesion_Homo sapiens_hsa045100.82642658
88Osteoclast differentiation_Homo sapiens_hsa043800.82641600
89Basal transcription factors_Homo sapiens_hsa030220.82083504
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81189692
91Thyroid cancer_Homo sapiens_hsa052160.80382440
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80358866
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79688740
94Melanogenesis_Homo sapiens_hsa049160.79626295
95Axon guidance_Homo sapiens_hsa043600.77821417
96Rap1 signaling pathway_Homo sapiens_hsa040150.77151248
97N-Glycan biosynthesis_Homo sapiens_hsa005100.76759655
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.76495747
99Proteoglycans in cancer_Homo sapiens_hsa052050.75200468
100Pancreatic cancer_Homo sapiens_hsa052120.75005444
101Pentose phosphate pathway_Homo sapiens_hsa000300.74315914
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.74105977
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73750620
104Colorectal cancer_Homo sapiens_hsa052100.73122534
105TNF signaling pathway_Homo sapiens_hsa046680.72378472
106Influenza A_Homo sapiens_hsa051640.71793016
107Hepatitis C_Homo sapiens_hsa051600.71118246
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70181704
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68092590
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66953380
111Other glycan degradation_Homo sapiens_hsa005110.64664272
112Tight junction_Homo sapiens_hsa045300.64376113
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.64114013
114Hippo signaling pathway_Homo sapiens_hsa043900.64059053
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62858694
116Platelet activation_Homo sapiens_hsa046110.62794480
117Folate biosynthesis_Homo sapiens_hsa007900.62441228
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62081466
119Sulfur relay system_Homo sapiens_hsa041220.60699612
120Adherens junction_Homo sapiens_hsa045200.60387049
121Hedgehog signaling pathway_Homo sapiens_hsa043400.60177152
122Lysosome_Homo sapiens_hsa041420.60155549
123TGF-beta signaling pathway_Homo sapiens_hsa043500.60060165
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.59712508
125HIF-1 signaling pathway_Homo sapiens_hsa040660.59357534
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.58960765
127Sphingolipid metabolism_Homo sapiens_hsa006000.58036438
128Purine metabolism_Homo sapiens_hsa002300.58022053
129Pathways in cancer_Homo sapiens_hsa052000.57172252
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56826133
131Lysine degradation_Homo sapiens_hsa003100.56612039
132Dilated cardiomyopathy_Homo sapiens_hsa054140.56272853
133Galactose metabolism_Homo sapiens_hsa000520.55910680
134Gap junction_Homo sapiens_hsa045400.55532024
135Systemic lupus erythematosus_Homo sapiens_hsa053220.54360765
136Prolactin signaling pathway_Homo sapiens_hsa049170.54357612
137Protein export_Homo sapiens_hsa030600.53920409
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53915006
139Basal cell carcinoma_Homo sapiens_hsa052170.53466078
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53258357
141VEGF signaling pathway_Homo sapiens_hsa043700.53107334
142Pertussis_Homo sapiens_hsa051330.53099452
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53098217
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53058222
145Salmonella infection_Homo sapiens_hsa051320.51363692
146Choline metabolism in cancer_Homo sapiens_hsa052310.50391002
147Wnt signaling pathway_Homo sapiens_hsa043100.47226712
148MAPK signaling pathway_Homo sapiens_hsa040100.46805840
149Sulfur metabolism_Homo sapiens_hsa009200.46724427
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46540280
151Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45317846

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