SH3GL1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)4.95647733
2NIK/NF-kappaB signaling (GO:0038061)4.47545431
3activated T cell proliferation (GO:0050798)4.29329486
4behavioral response to nicotine (GO:0035095)3.88882906
5ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.86000568
6proline transport (GO:0015824)3.83925967
7negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.80303994
8negative regulation of translation, ncRNA-mediated (GO:0040033)3.80303994
9regulation of translation, ncRNA-mediated (GO:0045974)3.80303994
10negative regulation of B cell mediated immunity (GO:0002713)3.74711464
11negative regulation of immunoglobulin mediated immune response (GO:0002890)3.74711464
12positive T cell selection (GO:0043368)3.68013819
13protein K11-linked deubiquitination (GO:0035871)3.48358409
14positive regulation of CREB transcription factor activity (GO:0032793)3.41413794
15positive regulation of granulocyte differentiation (GO:0030854)3.32365179
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.30863725
17cerebellar Purkinje cell differentiation (GO:0021702)3.28860224
18negative T cell selection (GO:0043383)3.28670998
19histone H3-K4 trimethylation (GO:0080182)3.24510346
20cerebral cortex radially oriented cell migration (GO:0021799)3.22360483
21DNA double-strand break processing (GO:0000729)3.21904420
22regulation of B cell receptor signaling pathway (GO:0050855)3.21400551
23snRNA transcription (GO:0009301)3.15627809
24negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.15286528
25neural tube formation (GO:0001841)3.14712302
26pyrimidine nucleobase catabolic process (GO:0006208)3.09386109
27negative regulation of granulocyte differentiation (GO:0030853)3.01467010
28regulation of granulocyte differentiation (GO:0030852)2.99115806
29negative thymic T cell selection (GO:0045060)2.97126980
30dopamine transport (GO:0015872)2.96099974
31mRNA splice site selection (GO:0006376)2.93787430
32somite development (GO:0061053)2.91152802
33negative regulation of cAMP-mediated signaling (GO:0043951)2.89917969
34response to pheromone (GO:0019236)2.88825360
35establishment of mitochondrion localization (GO:0051654)2.88023232
36transmission of nerve impulse (GO:0019226)2.87946723
37alpha-beta T cell differentiation (GO:0046632)2.85800259
38indolalkylamine metabolic process (GO:0006586)2.85611757
39mucosal-associated lymphoid tissue development (GO:0048537)2.82928475
40Peyers patch development (GO:0048541)2.82928475
41interferon-gamma production (GO:0032609)2.81290258
42detection of light stimulus involved in sensory perception (GO:0050962)2.80733122
43detection of light stimulus involved in visual perception (GO:0050908)2.80733122
44purine deoxyribonucleotide catabolic process (GO:0009155)2.79959567
45tolerance induction (GO:0002507)2.79655825
46olfactory bulb development (GO:0021772)2.75912406
47T cell selection (GO:0045058)2.74127943
48negative regulation of organelle assembly (GO:1902116)2.73276819
49positive regulation by host of viral transcription (GO:0043923)2.73189365
50regulation of isotype switching to IgG isotypes (GO:0048302)2.71411166
51regulation of gamma-delta T cell differentiation (GO:0045586)2.67163040
52phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.66572003
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.61973378
54positive regulation of gamma-delta T cell activation (GO:0046645)2.58331917
55histone H2A acetylation (GO:0043968)2.57571940
56purine deoxyribonucleotide metabolic process (GO:0009151)2.57049424
57positive regulation of protein deacetylation (GO:0090312)2.57037112
58neuronal action potential (GO:0019228)2.56421978
59establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.56018106
60mitochondrion transport along microtubule (GO:0047497)2.56018106
61regulation of memory T cell differentiation (GO:0043380)2.55958700
62dentate gyrus development (GO:0021542)2.54936801
63I-kappaB phosphorylation (GO:0007252)2.54612289
64negative regulation of lymphocyte mediated immunity (GO:0002707)2.52519646
65phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.51370168
66mast cell degranulation (GO:0043303)2.51178178
67mast cell activation involved in immune response (GO:0002279)2.51178178
68fucose catabolic process (GO:0019317)2.50540444
69L-fucose metabolic process (GO:0042354)2.50540444
70L-fucose catabolic process (GO:0042355)2.50540444
71purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.49699364
72regulation of B cell differentiation (GO:0045577)2.46962549
73Arp2/3 complex-mediated actin nucleation (GO:0034314)2.46336857
74nucleobase catabolic process (GO:0046113)2.45526361
75regulation of gamma-delta T cell activation (GO:0046643)2.44178234
76positive thymic T cell selection (GO:0045059)2.43598356
77mast cell activation (GO:0045576)2.43272354
78negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.41821794
79atrial cardiac muscle cell action potential (GO:0086014)2.41493008
80actin nucleation (GO:0045010)2.40534329
81negative regulation of interleukin-1 beta production (GO:0032691)2.39233928
82response to interleukin-15 (GO:0070672)2.38730775
83alpha-beta T cell activation (GO:0046631)2.38174520
84adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.38098244
85regulation of Rab GTPase activity (GO:0032313)2.37766655
86positive regulation of Rab GTPase activity (GO:0032851)2.37766655
87negative regulation of neurotransmitter transport (GO:0051589)2.37038561
88histone H3-K4 methylation (GO:0051568)2.36393654
89negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.36323923
90histone H3-K9 modification (GO:0061647)2.34621034
91substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.34613056
92substrate-independent telencephalic tangential migration (GO:0021826)2.34613056
93interkinetic nuclear migration (GO:0022027)2.34591249
94regulation of protein deacetylation (GO:0090311)2.34499103
95catecholamine transport (GO:0051937)2.34387661
96regulation of interleukin-6 biosynthetic process (GO:0045408)2.32696440
97leukocyte aggregation (GO:0070486)2.30244011
98positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.29446830
99regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.29446830
100regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.29208035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.72463483
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.29849820
3ZNF274_21170338_ChIP-Seq_K562_Hela3.27777363
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61002380
5IGF1R_20145208_ChIP-Seq_DFB_Human2.47165732
6EZH2_22144423_ChIP-Seq_EOC_Human2.39212026
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37318282
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.33767359
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18896540
10SCL_19346495_ChIP-Seq_HPC-7_Human2.05605684
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04085239
12RUNX_20019798_ChIP-Seq_JUKART_Human2.00097312
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99393850
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98510001
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91115405
16VDR_22108803_ChIP-Seq_LS180_Human1.83073801
17REST_21632747_ChIP-Seq_MESCs_Mouse1.73688454
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73202259
19TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71330308
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71330308
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.69178319
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.68565832
23MYB_26560356_Chip-Seq_TH2_Human1.68417373
24DROSHA_22980978_ChIP-Seq_HELA_Human1.66160596
25GATA3_27048872_Chip-Seq_THYMUS_Human1.62653432
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.49433188
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47093655
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44339071
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41863620
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38846468
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33828786
32BCAT_22108803_ChIP-Seq_LS180_Human1.33398691
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29680805
34STAT3_23295773_ChIP-Seq_U87_Human1.28610141
35* GATA3_26560356_Chip-Seq_TH2_Human1.27218659
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26392636
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24648471
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24176585
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.24117897
40UTX_26944678_Chip-Seq_JUKART_Human1.23918706
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22674306
42TP53_22573176_ChIP-Seq_HFKS_Human1.22516011
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19756351
44MYB_26560356_Chip-Seq_TH1_Human1.18780570
45VDR_24787735_ChIP-Seq_THP-1_Human1.17937581
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.17841313
47GBX2_23144817_ChIP-Seq_PC3_Human1.17108728
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16916517
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16899040
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16395852
51TAF15_26573619_Chip-Seq_HEK293_Human1.15943062
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14319151
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13234153
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.12994341
55TCF4_23295773_ChIP-Seq_U87_Human1.11515335
56MYC_22102868_ChIP-Seq_BL_Human1.11079032
57ER_23166858_ChIP-Seq_MCF-7_Human1.09934433
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.09712015
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09369245
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08407137
61MAF_26560356_Chip-Seq_TH2_Human1.08364052
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08060761
63KDM2B_26808549_Chip-Seq_DND41_Human1.07984582
64CBP_20019798_ChIP-Seq_JUKART_Human1.06534514
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06534514
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05786387
67SMRT_27268052_Chip-Seq_Bcells_Human1.05662710
68WDR5_24793694_ChIP-Seq_LNCAP_Human1.05221267
69* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.03703433
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.03674674
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02590568
72RNF2_27304074_Chip-Seq_NSC_Mouse1.01196793
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01191059
74PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00231887
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00058485
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99530448
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98663638
78JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98627609
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97558615
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97337325
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97239689
82ERA_21632823_ChIP-Seq_H3396_Human0.96022466
83FLI1_27457419_Chip-Seq_LIVER_Mouse0.95706655
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95026489
85SALL1_21062744_ChIP-ChIP_HESCs_Human0.94780419
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92982460
87MYC_19829295_ChIP-Seq_ESCs_Human0.92199547
88VDR_24763502_ChIP-Seq_THP-1_Human0.91141120
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90610556
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90407712
91MAF_26560356_Chip-Seq_TH1_Human0.90161910
92KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89386966
93RXR_22108803_ChIP-Seq_LS180_Human0.89192677
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87755003
95OCT4_19829295_ChIP-Seq_ESCs_Human0.86891872
96EWS_26573619_Chip-Seq_HEK293_Human0.86200167
97RUNX2_22187159_ChIP-Seq_PCA_Human0.85556678
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84466268
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84439561
100GATA3_26560356_Chip-Seq_TH1_Human0.84216105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.25734960
2MP0006292_abnormal_olfactory_placode3.06841012
3MP0000569_abnormal_digit_pigmentation3.01059268
4MP0005075_abnormal_melanosome_morpholog2.98514120
5MP0000015_abnormal_ear_pigmentation2.49215622
6MP0003880_abnormal_central_pattern2.44838543
7MP0002102_abnormal_ear_morphology2.37364859
8MP0001986_abnormal_taste_sensitivity2.29509492
9MP0003787_abnormal_imprinting2.26502080
10MP0004381_abnormal_hair_follicle2.23785593
11MP0005174_abnormal_tail_pigmentation2.14036450
12MP0002638_abnormal_pupillary_reflex1.91517072
13MP0001968_abnormal_touch/_nociception1.88753474
14MP0008057_abnormal_DNA_replication1.85673053
15MP0004142_abnormal_muscle_tone1.83857137
16MP0005671_abnormal_response_to1.81111279
17MP0001800_abnormal_humoral_immune1.80703307
18MP0009046_muscle_twitch1.77846979
19MP0003878_abnormal_ear_physiology1.69413329
20MP0005377_hearing/vestibular/ear_phenot1.69413329
21MP0002009_preneoplasia1.68551421
22MP0008877_abnormal_DNA_methylation1.63404003
23MP0001188_hyperpigmentation1.62254624
24MP0003763_abnormal_thymus_physiology1.60910846
25MP0000778_abnormal_nervous_system1.57074781
26MP0002928_abnormal_bile_duct1.52224437
27MP0003436_decreased_susceptibility_to1.50982738
28MP0002095_abnormal_skin_pigmentation1.50828912
29MP0005551_abnormal_eye_electrophysiolog1.49192793
30MP0003646_muscle_fatigue1.47394936
31MP0000371_diluted_coat_color1.41608171
32MP0003635_abnormal_synaptic_transmissio1.41286050
33MP0002723_abnormal_immune_serum1.40291080
34MP0003172_abnormal_lysosome_physiology1.39066423
35MP0000703_abnormal_thymus_morphology1.37780709
36MP0005423_abnormal_somatic_nervous1.36050311
37MP0005387_immune_system_phenotype1.35901019
38MP0001790_abnormal_immune_system1.35901019
39MP0000685_abnormal_immune_system1.35589780
40MP0002405_respiratory_system_inflammati1.35343585
41MP0002420_abnormal_adaptive_immunity1.35043821
42MP0001501_abnormal_sleep_pattern1.34431588
43MP0001819_abnormal_immune_cell1.33857559
44MP0004130_abnormal_muscle_cell1.31548308
45MP0005386_behavior/neurological_phenoty1.29951199
46MP0004924_abnormal_behavior1.29951199
47MP0005645_abnormal_hypothalamus_physiol1.29372518
48MP0002396_abnormal_hematopoietic_system1.29064176
49MP0001835_abnormal_antigen_presentation1.27770407
50MP0009745_abnormal_behavioral_response1.27201076
51MP0002067_abnormal_sensory_capabilities1.24077239
52MP0006276_abnormal_autonomic_nervous1.16252513
53MP0002398_abnormal_bone_marrow1.15768212
54MP0005025_abnormal_response_to1.15394570
55MP0005000_abnormal_immune_tolerance1.14825085
56MP0000427_abnormal_hair_cycle1.13068649
57MP0000689_abnormal_spleen_morphology1.12161192
58MP0002452_abnormal_antigen_presenting1.11837947
59MP0002063_abnormal_learning/memory/cond1.11768852
60MP0000716_abnormal_immune_system1.11205087
61MP0008995_early_reproductive_senescence1.06534228
62MP0002272_abnormal_nervous_system1.06425230
63MP0002138_abnormal_hepatobiliary_system1.06037898
64MP0002736_abnormal_nociception_after1.05541120
65MP0004133_heterotaxia1.04631964
66MP0002572_abnormal_emotion/affect_behav1.04152158
67MP0003724_increased_susceptibility_to1.02558077
68MP0009764_decreased_sensitivity_to1.00294644
69MP0009785_altered_susceptibility_to0.99893832
70MP0004742_abnormal_vestibular_system0.96929719
71MP0002064_seizures0.96691175
72MP0004885_abnormal_endolymph0.94807675
73MP0004859_abnormal_synaptic_plasticity0.94327666
74MP0003121_genomic_imprinting0.91256605
75MP0005499_abnormal_olfactory_system0.90545420
76MP0005394_taste/olfaction_phenotype0.90545420
77MP0001485_abnormal_pinna_reflex0.90404077
78MP0003122_maternal_imprinting0.90288418
79MP0003567_abnormal_fetal_cardiomyocyte0.89409306
80MP0002419_abnormal_innate_immunity0.88690590
81MP0002229_neurodegeneration0.87951165
82MP0002722_abnormal_immune_system0.87372913
83MP0002933_joint_inflammation0.87184733
84MP0000631_abnormal_neuroendocrine_gland0.86678777
85MP0002557_abnormal_social/conspecific_i0.84742797
86MP0001905_abnormal_dopamine_level0.84045364
87MP0004147_increased_porphyrin_level0.83761000
88MP0005084_abnormal_gallbladder_morpholo0.82633474
89MP0000955_abnormal_spinal_cord0.82229187
90MP0009765_abnormal_xenobiotic_induced0.80722659
91MP0001324_abnormal_eye_pigmentation0.79794418
92MP0002882_abnormal_neuron_morphology0.79075950
93MP0006082_CNS_inflammation0.77217695
94MP0008058_abnormal_DNA_repair0.76690377
95MP0001502_abnormal_circadian_rhythm0.76267275
96MP0009333_abnormal_splenocyte_physiolog0.76012519
97MP0002752_abnormal_somatic_nervous0.74354879
98MP0005535_abnormal_body_temperature0.74182687
99MP0003303_peritoneal_inflammation0.73948162
100MP0002429_abnormal_blood_cell0.73802810

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.09439094
2Congenital stationary night blindness (HP:0007642)3.98974211
3Pancreatic fibrosis (HP:0100732)3.72648587
4Febrile seizures (HP:0002373)3.65797579
5Genetic anticipation (HP:0003743)3.58721031
6Severe combined immunodeficiency (HP:0004430)3.27963565
7Tented upper lip vermilion (HP:0010804)3.20794100
8Pancreatic cysts (HP:0001737)3.14939082
9Atonic seizures (HP:0010819)3.12757461
10Elevated erythrocyte sedimentation rate (HP:0003565)3.07416345
11Stomatitis (HP:0010280)3.06139755
12Absent speech (HP:0001344)3.00880211
13Panhypogammaglobulinemia (HP:0003139)2.98424570
14Abnormal delayed hypersensitivity skin test (HP:0002963)2.91178420
15Progressive cerebellar ataxia (HP:0002073)2.87055087
16Gaze-evoked nystagmus (HP:0000640)2.79278203
17Decreased central vision (HP:0007663)2.74886197
18Broad-based gait (HP:0002136)2.74118559
19Amyotrophic lateral sclerosis (HP:0007354)2.66527922
20Stomach cancer (HP:0012126)2.65919691
21Thyroiditis (HP:0100646)2.65255952
22Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62776694
23Abnormal rod and cone electroretinograms (HP:0008323)2.60936494
24Ocular albinism (HP:0001107)2.58470375
25Drooling (HP:0002307)2.55091337
26Excessive salivation (HP:0003781)2.54388167
27Recurrent cutaneous fungal infections (HP:0011370)2.46333747
28Chronic mucocutaneous candidiasis (HP:0002728)2.46333747
29True hermaphroditism (HP:0010459)2.44755270
30Diastasis recti (HP:0001540)2.41316205
31Combined immunodeficiency (HP:0005387)2.29180087
32Clumsiness (HP:0002312)2.26293933
33Epileptic encephalopathy (HP:0200134)2.25907027
34Hypoplastic iliac wings (HP:0002866)2.25905853
35Hypothermia (HP:0002045)2.25295865
36Protruding tongue (HP:0010808)2.25000170
37Thyroid-stimulating hormone excess (HP:0002925)2.23429083
38Encephalitis (HP:0002383)2.21839319
39Abnormality of B cell number (HP:0010975)2.19372228
40Type II lissencephaly (HP:0007260)2.19067082
41Molar tooth sign on MRI (HP:0002419)2.18584677
42Abnormality of midbrain morphology (HP:0002418)2.18584677
43Iris hypopigmentation (HP:0007730)2.17514903
44Cystic liver disease (HP:0006706)2.15578600
45Abnormality of eosinophils (HP:0001879)2.15099940
46Recurrent fungal infections (HP:0002841)2.13726021
47Neoplasm of the tracheobronchial system (HP:0100552)2.12896437
48Attenuation of retinal blood vessels (HP:0007843)2.09207715
49Alveolar cell carcinoma (HP:0006519)2.06965236
50Lissencephaly (HP:0001339)2.06394587
51Abnormality of the fingertips (HP:0001211)2.06358284
52Nephronophthisis (HP:0000090)2.06053230
53Pachygyria (HP:0001302)2.04481661
54Progressive microcephaly (HP:0000253)2.02740911
55Dyskinesia (HP:0100660)1.97476766
56Abnormality of the renal medulla (HP:0100957)1.97321294
57IgG deficiency (HP:0004315)1.96691675
58Abnormality of the renal cortex (HP:0011035)1.95114682
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93581937
60Prolonged QT interval (HP:0001657)1.93347284
61Obstructive sleep apnea (HP:0002870)1.92491272
62Dialeptic seizures (HP:0011146)1.91335753
63Leukocytosis (HP:0001974)1.90649963
64Polydipsia (HP:0001959)1.90551174
65Abnormal drinking behavior (HP:0030082)1.90551174
66Spastic gait (HP:0002064)1.89416330
67Gait imbalance (HP:0002141)1.89173571
68Abnormality of lateral ventricle (HP:0030047)1.88456340
69Stereotypic behavior (HP:0000733)1.88289159
70Widely spaced teeth (HP:0000687)1.87020657
71Autoimmune hemolytic anemia (HP:0001890)1.84651146
72Urinary bladder sphincter dysfunction (HP:0002839)1.82511824
73T lymphocytopenia (HP:0005403)1.82285983
74B lymphocytopenia (HP:0010976)1.80164846
75Bile duct proliferation (HP:0001408)1.79649812
76Abnormal biliary tract physiology (HP:0012439)1.79649812
77Shawl scrotum (HP:0000049)1.75760190
78Abnormality of T cells (HP:0002843)1.75262306
79Myositis (HP:0100614)1.75222368
80Prominent nose (HP:0000448)1.75130240
81Recurrent skin infections (HP:0001581)1.74204386
82Anencephaly (HP:0002323)1.74138510
83Intellectual disability, severe (HP:0010864)1.73556857
84Congenital hepatic fibrosis (HP:0002612)1.73203130
85Aqueductal stenosis (HP:0002410)1.72972659
86Ectopic kidney (HP:0000086)1.72912026
87Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72193667
88Patellar aplasia (HP:0006443)1.70803551
89Mediastinal lymphadenopathy (HP:0100721)1.69279034
90Poor eye contact (HP:0000817)1.69211053
91Chronic hepatic failure (HP:0100626)1.67969932
92Oligodactyly (hands) (HP:0001180)1.67765194
93Increased neuronal autofluorescent lipopigment (HP:0002074)1.67637424
94Absence seizures (HP:0002121)1.67064029
95Bony spicule pigmentary retinopathy (HP:0007737)1.66874854
96Increased IgM level (HP:0003496)1.66159673
97Pendular nystagmus (HP:0012043)1.66134449
98Sleep apnea (HP:0010535)1.65476255
99Cerebellar dysplasia (HP:0007033)1.64701021
100Deep palmar crease (HP:0006191)1.64496725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK133.39364901
2FRK3.27029492
3CASK2.83929894
4IKBKE2.40605398
5SIK22.34979267
6TNK22.11676007
7MARK12.04730145
8TXK1.88721032
9SIK31.84684715
10NUAK11.79917045
11TAOK31.76494670
12SGK21.59694195
13CAMKK21.57557136
14DYRK1B1.55195277
15MAP4K11.51183562
16MARK31.45524129
17UHMK11.43732402
18PINK11.41932682
19AKT31.36576151
20WNK31.32154233
21MARK21.32033287
22CAMK1G1.27727848
23CAMK1D1.25597711
24STK381.24838177
25TRIM281.23365670
26GRK61.20687840
27CAMK41.18269658
28PRKCQ1.16815813
29MAP3K101.16745973
30NTRK21.13985289
31BTK1.11862712
32CAMKK11.11700447
33MAP3K61.10443687
34MAP3K41.09106926
35DAPK21.08896444
36ZAP701.08395162
37SGK4941.08302828
38SGK2231.08302828
39ITK1.07075628
40BMPR1B1.05865782
41ADRBK21.05321198
42KIT1.01868506
43DYRK20.99151604
44ERN10.98896004
45DYRK1A0.97810878
46SYK0.96350869
47FES0.95137866
48INSRR0.93315623
49HIPK20.90342389
50IKBKB0.90338535
51TRIB30.89170018
52CAMK10.88341495
53LCK0.86164057
54GRK10.82457455
55PKN10.81540522
56SGK30.81481379
57TEC0.80554490
58CDK190.80508975
59BRD40.78456404
60ZAK0.75563119
61PRKD30.74208537
62PRKCZ0.72033603
63STK110.71795043
64MAP2K60.68989285
65LYN0.68966100
66SIK10.67983176
67RPS6KA60.67428549
68ACVR1B0.65617614
69MAPK70.65468284
70MAP3K70.64606226
71MAP2K40.63469992
72PDK10.63315802
73PAK30.63134665
74PRKAA10.61328742
75PRKCH0.60547544
76EPHA40.59702213
77MAPK80.59491990
78TYK20.57678233
79MAP3K140.57353587
80CHUK0.56946923
81PRKD20.56327363
82STK160.54449361
83PIK3CG0.53845832
84SGK10.53715274
85WNK10.53343221
86RPS6KA20.53211391
87PRKAA20.52232584
88HCK0.51395992
89RPS6KC10.49795893
90RPS6KL10.49795893
91MAP3K110.49635090
92CSNK1D0.46656590
93PIM10.46552033
94TAF10.46253513
95MAP2K70.46134447
96MAPK120.46026318
97MKNK20.45931198
98BCKDK0.45666252
99RPS6KA10.44962356
100MAP2K30.43874613

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.87752378
2T cell receptor signaling pathway_Homo sapiens_hsa046602.59273494
3Nicotine addiction_Homo sapiens_hsa050332.15601626
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97106233
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.96096833
6Phototransduction_Homo sapiens_hsa047441.87184015
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86653021
8Morphine addiction_Homo sapiens_hsa050321.74190625
9Dorso-ventral axis formation_Homo sapiens_hsa043201.70173022
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65380239
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60688016
12Acute myeloid leukemia_Homo sapiens_hsa052211.58976185
13B cell receptor signaling pathway_Homo sapiens_hsa046621.58940262
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57872494
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51768580
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49668316
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38903649
18Osteoclast differentiation_Homo sapiens_hsa043801.38378879
19Lysine degradation_Homo sapiens_hsa003101.34921856
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33765111
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30674942
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.29896447
23Measles_Homo sapiens_hsa051621.29320366
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.27071500
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24642895
26Regulation of autophagy_Homo sapiens_hsa041401.24317678
27Non-small cell lung cancer_Homo sapiens_hsa052231.22133425
28Cholinergic synapse_Homo sapiens_hsa047251.17275923
29Fanconi anemia pathway_Homo sapiens_hsa034601.13901837
30Circadian entrainment_Homo sapiens_hsa047131.11512251
31FoxO signaling pathway_Homo sapiens_hsa040681.08440021
32Long-term depression_Homo sapiens_hsa047301.07747041
33MAPK signaling pathway_Homo sapiens_hsa040101.05532022
34GABAergic synapse_Homo sapiens_hsa047271.04818537
35mTOR signaling pathway_Homo sapiens_hsa041501.04456098
36Oxytocin signaling pathway_Homo sapiens_hsa049211.02469414
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01386909
38Taste transduction_Homo sapiens_hsa047421.00708484
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99443815
40Inositol phosphate metabolism_Homo sapiens_hsa005620.98104599
41TNF signaling pathway_Homo sapiens_hsa046680.98077671
42Homologous recombination_Homo sapiens_hsa034400.96998324
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95225318
44Chemokine signaling pathway_Homo sapiens_hsa040620.93656207
45Dopaminergic synapse_Homo sapiens_hsa047280.93274521
46Cocaine addiction_Homo sapiens_hsa050300.93198977
47Glutamatergic synapse_Homo sapiens_hsa047240.92042911
48Hepatitis B_Homo sapiens_hsa051610.91919989
49Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91445280
50Colorectal cancer_Homo sapiens_hsa052100.90146036
51Type II diabetes mellitus_Homo sapiens_hsa049300.89394227
52Non-homologous end-joining_Homo sapiens_hsa034500.89153444
53ErbB signaling pathway_Homo sapiens_hsa040120.86938184
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84724963
55Nitrogen metabolism_Homo sapiens_hsa009100.83907756
56Platelet activation_Homo sapiens_hsa046110.83818165
57Hematopoietic cell lineage_Homo sapiens_hsa046400.83039415
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81644775
59Glycerolipid metabolism_Homo sapiens_hsa005610.81136681
60Axon guidance_Homo sapiens_hsa043600.80949129
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79968549
62Tuberculosis_Homo sapiens_hsa051520.76707011
63Herpes simplex infection_Homo sapiens_hsa051680.75726689
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74956540
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74919062
66cAMP signaling pathway_Homo sapiens_hsa040240.74569304
67Selenocompound metabolism_Homo sapiens_hsa004500.72638868
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72493936
69Choline metabolism in cancer_Homo sapiens_hsa052310.72295122
70Chronic myeloid leukemia_Homo sapiens_hsa052200.72290991
71Linoleic acid metabolism_Homo sapiens_hsa005910.72284436
72Serotonergic synapse_Homo sapiens_hsa047260.71764897
73Long-term potentiation_Homo sapiens_hsa047200.69602804
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67723051
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67379136
76Prolactin signaling pathway_Homo sapiens_hsa049170.67044223
77Amphetamine addiction_Homo sapiens_hsa050310.66110499
78ABC transporters_Homo sapiens_hsa020100.65495656
79Steroid biosynthesis_Homo sapiens_hsa001000.64961916
80Hepatitis C_Homo sapiens_hsa051600.64592536
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.64406922
82Renal cell carcinoma_Homo sapiens_hsa052110.62965713
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.62217334
84Notch signaling pathway_Homo sapiens_hsa043300.62057424
85mRNA surveillance pathway_Homo sapiens_hsa030150.61831401
86Tryptophan metabolism_Homo sapiens_hsa003800.61268371
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60605468
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.59463310
89Malaria_Homo sapiens_hsa051440.58905820
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.58626199
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58014889
92Olfactory transduction_Homo sapiens_hsa047400.57786050
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55798977
94Calcium signaling pathway_Homo sapiens_hsa040200.55300491
95Prostate cancer_Homo sapiens_hsa052150.55258516
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53102545
97Ras signaling pathway_Homo sapiens_hsa040140.52510169
98VEGF signaling pathway_Homo sapiens_hsa043700.51755845
99Endometrial cancer_Homo sapiens_hsa052130.51538733
100Leishmaniasis_Homo sapiens_hsa051400.50329399

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