ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sodium-independent organic anion transport (GO:0043252)	6.65125137
2	neuron fate determination (GO:0048664)	6.44197731
3	snRNA transcription (GO:0009301)	5.94859729
4	regulation of transmission of nerve impulse (GO:0051969)	5.79633235
5	aggressive behavior (GO:0002118)	5.63275168
6	cell proliferation involved in metanephros development (GO:0072203)	5.24778199
7	alkaloid metabolic process (GO:0009820)	5.18982685
8	regulation of female receptivity (GO:0045924)	5.11737091
9	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.82493446
10	inositol metabolic process (GO:0006020)	4.79690048
11	cellular response to cholesterol (GO:0071397)	4.78430903
12	cellular response to ethanol (GO:0071361)	4.64143121
13	I-kappaB phosphorylation (GO:0007252)	4.46920073
14	microtubule severing (GO:0051013)	4.45782618
15	positive regulation of epidermal cell differentiation (GO:0045606)	4.42588251
16	pyrimidine nucleotide catabolic process (GO:0006244)	4.41955018
17	cell proliferation involved in kidney development (GO:0072111)	4.40302406
18	sequestering of actin monomers (GO:0042989)	4.36787943
19	female mating behavior (GO:0060180)	4.21821318
20	positive regulation by symbiont of host defense response (GO:0052509)	4.21248913
21	modulation by symbiont of host defense response (GO:0052031)	4.21248913
22	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	4.21248913
23	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	4.21248913
24	positive regulation by organism of defense response of other organism involved in symbiotic interact	4.21248913
25	modulation by symbiont of host immune response (GO:0052553)	4.21248913
26	DNA topological change (GO:0006265)	4.17919430
27	NIK/NF-kappaB signaling (GO:0038061)	4.14362799
28	peristalsis (GO:0030432)	4.11647185
29	regulation of necroptotic process (GO:0060544)	4.10401080
30	regulation of mammary gland epithelial cell proliferation (GO:0033599)	4.09770827
31	maternal behavior (GO:0042711)	4.04340918
32	sulfation (GO:0051923)	4.03592965
33	nucleotide salvage (GO:0043173)	3.98946905
34	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.98807457
35	detection of molecule of bacterial origin (GO:0032490)	3.94133881
36	grooming behavior (GO:0007625)	3.88536676
37	glucocorticoid receptor signaling pathway (GO:0042921)	3.82730006
38	negative regulation of necroptotic process (GO:0060546)	3.77080438
39	somite development (GO:0061053)	3.68393556
40	neural tube formation (GO:0001841)	3.65799895
41	neuron fate specification (GO:0048665)	3.64506629
42	NAD biosynthetic process (GO:0009435)	3.62433364
43	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	3.58436122
44	negative regulation of interleukin-17 production (GO:0032700)	3.57326085
45	parental behavior (GO:0060746)	3.56984519
46	positive regulation of amino acid transport (GO:0051957)	3.53938324
47	response to cholesterol (GO:0070723)	3.52141785
48	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.51647054
49	cellular response to sterol (GO:0036315)	3.48914166
50	protein kinase C signaling (GO:0070528)	3.41750799
51	monoubiquitinated protein deubiquitination (GO:0035520)	3.38906348
52	behavioral response to nicotine (GO:0035095)	3.37645750
53	neurotransmitter-gated ion channel clustering (GO:0072578)	3.37372426
54	negative regulation of interleukin-12 production (GO:0032695)	3.37267909
55	post-anal tail morphogenesis (GO:0036342)	3.34739484
56	renal system development (GO:0072001)	3.30134612
57	hyperosmotic salinity response (GO:0042538)	3.27622903
58	positive regulation of T cell cytokine production (GO:0002726)	3.25641077
59	positive regulation of systemic arterial blood pressure (GO:0003084)	3.19711671
60	cellular anion homeostasis (GO:0030002)	3.19226765
61	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.19024492
62	positive regulation of RNA splicing (GO:0033120)	3.16459814
63	fusion of sperm to egg plasma membrane (GO:0007342)	3.15983770
64	regulation of triglyceride biosynthetic process (GO:0010866)	3.15022090
65	regulation of DNA damage checkpoint (GO:2000001)	3.13511664
66	protein prenylation (GO:0018342)	3.13373192
67	prenylation (GO:0097354)	3.13373192
68	thrombin receptor signaling pathway (GO:0070493)	3.13108393
69	response to host immune response (GO:0052572)	3.12442487
70	response to immune response of other organism involved in symbiotic interaction (GO:0052564)	3.12442487
71	hemoglobin metabolic process (GO:0020027)	3.11559163
72	negative regulation of defense response to virus (GO:0050687)	3.05466644
73	endosome to lysosome transport (GO:0008333)	3.05435937
74	layer formation in cerebral cortex (GO:0021819)	2.98329969
75	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.95563376
76	actin nucleation (GO:0045010)	2.95219651
77	corticosteroid receptor signaling pathway (GO:0031958)	2.92159021
78	negative regulation of necrotic cell death (GO:0060547)	2.89906326
79	embryonic heart tube development (GO:0035050)	2.85657570
80	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.85613641
81	pyridine nucleotide biosynthetic process (GO:0019363)	2.85613641
82	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	2.81032198
83	organic cation transport (GO:0015695)	2.80364160
84	response to sterol (GO:0036314)	2.78515679
85	response to defenses of other organism involved in symbiotic interaction (GO:0052173)	2.78124897
86	response to host (GO:0075136)	2.78124897
87	response to host defenses (GO:0052200)	2.78124897
88	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.77884650
89	embryonic camera-type eye development (GO:0031076)	2.77657467
90	positive regulation of epidermis development (GO:0045684)	2.74291543
91	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.73669933
92	negative regulation of neurological system process (GO:0031645)	2.73534819
93	neuron remodeling (GO:0016322)	2.71273364
94	mesonephros development (GO:0001823)	2.70731129
95	dendritic spine morphogenesis (GO:0060997)	2.70166839
96	auditory behavior (GO:0031223)	2.66935327
97	cholesterol catabolic process (GO:0006707)	2.66583491
98	sterol catabolic process (GO:0016127)	2.66583491
99	protein import into peroxisome matrix (GO:0016558)	2.64303047
100	regulation of histone H3-K9 methylation (GO:0051570)	2.61314225

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.18118679
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	5.00965854
3	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	4.02851835
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.17947864
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.62156255
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.51444468
7	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.44656774
8	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.44656774
9	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.44656774
10	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.33729352
11	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.20223738
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	12.5182550
13	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.96743818
14	AR_21572438_ChIP-Seq_LNCaP_Human	1.94441283
15	SCL_19346495_ChIP-Seq_HPC-7_Human	1.62991147
16	TP53_22127205_ChIP-Seq_IMR90_Human	1.60752131
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.57081242
18	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.56481545
19	MYC_22102868_ChIP-Seq_BL_Human	1.50968778
20	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.49017728
21	RXR_22108803_ChIP-Seq_LS180_Human	1.44404476
22	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.43559506
23	VDR_21846776_ChIP-Seq_THP-1_Human	1.42940043
24	VDR_24763502_ChIP-Seq_THP-1_Human	1.41283603
25	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.35633404
26	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.35261585
27	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.32992364
28	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.31749814
29	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.29764423
30	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.28527948
31	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.24211923
32	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.21445172
33	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.20970046
34	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.20815104
35	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.19101458
36	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.18384760
37	VDR_24787735_ChIP-Seq_THP-1_Human	1.17949551
38	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.17944708
39	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.16345519
40	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.14582331
41	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.13711765
42	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.11648380
43	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.09883993
44	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.09728877
45	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.09403139
46	SPI1_23127762_ChIP-Seq_K562_Human	1.09246350
47	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.08527285
48	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.00232282
49	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.97410581
50	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.95826640
51	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.94572698
52	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.94331931
53	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.93527936
54	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.91523664
55	TCF7_22412390_ChIP-Seq_EML_Mouse	0.90441811
56	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.90172981
57	MYB_26560356_Chip-Seq_TH2_Human	0.89028588
58	* KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.86902229
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.84886310
60	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.84823675
61	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.84506952
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.84506952
63	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.84231346
64	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.83959657
65	MAF_26560356_Chip-Seq_TH2_Human	0.83719397
66	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.83694248
67	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.83327277
68	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.82815836
69	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.81601477
70	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.79888481
71	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.78475321
72	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.78015239
73	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.76219467
74	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.75316414
75	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.74023720
76	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.72688252
77	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.71351306
78	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.71237491
79	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.70471683
80	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.70260861
81	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.69954082
82	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.69898234
83	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.69220884
84	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.68662455
85	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	0.67932953
86	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.67875225
87	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.67424183
88	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.67327292
89	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.67027611
90	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.66791261
91	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.66394144
92	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.65615476
93	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	0.65435128
94	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.64960203
95	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.64677053
96	RUNX_20019798_ChIP-Seq_JUKART_Human	0.64564674
97	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.64164620
98	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.63445880
99	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.63140540
100	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.62003579

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002638_abnormal_pupillary_reflex	5.33889866
2	MP0005645_abnormal_hypothalamus_physiol	4.83844632
3	MP0000383_abnormal_hair_follicle	3.68509065
4	MP0005187_abnormal_penis_morphology	3.07036069
5	MP0010307_abnormal_tumor_latency	3.04475023
6	MP0000538_abnormal_urinary_bladder	2.88183745
7	MP0010386_abnormal_urinary_bladder	2.85221709
8	MP0008057_abnormal_DNA_replication	2.83009999
9	MP0002089_abnormal_postnatal_growth/wei	2.79670349
10	MP0003122_maternal_imprinting	2.73462074
11	MP0004134_abnormal_chest_morphology	2.58790784
12	MP0003183_abnormal_peptide_metabolism	2.31012499
13	MP0002396_abnormal_hematopoietic_system	2.18856529
14	MP0010678_abnormal_skin_adnexa	2.08894392
15	MP0005503_abnormal_tendon_morphology	2.08216732
16	MP0003111_abnormal_nucleus_morphology	1.87602178
17	MP0002928_abnormal_bile_duct	1.84120242
18	MP0003252_abnormal_bile_duct	1.79116050
19	MP0003959_abnormal_lean_body	1.78910292
20	MP0000534_abnormal_ureter_morphology	1.76025620
21	MP0005058_abnormal_lysosome_morphology	1.75485956
22	MP0003868_abnormal_feces_composition	1.74325710
23	MP0000003_abnormal_adipose_tissue	1.73255773
24	MP0002932_abnormal_joint_morphology	1.57464971
25	MP0001853_heart_inflammation	1.56707046
26	MP0003705_abnormal_hypodermis_morpholog	1.52994585
27	MP0000733_abnormal_muscle_development	1.52545802
28	MP0002108_abnormal_muscle_morphology	1.47150230
29	MP0003172_abnormal_lysosome_physiology	1.40470005
30	MP0005220_abnormal_exocrine_pancreas	1.40259536
31	MP0003646_muscle_fatigue	1.39377177
32	MP0003283_abnormal_digestive_organ	1.39367119
33	MP0003123_paternal_imprinting	1.36463255
34	MP0005397_hematopoietic_system_phenotyp	1.31133326
35	MP0001545_abnormal_hematopoietic_system	1.31133326
36	MP0001968_abnormal_touch/_nociception	1.30395173
37	MP0004142_abnormal_muscle_tone	1.29690689
38	MP0003303_peritoneal_inflammation	1.20444370
39	MP0002405_respiratory_system_inflammati	1.19448434
40	MP0003121_genomic_imprinting	1.18691912
41	MP0002163_abnormal_gland_morphology	1.15598135
42	MP0004381_abnormal_hair_follicle	1.13673821
43	MP0005076_abnormal_cell_differentiation	1.13362230
44	MP0002938_white_spotting	1.12679101
45	MP0004185_abnormal_adipocyte_glucose	1.10328720
46	MP0009785_altered_susceptibility_to	1.10323149
47	MP0000639_abnormal_adrenal_gland	1.04957239
48	MP0004808_abnormal_hematopoietic_stem	1.04261838
49	MP0002095_abnormal_skin_pigmentation	1.03634720
50	MP0003195_calcinosis	1.03248881
51	MP0002735_abnormal_chemical_nociception	1.02449913
52	MP0002822_catalepsy	1.02394430
53	MP0001835_abnormal_antigen_presentation	1.02004083
54	MP0009764_decreased_sensitivity_to	1.01546471
55	MP0003828_pulmonary_edema	0.98826208
56	MP0000647_abnormal_sebaceous_gland	0.98518540
57	MP0009115_abnormal_fat_cell	0.98383733
58	MP0002098_abnormal_vibrissa_morphology	0.95679136
59	MP0005025_abnormal_response_to	0.95071113
60	MP0001915_intracranial_hemorrhage	0.94450518
61	MP0005375_adipose_tissue_phenotype	0.93161230
62	MP0001270_distended_abdomen	0.91693357
63	MP0002114_abnormal_axial_skeleton	0.91572879
64	MP0001188_hyperpigmentation	0.89871767
65	MP0010155_abnormal_intestine_physiology	0.86003263
66	MP0000516_abnormal_urinary_system	0.82966222
67	MP0005367_renal/urinary_system_phenotyp	0.82966222
68	MP0000490_abnormal_crypts_of	0.81612812
69	MP0004270_analgesia	0.81076702
70	MP0000428_abnormal_craniofacial_morphol	0.80098077
71	MP0002168_other_aberrant_phenotype	0.79518129
72	MP0000371_diluted_coat_color	0.78043091
73	MP0009697_abnormal_copulation	0.71854523
74	MP0002736_abnormal_nociception_after	0.71149753
75	MP0005000_abnormal_immune_tolerance	0.69296574
76	MP0005621_abnormal_cell_physiology	0.68987564
77	MP0002277_abnormal_respiratory_mucosa	0.68811553
78	MP0001800_abnormal_humoral_immune	0.68367045
79	MP0002419_abnormal_innate_immunity	0.67531516
80	MP0001905_abnormal_dopamine_level	0.66865543
81	MP0003632_abnormal_nervous_system	0.64294327
82	MP0002723_abnormal_immune_serum	0.64263603
83	MP0002722_abnormal_immune_system	0.63728700
84	MP0005369_muscle_phenotype	0.62914231
85	MP0004233_abnormal_muscle_weight	0.60592407
86	MP0009278_abnormal_bone_marrow	0.60159973
87	MP0008469_abnormal_protein_level	0.59988675
88	MP0003724_increased_susceptibility_to	0.59924714
89	MP0005257_abnormal_intraocular_pressure	0.59916703
90	MP0009765_abnormal_xenobiotic_induced	0.59915259
91	MP0002106_abnormal_muscle_physiology	0.59588764
92	MP0002420_abnormal_adaptive_immunity	0.58719688
93	MP0005334_abnormal_fat_pad	0.58495992
94	MP0001819_abnormal_immune_cell	0.57965426
95	MP0005451_abnormal_body_composition	0.57432478
96	MP0002249_abnormal_larynx_morphology	0.57368652
97	MP0000759_abnormal_skeletal_muscle	0.56743036
98	MP0003115_abnormal_respiratory_system	0.55993211
99	MP0003866_abnormal_defecation	0.55746701
100	MP0003300_gastrointestinal_ulcer	0.54699827

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deformed sella turcica (HP:0002681)	5.14512944
2	Broad face (HP:0000283)	4.82306143
3	Abnormality of the sella turcica (HP:0002679)	4.72952415
4	Neoplasm of the heart (HP:0100544)	4.59798550
5	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	4.57683897
6	Short 4th metacarpal (HP:0010044)	4.57683897
7	Spontaneous abortion (HP:0005268)	4.05345983
8	Supernumerary bones of the axial skeleton (HP:0009144)	3.93413723
9	Large earlobe (HP:0009748)	3.92317767
10	Abnormality of the parietal bone (HP:0002696)	3.74035020
11	Poor eye contact (HP:0000817)	3.73643419
12	Abnormality of the nasal septum (HP:0000419)	3.66389410
13	Thrombocytosis (HP:0001894)	3.58584775
14	Vertebral arch anomaly (HP:0008438)	3.56740361
15	Abnormality of liposaccharide metabolism (HP:0010968)	3.56528704
16	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.56528704
17	Abnormality of glycolipid metabolism (HP:0010969)	3.56528704
18	Supernumerary ribs (HP:0005815)	3.49311908
19	Down-sloping shoulders (HP:0200021)	3.19514148
20	Short phalanx of the thumb (HP:0009660)	3.16823154
21	Split foot (HP:0001839)	3.13918225
22	Cutaneous melanoma (HP:0012056)	3.10031152
23	Abnormality of the 4th metacarpal (HP:0010012)	3.07289792
24	Medulloblastoma (HP:0002885)	3.06641091
25	Abnormality of the lumbar spine (HP:0100712)	3.05351458
26	Diastasis recti (HP:0001540)	3.04672305
27	Depressed nasal tip (HP:0000437)	2.98090361
28	Urethral obstruction (HP:0000796)	2.98077451
29	Flat occiput (HP:0005469)	2.91976066
30	Hemiplegia (HP:0002301)	2.84832193
31	Thoracolumbar scoliosis (HP:0002944)	2.80881681
32	Flat acetabular roof (HP:0003180)	2.75909979
33	Abnormal social behavior (HP:0012433)	2.69377337
34	Impaired social interactions (HP:0000735)	2.69377337
35	Abnormality of the distal phalanx of the thumb (HP:0009617)	2.66648370
36	11 pairs of ribs (HP:0000878)	2.62680132
37	Short nail (HP:0001799)	2.61026426
38	Abnormal number of incisors (HP:0011064)	2.58831232
39	Milia (HP:0001056)	2.56441859
40	Hyperventilation (HP:0002883)	2.51761697
41	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.50771430
42	Broad ribs (HP:0000885)	2.42851462
43	Neoplasm of the oral cavity (HP:0100649)	2.38122312
44	Glioma (HP:0009733)	2.35428800
45	Gingival bleeding (HP:0000225)	2.34924166
46	Nonimmune hydrops fetalis (HP:0001790)	2.32169891
47	Abnormal ossification of hand bones (HP:0005921)	2.29848252
48	Vitreoretinal degeneration (HP:0000655)	2.26970496
49	Hemiparesis (HP:0001269)	2.26949056
50	Deep venous thrombosis (HP:0002625)	2.26262110
51	Subacute progressive viral hepatitis (HP:0006572)	2.24216230
52	Thoracic kyphosis (HP:0002942)	2.23897279
53	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.23201333
54	Pigmentary retinal degeneration (HP:0001146)	2.19987997
55	Abnormality of polysaccharide metabolism (HP:0011012)	2.19864001
56	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.19864001
57	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.19864001
58	Midline defect of the nose (HP:0004122)	2.18935846
59	Viral hepatitis (HP:0006562)	2.17559658
60	Trigonocephaly (HP:0000243)	2.16718536
61	Arterial thrombosis (HP:0004420)	2.10858145
62	Flared iliac wings (HP:0002869)	2.10560321
63	Median cleft lip (HP:0000161)	2.10206906
64	Progressive microcephaly (HP:0000253)	2.09367092
65	Severe global developmental delay (HP:0011344)	2.09088105
66	Fibular hypoplasia (HP:0003038)	2.08779794
67	Dysostosis multiplex (HP:0000943)	2.08325266
68	Clumsiness (HP:0002312)	2.08120605
69	Macroorchidism (HP:0000053)	2.06932263
70	Abnormal hand bone ossification (HP:0010660)	2.03805150
71	Meningioma (HP:0002858)	2.03475579
72	Long eyelashes (HP:0000527)	2.03246578
73	Wide nose (HP:0000445)	2.03000304
74	Thrombophlebitis (HP:0004418)	2.01767149
75	J-shaped sella turcica (HP:0002680)	2.01721326
76	Bilateral microphthalmos (HP:0007633)	1.99218412
77	Acanthocytosis (HP:0001927)	1.98617178
78	Dislocated radial head (HP:0003083)	1.98301302
79	Palpebral edema (HP:0100540)	1.97770583
80	Absent speech (HP:0001344)	1.97355527
81	Protruding tongue (HP:0010808)	1.92791576
82	Periodontitis (HP:0000704)	1.86753937
83	Recurrent cutaneous fungal infections (HP:0011370)	1.86391714
84	Chronic mucocutaneous candidiasis (HP:0002728)	1.86391714
85	Abnormality of the periventricular white matter (HP:0002518)	1.84749203
86	Skin pits (HP:0100276)	1.83996767
87	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.83131968
88	Poikilocytosis (HP:0004447)	1.81980082
89	Portal hypertension (HP:0001409)	1.81603087
90	Cerebellar dysplasia (HP:0007033)	1.80209615
91	Non-midline cleft lip (HP:0100335)	1.78077997
92	Chest pain (HP:0100749)	1.77289132
93	Craniofacial hyperostosis (HP:0004493)	1.76650497
94	Hepatoblastoma (HP:0002884)	1.76504167
95	Beaking of vertebral bodies (HP:0004568)	1.75541738
96	Submucous cleft hard palate (HP:0000176)	1.73213966
97	Increased serum ferritin (HP:0003281)	1.71091325
98	Epistaxis (HP:0000421)	1.70350907
99	Abnormality of the thoracic spine (HP:0100711)	1.70141615
100	Abnormality of the hepatic vasculature (HP:0006707)	1.70130671

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	6.25991444
2	SCYL2	5.50621968
3	STK4	3.48079512
4	TLK1	3.32899778
5	NUAK1	2.47826148
6	CAMK1D	2.35223371
7	MAP3K8	2.29097774
8	KDR	2.25419201
9	CDK12	2.20438653
10	MAP2K3	2.19820359
11	BRD4	1.92733485
12	IKBKE	1.91732541
13	ZAK	1.83472342
14	FRK	1.78313902
15	CAMK1G	1.73458503
16	SGK2	1.73075531
17	BLK	1.70634929
18	DYRK3	1.60299870
19	PRPF4B	1.54602354
20	IRAK4	1.34349200
21	MAP3K3	1.30886893
22	BCKDK	1.28390413
23	SGK3	1.27359664
24	SGK494	1.24492390
25	SGK223	1.24492390
26	TAOK3	1.18804056
27	MAP3K1	1.15726820
28	CASK	1.11185726
29	LATS1	1.11010639
30	MAP3K14	1.08451637
31	AKT3	0.99451676
32	WNK1	0.98688066
33	HIPK2	0.96464768
34	MAP3K13	0.94025214
35	PRKAA1	0.93673895
36	CDC42BPA	0.91964202
37	MAP3K7	0.86520876
38	RPS6KB2	0.86393311
39	SGK1	0.85544966
40	TBK1	0.81655463
41	RPS6KA4	0.81386117
42	SIK2	0.78807706
43	FGFR3	0.77573547
44	CSK	0.75285830
45	RPS6KA2	0.74573944
46	TRIB3	0.73620886
47	CHUK	0.72811428
48	MAP2K6	0.72451990
49	IRAK2	0.70814578
50	EEF2K	0.69570849
51	CAMKK2	0.68365999
52	MATK	0.67717577
53	CSF1R	0.63923137
54	AURKB	0.63753371
55	MTOR	0.61815889
56	PRKAA2	0.61797207
57	IRAK1	0.61580458
58	PRKG1	0.60354674
59	LRRK2	0.58649623
60	CDK4	0.57512134
61	FGFR4	0.57461902
62	ICK	0.56271680
63	FGR	0.55149430
64	RPS6KA5	0.53919350
65	GRK6	0.53755552
66	CAMK4	0.52510937
67	TAF1	0.51572472
68	STK16	0.51080743
69	ATR	0.48106673
70	ADRBK2	0.47892443
71	TIE1	0.47663730
72	MAPK3	0.47134171
73	PRKCQ	0.47125262
74	TNIK	0.45562664
75	PKN2	0.43732139
76	STK38	0.42659845
77	ADRBK1	0.41655400
78	FGFR2	0.41275121
79	RPS6KA6	0.41051570
80	AKT1	0.40922186
81	GRK7	0.40415356
82	BMPR1B	0.39184058
83	CAMKK1	0.39062089
84	TRPM7	0.37502093
85	SYK	0.37198835
86	MAP3K2	0.36954843
87	CDK2	0.36792023
88	AURKA	0.36773026
89	FES	0.34975492
90	TESK2	0.34759135
91	RPS6KC1	0.32784413
92	RPS6KL1	0.32784413
93	TYRO3	0.32649902
94	GSK3A	0.32625833
95	OBSCN	0.32072768
96	STK11	0.31692959
97	CDK3	0.30693660
98	TTN	0.29958481
99	MAPKAPK3	0.29556718
100	ZAP70	0.29439399

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	4.58682038
2	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.50098036
3	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	3.01625013
4	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.94001144
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.59132887
6	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	2.19128564
7	Fatty acid elongation_Homo sapiens_hsa00062	2.05530466
8	Alcoholism_Homo sapiens_hsa05034	1.97227755
9	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.89761209
10	Malaria_Homo sapiens_hsa05144	1.70690429
11	Leishmaniasis_Homo sapiens_hsa05140	1.57697453
12	Other glycan degradation_Homo sapiens_hsa00511	1.55504400
13	Basal cell carcinoma_Homo sapiens_hsa05217	1.55384561
14	Notch signaling pathway_Homo sapiens_hsa04330	1.50507720
15	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.46223980
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.33972087
17	Platelet activation_Homo sapiens_hsa04611	1.32881415
18	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.29955528
19	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.27034684
20	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.26349781
21	Viral carcinogenesis_Homo sapiens_hsa05203	1.14991093
22	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.12424825
23	Complement and coagulation cascades_Homo sapiens_hsa04610	1.10826049
24	Calcium signaling pathway_Homo sapiens_hsa04020	1.06104406
25	Toxoplasmosis_Homo sapiens_hsa05145	1.05268673
26	Measles_Homo sapiens_hsa05162	1.04571455
27	Lysine degradation_Homo sapiens_hsa00310	1.04486602
28	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.02904936
29	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.02688523
30	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.01463386
31	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.97694526
32	Steroid biosynthesis_Homo sapiens_hsa00100	0.97590987
33	Small cell lung cancer_Homo sapiens_hsa05222	0.97454998
34	Gastric acid secretion_Homo sapiens_hsa04971	0.94121961
35	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.92427021
36	MicroRNAs in cancer_Homo sapiens_hsa05206	0.88542907
37	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.86324790
38	Herpes simplex infection_Homo sapiens_hsa05168	0.86289619
39	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.84420609
40	Salmonella infection_Homo sapiens_hsa05132	0.83548530
41	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.83344097
42	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.82681012
43	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.82035715
44	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.81890520
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.81658706
46	Insulin resistance_Homo sapiens_hsa04931	0.81490735
47	Influenza A_Homo sapiens_hsa05164	0.79241495
48	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.78896014
49	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.77309264
50	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.77231665
51	Prostate cancer_Homo sapiens_hsa05215	0.76269595
52	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.74804011
53	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.74532181
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.74368373
55	HTLV-I infection_Homo sapiens_hsa05166	0.70009319
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69813012
57	Gap junction_Homo sapiens_hsa04540	0.69493014
58	GnRH signaling pathway_Homo sapiens_hsa04912	0.69464579
59	cAMP signaling pathway_Homo sapiens_hsa04024	0.69074099
60	TNF signaling pathway_Homo sapiens_hsa04668	0.68564886
61	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.67774979
62	Non-small cell lung cancer_Homo sapiens_hsa05223	0.67448871
63	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.66922948
64	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66708840
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.66691221
66	Long-term potentiation_Homo sapiens_hsa04720	0.66610532
67	Taste transduction_Homo sapiens_hsa04742	0.64901428
68	Tuberculosis_Homo sapiens_hsa05152	0.63736781
69	Cholinergic synapse_Homo sapiens_hsa04725	0.63516982
70	Renin secretion_Homo sapiens_hsa04924	0.63186952
71	Allograft rejection_Homo sapiens_hsa05330	0.62492739
72	Acute myeloid leukemia_Homo sapiens_hsa05221	0.60933011
73	ErbB signaling pathway_Homo sapiens_hsa04012	0.59871946
74	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.59600199
75	Proteoglycans in cancer_Homo sapiens_hsa05205	0.59307108
76	Oocyte meiosis_Homo sapiens_hsa04114	0.59306242
77	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.58581980
78	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.57428413
79	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.57101342
80	Osteoclast differentiation_Homo sapiens_hsa04380	0.55851154
81	Pancreatic cancer_Homo sapiens_hsa05212	0.53388061
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.53025953
83	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52005547
84	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.51998900
85	Focal adhesion_Homo sapiens_hsa04510	0.51902503
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51650505
87	Phagosome_Homo sapiens_hsa04145	0.51594011
88	Primary immunodeficiency_Homo sapiens_hsa05340	0.51348690
89	African trypanosomiasis_Homo sapiens_hsa05143	0.51155712
90	MAPK signaling pathway_Homo sapiens_hsa04010	0.47821354
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.47473856
92	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.47278580
93	Pertussis_Homo sapiens_hsa05133	0.47079158
94	Type II diabetes mellitus_Homo sapiens_hsa04930	0.46897071
95	Glioma_Homo sapiens_hsa05214	0.46529947
96	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.46438964
97	Cocaine addiction_Homo sapiens_hsa05030	0.44563448
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.44124601
99	Cell cycle_Homo sapiens_hsa04110	0.41188512
100	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.41051434

SH3GL1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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