SH3GL1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to muramyl dipeptide (GO:0032495)5.07019185
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.04498989
3negative regulation of cell killing (GO:0031342)5.04498989
4positive regulation of gamma-delta T cell activation (GO:0046645)4.83975423
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.68298336
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.49227644
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.43176974
8negative regulation of erythrocyte differentiation (GO:0045647)4.29772832
9thymic T cell selection (GO:0045061)4.26009523
10negative thymic T cell selection (GO:0045060)4.24987666
11antigen processing and presentation of endogenous antigen (GO:0019883)4.20125282
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.15158025
13positive thymic T cell selection (GO:0045059)4.12107825
14negative regulation of type 2 immune response (GO:0002829)4.06739036
15negative T cell selection (GO:0043383)3.92030451
16response to peptidoglycan (GO:0032494)3.89786690
17Arp2/3 complex-mediated actin nucleation (GO:0034314)3.88096583
18regulation of B cell receptor signaling pathway (GO:0050855)3.86462521
19response to interleukin-15 (GO:0070672)3.83012943
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.81650926
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.81650926
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.81650926
23modulation by symbiont of host immune response (GO:0052553)3.81650926
24positive regulation by symbiont of host defense response (GO:0052509)3.81650926
25modulation by symbiont of host defense response (GO:0052031)3.81650926
26negative regulation of granulocyte differentiation (GO:0030853)3.80011395
27regulation of memory T cell differentiation (GO:0043380)3.79795132
28positive regulation of natural killer cell differentiation (GO:0032825)3.78969890
29tolerance induction (GO:0002507)3.77725979
30T cell selection (GO:0045058)3.67427424
31regulation of gamma-delta T cell activation (GO:0046643)3.65357519
32regulation of gamma-delta T cell differentiation (GO:0045586)3.64629253
33mannose metabolic process (GO:0006013)3.64485031
34negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.57222740
35cellular response to interleukin-15 (GO:0071350)3.49189213
36leukocyte aggregation (GO:0070486)3.39242341
37NIK/NF-kappaB signaling (GO:0038061)3.31088068
38regulation of interferon-beta biosynthetic process (GO:0045357)3.29271480
39macrophage activation involved in immune response (GO:0002281)3.23279670
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.21745119
41signal complex assembly (GO:0007172)3.21361855
42lipopolysaccharide-mediated signaling pathway (GO:0031663)3.18687327
43neutrophil activation involved in immune response (GO:0002283)3.14205295
44actin nucleation (GO:0045010)3.11698328
45positive T cell selection (GO:0043368)3.09828976
46regulation of T cell tolerance induction (GO:0002664)3.09555393
47negative regulation of T cell mediated immunity (GO:0002710)3.07748876
48B cell receptor signaling pathway (GO:0050853)3.05237818
49neutrophil activation (GO:0042119)3.00456913
50detection of bacterium (GO:0016045)2.99921611
51detection of other organism (GO:0098543)2.97846069
52regulation of alpha-beta T cell proliferation (GO:0046640)2.96785526
53negative regulation of innate immune response (GO:0045824)2.95141543
54positive regulation of interleukin-17 production (GO:0032740)2.90839858
55germinal center formation (GO:0002467)2.88765998
56positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87450469
57positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85263020
58positive regulation of cholesterol efflux (GO:0010875)2.85091438
59immunoglobulin mediated immune response (GO:0016064)2.84595115
60activation of JUN kinase activity (GO:0007257)2.84536049
61positive regulation of T cell mediated cytotoxicity (GO:0001916)2.83128146
62regulation of type 2 immune response (GO:0002828)2.82212156
63regulation of T cell mediated cytotoxicity (GO:0001914)2.81361488
64granulocyte activation (GO:0036230)2.81199632
65negative regulation of leukocyte mediated immunity (GO:0002704)2.79359636
66negative regulation of bone resorption (GO:0045779)2.78924779
67regulation of tolerance induction (GO:0002643)2.78662806
68regulation of granulocyte differentiation (GO:0030852)2.73922301
69positive regulation of tolerance induction (GO:0002645)2.73491866
70regulation of B cell differentiation (GO:0045577)2.72473068
71detection of external biotic stimulus (GO:0098581)2.71065389
72regulation of MHC class I biosynthetic process (GO:0045343)2.69536827
73positive regulation of Rap GTPase activity (GO:0032854)2.68295392
74negative regulation of interleukin-6 production (GO:0032715)2.68229819
75regulation of natural killer cell differentiation (GO:0032823)2.67813699
76detection of molecule of bacterial origin (GO:0032490)2.67753589
77response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.67697703
78response to host immune response (GO:0052572)2.67697703
79positive regulation of B cell differentiation (GO:0045579)2.62357100
80response to type I interferon (GO:0034340)2.61529292
81negative regulation of phagocytosis (GO:0050765)2.60906592
82type I interferon signaling pathway (GO:0060337)2.60809853
83cellular response to type I interferon (GO:0071357)2.60809853
84T-helper cell differentiation (GO:0042093)2.52899810
85CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.52899810
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.50547967
87response to host (GO:0075136)2.50547967
88response to host defenses (GO:0052200)2.50547967
89negative regulation of stress fiber assembly (GO:0051497)2.50383894
90regulation of T-helper 2 cell differentiation (GO:0045628)2.50223007
91positive regulation of alpha-beta T cell proliferation (GO:0046641)2.50008926
923-UTR-mediated mRNA stabilization (GO:0070935)2.49980882
93regulation of chromatin binding (GO:0035561)2.43849365
94regulation of interleukin-13 production (GO:0032656)2.43453517
95B cell homeostasis (GO:0001782)2.41897796
96cellular extravasation (GO:0045123)2.41284205
97negative regulation of interleukin-12 production (GO:0032695)2.41216746
98positive regulation of natural killer cell activation (GO:0032816)2.41213499
99positive regulation of T cell differentiation in thymus (GO:0033089)2.38708807
100myeloid cell activation involved in immune response (GO:0002275)2.38481668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.72984819
2VDR_21846776_ChIP-Seq_THP-1_Human3.16499834
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.01055860
4MYC_22102868_ChIP-Seq_BL_Human2.87328118
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.59856497
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50790413
7TCF7_22412390_ChIP-Seq_EML_Mouse2.46261919
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.42830473
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.41339220
10VDR_24763502_ChIP-Seq_THP-1_Human2.38957872
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.38168123
12KDM2B_26808549_Chip-Seq_DND41_Human2.37104860
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.36720993
14LXR_22292898_ChIP-Seq_THP-1_Human2.29457251
15UTX_26944678_Chip-Seq_JUKART_Human2.28266983
16MAF_26560356_Chip-Seq_TH1_Human2.24504949
17RUNX_20019798_ChIP-Seq_JUKART_Human2.21077034
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18277743
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17913032
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14827891
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12285880
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07639541
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.06259675
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.04417238
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98494691
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94480925
27SCL_19346495_ChIP-Seq_HPC-7_Human1.93961090
28MAF_26560356_Chip-Seq_TH2_Human1.90918199
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.86499608
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85180235
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83962672
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83292475
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80508996
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77979794
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77878485
36RACK7_27058665_Chip-Seq_MCF-7_Human1.75702605
37MYB_26560356_Chip-Seq_TH2_Human1.75102853
38SPI1_23127762_ChIP-Seq_K562_Human1.74232713
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72508398
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.69464207
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68549600
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.66917746
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64627362
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61387585
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.57616423
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56923809
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.54211614
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.51849360
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51577427
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.50195483
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49425093
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47996625
53MYB_26560356_Chip-Seq_TH1_Human1.46101235
54SPI1_23547873_ChIP-Seq_NB4_Human1.45587000
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43904401
56BCL6_27268052_Chip-Seq_Bcells_Human1.43535255
57P68_20966046_ChIP-Seq_HELA_Human1.40978524
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35947414
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.32884061
60SMC4_20622854_ChIP-Seq_HELA_Human1.32837049
61BCOR_27268052_Chip-Seq_Bcells_Human1.32461324
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32400543
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32386925
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.32016728
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31747886
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31022838
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29461298
68KDM2B_26808549_Chip-Seq_K562_Human1.28349273
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28192778
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26345299
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26317454
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23365437
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23263126
74GATA3_27048872_Chip-Seq_THYMUS_Human1.22252219
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20634725
76PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17757027
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.16531278
78CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15204554
79NCOR1_26117541_ChIP-Seq_K562_Human1.14838192
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.14448239
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13975901
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.13648366
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13259513
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12845003
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11658786
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11456811
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09630282
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09521997
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08506204
90GATA1_22025678_ChIP-Seq_K562_Human1.05989053
91DROSHA_22980978_ChIP-Seq_HELA_Human1.04953909
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03968359
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02599624
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01949752
95VDR_24787735_ChIP-Seq_THP-1_Human1.01074299
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00892469
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.00216310
98SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99433677
99ERG_21242973_ChIP-ChIP_JURKAT_Human0.97505326
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97349194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.40745204
2MP0003724_increased_susceptibility_to3.63646307
3MP0003763_abnormal_thymus_physiology3.21095017
4MP0003303_peritoneal_inflammation3.18648723
5MP0005000_abnormal_immune_tolerance2.73082953
6MP0003191_abnormal_cellular_cholesterol2.69604548
7MP0001800_abnormal_humoral_immune2.55961193
8MP0003172_abnormal_lysosome_physiology2.55694423
9MP0005025_abnormal_response_to2.48639725
10MP0002419_abnormal_innate_immunity2.48173744
11MP0001835_abnormal_antigen_presentation2.40271445
12MP0009278_abnormal_bone_marrow2.36473210
13MP0002723_abnormal_immune_serum2.33777787
14MP0002933_joint_inflammation2.28174259
15MP0001790_abnormal_immune_system2.27805177
16MP0005387_immune_system_phenotype2.27805177
17MP0006082_CNS_inflammation2.26498625
18MP0001533_abnormal_skeleton_physiology2.25813434
19MP0003183_abnormal_peptide_metabolism2.25700218
20MP0005671_abnormal_response_to2.25432511
21MP0000685_abnormal_immune_system2.23629895
22MP0009785_altered_susceptibility_to2.23164898
23MP0004947_skin_inflammation2.23053692
24MP0002420_abnormal_adaptive_immunity2.21505640
25MP0001819_abnormal_immune_cell2.20882314
26MP0005058_abnormal_lysosome_morphology2.20561796
27MP0002452_abnormal_antigen_presenting2.08471823
28MP0010155_abnormal_intestine_physiology2.04971099
29MP0009333_abnormal_splenocyte_physiolog2.02321316
30MP0002405_respiratory_system_inflammati1.95766767
31MP0002148_abnormal_hypersensitivity_rea1.83104239
32MP0002398_abnormal_bone_marrow1.79874405
33MP0008260_abnormal_autophagy1.76800961
34MP0000716_abnormal_immune_system1.75144482
35MP0000703_abnormal_thymus_morphology1.73923385
36MP0005464_abnormal_platelet_physiology1.71285991
37MP0003300_gastrointestinal_ulcer1.62032445
38MP0005076_abnormal_cell_differentiation1.61972832
39MP0003828_pulmonary_edema1.61812814
40MP0002166_altered_tumor_susceptibility1.56630235
41MP0004381_abnormal_hair_follicle1.55961753
42MP0000858_altered_metastatic_potential1.54678471
43MP0002722_abnormal_immune_system1.50233455
44MP0004510_myositis1.48969451
45MP0001845_abnormal_inflammatory_respons1.48389173
46MP0002998_abnormal_bone_remodeling1.46256503
47MP0000689_abnormal_spleen_morphology1.42550699
48MP0002429_abnormal_blood_cell1.40786296
49MP0009840_abnormal_foam_cell1.40001939
50MP0009764_decreased_sensitivity_to1.38922637
51MP0003866_abnormal_defecation1.36260903
52MP0002009_preneoplasia1.34623477
53MP0005451_abnormal_body_composition1.33060258
54MP0002132_abnormal_respiratory_system1.32093196
55MP0001873_stomach_inflammation1.30781100
56MP0005397_hematopoietic_system_phenotyp1.30206853
57MP0001545_abnormal_hematopoietic_system1.30206853
58MP0004130_abnormal_muscle_cell1.29517289
59MP0005390_skeleton_phenotype1.28940910
60MP0001851_eye_inflammation1.26564958
61MP0008469_abnormal_protein_level1.23506272
62MP0003279_aneurysm1.21071296
63MP0003656_abnormal_erythrocyte_physiolo1.19770004
64MP0005377_hearing/vestibular/ear_phenot1.15331317
65MP0003878_abnormal_ear_physiology1.15331317
66MP0002396_abnormal_hematopoietic_system1.14842644
67MP0000465_gastrointestinal_hemorrhage1.07141343
68MP0000015_abnormal_ear_pigmentation1.03678224
69MP0003705_abnormal_hypodermis_morpholog0.98370032
70MP0008874_decreased_physiological_sensi0.94488756
71MP0005166_decreased_susceptibility_to0.94045312
72MP0001853_heart_inflammation0.93154977
73MP0002006_tumorigenesis0.90759746
74MP0004808_abnormal_hematopoietic_stem0.89728805
75MP0003453_abnormal_keratinocyte_physiol0.87326180
76MP0004883_abnormal_blood_vessel0.85927607
77MP0000249_abnormal_blood_vessel0.85482462
78MP0003075_altered_response_to0.82589579
79MP0003795_abnormal_bone_structure0.78882145
80MP0006138_congestive_heart_failure0.78224152
81MP0005310_abnormal_salivary_gland0.77882282
82MP0005375_adipose_tissue_phenotype0.77671379
83MP0002254_reproductive_system_inflammat0.74972541
84MP0000767_abnormal_smooth_muscle0.72737263
85MP0000604_amyloidosis0.72427356
86MP0000013_abnormal_adipose_tissue0.72289258
87MP0005167_abnormal_blood-brain_barrier0.71676514
88MP0005666_abnormal_adipose_tissue0.70278358
89MP0005075_abnormal_melanosome_morpholog0.70080367
90MP0000003_abnormal_adipose_tissue0.69866103
91MP0000371_diluted_coat_color0.69093123
92MP0003091_abnormal_cell_migration0.68849217
93MP0004185_abnormal_adipocyte_glucose0.68277964
94MP0009115_abnormal_fat_cell0.68251774
95MP0003329_amyloid_beta_deposits0.66077784
96MP0002138_abnormal_hepatobiliary_system0.65851071
97MP0009763_increased_sensitivity_to0.65374636
98MP0005164_abnormal_response_to0.64679643
99MP0001849_ear_inflammation0.64640729
100MP0001348_abnormal_lacrimal_gland0.62693323

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.80236022
2Spontaneous hematomas (HP:0007420)3.91778824
3Recurrent abscess formation (HP:0002722)3.77130879
4Myositis (HP:0100614)3.76024362
5Inflammation of the large intestine (HP:0002037)3.66440359
6Gastrointestinal inflammation (HP:0004386)3.64287004
7T lymphocytopenia (HP:0005403)3.60011289
8Elevated erythrocyte sedimentation rate (HP:0003565)3.57051229
9Recurrent bacterial skin infections (HP:0005406)3.53664599
10Colitis (HP:0002583)3.28050520
11Abnormality of macrophages (HP:0004311)3.27071446
12Orchitis (HP:0100796)3.23405078
13Gastrointestinal infarctions (HP:0005244)3.21486646
14Obstructive lung disease (HP:0006536)3.15788612
15Chronic obstructive pulmonary disease (HP:0006510)3.15788612
16J-shaped sella turcica (HP:0002680)3.13691143
17Recurrent fungal infections (HP:0002841)3.02273348
18Increased IgE level (HP:0003212)3.01467645
19Dysostosis multiplex (HP:0000943)3.00939547
20Abnormality of T cell number (HP:0011839)2.98946162
21Pustule (HP:0200039)2.87380286
22Retrobulbar optic neuritis (HP:0100654)2.85487590
23Optic neuritis (HP:0100653)2.85487590
24Granulocytopenia (HP:0001913)2.84778633
25Abnormality of glycolipid metabolism (HP:0010969)2.78857253
26Abnormality of liposaccharide metabolism (HP:0010968)2.78857253
27Abnormality of glycosphingolipid metabolism (HP:0004343)2.78857253
28Meningitis (HP:0001287)2.78127738
29Abnormality of polysaccharide metabolism (HP:0011012)2.70956475
30Abnormality of glycosaminoglycan metabolism (HP:0004371)2.70956475
31Abnormality of mucopolysaccharide metabolism (HP:0011020)2.70956475
32Urinary glycosaminoglycan excretion (HP:0003541)2.69734908
33Mucopolysacchariduria (HP:0008155)2.69734908
34Nasal polyposis (HP:0100582)2.67769903
35Encephalitis (HP:0002383)2.67591038
36Recurrent gram-negative bacterial infections (HP:0005420)2.66979732
37Slow saccadic eye movements (HP:0000514)2.64225681
38Increased cerebral lipofuscin (HP:0011813)2.60443743
39Increased IgM level (HP:0003496)2.58269536
40Obstructive sleep apnea (HP:0002870)2.54774242
41Epistaxis (HP:0000421)2.54356476
42Prolonged bleeding time (HP:0003010)2.54132434
43Chest pain (HP:0100749)2.53819985
44Abnormality of the nasal mucosa (HP:0000433)2.52806805
45Hemorrhage of the eye (HP:0011885)2.52007520
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.51339736
47Vasculitis (HP:0002633)2.50494744
48Mediastinal lymphadenopathy (HP:0100721)2.49736176
49Recurrent viral infections (HP:0004429)2.48546567
50Severe combined immunodeficiency (HP:0004430)2.46978410
51Gingival bleeding (HP:0000225)2.44464696
52Cellulitis (HP:0100658)2.43429184
53Recurrent skin infections (HP:0001581)2.36928493
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.36509841
55Panhypogammaglobulinemia (HP:0003139)2.35198949
56Abnormality of T cells (HP:0002843)2.32852925
57Chronic mucocutaneous candidiasis (HP:0002728)2.31226000
58Recurrent cutaneous fungal infections (HP:0011370)2.31226000
59Pulmonary embolism (HP:0002204)2.25492664
60Myopathic facies (HP:0002058)2.25319187
61Broad face (HP:0000283)2.24702435
62Papilloma (HP:0012740)2.24557454
63Verrucae (HP:0200043)2.24557454
64Abnormality of the fingertips (HP:0001211)2.21868054
65Gingivitis (HP:0000230)2.20550271
66Stomatitis (HP:0010280)2.19215571
67Eosinophilia (HP:0001880)2.19177811
68Agammaglobulinemia (HP:0004432)2.16699817
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15196886
70Pulmonary infiltrates (HP:0002113)2.15022998
71Urticaria (HP:0001025)2.13048183
72Easy fatigability (HP:0003388)2.11328533
73Increased serum ferritin (HP:0003281)2.11148055
74Cervical subluxation (HP:0003308)2.09884890
75Distal lower limb amyotrophy (HP:0008944)2.09510667
76Hypergammaglobulinemia (HP:0010702)2.08843432
77Leukocytosis (HP:0001974)2.08562524
78Thoracic kyphosis (HP:0002942)2.07992811
79Distal lower limb muscle weakness (HP:0009053)2.06473228
80Hypochromic anemia (HP:0001931)2.06180589
81Global brain atrophy (HP:0002283)2.05373933
82Hematochezia (HP:0002573)2.04106264
83Abnormality of eosinophils (HP:0001879)2.03428976
84Hepatosplenomegaly (HP:0001433)2.02404711
85Centrally nucleated skeletal muscle fibers (HP:0003687)2.02142441
86Ocular albinism (HP:0001107)1.99557229
87Joint stiffness (HP:0001387)1.97828845
88Keratoconjunctivitis sicca (HP:0001097)1.97729005
89Glomerulopathy (HP:0100820)1.97645147
90Polygenic inheritance (HP:0010982)1.97129470
91Deformed sella turcica (HP:0002681)1.96551772
92Sepsis (HP:0100806)1.96357129
93Keratoconjunctivitis (HP:0001096)1.94166631
94Systemic lupus erythematosus (HP:0002725)1.92824709
95Conical tooth (HP:0000698)1.92284476
96Stomach cancer (HP:0012126)1.91802040
97Asymmetric septal hypertrophy (HP:0001670)1.89938504
98Hypertriglyceridemia (HP:0002155)1.87634487
99B lymphocytopenia (HP:0010976)1.85466708
100Amyloidosis (HP:0011034)1.85181734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.20038782
2RIPK43.17018459
3MAP3K142.85732132
4MAP4K12.85465015
5PRPF4B2.80690869
6TRIB32.69701460
7IKBKE2.67566622
8TBK12.41805148
9TXK2.29240667
10MAP2K22.26823291
11MAP2K32.14051097
12GRK62.11114802
13SIK12.03164036
14TNK21.97709697
15IRAK41.83525588
16TYK21.76171068
17BLK1.69697887
18IKBKB1.66931538
19TESK21.66022945
20ZAP701.65098421
21CSK1.62341361
22KDR1.43596595
23JAK11.42623655
24SIK31.41239956
25ICK1.37931594
26MAP3K61.35603726
27FES1.33063013
28EPHB11.31856280
29SIK21.30726888
30BTK1.30698171
31TESK11.25611106
32MAP3K31.25443955
33MAP3K131.18202289
34ITK1.14630171
35KIT1.04746971
36MARK21.03925123
37LCK1.03137709
38MAPK71.02712529
39BMPR21.01697363
40SYK1.00704648
41PKN20.99921051
42CHUK0.98618213
43PTK60.98505437
44TTN0.96447065
45RPS6KC10.95500524
46RPS6KL10.95500524
47PDPK10.94739677
48DYRK1B0.93618458
49MAP3K110.93473024
50HIPK20.91821162
51PRKD20.91156334
52HCK0.90429573
53IRAK30.90058309
54JAK30.89296069
55PDK10.88395646
56RPS6KA20.87919094
57MAP3K50.87774538
58RPS6KA60.86486098
59FGFR40.85691726
60CAMKK10.81330174
61SMG10.80659268
62MAP2K60.78821708
63TAOK10.77162338
64LYN0.75084573
65RIPK10.73179045
66CDC42BPA0.72970171
67MAP3K70.72675919
68NEK60.72552164
69JAK20.68655884
70NME20.67238118
71MARK30.63686310
72RET0.62618360
73MAPK40.61258153
74TAOK20.61207357
75MAPK150.60595269
76RPS6KA40.60502892
77MAPK120.60246415
78PRKCQ0.59496358
79CSF1R0.59475975
80MAPK110.58046275
81IRAK20.57584398
82PIM20.57570248
83CDK60.56347517
84PIM10.54895762
85CDK40.53219132
86TLK10.52673916
87STK380.51920862
88GRK70.51189360
89FYN0.50277178
90RPS6KA10.49968920
91MAP3K10.49026140
92IRAK10.48311071
93LRRK20.47480072
94CDK120.42396296
95FGR0.39217379
96MAPK30.39139169
97MATK0.37762268
98MAP2K10.35915441
99BMX0.34950058
100SGK30.34852077

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.83794726
2Other glycan degradation_Homo sapiens_hsa005112.76263725
3B cell receptor signaling pathway_Homo sapiens_hsa046622.42070929
4Osteoclast differentiation_Homo sapiens_hsa043802.27039433
5Leishmaniasis_Homo sapiens_hsa051402.13008104
6T cell receptor signaling pathway_Homo sapiens_hsa046602.08350253
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97739787
8Acute myeloid leukemia_Homo sapiens_hsa052211.92922721
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.91411894
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.86372129
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68945280
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.65605583
13TNF signaling pathway_Homo sapiens_hsa046681.62803880
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62102412
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61419056
16Malaria_Homo sapiens_hsa051441.51718399
17Tuberculosis_Homo sapiens_hsa051521.48624852
18Staphylococcus aureus infection_Homo sapiens_hsa051501.46054827
19Notch signaling pathway_Homo sapiens_hsa043301.44891535
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44790432
21Measles_Homo sapiens_hsa051621.42849874
22Non-small cell lung cancer_Homo sapiens_hsa052231.41319123
23Toxoplasmosis_Homo sapiens_hsa051451.40857372
24Chronic myeloid leukemia_Homo sapiens_hsa052201.34395652
25VEGF signaling pathway_Homo sapiens_hsa043701.32652836
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32209535
27Chemokine signaling pathway_Homo sapiens_hsa040621.30687013
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28682253
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.26395547
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26065914
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20451280
32Shigellosis_Homo sapiens_hsa051311.19839766
33Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.18818604
34Hematopoietic cell lineage_Homo sapiens_hsa046401.18772888
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.18346407
36Platelet activation_Homo sapiens_hsa046111.18152565
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.17676417
38Graft-versus-host disease_Homo sapiens_hsa053321.14106917
39Herpes simplex infection_Homo sapiens_hsa051681.13308306
40Hepatitis B_Homo sapiens_hsa051611.12569019
41Hepatitis C_Homo sapiens_hsa051601.12057762
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.11997998
43Pertussis_Homo sapiens_hsa051331.11302584
44Influenza A_Homo sapiens_hsa051641.09138297
45Allograft rejection_Homo sapiens_hsa053301.07963272
46Legionellosis_Homo sapiens_hsa051341.04406098
47Lysosome_Homo sapiens_hsa041421.03339223
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03072238
49Autoimmune thyroid disease_Homo sapiens_hsa053201.02291911
50Apoptosis_Homo sapiens_hsa042100.97930346
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95757487
52Endocytosis_Homo sapiens_hsa041440.92843840
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92781184
54Viral myocarditis_Homo sapiens_hsa054160.92125482
55Pancreatic cancer_Homo sapiens_hsa052120.91633347
56Antigen processing and presentation_Homo sapiens_hsa046120.88341553
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82684394
58GnRH signaling pathway_Homo sapiens_hsa049120.82644842
59Insulin resistance_Homo sapiens_hsa049310.82567937
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82147683
61Prolactin signaling pathway_Homo sapiens_hsa049170.81275355
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78915749
63Choline metabolism in cancer_Homo sapiens_hsa052310.78064403
64Endometrial cancer_Homo sapiens_hsa052130.76918352
65MAPK signaling pathway_Homo sapiens_hsa040100.75813016
66Salmonella infection_Homo sapiens_hsa051320.75728931
67HTLV-I infection_Homo sapiens_hsa051660.75581267
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.75280971
69Prion diseases_Homo sapiens_hsa050200.73841260
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.72179188
71Inositol phosphate metabolism_Homo sapiens_hsa005620.71965883
72Viral carcinogenesis_Homo sapiens_hsa052030.71241434
73Rheumatoid arthritis_Homo sapiens_hsa053230.70819847
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69345089
75African trypanosomiasis_Homo sapiens_hsa051430.69063681
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68821034
77Long-term potentiation_Homo sapiens_hsa047200.68737232
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.67694920
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66808947
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.66687614
81Insulin signaling pathway_Homo sapiens_hsa049100.66495517
82Colorectal cancer_Homo sapiens_hsa052100.66131208
83mTOR signaling pathway_Homo sapiens_hsa041500.60943903
84ErbB signaling pathway_Homo sapiens_hsa040120.60883945
85Prostate cancer_Homo sapiens_hsa052150.55892649
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54756869
87Small cell lung cancer_Homo sapiens_hsa052220.54433998
88FoxO signaling pathway_Homo sapiens_hsa040680.54398187
89Renal cell carcinoma_Homo sapiens_hsa052110.53500748
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53359088
91Estrogen signaling pathway_Homo sapiens_hsa049150.53294250
92ABC transporters_Homo sapiens_hsa020100.52362507
93Epstein-Barr virus infection_Homo sapiens_hsa051690.52343819
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50248765
95Type I diabetes mellitus_Homo sapiens_hsa049400.48652757
96Bladder cancer_Homo sapiens_hsa052190.47966772
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44485775
98Phagosome_Homo sapiens_hsa041450.43749807
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.41664089
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40924688

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