

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle exocytosis (GO:0016079) | 5.90426310 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.86312124 |
| 3 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.46742491 |
| 4 | vocalization behavior (GO:0071625) | 5.28969921 |
| 5 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.27811482 |
| 6 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.16890247 |
| 7 | glutamate secretion (GO:0014047) | 5.14892291 |
| 8 | synaptic vesicle maturation (GO:0016188) | 5.12613114 |
| 9 | protein localization to synapse (GO:0035418) | 5.09888616 |
| 10 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.09436862 |
| 11 | locomotory exploration behavior (GO:0035641) | 4.86451086 |
| 12 | glutamate receptor signaling pathway (GO:0007215) | 4.78363574 |
| 13 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.75834863 |
| 14 | neuronal action potential propagation (GO:0019227) | 4.72951009 |
| 15 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.71533267 |
| 16 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 4.69710299 |
| 17 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.62846701 |
| 18 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.57732170 |
| 19 | neuron cell-cell adhesion (GO:0007158) | 4.57668087 |
| 20 | L-amino acid import (GO:0043092) | 4.54713882 |
| 21 | cellular potassium ion homeostasis (GO:0030007) | 4.54441772 |
| 22 | regulation of synaptic vesicle transport (GO:1902803) | 4.46977125 |
| 23 | neuron-neuron synaptic transmission (GO:0007270) | 4.40355247 |
| 24 | synaptic transmission, glutamatergic (GO:0035249) | 4.39043543 |
| 25 | positive regulation of synapse maturation (GO:0090129) | 4.36015994 |
| 26 | neurotransmitter secretion (GO:0007269) | 4.30148271 |
| 27 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.30056505 |
| 28 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 4.18615986 |
| 29 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.05739224 |
| 30 | exploration behavior (GO:0035640) | 4.00496284 |
| 31 | amino acid import (GO:0043090) | 3.98417335 |
| 32 | potassium ion import (GO:0010107) | 3.95288621 |
| 33 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.94524266 |
| 34 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.91950341 |
| 35 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.89549443 |
| 36 | long-term memory (GO:0007616) | 3.87927071 |
| 37 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.86057204 |
| 38 | neuronal ion channel clustering (GO:0045161) | 3.83122907 |
| 39 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.82955928 |
| 40 | regulation of postsynaptic membrane potential (GO:0060078) | 3.79955112 |
| 41 | long-term synaptic potentiation (GO:0060291) | 3.78024757 |
| 42 | layer formation in cerebral cortex (GO:0021819) | 3.77284602 |
| 43 | positive regulation of membrane potential (GO:0045838) | 3.75515358 |
| 44 | cerebellar granule cell differentiation (GO:0021707) | 3.73142916 |
| 45 | neurotransmitter transport (GO:0006836) | 3.72645140 |
| 46 | cellular sodium ion homeostasis (GO:0006883) | 3.72192246 |
| 47 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.71911738 |
| 48 | sodium ion export (GO:0071436) | 3.71179364 |
| 49 | response to pheromone (GO:0019236) | 3.70976897 |
| 50 | axon ensheathment in central nervous system (GO:0032291) | 3.69774046 |
| 51 | central nervous system myelination (GO:0022010) | 3.69774046 |
| 52 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.69543581 |
| 53 | * synaptic vesicle endocytosis (GO:0048488) | 3.67030000 |
| 54 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.66271006 |
| 55 | regulation of neurotransmitter secretion (GO:0046928) | 3.63789537 |
| 56 | response to histamine (GO:0034776) | 3.58769633 |
| 57 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.57316111 |
| 58 | transmission of nerve impulse (GO:0019226) | 3.54912574 |
| 59 | neuron recognition (GO:0008038) | 3.51831756 |
| 60 | regulation of synapse maturation (GO:0090128) | 3.51338828 |
| 61 | gamma-aminobutyric acid transport (GO:0015812) | 3.48412405 |
| 62 | regulation of synapse structural plasticity (GO:0051823) | 3.47633542 |
| 63 | regulation of vesicle fusion (GO:0031338) | 3.46973388 |
| 64 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.46858683 |
| 65 | presynaptic membrane assembly (GO:0097105) | 3.46448959 |
| 66 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.44634228 |
| 67 | innervation (GO:0060384) | 3.44621396 |
| 68 | regulation of synaptic plasticity (GO:0048167) | 3.42372179 |
| 69 | behavioral response to cocaine (GO:0048148) | 3.40861336 |
| 70 | long term synaptic depression (GO:0060292) | 3.40104611 |
| 71 | neuromuscular process controlling balance (GO:0050885) | 3.40000559 |
| 72 | neurotransmitter uptake (GO:0001504) | 3.38002837 |
| 73 | membrane hyperpolarization (GO:0060081) | 3.37431670 |
| 74 | dendritic spine morphogenesis (GO:0060997) | 3.35960053 |
| 75 | auditory behavior (GO:0031223) | 3.35791506 |
| 76 | regulation of neurotransmitter transport (GO:0051588) | 3.35278725 |
| 77 | presynaptic membrane organization (GO:0097090) | 3.34805841 |
| 78 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.34385971 |
| 79 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.32900691 |
| 80 | regulation of ARF protein signal transduction (GO:0032012) | 3.32211265 |
| 81 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.30756523 |
| 82 | regulation of neurotransmitter levels (GO:0001505) | 3.28710935 |
| 83 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.28242343 |
| 84 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.27884737 |
| 85 | membrane depolarization (GO:0051899) | 3.27483372 |
| 86 | behavioral fear response (GO:0001662) | 3.24992902 |
| 87 | behavioral defense response (GO:0002209) | 3.24992902 |
| 88 | postsynaptic membrane organization (GO:0001941) | 3.24524562 |
| 89 | mating behavior (GO:0007617) | 3.23984782 |
| 90 | acidic amino acid transport (GO:0015800) | 3.22465583 |
| 91 | membrane depolarization during action potential (GO:0086010) | 3.21935007 |
| 92 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.17971802 |
| 93 | proline transport (GO:0015824) | 3.17392538 |
| 94 | potassium ion homeostasis (GO:0055075) | 3.16828157 |
| 95 | neuromuscular process controlling posture (GO:0050884) | 3.13740400 |
| 96 | chemosensory behavior (GO:0007635) | 3.13729546 |
| 97 | fear response (GO:0042596) | 3.13646805 |
| 98 | synapse assembly (GO:0007416) | 3.13509328 |
| 99 | synaptic transmission (GO:0007268) | 3.12915664 |
| 100 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.11676365 |
| 101 | righting reflex (GO:0060013) | 3.10895581 |
| 102 | positive regulation of neurotransmitter transport (GO:0051590) | 3.10664580 |
| 103 | dendritic spine organization (GO:0097061) | 3.08736323 |
| 104 | axonal fasciculation (GO:0007413) | 3.08389790 |
| 105 | regulation of exocytosis (GO:0017157) | 3.08224497 |
| 106 | learning (GO:0007612) | 3.07020920 |
| 107 | positive regulation of dendritic spine development (GO:0060999) | 3.06110389 |
| 108 | vesicle docking involved in exocytosis (GO:0006904) | 3.04060098 |
| 109 | C4-dicarboxylate transport (GO:0015740) | 3.03898864 |
| 110 | cerebellar Purkinje cell layer development (GO:0021680) | 3.01834323 |
| 111 | cell communication involved in cardiac conduction (GO:0086065) | 3.00986683 |
| 112 | * establishment of synaptic vesicle localization (GO:0097480) | 3.00728460 |
| 113 | * synaptic vesicle transport (GO:0048489) | 3.00728460 |
| 114 | cell communication by electrical coupling (GO:0010644) | 3.00568775 |
| 115 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 3.00028172 |
| 116 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.98831360 |
| 117 | adult walking behavior (GO:0007628) | 2.98499858 |
| 118 | regulation of synaptic transmission (GO:0050804) | 2.98462710 |
| 119 | positive regulation of synaptic transmission (GO:0050806) | 2.98191762 |
| 120 | detection of calcium ion (GO:0005513) | 2.92839905 |
| 121 | regulation of dendritic spine development (GO:0060998) | 2.90339164 |
| 122 | cell differentiation in hindbrain (GO:0021533) | 2.89477684 |
| 123 | activation of protein kinase A activity (GO:0034199) | 2.88720956 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.67232098 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.05773802 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.13048206 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.08509213 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.05496113 |
| 6 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.76051189 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.65115583 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.65115583 |
| 9 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.62657473 |
| 10 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.58726801 |
| 11 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.54309277 |
| 12 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.47657136 |
| 13 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.43430632 |
| 14 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.43421544 |
| 15 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.36759684 |
| 16 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.35362427 |
| 17 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.33771212 |
| 18 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.24205177 |
| 19 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.22657958 |
| 20 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.20175237 |
| 21 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.18311240 |
| 22 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.17700843 |
| 23 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.15484468 |
| 24 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.14923558 |
| 25 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.12034175 |
| 26 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.00899757 |
| 27 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.99133730 |
| 28 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.93129204 |
| 29 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.88533219 |
| 30 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.86401584 |
| 31 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.83895295 |
| 32 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.81900267 |
| 33 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.78807850 |
| 34 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.77591695 |
| 35 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.71639078 |
| 36 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.61163716 |
| 37 | P300_19829295_ChIP-Seq_ESCs_Human | 1.60686295 |
| 38 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.57846255 |
| 39 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.57418474 |
| 40 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.55110483 |
| 41 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.47703430 |
| 42 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.43114254 |
| 43 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.41717336 |
| 44 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.40051379 |
| 45 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.39579161 |
| 46 | * POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.38261531 |
| 47 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.36691419 |
| 48 | VDR_22108803_ChIP-Seq_LS180_Human | 1.36633399 |
| 49 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.35664898 |
| 50 | AR_25329375_ChIP-Seq_VCAP_Human | 1.34295345 |
| 51 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.33340946 |
| 52 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.33328585 |
| 53 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.32661352 |
| 54 | STAT3_23295773_ChIP-Seq_U87_Human | 1.28779396 |
| 55 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.27872936 |
| 56 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.27533428 |
| 57 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.26853831 |
| 58 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.26833179 |
| 59 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.26771985 |
| 60 | * FUS_26573619_Chip-Seq_HEK293_Human | 1.26457574 |
| 61 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.25495875 |
| 62 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.25121067 |
| 63 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.24386379 |
| 64 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.23889065 |
| 65 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.22596972 |
| 66 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.20949112 |
| 67 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.20404844 |
| 68 | TCF4_23295773_ChIP-Seq_U87_Human | 1.18801504 |
| 69 | AR_19668381_ChIP-Seq_PC3_Human | 1.17995778 |
| 70 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.17588388 |
| 71 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.16759690 |
| 72 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.12093368 |
| 73 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.11153385 |
| 74 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.07510635 |
| 75 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.07136513 |
| 76 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.05394948 |
| 77 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.05014402 |
| 78 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.04852952 |
| 79 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.04783500 |
| 80 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.03932286 |
| 81 | * TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.03730315 |
| 82 | * NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.03591786 |
| 83 | KDM2B_26808549_Chip-Seq_K562_Human | 1.03550140 |
| 84 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.03284288 |
| 85 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.01280001 |
| 86 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.00806760 |
| 87 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.00486115 |
| 88 | TP53_16413492_ChIP-PET_HCT116_Human | 0.98872184 |
| 89 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.98295011 |
| 90 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.97674135 |
| 91 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97674135 |
| 92 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.95162090 |
| 93 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.95011014 |
| 94 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94747842 |
| 95 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.93849279 |
| 96 | JUN_21703547_ChIP-Seq_K562_Human | 0.93006799 |
| 97 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.92884051 |
| 98 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.92531286 |
| 99 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.91780861 |
| 100 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.91666152 |
| 101 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.91446271 |
| 102 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.91177932 |
| 103 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.90811245 |
| 104 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.90322451 |
| 105 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.90221591 |
| 106 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.90162638 |
| 107 | * SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.90023124 |
| 108 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.89894200 |
| 109 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.89884088 |
| 110 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.88796323 |
| 111 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.88652677 |
| 112 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.86176809 |
| 113 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.83994755 |
| 114 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.83598827 |
| 115 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.82281482 |
| 116 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.81737609 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.78602256 |
| 2 | MP0003880_abnormal_central_pattern | 5.36377802 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.06638245 |
| 4 | MP0009046_muscle_twitch | 3.46325559 |
| 5 | MP0009745_abnormal_behavioral_response | 3.40590566 |
| 6 | MP0004270_analgesia | 3.37294760 |
| 7 | MP0002064_seizures | 3.24495667 |
| 8 | MP0002063_abnormal_learning/memory/cond | 3.21617264 |
| 9 | MP0001968_abnormal_touch/_nociception | 3.11087307 |
| 10 | MP0002272_abnormal_nervous_system | 2.82725950 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 2.81063996 |
| 12 | MP0001486_abnormal_startle_reflex | 2.65742804 |
| 13 | MP0005423_abnormal_somatic_nervous | 2.64976874 |
| 14 | MP0002734_abnormal_mechanical_nocicepti | 2.61515108 |
| 15 | MP0002736_abnormal_nociception_after | 2.55822480 |
| 16 | MP0001501_abnormal_sleep_pattern | 2.36935156 |
| 17 | MP0001440_abnormal_grooming_behavior | 2.31136472 |
| 18 | MP0002067_abnormal_sensory_capabilities | 2.25469250 |
| 19 | MP0002735_abnormal_chemical_nociception | 2.21634710 |
| 20 | MP0001984_abnormal_olfaction | 2.10155202 |
| 21 | MP0005551_abnormal_eye_electrophysiolog | 2.07703544 |
| 22 | MP0008569_lethality_at_weaning | 2.00410938 |
| 23 | MP0002184_abnormal_innervation | 1.97998737 |
| 24 | MP0001970_abnormal_pain_threshold | 1.88308881 |
| 25 | MP0002822_catalepsy | 1.85479843 |
| 26 | MP0002733_abnormal_thermal_nociception | 1.84469088 |
| 27 | MP0004924_abnormal_behavior | 1.72439962 |
| 28 | MP0005386_behavior/neurological_phenoty | 1.72439962 |
| 29 | MP0002557_abnormal_social/conspecific_i | 1.71462110 |
| 30 | MP0003879_abnormal_hair_cell | 1.71133990 |
| 31 | MP0000778_abnormal_nervous_system | 1.70841449 |
| 32 | MP0006276_abnormal_autonomic_nervous | 1.68469655 |
| 33 | MP0003329_amyloid_beta_deposits | 1.68437043 |
| 34 | MP0001502_abnormal_circadian_rhythm | 1.63244221 |
| 35 | MP0001188_hyperpigmentation | 1.54619896 |
| 36 | MP0004811_abnormal_neuron_physiology | 1.53850855 |
| 37 | MP0003123_paternal_imprinting | 1.51325814 |
| 38 | MP0000955_abnormal_spinal_cord | 1.49906135 |
| 39 | MP0004142_abnormal_muscle_tone | 1.48411273 |
| 40 | MP0002882_abnormal_neuron_morphology | 1.47511921 |
| 41 | MP0008877_abnormal_DNA_methylation | 1.46944178 |
| 42 | MP0001529_abnormal_vocalization | 1.45420501 |
| 43 | MP0005646_abnormal_pituitary_gland | 1.45193121 |
| 44 | MP0004145_abnormal_muscle_electrophysio | 1.44818736 |
| 45 | MP0002066_abnormal_motor_capabilities/c | 1.42285095 |
| 46 | MP0002909_abnormal_adrenal_gland | 1.41359189 |
| 47 | MP0009780_abnormal_chondrocyte_physiolo | 1.41339068 |
| 48 | MP0003787_abnormal_imprinting | 1.40120816 |
| 49 | MP0010386_abnormal_urinary_bladder | 1.35512752 |
| 50 | MP0006072_abnormal_retinal_apoptosis | 1.33792509 |
| 51 | MP0001905_abnormal_dopamine_level | 1.32875480 |
| 52 | MP0004742_abnormal_vestibular_system | 1.29173397 |
| 53 | MP0004885_abnormal_endolymph | 1.28115293 |
| 54 | MP0002229_neurodegeneration | 1.24503367 |
| 55 | MP0003633_abnormal_nervous_system | 1.24348435 |
| 56 | MP0004147_increased_porphyrin_level | 1.24179536 |
| 57 | MP0002090_abnormal_vision | 1.22554740 |
| 58 | MP0004858_abnormal_nervous_system | 1.20700561 |
| 59 | MP0005645_abnormal_hypothalamus_physiol | 1.11218919 |
| 60 | MP0003631_nervous_system_phenotype | 1.09158946 |
| 61 | MP0002152_abnormal_brain_morphology | 1.06816244 |
| 62 | MP0005394_taste/olfaction_phenotype | 1.03304375 |
| 63 | MP0005499_abnormal_olfactory_system | 1.03304375 |
| 64 | MP0008872_abnormal_physiological_respon | 1.03159554 |
| 65 | MP0001963_abnormal_hearing_physiology | 1.00832322 |
| 66 | MP0003122_maternal_imprinting | 1.00156412 |
| 67 | MP0002837_dystrophic_cardiac_calcinosis | 0.99571988 |
| 68 | MP0005253_abnormal_eye_physiology | 0.99510083 |
| 69 | MP0002752_abnormal_somatic_nervous | 0.99462092 |
| 70 | MP0004215_abnormal_myocardial_fiber | 0.91352500 |
| 71 | MP0002069_abnormal_eating/drinking_beha | 0.89636489 |
| 72 | MP0006292_abnormal_olfactory_placode | 0.89604722 |
| 73 | MP0001986_abnormal_taste_sensitivity | 0.87690508 |
| 74 | MP0000631_abnormal_neuroendocrine_gland | 0.87156342 |
| 75 | MP0000751_myopathy | 0.86309512 |
| 76 | MP0003632_abnormal_nervous_system | 0.82271258 |
| 77 | MP0002638_abnormal_pupillary_reflex | 0.81761103 |
| 78 | MP0008874_decreased_physiological_sensi | 0.81572840 |
| 79 | MP0003121_genomic_imprinting | 0.80873535 |
| 80 | MP0003634_abnormal_glial_cell | 0.80822084 |
| 81 | MP0004085_abnormal_heartbeat | 0.79890484 |
| 82 | MP0004233_abnormal_muscle_weight | 0.78959255 |
| 83 | MP0000920_abnormal_myelination | 0.78363087 |
| 84 | MP0005535_abnormal_body_temperature | 0.77511669 |
| 85 | MP0004043_abnormal_pH_regulation | 0.77194870 |
| 86 | MP0001485_abnormal_pinna_reflex | 0.76306249 |
| 87 | MP0004484_altered_response_of | 0.73918733 |
| 88 | MP0000013_abnormal_adipose_tissue | 0.73633928 |
| 89 | MP0001348_abnormal_lacrimal_gland | 0.73208065 |
| 90 | MP0003172_abnormal_lysosome_physiology | 0.72308971 |
| 91 | MP0001664_abnormal_digestion | 0.72265714 |
| 92 | MP0005409_darkened_coat_color | 0.71922997 |
| 93 | MP0002876_abnormal_thyroid_physiology | 0.71108034 |
| 94 | MP0005167_abnormal_blood-brain_barrier | 0.67843991 |
| 95 | MP0001177_atelectasis | 0.67787612 |
| 96 | MP0003075_altered_response_to | 0.66862897 |
| 97 | MP0005195_abnormal_posterior_eye | 0.66593609 |
| 98 | MP0000026_abnormal_inner_ear | 0.64552212 |
| 99 | MP0000604_amyloidosis | 0.63989611 |
| 100 | MP0003137_abnormal_impulse_conducting | 0.61806667 |
| 101 | MP0005171_absent_coat_pigmentation | 0.61004007 |
| 102 | MP0003283_abnormal_digestive_organ | 0.57484335 |
| 103 | MP0003690_abnormal_glial_cell | 0.56442147 |
| 104 | MP0010768_mortality/aging | 0.54735825 |
| 105 | MP0010234_abnormal_vibrissa_follicle | 0.54311799 |
| 106 | MP0001346_abnormal_lacrimal_gland | 0.53912712 |
| 107 | MP0001943_abnormal_respiration | 0.52924748 |
| 108 | MP0003956_abnormal_body_size | 0.52882428 |
| 109 | MP0010769_abnormal_survival | 0.51665785 |
| 110 | MP0005623_abnormal_meninges_morphology | 0.50905664 |
| 111 | MP0010770_preweaning_lethality | 0.50710390 |
| 112 | MP0002082_postnatal_lethality | 0.50710390 |
| 113 | MP0003861_abnormal_nervous_system | 0.49927641 |
| 114 | MP0002653_abnormal_ependyma_morphology | 0.48124935 |
| 115 | MP0001944_abnormal_pancreas_morphology | 0.48054222 |
| 116 | MP0000639_abnormal_adrenal_gland | 0.47541415 |
| 117 | MP0001765_abnormal_ion_homeostasis | 0.44766509 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.89953819 |
| 2 | Myokymia (HP:0002411) | 5.86814362 |
| 3 | Focal seizures (HP:0007359) | 5.71823493 |
| 4 | Epileptic encephalopathy (HP:0200134) | 5.59799753 |
| 5 | Visual hallucinations (HP:0002367) | 5.43294638 |
| 6 | Febrile seizures (HP:0002373) | 5.34611670 |
| 7 | Atonic seizures (HP:0010819) | 5.29019079 |
| 8 | Absence seizures (HP:0002121) | 4.94115170 |
| 9 | Progressive cerebellar ataxia (HP:0002073) | 4.91999590 |
| 10 | Dialeptic seizures (HP:0011146) | 4.49431964 |
| 11 | Generalized tonic-clonic seizures (HP:0002069) | 4.13317042 |
| 12 | Congenital stationary night blindness (HP:0007642) | 3.88314965 |
| 13 | Gaze-evoked nystagmus (HP:0000640) | 3.83881446 |
| 14 | Action tremor (HP:0002345) | 3.81876597 |
| 15 | Broad-based gait (HP:0002136) | 3.63032021 |
| 16 | Hyperventilation (HP:0002883) | 3.62333394 |
| 17 | Dysdiadochokinesis (HP:0002075) | 3.48072535 |
| 18 | Cerebral hypomyelination (HP:0006808) | 3.46943276 |
| 19 | Papilledema (HP:0001085) | 3.35399746 |
| 20 | Supranuclear gaze palsy (HP:0000605) | 3.29253430 |
| 21 | Dysmetria (HP:0001310) | 3.21102212 |
| 22 | Truncal ataxia (HP:0002078) | 3.20513561 |
| 23 | Tetraplegia (HP:0002445) | 3.13730472 |
| 24 | Hemiparesis (HP:0001269) | 3.11532816 |
| 25 | Poor eye contact (HP:0000817) | 2.98662468 |
| 26 | Depression (HP:0000716) | 2.92396269 |
| 27 | Amblyopia (HP:0000646) | 2.90311245 |
| 28 | Scanning speech (HP:0002168) | 2.86875325 |
| 29 | Annular pancreas (HP:0001734) | 2.86740674 |
| 30 | Akinesia (HP:0002304) | 2.85693161 |
| 31 | Impaired smooth pursuit (HP:0007772) | 2.83393065 |
| 32 | Anxiety (HP:0000739) | 2.83223300 |
| 33 | Drooling (HP:0002307) | 2.77562323 |
| 34 | Excessive salivation (HP:0003781) | 2.77562323 |
| 35 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.76429339 |
| 36 | Central scotoma (HP:0000603) | 2.74599583 |
| 37 | Genetic anticipation (HP:0003743) | 2.71742693 |
| 38 | Epileptiform EEG discharges (HP:0011182) | 2.71655396 |
| 39 | Abnormality of macular pigmentation (HP:0008002) | 2.69277852 |
| 40 | Obstructive sleep apnea (HP:0002870) | 2.68168986 |
| 41 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.67921718 |
| 42 | Abnormal eating behavior (HP:0100738) | 2.67817209 |
| 43 | Ankle clonus (HP:0011448) | 2.67442310 |
| 44 | Abnormality of binocular vision (HP:0011514) | 2.67280887 |
| 45 | Diplopia (HP:0000651) | 2.67280887 |
| 46 | Impaired social interactions (HP:0000735) | 2.62847068 |
| 47 | Abnormal social behavior (HP:0012433) | 2.62847068 |
| 48 | Absent speech (HP:0001344) | 2.62009865 |
| 49 | Craniofacial dystonia (HP:0012179) | 2.61799533 |
| 50 | Mutism (HP:0002300) | 2.61440857 |
| 51 | Dysmetric saccades (HP:0000641) | 2.58771015 |
| 52 | Postural instability (HP:0002172) | 2.58613296 |
| 53 | EEG with generalized epileptiform discharges (HP:0011198) | 2.57283889 |
| 54 | Cerebral inclusion bodies (HP:0100314) | 2.56269215 |
| 55 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.55104380 |
| 56 | Sleep apnea (HP:0010535) | 2.52637325 |
| 57 | Status epilepticus (HP:0002133) | 2.41113206 |
| 58 | Clonus (HP:0002169) | 2.40635558 |
| 59 | Neurofibrillary tangles (HP:0002185) | 2.40441087 |
| 60 | Gait imbalance (HP:0002141) | 2.38929222 |
| 61 | Spastic gait (HP:0002064) | 2.35819764 |
| 62 | Abnormality of the lower motor neuron (HP:0002366) | 2.34036393 |
| 63 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.32833693 |
| 64 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.32833693 |
| 65 | Progressive inability to walk (HP:0002505) | 2.30122780 |
| 66 | Apathy (HP:0000741) | 2.29988461 |
| 67 | Intention tremor (HP:0002080) | 2.27666458 |
| 68 | Inability to walk (HP:0002540) | 2.27427812 |
| 69 | Fetal akinesia sequence (HP:0001989) | 2.27175110 |
| 70 | Increased circulating renin level (HP:0000848) | 2.26223999 |
| 71 | Bradykinesia (HP:0002067) | 2.24586837 |
| 72 | Choreoathetosis (HP:0001266) | 2.23411123 |
| 73 | Generalized myoclonic seizures (HP:0002123) | 2.21619600 |
| 74 | Hypsarrhythmia (HP:0002521) | 2.20144377 |
| 75 | Postural tremor (HP:0002174) | 2.18362029 |
| 76 | Rigidity (HP:0002063) | 2.17771863 |
| 77 | Abnormality of the corticospinal tract (HP:0002492) | 2.16409778 |
| 78 | Hemiplegia (HP:0002301) | 2.16208439 |
| 79 | CNS hypomyelination (HP:0003429) | 2.14771150 |
| 80 | Stereotypic behavior (HP:0000733) | 2.14288622 |
| 81 | Delusions (HP:0000746) | 2.13382932 |
| 82 | Congenital primary aphakia (HP:0007707) | 2.11080622 |
| 83 | Ventricular fibrillation (HP:0001663) | 2.08761892 |
| 84 | Diminished motivation (HP:0000745) | 2.08165094 |
| 85 | Hypoglycemic seizures (HP:0002173) | 2.06968544 |
| 86 | Spastic tetraparesis (HP:0001285) | 2.05176656 |
| 87 | Medial flaring of the eyebrow (HP:0010747) | 2.05153578 |
| 88 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.02142391 |
| 89 | Termporal pattern (HP:0011008) | 2.00982728 |
| 90 | Insidious onset (HP:0003587) | 2.00982728 |
| 91 | Urinary urgency (HP:0000012) | 2.00742272 |
| 92 | Impaired vibratory sensation (HP:0002495) | 2.00663955 |
| 93 | Decreased central vision (HP:0007663) | 2.00502960 |
| 94 | Peripheral hypomyelination (HP:0007182) | 2.00260563 |
| 95 | Pheochromocytoma (HP:0002666) | 1.99730707 |
| 96 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.99031740 |
| 97 | Gait ataxia (HP:0002066) | 1.98390490 |
| 98 | Incomplete penetrance (HP:0003829) | 1.97599984 |
| 99 | Polyphagia (HP:0002591) | 1.97251012 |
| 100 | Protruding tongue (HP:0010808) | 1.96718517 |
| 101 | Nephrogenic diabetes insipidus (HP:0009806) | 1.95131348 |
| 102 | Lower limb asymmetry (HP:0100559) | 1.94429604 |
| 103 | Rapidly progressive (HP:0003678) | 1.90899040 |
| 104 | Blue irides (HP:0000635) | 1.88791596 |
| 105 | Specific learning disability (HP:0001328) | 1.88358283 |
| 106 | Retinal dysplasia (HP:0007973) | 1.88240710 |
| 107 | Abnormality of salivation (HP:0100755) | 1.88222663 |
| 108 | Lower limb muscle weakness (HP:0007340) | 1.86212368 |
| 109 | Bundle branch block (HP:0011710) | 1.84214366 |
| 110 | Torticollis (HP:0000473) | 1.83553203 |
| 111 | Abnormality of saccadic eye movements (HP:0000570) | 1.81260253 |
| 112 | Spastic tetraplegia (HP:0002510) | 1.80928734 |
| 113 | Psychosis (HP:0000709) | 1.79101228 |
| 114 | Limb ataxia (HP:0002070) | 1.78849563 |
| 115 | Focal dystonia (HP:0004373) | 1.78177037 |
| 116 | Neuroendocrine neoplasm (HP:0100634) | 1.75616438 |
| 117 | Diminished movement (HP:0002374) | 1.74400927 |
| 118 | Muscular hypotonia of the trunk (HP:0008936) | 1.74106733 |
| 119 | Paraplegia (HP:0010550) | 1.74069949 |
| 120 | Absent/shortened dynein arms (HP:0200106) | 1.73331182 |
| 121 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.73331182 |
| 122 | Prolonged QT interval (HP:0001657) | 1.72142034 |
| 123 | Scotoma (HP:0000575) | 1.72064431 |
| 124 | Esotropia (HP:0000565) | 1.70922432 |
| 125 | Neuronal loss in central nervous system (HP:0002529) | 1.70617271 |
| 126 | Horizontal nystagmus (HP:0000666) | 1.70528369 |
| 127 | Genital tract atresia (HP:0001827) | 1.69733223 |
| 128 | Agitation (HP:0000713) | 1.68760248 |
| 129 | Widely spaced teeth (HP:0000687) | 1.68036054 |
| 130 | Limb dystonia (HP:0002451) | 1.67939556 |
| 131 | Choroideremia (HP:0001139) | 1.67662287 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.13558344 |
| 2 | EPHA4 | 4.03184011 |
| 3 | MAP3K4 | 3.47653798 |
| 4 | MAP3K9 | 3.41811588 |
| 5 | MAP2K7 | 2.92764765 |
| 6 | CASK | 2.84216438 |
| 7 | NEK1 | 2.68225803 |
| 8 | MINK1 | 2.57711367 |
| 9 | MAP3K12 | 2.52781627 |
| 10 | RIPK4 | 2.52566217 |
| 11 | MARK1 | 2.36076613 |
| 12 | DAPK2 | 2.32486837 |
| 13 | PAK6 | 2.29697450 |
| 14 | MAP2K4 | 2.08089085 |
| 15 | CDK19 | 1.93507620 |
| 16 | PLK2 | 1.93042463 |
| 17 | PNCK | 1.91886017 |
| 18 | TNIK | 1.75953587 |
| 19 | GRK5 | 1.74389461 |
| 20 | PRPF4B | 1.74012498 |
| 21 | NTRK2 | 1.64644369 |
| 22 | KSR2 | 1.59091157 |
| 23 | DAPK1 | 1.56623440 |
| 24 | ARAF | 1.47198434 |
| 25 | CAMKK1 | 1.46221942 |
| 26 | CAMKK2 | 1.42235248 |
| 27 | CDK5 | 1.41404244 |
| 28 | KSR1 | 1.38790681 |
| 29 | OXSR1 | 1.37677229 |
| 30 | MAP3K13 | 1.33929167 |
| 31 | STK38 | 1.31341105 |
| 32 | SIK2 | 1.31101176 |
| 33 | MAPK13 | 1.31018305 |
| 34 | FGFR2 | 1.28547901 |
| 35 | NTRK1 | 1.27870346 |
| 36 | PRKCG | 1.26473053 |
| 37 | FES | 1.25318604 |
| 38 | FRK | 1.23082346 |
| 39 | BMPR2 | 1.23003304 |
| 40 | PRKD3 | 1.17532069 |
| 41 | NME1 | 1.15148928 |
| 42 | CAMK2A | 1.13174486 |
| 43 | RIPK1 | 1.09352988 |
| 44 | DYRK1A | 1.01121314 |
| 45 | UHMK1 | 1.00562869 |
| 46 | PTK2B | 0.98541183 |
| 47 | CAMK1 | 0.96335963 |
| 48 | CAMK2B | 0.96043785 |
| 49 | SGK223 | 0.94327796 |
| 50 | SGK494 | 0.94327796 |
| 51 | CDK18 | 0.91106794 |
| 52 | CDK14 | 0.89227482 |
| 53 | CDK15 | 0.88998921 |
| 54 | FGR | 0.86248667 |
| 55 | ALK | 0.78312825 |
| 56 | CDK11A | 0.78246821 |
| 57 | CAMK2D | 0.77765717 |
| 58 | PINK1 | 0.77341882 |
| 59 | TNK2 | 0.77059478 |
| 60 | PHKG1 | 0.76245354 |
| 61 | PHKG2 | 0.76245354 |
| 62 | AKT3 | 0.75114677 |
| 63 | STK11 | 0.73762608 |
| 64 | LIMK1 | 0.73721222 |
| 65 | WNK1 | 0.72923592 |
| 66 | CCNB1 | 0.69791871 |
| 67 | SGK2 | 0.69575120 |
| 68 | TYRO3 | 0.69477071 |
| 69 | RAF1 | 0.69207139 |
| 70 | SGK1 | 0.65498193 |
| 71 | PRKCE | 0.63698204 |
| 72 | FER | 0.63658880 |
| 73 | MAPK12 | 0.62709778 |
| 74 | PAK3 | 0.62383294 |
| 75 | TESK1 | 0.61983201 |
| 76 | SIK3 | 0.60785983 |
| 77 | MAP3K2 | 0.59655433 |
| 78 | CAMK1G | 0.59645456 |
| 79 | CAMK2G | 0.57363769 |
| 80 | MAP3K6 | 0.57300029 |
| 81 | MAP4K2 | 0.55215184 |
| 82 | NEK6 | 0.54237573 |
| 83 | BRSK1 | 0.53679793 |
| 84 | PRKCH | 0.53571611 |
| 85 | GRK7 | 0.50858724 |
| 86 | STK39 | 0.50801113 |
| 87 | CDK3 | 0.49323536 |
| 88 | MARK2 | 0.49093550 |
| 89 | LATS2 | 0.49007972 |
| 90 | RET | 0.47532832 |
| 91 | BCR | 0.47468124 |
| 92 | DAPK3 | 0.46754111 |
| 93 | WNK3 | 0.46394656 |
| 94 | PDK1 | 0.45872248 |
| 95 | CSNK1G2 | 0.45099128 |
| 96 | SGK3 | 0.44212976 |
| 97 | RPS6KA3 | 0.44105790 |
| 98 | BRAF | 0.43011743 |
| 99 | MAP3K1 | 0.42147387 |
| 100 | PDPK1 | 0.41863461 |
| 101 | CAMK4 | 0.41485289 |
| 102 | MAPK10 | 0.41418468 |
| 103 | LMTK2 | 0.40310049 |
| 104 | PRKCZ | 0.39968760 |
| 105 | ADRBK2 | 0.39769419 |
| 106 | FYN | 0.39045938 |
| 107 | MAP3K7 | 0.38529925 |
| 108 | IRAK2 | 0.38121228 |
| 109 | PRKG1 | 0.37501464 |
| 110 | PRKCA | 0.37493972 |
| 111 | PRKACA | 0.37452148 |
| 112 | PKN1 | 0.36975668 |
| 113 | CDC42BPA | 0.36140045 |
| 114 | CSNK1G3 | 0.35901647 |
| 115 | MAPKAPK5 | 0.35573553 |
| 116 | CSNK1A1 | 0.35418166 |
| 117 | PRKG2 | 0.33417346 |
| 118 | ROCK1 | 0.30325406 |
| 119 | MAP2K6 | 0.30313641 |
| 120 | CSNK1D | 0.30065091 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.43339634 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.61404761 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 3.08951246 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 2.94569178 |
| 5 | Morphine addiction_Homo sapiens_hsa05032 | 2.77794884 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.76523999 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.69410909 |
| 8 | Long-term potentiation_Homo sapiens_hsa04720 | 2.61329360 |
| 9 | Olfactory transduction_Homo sapiens_hsa04740 | 2.58065074 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.36817976 |
| 11 | Salivary secretion_Homo sapiens_hsa04970 | 2.30135758 |
| 12 | Taste transduction_Homo sapiens_hsa04742 | 2.13987426 |
| 13 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.12527104 |
| 14 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.10147716 |
| 15 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.05161605 |
| 16 | Insulin secretion_Homo sapiens_hsa04911 | 2.05081456 |
| 17 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.95946274 |
| 18 | Renin secretion_Homo sapiens_hsa04924 | 1.87673821 |
| 19 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.86826711 |
| 20 | Long-term depression_Homo sapiens_hsa04730 | 1.81470501 |
| 21 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.80334903 |
| 22 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.80008822 |
| 23 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.75315827 |
| 24 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.69278764 |
| 25 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.65825208 |
| 26 | Phototransduction_Homo sapiens_hsa04744 | 1.59869127 |
| 27 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.53260613 |
| 28 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.41219518 |
| 29 | Cocaine addiction_Homo sapiens_hsa05030 | 1.34750246 |
| 30 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.34164957 |
| 31 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.29427866 |
| 32 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.26533424 |
| 33 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.26365858 |
| 34 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.22657744 |
| 35 | Gap junction_Homo sapiens_hsa04540 | 1.22165546 |
| 36 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.20858027 |
| 37 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.18470915 |
| 38 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.18093160 |
| 39 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.17558157 |
| 40 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.17011822 |
| 41 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.16057416 |
| 42 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.06273327 |
| 43 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.05888016 |
| 44 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.03599913 |
| 45 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.01440200 |
| 46 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.97022986 |
| 47 | Alzheimers disease_Homo sapiens_hsa05010 | 0.96418591 |
| 48 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.95963080 |
| 49 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.95479706 |
| 50 | Axon guidance_Homo sapiens_hsa04360 | 0.95234067 |
| 51 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.93155054 |
| 52 | Melanogenesis_Homo sapiens_hsa04916 | 0.84814508 |
| 53 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.83387327 |
| 54 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.82150326 |
| 55 | Glioma_Homo sapiens_hsa05214 | 0.78412262 |
| 56 | Circadian rhythm_Homo sapiens_hsa04710 | 0.77262601 |
| 57 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.76079949 |
| 58 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.72171221 |
| 59 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.70069710 |
| 60 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.69325830 |
| 61 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.69295944 |
| 62 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.67144787 |
| 63 | Parkinsons disease_Homo sapiens_hsa05012 | 0.63831649 |
| 64 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.63013787 |
| 65 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.62780152 |
| 66 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.62594180 |
| 67 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.60164535 |
| 68 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.60116001 |
| 69 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.60054414 |
| 70 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.57661358 |
| 71 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.57113289 |
| 72 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.57025625 |
| 73 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.56750512 |
| 74 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.49107997 |
| 75 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.49046436 |
| 76 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.48667707 |
| 77 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.48236222 |
| 78 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.48193856 |
| 79 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.46997168 |
| 80 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.46863152 |
| 81 | Huntingtons disease_Homo sapiens_hsa05016 | 0.45156936 |
| 82 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.44802119 |
| 83 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.43076058 |
| 84 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.42818793 |
| 85 | Alcoholism_Homo sapiens_hsa05034 | 0.41297569 |
| 86 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.41218925 |
| 87 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.41202407 |
| 88 | Mineral absorption_Homo sapiens_hsa04978 | 0.38636210 |
| 89 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.37672452 |
| 90 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.36195465 |
| 91 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.35626395 |
| 92 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.35380516 |
| 93 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.33932690 |
| 94 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.33103013 |
| 95 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.32927229 |
| 96 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.32346174 |
| 97 | Bile secretion_Homo sapiens_hsa04976 | 0.31066274 |
| 98 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.30206193 |
| 99 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.30113394 |
| 100 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.29968612 |
| 101 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.28939771 |
| 102 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.28035412 |
| 103 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.27423033 |
| 104 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.27362639 |
| 105 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.25707116 |
| 106 | * Endocytosis_Homo sapiens_hsa04144 | 0.25603333 |
| 107 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.24338235 |
| 108 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.23424179 |
| 109 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.21580201 |
| 110 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.20961396 |
| 111 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.20534615 |
| 112 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.18687819 |
| 113 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.18458711 |
| 114 | Histidine metabolism_Homo sapiens_hsa00340 | 0.17453397 |
| 115 | Prion diseases_Homo sapiens_hsa05020 | 0.17042976 |
| 116 | Tight junction_Homo sapiens_hsa04530 | 0.16082144 |
| 117 | Phagosome_Homo sapiens_hsa04145 | 0.15123728 |

