SH3GL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.90426310
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.86312124
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.46742491
4vocalization behavior (GO:0071625)5.28969921
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27811482
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.16890247
7glutamate secretion (GO:0014047)5.14892291
8synaptic vesicle maturation (GO:0016188)5.12613114
9protein localization to synapse (GO:0035418)5.09888616
10regulation of synaptic vesicle exocytosis (GO:2000300)5.09436862
11locomotory exploration behavior (GO:0035641)4.86451086
12glutamate receptor signaling pathway (GO:0007215)4.78363574
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.75834863
14neuronal action potential propagation (GO:0019227)4.72951009
15gamma-aminobutyric acid signaling pathway (GO:0007214)4.71533267
16G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.69710299
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.62846701
18regulation of glutamate receptor signaling pathway (GO:1900449)4.57732170
19neuron cell-cell adhesion (GO:0007158)4.57668087
20L-amino acid import (GO:0043092)4.54713882
21cellular potassium ion homeostasis (GO:0030007)4.54441772
22regulation of synaptic vesicle transport (GO:1902803)4.46977125
23neuron-neuron synaptic transmission (GO:0007270)4.40355247
24synaptic transmission, glutamatergic (GO:0035249)4.39043543
25positive regulation of synapse maturation (GO:0090129)4.36015994
26neurotransmitter secretion (GO:0007269)4.30148271
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.30056505
28regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.18615986
29neurotransmitter-gated ion channel clustering (GO:0072578)4.05739224
30exploration behavior (GO:0035640)4.00496284
31amino acid import (GO:0043090)3.98417335
32potassium ion import (GO:0010107)3.95288621
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94524266
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91950341
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.89549443
36long-term memory (GO:0007616)3.87927071
37regulation of neuronal synaptic plasticity (GO:0048168)3.86057204
38neuronal ion channel clustering (GO:0045161)3.83122907
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.82955928
40regulation of postsynaptic membrane potential (GO:0060078)3.79955112
41long-term synaptic potentiation (GO:0060291)3.78024757
42layer formation in cerebral cortex (GO:0021819)3.77284602
43positive regulation of membrane potential (GO:0045838)3.75515358
44cerebellar granule cell differentiation (GO:0021707)3.73142916
45neurotransmitter transport (GO:0006836)3.72645140
46cellular sodium ion homeostasis (GO:0006883)3.72192246
47cerebellar Purkinje cell differentiation (GO:0021702)3.71911738
48sodium ion export (GO:0071436)3.71179364
49response to pheromone (GO:0019236)3.70976897
50axon ensheathment in central nervous system (GO:0032291)3.69774046
51central nervous system myelination (GO:0022010)3.69774046
52negative regulation of dendrite morphogenesis (GO:0050774)3.69543581
53* synaptic vesicle endocytosis (GO:0048488)3.67030000
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66271006
55regulation of neurotransmitter secretion (GO:0046928)3.63789537
56response to histamine (GO:0034776)3.58769633
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.57316111
58transmission of nerve impulse (GO:0019226)3.54912574
59neuron recognition (GO:0008038)3.51831756
60regulation of synapse maturation (GO:0090128)3.51338828
61gamma-aminobutyric acid transport (GO:0015812)3.48412405
62regulation of synapse structural plasticity (GO:0051823)3.47633542
63regulation of vesicle fusion (GO:0031338)3.46973388
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.46858683
65presynaptic membrane assembly (GO:0097105)3.46448959
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.44634228
67innervation (GO:0060384)3.44621396
68regulation of synaptic plasticity (GO:0048167)3.42372179
69behavioral response to cocaine (GO:0048148)3.40861336
70long term synaptic depression (GO:0060292)3.40104611
71neuromuscular process controlling balance (GO:0050885)3.40000559
72neurotransmitter uptake (GO:0001504)3.38002837
73membrane hyperpolarization (GO:0060081)3.37431670
74dendritic spine morphogenesis (GO:0060997)3.35960053
75auditory behavior (GO:0031223)3.35791506
76regulation of neurotransmitter transport (GO:0051588)3.35278725
77presynaptic membrane organization (GO:0097090)3.34805841
78positive regulation of dendritic spine morphogenesis (GO:0061003)3.34385971
79cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.32900691
80regulation of ARF protein signal transduction (GO:0032012)3.32211265
81regulation of dendritic spine morphogenesis (GO:0061001)3.30756523
82regulation of neurotransmitter levels (GO:0001505)3.28710935
83regulation of voltage-gated calcium channel activity (GO:1901385)3.28242343
84positive regulation of neurotransmitter secretion (GO:0001956)3.27884737
85membrane depolarization (GO:0051899)3.27483372
86behavioral fear response (GO:0001662)3.24992902
87behavioral defense response (GO:0002209)3.24992902
88postsynaptic membrane organization (GO:0001941)3.24524562
89mating behavior (GO:0007617)3.23984782
90acidic amino acid transport (GO:0015800)3.22465583
91membrane depolarization during action potential (GO:0086010)3.21935007
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17971802
93proline transport (GO:0015824)3.17392538
94potassium ion homeostasis (GO:0055075)3.16828157
95neuromuscular process controlling posture (GO:0050884)3.13740400
96chemosensory behavior (GO:0007635)3.13729546
97fear response (GO:0042596)3.13646805
98synapse assembly (GO:0007416)3.13509328
99synaptic transmission (GO:0007268)3.12915664
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11676365
101righting reflex (GO:0060013)3.10895581
102positive regulation of neurotransmitter transport (GO:0051590)3.10664580
103dendritic spine organization (GO:0097061)3.08736323
104axonal fasciculation (GO:0007413)3.08389790
105regulation of exocytosis (GO:0017157)3.08224497
106learning (GO:0007612)3.07020920
107positive regulation of dendritic spine development (GO:0060999)3.06110389
108vesicle docking involved in exocytosis (GO:0006904)3.04060098
109C4-dicarboxylate transport (GO:0015740)3.03898864
110cerebellar Purkinje cell layer development (GO:0021680)3.01834323
111cell communication involved in cardiac conduction (GO:0086065)3.00986683
112* establishment of synaptic vesicle localization (GO:0097480)3.00728460
113* synaptic vesicle transport (GO:0048489)3.00728460
114cell communication by electrical coupling (GO:0010644)3.00568775
115regulation of calcium ion-dependent exocytosis (GO:0017158)3.00028172
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98831360
117adult walking behavior (GO:0007628)2.98499858
118regulation of synaptic transmission (GO:0050804)2.98462710
119positive regulation of synaptic transmission (GO:0050806)2.98191762
120detection of calcium ion (GO:0005513)2.92839905
121regulation of dendritic spine development (GO:0060998)2.90339164
122cell differentiation in hindbrain (GO:0021533)2.89477684
123activation of protein kinase A activity (GO:0034199)2.88720956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67232098
2GBX2_23144817_ChIP-Seq_PC3_Human4.05773802
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13048206
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08509213
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05496113
6REST_21632747_ChIP-Seq_MESCs_Mouse2.76051189
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65115583
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65115583
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62657473
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58726801
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54309277
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.47657136
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43430632
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43421544
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36759684
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.35362427
17DROSHA_22980978_ChIP-Seq_HELA_Human2.33771212
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.24205177
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.22657958
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20175237
21TAF15_26573619_Chip-Seq_HEK293_Human2.18311240
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.17700843
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15484468
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.14923558
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12034175
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00899757
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99133730
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93129204
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88533219
30AR_21572438_ChIP-Seq_LNCaP_Human1.86401584
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83895295
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81900267
33SMAD4_21799915_ChIP-Seq_A2780_Human1.78807850
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77591695
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71639078
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61163716
37P300_19829295_ChIP-Seq_ESCs_Human1.60686295
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57846255
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57418474
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55110483
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47703430
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.43114254
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41717336
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.40051379
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39579161
46* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38261531
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36691419
48VDR_22108803_ChIP-Seq_LS180_Human1.36633399
49ZNF274_21170338_ChIP-Seq_K562_Hela1.35664898
50AR_25329375_ChIP-Seq_VCAP_Human1.34295345
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.33340946
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33328585
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32661352
54STAT3_23295773_ChIP-Seq_U87_Human1.28779396
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.27872936
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.27533428
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26853831
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26833179
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26771985
60* FUS_26573619_Chip-Seq_HEK293_Human1.26457574
61RNF2_27304074_Chip-Seq_NSC_Mouse1.25495875
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25121067
63IGF1R_20145208_ChIP-Seq_DFB_Human1.24386379
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23889065
65* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22596972
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.20949112
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20404844
68TCF4_23295773_ChIP-Seq_U87_Human1.18801504
69AR_19668381_ChIP-Seq_PC3_Human1.17995778
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17588388
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16759690
72TET1_21490601_ChIP-Seq_MESCs_Mouse1.12093368
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11153385
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07510635
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07136513
76ER_23166858_ChIP-Seq_MCF-7_Human1.05394948
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05014402
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.04852952
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04783500
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.03932286
81* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03730315
82* NANOG_18555785_Chip-Seq_ESCs_Mouse1.03591786
83KDM2B_26808549_Chip-Seq_K562_Human1.03550140
84RUNX2_22187159_ChIP-Seq_PCA_Human1.03284288
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01280001
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00806760
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.00486115
88TP53_16413492_ChIP-PET_HCT116_Human0.98872184
89WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98295011
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97674135
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97674135
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95162090
93ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95011014
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94747842
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93849279
96JUN_21703547_ChIP-Seq_K562_Human0.93006799
97AHR_22903824_ChIP-Seq_MCF-7_Human0.92884051
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.92531286
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91780861
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91666152
101BCAT_22108803_ChIP-Seq_LS180_Human0.91446271
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91177932
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90811245
104GATA1_26923725_Chip-Seq_HPCs_Mouse0.90322451
105E2F1_18555785_Chip-Seq_ESCs_Mouse0.90221591
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90162638
107* SMAD3_21741376_ChIP-Seq_ESCs_Human0.90023124
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.89894200
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89884088
110DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88796323
111CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88652677
112SOX9_26525672_Chip-Seq_HEART_Mouse0.86176809
113ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83994755
114OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83598827
115TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82281482
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81737609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.78602256
2MP0003880_abnormal_central_pattern5.36377802
3MP0003635_abnormal_synaptic_transmissio4.06638245
4MP0009046_muscle_twitch3.46325559
5MP0009745_abnormal_behavioral_response3.40590566
6MP0004270_analgesia3.37294760
7MP0002064_seizures3.24495667
8MP0002063_abnormal_learning/memory/cond3.21617264
9MP0001968_abnormal_touch/_nociception3.11087307
10MP0002272_abnormal_nervous_system2.82725950
11MP0002572_abnormal_emotion/affect_behav2.81063996
12MP0001486_abnormal_startle_reflex2.65742804
13MP0005423_abnormal_somatic_nervous2.64976874
14MP0002734_abnormal_mechanical_nocicepti2.61515108
15MP0002736_abnormal_nociception_after2.55822480
16MP0001501_abnormal_sleep_pattern2.36935156
17MP0001440_abnormal_grooming_behavior2.31136472
18MP0002067_abnormal_sensory_capabilities2.25469250
19MP0002735_abnormal_chemical_nociception2.21634710
20MP0001984_abnormal_olfaction2.10155202
21MP0005551_abnormal_eye_electrophysiolog2.07703544
22MP0008569_lethality_at_weaning2.00410938
23MP0002184_abnormal_innervation1.97998737
24MP0001970_abnormal_pain_threshold1.88308881
25MP0002822_catalepsy1.85479843
26MP0002733_abnormal_thermal_nociception1.84469088
27MP0004924_abnormal_behavior1.72439962
28MP0005386_behavior/neurological_phenoty1.72439962
29MP0002557_abnormal_social/conspecific_i1.71462110
30MP0003879_abnormal_hair_cell1.71133990
31MP0000778_abnormal_nervous_system1.70841449
32MP0006276_abnormal_autonomic_nervous1.68469655
33MP0003329_amyloid_beta_deposits1.68437043
34MP0001502_abnormal_circadian_rhythm1.63244221
35MP0001188_hyperpigmentation1.54619896
36MP0004811_abnormal_neuron_physiology1.53850855
37MP0003123_paternal_imprinting1.51325814
38MP0000955_abnormal_spinal_cord1.49906135
39MP0004142_abnormal_muscle_tone1.48411273
40MP0002882_abnormal_neuron_morphology1.47511921
41MP0008877_abnormal_DNA_methylation1.46944178
42MP0001529_abnormal_vocalization1.45420501
43MP0005646_abnormal_pituitary_gland1.45193121
44MP0004145_abnormal_muscle_electrophysio1.44818736
45MP0002066_abnormal_motor_capabilities/c1.42285095
46MP0002909_abnormal_adrenal_gland1.41359189
47MP0009780_abnormal_chondrocyte_physiolo1.41339068
48MP0003787_abnormal_imprinting1.40120816
49MP0010386_abnormal_urinary_bladder1.35512752
50MP0006072_abnormal_retinal_apoptosis1.33792509
51MP0001905_abnormal_dopamine_level1.32875480
52MP0004742_abnormal_vestibular_system1.29173397
53MP0004885_abnormal_endolymph1.28115293
54MP0002229_neurodegeneration1.24503367
55MP0003633_abnormal_nervous_system1.24348435
56MP0004147_increased_porphyrin_level1.24179536
57MP0002090_abnormal_vision1.22554740
58MP0004858_abnormal_nervous_system1.20700561
59MP0005645_abnormal_hypothalamus_physiol1.11218919
60MP0003631_nervous_system_phenotype1.09158946
61MP0002152_abnormal_brain_morphology1.06816244
62MP0005394_taste/olfaction_phenotype1.03304375
63MP0005499_abnormal_olfactory_system1.03304375
64MP0008872_abnormal_physiological_respon1.03159554
65MP0001963_abnormal_hearing_physiology1.00832322
66MP0003122_maternal_imprinting1.00156412
67MP0002837_dystrophic_cardiac_calcinosis0.99571988
68MP0005253_abnormal_eye_physiology0.99510083
69MP0002752_abnormal_somatic_nervous0.99462092
70MP0004215_abnormal_myocardial_fiber0.91352500
71MP0002069_abnormal_eating/drinking_beha0.89636489
72MP0006292_abnormal_olfactory_placode0.89604722
73MP0001986_abnormal_taste_sensitivity0.87690508
74MP0000631_abnormal_neuroendocrine_gland0.87156342
75MP0000751_myopathy0.86309512
76MP0003632_abnormal_nervous_system0.82271258
77MP0002638_abnormal_pupillary_reflex0.81761103
78MP0008874_decreased_physiological_sensi0.81572840
79MP0003121_genomic_imprinting0.80873535
80MP0003634_abnormal_glial_cell0.80822084
81MP0004085_abnormal_heartbeat0.79890484
82MP0004233_abnormal_muscle_weight0.78959255
83MP0000920_abnormal_myelination0.78363087
84MP0005535_abnormal_body_temperature0.77511669
85MP0004043_abnormal_pH_regulation0.77194870
86MP0001485_abnormal_pinna_reflex0.76306249
87MP0004484_altered_response_of0.73918733
88MP0000013_abnormal_adipose_tissue0.73633928
89MP0001348_abnormal_lacrimal_gland0.73208065
90MP0003172_abnormal_lysosome_physiology0.72308971
91MP0001664_abnormal_digestion0.72265714
92MP0005409_darkened_coat_color0.71922997
93MP0002876_abnormal_thyroid_physiology0.71108034
94MP0005167_abnormal_blood-brain_barrier0.67843991
95MP0001177_atelectasis0.67787612
96MP0003075_altered_response_to0.66862897
97MP0005195_abnormal_posterior_eye0.66593609
98MP0000026_abnormal_inner_ear0.64552212
99MP0000604_amyloidosis0.63989611
100MP0003137_abnormal_impulse_conducting0.61806667
101MP0005171_absent_coat_pigmentation0.61004007
102MP0003283_abnormal_digestive_organ0.57484335
103MP0003690_abnormal_glial_cell0.56442147
104MP0010768_mortality/aging0.54735825
105MP0010234_abnormal_vibrissa_follicle0.54311799
106MP0001346_abnormal_lacrimal_gland0.53912712
107MP0001943_abnormal_respiration0.52924748
108MP0003956_abnormal_body_size0.52882428
109MP0010769_abnormal_survival0.51665785
110MP0005623_abnormal_meninges_morphology0.50905664
111MP0010770_preweaning_lethality0.50710390
112MP0002082_postnatal_lethality0.50710390
113MP0003861_abnormal_nervous_system0.49927641
114MP0002653_abnormal_ependyma_morphology0.48124935
115MP0001944_abnormal_pancreas_morphology0.48054222
116MP0000639_abnormal_adrenal_gland0.47541415
117MP0001765_abnormal_ion_homeostasis0.44766509

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.89953819
2Myokymia (HP:0002411)5.86814362
3Focal seizures (HP:0007359)5.71823493
4Epileptic encephalopathy (HP:0200134)5.59799753
5Visual hallucinations (HP:0002367)5.43294638
6Febrile seizures (HP:0002373)5.34611670
7Atonic seizures (HP:0010819)5.29019079
8Absence seizures (HP:0002121)4.94115170
9Progressive cerebellar ataxia (HP:0002073)4.91999590
10Dialeptic seizures (HP:0011146)4.49431964
11Generalized tonic-clonic seizures (HP:0002069)4.13317042
12Congenital stationary night blindness (HP:0007642)3.88314965
13Gaze-evoked nystagmus (HP:0000640)3.83881446
14Action tremor (HP:0002345)3.81876597
15Broad-based gait (HP:0002136)3.63032021
16Hyperventilation (HP:0002883)3.62333394
17Dysdiadochokinesis (HP:0002075)3.48072535
18Cerebral hypomyelination (HP:0006808)3.46943276
19Papilledema (HP:0001085)3.35399746
20Supranuclear gaze palsy (HP:0000605)3.29253430
21Dysmetria (HP:0001310)3.21102212
22Truncal ataxia (HP:0002078)3.20513561
23Tetraplegia (HP:0002445)3.13730472
24Hemiparesis (HP:0001269)3.11532816
25Poor eye contact (HP:0000817)2.98662468
26Depression (HP:0000716)2.92396269
27Amblyopia (HP:0000646)2.90311245
28Scanning speech (HP:0002168)2.86875325
29Annular pancreas (HP:0001734)2.86740674
30Akinesia (HP:0002304)2.85693161
31Impaired smooth pursuit (HP:0007772)2.83393065
32Anxiety (HP:0000739)2.83223300
33Drooling (HP:0002307)2.77562323
34Excessive salivation (HP:0003781)2.77562323
35Impaired vibration sensation in the lower limbs (HP:0002166)2.76429339
36Central scotoma (HP:0000603)2.74599583
37Genetic anticipation (HP:0003743)2.71742693
38Epileptiform EEG discharges (HP:0011182)2.71655396
39Abnormality of macular pigmentation (HP:0008002)2.69277852
40Obstructive sleep apnea (HP:0002870)2.68168986
41Urinary bladder sphincter dysfunction (HP:0002839)2.67921718
42Abnormal eating behavior (HP:0100738)2.67817209
43Ankle clonus (HP:0011448)2.67442310
44Abnormality of binocular vision (HP:0011514)2.67280887
45Diplopia (HP:0000651)2.67280887
46Impaired social interactions (HP:0000735)2.62847068
47Abnormal social behavior (HP:0012433)2.62847068
48Absent speech (HP:0001344)2.62009865
49Craniofacial dystonia (HP:0012179)2.61799533
50Mutism (HP:0002300)2.61440857
51Dysmetric saccades (HP:0000641)2.58771015
52Postural instability (HP:0002172)2.58613296
53EEG with generalized epileptiform discharges (HP:0011198)2.57283889
54Cerebral inclusion bodies (HP:0100314)2.56269215
55Abnormality of ocular smooth pursuit (HP:0000617)2.55104380
56Sleep apnea (HP:0010535)2.52637325
57Status epilepticus (HP:0002133)2.41113206
58Clonus (HP:0002169)2.40635558
59Neurofibrillary tangles (HP:0002185)2.40441087
60Gait imbalance (HP:0002141)2.38929222
61Spastic gait (HP:0002064)2.35819764
62Abnormality of the lower motor neuron (HP:0002366)2.34036393
63Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32833693
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.32833693
65Progressive inability to walk (HP:0002505)2.30122780
66Apathy (HP:0000741)2.29988461
67Intention tremor (HP:0002080)2.27666458
68Inability to walk (HP:0002540)2.27427812
69Fetal akinesia sequence (HP:0001989)2.27175110
70Increased circulating renin level (HP:0000848)2.26223999
71Bradykinesia (HP:0002067)2.24586837
72Choreoathetosis (HP:0001266)2.23411123
73Generalized myoclonic seizures (HP:0002123)2.21619600
74Hypsarrhythmia (HP:0002521)2.20144377
75Postural tremor (HP:0002174)2.18362029
76Rigidity (HP:0002063)2.17771863
77Abnormality of the corticospinal tract (HP:0002492)2.16409778
78Hemiplegia (HP:0002301)2.16208439
79CNS hypomyelination (HP:0003429)2.14771150
80Stereotypic behavior (HP:0000733)2.14288622
81Delusions (HP:0000746)2.13382932
82Congenital primary aphakia (HP:0007707)2.11080622
83Ventricular fibrillation (HP:0001663)2.08761892
84Diminished motivation (HP:0000745)2.08165094
85Hypoglycemic seizures (HP:0002173)2.06968544
86Spastic tetraparesis (HP:0001285)2.05176656
87Medial flaring of the eyebrow (HP:0010747)2.05153578
88Hyperinsulinemic hypoglycemia (HP:0000825)2.02142391
89Termporal pattern (HP:0011008)2.00982728
90Insidious onset (HP:0003587)2.00982728
91Urinary urgency (HP:0000012)2.00742272
92Impaired vibratory sensation (HP:0002495)2.00663955
93Decreased central vision (HP:0007663)2.00502960
94Peripheral hypomyelination (HP:0007182)2.00260563
95Pheochromocytoma (HP:0002666)1.99730707
96Morphological abnormality of the pyramidal tract (HP:0002062)1.99031740
97Gait ataxia (HP:0002066)1.98390490
98Incomplete penetrance (HP:0003829)1.97599984
99Polyphagia (HP:0002591)1.97251012
100Protruding tongue (HP:0010808)1.96718517
101Nephrogenic diabetes insipidus (HP:0009806)1.95131348
102Lower limb asymmetry (HP:0100559)1.94429604
103Rapidly progressive (HP:0003678)1.90899040
104Blue irides (HP:0000635)1.88791596
105Specific learning disability (HP:0001328)1.88358283
106Retinal dysplasia (HP:0007973)1.88240710
107Abnormality of salivation (HP:0100755)1.88222663
108Lower limb muscle weakness (HP:0007340)1.86212368
109Bundle branch block (HP:0011710)1.84214366
110Torticollis (HP:0000473)1.83553203
111Abnormality of saccadic eye movements (HP:0000570)1.81260253
112Spastic tetraplegia (HP:0002510)1.80928734
113Psychosis (HP:0000709)1.79101228
114Limb ataxia (HP:0002070)1.78849563
115Focal dystonia (HP:0004373)1.78177037
116Neuroendocrine neoplasm (HP:0100634)1.75616438
117Diminished movement (HP:0002374)1.74400927
118Muscular hypotonia of the trunk (HP:0008936)1.74106733
119Paraplegia (HP:0010550)1.74069949
120Absent/shortened dynein arms (HP:0200106)1.73331182
121Dynein arm defect of respiratory motile cilia (HP:0012255)1.73331182
122Prolonged QT interval (HP:0001657)1.72142034
123Scotoma (HP:0000575)1.72064431
124Esotropia (HP:0000565)1.70922432
125Neuronal loss in central nervous system (HP:0002529)1.70617271
126Horizontal nystagmus (HP:0000666)1.70528369
127Genital tract atresia (HP:0001827)1.69733223
128Agitation (HP:0000713)1.68760248
129Widely spaced teeth (HP:0000687)1.68036054
130Limb dystonia (HP:0002451)1.67939556
131Choroideremia (HP:0001139)1.67662287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.13558344
2EPHA44.03184011
3MAP3K43.47653798
4MAP3K93.41811588
5MAP2K72.92764765
6CASK2.84216438
7NEK12.68225803
8MINK12.57711367
9MAP3K122.52781627
10RIPK42.52566217
11MARK12.36076613
12DAPK22.32486837
13PAK62.29697450
14MAP2K42.08089085
15CDK191.93507620
16PLK21.93042463
17PNCK1.91886017
18TNIK1.75953587
19GRK51.74389461
20PRPF4B1.74012498
21NTRK21.64644369
22KSR21.59091157
23DAPK11.56623440
24ARAF1.47198434
25CAMKK11.46221942
26CAMKK21.42235248
27CDK51.41404244
28KSR11.38790681
29OXSR11.37677229
30MAP3K131.33929167
31STK381.31341105
32SIK21.31101176
33MAPK131.31018305
34FGFR21.28547901
35NTRK11.27870346
36PRKCG1.26473053
37FES1.25318604
38FRK1.23082346
39BMPR21.23003304
40PRKD31.17532069
41NME11.15148928
42CAMK2A1.13174486
43RIPK11.09352988
44DYRK1A1.01121314
45UHMK11.00562869
46PTK2B0.98541183
47CAMK10.96335963
48CAMK2B0.96043785
49SGK2230.94327796
50SGK4940.94327796
51CDK180.91106794
52CDK140.89227482
53CDK150.88998921
54FGR0.86248667
55ALK0.78312825
56CDK11A0.78246821
57CAMK2D0.77765717
58PINK10.77341882
59TNK20.77059478
60PHKG10.76245354
61PHKG20.76245354
62AKT30.75114677
63STK110.73762608
64LIMK10.73721222
65WNK10.72923592
66CCNB10.69791871
67SGK20.69575120
68TYRO30.69477071
69RAF10.69207139
70SGK10.65498193
71PRKCE0.63698204
72FER0.63658880
73MAPK120.62709778
74PAK30.62383294
75TESK10.61983201
76SIK30.60785983
77MAP3K20.59655433
78CAMK1G0.59645456
79CAMK2G0.57363769
80MAP3K60.57300029
81MAP4K20.55215184
82NEK60.54237573
83BRSK10.53679793
84PRKCH0.53571611
85GRK70.50858724
86STK390.50801113
87CDK30.49323536
88MARK20.49093550
89LATS20.49007972
90RET0.47532832
91BCR0.47468124
92DAPK30.46754111
93WNK30.46394656
94PDK10.45872248
95CSNK1G20.45099128
96SGK30.44212976
97RPS6KA30.44105790
98BRAF0.43011743
99MAP3K10.42147387
100PDPK10.41863461
101CAMK40.41485289
102MAPK100.41418468
103LMTK20.40310049
104PRKCZ0.39968760
105ADRBK20.39769419
106FYN0.39045938
107MAP3K70.38529925
108IRAK20.38121228
109PRKG10.37501464
110PRKCA0.37493972
111PRKACA0.37452148
112PKN10.36975668
113CDC42BPA0.36140045
114CSNK1G30.35901647
115MAPKAPK50.35573553
116CSNK1A10.35418166
117PRKG20.33417346
118ROCK10.30325406
119MAP2K60.30313641
120CSNK1D0.30065091

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.43339634
2Synaptic vesicle cycle_Homo sapiens_hsa047213.61404761
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.08951246
4GABAergic synapse_Homo sapiens_hsa047272.94569178
5Morphine addiction_Homo sapiens_hsa050322.77794884
6Circadian entrainment_Homo sapiens_hsa047132.76523999
7Glutamatergic synapse_Homo sapiens_hsa047242.69410909
8Long-term potentiation_Homo sapiens_hsa047202.61329360
9Olfactory transduction_Homo sapiens_hsa047402.58065074
10Amphetamine addiction_Homo sapiens_hsa050312.36817976
11Salivary secretion_Homo sapiens_hsa049702.30135758
12Taste transduction_Homo sapiens_hsa047422.13987426
13Collecting duct acid secretion_Homo sapiens_hsa049662.12527104
14Dopaminergic synapse_Homo sapiens_hsa047282.10147716
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05161605
16Insulin secretion_Homo sapiens_hsa049112.05081456
17Vitamin B6 metabolism_Homo sapiens_hsa007501.95946274
18Renin secretion_Homo sapiens_hsa049241.87673821
19Serotonergic synapse_Homo sapiens_hsa047261.86826711
20Long-term depression_Homo sapiens_hsa047301.81470501
21Cholinergic synapse_Homo sapiens_hsa047251.80334903
22Gastric acid secretion_Homo sapiens_hsa049711.80008822
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75315827
24Oxytocin signaling pathway_Homo sapiens_hsa049211.69278764
25Calcium signaling pathway_Homo sapiens_hsa040201.65825208
26Phototransduction_Homo sapiens_hsa047441.59869127
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53260613
28Cardiac muscle contraction_Homo sapiens_hsa042601.41219518
29Cocaine addiction_Homo sapiens_hsa050301.34750246
30GnRH signaling pathway_Homo sapiens_hsa049121.34164957
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29427866
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26533424
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26365858
34cAMP signaling pathway_Homo sapiens_hsa040241.22657744
35Gap junction_Homo sapiens_hsa045401.22165546
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20858027
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18470915
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18093160
39Vibrio cholerae infection_Homo sapiens_hsa051101.17558157
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17011822
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16057416
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06273327
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05888016
44Oxidative phosphorylation_Homo sapiens_hsa001901.03599913
45Type II diabetes mellitus_Homo sapiens_hsa049301.01440200
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.97022986
47Alzheimers disease_Homo sapiens_hsa050100.96418591
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95963080
49Estrogen signaling pathway_Homo sapiens_hsa049150.95479706
50Axon guidance_Homo sapiens_hsa043600.95234067
51Pancreatic secretion_Homo sapiens_hsa049720.93155054
52Melanogenesis_Homo sapiens_hsa049160.84814508
53ErbB signaling pathway_Homo sapiens_hsa040120.83387327
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.82150326
55Glioma_Homo sapiens_hsa052140.78412262
56Circadian rhythm_Homo sapiens_hsa047100.77262601
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76079949
58Oocyte meiosis_Homo sapiens_hsa041140.72171221
59Thyroid hormone synthesis_Homo sapiens_hsa049180.70069710
60Dilated cardiomyopathy_Homo sapiens_hsa054140.69325830
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69295944
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.67144787
63Parkinsons disease_Homo sapiens_hsa050120.63831649
64Choline metabolism in cancer_Homo sapiens_hsa052310.63013787
65MAPK signaling pathway_Homo sapiens_hsa040100.62780152
66Inositol phosphate metabolism_Homo sapiens_hsa005620.62594180
67Butanoate metabolism_Homo sapiens_hsa006500.60164535
68Arginine biosynthesis_Homo sapiens_hsa002200.60116001
69Dorso-ventral axis formation_Homo sapiens_hsa043200.60054414
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57661358
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57113289
72Nitrogen metabolism_Homo sapiens_hsa009100.57025625
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56750512
74Rheumatoid arthritis_Homo sapiens_hsa053230.49107997
75Glucagon signaling pathway_Homo sapiens_hsa049220.49046436
76Ras signaling pathway_Homo sapiens_hsa040140.48667707
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48236222
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48193856
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46997168
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46863152
81Huntingtons disease_Homo sapiens_hsa050160.45156936
82African trypanosomiasis_Homo sapiens_hsa051430.44802119
83VEGF signaling pathway_Homo sapiens_hsa043700.43076058
84Arginine and proline metabolism_Homo sapiens_hsa003300.42818793
85Alcoholism_Homo sapiens_hsa050340.41297569
86Regulation of autophagy_Homo sapiens_hsa041400.41218925
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.41202407
88Mineral absorption_Homo sapiens_hsa049780.38636210
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37672452
90Rap1 signaling pathway_Homo sapiens_hsa040150.36195465
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35626395
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35380516
93Type I diabetes mellitus_Homo sapiens_hsa049400.33932690
94Wnt signaling pathway_Homo sapiens_hsa043100.33103013
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32927229
96Folate biosynthesis_Homo sapiens_hsa007900.32346174
97Bile secretion_Homo sapiens_hsa049760.31066274
98Fatty acid biosynthesis_Homo sapiens_hsa000610.30206193
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30113394
100AMPK signaling pathway_Homo sapiens_hsa041520.29968612
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.28939771
102Ovarian steroidogenesis_Homo sapiens_hsa049130.28035412
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27423033
104mTOR signaling pathway_Homo sapiens_hsa041500.27362639
105Renal cell carcinoma_Homo sapiens_hsa052110.25707116
106* Endocytosis_Homo sapiens_hsa041440.25603333
107beta-Alanine metabolism_Homo sapiens_hsa004100.24338235
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23424179
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21580201
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20961396
111Chemokine signaling pathway_Homo sapiens_hsa040620.20534615
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.18687819
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18458711
114Histidine metabolism_Homo sapiens_hsa003400.17453397
115Prion diseases_Homo sapiens_hsa050200.17042976
116Tight junction_Homo sapiens_hsa045300.16082144
117Phagosome_Homo sapiens_hsa041450.15123728

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