SH3GL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.70616523
2central nervous system myelination (GO:0022010)9.70616523
3axon ensheathment (GO:0008366)7.01735978
4ensheathment of neurons (GO:0007272)7.01735978
5myelination (GO:0042552)7.00817362
6fatty acid elongation (GO:0030497)6.74397161
7negative regulation of neurotransmitter secretion (GO:0046929)5.71873133
8long-chain fatty acid biosynthetic process (GO:0042759)5.51822327
9positive regulation of cell size (GO:0045793)5.31521990
10arginine catabolic process (GO:0006527)5.08808684
11sperm motility (GO:0030317)4.84675511
12diaphragm development (GO:0060539)4.76619460
13negative regulation of neurotransmitter transport (GO:0051589)4.74644663
14regulation of synaptic vesicle exocytosis (GO:2000300)4.73060928
15glycerophospholipid catabolic process (GO:0046475)4.72725825
16positive regulation of guanylate cyclase activity (GO:0031284)4.71020965
17protein targeting to Golgi (GO:0000042)4.65079515
18regulation of synaptic vesicle transport (GO:1902803)4.60854229
19presynaptic membrane assembly (GO:0097105)4.55505846
20skeletal muscle organ development (GO:0060538)4.55391467
21oligodendrocyte differentiation (GO:0048709)4.51564383
22negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.49591838
23establishment of protein localization to Golgi (GO:0072600)4.47204978
24cholesterol biosynthetic process (GO:0006695)4.40851613
25regulation of neurotransmitter uptake (GO:0051580)4.39983951
26presynaptic membrane organization (GO:0097090)4.34947626
27transmission of nerve impulse (GO:0019226)4.31569798
28retrograde transport, vesicle recycling within Golgi (GO:0000301)4.30379698
29regulation of guanylate cyclase activity (GO:0031282)4.27754659
30astrocyte development (GO:0014002)4.23364621
31negative regulation of vascular permeability (GO:0043116)4.23266398
32protein polyglutamylation (GO:0018095)4.21501624
33regulation of cilium movement (GO:0003352)4.21280471
34positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.19993244
35substantia nigra development (GO:0021762)4.14722201
36asymmetric protein localization (GO:0008105)4.07782062
37regulation of collateral sprouting (GO:0048670)4.05222781
38glutamate secretion (GO:0014047)4.01938569
39fusion of sperm to egg plasma membrane (GO:0007342)4.01621781
40photoreceptor cell differentiation (GO:0046530)4.00944685
41eye photoreceptor cell differentiation (GO:0001754)4.00944685
42synaptic vesicle maturation (GO:0016188)3.95161682
43calcium ion-dependent exocytosis (GO:0017156)3.93922931
44apical protein localization (GO:0045176)3.91585466
45establishment of mitochondrion localization (GO:0051654)3.91444277
46neuron cell-cell adhesion (GO:0007158)3.89290774
47sterol biosynthetic process (GO:0016126)3.86764803
48adhesion of symbiont to host cell (GO:0044650)3.85330513
49virion attachment to host cell (GO:0019062)3.85330513
50synaptic vesicle exocytosis (GO:0016079)3.83532416
51myelin maintenance (GO:0043217)3.80607819
52sperm capacitation (GO:0048240)3.80567015
53negative regulation of potassium ion transport (GO:0043267)3.80220609
54peripheral nervous system axon ensheathment (GO:0032292)3.79630950
55myelination in peripheral nervous system (GO:0022011)3.79630950
56positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.77534852
57peptidyl-tyrosine autophosphorylation (GO:0038083)3.75193957
58arginine metabolic process (GO:0006525)3.74771013
59positive regulation of action potential (GO:0045760)3.72967424
60L-amino acid import (GO:0043092)3.72959379
61epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.71108921
62response to redox state (GO:0051775)3.71057216
63microtubule depolymerization (GO:0007019)3.68894998
64chromatin silencing (GO:0006342)3.66905159
65neuronal ion channel clustering (GO:0045161)3.64152624
66cellular response to epinephrine stimulus (GO:0071872)3.60654896
67protein localization to Golgi apparatus (GO:0034067)3.54882649
68regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.53618480
69cerebral cortex radially oriented cell migration (GO:0021799)3.53602110
70positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.52402821
71negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.51471904
72cellular protein complex localization (GO:0034629)3.51345901
73negative regulation of axonogenesis (GO:0050771)3.50112934
74spermatid development (GO:0007286)3.44405036
75creatine metabolic process (GO:0006600)3.43122462
76regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.42580246
77regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41264410
78long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.40905597
79negative regulation of protein localization to cell surface (GO:2000009)3.37901605
80adult walking behavior (GO:0007628)3.37025597
81neurotransmitter catabolic process (GO:0042135)3.35671712
82synaptic vesicle docking involved in exocytosis (GO:0016081)3.35015402
83isoprenoid biosynthetic process (GO:0008299)3.34938451
84limb bud formation (GO:0060174)3.32496331
85regulation of nuclear cell cycle DNA replication (GO:0033262)3.32080800
86negative regulation of calcium ion transport into cytosol (GO:0010523)3.30634613
87axonal fasciculation (GO:0007413)3.27700347
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26210706
89neuronal action potential propagation (GO:0019227)3.23386327
90exogenous drug catabolic process (GO:0042738)3.23208341
91regulation of neurotransmitter transport (GO:0051588)3.22217251
92regulation of microtubule-based movement (GO:0060632)3.18400450
93positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.18051732
94pyrimidine nucleoside salvage (GO:0043097)3.17811863
95pyrimidine-containing compound salvage (GO:0008655)3.17811863
96negative regulation of axon extension (GO:0030517)3.14965276
97plasma membrane fusion (GO:0045026)3.14871157
98protein palmitoylation (GO:0018345)3.14633113
99response to epinephrine (GO:0071871)3.14578164
100regulation of glutamate receptor signaling pathway (GO:1900449)3.12492705
101membrane tubulation (GO:0097320)3.10676654
102positive regulation of oligodendrocyte differentiation (GO:0048714)3.08465774
103ionotropic glutamate receptor signaling pathway (GO:0035235)3.08169278
104long-term synaptic potentiation (GO:0060291)3.07503576
105nerve growth factor signaling pathway (GO:0038180)3.07262542
106long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.06466103
107cerebellar granule cell differentiation (GO:0021707)3.05795714
108substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.05734472
109substrate-independent telencephalic tangential migration (GO:0021826)3.05734472
110dendritic spine morphogenesis (GO:0060997)3.05599435
111regulation of voltage-gated calcium channel activity (GO:1901385)3.03753948
112import into cell (GO:0098657)3.00906942
113positive regulation of cGMP biosynthetic process (GO:0030828)3.00763276
114axonemal dynein complex assembly (GO:0070286)3.00315640
115magnesium ion transport (GO:0015693)2.99938601
116peripheral nervous system development (GO:0007422)2.99145627
117membrane assembly (GO:0071709)2.97810623
118protein complex localization (GO:0031503)2.97388162
119response to hepatocyte growth factor (GO:0035728)2.97008735
120cellular response to hepatocyte growth factor stimulus (GO:0035729)2.97008735
121membrane depolarization during action potential (GO:0086010)2.95130239
122positive regulation of sodium ion transmembrane transport (GO:1902307)2.95081320
123positive regulation of dendritic spine development (GO:0060999)2.93390676
124glycosylceramide metabolic process (GO:0006677)2.92550007
125fatty-acyl-CoA biosynthetic process (GO:0046949)2.90420210
126spermatid nucleus differentiation (GO:0007289)2.89683246
127Rap protein signal transduction (GO:0032486)2.89281147
128synaptic transmission, glutamatergic (GO:0035249)2.88804627
129epithelial cilium movement (GO:0003351)2.87684812
130negative regulation of inclusion body assembly (GO:0090084)2.86344403
131regulation of neurotransmitter secretion (GO:0046928)2.85650831
132neurotransmitter secretion (GO:0007269)2.85485327
133postsynaptic membrane organization (GO:0001941)2.85228387
134protein localization to synapse (GO:0035418)2.84458604
135cellular response to monoamine stimulus (GO:0071868)2.83921574
136cellular response to catecholamine stimulus (GO:0071870)2.83921574
137positive regulation of Rab GTPase activity (GO:0032851)2.83639353
138regulation of Rab GTPase activity (GO:0032313)2.83639353
139neural nucleus development (GO:0048857)2.83322012
140pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.83082404
141UMP metabolic process (GO:0046049)2.83082404
142pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.83082404
143UMP biosynthetic process (GO:0006222)2.83082404
144regulation of cGMP biosynthetic process (GO:0030826)2.82398119
145neuron recognition (GO:0008038)2.82339559
146adhesion of symbiont to host (GO:0044406)2.81711203
147positive regulation of signal transduction by p53 class mediator (GO:1901798)2.81548646
148neurotransmitter transport (GO:0006836)2.81397880
149response to methylmercury (GO:0051597)2.81343955
150glutamate receptor signaling pathway (GO:0007215)2.80932455
151oogenesis (GO:0048477)2.79798650
152regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.79466755
153amino acid import (GO:0043090)2.78015132
154regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.76741569
155single strand break repair (GO:0000012)2.76348738
156exploration behavior (GO:0035640)2.73199625
157centriole replication (GO:0007099)2.71216879
158amyloid precursor protein metabolic process (GO:0042982)2.69932429
159peptidyl-cysteine modification (GO:0018198)2.69606440
160leukocyte migration involved in inflammatory response (GO:0002523)2.66111064
161Leydig cell differentiation (GO:0033327)2.65240955
162activated T cell proliferation (GO:0050798)2.64930905
163mating behavior (GO:0007617)2.64806698
164histone H2B ubiquitination (GO:0033523)2.64132656
165axon development (GO:0061564)2.62861165
166gamma-aminobutyric acid signaling pathway (GO:0007214)2.62564188
167response to lipoprotein particle (GO:0055094)2.61135877
168dendrite morphogenesis (GO:0048813)2.59738672
169fatty-acyl-CoA metabolic process (GO:0035337)2.59320319
170response to catecholamine (GO:0071869)2.58624783
171response to monoamine (GO:0071867)2.58624783
172Golgi to plasma membrane protein transport (GO:0043001)2.58508788
173glial cell development (GO:0021782)2.58085871
174interleukin-6-mediated signaling pathway (GO:0070102)2.56686868
175L-serine transport (GO:0015825)2.55653466
176phosphatidylinositol 3-kinase signaling (GO:0014065)2.55585641
177negative regulation of JUN kinase activity (GO:0043508)2.54197400
178positive regulation of neurological system process (GO:0031646)2.53037885
179dendrite development (GO:0016358)2.51605320
180regulation of catecholamine metabolic process (GO:0042069)2.49856068
181regulation of dopamine metabolic process (GO:0042053)2.49856068
182negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47967040
183microtubule polymerization or depolymerization (GO:0031109)2.47708616
184acrosome reaction (GO:0007340)2.46467907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.65045848
2EZH2_22144423_ChIP-Seq_EOC_Human3.17982000
3TAF15_26573619_Chip-Seq_HEK293_Human2.71130126
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.51892427
5SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.51867023
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51824424
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43056686
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.36980396
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36781379
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.28943935
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11426032
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11426032
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08773733
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.02494520
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99538652
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99139530
17SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99011290
18OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94123423
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93961297
20VDR_22108803_ChIP-Seq_LS180_Human1.91808888
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91385262
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.87772814
23DROSHA_22980978_ChIP-Seq_HELA_Human1.86995759
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86659122
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84079398
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81955809
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81921129
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.76733849
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.75656993
30ER_23166858_ChIP-Seq_MCF-7_Human1.74572111
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71858572
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71588148
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67482904
34REST_21632747_ChIP-Seq_MESCs_Mouse1.66519545
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65356011
36AR_21572438_ChIP-Seq_LNCaP_Human1.61853912
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.61321615
38SMAD3_21741376_ChIP-Seq_ESCs_Human1.60870616
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.60299651
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57443228
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56546542
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53978109
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53887968
44CBP_20019798_ChIP-Seq_JUKART_Human1.53887968
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.52337455
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49104868
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46021037
48* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45541844
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44975567
50STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.41372534
51RNF2_27304074_Chip-Seq_NSC_Mouse1.41244602
52AR_25329375_ChIP-Seq_VCAP_Human1.38241321
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37855063
54* FUS_26573619_Chip-Seq_HEK293_Human1.37127891
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34052876
56* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33512750
57P300_19829295_ChIP-Seq_ESCs_Human1.31702203
58* SMAD4_21741376_ChIP-Seq_EPCs_Human1.28588417
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28472702
60* REST_18959480_ChIP-ChIP_MESCs_Mouse1.27233175
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24878683
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.24617764
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24005868
64* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.23420881
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23319207
66* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21335027
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20060932
68* STAT3_23295773_ChIP-Seq_U87_Human1.19016089
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18564541
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.18335697
71SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.18239000
72SMAD4_21799915_ChIP-Seq_A2780_Human1.17453386
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17144438
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16932719
75ZNF274_21170338_ChIP-Seq_K562_Hela1.15231481
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13667152
77SMAD4_21741376_ChIP-Seq_HESCs_Human1.13451214
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13256703
79TCF4_23295773_ChIP-Seq_U87_Human1.12811323
80AR_19668381_ChIP-Seq_PC3_Human1.12364742
81* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10738825
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.10218738
83JUN_21703547_ChIP-Seq_K562_Human1.09621077
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08435990
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.08317012
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.07586229
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07469867
88CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07158157
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07042917
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06387140
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.05717168
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.05448016
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03694131
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.03625563
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.00698108
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00318877
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00073075
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99097935
99P300_18555785_Chip-Seq_ESCs_Mouse0.98899462
100SOX9_26525672_Chip-Seq_HEART_Mouse0.98798649
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97702077
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96747806
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96594493
104RUNX2_22187159_ChIP-Seq_PCA_Human0.95495022
105SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95461555
106KDM2B_26808549_Chip-Seq_REH_Human0.95212810
107ETV1_20927104_ChIP-Seq_GIST48_Human0.94645794
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94536362
109* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94409230
110TCF4_22108803_ChIP-Seq_LS180_Human0.93426934
111* SOX2_21211035_ChIP-Seq_LN229_Gbm0.93378936
112TBL1_22424771_ChIP-Seq_293T_Human0.92567504
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90920596
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.90799006
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90669182
116* SMC4_20622854_ChIP-Seq_HELA_Human0.89547510
117SMAD4_21741376_ChIP-Seq_ESCs_Human0.89212681
118EOMES_21245162_ChIP-Seq_HESCs_Human0.88858786
119PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87948726
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87767533
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87767533
122ERA_21632823_ChIP-Seq_H3396_Human0.87337062
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87119745
124OCT1_27270436_Chip-Seq_PROSTATE_Human0.87044688
125AHR_22903824_ChIP-Seq_MCF-7_Human0.86544504
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.86443351
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86151158
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86082257
129NANOG_19829295_ChIP-Seq_ESCs_Human0.86003016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.82583697
2MP0003880_abnormal_central_pattern4.64005567
3MP0003646_muscle_fatigue4.47237196
4MP0002234_abnormal_pharynx_morphology3.77957638
5MP0004270_analgesia3.77658855
6MP0004859_abnormal_synaptic_plasticity3.32494900
7MP0003690_abnormal_glial_cell2.95951436
8MP0004885_abnormal_endolymph2.80806841
9MP0002272_abnormal_nervous_system2.67703324
10MP0005410_abnormal_fertilization2.67614845
11MP0004742_abnormal_vestibular_system2.59588868
12MP0001486_abnormal_startle_reflex2.58881319
13MP0002064_seizures2.57201204
14MP0005167_abnormal_blood-brain_barrier2.54283517
15MP0003329_amyloid_beta_deposits2.54035053
16MP0001529_abnormal_vocalization2.53876275
17MP0000778_abnormal_nervous_system2.49190505
18MP0009046_muscle_twitch2.44850386
19MP0003950_abnormal_plasma_membrane2.39953911
20MP0003635_abnormal_synaptic_transmissio2.38075919
21MP0001905_abnormal_dopamine_level2.36189669
22MP0003136_yellow_coat_color2.29516636
23MP0001485_abnormal_pinna_reflex2.26993501
24MP0003634_abnormal_glial_cell2.26725467
25MP0004233_abnormal_muscle_weight2.23537595
26MP0009745_abnormal_behavioral_response2.20930534
27MP0004142_abnormal_muscle_tone2.10770807
28MP0005409_darkened_coat_color2.01069918
29MP0005171_absent_coat_pigmentation1.99537991
30MP0005423_abnormal_somatic_nervous1.95415223
31MP0002734_abnormal_mechanical_nocicepti1.91306252
32MP0004858_abnormal_nervous_system1.84682556
33MP0000462_abnormal_digestive_system1.83473801
34MP0003632_abnormal_nervous_system1.80549617
35MP0002229_neurodegeneration1.78286191
36MP0002063_abnormal_learning/memory/cond1.77486199
37MP0001440_abnormal_grooming_behavior1.77421862
38MP0003718_maternal_effect1.77284104
39MP0010368_abnormal_lymphatic_system1.76703662
40MP0002572_abnormal_emotion/affect_behav1.72906463
41MP0005451_abnormal_body_composition1.69917474
42MP0003283_abnormal_digestive_organ1.69671767
43MP0000955_abnormal_spinal_cord1.61415995
44MP0009053_abnormal_anal_canal1.59674834
45MP0005377_hearing/vestibular/ear_phenot1.57574574
46MP0003878_abnormal_ear_physiology1.57574574
47MP0002882_abnormal_neuron_morphology1.56505118
48MP0004084_abnormal_cardiac_muscle1.47010563
49MP0005386_behavior/neurological_phenoty1.43935487
50MP0004924_abnormal_behavior1.43935487
51MP0010678_abnormal_skin_adnexa1.42137378
52MP0005623_abnormal_meninges_morphology1.42071095
53MP0002067_abnormal_sensory_capabilities1.40920560
54MP0005551_abnormal_eye_electrophysiolog1.39495923
55MP0002066_abnormal_motor_capabilities/c1.38610200
56MP0000383_abnormal_hair_follicle1.37485465
57MP0001929_abnormal_gametogenesis1.33765464
58MP0005670_abnormal_white_adipose1.31657480
59MP0004147_increased_porphyrin_level1.30832080
60MP0003879_abnormal_hair_cell1.28685487
61MP0002733_abnormal_thermal_nociception1.28586301
62MP0001963_abnormal_hearing_physiology1.28110596
63MP0008569_lethality_at_weaning1.25941327
64MP0002752_abnormal_somatic_nervous1.25911173
65MP0003631_nervous_system_phenotype1.23413869
66MP0008872_abnormal_physiological_respon1.22218918
67MP0003045_fibrosis1.21328134
68MP0001299_abnormal_eye_distance/1.20429767
69MP0000604_amyloidosis1.19142150
70MP0001970_abnormal_pain_threshold1.18933423
71MP0003938_abnormal_ear_development1.16884030
72MP0004134_abnormal_chest_morphology1.12423474
73MP0001968_abnormal_touch/_nociception1.11967885
74MP0003123_paternal_imprinting1.08506351
75MP0002152_abnormal_brain_morphology1.08073170
76MP0003698_abnormal_male_reproductive1.03223840
77MP0002161_abnormal_fertility/fecundity1.01214950
78MP0004381_abnormal_hair_follicle1.00668665
79MP0003937_abnormal_limbs/digits/tail_de0.99751398
80MP0002184_abnormal_innervation0.99057314
81MP0001501_abnormal_sleep_pattern0.98095566
82MP0004145_abnormal_muscle_electrophysio0.97120851
83MP0003633_abnormal_nervous_system0.96631350
84MP0002557_abnormal_social/conspecific_i0.95057401
85MP0000747_muscle_weakness0.94048811
86MP0002233_abnormal_nose_morphology0.94016368
87MP0003787_abnormal_imprinting0.92913337
88MP0004811_abnormal_neuron_physiology0.91716783
89MP0000026_abnormal_inner_ear0.89977350
90MP0002210_abnormal_sex_determination0.89967358
91MP0006276_abnormal_autonomic_nervous0.89701832
92MP0004133_heterotaxia0.89600202
93MP0002735_abnormal_chemical_nociception0.89412723
94MP0005195_abnormal_posterior_eye0.89164862
95MP0001661_extended_life_span0.89144979
96MP0001919_abnormal_reproductive_system0.89055160
97MP0006072_abnormal_retinal_apoptosis0.88764687
98MP0001346_abnormal_lacrimal_gland0.88516205
99MP0005499_abnormal_olfactory_system0.87802418
100MP0005394_taste/olfaction_phenotype0.87802418
101MP0002822_catalepsy0.83935907
102MP0004036_abnormal_muscle_relaxation0.81843428
103MP0003121_genomic_imprinting0.81394229
104MP0005646_abnormal_pituitary_gland0.81078908
105MP0001727_abnormal_embryo_implantation0.80755233
106MP0001177_atelectasis0.80181202
107MP0000762_abnormal_tongue_morphology0.79219893
108MP0002102_abnormal_ear_morphology0.79020991
109MP0005253_abnormal_eye_physiology0.78840016
110MP0003861_abnormal_nervous_system0.77995175
111MP0001984_abnormal_olfaction0.77208921
112MP0001664_abnormal_digestion0.75969675
113MP0000566_synostosis0.74491429
114MP0004043_abnormal_pH_regulation0.73796716
115MP0002736_abnormal_nociception_after0.72708744
116MP0002127_abnormal_cardiovascular_syste0.71551489
117MP0003119_abnormal_digestive_system0.71355930
118MP0000647_abnormal_sebaceous_gland0.70586637
119MP0008877_abnormal_DNA_methylation0.70491132
120MP0000467_abnormal_esophagus_morphology0.70187019
121MP0001502_abnormal_circadian_rhythm0.69594086
122MP0006082_CNS_inflammation0.69313180
123MP0001851_eye_inflammation0.68805898
124MP0005645_abnormal_hypothalamus_physiol0.67856289
125MP0008775_abnormal_heart_ventricle0.67709036
126MP0000631_abnormal_neuroendocrine_gland0.67453309
127MP0000653_abnormal_sex_gland0.67139595
128MP0004484_altered_response_of0.67099151
129MP0002069_abnormal_eating/drinking_beha0.66968100
130MP0001348_abnormal_lacrimal_gland0.66490400
131MP0000537_abnormal_urethra_morphology0.66311008
132MP0008260_abnormal_autophagy0.65526093
133MP0003137_abnormal_impulse_conducting0.64182885
134MP0002295_abnormal_pulmonary_circulatio0.60272233
135MP0004185_abnormal_adipocyte_glucose0.58549789
136MP0003122_maternal_imprinting0.57990889

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.25694836
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.25694836
3Neurofibrillary tangles (HP:0002185)5.96393004
4Sensory axonal neuropathy (HP:0003390)5.94638009
5Lip pit (HP:0100267)5.14150864
6Abnormality of the corticospinal tract (HP:0002492)4.86220750
7Autoimmune thrombocytopenia (HP:0001973)4.73485175
8Parakeratosis (HP:0001036)4.72395709
9Sparse lateral eyebrow (HP:0005338)4.52159793
10Anal stenosis (HP:0002025)4.43749638
11Cerebral inclusion bodies (HP:0100314)4.39245244
12Peripheral hypomyelination (HP:0007182)4.29489364
13Depressed nasal tip (HP:0000437)4.21212254
14Intestinal fistula (HP:0100819)4.17356648
15Akinesia (HP:0002304)3.96869986
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.89640385
17Abnormality of the fingertips (HP:0001211)3.81728827
18Supranuclear gaze palsy (HP:0000605)3.80217840
19Spastic gait (HP:0002064)3.79964566
20Absent/shortened dynein arms (HP:0200106)3.63995681
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.63995681
22Febrile seizures (HP:0002373)3.55514605
23Short 5th finger (HP:0009237)3.44126417
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.41189272
25Intention tremor (HP:0002080)3.39178898
26Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.30252042
27Ureteral stenosis (HP:0000071)3.30203955
28Dysmetria (HP:0001310)3.27462616
29Myokymia (HP:0002411)3.24052025
30Cerebral hypomyelination (HP:0006808)3.23342416
31Onion bulb formation (HP:0003383)3.14640172
32Termporal pattern (HP:0011008)3.11772045
33Insidious onset (HP:0003587)3.11772045
34Severe visual impairment (HP:0001141)3.10044087
35Progressive cerebellar ataxia (HP:0002073)3.09807880
36Alacrima (HP:0000522)3.07630599
37Postural instability (HP:0002172)3.04845660
38Atonic seizures (HP:0010819)3.01060019
39Ureteral obstruction (HP:0006000)2.98731778
40Absence seizures (HP:0002121)2.98459998
41Ectopic kidney (HP:0000086)2.98110639
42Periauricular skin pits (HP:0100277)2.97440191
43Preauricular pit (HP:0004467)2.97440191
44Chronic hepatic failure (HP:0100626)2.96301739
45Resting tremor (HP:0002322)2.84472148
46Dialeptic seizures (HP:0011146)2.79079801
47Retinal dysplasia (HP:0007973)2.70234038
48Abnormal drinking behavior (HP:0030082)2.69983914
49Polydipsia (HP:0001959)2.69983914
50Ankle clonus (HP:0011448)2.67670105
51Abnormality of glycolysis (HP:0004366)2.67252007
52Increased serum pyruvate (HP:0003542)2.67252007
53Scanning speech (HP:0002168)2.66780225
54Abnormal auditory evoked potentials (HP:0006958)2.66772700
55Abnormal respiratory motile cilium physiology (HP:0012261)2.60678263
56Congenital ichthyosiform erythroderma (HP:0007431)2.59881257
57Spastic paraparesis (HP:0002313)2.57939972
58Hypoplastic pelvis (HP:0008839)2.55538905
59Amblyopia (HP:0000646)2.54285145
60Abnormal ciliary motility (HP:0012262)2.52372678
61Popliteal pterygium (HP:0009756)2.52240131
62Partial agenesis of the corpus callosum (HP:0001338)2.49470077
63Abnormality of cochlea (HP:0000375)2.48371261
64Lower limb hyperreflexia (HP:0002395)2.47057729
65Thickened helices (HP:0000391)2.46206850
66Absent septum pellucidum (HP:0001331)2.46015298
67Leukodystrophy (HP:0002415)2.45915017
68Limb dystonia (HP:0002451)2.42485953
69Slow saccadic eye movements (HP:0000514)2.42292056
70Anteriorly placed anus (HP:0001545)2.41790773
71Decreased lacrimation (HP:0000633)2.41285038
72Increased circulating renin level (HP:0000848)2.35095690
73Abnormal respiratory epithelium morphology (HP:0012253)2.31530315
74Abnormal respiratory motile cilium morphology (HP:0005938)2.31530315
75Focal motor seizures (HP:0011153)2.30958439
76Coronal craniosynostosis (HP:0004440)2.30642461
77Autoamputation (HP:0001218)2.30131641
78Premature skin wrinkling (HP:0100678)2.27272302
79Tubulointerstitial nephritis (HP:0001970)2.26287159
80Lower limb muscle weakness (HP:0007340)2.25249937
81Abnormal eating behavior (HP:0100738)2.24695289
82Facial cleft (HP:0002006)2.23459288
83Confusion (HP:0001289)2.23371693
84Abnormality of the periventricular white matter (HP:0002518)2.22162891
85Clumsiness (HP:0002312)2.20253132
86Generalized aminoaciduria (HP:0002909)2.15116461
87Anomalous pulmonary venous return (HP:0010772)2.14456587
88Aplasia involving bones of the upper limbs (HP:0009823)2.14444050
89Aplasia of the phalanges of the hand (HP:0009802)2.14444050
90Aplasia involving bones of the extremities (HP:0009825)2.14444050
91Split foot (HP:0001839)2.13992913
92Chronic bronchitis (HP:0004469)2.13212878
93Fetal akinesia sequence (HP:0001989)2.12639302
94Absent eyebrow (HP:0002223)2.11995419
95Cerebral hemorrhage (HP:0001342)2.10454396
96Facial shape deformation (HP:0011334)2.10194247
97Potter facies (HP:0002009)2.10194247
98Epileptic encephalopathy (HP:0200134)2.09607027
99Preaxial foot polydactyly (HP:0001841)2.09425286
100Stridor (HP:0010307)2.09251956
101Abnormality of the septum pellucidum (HP:0007375)2.08711518
102Generalized myoclonic seizures (HP:0002123)2.07482389
103Gaze-evoked nystagmus (HP:0000640)2.04033283
104Pheochromocytoma (HP:0002666)2.03343732
105Morphological abnormality of the inner ear (HP:0011390)2.03270838
106Cupped ear (HP:0000378)2.02786524
107Diminished movement (HP:0002374)2.02701107
108Polyuria (HP:0000103)2.01463299
109Relative macrocephaly (HP:0004482)2.01164114
110Subcapsular cataract (HP:0000523)2.00011846
111Hyperventilation (HP:0002883)1.99656464
112Abnormal urine output (HP:0012590)1.98940897
113Hypomagnesemia (HP:0002917)1.97964934
114Adrenal hypoplasia (HP:0000835)1.97689531
115Synostosis involving the elbow (HP:0003938)1.96354881
116Humeroradial synostosis (HP:0003041)1.96354881
117Megalencephaly (HP:0001355)1.96219144
118Skin pits (HP:0100276)1.95925991
119Posterior subcapsular cataract (HP:0007787)1.95874814
120Abnormality of the renal cortex (HP:0011035)1.94644679
121Bowel incontinence (HP:0002607)1.94631584
122Rhinitis (HP:0012384)1.94455967
123Mask-like facies (HP:0000298)1.93412216
124Tubulointerstitial abnormality (HP:0001969)1.93403114
125Long palpebral fissure (HP:0000637)1.93320386
126Infantile muscular hypotonia (HP:0008947)1.93266526
127Status epilepticus (HP:0002133)1.93120309
128Pancreatic cysts (HP:0001737)1.91555280
129Steppage gait (HP:0003376)1.90487488
130Clonus (HP:0002169)1.89427734
131Septo-optic dysplasia (HP:0100842)1.89380219
132CNS hypomyelination (HP:0003429)1.89072521
133Small epiphyses (HP:0010585)1.86544370
134Focal seizures (HP:0007359)1.86539744
135Vaginal atresia (HP:0000148)1.85966639
136Action tremor (HP:0002345)1.85177680
137Morphological abnormality of the pyramidal tract (HP:0002062)1.84723807
138Increased CSF protein (HP:0002922)1.83390910
139Neuroendocrine neoplasm (HP:0100634)1.83218608
140Abnormality of the phalanges of the 2nd finger (HP:0009541)1.82144641
141Broad-based gait (HP:0002136)1.81750937
142Annular pancreas (HP:0001734)1.80212791
143Abnormality of the pulmonary veins (HP:0011718)1.80170737
144Genital tract atresia (HP:0001827)1.78158582
145Abnormal large intestine physiology (HP:0012700)1.77075310
146Type II lissencephaly (HP:0007260)1.76399448
147Widely spaced teeth (HP:0000687)1.76232474
148Spastic tetraparesis (HP:0001285)1.76111589
149Decreased motor nerve conduction velocity (HP:0003431)1.75654715
150Esophageal atresia (HP:0002032)1.75587498
151Urinary urgency (HP:0000012)1.73780789
152Obstructive sleep apnea (HP:0002870)1.73687159
153Impaired vibration sensation in the lower limbs (HP:0002166)1.73445032
154Absent eyelashes (HP:0000561)1.72492995
155Sleep apnea (HP:0010535)1.72435392
156Infertility (HP:0000789)1.72271495
157Progressive inability to walk (HP:0002505)1.71525772
158Bradykinesia (HP:0002067)1.71481128
159Generalized tonic-clonic seizures (HP:0002069)1.71399217
160Hammertoe (HP:0001765)1.71296059
161Erythroderma (HP:0001019)1.69694384
162Self-mutilation (HP:0000742)1.69014253
163Dysdiadochokinesis (HP:0002075)1.68437234
164Polyphagia (HP:0002591)1.68180136
165Abnormality of the aortic arch (HP:0012303)1.68090888
166Hypoplastic labia majora (HP:0000059)1.67494985
167Tubular atrophy (HP:0000092)1.64396307
168Abnormality of renal excretion (HP:0011036)1.63244397
169Non-midline cleft lip (HP:0100335)1.63004701
170Abnormality of binocular vision (HP:0011514)1.62701866
171Diplopia (HP:0000651)1.62701866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.35023625
2STK245.57621135
3OXSR14.42743216
4PINK13.73894907
5CCNB13.62217439
6TNIK3.57516203
7CDK192.92356396
8PLK42.91746147
9BCR2.87728117
10WNK42.85821415
11ICK2.82638021
12EPHB12.76692687
13PNCK2.38704607
14MET2.03186786
15WNK12.02123748
16EPHA41.97278496
17PKN11.96641573
18PRPF4B1.95738421
19PLK21.95410746
20EEF2K1.94345515
21PBK1.87786322
22CAMK11.86796152
23UHMK11.81453847
24PAK61.75024869
25MAP3K31.72900837
26CSNK1G31.71602391
27DAPK21.70538978
28LIMK11.68577175
29FGFR21.68290179
30NTRK11.64977532
31NEK61.61857611
32CSNK1A1L1.55755437
33CAMK41.54827635
34MARK11.52692359
35ILK1.52415155
36ZAK1.45403963
37TYRO31.39720794
38INSRR1.39111284
39JAK31.37984859
40CSNK1G11.36653497
41CSNK1G21.34785166
42FGR1.33917427
43ROCK21.31631016
44CLK11.26972184
45CAMK2B1.25964561
46CASK1.22406989
47ARAF1.17399795
48MAPKAPK51.08842156
49PAK31.07280972
50CDK141.04672229
51CAMK2D1.03284027
52MAP4K21.00512397
53CDC71.00207757
54TESK20.99125858
55CDK50.98606592
56MAP3K90.97224610
57MARK20.96102097
58WNK30.95605164
59CAMK1D0.90330812
60CDK150.89955150
61CHEK20.89322860
62CAMKK10.89156455
63BRD40.88098318
64CDK180.85660110
65MAPKAPK30.84346471
66STK380.82124087
67CDK11A0.81285118
68DYRK20.80634763
69CAMK2A0.80163417
70MST40.79972214
71PRKCQ0.79092751
72IRAK20.77993090
73TESK10.77737520
74CAMK2G0.75361798
75NTRK30.73257481
76NTRK20.73197285
77CAMKK20.72872092
78SGK4940.69897407
79SGK2230.69897407
80ERBB40.69308366
81SGK20.65528546
82RPS6KA60.64281763
83MAP3K40.63682595
84FES0.63038444
85RPS6KC10.61343930
86RPS6KL10.61343930
87IRAK10.61266507
88FYN0.60810233
89KSR20.60769997
90STK110.60406053
91MAPK130.60124694
92MAPK150.59357799
93PHKG20.57795667
94PHKG10.57795667
95MINK10.57124915
96PRKCZ0.56315931
97MAP3K130.51628842
98PDPK10.51322935
99EPHB20.50797571
100PTK2B0.49634184
101SGK10.48834946
102RPS6KA20.48415373
103CSNK1D0.48387065
104PRKCE0.47508736
105BMPR1B0.46712021
106MELK0.44830202
107CAMK1G0.41128707
108SIK20.39660697
109LATS20.39366105
110PRKG10.38523731
111PRKCH0.38191391
112PRKD10.36936105
113PRKD30.36272404
114MAP2K70.35783320
115PRKCG0.34409005
116ROCK10.34279422
117PAK10.33118286
118MAP3K20.32723156
119STK38L0.31978684
120PRKACB0.31749021
121DDR20.31366304
122SRPK10.31355612
123MAPK120.30781198
124DYRK1A0.30742242
125CSNK1A10.30685897
126PDK10.29288302
127KSR10.28426340
128PDGFRB0.28005903
129TTK0.27977605
130MAPK70.27914378
131INSR0.26717769
132ADRBK20.26568965
133MAPK100.25647463
134MUSK0.25457164
135PRKCA0.24624019
136CDK20.24172779
137GSK3B0.24049587
138CSNK1E0.23377630
139SGK30.22656682
140PRKACA0.22518097
141ERBB30.22157157
142RPS6KA30.21839376
143GRK50.21412096

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.14740341
2Steroid biosynthesis_Homo sapiens_hsa001004.22949280
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.66142426
4Fatty acid elongation_Homo sapiens_hsa000623.55205440
5Arginine biosynthesis_Homo sapiens_hsa002203.31836340
6Ether lipid metabolism_Homo sapiens_hsa005652.97280677
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48483199
8Axon guidance_Homo sapiens_hsa043602.43056980
9Oxidative phosphorylation_Homo sapiens_hsa001902.00714648
10Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.80265094
11GABAergic synapse_Homo sapiens_hsa047271.77678997
12Glutamatergic synapse_Homo sapiens_hsa047241.75851091
13Sphingolipid metabolism_Homo sapiens_hsa006001.71419040
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70840707
15Serotonergic synapse_Homo sapiens_hsa047261.68808969
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.62301716
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61383109
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61007147
19Nicotine addiction_Homo sapiens_hsa050331.59337062
20Butanoate metabolism_Homo sapiens_hsa006501.58314846
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54813655
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54131448
23Morphine addiction_Homo sapiens_hsa050321.51720881
24Collecting duct acid secretion_Homo sapiens_hsa049661.45266560
25Sulfur metabolism_Homo sapiens_hsa009201.38517624
26Renal cell carcinoma_Homo sapiens_hsa052111.35820041
27Alzheimers disease_Homo sapiens_hsa050101.35073124
28Parkinsons disease_Homo sapiens_hsa050121.34638469
29Synaptic vesicle cycle_Homo sapiens_hsa047211.33665295
30Protein export_Homo sapiens_hsa030601.29840241
31Linoleic acid metabolism_Homo sapiens_hsa005911.26246529
32Long-term depression_Homo sapiens_hsa047301.25255883
33Vibrio cholerae infection_Homo sapiens_hsa051101.19593061
34AMPK signaling pathway_Homo sapiens_hsa041521.17112518
35Circadian entrainment_Homo sapiens_hsa047131.15469680
36Vitamin B6 metabolism_Homo sapiens_hsa007501.14638846
37Oocyte meiosis_Homo sapiens_hsa041141.13933087
38Cardiac muscle contraction_Homo sapiens_hsa042601.12905330
39Dopaminergic synapse_Homo sapiens_hsa047281.10614248
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10235071
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05600997
42Tight junction_Homo sapiens_hsa045301.05385374
43Lysine degradation_Homo sapiens_hsa003101.02993935
44mRNA surveillance pathway_Homo sapiens_hsa030151.00793356
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.97136790
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96700190
47Cholinergic synapse_Homo sapiens_hsa047250.96128151
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93532541
49beta-Alanine metabolism_Homo sapiens_hsa004100.92749747
50Salivary secretion_Homo sapiens_hsa049700.92340968
51ErbB signaling pathway_Homo sapiens_hsa040120.91658886
52Dorso-ventral axis formation_Homo sapiens_hsa043200.91129561
53Nitrogen metabolism_Homo sapiens_hsa009100.90837448
54Cocaine addiction_Homo sapiens_hsa050300.90147408
55Ras signaling pathway_Homo sapiens_hsa040140.89147736
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88258543
57Fatty acid biosynthesis_Homo sapiens_hsa000610.87590200
58Huntingtons disease_Homo sapiens_hsa050160.87523332
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.87207953
60Long-term potentiation_Homo sapiens_hsa047200.84048468
61* Endocytosis_Homo sapiens_hsa041440.83218374
62Amphetamine addiction_Homo sapiens_hsa050310.82900325
63Type II diabetes mellitus_Homo sapiens_hsa049300.82669878
64Phototransduction_Homo sapiens_hsa047440.82351619
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.79136121
66Rheumatoid arthritis_Homo sapiens_hsa053230.77670703
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74525157
68Estrogen signaling pathway_Homo sapiens_hsa049150.73264839
69Arginine and proline metabolism_Homo sapiens_hsa003300.72797203
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71479775
71Gastric acid secretion_Homo sapiens_hsa049710.71466143
72Hedgehog signaling pathway_Homo sapiens_hsa043400.70205683
73Ovarian steroidogenesis_Homo sapiens_hsa049130.68397273
74Hippo signaling pathway_Homo sapiens_hsa043900.68127316
75Renin secretion_Homo sapiens_hsa049240.67824534
76Glioma_Homo sapiens_hsa052140.67490374
77Gap junction_Homo sapiens_hsa045400.67434210
78Selenocompound metabolism_Homo sapiens_hsa004500.66688263
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66381777
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.66071875
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65867031
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64921631
83Histidine metabolism_Homo sapiens_hsa003400.62635342
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62377495
85Taste transduction_Homo sapiens_hsa047420.61752646
86Oxytocin signaling pathway_Homo sapiens_hsa049210.61478658
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61412096
88Olfactory transduction_Homo sapiens_hsa047400.61340954
89Fatty acid metabolism_Homo sapiens_hsa012120.60880755
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60663445
91Choline metabolism in cancer_Homo sapiens_hsa052310.60610124
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59143533
93cAMP signaling pathway_Homo sapiens_hsa040240.57758323
94Inositol phosphate metabolism_Homo sapiens_hsa005620.56504801
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56116041
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55614741
97Glutathione metabolism_Homo sapiens_hsa004800.55327700
98Autoimmune thyroid disease_Homo sapiens_hsa053200.55186565
99RNA transport_Homo sapiens_hsa030130.54926401
100Bile secretion_Homo sapiens_hsa049760.54263284
101Pancreatic secretion_Homo sapiens_hsa049720.53319041
102Calcium signaling pathway_Homo sapiens_hsa040200.52289760
103Alcoholism_Homo sapiens_hsa050340.50292774
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.49514780
105Rap1 signaling pathway_Homo sapiens_hsa040150.49354161
106Arachidonic acid metabolism_Homo sapiens_hsa005900.48254094
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48035202
108MAPK signaling pathway_Homo sapiens_hsa040100.46978826
109Phagosome_Homo sapiens_hsa041450.45517058
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44613525
111Wnt signaling pathway_Homo sapiens_hsa043100.42642593
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41508141
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.40769193
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39917730
115Basal transcription factors_Homo sapiens_hsa030220.37369850
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.37344588
117ECM-receptor interaction_Homo sapiens_hsa045120.37024480
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36982905
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36816751
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35496710
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35358827
122Thyroid hormone synthesis_Homo sapiens_hsa049180.34008781
123Insulin secretion_Homo sapiens_hsa049110.33767889
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33681212
125Dilated cardiomyopathy_Homo sapiens_hsa054140.33623815
126Melanogenesis_Homo sapiens_hsa049160.33244529
127Insulin signaling pathway_Homo sapiens_hsa049100.32878636
128Propanoate metabolism_Homo sapiens_hsa006400.32624751
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.31688625
130TGF-beta signaling pathway_Homo sapiens_hsa043500.31142449
131Malaria_Homo sapiens_hsa051440.29593210
132GnRH signaling pathway_Homo sapiens_hsa049120.28982332
133Regulation of autophagy_Homo sapiens_hsa041400.28218363
134ABC transporters_Homo sapiens_hsa020100.25514472
135Glycerolipid metabolism_Homo sapiens_hsa005610.25299335
136Phenylalanine metabolism_Homo sapiens_hsa003600.23992839
137Adherens junction_Homo sapiens_hsa045200.23864199
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23401271
139Glucagon signaling pathway_Homo sapiens_hsa049220.22325792

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