SH3GLB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)5.39291717
2plasma membrane fusion (GO:0045026)4.58060115
3cilium or flagellum-dependent cell motility (GO:0001539)4.45087478
4acrosome assembly (GO:0001675)4.28168646
5sperm motility (GO:0030317)4.25211238
6cell wall macromolecule catabolic process (GO:0016998)4.18803003
7cell wall macromolecule metabolic process (GO:0044036)4.18803003
8multicellular organism reproduction (GO:0032504)4.06005186
9actin-myosin filament sliding (GO:0033275)3.75334230
10muscle filament sliding (GO:0030049)3.75334230
11reproduction (GO:0000003)3.66264599
12acrosome reaction (GO:0007340)3.62805580
13low-density lipoprotein particle clearance (GO:0034383)3.61503949
14plasma membrane repair (GO:0001778)3.59846844
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.54076034
16regulation of sequestering of triglyceride (GO:0010889)3.45930840
17sperm-egg recognition (GO:0035036)3.38271916
18protein localization to endosome (GO:0036010)3.32074873
19positive regulation of myotube differentiation (GO:0010831)3.20065453
20actin-mediated cell contraction (GO:0070252)3.18447134
21regulation of skeletal muscle contraction (GO:0014819)3.12824995
22sperm capacitation (GO:0048240)3.12450262
23positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.10641867
24cell-cell recognition (GO:0009988)3.10631414
25carnitine transmembrane transport (GO:1902603)3.10385886
26sarcomere organization (GO:0045214)3.09547452
27detection of molecule of bacterial origin (GO:0032490)3.09408887
28cell adhesion mediated by integrin (GO:0033627)3.05546780
29retina vasculature morphogenesis in camera-type eye (GO:0061299)3.04222228
30membrane raft organization (GO:0031579)2.96663300
31regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.96274914
32growth hormone receptor signaling pathway (GO:0060396)2.94193572
33carnitine transport (GO:0015879)2.91731934
34amino-acid betaine transport (GO:0015838)2.91731934
35epithelial cilium movement (GO:0003351)2.91399910
36carnitine shuttle (GO:0006853)2.89092655
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.87794817
38positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85422966
39fatty acid transmembrane transport (GO:1902001)2.84301955
40positive regulation of receptor recycling (GO:0001921)2.81535367
41creatine metabolic process (GO:0006600)2.80086833
42axonemal dynein complex assembly (GO:0070286)2.77367333
43binding of sperm to zona pellucida (GO:0007339)2.75690664
44response to lipoprotein particle (GO:0055094)2.75673729
45negative regulation of inclusion body assembly (GO:0090084)2.71686974
46motile cilium assembly (GO:0044458)2.70299832
47cellular response to epinephrine stimulus (GO:0071872)2.69082720
48actin filament-based movement (GO:0030048)2.68650073
49regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.63858313
50negative regulation of potassium ion transmembrane transport (GO:1901380)2.62848148
51regulation of p38MAPK cascade (GO:1900744)2.62162223
52regulation of relaxation of muscle (GO:1901077)2.62151636
53barbed-end actin filament capping (GO:0051016)2.61094494
54vascular endothelial growth factor signaling pathway (GO:0038084)2.60436769
55cellular response to growth hormone stimulus (GO:0071378)2.58633904
56positive regulation of macrophage cytokine production (GO:0060907)2.58381336
57cortical actin cytoskeleton organization (GO:0030866)2.58314439
58cellular extravasation (GO:0045123)2.57382213
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.55445169
60positive regulation by organism of defense response of other organism involved in symbiotic interact2.55445169
61modulation by symbiont of host immune response (GO:0052553)2.55445169
62positive regulation by symbiont of host defense response (GO:0052509)2.55445169
63modulation by symbiont of host defense response (GO:0052031)2.55445169
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.55445169
65spermatid development (GO:0007286)2.55031153
66regulation of cholesterol storage (GO:0010885)2.54651073
67glomerular filtration (GO:0003094)2.53652194
68positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.52317641
69sarcoplasmic reticulum calcium ion transport (GO:0070296)2.52064902
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.51692766
71negative regulation of cell killing (GO:0031342)2.51692766
72skeletal muscle fiber development (GO:0048741)2.51293536
73stress fiber assembly (GO:0043149)2.51089487
74skeletal muscle contraction (GO:0003009)2.50418838
75germinal center formation (GO:0002467)2.48787991
76myelin maintenance (GO:0043217)2.48099330
77cellular response to arsenic-containing substance (GO:0071243)2.47502284
78renal filtration (GO:0097205)2.46826454
79import into cell (GO:0098657)2.45928148
80positive regulation of p38MAPK cascade (GO:1900745)2.45339560
81response to inactivity (GO:0014854)2.45182589
82muscle cell fate commitment (GO:0042693)2.45054192
83semaphorin-plexin signaling pathway (GO:0071526)2.43518652
84response to peptidoglycan (GO:0032494)2.43286809
85myofibril assembly (GO:0030239)2.38904143
86intracellular lipid transport (GO:0032365)2.38038564
87apoptotic cell clearance (GO:0043277)2.37789252
88striated muscle atrophy (GO:0014891)2.37365370
89fibril organization (GO:0097435)2.37077882
90detection of external biotic stimulus (GO:0098581)2.36277742
91macrophage activation involved in immune response (GO:0002281)2.36099660
92neutrophil activation involved in immune response (GO:0002283)2.35795757
93response to epinephrine (GO:0071871)2.34463412
94ruffle organization (GO:0031529)2.34396287
95single fertilization (GO:0007338)2.33986119
96nerve growth factor signaling pathway (GO:0038180)2.31792800
97positive regulation of gamma-delta T cell activation (GO:0046645)2.31431161
98regulation of macrophage cytokine production (GO:0010935)2.31263422
99detection of other organism (GO:0098543)2.30063310
100syncytium formation by plasma membrane fusion (GO:0000768)2.30055604
101interleukin-6-mediated signaling pathway (GO:0070102)2.29641301
102myoblast fusion (GO:0007520)2.29102239
103negative regulation of fatty acid transport (GO:2000192)2.29046972
104syncytium formation (GO:0006949)2.28985279
105hypotonic response (GO:0006971)2.28870077
106cardiac myofibril assembly (GO:0055003)2.28304250
107membrane protein ectodomain proteolysis (GO:0006509)2.28141762
108collagen fibril organization (GO:0030199)2.27741986
109sexual reproduction (GO:0019953)2.27172546
110positive regulation of histone deacetylation (GO:0031065)2.26834972
111negative regulation of interleukin-12 production (GO:0032695)2.25470008
112cortical cytoskeleton organization (GO:0030865)2.25167056
113localization within membrane (GO:0051668)2.24385247
114cilium movement (GO:0003341)2.24134369
115macroautophagy (GO:0016236)2.22955913
116extracellular fibril organization (GO:0043206)2.22169595
117skin morphogenesis (GO:0043589)2.21025337
118protein heterotrimerization (GO:0070208)2.20981664
119regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.19297385
120brown fat cell differentiation (GO:0050873)2.18798484
121Rap protein signal transduction (GO:0032486)2.18157173
122cellular response to osmotic stress (GO:0071470)2.17479625
123platelet-derived growth factor receptor signaling pathway (GO:0048008)2.17009546
124cytoplasmic mRNA processing body assembly (GO:0033962)2.16988774
125negative regulation of smooth muscle cell migration (GO:0014912)2.16851267
126regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.16844300
127endothelium development (GO:0003158)2.16561085
128negative regulation of protein localization to plasma membrane (GO:1903077)2.15987013
129heart trabecula formation (GO:0060347)2.15809200
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.15048151
131regulation of receptor recycling (GO:0001919)2.14608220
132regulation of interferon-beta biosynthetic process (GO:0045357)2.14597285
133basement membrane organization (GO:0071711)2.14435460
134blood vessel maturation (GO:0001955)2.13174490
135endodermal cell differentiation (GO:0035987)2.12949863
136positive regulation of monocyte chemotaxis (GO:0090026)2.11771473
137hippo signaling (GO:0035329)2.11743865
138endothelial cell morphogenesis (GO:0001886)2.11152460
139regulation of necroptotic process (GO:0060544)2.10926755
140response to muramyl dipeptide (GO:0032495)2.10743249
141positive regulation of cellular amide metabolic process (GO:0034250)2.10474557
142response to host (GO:0075136)2.10249953
143response to host defenses (GO:0052200)2.10249953
144response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.10249953
145actomyosin structure organization (GO:0031032)2.09540363
146response to host immune response (GO:0052572)2.09331209
147response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.09331209
148negative regulation of erythrocyte differentiation (GO:0045647)2.08051863
149macrophage activation (GO:0042116)2.07609457
150negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.07454382
151negative regulation of anoikis (GO:2000811)2.06004439
152negative regulation of lipid storage (GO:0010888)2.05650785
153antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.03786170
154positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.02371696
155wound healing, spreading of epidermal cells (GO:0035313)1.99917088
156regulation of nitric-oxide synthase biosynthetic process (GO:0051769)1.99356506
157regulation of chemokine-mediated signaling pathway (GO:0070099)1.99206730
158response to laminar fluid shear stress (GO:0034616)1.98969535
159lipopolysaccharide-mediated signaling pathway (GO:0031663)1.98876221
160positive regulation of membrane protein ectodomain proteolysis (GO:0051044)1.98790999
161regulation of transforming growth factor beta2 production (GO:0032909)1.94357074
162venous blood vessel morphogenesis (GO:0048845)1.93729645
163detection of biotic stimulus (GO:0009595)1.93549064
164regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO1.93473022
165cellular response to thyroid hormone stimulus (GO:0097067)1.93222064
166negative regulation of protein localization to cell surface (GO:2000009)1.92218601
167regulation of platelet aggregation (GO:0090330)1.91845910
168negative regulation of macrophage derived foam cell differentiation (GO:0010745)1.91077080
169regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.89416066
170substrate-dependent cell migration (GO:0006929)1.88467841
171regulation of platelet activation (GO:0010543)1.88405439
172negative regulation of interleukin-17 production (GO:0032700)1.88125489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human2.98886046
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.80466791
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.65345924
4CDX2_19796622_ChIP-Seq_MESCs_Mouse2.33229372
5EP300_21415370_ChIP-Seq_HL-1_Mouse2.16767563
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05256431
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98895727
8RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95193882
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95167655
10CJUN_26792858_Chip-Seq_BT549_Human1.89235810
11GATA2_21666600_ChIP-Seq_HMVEC_Human1.87982810
12TP63_17297297_ChIP-ChIP_HaCaT_Human1.83931464
13CLOCK_20551151_ChIP-Seq_293T_Human1.83166677
14* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78011141
15TBX20_22080862_ChIP-Seq_HEART_Mouse1.74411655
16TBX20_22328084_ChIP-Seq_HEART_Mouse1.74411655
17VDR_24787735_ChIP-Seq_THP-1_Human1.71875315
18* IRF8_27001747_Chip-Seq_BMDM_Mouse1.71638918
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65062864
20CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.63371869
21PPAR_26484153_Chip-Seq_NCI-H1993_Human1.61348402
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.61255942
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60413969
24* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59499590
25* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59044335
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57287807
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57250190
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55538581
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55286510
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55185061
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53625665
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52502269
33* FOXO3_23340844_ChIP-Seq_DLD1_Human1.51812393
34PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.49997301
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47281660
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44257479
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44257479
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.41186431
39JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38383811
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36840164
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36712315
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36143444
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.34518904
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.33074393
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32539555
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32501010
47NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31448824
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.30065472
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28304638
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20542834
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17522820
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17393305
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15365339
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15283579
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15283579
56JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14455278
57* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14307325
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14270967
59RUNX_20019798_ChIP-Seq_JUKART_Human1.14144984
60* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12065441
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11189666
62ZNF274_21170338_ChIP-Seq_K562_Hela1.10832710
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10148945
64BRD4_25478319_ChIP-Seq_HGPS_Human1.08060363
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07403280
66GBX2_23144817_ChIP-Seq_PC3_Human1.06605671
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05750996
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05605770
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04430702
70MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04359825
71* TCF4_18268006_ChIP-ChIP_LS174T_Human1.03415359
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01730209
73GATA1_19941826_ChIP-Seq_K562_Human1.01041342
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.00670936
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00563413
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00285907
77TP53_18474530_ChIP-ChIP_U2OS_Human1.00127185
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99838611
79TP53_16413492_ChIP-PET_HCT116_Human0.99326050
80TP63_23658742_ChIP-Seq_EP156T_Human0.98471425
81SOX2_20726797_ChIP-Seq_SW620_Human0.97452512
82ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96902648
83SMAD_19615063_ChIP-ChIP_OVARY_Human0.95919314
84ER_23166858_ChIP-Seq_MCF-7_Human0.95864729
85ESR2_21235772_ChIP-Seq_MCF-7_Human0.95154030
86PIAS1_25552417_ChIP-Seq_VCAP_Human0.93990024
87BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93657161
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93477761
89GATA2_19941826_ChIP-Seq_K562_Human0.93220257
90* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93118537
91* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93013389
92* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92931642
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92014538
94PU_27001747_Chip-Seq_BMDM_Mouse0.90133674
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89732691
96CBP_20019798_ChIP-Seq_JUKART_Human0.89525273
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89525273
98* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89426556
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89095956
100SMAD4_21799915_ChIP-Seq_A2780_Human0.88900792
101HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88646702
102SPI1_23127762_ChIP-Seq_K562_Human0.88398255
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87794792
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87747613
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86355868
106* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86296215
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86191897
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.85760655
109FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85650925
110LXR_22158963_ChIP-Seq_LIVER_Mouse0.85551672
111EZH2_27294783_Chip-Seq_NPCs_Mouse0.85106609
112GATA1_22025678_ChIP-Seq_K562_Human0.84648695
113AHR_22903824_ChIP-Seq_MCF-7_Human0.84613465
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84409502
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.83497959
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82926489
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82782420
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82488712
119FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82437499
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82174586
121* UBF1/2_26484160_Chip-Seq_HMECs_Human0.81934054
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81454429
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81387223
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.81237625
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.81130847
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80398153
127CDX2_22108803_ChIP-Seq_LS180_Human0.80300926
128GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80098450
129* KDM2B_26808549_Chip-Seq_DND41_Human0.78912114
130FOXA2_19822575_ChIP-Seq_HepG2_Human0.78443490
131KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78384027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.19276555
2MP0005410_abnormal_fertilization3.81624508
3MP0004130_abnormal_muscle_cell2.83575789
4MP0003950_abnormal_plasma_membrane2.70563436
5MP0000749_muscle_degeneration2.65784684
6MP0000733_abnormal_muscle_development2.62482465
7MP0000751_myopathy2.58724230
8MP0005275_abnormal_skin_tensile2.52255294
9MP0004185_abnormal_adipocyte_glucose2.45098113
10MP0005623_abnormal_meninges_morphology2.40634354
11MP0005666_abnormal_adipose_tissue2.39273533
12MP0005670_abnormal_white_adipose2.35804917
13MP0000750_abnormal_muscle_regeneration2.23844954
14MP0004087_abnormal_muscle_fiber2.20163614
15MP0003705_abnormal_hypodermis_morpholog2.14641925
16MP0004272_abnormal_basement_membrane2.04249145
17MP0004084_abnormal_cardiac_muscle1.99409697
18MP0002837_dystrophic_cardiac_calcinosis1.93804372
19MP0005375_adipose_tissue_phenotype1.93261848
20MP0002332_abnormal_exercise_endurance1.92655132
21MP0003279_aneurysm1.92015687
22MP0003300_gastrointestinal_ulcer1.86610492
23MP0004036_abnormal_muscle_relaxation1.80612267
24MP0002971_abnormal_brown_adipose1.79895460
25MP0000759_abnormal_skeletal_muscle1.71655785
26MP0002106_abnormal_muscle_physiology1.70806975
27MP0000747_muscle_weakness1.69612797
28MP0005451_abnormal_body_composition1.68733065
29MP0003828_pulmonary_edema1.68573810
30MP0005330_cardiomyopathy1.65606167
31MP0004145_abnormal_muscle_electrophysio1.65054891
32MP0005503_abnormal_tendon_morphology1.61473242
33MP0001879_abnormal_lymphatic_vessel1.61012448
34MP0003646_muscle_fatigue1.59382778
35MP0003303_peritoneal_inflammation1.50561869
36MP0000465_gastrointestinal_hemorrhage1.50162211
37MP0000013_abnormal_adipose_tissue1.49010349
38MP0002877_abnormal_melanocyte_morpholog1.48565710
39MP0000343_altered_response_to1.48043206
40MP0010630_abnormal_cardiac_muscle1.46988653
41MP0000920_abnormal_myelination1.46982541
42MP0003091_abnormal_cell_migration1.46605044
43MP0005620_abnormal_muscle_contractility1.45692415
44MP0005369_muscle_phenotype1.45631424
45MP0001958_emphysema1.43637192
46MP0003566_abnormal_cell_adhesion1.43594390
47MP0002108_abnormal_muscle_morphology1.42654005
48MP0000003_abnormal_adipose_tissue1.41758655
49MP0002972_abnormal_cardiac_muscle1.41603886
50MP0005164_abnormal_response_to1.40131467
51MP0005409_darkened_coat_color1.36179126
52MP0000569_abnormal_digit_pigmentation1.35024218
53MP0004510_myositis1.33830882
54MP0008775_abnormal_heart_ventricle1.32736114
55MP0001835_abnormal_antigen_presentation1.32580708
56MP0003724_increased_susceptibility_to1.32026008
57MP0005464_abnormal_platelet_physiology1.30493446
58MP0001299_abnormal_eye_distance/1.27030832
59MP0010368_abnormal_lymphatic_system1.25096291
60MP0009785_altered_susceptibility_to1.24263777
61MP0004883_abnormal_blood_vessel1.23905947
62MP0005058_abnormal_lysosome_morphology1.23055346
63MP0003045_fibrosis1.21874574
64MP0003690_abnormal_glial_cell1.21626597
65MP0009278_abnormal_bone_marrow1.19539648
66MP0006138_congestive_heart_failure1.19193485
67MP0001533_abnormal_skeleton_physiology1.18762547
68MP0002998_abnormal_bone_remodeling1.18114109
69MP0001544_abnormal_cardiovascular_syste1.16626117
70MP0005385_cardiovascular_system_phenoty1.16626117
71MP0004215_abnormal_myocardial_fiber1.16177359
72MP0006054_spinal_hemorrhage1.14865297
73MP0008004_abnormal_stomach_pH1.14424183
74MP0009384_cardiac_valve_regurgitation1.12595473
75MP0005165_increased_susceptibility_to1.11541677
76MP0000767_abnormal_smooth_muscle1.09778811
77MP0005387_immune_system_phenotype1.07884174
78MP0001790_abnormal_immune_system1.07884174
79MP0002148_abnormal_hypersensitivity_rea1.07613564
80MP0002269_muscular_atrophy1.07314699
81MP0002295_abnormal_pulmonary_circulatio1.06500386
82MP0004134_abnormal_chest_morphology1.06455492
83MP0009764_decreased_sensitivity_to1.05590987
84MP0005000_abnormal_immune_tolerance1.02817135
85MP0003075_altered_response_to1.02594731
86MP0002127_abnormal_cardiovascular_syste1.02053921
87MP0004233_abnormal_muscle_weight0.99856214
88MP0003448_altered_tumor_morphology0.98105422
89MP0003656_abnormal_erythrocyte_physiolo0.97977709
90MP0005595_abnormal_vascular_smooth0.96684187
91MP0005166_decreased_susceptibility_to0.96285505
92MP0002933_joint_inflammation0.94755228
93MP0005025_abnormal_response_to0.94070818
94MP0009840_abnormal_foam_cell0.93423486
95MP0002896_abnormal_bone_mineralization0.92238812
96MP0009115_abnormal_fat_cell0.91443285
97MP0002166_altered_tumor_susceptibility0.90207486
98MP0002128_abnormal_blood_circulation0.88570819
99MP0003221_abnormal_cardiomyocyte_apopto0.87423360
100MP0008260_abnormal_autophagy0.87187181
101MP0005076_abnormal_cell_differentiation0.86082560
102MP0000858_altered_metastatic_potential0.86069646
103MP0004484_altered_response_of0.84612405
104MP0005167_abnormal_blood-brain_barrier0.83759647
105MP0001542_abnormal_bone_strength0.83585000
106MP0003191_abnormal_cellular_cholesterol0.82346352
107MP0004947_skin_inflammation0.82309976
108MP0003436_decreased_susceptibility_to0.81708829
109MP0005334_abnormal_fat_pad0.81684775
110MP0010352_gastrointestinal_tract_polyps0.80927107
111MP0009780_abnormal_chondrocyte_physiolo0.80546648
112MP0006082_CNS_inflammation0.79511372
113MP0001851_eye_inflammation0.78609566
114MP0000249_abnormal_blood_vessel0.78503571
115MP0001614_abnormal_blood_vessel0.75362630
116MP0009250_abnormal_appendicular_skeleto0.74878929
117MP0005388_respiratory_system_phenotype0.73427916
118MP0002133_abnormal_respiratory_system0.73427916
119MP0002060_abnormal_skin_morphology0.72015575
120MP0003698_abnormal_male_reproductive0.71110758
121MP0002419_abnormal_innate_immunity0.70897863
122MP0002168_other_aberrant_phenotype0.69570539
123MP0004147_increased_porphyrin_level0.69184137
124MP0000685_abnormal_immune_system0.69107342
125MP0005390_skeleton_phenotype0.68731871
126MP0005023_abnormal_wound_healing0.66130500
127MP0002234_abnormal_pharynx_morphology0.64952406

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.66569157
2Difficulty running (HP:0009046)4.66480118
3Muscle fiber inclusion bodies (HP:0100299)4.56465141
4Muscle fiber splitting (HP:0003555)4.45767458
5Hyporeflexia of lower limbs (HP:0002600)4.34480556
6Type 1 muscle fiber predominance (HP:0003803)4.34228033
7Nemaline bodies (HP:0003798)4.16726030
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.90507584
9Absent/shortened dynein arms (HP:0200106)3.83960711
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.83960711
11Round ear (HP:0100830)3.54995669
12Distal arthrogryposis (HP:0005684)3.51475525
13Muscle hypertrophy of the lower extremities (HP:0008968)3.45211076
14Gowers sign (HP:0003391)3.44016514
15Premature rupture of membranes (HP:0001788)3.43794455
16Increased connective tissue (HP:0009025)3.40650543
17Calf muscle hypertrophy (HP:0008981)3.40448119
18Difficulty climbing stairs (HP:0003551)3.34778870
19Exercise-induced myalgia (HP:0003738)3.30883995
20Abnormality of the calf musculature (HP:0001430)3.22812497
21Spinal rigidity (HP:0003306)3.18172683
22Exercise-induced muscle cramps (HP:0003710)3.17685344
23Ulnar deviation of the wrist (HP:0003049)3.06797176
24EMG: myopathic abnormalities (HP:0003458)2.98938610
25Spontaneous hematomas (HP:0007420)2.94561875
26Abnormality of skeletal muscle fiber size (HP:0012084)2.79989627
27Scapular winging (HP:0003691)2.76753202
28Increased variability in muscle fiber diameter (HP:0003557)2.76678572
29Abnormality of the neuromuscular junction (HP:0003398)2.75693221
30Fatigable weakness (HP:0003473)2.75693221
31Eczematoid dermatitis (HP:0000976)2.74729756
32Asymmetric septal hypertrophy (HP:0001670)2.71840545
33Weak cry (HP:0001612)2.70718829
34Easy fatigability (HP:0003388)2.66509642
35Centrally nucleated skeletal muscle fibers (HP:0003687)2.63260317
36Protrusio acetabuli (HP:0003179)2.62700399
37Facial diplegia (HP:0001349)2.59328105
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.58001774
39Osteolytic defects of the hand bones (HP:0009699)2.58001774
40Myoglobinuria (HP:0002913)2.55618378
41Aortic aneurysm (HP:0004942)2.55150023
42Abnormality of the nasal mucosa (HP:0000433)2.53270231
43Nasal polyposis (HP:0100582)2.52936037
44Bundle branch block (HP:0011710)2.51807146
45Generalized muscle weakness (HP:0003324)2.50596003
46Cerebral aneurysm (HP:0004944)2.49769912
47Hypoplastic ischia (HP:0003175)2.48749610
48Sudden death (HP:0001699)2.47935458
49Aortic dissection (HP:0002647)2.47573808
50Mildly elevated creatine phosphokinase (HP:0008180)2.43384622
51Malignant hyperthermia (HP:0002047)2.40924099
52Akinesia (HP:0002304)2.39008595
53Hematochezia (HP:0002573)2.32474658
54Lipoatrophy (HP:0100578)2.31248296
55Papillary thyroid carcinoma (HP:0002895)2.28974205
56Abnormal respiratory motile cilium physiology (HP:0012261)2.28637168
57Fetal akinesia sequence (HP:0001989)2.28400895
58Atrophic scars (HP:0001075)2.26497252
59Myopathic facies (HP:0002058)2.25968595
60Neck muscle weakness (HP:0000467)2.24323202
61Neurofibrillary tangles (HP:0002185)2.22936631
62Recurrent abscess formation (HP:0002722)2.20306087
63Bell-shaped thorax (HP:0001591)2.19795776
64Frequent falls (HP:0002359)2.19072233
65Abnormality of the ischium (HP:0003174)2.18319237
66Broad metatarsal (HP:0001783)2.16975480
67Spondylolisthesis (HP:0003302)2.16699834
68Absent phalangeal crease (HP:0006109)2.16315271
69Popliteal pterygium (HP:0009756)2.16314770
70Thick nail (HP:0001805)2.15525189
71Aplasia of the musculature (HP:0100854)2.15272790
72Calcaneovalgus deformity (HP:0001848)2.14995919
73Abnormal finger flexion creases (HP:0006143)2.14678400
74Distal lower limb muscle weakness (HP:0009053)2.14108616
75Right ventricular cardiomyopathy (HP:0011663)2.14097579
76Aneurysm (HP:0002617)2.13701738
77Dilatation of the ascending aorta (HP:0005111)2.11124401
78Bulbar palsy (HP:0001283)2.09486029
79Disinhibition (HP:0000734)2.08615796
80Abnormality of the left ventricular outflow tract (HP:0011103)2.06272479
81Subaortic stenosis (HP:0001682)2.06272479
82Abnormality of macrophages (HP:0004311)2.04388999
83Orchitis (HP:0100796)2.03013566
84Myositis (HP:0100614)2.02086494
85Ventricular tachycardia (HP:0004756)2.01851792
86Slender build (HP:0001533)2.01826345
87Axonal loss (HP:0003447)1.98397364
88Recurrent bacterial skin infections (HP:0005406)1.97220996
89Deformed tarsal bones (HP:0008119)1.95088787
90Polycythemia (HP:0001901)1.95007117
91Muscular dystrophy (HP:0003560)1.93965587
92Pterygium (HP:0001059)1.93272715
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92963188
94Overgrowth (HP:0001548)1.91854320
95Muscle stiffness (HP:0003552)1.91779399
96Abnormality of placental membranes (HP:0011409)1.91164295
97Amniotic constriction ring (HP:0009775)1.91164295
98Rhabdomyolysis (HP:0003201)1.90297449
99Hip contracture (HP:0003273)1.89203410
100Acanthosis nigricans (HP:0000956)1.87463168
101Arterial tortuosity (HP:0005116)1.87241374
102Wormian bones (HP:0002645)1.86349193
103Ventricular arrhythmia (HP:0004308)1.84861834
104Shallow orbits (HP:0000586)1.84701445
105Lower limb amyotrophy (HP:0007210)1.84455640
106Abnormal respiratory epithelium morphology (HP:0012253)1.84421990
107Abnormal respiratory motile cilium morphology (HP:0005938)1.84421990
108Myotonia (HP:0002486)1.84356435
109Gingivitis (HP:0000230)1.83818792
110Vascular tortuosity (HP:0004948)1.83333067
111Gingival bleeding (HP:0000225)1.83105809
112Amyloidosis (HP:0011034)1.82882593
113Mitral stenosis (HP:0001718)1.82543707
114Distal lower limb amyotrophy (HP:0008944)1.82348424
115Increased cerebral lipofuscin (HP:0011813)1.81447195
116Buphthalmos (HP:0000557)1.80854402
117Peritonitis (HP:0002586)1.80661666
118Abnormality of glycolipid metabolism (HP:0010969)1.78765995
119Abnormality of liposaccharide metabolism (HP:0010968)1.78765995
120Abnormality of glycosphingolipid metabolism (HP:0004343)1.78765995
121Back pain (HP:0003418)1.78398562
122Striae distensae (HP:0001065)1.78182959
123EMG: neuropathic changes (HP:0003445)1.77790286
124Prolonged bleeding time (HP:0003010)1.76546404
125Rimmed vacuoles (HP:0003805)1.76182735
126Thin ribs (HP:0000883)1.75707897
127Exostoses (HP:0100777)1.75248953
128Increased density of long bones (HP:0006392)1.73509599
129Cerebral inclusion bodies (HP:0100314)1.73178235
130Dilated cardiomyopathy (HP:0001644)1.73113835
131Rhinitis (HP:0012384)1.71579287
132Mitral valve prolapse (HP:0001634)1.70734505
133Chest pain (HP:0100749)1.70144397
134Myocardial infarction (HP:0001658)1.68640822
135Recurrent gram-negative bacterial infections (HP:0005420)1.68279990
136Gastrointestinal infarctions (HP:0005244)1.64926841
137Optic neuritis (HP:0100653)1.64751292
138Retrobulbar optic neuritis (HP:0100654)1.64751292
139Abnormality of the endocardium (HP:0004306)1.63467797
140Metaphyseal dysplasia (HP:0100255)1.63273782
141Vertebral compression fractures (HP:0002953)1.60797408
142Fragile skin (HP:0001030)1.60699821
143Hypoplasia of the iris (HP:0007676)1.60661127
144Follicular hyperkeratosis (HP:0007502)1.60523978
145Atrial fibrillation (HP:0005110)1.58070108
146Increased IgE level (HP:0003212)1.56915288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.27493149
2PDK44.27493149
3TRIB33.58980776
4PDK23.30918446
5EPHB12.99594430
6TTN2.97683461
7STK392.65665614
8DMPK2.08069051
9TESK12.03536561
10TGFBR21.95851246
11OBSCN1.85351395
12MAP3K61.77110550
13WNK41.70414706
14CAMK1G1.66683534
15ICK1.65172467
16STK31.61529149
17MOS1.58749842
18PKN21.55991776
19MAP2K31.53453474
20PTK2B1.51552452
21CAMK1D1.50924684
22PRPF4B1.41590101
23ZAP701.38381581
24PRKD31.35673907
25PHKG21.35358752
26PHKG11.35358752
27MAP3K131.34982503
28PIK3CG1.33898739
29RIPK11.31305850
30EPHB21.28884228
31NEK91.28492445
32MUSK1.28411349
33TBK11.23820456
34KSR21.21001355
35TIE11.19696124
36WNK11.18525790
37PIK3CA1.15104467
38RIPK41.13657051
39PTK61.09876627
40ERN11.09824023
41LATS11.09017343
42KSR11.08264749
43PDGFRA1.07687352
44MAP3K71.06757030
45FES1.06423686
46PKN11.06383837
47MAP3K21.05951600
48SGK31.05833842
49LRRK21.05411979
50LIMK11.03763140
51DDR21.03382099
52AKT30.99579658
53PDGFRB0.99406352
54TRPM70.97357856
55ILK0.96386009
56SIK10.94967206
57DYRK1B0.94802328
58STK100.93387819
59MET0.92848241
60JAK20.91920680
61MARK10.91442898
62CAMKK20.90473491
63CDK60.90313316
64FGFR20.89298436
65MAPK70.88569639
66JAK10.87885316
67PAK20.86636797
68HCK0.86474915
69SGK20.86443872
70STK380.86229715
71BMPR20.85101253
72KDR0.82486722
73IRAK10.82139994
74YES10.78949821
75PRKD10.78939500
76TYK20.78473691
77MAP3K10.76826482
78CSK0.76594572
79IKBKE0.76058024
80FGFR40.74462534
81FGFR30.74207354
82EPHA30.74046519
83CDC42BPA0.72780347
84STK240.71958012
85MAP3K50.71377631
86ROCK10.69980977
87PDK10.67775777
88NUAK10.67241993
89PDPK10.65415324
90SIK30.64301891
91LMTK20.63983885
92PIM20.63689084
93PAK30.62542633
94IRAK30.61819631
95MAP3K100.59733320
96MAPK120.59023220
97TAOK10.58954959
98MAPK40.58911427
99FLT30.58848210
100PRKAA20.58706217
101PBK0.58407992
102RET0.58321145
103MAP2K40.58249336
104FRK0.57851501
105FGR0.56210875
106GSK3A0.56086719
107MAPKAPK50.55913483
108MAPKAPK30.55825694
109CDK90.55169349
110FER0.54998094
111MAP2K10.54233529
112ROCK20.53495182
113TYRO30.52300674
114PTK20.52169418
115RAF10.51944304
116IRAK40.51879552
117KIT0.51310141
118MTOR0.51185032
119BMX0.50512140
120TEC0.50385731
121SYK0.48896693
122BTK0.48878204
123STK38L0.48176686
124LATS20.47215507
125MAP3K140.46952723
126INSR0.46939349
127TXK0.46171689
128PAK40.46162766
129PRKG20.45920982
130JAK30.45376034
131MAP3K120.43967316
132EGFR0.43810196
133MYLK0.43572380
134CSF1R0.43230343
135GRK70.41908718
136MST1R0.41623354
137BCR0.41204372
138ABL10.41002322
139PRKCQ0.40045843
140MARK20.36493645
141INSRR0.35397632
142BLK0.35052478
143ERBB30.33108692
144MAP3K30.30682919

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.25310846
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.99342213
3Viral myocarditis_Homo sapiens_hsa054161.91218940
4ECM-receptor interaction_Homo sapiens_hsa045121.90396467
5Fatty acid biosynthesis_Homo sapiens_hsa000611.89339946
6Dilated cardiomyopathy_Homo sapiens_hsa054141.87939061
7Propanoate metabolism_Homo sapiens_hsa006401.84378807
8Focal adhesion_Homo sapiens_hsa045101.83657017
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65948121
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64601405
11PPAR signaling pathway_Homo sapiens_hsa033201.59320385
12Toxoplasmosis_Homo sapiens_hsa051451.56626375
13Dorso-ventral axis formation_Homo sapiens_hsa043201.55624477
14Fatty acid metabolism_Homo sapiens_hsa012121.52124162
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47876262
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.46091667
17Malaria_Homo sapiens_hsa051441.45001427
18Osteoclast differentiation_Homo sapiens_hsa043801.41307313
19Renal cell carcinoma_Homo sapiens_hsa052111.33875747
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.33711552
21Adherens junction_Homo sapiens_hsa045201.29714867
22Proteoglycans in cancer_Homo sapiens_hsa052051.25920233
23Amoebiasis_Homo sapiens_hsa051461.21833480
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21183687
25Fatty acid degradation_Homo sapiens_hsa000711.19627949
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19165919
27Leishmaniasis_Homo sapiens_hsa051401.16912431
28Salmonella infection_Homo sapiens_hsa051321.14915258
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14858641
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13646003
31Circadian rhythm_Homo sapiens_hsa047101.12782585
32Platelet activation_Homo sapiens_hsa046111.12244354
33AMPK signaling pathway_Homo sapiens_hsa041521.11776278
34Small cell lung cancer_Homo sapiens_hsa052221.10187864
35Pertussis_Homo sapiens_hsa051331.08022315
36Insulin resistance_Homo sapiens_hsa049311.07843673
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07238246
38B cell receptor signaling pathway_Homo sapiens_hsa046621.05670924
39Chronic myeloid leukemia_Homo sapiens_hsa052201.05121857
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04366254
41* Endocytosis_Homo sapiens_hsa041441.03826748
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.03802081
43Tight junction_Homo sapiens_hsa045301.03672211
44Fatty acid elongation_Homo sapiens_hsa000621.01975328
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01520107
46Pancreatic cancer_Homo sapiens_hsa052121.01420059
47Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98988532
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97366110
49Lysosome_Homo sapiens_hsa041420.96443197
50Prolactin signaling pathway_Homo sapiens_hsa049170.95850615
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.94765072
52VEGF signaling pathway_Homo sapiens_hsa043700.91562673
53Other glycan degradation_Homo sapiens_hsa005110.91260744
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91062279
55Cardiac muscle contraction_Homo sapiens_hsa042600.90946603
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90943751
57Endometrial cancer_Homo sapiens_hsa052130.90253826
58Axon guidance_Homo sapiens_hsa043600.89988176
59Shigellosis_Homo sapiens_hsa051310.88947864
60Staphylococcus aureus infection_Homo sapiens_hsa051500.88916934
61FoxO signaling pathway_Homo sapiens_hsa040680.86560098
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85356417
63Renin secretion_Homo sapiens_hsa049240.84954026
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84885483
65GnRH signaling pathway_Homo sapiens_hsa049120.84384859
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83462619
67Sulfur metabolism_Homo sapiens_hsa009200.83436418
68Influenza A_Homo sapiens_hsa051640.83208331
69Non-small cell lung cancer_Homo sapiens_hsa052230.83129490
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.81557823
71Phagosome_Homo sapiens_hsa041450.81051759
72Tuberculosis_Homo sapiens_hsa051520.80822055
73Pyruvate metabolism_Homo sapiens_hsa006200.78723788
74Protein digestion and absorption_Homo sapiens_hsa049740.77642403
75T cell receptor signaling pathway_Homo sapiens_hsa046600.76314229
76Legionellosis_Homo sapiens_hsa051340.75633944
77TNF signaling pathway_Homo sapiens_hsa046680.75319084
78Glucagon signaling pathway_Homo sapiens_hsa049220.75177849
79mTOR signaling pathway_Homo sapiens_hsa041500.73016309
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72499921
81Measles_Homo sapiens_hsa051620.72285322
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72162010
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71689388
84Insulin signaling pathway_Homo sapiens_hsa049100.71172663
85Chemokine signaling pathway_Homo sapiens_hsa040620.71141091
86Ether lipid metabolism_Homo sapiens_hsa005650.71042430
87Steroid biosynthesis_Homo sapiens_hsa001000.69123007
88Oxytocin signaling pathway_Homo sapiens_hsa049210.68875214
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.67828857
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66073907
91Choline metabolism in cancer_Homo sapiens_hsa052310.65353647
92Apoptosis_Homo sapiens_hsa042100.64531860
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.63929682
94HIF-1 signaling pathway_Homo sapiens_hsa040660.63676914
95Prostate cancer_Homo sapiens_hsa052150.61666962
96Acute myeloid leukemia_Homo sapiens_hsa052210.61544274
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61084999
98MAPK signaling pathway_Homo sapiens_hsa040100.60754923
99Glycerolipid metabolism_Homo sapiens_hsa005610.60590496
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60244324
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59805233
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58542732
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.57695074
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56544738
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.56165254
106African trypanosomiasis_Homo sapiens_hsa051430.56000235
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55202136
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54955315
109Glioma_Homo sapiens_hsa052140.54779345
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54511265
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54343860
112Gap junction_Homo sapiens_hsa045400.54246874
113Bladder cancer_Homo sapiens_hsa052190.54060748
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53070422
115Sphingolipid metabolism_Homo sapiens_hsa006000.52991600
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52423746
117Long-term depression_Homo sapiens_hsa047300.51957792
118ErbB signaling pathway_Homo sapiens_hsa040120.51893997
119MicroRNAs in cancer_Homo sapiens_hsa052060.51617121
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51090453
121Rap1 signaling pathway_Homo sapiens_hsa040150.50247341
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48402498
123Ras signaling pathway_Homo sapiens_hsa040140.48224666
124Hepatitis C_Homo sapiens_hsa051600.48216011
125Pathways in cancer_Homo sapiens_hsa052000.47974861
126Hepatitis B_Homo sapiens_hsa051610.47623894
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47114812
128Hematopoietic cell lineage_Homo sapiens_hsa046400.46411573
129Rheumatoid arthritis_Homo sapiens_hsa053230.46350624

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