SH3PXD2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.19333393
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.19333393
3modulation by symbiont of host immune response (GO:0052553)4.19333393
4positive regulation by symbiont of host defense response (GO:0052509)4.19333393
5modulation by symbiont of host defense response (GO:0052031)4.19333393
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.19333393
7paraxial mesoderm development (GO:0048339)4.15669861
8axon extension involved in axon guidance (GO:0048846)3.57548114
9neuron projection extension involved in neuron projection guidance (GO:1902284)3.57548114
10cell adhesion mediated by integrin (GO:0033627)3.53232960
11barbed-end actin filament capping (GO:0051016)3.46835105
12cell migration involved in heart development (GO:0060973)3.43657987
13Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.39373303
14positive regulation of heat generation (GO:0031652)3.32955196
15vascular endothelial growth factor signaling pathway (GO:0038084)3.31703158
16wound healing, spreading of epidermal cells (GO:0035313)3.24598433
17regulation of establishment of planar polarity (GO:0090175)3.23827765
18semaphorin-plexin signaling pathway (GO:0071526)3.19963864
19mesenchymal-epithelial cell signaling (GO:0060638)3.14793211
20chondrocyte proliferation (GO:0035988)3.12976835
21convergent extension (GO:0060026)3.09569984
22glial cell migration (GO:0008347)3.09365734
23cell migration involved in sprouting angiogenesis (GO:0002042)3.09104918
24response to host immune response (GO:0052572)3.02892240
25response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.02892240
26epithelial cell-cell adhesion (GO:0090136)3.02529649
27regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.02133593
28dermatan sulfate metabolic process (GO:0030205)2.97420333
29metanephric mesenchyme development (GO:0072075)2.96590108
30kidney mesenchyme development (GO:0072074)2.91513545
31cytoskeletal anchoring at plasma membrane (GO:0007016)2.91009000
32response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90996483
33response to host (GO:0075136)2.90996483
34response to host defenses (GO:0052200)2.90996483
35positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.90973759
36protein localization to endosome (GO:0036010)2.89850493
37collagen fibril organization (GO:0030199)2.89399557
38regulation of fever generation (GO:0031620)2.88752984
39growth hormone receptor signaling pathway (GO:0060396)2.88049743
40cell-substrate junction assembly (GO:0007044)2.87576927
41endothelial cell morphogenesis (GO:0001886)2.87094699
42macrophage activation involved in immune response (GO:0002281)2.85102220
43planar cell polarity pathway involved in neural tube closure (GO:0090179)2.84929376
44cellular response to interferon-alpha (GO:0035457)2.84885948
45apoptotic cell clearance (GO:0043277)2.84558444
46endodermal cell differentiation (GO:0035987)2.83391188
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82976588
48cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.82917762
49adherens junction assembly (GO:0034333)2.81750768
50non-canonical Wnt signaling pathway (GO:0035567)2.81586615
51notochord development (GO:0030903)2.81198841
52regulation of axon extension involved in axon guidance (GO:0048841)2.79233228
53regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.78021209
54cochlea morphogenesis (GO:0090103)2.77375361
55dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.77184496
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.76260991
57heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.73369271
58vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.72785439
59regulation of mononuclear cell migration (GO:0071675)2.72411129
60protein retention in ER lumen (GO:0006621)2.71717986
61chondrocyte development (GO:0002063)2.71399334
62negative regulation of cartilage development (GO:0061037)2.70147519
63extracellular fibril organization (GO:0043206)2.69855853
64stress fiber assembly (GO:0043149)2.67262032
65endothelial cell chemotaxis (GO:0035767)2.64338104
66positive regulation of cellular amide metabolic process (GO:0034250)2.64261454
67substrate-dependent cell migration (GO:0006929)2.63880371
68maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.63592264
69regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.63244868
70positive regulation of macrophage cytokine production (GO:0060907)2.62986522
71hippo signaling (GO:0035329)2.62636814
72establishment of planar polarity (GO:0001736)2.62486626
73establishment of tissue polarity (GO:0007164)2.62486626
74positive regulation of SMAD protein import into nucleus (GO:0060391)2.62402393
75regulation of early endosome to late endosome transport (GO:2000641)2.61792349
76Notch signaling involved in heart development (GO:0061314)2.60769121
77axon extension (GO:0048675)2.60058909
78regulation of interferon-beta biosynthetic process (GO:0045357)2.58994628
79regulation of heat generation (GO:0031650)2.57722710
80* extracellular matrix organization (GO:0030198)2.57540292
81adhesion of symbiont to host cell (GO:0044650)2.56815399
82virion attachment to host cell (GO:0019062)2.56815399
83regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.56395667
84* extracellular structure organization (GO:0043062)2.56374142
85positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.56171053
86bone trabecula formation (GO:0060346)2.56097682
87regulation of macrophage cytokine production (GO:0010935)2.55798692
88wound healing, spreading of cells (GO:0044319)2.55466776
89camera-type eye morphogenesis (GO:0048593)2.55408925
90collagen catabolic process (GO:0030574)2.55333244
91I-kappaB phosphorylation (GO:0007252)2.55043740
92negative regulation of chondrocyte differentiation (GO:0032331)2.54147835
93adhesion of symbiont to host (GO:0044406)2.54130689
94cell surface receptor signaling pathway involved in heart development (GO:0061311)2.53797582
95negative regulation of axon extension involved in axon guidance (GO:0048843)2.53620092
96positive regulation vascular endothelial growth factor production (GO:0010575)2.53380847
97chondroitin sulfate biosynthetic process (GO:0030206)2.53060020
98venous blood vessel morphogenesis (GO:0048845)2.52996699
99glomerular visceral epithelial cell development (GO:0072015)2.52806568
100collagen metabolic process (GO:0032963)2.52240310
101regulation of integrin activation (GO:0033623)2.50638636
102glomerular basement membrane development (GO:0032836)2.49990117
103microglial cell activation (GO:0001774)2.49788211
104protein heterotrimerization (GO:0070208)2.48179673
105positive regulation of epithelial to mesenchymal transition (GO:0010718)2.47627262
106sequestering of extracellular ligand from receptor (GO:0035581)2.47182380
107polarized epithelial cell differentiation (GO:0030859)2.45580672
108craniofacial suture morphogenesis (GO:0097094)2.43796287
109outer ear morphogenesis (GO:0042473)2.43678261
110cell proliferation involved in metanephros development (GO:0072203)2.43431250
111regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.42698553
112basement membrane organization (GO:0071711)2.41835049
113regulation of axon guidance (GO:1902667)2.40712092
114negative regulation of stem cell proliferation (GO:2000647)2.40441646
115cellular response to growth hormone stimulus (GO:0071378)2.39753730
116lateral sprouting from an epithelium (GO:0060601)2.39560521
117cellular extravasation (GO:0045123)2.39433908
118tooth mineralization (GO:0034505)2.38262304
119apical protein localization (GO:0045176)2.38257897
120negative regulation of smooth muscle cell migration (GO:0014912)2.38164448
121positive regulation of blood vessel endothelial cell migration (GO:0043536)2.37884766
122extracellular matrix assembly (GO:0085029)2.37445883
123COPI coating of Golgi vesicle (GO:0048205)2.37367449
124positive regulation of chemokine biosynthetic process (GO:0045080)2.36061557
125multicellular organismal macromolecule metabolic process (GO:0044259)2.35260461
126monocyte chemotaxis (GO:0002548)2.31776489
127negative regulation of fatty acid transport (GO:2000192)2.31529157
128branching involved in salivary gland morphogenesis (GO:0060445)2.30508926
129negative regulation of catenin import into nucleus (GO:0035414)2.29005790
130positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.27393069
131skin morphogenesis (GO:0043589)2.26364120
132multicellular organismal catabolic process (GO:0044243)2.25762040
133positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.21763293
134ganglion development (GO:0061548)2.21531605
135regulation of vascular endothelial growth factor production (GO:0010574)2.20844791
136retina vasculature morphogenesis in camera-type eye (GO:0061299)2.19713222
137hyaluronan catabolic process (GO:0030214)2.19698770
138regulation of chemokine-mediated signaling pathway (GO:0070099)2.19161597
139neutrophil activation involved in immune response (GO:0002283)2.17651635
140regulation of monocyte chemotaxis (GO:0090025)2.17531513
141* extracellular matrix disassembly (GO:0022617)2.17336417
142multicellular organismal metabolic process (GO:0044236)2.16170345
143detection of molecule of bacterial origin (GO:0032490)2.15493352
144lymphangiogenesis (GO:0001946)2.14493871
145substrate adhesion-dependent cell spreading (GO:0034446)2.13526328
146negative chemotaxis (GO:0050919)2.13006108
147face morphogenesis (GO:0060325)2.12915507
148hemidesmosome assembly (GO:0031581)2.12863841
149response to fluid shear stress (GO:0034405)2.12119669
150regulation of non-canonical Wnt signaling pathway (GO:2000050)2.11114736
151dermatan sulfate biosynthetic process (GO:0030208)2.09507642
152cartilage morphogenesis (GO:0060536)2.09394733
153response to cholesterol (GO:0070723)2.08769823
154cytoplasmic mRNA processing body assembly (GO:0033962)2.06163417
155G-protein coupled receptor internalization (GO:0002031)2.05477994
156cellular response to vitamin (GO:0071295)2.05418593
157response to muramyl dipeptide (GO:0032495)2.04537326
158positive regulation of interleukin-1 beta secretion (GO:0050718)2.03491619
159G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.03407042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.42951383
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.85214327
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.88529978
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.71246206
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.63009019
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56243395
7CLOCK_20551151_ChIP-Seq_293T_Human2.53538867
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.29816546
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22686385
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.22564768
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.11550228
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.11456496
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03819428
14ZFP281_18757296_ChIP-ChIP_E14_Mouse2.01692608
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.98560055
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92014809
17* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.85504460
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80849786
19* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80574172
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77422067
21NFIB_24661679_ChIP-Seq_LUNG_Mouse1.76686360
22* CJUN_26792858_Chip-Seq_BT549_Human1.76205711
23VDR_24787735_ChIP-Seq_THP-1_Human1.75147846
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73207747
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70973468
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.70702846
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70015801
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68956291
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68894838
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67385622
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.64685460
32* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62890673
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60823465
34* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60466091
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60175939
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54660632
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53236987
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.51369080
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.51369080
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.51369080
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.51184673
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.50423646
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48935623
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48113445
45* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47377710
46TP53_16413492_ChIP-PET_HCT116_Human1.46835111
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.45355583
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45097366
49* BRD4_25478319_ChIP-Seq_HGPS_Human1.45046792
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44702817
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43507678
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41721466
53TP53_18474530_ChIP-ChIP_U2OS_Human1.41425255
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39954386
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38236113
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37528076
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36332535
58UBF1/2_26484160_Chip-Seq_HMECs_Human1.35945411
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35258584
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35258584
61LXR_22292898_ChIP-Seq_THP-1_Human1.34724134
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32729713
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32425673
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32346540
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.31147030
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30737008
67RXR_22108803_ChIP-Seq_LS180_Human1.29030143
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.28406271
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28062271
70* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27616556
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26697462
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26697462
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26330592
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26154867
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.25583918
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25135634
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24505480
78TP53_22127205_ChIP-Seq_IMR90_Human1.23061434
79* RING1B_27294783_Chip-Seq_ESCs_Mouse1.22414793
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21742385
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21641799
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21574989
83* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20728950
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20276412
85RACK7_27058665_Chip-Seq_MCF-7_Human1.20081805
86SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19843962
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19695265
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.19369739
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19353636
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18952795
91ZNF263_19887448_ChIP-Seq_K562_Human1.18224818
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17871440
93AHR_22903824_ChIP-Seq_MCF-7_Human1.16866985
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.15379114
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.14717673
96OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14488593
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.13621429
98SMC1_22415368_ChIP-Seq_MEFs_Mouse1.12804244
99* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12363703
100JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11995778
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.11705545
102TBX20_22328084_ChIP-Seq_HEART_Mouse1.11705545
103AR_21572438_ChIP-Seq_LNCaP_Human1.11602748
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11588194
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11588194
106TP53_23651856_ChIP-Seq_MEFs_Mouse1.11121651
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08854208
108TCF4_18268006_ChIP-ChIP_LS174T_Human1.08756996
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08345044
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07442293
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07353199
112* ELK3_25401928_ChIP-Seq_HUVEC_Human1.07193510
113PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.07091741
114* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06646484
115* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06007832
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.05579350
117* KDM2B_26808549_Chip-Seq_K562_Human1.05565218
118SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03544360
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03314766
120SPI1_23127762_ChIP-Seq_K562_Human1.03245709
121SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03115409
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03051765
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.02880205
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02626548
125NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02471514
126* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02242515
127* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01108024
128JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00552353
129* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00076161
130JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99628029
131HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98955834
132* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98664156
133ISL1_27105846_Chip-Seq_CPCs_Mouse0.98348725
134SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97912775
135SA1_22415368_ChIP-Seq_MEFs_Mouse0.97611115
136KDM2B_26808549_Chip-Seq_JURKAT_Human0.97288089
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96421101
138* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96093251
139GBX2_23144817_ChIP-Seq_PC3_Human0.95638585
140ESR2_21235772_ChIP-Seq_MCF-7_Human0.94009495
141DROSHA_22980978_ChIP-Seq_HELA_Human0.93395304
142* RING1B_27294783_Chip-Seq_NPCs_Mouse0.93059816
143KDM2B_26808549_Chip-Seq_DND41_Human0.92518326
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90631072

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.50198684
2MP0000569_abnormal_digit_pigmentation4.48808839
3MP0003705_abnormal_hypodermis_morpholog3.00542217
4MP0005503_abnormal_tendon_morphology2.90698547
5MP0005275_abnormal_skin_tensile2.46637112
6MP0003303_peritoneal_inflammation2.30392913
7MP0004272_abnormal_basement_membrane2.26150980
8MP0006054_spinal_hemorrhage2.24979479
9MP0003279_aneurysm2.20061582
10MP0002254_reproductive_system_inflammat2.10188858
11MP0001958_emphysema1.99885211
12MP0005623_abnormal_meninges_morphology1.99735675
13MP0000733_abnormal_muscle_development1.99708820
14MP0005058_abnormal_lysosome_morphology1.99344465
15MP0003566_abnormal_cell_adhesion1.97746285
16* MP0005257_abnormal_intraocular_pressure1.89498007
17MP0005076_abnormal_cell_differentiation1.89478184
18MP0004510_myositis1.85180549
19MP0005409_darkened_coat_color1.83404976
20MP0002998_abnormal_bone_remodeling1.79959944
21MP0005508_abnormal_skeleton_morphology1.72569369
22* MP0001849_ear_inflammation1.66992071
23MP0000537_abnormal_urethra_morphology1.65212869
24MP0003385_abnormal_body_wall1.62140757
25MP0003136_yellow_coat_color1.57149347
26MP0009278_abnormal_bone_marrow1.56088691
27MP0000566_synostosis1.56076584
28* MP0009250_abnormal_appendicular_skeleto1.55780792
29MP0009053_abnormal_anal_canal1.54998339
30MP0010030_abnormal_orbit_morphology1.54506936
31MP0003091_abnormal_cell_migration1.53289307
32MP0004858_abnormal_nervous_system1.53117792
33MP0003448_altered_tumor_morphology1.51856044
34MP0005390_skeleton_phenotype1.49167804
35MP0002877_abnormal_melanocyte_morpholog1.48004703
36MP0010352_gastrointestinal_tract_polyps1.46891192
37MP0003172_abnormal_lysosome_physiology1.45861687
38MP0005248_abnormal_Harderian_gland1.45701275
39MP0003436_decreased_susceptibility_to1.45688032
40MP0001533_abnormal_skeleton_physiology1.42995318
41MP0003300_gastrointestinal_ulcer1.42001860
42MP0002896_abnormal_bone_mineralization1.39779423
43MP0000762_abnormal_tongue_morphology1.37556507
44MP0002282_abnormal_trachea_morphology1.36123864
45MP0000767_abnormal_smooth_muscle1.32938726
46MP0005595_abnormal_vascular_smooth1.31628520
47MP0004233_abnormal_muscle_weight1.30976332
48MP0003045_fibrosis1.29781633
49MP0003828_pulmonary_edema1.26953503
50MP0002115_abnormal_skeleton_extremities1.25396571
51* MP0000428_abnormal_craniofacial_morphol1.24839520
52MP0010307_abnormal_tumor_latency1.23609229
53MP0009840_abnormal_foam_cell1.23407253
54MP0003941_abnormal_skin_development1.22705852
55MP0003755_abnormal_palate_morphology1.20898248
56MP0009384_cardiac_valve_regurgitation1.20851607
57MP0002060_abnormal_skin_morphology1.20712243
58MP0002419_abnormal_innate_immunity1.19664937
59* MP0002113_abnormal_skeleton_development1.17895606
60MP0000751_myopathy1.17585593
61MP0002938_white_spotting1.15571949
62MP0002277_abnormal_respiratory_mucosa1.15302305
63MP0003283_abnormal_digestive_organ1.15268413
64MP0000383_abnormal_hair_follicle1.15158400
65* MP0001299_abnormal_eye_distance/1.14949458
66* MP0000432_abnormal_head_morphology1.14405562
67MP0001542_abnormal_bone_strength1.12177865
68MP0002148_abnormal_hypersensitivity_rea1.10722620
69MP0002109_abnormal_limb_morphology1.10523203
70MP0002933_joint_inflammation1.08628152
71MP0005023_abnormal_wound_healing1.08576087
72MP0000163_abnormal_cartilage_morphology1.08498894
73MP0001835_abnormal_antigen_presentation1.07693074
74MP0004134_abnormal_chest_morphology1.07482299
75* MP0005197_abnormal_uvea_morphology1.05214347
76MP0003942_abnormal_urinary_system1.05125543
77* MP0002116_abnormal_craniofacial_bone1.04837084
78MP0004185_abnormal_adipocyte_glucose1.04167706
79MP0001346_abnormal_lacrimal_gland1.03267556
80MP0003115_abnormal_respiratory_system1.01858654
81MP0001851_eye_inflammation1.01526500
82MP0003634_abnormal_glial_cell1.01029621
83* MP0003795_abnormal_bone_structure1.00296442
84MP0000534_abnormal_ureter_morphology0.99793363
85MP0000462_abnormal_digestive_system0.99535139
86MP0000750_abnormal_muscle_regeneration0.99361598
87MP0003937_abnormal_limbs/digits/tail_de0.97898411
88MP0000858_altered_metastatic_potential0.97353729
89MP0002249_abnormal_larynx_morphology0.95566211
90MP0001243_abnormal_dermal_layer0.94203548
91MP0002092_abnormal_eye_morphology0.94193502
92MP0003935_abnormal_craniofacial_develop0.91987598
93MP0002089_abnormal_postnatal_growth/wei0.91781844
94MP0000778_abnormal_nervous_system0.91297256
95MP0002932_abnormal_joint_morphology0.91009433
96MP0005174_abnormal_tail_pigmentation0.89991856
97MP0002177_abnormal_outer_ear0.89506371
98MP0001614_abnormal_blood_vessel0.88934319
99MP0001175_abnormal_lung_morphology0.88388023
100MP0002233_abnormal_nose_morphology0.88281003
101* MP0002697_abnormal_eye_size0.88140393
102* MP0000049_abnormal_middle_ear0.87816887
103MP0001915_intracranial_hemorrhage0.87464521
104MP0003950_abnormal_plasma_membrane0.86674610
105MP0001790_abnormal_immune_system0.86301889
106MP0005387_immune_system_phenotype0.86301889
107MP0003329_amyloid_beta_deposits0.85494004
108MP0002295_abnormal_pulmonary_circulatio0.85260551
109MP0000343_altered_response_to0.84932076
110MP0002168_other_aberrant_phenotype0.84851330
111MP0004947_skin_inflammation0.84789154
112MP0002111_abnormal_tail_morphology0.84459929
113MP0001879_abnormal_lymphatic_vessel0.83941646
114MP0010368_abnormal_lymphatic_system0.83623013
115MP0002108_abnormal_muscle_morphology0.83233440
116MP0000516_abnormal_urinary_system0.82779036
117MP0005367_renal/urinary_system_phenotyp0.82779036
118MP0000467_abnormal_esophagus_morphology0.82607059
119MP0002925_abnormal_cardiovascular_devel0.81996893
120MP0000579_abnormal_nail_morphology0.80764739
121MP0003453_abnormal_keratinocyte_physiol0.78507506
122MP0005000_abnormal_immune_tolerance0.77629503
123MP0004808_abnormal_hematopoietic_stem0.77435467
124MP0005171_absent_coat_pigmentation0.75906269
125* MP0005193_abnormal_anterior_eye0.70171198
126MP0002128_abnormal_blood_circulation0.68705864
127MP0002085_abnormal_embryonic_tissue0.66331123
128MP0001177_atelectasis0.64335747
129MP0006138_congestive_heart_failure0.63892460
130MP0002796_impaired_skin_barrier0.63469312
131MP0000604_amyloidosis0.63176288
132* MP0002114_abnormal_axial_skeleton0.62211591
133MP0009672_abnormal_birth_weight0.62187245

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.01850754
2Protrusio acetabuli (HP:0003179)3.86646598
3Shallow orbits (HP:0000586)3.59654399
4Abnormality of dentin (HP:0010299)3.13231789
5Cerebral aneurysm (HP:0004944)3.08344153
6Vertebral compression fractures (HP:0002953)3.00468244
7Atrophic scars (HP:0001075)2.91415137
8Aortic dissection (HP:0002647)2.89899216
9Spinal rigidity (HP:0003306)2.78229773
10Short 4th metacarpal (HP:0010044)2.71236695
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71236695
12Peritonitis (HP:0002586)2.63416194
13Ankle contracture (HP:0006466)2.58260897
14Bladder diverticulum (HP:0000015)2.56908841
15Turricephaly (HP:0000262)2.54017748
16Hyperacusis (HP:0010780)2.50038108
17Aortic aneurysm (HP:0004942)2.45744446
18Abnormality of the nasal septum (HP:0000419)2.45472028
19Soft skin (HP:0000977)2.42388272
20Increased cerebral lipofuscin (HP:0011813)2.38645542
21Broad metatarsal (HP:0001783)2.38347873
22Eczematoid dermatitis (HP:0000976)2.36715775
23Dilatation of the ascending aorta (HP:0005111)2.35656730
24Natal tooth (HP:0000695)2.35496599
25Arterial tortuosity (HP:0005116)2.33383644
26Wide anterior fontanel (HP:0000260)2.32738759
27Mitral valve prolapse (HP:0001634)2.32463096
28Vascular tortuosity (HP:0004948)2.32373793
29Cervical subluxation (HP:0003308)2.30644862
30Hyperextensible skin (HP:0000974)2.30073474
31Recurrent abscess formation (HP:0002722)2.26506309
32Spinal cord lesions (HP:0100561)2.25840905
33Syringomyelia (HP:0003396)2.25840905
34Neurofibrillary tangles (HP:0002185)2.21783834
35Overgrowth (HP:0001548)2.20993187
36Absent frontal sinuses (HP:0002688)2.19042505
37Mitral regurgitation (HP:0001653)2.18803560
38Follicular hyperkeratosis (HP:0007502)2.13363560
39Disinhibition (HP:0000734)2.12508890
40Arnold-Chiari malformation (HP:0002308)2.09271387
41Biconcave vertebral bodies (HP:0004586)2.09257689
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.09061026
43Osteolytic defects of the hand bones (HP:0009699)2.09061026
44Prostate neoplasm (HP:0100787)2.08866941
45Ulnar bowing (HP:0003031)2.07827584
46Dysostosis multiplex (HP:0000943)2.05546341
47Spondylolisthesis (HP:0003302)2.05373633
48Narrow palate (HP:0000189)2.02726892
49Thick nail (HP:0001805)2.02447451
50Deviation of the hallux (HP:0010051)2.01889822
51Ectopia lentis (HP:0001083)2.01835259
52Nuclear cataract (HP:0100018)2.01311667
53Hypoventilation (HP:0002791)2.01204806
54Broad long bones (HP:0005622)2.00733662
55Tibial bowing (HP:0002982)1.98946151
56Abnormality of the 4th metacarpal (HP:0010012)1.98188887
57Neonatal short-limb short stature (HP:0008921)1.98107732
58Fragile skin (HP:0001030)1.97336369
59Coronal craniosynostosis (HP:0004440)1.97225158
60Tetraparesis (HP:0002273)1.95783525
61Asymmetry of the thorax (HP:0001555)1.95586536
62Increased variability in muscle fiber diameter (HP:0003557)1.95016867
63Midline defect of the nose (HP:0004122)1.94489362
64Blue sclerae (HP:0000592)1.91440699
65Abnormality of the parietal bone (HP:0002696)1.91048815
66Aortic regurgitation (HP:0001659)1.90098504
67Renovascular hypertension (HP:0100817)1.89993027
68Bone pain (HP:0002653)1.89985476
69Hallux valgus (HP:0001822)1.89230326
70Recurrent bacterial skin infections (HP:0005406)1.88949186
71Wormian bones (HP:0002645)1.87062453
72Abnormality of polysaccharide metabolism (HP:0011012)1.86655235
73Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86655235
74Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86655235
75Disproportionate tall stature (HP:0001519)1.85284440
76Increased neuronal autofluorescent lipopigment (HP:0002074)1.83479864
77Wrist flexion contracture (HP:0001239)1.82860318
78Renal duplication (HP:0000075)1.82816775
79Protruding ear (HP:0000411)1.81351941
80Overriding aorta (HP:0002623)1.80590899
81Urinary glycosaminoglycan excretion (HP:0003541)1.79171936
82Mucopolysacchariduria (HP:0008155)1.79171936
83Vertebral arch anomaly (HP:0008438)1.78963742
84Mildly elevated creatine phosphokinase (HP:0008180)1.77798858
85Camptodactyly of toe (HP:0001836)1.77612739
86Abnormality of the acetabulum (HP:0003170)1.77387128
87Broad ribs (HP:0000885)1.76622678
88Short nail (HP:0001799)1.76346004
89Cerebral inclusion bodies (HP:0100314)1.75978184
90Broad phalanx (HP:0006009)1.75942569
91Morphological abnormality of the middle ear (HP:0008609)1.75892004
92* Genu recurvatum (HP:0002816)1.75178679
93Joint laxity (HP:0001388)1.74278793
94Aplasia involving bones of the upper limbs (HP:0009823)1.73470054
95Aplasia of the phalanges of the hand (HP:0009802)1.73470054
96Aplasia involving bones of the extremities (HP:0009825)1.73470054
97Thin ribs (HP:0000883)1.73147741
98Bronchomalacia (HP:0002780)1.72875945
99Vitreoretinal degeneration (HP:0000655)1.71453854
100Upper limb amyotrophy (HP:0009129)1.70751750
101Distal upper limb amyotrophy (HP:0007149)1.70751750
102Slender build (HP:0001533)1.70403579
103Oligodontia (HP:0000677)1.70321411
104Broad face (HP:0000283)1.70197339
105Bowel diverticulosis (HP:0005222)1.69829275
106Hypoplasia of the iris (HP:0007676)1.69682141
107Aortic valve stenosis (HP:0001650)1.69047769
108Femoral bowing (HP:0002980)1.69016953
109Abnormality of the peritoneum (HP:0002585)1.68979169
110Mesomelia (HP:0003027)1.68899447
111Inguinal hernia (HP:0000023)1.68836118
112Broad finger (HP:0001500)1.68502577
113Aplasia cutis congenita (HP:0001057)1.68402207
114Increased density of long bones (HP:0006392)1.68057352
115Aneurysm (HP:0002617)1.67803712
116Elbow flexion contracture (HP:0002987)1.67666139
117Abnormality of the right ventricle (HP:0001707)1.66967683
118Persistence of primary teeth (HP:0006335)1.66865419
119Hypoplastic ischia (HP:0003175)1.66591367
120Pathologic fracture (HP:0002756)1.66471148
121Urethral obstruction (HP:0000796)1.66386335
122Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66002027
123Abnormality of the distal phalanx of the thumb (HP:0009617)1.65720795
124Mild short stature (HP:0003502)1.65287943
125Exostoses (HP:0100777)1.65024325
126Broad phalanges of the hand (HP:0009768)1.64989093
127Type 1 muscle fiber predominance (HP:0003803)1.64818369
128Subacute progressive viral hepatitis (HP:0006572)1.64608250
129Thin bony cortex (HP:0002753)1.63972346
130Advanced eruption of teeth (HP:0006288)1.63821807
131Abnormality of the frontal sinuses (HP:0002687)1.63713204
132Obstructive sleep apnea (HP:0002870)1.63576459
133Elfin facies (HP:0004428)1.63563920
134Craniofacial hyperostosis (HP:0004493)1.62543633
135Gingivitis (HP:0000230)1.62370647
136Insomnia (HP:0100785)1.62058360
137Choanal stenosis (HP:0000452)1.61977279
138Thoracolumbar scoliosis (HP:0002944)1.61667929
139Myocardial infarction (HP:0001658)1.61595732
140Abnormality of proline metabolism (HP:0010907)1.61537600
141Hydroxyprolinuria (HP:0003080)1.61537600
142Lymphangioma (HP:0100764)1.60870571
143Abnormality of glycolipid metabolism (HP:0010969)1.60227695
144Trigonocephaly (HP:0000243)1.59982824
145Pulmonary artery stenosis (HP:0004415)1.59584819
146Flat cornea (HP:0007720)1.59443420
147Uterine leiomyosarcoma (HP:0002891)1.59368285
148Leiomyosarcoma (HP:0100243)1.59368285
149Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.58947962
150Broad thumb (HP:0011304)1.58623702
151Abnormality of glycosphingolipid metabolism (HP:0004343)1.58025354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK13.20187913
2DDR23.04869582
3LATS12.93805350
4SIK12.73747926
5CDK122.64251760
6TRIB32.56311565
7EPHB22.43704943
8CAMK1D2.42930009
9TGFBR22.40619991
10BMX2.16848654
11TTN2.12793074
12CAMK1G2.01592389
13EEF2K2.00660525
14SIK22.00246964
15DMPK1.93537628
16PDGFRA1.92311200
17EPHA31.91324822
18EPHB11.91038103
19TYRO31.82246567
20RIPK11.77498099
21BLK1.71545130
22LATS21.68240797
23FGR1.60600652
24STK31.51985859
25RPS6KA41.49812903
26PKN21.47682871
27RIPK41.46984213
28TIE11.46716093
29PDGFRB1.44192307
30KIT1.41575077
31TBK11.39946085
32FGFR41.39751298
33CDK81.39323358
34MAP3K101.38090629
35PTK61.37107964
36PTK21.34907792
37IRAK31.31008684
38SMG11.30533896
39PAK41.28985803
40PRKD31.27709259
41ERN11.26969123
42JAK11.25284938
43NEK91.24097924
44SIK31.23306531
45MAP3K141.23303647
46PAK21.23291829
47CHUK1.21680131
48MYLK1.10178822
49PTK2B1.06994677
50LIMK11.06282619
51TESK11.05417979
52MARK11.05216417
53CSF1R1.04655908
54CDK61.02725922
55ERBB40.99609035
56MTOR0.96672828
57MARK30.94219230
58MET0.93926682
59LMTK20.92673047
60FER0.92487510
61ERBB20.91209875
62HCK0.90265862
63TGFBR10.90128272
64MAP3K30.89049732
65FGFR20.88717267
66EIF2AK20.87775271
67MAP3K60.87548226
68TYK20.83498511
69PRKD20.82806946
70TAOK10.82716535
71NUAK10.82616407
72STK100.81669432
73FGFR30.81649255
74PNCK0.80680708
75MOS0.80676268
76ERBB30.79939664
77RET0.79664612
78IKBKB0.78094697
79ROCK10.73433159
80EPHA20.71405501
81JAK30.71131955
82ABL10.69619935
83PRPF4B0.68979368
84FLT30.68343961
85PLK20.64340243
86FGFR10.63691232
87CSK0.62991210
88CASK0.62559509
89BMPR1B0.61374241
90STK38L0.60099113
91CLK10.59043036
92INSR0.58069810
93MAP3K90.57469093
94TNIK0.57315314
95* SRC0.57087536
96SCYL20.56778940
97RPS6KC10.56678326
98RPS6KL10.56678326
99MAPKAPK20.56417627
100KSR10.55999181
101PBK0.54854005
102MARK20.54367856
103TRPM70.54132874
104PRKG20.53155618
105ALK0.52819145
106EGFR0.51953114
107PAK60.51950427
108CDK150.51301280
109WNK10.51041791
110IGF1R0.49597370
111NTRK20.47797537
112CDK180.46917246
113CDK11A0.46444008
114ARAF0.45485135
115GSK3A0.44057392
116ILK0.43527823
117GRK70.43199763
118AKT20.42963139
119NME20.42778770
120FYN0.41466576
121STK240.41078215
122JAK20.40739612
123ABL20.40704628
124CDK90.40137866
125ICK0.39927022
126MKNK10.39559820
127YES10.39406612
128PRKCH0.39119624
129MAPK70.38849984
130MST1R0.38663405
131STK380.38448613
132LYN0.38361475
133BRD40.37740219
134CDC42BPA0.37329989
135TAOK20.36990677
136DYRK1B0.36629612
137RPS6KA20.36157782
138ROCK20.36030363
139MELK0.35513441
140MAPK100.35469697
141LRRK20.34538059
142KSR20.34318405
143MAP4K10.33684818
144TTK0.32820649
145CDK140.32566611
146AKT30.32371373
147PIM20.32248591
148RPS6KA60.32162723
149SGK30.30873506
150MAPK10.30298697
151PRKD10.29441277
152AKT10.28413283

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045121.82270332
2Glycosaminoglycan degradation_Homo sapiens_hsa005311.77971614
3Osteoclast differentiation_Homo sapiens_hsa043801.74458450
4Leishmaniasis_Homo sapiens_hsa051401.72418870
5Prion diseases_Homo sapiens_hsa050201.71549426
6Malaria_Homo sapiens_hsa051441.65830118
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60009327
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.59530364
9Chronic myeloid leukemia_Homo sapiens_hsa052201.57437132
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56653662
11Amoebiasis_Homo sapiens_hsa051461.55754727
12Small cell lung cancer_Homo sapiens_hsa052221.54828772
13Adherens junction_Homo sapiens_hsa045201.53819865
14Focal adhesion_Homo sapiens_hsa045101.53158488
15Proteoglycans in cancer_Homo sapiens_hsa052051.50902806
16Lysosome_Homo sapiens_hsa041421.49876969
17Pancreatic cancer_Homo sapiens_hsa052121.48625713
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.48559505
19Toxoplasmosis_Homo sapiens_hsa051451.44429774
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42673667
21Viral myocarditis_Homo sapiens_hsa054161.38432781
22TNF signaling pathway_Homo sapiens_hsa046681.38034408
23Tuberculosis_Homo sapiens_hsa051521.37367729
24MicroRNAs in cancer_Homo sapiens_hsa052061.34788919
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28187033
26Phagosome_Homo sapiens_hsa041451.23962724
27Tight junction_Homo sapiens_hsa045301.23772365
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.23358621
29Melanoma_Homo sapiens_hsa052181.22090574
30Basal cell carcinoma_Homo sapiens_hsa052171.18369311
31Melanogenesis_Homo sapiens_hsa049161.16034371
32Colorectal cancer_Homo sapiens_hsa052101.15679877
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.15514378
34Pertussis_Homo sapiens_hsa051331.14798756
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14210913
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12719870
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12634744
38Staphylococcus aureus infection_Homo sapiens_hsa051501.12512109
39Glioma_Homo sapiens_hsa052141.09707143
40Notch signaling pathway_Homo sapiens_hsa043301.09610782
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09431904
42Salmonella infection_Homo sapiens_hsa051321.09235573
43Axon guidance_Homo sapiens_hsa043601.07935136
44B cell receptor signaling pathway_Homo sapiens_hsa046621.06791780
45Gap junction_Homo sapiens_hsa045401.05474716
46Renal cell carcinoma_Homo sapiens_hsa052111.05100350
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04568394
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03444469
49Prostate cancer_Homo sapiens_hsa052151.01743508
50Rheumatoid arthritis_Homo sapiens_hsa053231.01058820
51Vibrio cholerae infection_Homo sapiens_hsa051101.00881521
52Hepatitis B_Homo sapiens_hsa051611.00644942
53Shigellosis_Homo sapiens_hsa051311.00407185
54TGF-beta signaling pathway_Homo sapiens_hsa043501.00023373
55Endometrial cancer_Homo sapiens_hsa052130.99630186
56Measles_Homo sapiens_hsa051620.99093563
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.98908933
58Hippo signaling pathway_Homo sapiens_hsa043900.98836658
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98543658
60Prolactin signaling pathway_Homo sapiens_hsa049170.98217911
61Apoptosis_Homo sapiens_hsa042100.97559267
62Thyroid cancer_Homo sapiens_hsa052160.96807378
63Influenza A_Homo sapiens_hsa051640.94863124
64Chemokine signaling pathway_Homo sapiens_hsa040620.93973294
65Estrogen signaling pathway_Homo sapiens_hsa049150.93477390
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92971838
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92806539
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.92552472
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.92244145
70Type II diabetes mellitus_Homo sapiens_hsa049300.91008850
71Other glycan degradation_Homo sapiens_hsa005110.90860871
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90618785
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90246677
74Dilated cardiomyopathy_Homo sapiens_hsa054140.89468137
75Pathways in cancer_Homo sapiens_hsa052000.88761464
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88514626
77Legionellosis_Homo sapiens_hsa051340.88142390
78Bladder cancer_Homo sapiens_hsa052190.87709021
79Platelet activation_Homo sapiens_hsa046110.87438021
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86597251
81Hedgehog signaling pathway_Homo sapiens_hsa043400.86570306
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85944783
83Acute myeloid leukemia_Homo sapiens_hsa052210.83820910
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82389940
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82331549
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80864772
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80759450
88Rap1 signaling pathway_Homo sapiens_hsa040150.80495633
89Dorso-ventral axis formation_Homo sapiens_hsa043200.80316104
90VEGF signaling pathway_Homo sapiens_hsa043700.79965308
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78175158
92Non-small cell lung cancer_Homo sapiens_hsa052230.77687605
93mTOR signaling pathway_Homo sapiens_hsa041500.76789364
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75744200
95Galactose metabolism_Homo sapiens_hsa000520.75104079
96HTLV-I infection_Homo sapiens_hsa051660.73989181
97HIF-1 signaling pathway_Homo sapiens_hsa040660.73118093
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73025594
99Protein digestion and absorption_Homo sapiens_hsa049740.71332444
100Herpes simplex infection_Homo sapiens_hsa051680.71034484
101Steroid biosynthesis_Homo sapiens_hsa001000.70067959
102GnRH signaling pathway_Homo sapiens_hsa049120.69668523
103Wnt signaling pathway_Homo sapiens_hsa043100.69408609
104ErbB signaling pathway_Homo sapiens_hsa040120.68090513
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.67261881
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66797781
107Hematopoietic cell lineage_Homo sapiens_hsa046400.65728783
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65696033
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65244352
110Ras signaling pathway_Homo sapiens_hsa040140.64411024
111Lysine degradation_Homo sapiens_hsa003100.64203610
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64193948
113Endocytosis_Homo sapiens_hsa041440.63426399
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62687733
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62679061
116Hepatitis C_Homo sapiens_hsa051600.62354778
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62190208
118Sphingolipid metabolism_Homo sapiens_hsa006000.59929267
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59509896
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58565621
121Complement and coagulation cascades_Homo sapiens_hsa046100.56811383
122Insulin signaling pathway_Homo sapiens_hsa049100.55490288
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55025221
124Mineral absorption_Homo sapiens_hsa049780.54905043
125Choline metabolism in cancer_Homo sapiens_hsa052310.49644184
126AMPK signaling pathway_Homo sapiens_hsa041520.48168777
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46495869
128MAPK signaling pathway_Homo sapiens_hsa040100.46320734
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45956510
130Thyroid hormone synthesis_Homo sapiens_hsa049180.44917894
131Vitamin B6 metabolism_Homo sapiens_hsa007500.40070553
132Ovarian steroidogenesis_Homo sapiens_hsa049130.39139052

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