SH3RF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1renal system development (GO:0072001)5.76767747
2cell adhesion mediated by integrin (GO:0033627)4.90484963
3negative regulation of keratinocyte proliferation (GO:0010839)4.10058376
4hemidesmosome assembly (GO:0031581)4.03262483
5limb bud formation (GO:0060174)3.82821461
6neuron cell-cell adhesion (GO:0007158)3.76269625
7cerebral cortex radially oriented cell migration (GO:0021799)3.53583555
8axonal fasciculation (GO:0007413)3.53564523
9postsynaptic membrane organization (GO:0001941)3.51042342
10negative regulation of axon guidance (GO:1902668)3.47982810
11auditory receptor cell differentiation (GO:0042491)3.46012960
12negative regulation of axon extension involved in axon guidance (GO:0048843)3.45680510
13chondrocyte proliferation (GO:0035988)3.29792510
14neuron recognition (GO:0008038)3.29508684
15central nervous system projection neuron axonogenesis (GO:0021952)3.23702917
16sequestering of extracellular ligand from receptor (GO:0035581)3.19128584
17branching involved in prostate gland morphogenesis (GO:0060442)3.05337445
18vocalization behavior (GO:0071625)3.05054909
19presynaptic membrane assembly (GO:0097105)3.04213007
20regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.99684017
21startle response (GO:0001964)2.99225078
22kidney morphogenesis (GO:0060993)2.93634787
23fibroblast migration (GO:0010761)2.91987018
24multicellular organismal aging (GO:0010259)2.91796259
25regulation of axon guidance (GO:1902667)2.89206594
26negative regulation of stem cell proliferation (GO:2000647)2.87134240
27lactate metabolic process (GO:0006089)2.83035784
28inner ear receptor cell differentiation (GO:0060113)2.82532826
29myoblast migration (GO:0051451)2.80091467
30regulation of axon extension involved in axon guidance (GO:0048841)2.79988386
31inner ear receptor cell development (GO:0060119)2.79428469
32adenosine metabolic process (GO:0046085)2.76705961
33negative regulation of oligodendrocyte differentiation (GO:0048715)2.75550574
34regulation of keratinocyte proliferation (GO:0010837)2.75469887
35axon extension involved in axon guidance (GO:0048846)2.73929491
36neuron projection extension involved in neuron projection guidance (GO:1902284)2.73929491
37lateral sprouting from an epithelium (GO:0060601)2.73346388
38nodal signaling pathway (GO:0038092)2.73129658
39glial cell proliferation (GO:0014009)2.71326190
40regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.69231726
41mitotic G1 DNA damage checkpoint (GO:0031571)2.68717486
42positive regulation of synapse assembly (GO:0051965)2.67996540
43positive regulation of protein autophosphorylation (GO:0031954)2.67552879
44glomerulus development (GO:0032835)2.66360051
45central nervous system neuron axonogenesis (GO:0021955)2.65584165
46presynaptic membrane organization (GO:0097090)2.65315568
47regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.65075413
48negative regulation of protein localization to cell surface (GO:2000009)2.64087928
49cell differentiation involved in kidney development (GO:0061005)2.64001037
50dendrite development (GO:0016358)2.63166924
51generation of neurons (GO:0048699)2.62907401
52apical protein localization (GO:0045176)2.61990614
53cell differentiation involved in metanephros development (GO:0072202)2.61869317
54ganglion development (GO:0061548)2.61316903
55mesenchymal cell differentiation involved in renal system development (GO:2001012)2.60500773
56mesenchymal cell differentiation involved in kidney development (GO:0072161)2.60500773
57dendritic spine morphogenesis (GO:0060997)2.59493146
58calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.59039658
59metanephric mesenchyme development (GO:0072075)2.58101090
60ephrin receptor signaling pathway (GO:0048013)2.58058452
61negative regulation of anoikis (GO:2000811)2.56998715
62regulation of integrin-mediated signaling pathway (GO:2001044)2.56323018
63facial nerve structural organization (GO:0021612)2.56279097
64female gonad development (GO:0008585)2.55759807
65regulation of synapse assembly (GO:0051963)2.55714758
66keratinocyte development (GO:0003334)2.54435690
67sympathetic nervous system development (GO:0048485)2.52700879
68righting reflex (GO:0060013)2.52314086
69regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.52240341
70smooth muscle tissue development (GO:0048745)2.51483541
71G1 DNA damage checkpoint (GO:0044783)2.49664129
72negative regulation of hormone biosynthetic process (GO:0032353)2.47849515
73negative regulation of hormone metabolic process (GO:0032351)2.47849515
74ionotropic glutamate receptor signaling pathway (GO:0035235)2.46799564
75cranial nerve structural organization (GO:0021604)2.45130725
76COPII vesicle coating (GO:0048208)2.44992168
77photoreceptor cell differentiation (GO:0046530)2.43847135
78eye photoreceptor cell differentiation (GO:0001754)2.43847135
79asymmetric protein localization (GO:0008105)2.42375723
80microtubule depolymerization (GO:0007019)2.42091901
81negative chemotaxis (GO:0050919)2.41538282
82serotonin receptor signaling pathway (GO:0007210)2.40293889
83axon extension (GO:0048675)2.39814300
84regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.39684001
85mitotic G1/S transition checkpoint (GO:0044819)2.39055570
86protein localization to synapse (GO:0035418)2.38999342
87UDP-N-acetylglucosamine metabolic process (GO:0006047)2.37689131
88negative regulation of axon extension (GO:0030517)2.36595633
89hair cell differentiation (GO:0035315)2.36110422
90regulation of hippo signaling (GO:0035330)2.35313779
91olfactory bulb development (GO:0021772)2.34722706
92establishment of planar polarity (GO:0001736)2.34236009
93establishment of tissue polarity (GO:0007164)2.34236009
94notochord development (GO:0030903)2.33708836
95mechanoreceptor differentiation (GO:0042490)2.33066324
96negative regulation of chondrocyte differentiation (GO:0032331)2.32630052
97retina vasculature morphogenesis in camera-type eye (GO:0061299)2.31275464
98prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.30620118
99hippo signaling (GO:0035329)2.27987113
100skin morphogenesis (GO:0043589)2.26963057
101cell migration in hindbrain (GO:0021535)2.26852566
102anatomical structure arrangement (GO:0048532)2.26788994
103kidney mesenchyme development (GO:0072074)2.26336255
104glutamate receptor signaling pathway (GO:0007215)2.24801177
105embryonic retina morphogenesis in camera-type eye (GO:0060059)2.24192350
106retinal ganglion cell axon guidance (GO:0031290)2.23585228
107collagen fibril organization (GO:0030199)2.22562094
108synaptic transmission, glutamatergic (GO:0035249)2.22355054
109neural crest cell development (GO:0014032)2.22047276
110dendritic spine organization (GO:0097061)2.21749140
111protein localization to microtubule (GO:0035372)2.21210757
112desmosome organization (GO:0002934)2.20875301
113mesenchymal-epithelial cell signaling (GO:0060638)2.20760680
114negative regulation of dendrite morphogenesis (GO:0050774)2.20718817
115anterior/posterior axis specification, embryo (GO:0008595)2.20578370
116cranial nerve morphogenesis (GO:0021602)2.19885611
117synapse assembly (GO:0007416)2.19144843
118negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.18272216
119activin receptor signaling pathway (GO:0032924)2.17333410
120retina layer formation (GO:0010842)2.17124118
121cell migration involved in sprouting angiogenesis (GO:0002042)2.16225496
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.15714012
123positive regulation of cardiac muscle cell differentiation (GO:2000727)2.15571751
124regulation of establishment of cell polarity (GO:2000114)2.14981317
125hindbrain development (GO:0030902)2.14472305
126regulation of double-strand break repair via homologous recombination (GO:0010569)2.14455639
127neuron migration (GO:0001764)2.12870099
128regulation of type B pancreatic cell apoptotic process (GO:2000674)2.12017848
129protein heterotrimerization (GO:0070208)2.11977234
130cerebral cortex cell migration (GO:0021795)2.11564640
131regulation of synapse organization (GO:0050807)2.10469669
132innervation (GO:0060384)2.09666417
133G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.09114596
134positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.08622900
135smoothened signaling pathway (GO:0007224)2.08088602
136endoplasmic reticulum organization (GO:0007029)2.07928871
137locomotory exploration behavior (GO:0035641)2.07915026
138embryonic foregut morphogenesis (GO:0048617)2.07862284
139negative regulation of dendrite development (GO:2000171)2.07475580
140positive regulation of cartilage development (GO:0061036)2.05655742
141regulation of glutamate receptor signaling pathway (GO:1900449)2.05598285
142membrane assembly (GO:0071709)2.05570166
143positive regulation of actin filament depolymerization (GO:0030836)2.05343776
144positive regulation of macroautophagy (GO:0016239)2.05004593
145neuron projection extension (GO:1990138)2.04880471
146pericardium development (GO:0060039)2.04063506
147spinal cord development (GO:0021510)2.03995656
148paraxial mesoderm development (GO:0048339)2.03288852
149negative regulation of myoblast differentiation (GO:0045662)2.03005760
150morphogenesis of an epithelial sheet (GO:0002011)2.02881880
151toxin metabolic process (GO:0009404)2.02582042
152layer formation in cerebral cortex (GO:0021819)2.02329323
153forebrain neuron differentiation (GO:0021879)2.02075321
154artery development (GO:0060840)2.01820354
155synaptic vesicle endocytosis (GO:0048488)2.01767212
156Leydig cell differentiation (GO:0033327)2.01611596
157camera-type eye morphogenesis (GO:0048593)2.01220915
158dentate gyrus development (GO:0021542)2.00939255
159regulation of timing of cell differentiation (GO:0048505)2.00898224
160extracellular regulation of signal transduction (GO:1900115)2.00112384
161extracellular negative regulation of signal transduction (GO:1900116)2.00112384
162regulation of protein glycosylation (GO:0060049)1.98627939
163cell-substrate junction assembly (GO:0007044)1.97143174
164regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.97035127
165dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.96270082
166positive regulation of neuroblast proliferation (GO:0002052)1.95555219
167lymphangiogenesis (GO:0001946)1.95298109
168glandular epithelial cell differentiation (GO:0002067)1.95164061
169regulation of chondrocyte differentiation (GO:0032330)1.94552448
170regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)1.94420156
171negative regulation of osteoblast proliferation (GO:0033689)1.94319183
172positive regulation of chondrocyte differentiation (GO:0032332)1.92977819
173mRNA cleavage (GO:0006379)1.92862542
174membrane budding (GO:0006900)1.92756104
175establishment or maintenance of monopolar cell polarity (GO:0061339)1.92629407
176establishment of monopolar cell polarity (GO:0061162)1.92629407
177negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)1.91770720
178positive regulation of pseudopodium assembly (GO:0031274)1.91600312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.71941085
2GBX2_23144817_ChIP-Seq_PC3_Human3.58027990
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.67117916
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66185747
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.44395598
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.28701429
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27728408
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27420307
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25327452
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.20828305
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18675929
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16414297
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.09315140
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.07234010
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.06770054
16AR_21909140_ChIP-Seq_LNCAP_Human2.06196569
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04292027
18IGF1R_20145208_ChIP-Seq_DFB_Human2.04179472
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.02915665
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02217264
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00977766
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00977766
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98115477
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94816742
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92269392
26* CBX2_27304074_Chip-Seq_ESCs_Mouse1.90040907
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87542825
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.85432018
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84891785
30* CJUN_26792858_Chip-Seq_BT549_Human1.84476512
31P300_19829295_ChIP-Seq_ESCs_Human1.82109338
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81664809
33TAF15_26573619_Chip-Seq_HEK293_Human1.81316122
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80907051
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80861467
36RNF2_27304074_Chip-Seq_NSC_Mouse1.79694229
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79291841
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73185710
39FUS_26573619_Chip-Seq_HEK293_Human1.72606544
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72494824
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.71484344
42* BRD4_25478319_ChIP-Seq_HGPS_Human1.69830210
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67298693
44AR_21572438_ChIP-Seq_LNCaP_Human1.66578349
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63802519
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61912211
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60997023
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.60661826
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.59711903
50FOXM1_26456572_ChIP-Seq_MCF-7_Human1.59444365
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58459095
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57156650
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.53857196
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.51379365
55TP53_18474530_ChIP-ChIP_U2OS_Human1.51021039
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50690080
57AHR_22903824_ChIP-Seq_MCF-7_Human1.50500179
58EWS_26573619_Chip-Seq_HEK293_Human1.50412876
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.49778361
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49710911
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48989435
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48989435
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48915237
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48645383
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.48089241
66TP53_16413492_ChIP-PET_HCT116_Human1.47253649
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46873059
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.44930211
69* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44916387
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43769739
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.43496083
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42718099
73VDR_22108803_ChIP-Seq_LS180_Human1.41038353
74* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40341272
75CDX2_20551321_ChIP-Seq_CACO-2_Human1.39785861
76* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39261191
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38393570
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.37686274
79* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37478347
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36793097
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35938028
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35868572
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34672406
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.34431872
85* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34046732
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33482103
87BCAT_22108803_ChIP-Seq_LS180_Human1.28886559
88* STAT3_23295773_ChIP-Seq_U87_Human1.28785497
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28062583
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27783936
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27718797
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26363938
93* FOXA1_25552417_ChIP-Seq_VCAP_Human1.25834677
94* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24907379
95* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24907379
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24878523
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24878523
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.24381635
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.23431753
100* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23329120
101* CDX2_22108803_ChIP-Seq_LS180_Human1.21023471
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.20402939
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18653585
104* TCF4_23295773_ChIP-Seq_U87_Human1.18194663
105SOX2_20726797_ChIP-Seq_SW620_Human1.17860177
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17601014
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.17354962
108* AR_25329375_ChIP-Seq_VCAP_Human1.17224542
109P53_22387025_ChIP-Seq_ESCs_Mouse1.17060830
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16602641
111ZNF274_21170338_ChIP-Seq_K562_Hela1.15614402
112RUNX2_22187159_ChIP-Seq_PCA_Human1.15177619
113WT1_19549856_ChIP-ChIP_CCG9911_Human1.14888455
114ER_23166858_ChIP-Seq_MCF-7_Human1.14612948
115TP63_19390658_ChIP-ChIP_HaCaT_Human1.14605518
116* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14216113
117JUN_21703547_ChIP-Seq_K562_Human1.13963933
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13756620
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13414595
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13022252
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.12696235
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12365643
123* ISL1_27105846_Chip-Seq_CPCs_Mouse1.12289974
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.12062949
125EP300_21415370_ChIP-Seq_HL-1_Mouse1.11179902
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10523852
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10197233
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10007218
129SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08706345
130NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08614116
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08155453
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06371129
133SMAD3_21741376_ChIP-Seq_HESCs_Human1.06315541
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04476566
135CBP_20019798_ChIP-Seq_JUKART_Human1.04476566
136TCF4_18268006_ChIP-ChIP_LS174T_Human1.03093241
137SOX2_21211035_ChIP-Seq_LN229_Gbm1.02927182
138HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02902413
139REST_21632747_ChIP-Seq_MESCs_Mouse1.02827706
140TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02698451
141KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02470764
142TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02331467
143TP63_23658742_ChIP-Seq_EP156T_Human1.00927340
144HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99962007
145* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99326815
146AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98975826
147* RXR_22108803_ChIP-Seq_LS180_Human0.96126494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.52070153
2MP0008438_abnormal_cutaneous_collagen2.86773916
3MP0003787_abnormal_imprinting2.80304275
4MP0004272_abnormal_basement_membrane2.74153846
5MP0001188_hyperpigmentation2.69589021
6MP0000778_abnormal_nervous_system2.65045503
7MP0000537_abnormal_urethra_morphology2.60595498
8MP0003880_abnormal_central_pattern2.38243368
9MP0004859_abnormal_synaptic_plasticity2.36469897
10MP0006292_abnormal_olfactory_placode2.29953133
11MP0010352_gastrointestinal_tract_polyps2.22503447
12MP0003941_abnormal_skin_development2.21175147
13MP0002102_abnormal_ear_morphology2.16801495
14MP0005171_absent_coat_pigmentation2.00257519
15MP0003283_abnormal_digestive_organ1.90308518
16MP0003385_abnormal_body_wall1.84024703
17MP0003950_abnormal_plasma_membrane1.76918438
18MP0010234_abnormal_vibrissa_follicle1.69672516
19MP0002735_abnormal_chemical_nociception1.69275820
20MP0003755_abnormal_palate_morphology1.68857977
21MP0003121_genomic_imprinting1.67797375
22MP0003937_abnormal_limbs/digits/tail_de1.67754889
23MP0002909_abnormal_adrenal_gland1.67145177
24MP0006054_spinal_hemorrhage1.65688417
25MP0001299_abnormal_eye_distance/1.64262703
26MP0004270_analgesia1.61305815
27MP0003705_abnormal_hypodermis_morpholog1.60405801
28MP0002063_abnormal_learning/memory/cond1.58697353
29MP0001177_atelectasis1.56328244
30MP0005275_abnormal_skin_tensile1.54650992
31MP0005248_abnormal_Harderian_gland1.52397672
32MP0009250_abnormal_appendicular_skeleto1.52374069
33MP0000049_abnormal_middle_ear1.51859393
34MP0008789_abnormal_olfactory_epithelium1.50315915
35MP0003938_abnormal_ear_development1.49415352
36MP0001529_abnormal_vocalization1.47288156
37MP0003635_abnormal_synaptic_transmissio1.47115766
38MP0002249_abnormal_larynx_morphology1.47071832
39MP0001958_emphysema1.43679052
40MP0000026_abnormal_inner_ear1.43058106
41MP0005499_abnormal_olfactory_system1.42947692
42MP0005394_taste/olfaction_phenotype1.42947692
43MP0004133_heterotaxia1.42321003
44MP0005646_abnormal_pituitary_gland1.40473785
45MP0002233_abnormal_nose_morphology1.39357635
46MP0002736_abnormal_nociception_after1.37678578
47MP0000762_abnormal_tongue_morphology1.37540618
48MP0003115_abnormal_respiratory_system1.35207438
49MP0003315_abnormal_perineum_morphology1.34852720
50MP0010678_abnormal_skin_adnexa1.34346313
51MP0002184_abnormal_innervation1.33388976
52MP0003122_maternal_imprinting1.32536357
53MP0000631_abnormal_neuroendocrine_gland1.32404965
54MP0002572_abnormal_emotion/affect_behav1.31443142
55MP0001486_abnormal_startle_reflex1.31014309
56MP0003890_abnormal_embryonic-extraembry1.30257903
57MP0002116_abnormal_craniofacial_bone1.30056696
58MP0000678_abnormal_parathyroid_gland1.29354671
59MP0003136_yellow_coat_color1.27891633
60MP0001968_abnormal_touch/_nociception1.27377467
61MP0003119_abnormal_digestive_system1.27221764
62MP0002557_abnormal_social/conspecific_i1.25994728
63MP0010386_abnormal_urinary_bladder1.25881094
64MP0009745_abnormal_behavioral_response1.24882177
65MP0006276_abnormal_autonomic_nervous1.22952387
66MP0010030_abnormal_orbit_morphology1.22815831
67MP0004742_abnormal_vestibular_system1.21076344
68MP0001485_abnormal_pinna_reflex1.21011036
69MP0010368_abnormal_lymphatic_system1.18202476
70MP0003861_abnormal_nervous_system1.17790138
71MP0000462_abnormal_digestive_system1.17042342
72MP0002734_abnormal_mechanical_nocicepti1.16579082
73MP0002653_abnormal_ependyma_morphology1.14277634
74MP0000534_abnormal_ureter_morphology1.14122106
75MP0005423_abnormal_somatic_nervous1.13833637
76MP0003566_abnormal_cell_adhesion1.13679456
77MP0002938_white_spotting1.13165297
78MP0002282_abnormal_trachea_morphology1.10412696
79MP0000013_abnormal_adipose_tissue1.10071687
80MP0004885_abnormal_endolymph1.09383389
81MP0000516_abnormal_urinary_system1.08867478
82MP0005367_renal/urinary_system_phenotyp1.08867478
83MP0002234_abnormal_pharynx_morphology1.08855148
84MP0003942_abnormal_urinary_system1.08737540
85MP0000579_abnormal_nail_morphology1.08169139
86MP0000432_abnormal_head_morphology1.08141118
87MP0005645_abnormal_hypothalamus_physiol1.07152350
88MP0003935_abnormal_craniofacial_develop1.06129996
89MP0000538_abnormal_urinary_bladder1.05954808
90MP0002177_abnormal_outer_ear1.03628131
91MP0002876_abnormal_thyroid_physiology1.02930215
92MP0009053_abnormal_anal_canal1.02867025
93MP0000647_abnormal_sebaceous_gland1.02066862
94MP0002751_abnormal_autonomic_nervous1.01069982
95MP0004134_abnormal_chest_morphology1.00050682
96MP0001286_abnormal_eye_development0.99494089
97MP0001963_abnormal_hearing_physiology0.99472366
98MP0002009_preneoplasia0.98969242
99MP0000767_abnormal_smooth_muscle0.98505037
100MP0001346_abnormal_lacrimal_gland0.98066193
101MP0002277_abnormal_respiratory_mucosa0.97213679
102MP0002896_abnormal_bone_mineralization0.96351061
103MP0009384_cardiac_valve_regurgitation0.95150082
104MP0000569_abnormal_digit_pigmentation0.95147420
105MP0000428_abnormal_craniofacial_morphol0.94144927
106MP0000955_abnormal_spinal_cord0.93834916
107MP0002111_abnormal_tail_morphology0.93545829
108MP0005508_abnormal_skeleton_morphology0.92688688
109MP0002882_abnormal_neuron_morphology0.92274252
110MP0000383_abnormal_hair_follicle0.91432563
111MP0002152_abnormal_brain_morphology0.90051762
112MP0005257_abnormal_intraocular_pressure0.89902292
113MP0004145_abnormal_muscle_electrophysio0.89790782
114MP0005503_abnormal_tendon_morphology0.88393733
115MP0002109_abnormal_limb_morphology0.87489302
116MP0005409_darkened_coat_color0.87309182
117MP0002697_abnormal_eye_size0.86920970
118MP0002084_abnormal_developmental_patter0.86902532
119MP0005623_abnormal_meninges_morphology0.86313828
120MP0008995_early_reproductive_senescence0.84851960
121MP0002064_seizures0.84119569
122MP0009780_abnormal_chondrocyte_physiolo0.83775565
123MP0008961_abnormal_basal_metabolism0.83394983
124MP0002752_abnormal_somatic_nervous0.82727190
125MP0003091_abnormal_cell_migration0.81503432
126MP0003868_abnormal_feces_composition0.80106939
127MP0002163_abnormal_gland_morphology0.80096670
128MP0001440_abnormal_grooming_behavior0.80091637
129MP0002067_abnormal_sensory_capabilities0.79578959
130MP0005187_abnormal_penis_morphology0.78866684
131MP0000733_abnormal_muscle_development0.78704224
132MP0004043_abnormal_pH_regulation0.77547220
133MP0000613_abnormal_salivary_gland0.77397727
134MP0000639_abnormal_adrenal_gland0.76521193
135MP0002108_abnormal_muscle_morphology0.76490113
136MP0002168_other_aberrant_phenotype0.75564998
137MP0005595_abnormal_vascular_smooth0.74047552
138MP0001944_abnormal_pancreas_morphology0.72171285
139MP0005023_abnormal_wound_healing0.72048897
140MP0001756_abnormal_urination0.69216348
141MP0003279_aneurysm0.69030903
142MP0001216_abnormal_epidermal_layer0.67006840
143MP0002060_abnormal_skin_morphology0.66722827
144MP0000427_abnormal_hair_cycle0.66679384
145MP0002295_abnormal_pulmonary_circulatio0.66277306
146MP0000163_abnormal_cartilage_morphology0.65509517

Predicted human phenotypes

RankGene SetZ-score
1Back pain (HP:0003418)5.09787882
2Papillary thyroid carcinoma (HP:0002895)3.25236965
3Cystic liver disease (HP:0006706)3.25201254
4Breech presentation (HP:0001623)3.15913921
5Abnormal hair whorl (HP:0010721)2.97703511
6Premature rupture of membranes (HP:0001788)2.84133319
7Abnormality of incisor morphology (HP:0011063)2.76346518
8Febrile seizures (HP:0002373)2.66873661
9Abnormality of the labia minora (HP:0012880)2.61062073
10Abnormality of the nasal septum (HP:0000419)2.60652991
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55722888
12Microglossia (HP:0000171)2.49943117
13Absent eyebrow (HP:0002223)2.48511076
14Focal motor seizures (HP:0011153)2.47885683
15Shawl scrotum (HP:0000049)2.47665301
16Gastrointestinal atresia (HP:0002589)2.47597189
17Breast hypoplasia (HP:0003187)2.47411007
18Pterygium (HP:0001059)2.42990429
19Intestinal atresia (HP:0011100)2.41476696
20Natal tooth (HP:0000695)2.41059303
21Neonatal short-limb short stature (HP:0008921)2.39569620
22Shallow orbits (HP:0000586)2.36090182
23Short nail (HP:0001799)2.32903679
24Cardiovascular calcification (HP:0011915)2.29230028
25Fragile skin (HP:0001030)2.28745839
26Abnormality of dentin (HP:0010299)2.25810714
27Morphological abnormality of the middle ear (HP:0008609)2.24486856
28Abnormality of the nasolacrimal system (HP:0000614)2.24394112
29Abnormality of the lacrimal duct (HP:0011481)2.21296916
30Aplasia cutis congenita (HP:0001057)2.20217799
31Abnormality of the aortic arch (HP:0012303)2.16200237
32Broad metatarsal (HP:0001783)2.14829511
33Bilateral sensorineural hearing impairment (HP:0008619)2.14794326
34Midline defect of the nose (HP:0004122)2.13686713
35Thyroid carcinoma (HP:0002890)2.13298043
36Chromsome breakage (HP:0040012)2.11363970
37Curly hair (HP:0002212)2.10610602
38Abnormality of the right ventricle (HP:0001707)2.07869971
39Occipital encephalocele (HP:0002085)2.05658613
40Abnormality of the labia (HP:0000058)2.03001182
41Fetal akinesia sequence (HP:0001989)2.02777122
42Nasolacrimal duct obstruction (HP:0000579)2.00282588
43Protrusio acetabuli (HP:0003179)1.99896722
44Anophthalmia (HP:0000528)1.98184372
45Thickened helices (HP:0000391)1.97254414
46Aplasia/Hypoplasia of the tongue (HP:0010295)1.97142542
47Tracheomalacia (HP:0002779)1.96578141
48Hyperventilation (HP:0002883)1.95330660
49Gastroesophageal reflux (HP:0002020)1.95099398
50Vascular calcification (HP:0004934)1.94568004
51Cupped ear (HP:0000378)1.94226511
52Aortic dissection (HP:0002647)1.88650835
53Abnormality of the distal phalanx of the thumb (HP:0009617)1.88391549
54Hemiparesis (HP:0001269)1.87852711
55Sleep apnea (HP:0010535)1.87680376
56Bronchomalacia (HP:0002780)1.87502113
57Epileptic encephalopathy (HP:0200134)1.87114504
58Obstructive sleep apnea (HP:0002870)1.86036096
59Aneurysm (HP:0002617)1.85568244
60Delayed gross motor development (HP:0002194)1.85378477
61Esophageal atresia (HP:0002032)1.84688102
62Coronal craniosynostosis (HP:0004440)1.84673223
63Limited hip movement (HP:0008800)1.84304877
64Protruding tongue (HP:0010808)1.83939950
65Vascular tortuosity (HP:0004948)1.83598938
66Broad-based gait (HP:0002136)1.82312480
67Septo-optic dysplasia (HP:0100842)1.81086994
68Follicular hyperkeratosis (HP:0007502)1.80919546
69Aplasia of the phalanges of the hand (HP:0009802)1.80725584
70Aplasia involving bones of the extremities (HP:0009825)1.80725584
71Aplasia involving bones of the upper limbs (HP:0009823)1.80725584
72Stomach cancer (HP:0012126)1.80406394
73Camptodactyly of toe (HP:0001836)1.79488610
74Prostate neoplasm (HP:0100787)1.79249359
75Progressive sensorineural hearing impairment (HP:0000408)1.78965456
76Asymmetry of the thorax (HP:0001555)1.78929136
77Ankle contracture (HP:0006466)1.78533385
78Oligodactyly (hands) (HP:0001180)1.78119697
79Renal hypoplasia (HP:0000089)1.77069353
80Facial hemangioma (HP:0000329)1.76986844
81Abnormality of chromosome segregation (HP:0002916)1.76066286
82Aortic aneurysm (HP:0004942)1.75944696
83Preaxial foot polydactyly (HP:0001841)1.75650750
84Patellar aplasia (HP:0006443)1.75580992
85Labial hypoplasia (HP:0000066)1.75540582
86Abnormality of the 1st metacarpal (HP:0010009)1.75336000
87Abnormality of the incisor (HP:0000676)1.75086189
88Cervical subluxation (HP:0003308)1.74253354
89Arterial tortuosity (HP:0005116)1.73605865
90Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.72522473
91Short 1st metacarpal (HP:0010034)1.72522473
92Excessive salivation (HP:0003781)1.72024410
93Drooling (HP:0002307)1.72024410
94Abnormality of molar (HP:0011077)1.71867186
95Abnormality of molar morphology (HP:0011070)1.71867186
96Soft skin (HP:0000977)1.71757290
97Capillary hemangiomas (HP:0005306)1.69552776
98Atonic seizures (HP:0010819)1.69480873
99Small hand (HP:0200055)1.69359516
100Scrotal hypoplasia (HP:0000046)1.67418884
101Pancreatic fibrosis (HP:0100732)1.66711921
102Lip pit (HP:0100267)1.66657667
103Bifid scrotum (HP:0000048)1.66519638
104Broad face (HP:0000283)1.66514892
105Testicular atrophy (HP:0000029)1.66485134
106Exotropia (HP:0000577)1.65817006
107Absent speech (HP:0001344)1.65217425
108Increased number of teeth (HP:0011069)1.65121642
109Hypoplastic female external genitalia (HP:0012815)1.65038509
110Cystic hygroma (HP:0000476)1.64371230
111Gonadotropin excess (HP:0000837)1.63893600
112Aplasia/Hypoplasia of the patella (HP:0006498)1.63655489
113Fair hair (HP:0002286)1.63350094
114Abnormal delivery (HP:0001787)1.62929229
115Birth length less than 3rd percentile (HP:0003561)1.62709006
116Anomalous pulmonary venous return (HP:0010772)1.61575091
117Aplasia/Hypoplasia of the sternum (HP:0006714)1.61315820
118Abnormality of permanent molar morphology (HP:0011071)1.60208830
119Abnormality of the dental root (HP:0006486)1.60208830
120Taurodontia (HP:0000679)1.60208830
121Generalized hypopigmentation of hair (HP:0011358)1.60036430
122Narrow nasal bridge (HP:0000446)1.60015172
123Onycholysis (HP:0001806)1.60012819
124Overgrowth (HP:0001548)1.59428871
125Volvulus (HP:0002580)1.58552586
126Abnormality of cochlea (HP:0000375)1.57838101
127Hypoplastic labia majora (HP:0000059)1.57476423
128Abnormality of salivation (HP:0100755)1.57331811
129Atrophic scars (HP:0001075)1.57093045
130Neonatal death (HP:0003811)1.56396461
131Cutaneous finger syndactyly (HP:0010554)1.56147041
132True hermaphroditism (HP:0010459)1.55991386
133Hypoplastic pelvis (HP:0008839)1.55507230
134Leiomyosarcoma (HP:0100243)1.55421499
135Uterine leiomyosarcoma (HP:0002891)1.55421499
136Tented upper lip vermilion (HP:0010804)1.55200406
137Synostosis of carpal bones (HP:0005048)1.54715231
138Popliteal pterygium (HP:0009756)1.54515745
139Progressive cerebellar ataxia (HP:0002073)1.54326660
140Transitional cell carcinoma of the bladder (HP:0006740)1.54066721
141Periauricular skin pits (HP:0100277)1.53800837
142Preauricular pit (HP:0004467)1.53800837
143Genital tract atresia (HP:0001827)1.53752236
144Milia (HP:0001056)1.52399596
145Cutaneous syndactyly (HP:0012725)1.52067774
146Short tibia (HP:0005736)1.51295108
147Abnormality of the axillary hair (HP:0100134)1.51278218
148Abnormality of secondary sexual hair (HP:0009888)1.51278218
149Advanced eruption of teeth (HP:0006288)1.50813455
150Atelectasis (HP:0100750)1.50574478
151Slender long bone (HP:0003100)1.50546909
152Aqueductal stenosis (HP:0002410)1.50501478
153Bifid tongue (HP:0010297)1.50455215
154Azoospermia (HP:0000027)1.49874099
155Abnormal biliary tract morphology (HP:0012440)1.49728790
156Pulmonic stenosis (HP:0001642)1.49115994
157Ectopic kidney (HP:0000086)1.49114185
158Abnormality of the labia majora (HP:0012881)1.48327193
159Wrist flexion contracture (HP:0001239)1.48286910
160Embryonal renal neoplasm (HP:0011794)1.48274025
161Congenital glaucoma (HP:0001087)1.47858776
162Abnormality of the pulmonary veins (HP:0011718)1.47459835
163Vaginal atresia (HP:0000148)1.47023195
164Hemivertebrae (HP:0002937)1.46962880
165Adrenal hypoplasia (HP:0000835)1.46955224
166Blue irides (HP:0000635)1.46754647
167Abnormality of the phalanges of the hallux (HP:0010057)1.46535735
168Abnormal lung lobation (HP:0002101)1.45882986
169Oligodactyly (HP:0012165)1.45854347
170Nephroblastoma (Wilms tumor) (HP:0002667)1.45432215
171Gait imbalance (HP:0002141)1.44157815
172Aplasia/Hypoplasia of the tibia (HP:0005772)1.43981174
173Astrocytoma (HP:0009592)1.43738331
174Abnormality of the astrocytes (HP:0100707)1.43738331
175Abnormality of the renal medulla (HP:0100957)1.43120872
176Cubitus valgus (HP:0002967)1.42698416
177Abnormality of the proximal phalanges of the hand (HP:0009834)1.42628088
178Bowel diverticulosis (HP:0005222)1.41791239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.21053926
2LATS13.23597478
3AKT32.70999183
4MET2.69126973
5TNIK2.52360358
6EPHB22.51622875
7MARK12.40334086
8CAMK1G2.32350711
9STK38L2.27923769
10CAMK1D2.27527754
11MKNK22.24697454
12PLK22.20247999
13MST1R2.17397355
14EPHA42.16677516
15LATS22.15593702
16MAP2K72.00656761
17BMPR1B2.00241668
18SIK31.83992465
19PRPF4B1.79922003
20SGK21.79724341
21BCR1.77877506
22MAPK131.70189490
23NUAK11.65801024
24NTRK31.64749243
25MAP4K21.64686284
26MYLK1.61560961
27PTK21.60355945
28SGK2231.56540590
29SGK4941.56540590
30ERBB31.53752023
31MKNK11.52011179
32KSR11.50474732
33EPHA21.43724525
34EPHA31.43530721
35TAOK21.41168979
36BMPR21.40805209
37MAP3K41.40568640
38NTRK21.38562214
39PNCK1.37064805
40OXSR11.33361881
41TAOK11.33182123
42NEK61.28886375
43FRK1.28880044
44TYRO31.27819139
45DMPK1.25414509
46ZAK1.23379429
47CDK81.20598107
48WNK41.19866003
49DYRK21.19657496
50PLK31.19466523
51MINK11.16400380
52MAP3K121.15764569
53PIM21.14941023
54CDK31.14057106
55SGK31.13025017
56PRKCI1.09725228
57ERBB41.09609293
58MST41.02272816
59YES11.01128988
60ACVR1B0.99252007
61RAF10.97357051
62PAK40.89734052
63FER0.88782925
64NEK90.85739248
65STK390.85278040
66EIF2AK30.83726286
67TRIM280.82954766
68MAP3K60.82021774
69NEK10.79104555
70PRKCE0.78898299
71DDR20.77235797
72PAK20.73735419
73ROCK10.71857268
74STK30.71198021
75SGK10.71061174
76GRK10.70374320
77CAMK2A0.68642665
78CAMK2D0.66794011
79ROCK20.66502866
80PRKG20.65705380
81STK240.65551737
82PBK0.65541592
83PHKG10.61631071
84PHKG20.61631071
85WNK30.60315603
86FGFR20.60130524
87CHEK20.59645097
88FGFR10.59023291
89NME10.58580585
90WEE10.58158971
91EIF2AK20.57133465
92DYRK1A0.56604350
93STK380.56128531
94PIK3CA0.55503728
95SRPK10.55485951
96CAMK2B0.55483970
97PRKD20.55330059
98CSNK1G10.54195329
99MTOR0.54006228
100CHUK0.52763028
101LMTK20.52190980
102DAPK20.52046229
103CSNK1A1L0.51913355
104DYRK30.51381305
105CSNK1G20.50825467
106PKN10.49709148
107BRD40.49393908
108MUSK0.49356348
109CAMK2G0.48448050
110TESK10.48438558
111PAK30.47253766
112PDGFRB0.46586285
113CDK50.46285790
114FLT30.46108966
115TXK0.45396623
116KSR20.44768463
117PRKCG0.44614039
118NTRK10.44032105
119PRKD30.42928839
120MELK0.42769942
121PKN20.42694169
122INSRR0.42541069
123TNK20.42404393
124TGFBR20.42015965
125PRKAA10.41370427
126PAK60.39860694
127GSK3A0.39675767
128NLK0.37278655
129SIK20.36533288
130MAP2K10.35691001
131CSNK1G30.35560810
132BRSK10.35390001
133IRAK20.34604442
134IRAK10.34326792
135PTK2B0.32219156
136MAP2K60.32048311
137LIMK10.31445579
138FGR0.30522061
139ATM0.30162132
140MARK20.29736701
141BRSK20.29580396
142TRPM70.28981974
143PDGFRA0.28727334
144GSK3B0.27655364
145PLK40.26567233

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.70421010
2Nicotine addiction_Homo sapiens_hsa050332.47763979
3Axon guidance_Homo sapiens_hsa043602.22792952
4Basal cell carcinoma_Homo sapiens_hsa052171.88515929
5Homologous recombination_Homo sapiens_hsa034401.72144851
6Hippo signaling pathway_Homo sapiens_hsa043901.70837302
7Propanoate metabolism_Homo sapiens_hsa006401.63083434
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60707197
9Wnt signaling pathway_Homo sapiens_hsa043101.56140383
10Glutamatergic synapse_Homo sapiens_hsa047241.54684580
11Endometrial cancer_Homo sapiens_hsa052131.53669436
12Adherens junction_Homo sapiens_hsa045201.50227929
13Steroid biosynthesis_Homo sapiens_hsa001001.45362135
14Long-term potentiation_Homo sapiens_hsa047201.44498076
15Sulfur metabolism_Homo sapiens_hsa009201.43943823
16Serotonergic synapse_Homo sapiens_hsa047261.43751323
17Fatty acid biosynthesis_Homo sapiens_hsa000611.42739848
18TGF-beta signaling pathway_Homo sapiens_hsa043501.42292358
19Melanogenesis_Homo sapiens_hsa049161.40041541
20Mismatch repair_Homo sapiens_hsa034301.39933726
21Circadian entrainment_Homo sapiens_hsa047131.39246620
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33821409
23MicroRNAs in cancer_Homo sapiens_hsa052061.33599278
24Amphetamine addiction_Homo sapiens_hsa050311.33184275
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32994023
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32701215
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32647825
28Taste transduction_Homo sapiens_hsa047421.32564341
29Hedgehog signaling pathway_Homo sapiens_hsa043401.29730691
30ErbB signaling pathway_Homo sapiens_hsa040121.28472413
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.27786025
32Morphine addiction_Homo sapiens_hsa050321.27478526
33Non-homologous end-joining_Homo sapiens_hsa034501.27316823
34Protein digestion and absorption_Homo sapiens_hsa049741.26859050
35Long-term depression_Homo sapiens_hsa047301.26361998
36Thyroid hormone synthesis_Homo sapiens_hsa049181.25668115
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21736993
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18806733
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17968516
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.17658863
41Cholinergic synapse_Homo sapiens_hsa047251.15816368
42Colorectal cancer_Homo sapiens_hsa052101.13894084
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13300563
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11173782
45GnRH signaling pathway_Homo sapiens_hsa049121.10606509
46Synaptic vesicle cycle_Homo sapiens_hsa047211.09851064
47Dopaminergic synapse_Homo sapiens_hsa047281.09511833
48Melanoma_Homo sapiens_hsa052181.09174673
49GABAergic synapse_Homo sapiens_hsa047271.07178280
50Glioma_Homo sapiens_hsa052141.06641097
51Olfactory transduction_Homo sapiens_hsa047401.05970981
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05388205
53Tight junction_Homo sapiens_hsa045301.04093457
54Caffeine metabolism_Homo sapiens_hsa002321.03941251
55Gap junction_Homo sapiens_hsa045401.03275384
56Cocaine addiction_Homo sapiens_hsa050301.01493735
57Choline metabolism in cancer_Homo sapiens_hsa052311.01401422
58Renal cell carcinoma_Homo sapiens_hsa052111.01073326
59ECM-receptor interaction_Homo sapiens_hsa045120.99592356
60Prostate cancer_Homo sapiens_hsa052150.99019312
61Ras signaling pathway_Homo sapiens_hsa040140.96082890
62Rap1 signaling pathway_Homo sapiens_hsa040150.95764103
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95277498
64Basal transcription factors_Homo sapiens_hsa030220.95149700
65Salivary secretion_Homo sapiens_hsa049700.95129176
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95004663
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93171397
68Pyruvate metabolism_Homo sapiens_hsa006200.93133285
69Pancreatic secretion_Homo sapiens_hsa049720.92681083
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90868118
71Vitamin B6 metabolism_Homo sapiens_hsa007500.90068357
72Notch signaling pathway_Homo sapiens_hsa043300.89618965
73Focal adhesion_Homo sapiens_hsa045100.88821001
74Selenocompound metabolism_Homo sapiens_hsa004500.88485337
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88155351
76Renin-angiotensin system_Homo sapiens_hsa046140.86268169
77Nucleotide excision repair_Homo sapiens_hsa034200.85634015
78Oxytocin signaling pathway_Homo sapiens_hsa049210.83772284
79Gastric acid secretion_Homo sapiens_hsa049710.83625772
80Autoimmune thyroid disease_Homo sapiens_hsa053200.83575387
81MAPK signaling pathway_Homo sapiens_hsa040100.83403472
82Folate biosynthesis_Homo sapiens_hsa007900.82535989
83Lysine degradation_Homo sapiens_hsa003100.82529590
84Collecting duct acid secretion_Homo sapiens_hsa049660.82482414
85cAMP signaling pathway_Homo sapiens_hsa040240.82450811
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81996742
87Pathways in cancer_Homo sapiens_hsa052000.81652051
88Histidine metabolism_Homo sapiens_hsa003400.81455810
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80371934
90Pancreatic cancer_Homo sapiens_hsa052120.80359518
91Ovarian steroidogenesis_Homo sapiens_hsa049130.79948863
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79210611
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78169730
94Vibrio cholerae infection_Homo sapiens_hsa051100.78080702
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77461484
96Insulin secretion_Homo sapiens_hsa049110.75801451
97Arginine and proline metabolism_Homo sapiens_hsa003300.75772052
98FoxO signaling pathway_Homo sapiens_hsa040680.75110050
99Cell cycle_Homo sapiens_hsa041100.74690505
100Renin secretion_Homo sapiens_hsa049240.74571930
101Glucagon signaling pathway_Homo sapiens_hsa049220.74370831
102Dorso-ventral axis formation_Homo sapiens_hsa043200.74311687
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74287192
104Fanconi anemia pathway_Homo sapiens_hsa034600.74268584
105Proteoglycans in cancer_Homo sapiens_hsa052050.74162843
106Circadian rhythm_Homo sapiens_hsa047100.73677753
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73554397
108Thyroid cancer_Homo sapiens_hsa052160.73492119
109Dilated cardiomyopathy_Homo sapiens_hsa054140.71764011
110Estrogen signaling pathway_Homo sapiens_hsa049150.70775927
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70421006
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69867782
113Ether lipid metabolism_Homo sapiens_hsa005650.69632299
114Prolactin signaling pathway_Homo sapiens_hsa049170.69389469
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68691157
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68629400
117Calcium signaling pathway_Homo sapiens_hsa040200.67684485
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.67614605
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67536526
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66642011
121Small cell lung cancer_Homo sapiens_hsa052220.65605495
122Oocyte meiosis_Homo sapiens_hsa041140.64257636
123Fat digestion and absorption_Homo sapiens_hsa049750.64056948
124mRNA surveillance pathway_Homo sapiens_hsa030150.63011712
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62705463
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62564655
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61885431
128Rheumatoid arthritis_Homo sapiens_hsa053230.61678455
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61301890
130Sphingolipid metabolism_Homo sapiens_hsa006000.60419742
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60207720
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.60003583
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59832494
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59238651
135Non-small cell lung cancer_Homo sapiens_hsa052230.57609507
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.56860593
137Mineral absorption_Homo sapiens_hsa049780.56280596
138Retinol metabolism_Homo sapiens_hsa008300.55860403
139Glutathione metabolism_Homo sapiens_hsa004800.55028228
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.54876560
141Bladder cancer_Homo sapiens_hsa052190.54050872
142Arginine biosynthesis_Homo sapiens_hsa002200.53956813
143Bile secretion_Homo sapiens_hsa049760.53856864
144Fatty acid metabolism_Homo sapiens_hsa012120.52453364
145N-Glycan biosynthesis_Homo sapiens_hsa005100.52374377
146Chemical carcinogenesis_Homo sapiens_hsa052040.50042809
147Primary bile acid biosynthesis_Homo sapiens_hsa001200.47989341

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