SH3RF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.58084784
2carnitine shuttle (GO:0006853)6.84922019
3carnitine transmembrane transport (GO:1902603)6.12646476
4amino-acid betaine transport (GO:0015838)5.76627276
5carnitine transport (GO:0015879)5.76627276
6fatty acid transmembrane transport (GO:1902001)5.60336770
7sperm motility (GO:0030317)5.48601097
8rRNA catabolic process (GO:0016075)5.44833830
9cell wall macromolecule metabolic process (GO:0044036)5.40161313
10cell wall macromolecule catabolic process (GO:0016998)5.40161313
11sarcomere organization (GO:0045214)5.36523732
12bundle of His cell to Purkinje myocyte communication (GO:0086069)5.20867408
13hemidesmosome assembly (GO:0031581)5.19630831
14acrosome reaction (GO:0007340)5.08487961
15plasma membrane repair (GO:0001778)4.90341252
16fusion of sperm to egg plasma membrane (GO:0007342)4.88310468
17negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.74079117
18fatty acid homeostasis (GO:0055089)4.72280183
19regulation of cardioblast differentiation (GO:0051890)4.66642152
20regulation of skeletal muscle contraction (GO:0014819)4.65846498
21actin-myosin filament sliding (GO:0033275)4.62078452
22muscle filament sliding (GO:0030049)4.62078452
23gap junction assembly (GO:0016264)4.59419880
24NADH metabolic process (GO:0006734)4.54065749
25ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.33104264
26regulation of the force of heart contraction (GO:0002026)4.32333598
27multicellular organism reproduction (GO:0032504)4.30333201
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.27265724
29cardiac myofibril assembly (GO:0055003)4.23886261
30cardiac muscle hypertrophy (GO:0003300)4.16980931
31myofibril assembly (GO:0030239)4.16551553
32acrosome assembly (GO:0001675)4.16185620
33positive regulation of glycolytic process (GO:0045821)4.11040707
34negative regulation of inclusion body assembly (GO:0090084)4.09157961
35negative regulation of potassium ion transmembrane transport (GO:1901380)4.08644537
36sperm-egg recognition (GO:0035036)4.03413400
37quaternary ammonium group transport (GO:0015697)4.00814052
38ventricular cardiac muscle cell action potential (GO:0086005)3.98584048
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.97748490
40striated muscle hypertrophy (GO:0014897)3.92265986
41actin-mediated cell contraction (GO:0070252)3.85396102
42plasma membrane fusion (GO:0045026)3.83943366
43sarcoplasmic reticulum calcium ion transport (GO:0070296)3.81356882
44cell communication by electrical coupling (GO:0010644)3.78175638
45reproduction (GO:0000003)3.76783117
46regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.74453330
47cell communication involved in cardiac conduction (GO:0086065)3.71882375
48cardiac muscle contraction (GO:0060048)3.70557660
49cell-cell recognition (GO:0009988)3.63950488
50regulation of energy homeostasis (GO:2000505)3.63667681
51regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.62205669
52adult heart development (GO:0007512)3.61683690
53binding of sperm to zona pellucida (GO:0007339)3.52260513
54establishment of skin barrier (GO:0061436)3.47786540
55sperm capacitation (GO:0048240)3.47679817
56keratinization (GO:0031424)3.46561332
57striated muscle contraction (GO:0006941)3.46024889
58actomyosin structure organization (GO:0031032)3.44794894
59regulation of synapse structural plasticity (GO:0051823)3.44273768
60regulation of water loss via skin (GO:0033561)3.41184917
61regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.40938707
62phosphatidylinositol acyl-chain remodeling (GO:0036149)3.39454290
63response to inactivity (GO:0014854)3.37715341
64atrioventricular valve morphogenesis (GO:0003181)3.36292158
65positive regulation of prostaglandin secretion (GO:0032308)3.36216221
66muscle hypertrophy (GO:0014896)3.36196834
67water homeostasis (GO:0030104)3.35823899
68motile cilium assembly (GO:0044458)3.30312319
69regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.26239463
70regulation of cardiac muscle cell contraction (GO:0086004)3.25948286
71spermatid development (GO:0007286)3.23526682
72epithelial cell-cell adhesion (GO:0090136)3.22439521
73regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.21805194
74regulation of striated muscle contraction (GO:0006942)3.21733418
75cardiac muscle cell development (GO:0055013)3.20346132
76intracellular lipid transport (GO:0032365)3.20046786
77cardiac conduction (GO:0061337)3.18979869
78regulation of tight junction assembly (GO:2000810)3.17369816
79regulation of heart rate by cardiac conduction (GO:0086091)3.15320193
80cardiac muscle cell action potential involved in contraction (GO:0086002)3.14637520
81phosphatidylserine acyl-chain remodeling (GO:0036150)3.14174722
82regulation of membrane repolarization (GO:0060306)3.13746477
83creatine metabolic process (GO:0006600)3.12668660
84axonemal dynein complex assembly (GO:0070286)3.10569997
85tricarboxylic acid cycle (GO:0006099)3.09516155
86regulation of inclusion body assembly (GO:0090083)3.08802234
87cardiac muscle cell action potential (GO:0086001)3.08467571
88cardiac cell development (GO:0055006)3.08113404
89skeletal muscle contraction (GO:0003009)3.05677752
90epithelial cilium movement (GO:0003351)2.98671853
91regulation of cilium movement (GO:0003352)2.98457185
92heart contraction (GO:0060047)2.97080652
93heart process (GO:0003015)2.97080652
94keratinocyte proliferation (GO:0043616)2.96652516
95actin filament-based movement (GO:0030048)2.96433658
96negative regulation of protein localization to cell surface (GO:2000009)2.93072656
97phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.91555837
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91418137
99regulation of actin filament-based movement (GO:1903115)2.89939724
100peptide cross-linking (GO:0018149)2.88809832
101negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88748776
102cell-substrate junction assembly (GO:0007044)2.88514200
103positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.87640203
104regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.87318900
105positive regulation of icosanoid secretion (GO:0032305)2.87080720
106regulation of heart contraction (GO:0008016)2.86706985
107histone-serine phosphorylation (GO:0035404)2.85860831
108intermediate filament organization (GO:0045109)2.85258284
109chromosome condensation (GO:0030261)2.85234369
110regulation of relaxation of muscle (GO:1901077)2.81165959
111regulation of cell communication by electrical coupling (GO:0010649)2.80987281
112relaxation of cardiac muscle (GO:0055119)2.79171939
113actin filament depolymerization (GO:0030042)2.76981663
114detection of calcium ion (GO:0005513)2.76459111
115regulation of protein localization to cell surface (GO:2000008)2.74355863
116single fertilization (GO:0007338)2.73465701
117mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.72307572
118phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.71862460
119response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.71675782
120cardiac muscle tissue morphogenesis (GO:0055008)2.71343936
121epidermal cell differentiation (GO:0009913)2.70192878
122cardiac muscle hypertrophy in response to stress (GO:0014898)2.69971743
123muscle hypertrophy in response to stress (GO:0003299)2.69971743
124cardiac muscle adaptation (GO:0014887)2.69971743
125regulation of ATP catabolic process (GO:1903289)2.69573203
126regulation of ATPase activity (GO:0043462)2.69573203
127regulation of prostaglandin secretion (GO:0032306)2.69013402
128regulation of cardiac muscle contraction (GO:0055117)2.65997994
129positive regulation of heart rate (GO:0010460)2.65935950
130response to muscle activity (GO:0014850)2.63925535
131negative regulation of potassium ion transport (GO:0043267)2.62384706
132muscle system process (GO:0003012)2.61689174
133organic cation transport (GO:0015695)2.61158610
134negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.60137519
135keratinocyte differentiation (GO:0030216)2.59873776
136regulation of transforming growth factor beta2 production (GO:0032909)2.59003543
137regulation of heart rate (GO:0002027)2.58861413
138regulation of cholesterol homeostasis (GO:2000188)2.58043046
139positive regulation of action potential (GO:0045760)2.57820033
140muscle tissue morphogenesis (GO:0060415)2.57320999
141epidermis development (GO:0008544)2.56965285
142calcium ion-dependent exocytosis (GO:0017156)2.56743282
143multicellular organismal water homeostasis (GO:0050891)2.56474129
144positive regulation of lipid storage (GO:0010884)2.54936195
145muscle contraction (GO:0006936)2.53386735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.43932236
2EZH2_22144423_ChIP-Seq_EOC_Human2.81382768
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.52448649
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.45754911
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22933040
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.97346003
7* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.93646126
8* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.93646126
9EP300_21415370_ChIP-Seq_HL-1_Mouse1.89408935
10RXR_22158963_ChIP-Seq_LIVER_Mouse1.82566926
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82193111
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.79657995
13PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76227391
14CDX2_20551321_ChIP-Seq_CACO-2_Human1.75416446
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74970518
16HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67252656
17* LXR_22158963_ChIP-Seq_LIVER_Mouse1.67067688
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65259673
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63551778
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63392727
21* GATA4_25053715_ChIP-Seq_YYC3_Human1.61637786
22TBX20_22328084_ChIP-Seq_HEART_Mouse1.60048052
23TBX20_22080862_ChIP-Seq_HEART_Mouse1.60048052
24ZNF263_19887448_ChIP-Seq_K562_Human1.57271525
25* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56128726
26SOX2_20726797_ChIP-Seq_SW620_Human1.48762673
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.48512122
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47203019
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46438325
30P63_26484246_Chip-Seq_KERATINOCYTES_Human1.45157083
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44740148
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42795184
33CTCF_27219007_Chip-Seq_Bcells_Human1.42400509
34* GATA6_25053715_ChIP-Seq_YYC3_Human1.41899495
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.41001814
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.36636736
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36088639
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34419711
39CLOCK_20551151_ChIP-Seq_293T_Human1.34415241
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.33477337
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31743831
42MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.31418631
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30643239
44* TP63_22573176_ChIP-Seq_HFKS_Human1.29038845
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.27831024
46VDR_22108803_ChIP-Seq_LS180_Human1.27517842
47TP53_18474530_ChIP-ChIP_U2OS_Human1.26766193
48* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26617344
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.26169742
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24332037
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24279183
52DROSHA_22980978_ChIP-Seq_HELA_Human1.23673214
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18414683
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18087745
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17933413
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16282000
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15514997
58NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12549742
59* GATA3_24758297_ChIP-Seq_MCF-7_Human1.11677993
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11125530
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.10712099
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.10383264
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.09927013
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09876919
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.09755780
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08894894
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08351087
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06276837
69* ATF3_27146783_Chip-Seq_COLON_Human1.05839158
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05240112
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04991248
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04509609
73* CJUN_26792858_Chip-Seq_BT549_Human1.04332819
74* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03609391
75SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00904924
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00162037
77RNF2_27304074_Chip-Seq_ESCs_Mouse0.99755543
78SMAD3_21741376_ChIP-Seq_HESCs_Human0.98667747
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98620126
80FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98527421
81* AHR_22903824_ChIP-Seq_MCF-7_Human0.97916646
82EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96996057
83RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96996057
84RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96330873
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94435767
86JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92417178
87RXR_22108803_ChIP-Seq_LS180_Human0.92271510
88* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91997780
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90846617
90MYC_27129775_Chip-Seq_CORNEA_Mouse0.90609679
91KLF5_25053715_ChIP-Seq_YYC3_Human0.90465744
92* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89898026
93* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88989620
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88728348
95LXR_22292898_ChIP-Seq_THP-1_Human0.88451484
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87988812
97UBF1/2_26484160_Chip-Seq_HMECs_Human0.87632442
98BCOR_27268052_Chip-Seq_Bcells_Human0.86916150
99RACK7_27058665_Chip-Seq_MCF-7_Human0.86627990
100SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86506736
101* CDX2_22108803_ChIP-Seq_LS180_Human0.86467755
102BCAT_22108803_ChIP-Seq_LS180_Human0.85786779
103SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85218392
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84931638
105BP1_19119308_ChIP-ChIP_Hs578T_Human0.84712813
106CTCF_20526341_ChIP-Seq_ESCs_Human0.84655833
107SA1_27219007_Chip-Seq_Bcells_Human0.84544704
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84431682
109OCT1_27270436_Chip-Seq_PROSTATE_Human0.84030693
110WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83919604
111PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82534824
112CBX2_27304074_Chip-Seq_ESCs_Mouse0.82320767
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81769274
114OCT4_20526341_ChIP-Seq_ESCs_Human0.81703749
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81160993
116NANOG_20526341_ChIP-Seq_ESCs_Human0.81121817
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80585092
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80288561
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80193176
120CSB_26484114_Chip-Seq_FIBROBLAST_Human0.79929004
121TP63_23658742_ChIP-Seq_EP156T_Human0.79544844
122HNFA_21074721_ChIP-Seq_CACO-2_Human0.79378359
123NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78369146
124CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.78077306
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77993545
126BCL6_27268052_Chip-Seq_Bcells_Human0.77824451
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.77561629
128SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77551748
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.76447386
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76346029
131* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76020966
132GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.75717548
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75708453
134FOXH1_21741376_ChIP-Seq_ESCs_Human0.74898260
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74217842
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74153323
137SMC4_20622854_ChIP-Seq_HELA_Human0.73850202
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.73842329
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.73761681
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73676296
141* ARNT_22903824_ChIP-Seq_MCF-7_Human0.73531158
142* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73172194
143FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72942260
144PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.72921532
145TP53_20018659_ChIP-ChIP_R1E_Mouse0.72649670
146RING1B_27294783_Chip-Seq_ESCs_Mouse0.72171997
147TP53_16413492_ChIP-PET_HCT116_Human0.72096013
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71951167
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71580911

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.09040867
2MP0005410_abnormal_fertilization4.59051217
3MP0000751_myopathy4.09546895
4MP0002837_dystrophic_cardiac_calcinosis4.01581947
5MP0002822_catalepsy4.01493267
6MP0002796_impaired_skin_barrier3.79403824
7MP0004084_abnormal_cardiac_muscle3.08766914
8MP0004130_abnormal_muscle_cell3.02115778
9MP0004036_abnormal_muscle_relaxation2.96986995
10MP0002909_abnormal_adrenal_gland2.88305154
11MP0000749_muscle_degeneration2.87484968
12MP0010234_abnormal_vibrissa_follicle2.68183620
13MP0005275_abnormal_skin_tensile2.66031758
14MP0004215_abnormal_myocardial_fiber2.65810553
15MP0003941_abnormal_skin_development2.50413317
16MP0005451_abnormal_body_composition2.35056095
17MP0004484_altered_response_of2.34207466
18MP0004087_abnormal_muscle_fiber2.17014558
19MP0005330_cardiomyopathy2.16002662
20MP0004145_abnormal_muscle_electrophysio2.14103383
21MP0002972_abnormal_cardiac_muscle1.99374011
22MP0002234_abnormal_pharynx_morphology1.96076707
23MP0005620_abnormal_muscle_contractility1.93600434
24MP0005501_abnormal_skin_physiology1.89873074
25MP0000579_abnormal_nail_morphology1.89212857
26MP0002106_abnormal_muscle_physiology1.85604236
27MP0000750_abnormal_muscle_regeneration1.78519901
28MP0005360_urolithiasis1.74553453
29MP0004233_abnormal_muscle_weight1.70016244
30MP0002254_reproductive_system_inflammat1.60695070
31MP0005385_cardiovascular_system_phenoty1.60512806
32MP0001544_abnormal_cardiovascular_syste1.60512806
33MP0003137_abnormal_impulse_conducting1.60480432
34MP0002269_muscular_atrophy1.60303751
35MP0002060_abnormal_skin_morphology1.58587359
36MP0000566_synostosis1.58296445
37MP0000759_abnormal_skeletal_muscle1.56269541
38MP0005369_muscle_phenotype1.51013764
39MP0005187_abnormal_penis_morphology1.48921012
40MP0003705_abnormal_hypodermis_morpholog1.48724010
41MP0000383_abnormal_hair_follicle1.47711310
42MP0000537_abnormal_urethra_morphology1.43751125
43MP0004264_abnormal_extraembryonic_tissu1.41318922
44MP0009379_abnormal_foot_pigmentation1.41123095
45MP0010678_abnormal_skin_adnexa1.38985257
46MP0004272_abnormal_basement_membrane1.37618907
47MP0001216_abnormal_epidermal_layer1.37201308
48MP0003698_abnormal_male_reproductive1.35544781
49MP0010771_integument_phenotype1.34698973
50MP0006138_congestive_heart_failure1.33011769
51MP0010630_abnormal_cardiac_muscle1.32916241
52MP0010368_abnormal_lymphatic_system1.32165386
53MP0004085_abnormal_heartbeat1.32035847
54MP0000467_abnormal_esophagus_morphology1.30152024
55MP0003453_abnormal_keratinocyte_physiol1.28865305
56MP0005085_abnormal_gallbladder_physiolo1.27616524
57MP0005666_abnormal_adipose_tissue1.26726580
58MP0001666_abnormal_nutrient_absorption1.24109762
59MP0003828_pulmonary_edema1.23202306
60MP0000516_abnormal_urinary_system1.22586755
61MP0005367_renal/urinary_system_phenotyp1.22586755
62MP0004185_abnormal_adipocyte_glucose1.21864908
63MP0002139_abnormal_hepatobiliary_system1.18466735
64MP0002332_abnormal_exercise_endurance1.17642659
65MP0000747_muscle_weakness1.16984935
66MP0002098_abnormal_vibrissa_morphology1.15596559
67MP0010352_gastrointestinal_tract_polyps1.15536929
68MP0005023_abnormal_wound_healing1.14977974
69MP0000647_abnormal_sebaceous_gland1.13907669
70MP0003191_abnormal_cellular_cholesterol1.13774503
71MP0000762_abnormal_tongue_morphology1.12760054
72MP0009780_abnormal_chondrocyte_physiolo1.11345060
73MP0008775_abnormal_heart_ventricle1.11081966
74MP0003950_abnormal_plasma_membrane1.08051961
75MP0009840_abnormal_foam_cell1.06142691
76MP0005670_abnormal_white_adipose1.04505244
77MP0004381_abnormal_hair_follicle1.01162214
78MP0000003_abnormal_adipose_tissue0.99683228
79MP0005266_abnormal_metabolism0.99506617
80MP0000343_altered_response_to0.98916977
81MP0001849_ear_inflammation0.93383991
82MP0005365_abnormal_bile_salt0.93061111
83MP0009384_cardiac_valve_regurgitation0.92712414
84MP0008004_abnormal_stomach_pH0.91222398
85MP0003566_abnormal_cell_adhesion0.91103753
86MP0001929_abnormal_gametogenesis0.87538936
87MP0003315_abnormal_perineum_morphology0.84729035
88MP0004782_abnormal_surfactant_physiolog0.84603527
89MP0005375_adipose_tissue_phenotype0.80463326
90MP0002108_abnormal_muscle_morphology0.79408354
91MP0005623_abnormal_meninges_morphology0.78857678
92MP0000377_abnormal_hair_follicle0.78165369
93MP0002282_abnormal_trachea_morphology0.76554658
94MP0001765_abnormal_ion_homeostasis0.74733424
95MP0000733_abnormal_muscle_development0.74164824
96MP0005409_darkened_coat_color0.74010867
97MP0001346_abnormal_lacrimal_gland0.71954424
98MP0003879_abnormal_hair_cell0.71434377
99MP0005332_abnormal_amino_acid0.69263080
100MP0000013_abnormal_adipose_tissue0.68970522
101MP0004859_abnormal_synaptic_plasticity0.67880363
102MP0004270_analgesia0.67577892
103MP0000462_abnormal_digestive_system0.67098908
104MP0004043_abnormal_pH_regulation0.67045300
105MP0010030_abnormal_orbit_morphology0.65869482
106MP0000266_abnormal_heart_morphology0.65099717
107MP0000427_abnormal_hair_cycle0.62946583
108MP0002127_abnormal_cardiovascular_syste0.61523244
109MP0002971_abnormal_brown_adipose0.61411757
110MP0003075_altered_response_to0.60588163
111MP0010329_abnormal_lipoprotein_level0.58088016
112MP0005165_increased_susceptibility_to0.56983723
113MP0002876_abnormal_thyroid_physiology0.55524521
114MP0002896_abnormal_bone_mineralization0.55365050
115MP0003868_abnormal_feces_composition0.54830432
116MP0001784_abnormal_fluid_regulation0.53610444
117MP0000230_abnormal_systemic_arterial0.53475186
118MP0008961_abnormal_basal_metabolism0.53249929
119MP0009745_abnormal_behavioral_response0.53113583
120MP0009931_abnormal_skin_appearance0.51022817
121MP0004947_skin_inflammation0.50088791
122MP0002161_abnormal_fertility/fecundity0.49647183
123MP0004510_myositis0.49214763
124MP0001191_abnormal_skin_condition0.48268571
125MP0003283_abnormal_digestive_organ0.46693809
126MP0001984_abnormal_olfaction0.46238190
127MP0001851_eye_inflammation0.45931208
128MP0002877_abnormal_melanocyte_morpholog0.45805960

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.98075161
2Sudden death (HP:0001699)5.69537646
3Ventricular tachycardia (HP:0004756)5.46230114
4Right ventricular cardiomyopathy (HP:0011663)5.42126540
5Hyporeflexia of lower limbs (HP:0002600)5.37216691
6Exercise-induced muscle cramps (HP:0003710)5.31399080
7Muscle fiber splitting (HP:0003555)4.96565577
8Calf muscle hypertrophy (HP:0008981)4.89971012
9Muscle hypertrophy of the lower extremities (HP:0008968)4.69125703
10Absent/shortened dynein arms (HP:0200106)4.23494559
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.23494559
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.21085680
13Abnormality of the calf musculature (HP:0001430)3.99247691
14Atrial fibrillation (HP:0005110)3.88561943
15Difficulty running (HP:0009046)3.83490240
16Increased connective tissue (HP:0009025)3.75770862
17Bundle branch block (HP:0011710)3.75113333
18Muscle fiber inclusion bodies (HP:0100299)3.72508274
19Myoglobinuria (HP:0002913)3.70649644
20Primary atrial arrhythmia (HP:0001692)3.62607085
21Ventricular fibrillation (HP:0001663)3.62422444
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.51246261
23Type 1 muscle fiber predominance (HP:0003803)3.46257761
24Supraventricular tachycardia (HP:0004755)3.43785842
25Abnormality of nail color (HP:0100643)3.43697552
26Supraventricular arrhythmia (HP:0005115)3.35640143
27Plantar hyperkeratosis (HP:0007556)3.34156718
28Milia (HP:0001056)3.34071438
29Fragile nails (HP:0001808)3.28831787
30Abnormal atrioventricular conduction (HP:0005150)3.21789016
31Distal lower limb muscle weakness (HP:0009053)3.19282203
32Heart block (HP:0012722)3.17951848
33EMG: myopathic abnormalities (HP:0003458)3.13997561
34Subaortic stenosis (HP:0001682)3.10827995
35Abnormality of the left ventricular outflow tract (HP:0011103)3.10827995
36Syncope (HP:0001279)3.10523023
37Difficulty climbing stairs (HP:0003551)3.09704166
38Lipoatrophy (HP:0100578)3.01184312
39Nemaline bodies (HP:0003798)3.00221394
40Prolonged QT interval (HP:0001657)2.98599351
41Atrioventricular block (HP:0001678)2.93498662
42Abnormal respiratory motile cilium physiology (HP:0012261)2.93005473
43Hypotrichosis (HP:0001006)2.92294644
44Ventricular arrhythmia (HP:0004308)2.91947110
45Onycholysis (HP:0001806)2.91402175
46Abnormality of the neuromuscular junction (HP:0003398)2.83482957
47Fatigable weakness (HP:0003473)2.83482957
48Asymmetric septal hypertrophy (HP:0001670)2.79530667
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.78924481
50Woolly hair (HP:0002224)2.74431576
51Dilated cardiomyopathy (HP:0001644)2.68899443
52Rhabdomyolysis (HP:0003201)2.66197646
53Distal lower limb amyotrophy (HP:0008944)2.66052863
54Chronic bronchitis (HP:0004469)2.65488851
55Thick nail (HP:0001805)2.65344121
56Areflexia of lower limbs (HP:0002522)2.65283061
57Palmoplantar hyperkeratosis (HP:0000972)2.65185706
58Palmoplantar keratoderma (HP:0000982)2.59629904
59Increased variability in muscle fiber diameter (HP:0003557)2.58251414
60Myotonia (HP:0002486)2.56287672
61Male infertility (HP:0003251)2.55830084
62Abnormality of the salivary glands (HP:0010286)2.53942224
63Muscle stiffness (HP:0003552)2.52301928
64Increased IgE level (HP:0003212)2.50213132
65Abnormality of the 1st metacarpal (HP:0010009)2.49918986
66Abnormality of skeletal muscle fiber size (HP:0012084)2.41730053
67Palmar hyperkeratosis (HP:0010765)2.38450538
68Palpitations (HP:0001962)2.37927358
69Dysmetric saccades (HP:0000641)2.36534608
70Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.35611849
71Short 1st metacarpal (HP:0010034)2.35611849
72Neck muscle weakness (HP:0000467)2.34623318
73Infertility (HP:0000789)2.33237024
74Atrophic scars (HP:0001075)2.33205693
75Abnormal respiratory motile cilium morphology (HP:0005938)2.33048546
76Abnormal respiratory epithelium morphology (HP:0012253)2.33048546
77Distal arthrogryposis (HP:0005684)2.29223612
78Abnormal EKG (HP:0003115)2.24344045
79Abnormality of secondary sexual hair (HP:0009888)2.22772395
80Abnormality of the axillary hair (HP:0100134)2.22772395
81Congenital ichthyosiform erythroderma (HP:0007431)2.18460302
82Lower limb amyotrophy (HP:0007210)2.17249830
83Ragged-red muscle fibers (HP:0003200)2.16757277
84Corneal erosion (HP:0200020)2.16224644
85Pili torti (HP:0003777)2.16122049
86Round ear (HP:0100830)2.15276798
87Calcaneovalgus deformity (HP:0001848)2.11923129
88Rhinitis (HP:0012384)2.10854216
89Myopathic facies (HP:0002058)2.10839941
90Lip pit (HP:0100267)2.10539083
91Conjunctival hamartoma (HP:0100780)2.09439711
92Sudden cardiac death (HP:0001645)2.09197036
93Deformed tarsal bones (HP:0008119)2.09146254
94Amelogenesis imperfecta (HP:0000705)2.08704729
95Nail dystrophy (HP:0008404)2.06536827
96Abnormal hair laboratory examination (HP:0003328)2.06471537
97Abnormal ciliary motility (HP:0012262)2.04634007
98Decreased circulating renin level (HP:0003351)2.03867464
99EMG: neuropathic changes (HP:0003445)2.03607802
100Erythroderma (HP:0001019)2.00772153
101Short hallux (HP:0010109)2.00554288
102Double outlet right ventricle (HP:0001719)1.97666836
103Congenital malformation of the right heart (HP:0011723)1.97666836
104Malnutrition (HP:0004395)1.96980413
105Abnormality of the foot musculature (HP:0001436)1.95491746
106Abnormal blistering of the skin (HP:0008066)1.95152251
107Weak cry (HP:0001612)1.94057872
108Short phalanx of the thumb (HP:0009660)1.92146445
109Mildly elevated creatine phosphokinase (HP:0008180)1.92004604
110Gowers sign (HP:0003391)1.88855189
111Erythema (HP:0010783)1.88849204
112Nasal polyposis (HP:0100582)1.85875180
113Rimmed vacuoles (HP:0003805)1.84252260
114Abnormality of glutamine family amino acid metabolism (HP:0010902)1.83072352
115Left ventricular hypertrophy (HP:0001712)1.82113586
116Septate vagina (HP:0001153)1.81188671
117Aplasia/Hypoplasia of the hallux (HP:0008362)1.80647659
118Acanthosis nigricans (HP:0000956)1.80569377
119Bradycardia (HP:0001662)1.80549581
120Abnormality of the nasal mucosa (HP:0000433)1.80532525
121Hamartoma of the eye (HP:0010568)1.79930115
122Abnormality of lateral ventricle (HP:0030047)1.79555931
123Alopecia of scalp (HP:0002293)1.75871150
124Hypoplasia of dental enamel (HP:0006297)1.75275735
125Foot dorsiflexor weakness (HP:0009027)1.75251519
126Hyperkalemia (HP:0002153)1.75219849
127Sparse eyelashes (HP:0000653)1.73884975
128Generalized muscle weakness (HP:0003324)1.73125406
129Skin pits (HP:0100276)1.72606755
130Late onset (HP:0003584)1.69107561
131Fragile skin (HP:0001030)1.67614145
132Abnormality of proline metabolism (HP:0010907)1.67551424
133Hydroxyprolinuria (HP:0003080)1.67551424
134Ridged nail (HP:0001807)1.67166295
135Hypoplastic left heart (HP:0004383)1.66725457
136Popliteal pterygium (HP:0009756)1.65899114
137Hyperactive renin-angiotensin system (HP:0000841)1.65185819
138Abnormality of monocarboxylic acid metabolism (HP:0010996)1.63367936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.44669400
2PDK44.44669400
3EPHA23.83909040
4TTN3.69436837
5MST1R3.56663199
6MAP3K73.54821123
7OBSCN3.47575326
8PDK22.85313136
9PRKD32.77970346
10TESK12.56302959
11EPHA42.53535616
12PHKG12.50853800
13PHKG22.50853800
14LMTK22.15303043
15DMPK2.14089414
16CAMKK22.01516067
17ICK1.94901900
18MUSK1.81261593
19MAP3K61.73689475
20STK111.57168858
21PINK11.49417586
22ARAF1.46213073
23LIMK11.39177920
24MYLK1.38476462
25GRK71.35260857
26TRIB31.34341436
27CAMKK11.33219780
28PRKAA21.31488650
29TAOK11.26344684
30STK381.26343219
31MAP3K31.26182026
32DYRK1B1.24261591
33EPHB21.23320360
34RIPK41.22707881
35NME11.21107631
36PTK21.15900637
37MAPKAPK31.13614178
38TGFBR21.12915712
39NEK91.03944211
40ERN11.03150717
41SIK11.00203651
42MAP3K90.92103513
43PRKD10.92032365
44PRKAA10.90430472
45WNK40.88401852
46MET0.87699968
47FRK0.86932527
48PRKG20.85236794
49PLK40.85123499
50TGFBR10.84828126
51MAPK70.83004543
52PIK3CA0.82843398
53CAMK1D0.82595754
54FER0.82397386
55PTK2B0.81724461
56PTK60.81663709
57MOS0.81522005
58TRPM70.80625910
59PDK10.80427005
60NEK10.77881268
61MAP3K20.76239166
62KSR20.75809408
63RIPK10.75031889
64EEF2K0.73038384
65STK240.72587968
66PDPK10.72062913
67MAP2K60.71436585
68MAP3K120.70006301
69PIK3CG0.69025012
70FGFR10.68569565
71TYRO30.65006849
72PKN20.64633381
73MAP3K10.62247030
74TIE10.61821010
75CAMK1G0.61760947
76PIM20.61398493
77STK390.61298260
78DDR20.59582660
79EPHA30.58946211
80ROCK20.58636652
81MST40.58026985
82WNK10.57936489
83FGFR40.56332950
84CAMK2D0.54856867
85LATS10.54747008
86DAPK30.51475101
87ROCK10.50854649
88MAP3K130.50413262
89PAK30.50097703
90CAMK10.48920869
91STK40.48633554
92MTOR0.46748884
93RAF10.46643308
94FGFR30.46498085
95NTRK20.46176371
96CAMK40.45701983
97MAP2K10.45673930
98ERBB40.45274245
99ERBB30.44513870
100CAMK2A0.44311864
101PRKACG0.42683550
102LATS20.41349893
103PRKD20.40443807
104MAPK110.39516091
105MAPK120.39373030
106STK100.38482251
107STK38L0.38146371
108MARK20.38050226
109RPS6KL10.37695199
110RPS6KC10.37695199
111ILK0.37492078
112AKT20.36763267
113PAK40.36273734
114GRK50.35171555
115MAP3K50.35032885
116STK30.34492745
117PRKACA0.33505609
118CAMK2B0.33225691
119RPS6KB20.31115053
120PRKCH0.30635862
121MAPKAPK20.29676446
122RPS6KA10.29674532
123RPS6KA60.29389794
124JAK20.29175669
125FLT30.29041892
126FGFR20.28821398
127NTRK30.28102051
128PKN10.27576061
129PAK60.27336610
130IRAK30.26660626
131LRRK20.26273119
132CAMK2G0.26117151
133PBK0.25774450
134PRKCE0.25312364
135RET0.25245812
136DAPK20.25241947
137PDGFRA0.25081756
138EPHB10.24698502
139CDC42BPA0.24089456
140RPS6KA20.23935123
141PRKCQ0.22406978

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.31067736
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.85899783
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.83424407
4Linoleic acid metabolism_Homo sapiens_hsa005912.77073897
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.53090448
6Dilated cardiomyopathy_Homo sapiens_hsa054142.45611465
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.13545622
8Arginine biosynthesis_Homo sapiens_hsa002202.11762975
9Parkinsons disease_Homo sapiens_hsa050122.09194194
10Oxidative phosphorylation_Homo sapiens_hsa001901.93684335
11Propanoate metabolism_Homo sapiens_hsa006401.87561159
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.87386354
13Alzheimers disease_Homo sapiens_hsa050101.76805696
14Arginine and proline metabolism_Homo sapiens_hsa003301.74103834
15Glucagon signaling pathway_Homo sapiens_hsa049221.73799694
16Histidine metabolism_Homo sapiens_hsa003401.71839113
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64598046
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63046221
19Fatty acid biosynthesis_Homo sapiens_hsa000611.61256221
20Fat digestion and absorption_Homo sapiens_hsa049751.59296840
21Renin secretion_Homo sapiens_hsa049241.54866297
22Circadian rhythm_Homo sapiens_hsa047101.49366705
23Fatty acid degradation_Homo sapiens_hsa000711.49214933
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.49212328
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.42053556
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40693916
27Calcium signaling pathway_Homo sapiens_hsa040201.39637233
28Oxytocin signaling pathway_Homo sapiens_hsa049211.38549335
29Gastric acid secretion_Homo sapiens_hsa049711.37424046
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.36005845
31Huntingtons disease_Homo sapiens_hsa050161.35431564
32Ether lipid metabolism_Homo sapiens_hsa005651.34817231
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.28774354
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28389275
35Arachidonic acid metabolism_Homo sapiens_hsa005901.28239166
36Sulfur metabolism_Homo sapiens_hsa009201.26365749
37Olfactory transduction_Homo sapiens_hsa047401.24503388
38Salivary secretion_Homo sapiens_hsa049701.23883590
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23513057
40Amphetamine addiction_Homo sapiens_hsa050311.22421061
41Pancreatic secretion_Homo sapiens_hsa049721.22383811
42Carbon metabolism_Homo sapiens_hsa012001.20138059
43Protein digestion and absorption_Homo sapiens_hsa049741.12441010
44Tyrosine metabolism_Homo sapiens_hsa003501.12308474
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11712567
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09694026
47Galactose metabolism_Homo sapiens_hsa000521.08422616
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07566708
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07534377
50Fatty acid metabolism_Homo sapiens_hsa012121.04787402
51Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03515908
52Cocaine addiction_Homo sapiens_hsa050301.01374294
53Tight junction_Homo sapiens_hsa045301.01333342
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00762425
55Tryptophan metabolism_Homo sapiens_hsa003801.00040027
56Renin-angiotensin system_Homo sapiens_hsa046140.98529241
57Long-term potentiation_Homo sapiens_hsa047200.97927106
58Pyruvate metabolism_Homo sapiens_hsa006200.95294643
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94249897
60GnRH signaling pathway_Homo sapiens_hsa049120.93364662
61Circadian entrainment_Homo sapiens_hsa047130.93182783
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92788115
63Insulin secretion_Homo sapiens_hsa049110.91862699
64Mineral absorption_Homo sapiens_hsa049780.91788923
65Vitamin digestion and absorption_Homo sapiens_hsa049770.90855005
66PPAR signaling pathway_Homo sapiens_hsa033200.89617565
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89411676
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88995497
69Caffeine metabolism_Homo sapiens_hsa002320.87130432
70Insulin resistance_Homo sapiens_hsa049310.85414340
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84247298
72Starch and sucrose metabolism_Homo sapiens_hsa005000.82788599
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82618008
74Biosynthesis of amino acids_Homo sapiens_hsa012300.81210615
75Dorso-ventral axis formation_Homo sapiens_hsa043200.80161924
76Fatty acid elongation_Homo sapiens_hsa000620.79917271
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.79706035
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.78883118
79Insulin signaling pathway_Homo sapiens_hsa049100.77831790
80Complement and coagulation cascades_Homo sapiens_hsa046100.77292429
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75664928
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73355344
83Cholinergic synapse_Homo sapiens_hsa047250.73304638
84Fructose and mannose metabolism_Homo sapiens_hsa000510.71212237
85cAMP signaling pathway_Homo sapiens_hsa040240.69499875
86Nitrogen metabolism_Homo sapiens_hsa009100.65575696
87Dopaminergic synapse_Homo sapiens_hsa047280.64773894
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64525929
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.64403777
90Chemical carcinogenesis_Homo sapiens_hsa052040.63549496
91Phenylalanine metabolism_Homo sapiens_hsa003600.62389024
92Sphingolipid metabolism_Homo sapiens_hsa006000.62355874
93AMPK signaling pathway_Homo sapiens_hsa041520.62297367
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61184175
95Adherens junction_Homo sapiens_hsa045200.61061866
96Inositol phosphate metabolism_Homo sapiens_hsa005620.60597023
97VEGF signaling pathway_Homo sapiens_hsa043700.60162978
98Estrogen signaling pathway_Homo sapiens_hsa049150.59613367
99ECM-receptor interaction_Homo sapiens_hsa045120.57025775
100Gap junction_Homo sapiens_hsa045400.56615166
101Taste transduction_Homo sapiens_hsa047420.56395759
102Sulfur relay system_Homo sapiens_hsa041220.56087026
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.54941359
104beta-Alanine metabolism_Homo sapiens_hsa004100.54940124
105Glutamatergic synapse_Homo sapiens_hsa047240.54086766
106Melanogenesis_Homo sapiens_hsa049160.53768137
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52032690
108Bile secretion_Homo sapiens_hsa049760.51968346
109ABC transporters_Homo sapiens_hsa020100.51308526
110Viral myocarditis_Homo sapiens_hsa054160.49551502
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47918316
112Pentose phosphate pathway_Homo sapiens_hsa000300.47184469
113Morphine addiction_Homo sapiens_hsa050320.46407631
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44904064
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43769789
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42651199
117Amoebiasis_Homo sapiens_hsa051460.41892652
118Butanoate metabolism_Homo sapiens_hsa006500.41414296
119Hedgehog signaling pathway_Homo sapiens_hsa043400.40861160
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40781301
121Basal cell carcinoma_Homo sapiens_hsa052170.40685677
122Type II diabetes mellitus_Homo sapiens_hsa049300.40117825
123mTOR signaling pathway_Homo sapiens_hsa041500.40038072
124Retinol metabolism_Homo sapiens_hsa008300.38641064
125Glycerolipid metabolism_Homo sapiens_hsa005610.38474331
126Focal adhesion_Homo sapiens_hsa045100.37524620
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37224013
128Ovarian steroidogenesis_Homo sapiens_hsa049130.36983164
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36551841
130Peroxisome_Homo sapiens_hsa041460.36458444
131Serotonergic synapse_Homo sapiens_hsa047260.35921185
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34156844
133Thyroid hormone synthesis_Homo sapiens_hsa049180.33587646
134Glutathione metabolism_Homo sapiens_hsa004800.33504986
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.33146526
136Small cell lung cancer_Homo sapiens_hsa052220.30788579

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