SH3RF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.22812669
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.17602224
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.16443410
4locomotory exploration behavior (GO:0035641)5.04115328
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.01291382
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.71779263
7regulation of glutamate receptor signaling pathway (GO:1900449)4.65451760
8neuron cell-cell adhesion (GO:0007158)4.44583156
9protein localization to synapse (GO:0035418)4.43264404
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.43125402
11negative regulation of synaptic transmission, GABAergic (GO:0032229)4.30640186
12presynaptic membrane assembly (GO:0097105)4.26396095
13postsynaptic membrane organization (GO:0001941)4.24858794
14synaptic vesicle maturation (GO:0016188)4.11061926
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.11051426
16exploration behavior (GO:0035640)4.10654074
17response to pheromone (GO:0019236)4.07459992
18regulation of synaptic vesicle exocytosis (GO:2000300)4.06688832
19dendritic spine morphogenesis (GO:0060997)4.03883734
20protein heterotrimerization (GO:0070208)4.00018094
21central nervous system projection neuron axonogenesis (GO:0021952)3.97379833
22synaptic vesicle exocytosis (GO:0016079)3.96370837
23skin morphogenesis (GO:0043589)3.96297334
24synaptic transmission, glutamatergic (GO:0035249)3.94880517
25glutamate receptor signaling pathway (GO:0007215)3.93719921
26presynaptic membrane organization (GO:0097090)3.92787162
27neurotransmitter-gated ion channel clustering (GO:0072578)3.90352749
28cerebral cortex radially oriented cell migration (GO:0021799)3.87200193
29glutamate secretion (GO:0014047)3.86948398
30layer formation in cerebral cortex (GO:0021819)3.78957756
31neuron recognition (GO:0008038)3.77684831
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.70729083
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69158086
34barbed-end actin filament capping (GO:0051016)3.64033691
35kidney mesenchyme development (GO:0072074)3.63365692
36neuron-neuron synaptic transmission (GO:0007270)3.60262731
37collagen fibril organization (GO:0030199)3.58593548
38proline transport (GO:0015824)3.56636370
39regulation of synaptic vesicle transport (GO:1902803)3.56545842
40dendrite morphogenesis (GO:0048813)3.53770366
41cell migration involved in heart development (GO:0060973)3.53290740
42axonal fasciculation (GO:0007413)3.52084620
43negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.47719861
44pyrimidine nucleobase catabolic process (GO:0006208)3.45445152
45protein localization to endosome (GO:0036010)3.43586608
46synaptic vesicle endocytosis (GO:0048488)3.41060893
47regulation of neuronal synaptic plasticity (GO:0048168)3.41026806
48metanephric mesenchyme development (GO:0072075)3.34477414
49cell migration in hindbrain (GO:0021535)3.34364130
50long-term memory (GO:0007616)3.34235753
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32744172
52regulation of synapse structural plasticity (GO:0051823)3.32188716
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26206630
54positive regulation of synapse maturation (GO:0090129)3.25787848
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.22323937
56positive regulation of membrane potential (GO:0045838)3.22224937
57stress fiber assembly (GO:0043149)3.20795230
58endodermal cell differentiation (GO:0035987)3.18997240
59positive regulation of neurotransmitter secretion (GO:0001956)3.17488369
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16391981
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15791518
62dendritic spine organization (GO:0097061)3.15670538
63extracellular matrix assembly (GO:0085029)3.15282350
64central nervous system neuron axonogenesis (GO:0021955)3.15271668
65positive regulation of receptor recycling (GO:0001921)3.13609275
66regulation of postsynaptic membrane potential (GO:0060078)3.13257115
67positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11669402
68apoptotic cell clearance (GO:0043277)3.11382546
69substrate-dependent cell migration (GO:0006929)3.10503598
70gamma-aminobutyric acid signaling pathway (GO:0007214)3.10325672
71vascular endothelial growth factor signaling pathway (GO:0038084)3.08555554
72neurotransmitter secretion (GO:0007269)3.03977899
73bone trabecula formation (GO:0060346)3.03456336
74regulation of dendritic spine morphogenesis (GO:0061001)3.01415116
75regulation of synaptic transmission, GABAergic (GO:0032228)3.00792421
76startle response (GO:0001964)2.99283307
77regulation of neurotransmitter secretion (GO:0046928)2.96929803
78vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.96662492
79cell-substrate junction assembly (GO:0007044)2.96426060
80nucleobase catabolic process (GO:0046113)2.94459598
81positive regulation of blood vessel endothelial cell migration (GO:0043536)2.94251525
82extracellular fibril organization (GO:0043206)2.93403028
83gamma-aminobutyric acid transport (GO:0015812)2.92525338
84response to auditory stimulus (GO:0010996)2.91955322
85regulation of synapse maturation (GO:0090128)2.91907943
86synapse assembly (GO:0007416)2.90647828
87adherens junction assembly (GO:0034333)2.89795704
88regulation of synaptic plasticity (GO:0048167)2.87862496
89tooth mineralization (GO:0034505)2.86901068
90basement membrane organization (GO:0071711)2.84426442
91chondroitin sulfate biosynthetic process (GO:0030206)2.84166938
92virion attachment to host cell (GO:0019062)2.84032819
93adhesion of symbiont to host cell (GO:0044650)2.84032819
94positive regulation of fibroblast migration (GO:0010763)2.83455204
95regulation of dendritic spine development (GO:0060998)2.82716823
96neuronal action potential propagation (GO:0019227)2.81518641
97long-term synaptic potentiation (GO:0060291)2.81142537
98auditory behavior (GO:0031223)2.80220464
99cortical actin cytoskeleton organization (GO:0030866)2.79667019
100positive regulation of neurotransmitter transport (GO:0051590)2.79621442
101positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79348211
102learning (GO:0007612)2.78365370
103blood vessel maturation (GO:0001955)2.78043769
104collagen metabolic process (GO:0032963)2.77674477
105cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.76320519
106cell-substrate adherens junction assembly (GO:0007045)2.75911867
107focal adhesion assembly (GO:0048041)2.75911867
108regulation of synapse assembly (GO:0051963)2.75607620
109dermatan sulfate biosynthetic process (GO:0030208)2.74770783
110dermatan sulfate metabolic process (GO:0030205)2.74342476
111behavioral defense response (GO:0002209)2.73766361
112behavioral fear response (GO:0001662)2.73766361
113fibril organization (GO:0097435)2.72834880
114planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71869055
115mesenchymal-epithelial cell signaling (GO:0060638)2.71591915
116cell adhesion mediated by integrin (GO:0033627)2.71198253
117collagen catabolic process (GO:0030574)2.70516969
118positive regulation of synapse assembly (GO:0051965)2.69859146
119positive regulation of dendritic spine morphogenesis (GO:0061003)2.69624524
120cerebellar granule cell differentiation (GO:0021707)2.69464859
121dendrite development (GO:0016358)2.68937400
122positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.68801631
123regulation of neurotransmitter transport (GO:0051588)2.68643521
124glycine transport (GO:0015816)2.68507923
125hypotonic response (GO:0006971)2.67221415
126lymph vessel development (GO:0001945)2.65987268
127negative regulation of smooth muscle cell migration (GO:0014912)2.64662295
128negative regulation of fatty acid transport (GO:2000192)2.62536876
129regulation of synapse organization (GO:0050807)2.62119579
130axon extension (GO:0048675)2.61620041
131positive regulation of filopodium assembly (GO:0051491)2.60206862
132venous blood vessel morphogenesis (GO:0048845)2.59816756
133cortical cytoskeleton organization (GO:0030865)2.59389181
134transmission of nerve impulse (GO:0019226)2.57632640
135positive regulation of dendritic spine development (GO:0060999)2.57543194
136regulation of early endosome to late endosome transport (GO:2000641)2.57185204
137cytoskeletal anchoring at plasma membrane (GO:0007016)2.56345015
138wound healing, spreading of epidermal cells (GO:0035313)2.56341968
139negative regulation of dendrite development (GO:2000171)2.56224294
140membrane depolarization (GO:0051899)2.56006445
141multicellular organismal macromolecule metabolic process (GO:0044259)2.55698327
142organelle transport along microtubule (GO:0072384)2.55543847
143neuronal ion channel clustering (GO:0045161)2.54803899
144regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53036193
145adhesion of symbiont to host (GO:0044406)2.52781419
146regulation of cAMP-dependent protein kinase activity (GO:2000479)2.51661703
147cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.51508828
148membrane hyperpolarization (GO:0060081)2.51340832
149peptidyl-proline hydroxylation (GO:0019511)2.51139361
150righting reflex (GO:0060013)2.50908538
151protein targeting to plasma membrane (GO:0072661)2.49749563
152long term synaptic depression (GO:0060292)2.49694154
153regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.47170784
154response to histamine (GO:0034776)2.46232985
155innervation (GO:0060384)2.46225574
156regulation of synaptic transmission (GO:0050804)2.45352647
157cerebellum development (GO:0021549)2.45296605
158multicellular organismal catabolic process (GO:0044243)2.43530806
159chondrocyte proliferation (GO:0035988)2.41383850
160extracellular matrix disassembly (GO:0022617)2.41363954
161positive regulation of osteoblast proliferation (GO:0033690)2.41138284
162response to fluid shear stress (GO:0034405)2.38856873
163multicellular organismal metabolic process (GO:0044236)2.38748758
164positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.37895700
165positive regulation of axon extension (GO:0045773)2.36972877
166embryonic viscerocranium morphogenesis (GO:0048703)2.36698534
167semaphorin-plexin signaling pathway (GO:0071526)2.36397375
168regulation of extracellular matrix disassembly (GO:0010715)2.36197173
169positive regulation of astrocyte differentiation (GO:0048711)2.35212985
170keratan sulfate catabolic process (GO:0042340)2.34519989
171cellular response to epinephrine stimulus (GO:0071872)2.34355184
172protein hydroxylation (GO:0018126)2.33529594
173platelet-derived growth factor receptor signaling pathway (GO:0048008)2.31880551
174response to laminar fluid shear stress (GO:0034616)2.31628057
175positive regulation of extracellular matrix organization (GO:1903055)2.31354358
176regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.30553545
177type B pancreatic cell proliferation (GO:0044342)2.29496960
178chondrocyte development (GO:0002063)2.29029085
179regulation of macrophage cytokine production (GO:0010935)2.25443604
180chondroitin sulfate catabolic process (GO:0030207)2.24581080
181negative regulation of anoikis (GO:2000811)2.23132913
182dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.23127155
183lymphangiogenesis (GO:0001946)2.22942818
184phagocytosis, recognition (GO:0006910)2.22458696
185endothelial cell chemotaxis (GO:0035767)2.20625542
186peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.20194247
187neuron projection extension (GO:1990138)2.19291103
188replacement ossification (GO:0036075)2.18925512
189endochondral ossification (GO:0001958)2.18925512
190regulation of axon extension involved in axon guidance (GO:0048841)2.18734025
191cardiac myofibril assembly (GO:0055003)2.17864711
192extracellular matrix organization (GO:0030198)2.17146207
193wound healing, spreading of cells (GO:0044319)2.16550984
194extracellular structure organization (GO:0043062)2.16026781
195retina vasculature morphogenesis in camera-type eye (GO:0061299)2.15307233
196sequestering of extracellular ligand from receptor (GO:0035581)2.12134716
197hemidesmosome assembly (GO:0031581)2.12056932
198Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.10010687
199heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.09975216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.63239193
2GBX2_23144817_ChIP-Seq_PC3_Human4.18428627
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.43871831
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.40277973
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.91007804
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84494438
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69831855
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64353429
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.58899699
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51363664
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.47983318
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44261124
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44261124
14* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.36119905
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35662709
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33739329
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32072712
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32010964
19* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.28128466
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.26859161
21* ELK3_25401928_ChIP-Seq_HUVEC_Human2.25315030
22* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22474427
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11230890
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.06144200
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04496488
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02351260
27* REST_21632747_ChIP-Seq_MESCs_Mouse2.01701242
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01698634
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.99073802
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98935956
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97817217
32LXR_22292898_ChIP-Seq_THP-1_Human1.97296323
33AR_21572438_ChIP-Seq_LNCaP_Human1.95603618
34DROSHA_22980978_ChIP-Seq_HELA_Human1.94070137
35CLOCK_20551151_ChIP-Seq_293T_Human1.91029825
36* EZH2_27294783_Chip-Seq_ESCs_Mouse1.90839750
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89195741
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.86985341
39KDM2B_26808549_Chip-Seq_K562_Human1.85368509
40IGF1R_20145208_ChIP-Seq_DFB_Human1.83723745
41* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82106403
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80796621
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80616995
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.78073944
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77667614
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.76884097
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.75712209
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75613381
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.74650480
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.71679060
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67169052
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.62629586
53TBX20_22080862_ChIP-Seq_HEART_Mouse1.62629586
54P300_19829295_ChIP-Seq_ESCs_Human1.62292417
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61843106
56KDM2B_26808549_Chip-Seq_DND41_Human1.61105750
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57860071
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.57437017
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57064080
60* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57062719
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56847307
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56402293
63TAF15_26573619_Chip-Seq_HEK293_Human1.56133074
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54680629
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53711976
66* RARB_27405468_Chip-Seq_BRAIN_Mouse1.53291376
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51863019
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51240902
69* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.47341898
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.47192040
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45675853
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.44295348
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44063926
74* KDM2B_26808549_Chip-Seq_JURKAT_Human1.43244206
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42808715
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42603745
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.41241218
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40934938
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.40735210
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.40620830
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40305690
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39443737
83RACK7_27058665_Chip-Seq_MCF-7_Human1.39399677
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38609023
85* STAT3_23295773_ChIP-Seq_U87_Human1.38005206
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36508308
87RNF2_27304074_Chip-Seq_NSC_Mouse1.35990531
88TCF7_22412390_ChIP-Seq_EML_Mouse1.35866000
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35203621
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34814600
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34541785
92AR_25329375_ChIP-Seq_VCAP_Human1.33235758
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.32622763
94VDR_21846776_ChIP-Seq_THP-1_Human1.31539522
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30661421
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.30551000
97BRD4_25478319_ChIP-Seq_HGPS_Human1.30304475
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29730392
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.28918353
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28410421
101* TP53_23651856_ChIP-Seq_MEFs_Mouse1.28343213
102FUS_26573619_Chip-Seq_HEK293_Human1.27547162
103TP53_16413492_ChIP-PET_HCT116_Human1.27259696
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.25812072
105* TCF4_23295773_ChIP-Seq_U87_Human1.25655105
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25505339
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.25016063
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.24974679
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24420942
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23896923
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23836122
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23485469
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23267520
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22483242
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22036412
116YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22009241
117TP53_22127205_ChIP-Seq_IMR90_Human1.21168478
118* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21136470
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.20248796
120AR_19668381_ChIP-Seq_PC3_Human1.20206354
121TP53_18474530_ChIP-ChIP_U2OS_Human1.19990048
122SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19520642
123* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19511625
124* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19511625
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18297246
126ER_23166858_ChIP-Seq_MCF-7_Human1.17781427
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17710274
128ARNT_22903824_ChIP-Seq_MCF-7_Human1.16071982
129* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16069132
130* CJUN_26792858_Chip-Seq_BT549_Human1.15706880
131TCF4_18268006_ChIP-ChIP_LS174T_Human1.15493818
132RUNX2_22187159_ChIP-Seq_PCA_Human1.15210867
133RING1B_27294783_Chip-Seq_ESCs_Mouse1.14994083
134CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14639066
135NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13699325
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13526542
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12662061
138* RING1B_27294783_Chip-Seq_NPCs_Mouse1.11948860
139TP53_20018659_ChIP-ChIP_R1E_Mouse1.11276865
140SMAD3_21741376_ChIP-Seq_HESCs_Human1.10605816
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10101114
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08477009
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08443052
144SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08376603
145CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08361010
146CMYC_18555785_Chip-Seq_ESCs_Mouse1.07862178
147DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07597134
148JUN_21703547_ChIP-Seq_K562_Human1.06906497
149MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06656602
150VDR_24763502_ChIP-Seq_THP-1_Human1.06654802
151P53_22387025_ChIP-Seq_ESCs_Mouse1.05440232
152NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04939777
153* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04615936
154SMAD4_21741376_ChIP-Seq_HESCs_Human1.04502164
155PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03061739
156NFE2_27457419_Chip-Seq_LIVER_Mouse1.02851924
157NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02156595
158SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01799786
159* TET1_21490601_ChIP-Seq_MESCs_Mouse1.01772938
160TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01262921
161EGR1_19374776_ChIP-ChIP_THP-1_Human1.01110476
162AHR_22903824_ChIP-Seq_MCF-7_Human1.00801171
163UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99661232
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99564511
165KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99295587
166ERG_21242973_ChIP-ChIP_JURKAT_Human0.98684450
167SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98600249
168TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98376118
169* SA1_22415368_ChIP-Seq_MEFs_Mouse0.97662206
170* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94069240
171* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93900952
172VDR_24787735_ChIP-Seq_THP-1_Human0.93607731
173SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93511865
174SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93511865
175GATA1_19941827_ChIP-Seq_MEL_Mouse0.93398659
176NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92795265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.20725695
2MP0004859_abnormal_synaptic_plasticity5.92520754
3MP0003705_abnormal_hypodermis_morpholog4.34974858
4MP0003279_aneurysm3.78732296
5MP0003635_abnormal_synaptic_transmissio3.56952619
6MP0003880_abnormal_central_pattern3.38512734
7MP0001958_emphysema3.30940378
8MP0005275_abnormal_skin_tensile3.20465350
9MP0004270_analgesia3.04274284
10MP0010368_abnormal_lymphatic_system3.01458868
11MP0002063_abnormal_learning/memory/cond3.01108181
12MP0000751_myopathy2.98290056
13MP0004272_abnormal_basement_membrane2.96250841
14MP0009745_abnormal_behavioral_response2.86826352
15MP0003787_abnormal_imprinting2.75908382
16MP0001188_hyperpigmentation2.74841973
17MP0005623_abnormal_meninges_morphology2.58926453
18MP0002572_abnormal_emotion/affect_behav2.55202160
19MP0000569_abnormal_digit_pigmentation2.53689610
20MP0001486_abnormal_startle_reflex2.48691572
21MP0001968_abnormal_touch/_nociception2.47610977
22MP0002734_abnormal_mechanical_nocicepti2.46588380
23MP0003566_abnormal_cell_adhesion2.46322358
24MP0000778_abnormal_nervous_system2.41702784
25MP0005423_abnormal_somatic_nervous2.41231964
26MP0005257_abnormal_intraocular_pressure2.40219496
27MP0003091_abnormal_cell_migration2.38629120
28MP0009046_muscle_twitch2.38573546
29MP0002064_seizures2.34695527
30MP0006292_abnormal_olfactory_placode2.30651169
31MP0000566_synostosis2.12421237
32MP0002735_abnormal_chemical_nociception2.09033434
33MP0002736_abnormal_nociception_after2.00355931
34MP0001542_abnormal_bone_strength1.91648395
35MP0005646_abnormal_pituitary_gland1.88737146
36MP0002184_abnormal_innervation1.84130575
37MP0000767_abnormal_smooth_muscle1.84072449
38MP0005645_abnormal_hypothalamus_physiol1.83042465
39MP0002557_abnormal_social/conspecific_i1.78263642
40MP0000013_abnormal_adipose_tissue1.76656465
41MP0005023_abnormal_wound_healing1.74921412
42MP0002102_abnormal_ear_morphology1.70614249
43MP0000749_muscle_degeneration1.69880528
44MP0003828_pulmonary_edema1.66646476
45MP0009780_abnormal_chondrocyte_physiolo1.64921394
46MP0002272_abnormal_nervous_system1.64644798
47MP0001440_abnormal_grooming_behavior1.64100286
48MP0002896_abnormal_bone_mineralization1.63510099
49MP0001970_abnormal_pain_threshold1.63305966
50MP0001879_abnormal_lymphatic_vessel1.61980621
51MP0000733_abnormal_muscle_development1.58295312
52MP0002877_abnormal_melanocyte_morpholog1.58199246
53MP0003879_abnormal_hair_cell1.57639299
54MP0002733_abnormal_thermal_nociception1.57307298
55MP0002295_abnormal_pulmonary_circulatio1.52627535
56MP0010030_abnormal_orbit_morphology1.52329609
57MP0002067_abnormal_sensory_capabilities1.52323453
58MP0005508_abnormal_skeleton_morphology1.52032454
59MP0003191_abnormal_cellular_cholesterol1.51987802
60MP0000759_abnormal_skeletal_muscle1.50865697
61MP0004811_abnormal_neuron_physiology1.49751960
62MP0002108_abnormal_muscle_morphology1.47897563
63MP0001501_abnormal_sleep_pattern1.47557152
64MP0005595_abnormal_vascular_smooth1.40209918
65MP0003329_amyloid_beta_deposits1.40031266
66MP0000631_abnormal_neuroendocrine_gland1.39650416
67MP0003950_abnormal_plasma_membrane1.39328853
68MP0004858_abnormal_nervous_system1.37149093
69MP0003300_gastrointestinal_ulcer1.37138470
70MP0001299_abnormal_eye_distance/1.35736009
71MP0006054_spinal_hemorrhage1.34892375
72MP0005451_abnormal_body_composition1.31399333
73MP0004885_abnormal_endolymph1.30601947
74MP0005386_behavior/neurological_phenoty1.30397273
75MP0004924_abnormal_behavior1.30397273
76MP0008569_lethality_at_weaning1.30281770
77MP0000955_abnormal_spinal_cord1.29418828
78MP0001984_abnormal_olfaction1.29210240
79MP0002998_abnormal_bone_remodeling1.28936249
80MP0000003_abnormal_adipose_tissue1.25097898
81MP0002060_abnormal_skin_morphology1.24184733
82MP0004130_abnormal_muscle_cell1.23083430
83MP0002882_abnormal_neuron_morphology1.22631298
84MP0003385_abnormal_body_wall1.20752893
85MP0006276_abnormal_autonomic_nervous1.19496609
86MP0004087_abnormal_muscle_fiber1.17941154
87MP0009250_abnormal_appendicular_skeleto1.17018270
88MP0009840_abnormal_foam_cell1.15845812
89MP0003122_maternal_imprinting1.15210431
90MP0005390_skeleton_phenotype1.13338588
91MP0002066_abnormal_motor_capabilities/c1.13225258
92MP0000747_muscle_weakness1.13174729
93MP0004036_abnormal_muscle_relaxation1.12268297
94MP0001177_atelectasis1.11967910
95MP0005171_absent_coat_pigmentation1.11566142
96MP0001502_abnormal_circadian_rhythm1.11495535
97MP0002152_abnormal_brain_morphology1.11494781
98MP0005164_abnormal_response_to1.09259492
99MP0000604_amyloidosis1.08632263
100MP0001533_abnormal_skeleton_physiology1.08181344
101MP0000534_abnormal_ureter_morphology1.07423239
102MP0003121_genomic_imprinting1.04809230
103MP0000343_altered_response_to1.03677280
104MP0000049_abnormal_middle_ear1.03058384
105MP0004233_abnormal_muscle_weight1.01816409
106MP0006138_congestive_heart_failure1.01789932
107MP0001243_abnormal_dermal_layer1.01091829
108MP0009384_cardiac_valve_regurgitation1.01028335
109MP0000750_abnormal_muscle_regeneration0.99730857
110MP0002163_abnormal_gland_morphology0.99600833
111MP0000516_abnormal_urinary_system0.99478748
112MP0005367_renal/urinary_system_phenotyp0.99478748
113MP0005058_abnormal_lysosome_morphology0.98679450
114MP0002822_catalepsy0.98315484
115MP0005076_abnormal_cell_differentiation0.97912210
116MP0000015_abnormal_ear_pigmentation0.97667827
117MP0005409_darkened_coat_color0.97224172
118MP0005375_adipose_tissue_phenotype0.96136186
119MP0005248_abnormal_Harderian_gland0.95315976
120MP0002133_abnormal_respiratory_system0.94706169
121MP0005388_respiratory_system_phenotype0.94706169
122MP0000681_abnormal_thyroid_gland0.93099309
123MP0002249_abnormal_larynx_morphology0.92985092
124MP0003938_abnormal_ear_development0.92481978
125MP0003436_decreased_susceptibility_to0.91578255
126MP0004883_abnormal_blood_vessel0.91073743
127MP0004510_myositis0.91025584
128MP0001915_intracranial_hemorrhage0.90933496
129MP0010352_gastrointestinal_tract_polyps0.90716688
130MP0002128_abnormal_blood_circulation0.90531673
131MP0010386_abnormal_urinary_bladder0.90055487
132MP0001346_abnormal_lacrimal_gland0.88919343
133MP0003303_peritoneal_inflammation0.88839059
134MP0003755_abnormal_palate_morphology0.88807507
135MP0002332_abnormal_exercise_endurance0.88159768
136MP0004084_abnormal_cardiac_muscle0.88051958
137MP0000579_abnormal_nail_morphology0.88038387
138MP0001963_abnormal_hearing_physiology0.87654912
139MP0003075_altered_response_to0.86706865
140MP0005620_abnormal_muscle_contractility0.86503725
141MP0003634_abnormal_glial_cell0.85596207
142MP0002638_abnormal_pupillary_reflex0.85488703
143MP0005499_abnormal_olfactory_system0.85298881
144MP0005394_taste/olfaction_phenotype0.85298881
145MP0003861_abnormal_nervous_system0.84844090
146MP0002277_abnormal_respiratory_mucosa0.83300137
147MP0002116_abnormal_craniofacial_bone0.83031311
148MP0005165_increased_susceptibility_to0.83016283
149MP0003448_altered_tumor_morphology0.82702688
150MP0001614_abnormal_blood_vessel0.82619172
151MP0005503_abnormal_tendon_morphology0.82594642
152MP0002933_joint_inflammation0.82468087
153MP0003045_fibrosis0.82455535
154MP0009053_abnormal_anal_canal0.81839273
155MP0001529_abnormal_vocalization0.80774438
156MP0008260_abnormal_autophagy0.79674173
157MP0000249_abnormal_blood_vessel0.79323822
158MP0004742_abnormal_vestibular_system0.79045522
159MP0002233_abnormal_nose_morphology0.77259133
160MP0000163_abnormal_cartilage_morphology0.77258463
161MP0004085_abnormal_heartbeat0.76336490
162MP0005369_muscle_phenotype0.76186061
163MP0001348_abnormal_lacrimal_gland0.75857684
164MP0000026_abnormal_inner_ear0.75198535
165MP0004484_altered_response_of0.74969925
166MP0002113_abnormal_skeleton_development0.74749278
167MP0002168_other_aberrant_phenotype0.74200567
168MP0002752_abnormal_somatic_nervous0.73483481
169MP0002269_muscular_atrophy0.73270442
170MP0003795_abnormal_bone_structure0.73251890
171MP0008789_abnormal_olfactory_epithelium0.73195128
172MP0002876_abnormal_thyroid_physiology0.72056090
173MP0000920_abnormal_myelination0.71629278
174MP0005670_abnormal_white_adipose0.71321723
175MP0002932_abnormal_joint_morphology0.71116083
176MP0000762_abnormal_tongue_morphology0.70400012
177MP0002069_abnormal_eating/drinking_beha0.70334850
178MP0002177_abnormal_outer_ear0.69049383
179MP0003633_abnormal_nervous_system0.68738454
180MP0003868_abnormal_feces_composition0.67454033
181MP0005551_abnormal_eye_electrophysiolog0.67403654
182MP0001905_abnormal_dopamine_level0.66288952
183MP0002234_abnormal_pharynx_morphology0.61503569
184MP0003631_nervous_system_phenotype0.61129309
185MP0002081_perinatal_lethality0.60095706
186MP0001849_ear_inflammation0.57868262
187MP0001986_abnormal_taste_sensitivity0.56993810

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.20241584
2Premature rupture of membranes (HP:0001788)5.82608890
3Protrusio acetabuli (HP:0003179)5.64793893
4Type 1 muscle fiber predominance (HP:0003803)4.66521979
5Febrile seizures (HP:0002373)4.47627303
6Aortic dissection (HP:0002647)4.05589594
7Focal seizures (HP:0007359)4.01850344
8Epileptic encephalopathy (HP:0200134)4.01253921
9Aortic aneurysm (HP:0004942)4.01145688
10Vascular tortuosity (HP:0004948)4.00626454
11Myokymia (HP:0002411)3.76859808
12Arterial tortuosity (HP:0005116)3.65672741
13Increased variability in muscle fiber diameter (HP:0003557)3.61416467
14Increased connective tissue (HP:0009025)3.57579236
15Spinal rigidity (HP:0003306)3.53496303
16Cerebral aneurysm (HP:0004944)3.35007781
17Abnormality of skeletal muscle fiber size (HP:0012084)3.31926915
18Progressive cerebellar ataxia (HP:0002073)3.29968014
19Bladder diverticulum (HP:0000015)3.26883627
20Fragile skin (HP:0001030)3.26733177
21Ankle contracture (HP:0006466)3.22458161
22Genetic anticipation (HP:0003743)3.20638935
23Atrophic scars (HP:0001075)3.20266383
24Large eyes (HP:0001090)3.18514954
25Spondylolisthesis (HP:0003302)3.15871527
26Slender build (HP:0001533)3.11908767
27Soft skin (HP:0000977)3.06672483
28Atonic seizures (HP:0010819)3.03734235
29Wormian bones (HP:0002645)3.01629037
30Hyperventilation (HP:0002883)2.98910726
31Mutism (HP:0002300)2.94813074
32Absent speech (HP:0001344)2.94736386
33Dilatation of the ascending aorta (HP:0005111)2.90698650
34Mitral valve prolapse (HP:0001634)2.89474954
35Visual hallucinations (HP:0002367)2.89396442
36Excessive salivation (HP:0003781)2.88224385
37Drooling (HP:0002307)2.88224385
38Broad-based gait (HP:0002136)2.86003388
39Obstructive sleep apnea (HP:0002870)2.85925955
40Broad metatarsal (HP:0001783)2.83115637
41Peritonitis (HP:0002586)2.81990148
42Mildly elevated creatine phosphokinase (HP:0008180)2.79320065
43Follicular hyperkeratosis (HP:0007502)2.77370138
44Abnormality of dentin (HP:0010299)2.77096932
45Blue sclerae (HP:0000592)2.76576433
46Neonatal short-limb short stature (HP:0008921)2.74362671
47Inappropriate behavior (HP:0000719)2.68068338
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.67195651
49Absence seizures (HP:0002121)2.62898947
50Ulnar bowing (HP:0003031)2.59033558
51Gaze-evoked nystagmus (HP:0000640)2.57916723
52Cervical subluxation (HP:0003308)2.57599378
53Poor eye contact (HP:0000817)2.57411487
54Muscle fiber inclusion bodies (HP:0100299)2.56467772
55Vertebral compression fractures (HP:0002953)2.53579720
56Distal lower limb amyotrophy (HP:0008944)2.53392758
57Generalized tonic-clonic seizures (HP:0002069)2.52980096
58Nemaline bodies (HP:0003798)2.49605796
59Round ear (HP:0100830)2.47551148
60Inability to walk (HP:0002540)2.45042069
61Joint laxity (HP:0001388)2.41938751
62Mitral regurgitation (HP:0001653)2.39038477
63Distal lower limb muscle weakness (HP:0009053)2.33989543
64Hyperextensible skin (HP:0000974)2.32662383
65Wide anterior fontanel (HP:0000260)2.32546735
66Aneurysm (HP:0002617)2.32027466
67Osteolytic defects of the phalanges of the hand (HP:0009771)2.31692955
68Osteolytic defects of the hand bones (HP:0009699)2.31692955
69Dialeptic seizures (HP:0011146)2.31177969
70Stereotypic behavior (HP:0000733)2.30550430
71Fetal akinesia sequence (HP:0001989)2.30334938
72Overgrowth (HP:0001548)2.29080269
73Urinary bladder sphincter dysfunction (HP:0002839)2.26051466
74Difficulty climbing stairs (HP:0003551)2.25969518
75Centrally nucleated skeletal muscle fibers (HP:0003687)2.25284688
76Bowel diverticulosis (HP:0005222)2.22617954
77Neoplasm of the adrenal cortex (HP:0100641)2.21714934
78Papilledema (HP:0001085)2.16780571
79Muscle fiber splitting (HP:0003555)2.16761653
80Protruding tongue (HP:0010808)2.15928529
81Mild short stature (HP:0003502)2.15298828
82Abnormality of incisor morphology (HP:0011063)2.14682162
83Disproportionate tall stature (HP:0001519)2.13353115
84Tented upper lip vermilion (HP:0010804)2.10213255
85Biconcave vertebral bodies (HP:0004586)2.09655021
86Hyperacusis (HP:0010780)2.09606049
87Widely spaced teeth (HP:0000687)2.09028197
88Impaired social interactions (HP:0000735)2.08563853
89Abnormal social behavior (HP:0012433)2.08563853
90Papillary thyroid carcinoma (HP:0002895)2.07705442
91Hepatoblastoma (HP:0002884)2.07652003
92Progressive inability to walk (HP:0002505)2.07391943
93Morphological abnormality of the middle ear (HP:0008609)2.07317193
94Asymmetric septal hypertrophy (HP:0001670)2.06126441
95Elbow flexion contracture (HP:0002987)2.04463488
96Septo-optic dysplasia (HP:0100842)2.01869119
97Upper limb amyotrophy (HP:0009129)1.98296031
98Distal upper limb amyotrophy (HP:0007149)1.98296031
99Limb dystonia (HP:0002451)1.97764838
100Wrist flexion contracture (HP:0001239)1.96847736
101Epileptiform EEG discharges (HP:0011182)1.94795370
102Aortic regurgitation (HP:0001659)1.94598841
103Abnormality of salivation (HP:0100755)1.94476822
104Oligodontia (HP:0000677)1.94412748
105Abnormality of the intervertebral disk (HP:0005108)1.94165198
106Bradycardia (HP:0001662)1.93850414
107Deeply set eye (HP:0000490)1.91755680
108Cutaneous finger syndactyly (HP:0010554)1.91473470
109Achilles tendon contracture (HP:0001771)1.91418884
110Camptodactyly of toe (HP:0001836)1.91383963
111Hypoplasia of the iris (HP:0007676)1.91170985
112Unilateral renal agenesis (HP:0000122)1.90790075
113Ankle clonus (HP:0011448)1.90571067
114Difficulty running (HP:0009046)1.90121003
115Action tremor (HP:0002345)1.90100631
116Hyporeflexia of lower limbs (HP:0002600)1.88547623
117Absent eyebrow (HP:0002223)1.88514975
118Aqueductal stenosis (HP:0002410)1.88124060
119Ectopia lentis (HP:0001083)1.87975350
120Ulnar deviation of the wrist (HP:0003049)1.87804755
121Hypoventilation (HP:0002791)1.86880045
122Neurofibrillary tangles (HP:0002185)1.85930631
123Supranuclear gaze palsy (HP:0000605)1.85842903
124Exercise-induced myalgia (HP:0003738)1.85572055
125Generalized amyotrophy (HP:0003700)1.85559044
126Narrow nasal bridge (HP:0000446)1.83544874
127Akinesia (HP:0002304)1.83399830
128Genu recurvatum (HP:0002816)1.82801577
129EEG with generalized epileptiform discharges (HP:0011198)1.81110812
130Persistence of primary teeth (HP:0006335)1.80697377
131Pachygyria (HP:0001302)1.80209142
132Generalized hypopigmentation of hair (HP:0011358)1.79898910
133Torticollis (HP:0000473)1.79854689
134Broad face (HP:0000283)1.79189120
135Lower limb amyotrophy (HP:0007210)1.78342416
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77308916
137Midline defect of the nose (HP:0004122)1.77009083
138Abnormal eating behavior (HP:0100738)1.76733821
139Natal tooth (HP:0000695)1.76697155
140Dysdiadochokinesis (HP:0002075)1.76526176
141Autism (HP:0000717)1.76508051
142Nonimmune hydrops fetalis (HP:0001790)1.76138017
143Mitral stenosis (HP:0001718)1.76002307
144Long toe (HP:0010511)1.75288810
145Aortic valve stenosis (HP:0001650)1.74946038
146Gastroesophageal reflux (HP:0002020)1.74484994
147Joint stiffness (HP:0001387)1.74360703
148Sleep apnea (HP:0010535)1.73466278
149Abnormality of the acetabulum (HP:0003170)1.72950497
150Abnormality of binocular vision (HP:0011514)1.72821751
151Diplopia (HP:0000651)1.72821751
152Premature skin wrinkling (HP:0100678)1.72801557
153Increased number of teeth (HP:0011069)1.71863919
154Complete atrioventricular canal defect (HP:0001674)1.71769810
155Coxa vara (HP:0002812)1.71695035
156Impaired vibration sensation in the lower limbs (HP:0002166)1.71393179
157Venous abnormality (HP:0002624)1.70792260
158Amblyopia (HP:0000646)1.70667441
159Short nail (HP:0001799)1.70511960
160Blue irides (HP:0000635)1.70394796
161Small hand (HP:0200055)1.69758478
162Turricephaly (HP:0000262)1.69634770
163Cerebral inclusion bodies (HP:0100314)1.69515997
164Macroglossia (HP:0000158)1.68664842
165Polyphagia (HP:0002591)1.68604904
166Joint contractures involving the joints of the feet (HP:0100492)1.66889271
167Flexion contracture of toe (HP:0005830)1.66889271
168Hypsarrhythmia (HP:0002521)1.65204463
169Conical tooth (HP:0000698)1.64872269
170Bowed forearm bones (HP:0003956)1.64506810
171Bowing of the arm (HP:0006488)1.64506810
172Intellectual disability, severe (HP:0010864)1.63467938
173Abnormal hair whorl (HP:0010721)1.63262484
174Scapular winging (HP:0003691)1.61562563
175Abnormality of the labia minora (HP:0012880)1.60269899
176Cutaneous syndactyly (HP:0012725)1.59898812
177Absent frontal sinuses (HP:0002688)1.59557476
178Nuclear cataract (HP:0100018)1.59397784
179Gait imbalance (HP:0002141)1.57874552
180Narrow palate (HP:0000189)1.57094308
181Limb-girdle muscle weakness (HP:0003325)1.57062277
182Absent septum pellucidum (HP:0001331)1.56680575
183Abnormality of the Achilles tendon (HP:0005109)1.56626459
184Lissencephaly (HP:0001339)1.56551801
185Shallow orbits (HP:0000586)1.56214895
186Dysmetria (HP:0001310)1.55938030
187Spinal canal stenosis (HP:0003416)1.52770561
188Truncal ataxia (HP:0002078)1.52604495
189Open mouth (HP:0000194)1.52339835
190Hemiparesis (HP:0001269)1.51546468
191Focal dystonia (HP:0004373)1.51477045
192Pointed chin (HP:0000307)1.51279194
193Smooth philtrum (HP:0000319)1.49012848
194Primary atrial arrhythmia (HP:0001692)1.48177653
195Prostate neoplasm (HP:0100787)1.47737131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.91234879
2NTRK33.47054516
3TTN3.43235963
4MAP2K73.30698133
5EPHA43.23813682
6CASK2.97715535
7TRIB32.95880843
8MAP3K42.94941496
9PDGFRA2.79352739
10SIK22.59513044
11TGFBR22.58953213
12TNIK2.58136705
13MAPK132.50365018
14RIPK12.49756129
15LATS22.40747529
16ERN12.35830765
17MAP3K92.24916207
18NTRK22.23863381
19MYLK2.20623989
20CDK82.07534415
21MINK12.00745978
22EPHB11.98658681
23DAPK21.94727636
24PTK21.88700869
25SIK31.85806401
26PLK21.79471118
27PAK61.75531336
28PRPF4B1.74651679
29SIK11.73694872
30MAP3K61.70477710
31MOS1.65494885
32MAP2K31.59635788
33ICK1.56498461
34MAP3K131.48938282
35MAP2K41.48453583
36NEK91.48121913
37PAK21.42945761
38CDC42BPA1.38518066
39MARK21.33971887
40KSR11.31740290
41SGK21.28202451
42AKT31.25813083
43IRAK31.25134302
44DYRK21.23149223
45PDGFRB1.22865692
46TIE11.21412279
47PIK3CG1.20718842
48TAOK11.20303337
49PRKD31.18897498
50SMG11.18098784
51EEF2K1.17095603
52MAP3K31.12819656
53RIPK41.11137180
54CDK51.09643848
55LATS11.07928072
56STK381.06545788
57MAP3K71.06512079
58EPHB21.06509490
59MAPK71.05696367
60CAMKK11.04656578
61TESK11.03309702
62CAMK10.99912857
63ERBB30.98819845
64DMPK0.98338584
65BMPR20.97469111
66LIMK10.95041772
67ZAP700.94555053
68PAK40.94276614
69DAPK10.93973880
70MAP3K120.92945088
71MUSK0.91829687
72PDPK10.89462124
73CAMK1G0.89106546
74MTOR0.88851689
75PTK2B0.88037305
76PRKCG0.87912279
77PHKG10.87817786
78PHKG20.87817786
79CSNK1G20.87630240
80ROCK20.87216241
81TRPM70.86615359
82ABL20.86533039
83INSRR0.86440193
84JAK10.86375124
85SGK30.86260231
86ARAF0.85891193
87SGK2230.83054081
88SGK4940.83054081
89CDK30.82902635
90FES0.80965102
91EIF2AK20.80119599
92PKN20.79800391
93CAMK2A0.73580342
94SGK10.72464833
95ROCK10.69825036
96TYK20.69010718
97CHEK20.68320565
98EPHA30.64998117
99OBSCN0.64786998
100DYRK1A0.64501181
101GSK3A0.64033527
102MAP3K10.63570315
103TAOK20.63095942
104GRK50.62565698
105STK38L0.61886912
106LMTK20.61581293
107PKN10.61256023
108PRKG20.60936168
109CAMK40.60533436
110MAPK40.60281114
111ERBB40.59817169
112GRK70.59783371
113STK110.58829830
114PRKD10.58287147
115FRK0.57193417
116NTRK10.56815646
117RET0.56552030
118PRKCH0.55914738
119PRKCE0.55489251
120RAF10.55068971
121KSR20.54158066
122RPS6KC10.54129694
123RPS6KL10.54129694
124CDK120.53737414
125CCNB10.52460798
126PRKCZ0.51691686
127CAMK2G0.50475648
128ADRBK10.50164433
129ZAK0.49724559
130PAK30.49019805
131FGFR20.48903627
132PTK60.48774705
133PDK10.48322336
134CDK180.48090884
135DDR20.47750175
136CSK0.46355333
137MAP3K110.45990703
138CDK150.45337243
139HIPK20.44662572
140RPS6KA20.44476855
141IRAK20.43262837
142KIT0.42675510
143MAPK100.42456329
144CDK11A0.42341952
145CAMKK20.42268227
146RPS6KA30.42012585
147FGFR40.41245696
148MET0.40919036
149ADRBK20.40773535
150CSNK1A1L0.39213997
151JAK30.38706515
152MKNK20.38434387
153TYRO30.36616612
154CDK140.36591758
155NUAK10.35499548
156PRKD20.35469126
157PIK3CA0.35071704
158GSK3B0.34650645
159PINK10.34594083
160PRKG10.34198479
161MAPK120.34153884
162PLK30.32795750
163PNCK0.32649309
164PRKAA10.32631817
165CAMK1D0.29845716

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.43988039
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.47826113
3Circadian entrainment_Homo sapiens_hsa047132.37030932
4Olfactory transduction_Homo sapiens_hsa047402.35885144
5Synaptic vesicle cycle_Homo sapiens_hsa047212.35292252
6Morphine addiction_Homo sapiens_hsa050322.34209021
7ECM-receptor interaction_Homo sapiens_hsa045122.33022336
8Glutamatergic synapse_Homo sapiens_hsa047242.23590614
9Focal adhesion_Homo sapiens_hsa045102.22716797
10GABAergic synapse_Homo sapiens_hsa047272.13143729
11Long-term potentiation_Homo sapiens_hsa047202.06139445
12Amphetamine addiction_Homo sapiens_hsa050311.88228571
13Dopaminergic synapse_Homo sapiens_hsa047281.79384800
14Axon guidance_Homo sapiens_hsa043601.77213138
15Cholinergic synapse_Homo sapiens_hsa047251.76969200
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.73523666
17Salivary secretion_Homo sapiens_hsa049701.70083386
18Taste transduction_Homo sapiens_hsa047421.63623157
19Serotonergic synapse_Homo sapiens_hsa047261.60792933
20Amoebiasis_Homo sapiens_hsa051461.58231617
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.53844820
22Insulin secretion_Homo sapiens_hsa049111.53578774
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52261003
24Oxytocin signaling pathway_Homo sapiens_hsa049211.52127195
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.50723557
26Long-term depression_Homo sapiens_hsa047301.49852086
27Renin secretion_Homo sapiens_hsa049241.47057807
28Prion diseases_Homo sapiens_hsa050201.45879109
29Cocaine addiction_Homo sapiens_hsa050301.43948954
30Glioma_Homo sapiens_hsa052141.42788151
31Calcium signaling pathway_Homo sapiens_hsa040201.41403431
32Proteoglycans in cancer_Homo sapiens_hsa052051.40513528
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40243151
34ErbB signaling pathway_Homo sapiens_hsa040121.34608530
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31446462
36cAMP signaling pathway_Homo sapiens_hsa040241.30550423
37GnRH signaling pathway_Homo sapiens_hsa049121.30377097
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29469099
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26275124
40Type II diabetes mellitus_Homo sapiens_hsa049301.24937787
41Gastric acid secretion_Homo sapiens_hsa049711.23658480
42Other glycan degradation_Homo sapiens_hsa005111.23084580
43Gap junction_Homo sapiens_hsa045401.17754997
44Notch signaling pathway_Homo sapiens_hsa043301.16989233
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14432912
46Osteoclast differentiation_Homo sapiens_hsa043801.13797469
47Endometrial cancer_Homo sapiens_hsa052131.13739492
48Malaria_Homo sapiens_hsa051441.09548633
49Protein digestion and absorption_Homo sapiens_hsa049741.09415509
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07827110
51Bladder cancer_Homo sapiens_hsa052191.06718812
52Estrogen signaling pathway_Homo sapiens_hsa049151.06609306
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06155044
54Phototransduction_Homo sapiens_hsa047441.05184409
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03932757
56Melanogenesis_Homo sapiens_hsa049161.03217798
57Acute myeloid leukemia_Homo sapiens_hsa052211.02324855
58Colorectal cancer_Homo sapiens_hsa052101.01281856
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00551491
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.99973208
61Adherens junction_Homo sapiens_hsa045200.99867912
62Platelet activation_Homo sapiens_hsa046110.99574583
63Small cell lung cancer_Homo sapiens_hsa052220.99414387
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97395635
65Endocytosis_Homo sapiens_hsa041440.96047157
66Wnt signaling pathway_Homo sapiens_hsa043100.95123653
67Melanoma_Homo sapiens_hsa052180.94767385
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93241799
69Ras signaling pathway_Homo sapiens_hsa040140.91095980
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91031903
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87607303
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.87141099
73MAPK signaling pathway_Homo sapiens_hsa040100.86970935
74Insulin signaling pathway_Homo sapiens_hsa049100.86181654
75Choline metabolism in cancer_Homo sapiens_hsa052310.86172895
76Pertussis_Homo sapiens_hsa051330.85894388
77Dilated cardiomyopathy_Homo sapiens_hsa054140.84616179
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.84272802
79Lysosome_Homo sapiens_hsa041420.83803826
80Pathways in cancer_Homo sapiens_hsa052000.83741094
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.82819369
82Toxoplasmosis_Homo sapiens_hsa051450.81783609
83Phagosome_Homo sapiens_hsa041450.81321715
84Renal cell carcinoma_Homo sapiens_hsa052110.81060981
85Rap1 signaling pathway_Homo sapiens_hsa040150.78982068
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77104424
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.76811324
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76001335
89TNF signaling pathway_Homo sapiens_hsa046680.75286218
90Non-small cell lung cancer_Homo sapiens_hsa052230.74489578
91Prolactin signaling pathway_Homo sapiens_hsa049170.73306415
92Pancreatic cancer_Homo sapiens_hsa052120.72431737
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71414587
94Circadian rhythm_Homo sapiens_hsa047100.70022578
95Ovarian steroidogenesis_Homo sapiens_hsa049130.69451627
96Collecting duct acid secretion_Homo sapiens_hsa049660.69435725
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68776800
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68758012
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68268884
100AMPK signaling pathway_Homo sapiens_hsa041520.67289334
101Dorso-ventral axis formation_Homo sapiens_hsa043200.67134605
102Insulin resistance_Homo sapiens_hsa049310.67062886
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66625462
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65933419
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65374643
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64815764
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64452252
108Salmonella infection_Homo sapiens_hsa051320.63322122
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.63066636
110Inositol phosphate metabolism_Homo sapiens_hsa005620.62761368
111B cell receptor signaling pathway_Homo sapiens_hsa046620.62328909
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.62167549
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61388904
114mTOR signaling pathway_Homo sapiens_hsa041500.61315955
115Basal cell carcinoma_Homo sapiens_hsa052170.61182302
116Tuberculosis_Homo sapiens_hsa051520.60919533
117Chemokine signaling pathway_Homo sapiens_hsa040620.60740401
118Complement and coagulation cascades_Homo sapiens_hsa046100.60549260
119Vibrio cholerae infection_Homo sapiens_hsa051100.60195988
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57379823
121Hippo signaling pathway_Homo sapiens_hsa043900.54324628
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53255172
123VEGF signaling pathway_Homo sapiens_hsa043700.52547953
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52377960
125Oocyte meiosis_Homo sapiens_hsa041140.50427228
126FoxO signaling pathway_Homo sapiens_hsa040680.50301751
127Type I diabetes mellitus_Homo sapiens_hsa049400.49834202
128Alcoholism_Homo sapiens_hsa050340.47774746
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47773990
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47609362
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47192499
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46444493
133Rheumatoid arthritis_Homo sapiens_hsa053230.45975322
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45936496
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45649415
136Chronic myeloid leukemia_Homo sapiens_hsa052200.45162009
137Hedgehog signaling pathway_Homo sapiens_hsa043400.44954778
138MicroRNAs in cancer_Homo sapiens_hsa052060.44287095
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43147899
140Prostate cancer_Homo sapiens_hsa052150.41732362

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