

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation by symbiont of host defense response (GO:0052509) | 5.68910212 |
| 2 | modulation by symbiont of host defense response (GO:0052031) | 5.68910212 |
| 3 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 5.68910212 |
| 4 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 5.68910212 |
| 5 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 5.68910212 |
| 6 | modulation by symbiont of host immune response (GO:0052553) | 5.68910212 |
| 7 | low-density lipoprotein particle clearance (GO:0034383) | 4.75496146 |
| 8 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.57287694 |
| 9 | regulation of cholesterol storage (GO:0010885) | 4.56361136 |
| 10 | regulation of interferon-beta biosynthetic process (GO:0045357) | 4.55721405 |
| 11 | macrophage activation involved in immune response (GO:0002281) | 4.55552852 |
| 12 | apoptotic cell clearance (GO:0043277) | 4.50026390 |
| 13 | response to peptidoglycan (GO:0032494) | 4.15694250 |
| 14 | neutrophil activation involved in immune response (GO:0002283) | 4.12056846 |
| 15 | negative regulation of erythrocyte differentiation (GO:0045647) | 4.08882691 |
| 16 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.03932331 |
| 17 | negative regulation of cell killing (GO:0031342) | 4.03932331 |
| 18 | positive regulation of interferon-alpha production (GO:0032727) | 3.97786654 |
| 19 | immunoglobulin mediated immune response (GO:0016064) | 3.96833478 |
| 20 | detection of other organism (GO:0098543) | 3.89308111 |
| 21 | regulation of gamma-delta T cell activation (GO:0046643) | 3.86882462 |
| 22 | positive thymic T cell selection (GO:0045059) | 3.82633196 |
| 23 | detection of bacterium (GO:0016045) | 3.77330898 |
| 24 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.75117428 |
| 25 | regulation of interferon-alpha production (GO:0032647) | 3.71169748 |
| 26 | response to host immune response (GO:0052572) | 3.66956417 |
| 27 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.66956417 |
| 28 | regulation of integrin activation (GO:0033623) | 3.61067882 |
| 29 | respiratory burst (GO:0045730) | 3.55096498 |
| 30 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.54221204 |
| 31 | regulation of leukocyte degranulation (GO:0043300) | 3.51262120 |
| 32 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.50284895 |
| 33 | B cell receptor signaling pathway (GO:0050853) | 3.49273801 |
| 34 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 3.43431451 |
| 35 | detection of external biotic stimulus (GO:0098581) | 3.42916280 |
| 36 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.40072678 |
| 37 | germinal center formation (GO:0002467) | 3.38657836 |
| 38 | negative regulation of interleukin-12 production (GO:0032695) | 3.36822989 |
| 39 | response to host (GO:0075136) | 3.35600858 |
| 40 | response to host defenses (GO:0052200) | 3.35600858 |
| 41 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.35600858 |
| 42 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.34417173 |
| 43 | hydrogen peroxide biosynthetic process (GO:0050665) | 3.28780386 |
| 44 | microglial cell activation (GO:0001774) | 3.24698421 |
| 45 | response to muramyl dipeptide (GO:0032495) | 3.24248653 |
| 46 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.23053038 |
| 47 | negative thymic T cell selection (GO:0045060) | 3.20192589 |
| 48 | cellular extravasation (GO:0045123) | 3.19783358 |
| 49 | negative regulation of granulocyte differentiation (GO:0030853) | 3.17771135 |
| 50 | T cell selection (GO:0045058) | 3.17248924 |
| 51 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.14847250 |
| 52 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.13234656 |
| 53 | positive T cell selection (GO:0043368) | 3.12185235 |
| 54 | detection of molecule of bacterial origin (GO:0032490) | 3.11948494 |
| 55 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.11865023 |
| 56 | regulation of mast cell activation (GO:0033003) | 3.10697177 |
| 57 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.09846050 |
| 58 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.09846050 |
| 59 | detection of biotic stimulus (GO:0009595) | 3.08951851 |
| 60 | macrophage activation (GO:0042116) | 3.08797236 |
| 61 | negative T cell selection (GO:0043383) | 3.07172810 |
| 62 | thymic T cell selection (GO:0045061) | 3.05218002 |
| 63 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.03602347 |
| 64 | positive regulation of interferon-beta production (GO:0032728) | 3.00383346 |
| 65 | pinocytosis (GO:0006907) | 2.99524950 |
| 66 | positive regulation of antigen processing and presentation (GO:0002579) | 2.98118510 |
| 67 | regulation of hypersensitivity (GO:0002883) | 2.97224254 |
| 68 | negative regulation of lipid storage (GO:0010888) | 2.97199427 |
| 69 | B cell mediated immunity (GO:0019724) | 2.95310370 |
| 70 | positive regulation of gamma-delta T cell activation (GO:0046645) | 2.94800948 |
| 71 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.94269887 |
| 72 | granulocyte activation (GO:0036230) | 2.94213764 |
| 73 | reactive oxygen species biosynthetic process (GO:1903409) | 2.93916272 |
| 74 | NIK/NF-kappaB signaling (GO:0038061) | 2.93321770 |
| 75 | mature B cell differentiation involved in immune response (GO:0002313) | 2.90691674 |
| 76 | positive regulation of lipid storage (GO:0010884) | 2.90637633 |
| 77 | cellular response to zinc ion (GO:0071294) | 2.90306161 |
| 78 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.90110520 |
| 79 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.90060717 |
| 80 | neutrophil activation (GO:0042119) | 2.89912724 |
| 81 | T-helper 1 type immune response (GO:0042088) | 2.89402876 |
| 82 | positive regulation of chemokine secretion (GO:0090197) | 2.86133270 |
| 83 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.84602758 |
| 84 | defense response to protozoan (GO:0042832) | 2.80859748 |
| 85 | leukocyte aggregation (GO:0070486) | 2.80841020 |
| 86 | natural killer cell mediated immunity (GO:0002228) | 2.80594194 |
| 87 | natural killer cell mediated cytotoxicity (GO:0042267) | 2.80594194 |
| 88 | myeloid dendritic cell activation (GO:0001773) | 2.77380785 |
| 89 | lipoprotein transport (GO:0042953) | 2.76963681 |
| 90 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.75953777 |
| 91 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.75808156 |
| 92 | positive regulation of macrophage cytokine production (GO:0060907) | 2.75790705 |
| 93 | myeloid cell activation involved in immune response (GO:0002275) | 2.75421087 |
| 94 | I-kappaB phosphorylation (GO:0007252) | 2.73619287 |
| 95 | N-acetylneuraminate metabolic process (GO:0006054) | 2.72953123 |
| 96 | regulation of regulated secretory pathway (GO:1903305) | 2.72421434 |
| 97 | amino sugar catabolic process (GO:0046348) | 2.70333417 |
| 98 | regulation of granulocyte differentiation (GO:0030852) | 2.69537357 |
| 99 | response to protozoan (GO:0001562) | 2.69315936 |
| 100 | regulation of mast cell degranulation (GO:0043304) | 2.69051573 |
| 101 | superoxide anion generation (GO:0042554) | 2.68249394 |
| 102 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.67619373 |
| 103 | negative regulation of macrophage derived foam cell differentiation (GO:0010745) | 2.67234688 |
| 104 | mannose metabolic process (GO:0006013) | 2.67221222 |
| 105 | positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081 | 2.66889431 |
| 106 | response to laminar fluid shear stress (GO:0034616) | 2.65801461 |
| 107 | leukotriene metabolic process (GO:0006691) | 2.65551463 |
| 108 | toxin transport (GO:1901998) | 2.65378186 |
| 109 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 2.65118124 |
| 110 | hyaluronan catabolic process (GO:0030214) | 2.64269790 |
| 111 | regulation of T cell tolerance induction (GO:0002664) | 2.63879975 |
| 112 | regulation of sequestering of triglyceride (GO:0010889) | 2.62986850 |
| 113 | positive regulation of B cell differentiation (GO:0045579) | 2.62447219 |
| 114 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 2.61783534 |
| 115 | positive regulation of mast cell activation (GO:0033005) | 2.60552655 |
| 116 | positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557) | 2.60414132 |
| 117 | positive regulation of leukocyte degranulation (GO:0043302) | 2.59708393 |
| 118 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.59340254 |
| 119 | basement membrane organization (GO:0071711) | 2.57717546 |
| 120 | myeloid leukocyte activation (GO:0002274) | 2.57688525 |
| 121 | myeloid dendritic cell differentiation (GO:0043011) | 2.57560370 |
| 122 | negative regulation of T cell mediated immunity (GO:0002710) | 2.56944301 |
| 123 | positive regulation of mast cell degranulation (GO:0043306) | 2.56616165 |
| 124 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.56616165 |
| 125 | adenosine receptor signaling pathway (GO:0001973) | 2.55924029 |
| 126 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 2.54821534 |
| 127 | vascular endothelial growth factor signaling pathway (GO:0038084) | 2.54418484 |
| 128 | positive regulation of cholesterol efflux (GO:0010875) | 2.54317500 |
| 129 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.53990620 |
| 130 | phagocytosis, recognition (GO:0006910) | 2.53505162 |
| 131 | leukocyte cell-cell adhesion (GO:0007159) | 2.52960009 |
| 132 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 2.52477287 |
| 133 | wound healing, spreading of epidermal cells (GO:0035313) | 2.50397704 |
| 134 | valine metabolic process (GO:0006573) | 2.49918572 |
| 135 | cytokine secretion (GO:0050663) | 2.49225316 |
| 136 | regulation of phagocytosis (GO:0050764) | 2.48451161 |
| 137 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.47279911 |
| 138 | plasma lipoprotein particle clearance (GO:0034381) | 2.43878254 |
| 139 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 2.43567520 |
| 140 | regulation of macrophage chemotaxis (GO:0010758) | 2.43032639 |
| 141 | positive regulation of sterol transport (GO:0032373) | 2.42949503 |
| 142 | positive regulation of cholesterol transport (GO:0032376) | 2.42949503 |
| 143 | regulation of antigen processing and presentation (GO:0002577) | 2.42761154 |
| 144 | negative regulation of interleukin-6 production (GO:0032715) | 2.41865857 |
| 145 | regulation of lipid storage (GO:0010883) | 2.41234049 |
| 146 | regulation of interferon-beta production (GO:0032648) | 2.41162419 |
| 147 | regulation of B cell differentiation (GO:0045577) | 2.40646647 |
| 148 | regulation of mononuclear cell migration (GO:0071675) | 2.39340121 |
| 149 | positive regulation of chemokine biosynthetic process (GO:0045080) | 2.39290135 |
| 150 | leukocyte mediated cytotoxicity (GO:0001909) | 2.39219954 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.33917511 |
| 2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.31513456 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.21864318 |
| 4 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 3.69646849 |
| 5 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.08884744 |
| 6 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.08283597 |
| 7 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.76071224 |
| 8 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.72528646 |
| 9 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.64517124 |
| 10 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.61887892 |
| 11 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.57944091 |
| 12 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.44065448 |
| 13 | * VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.38560965 |
| 14 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.35429770 |
| 15 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.28814277 |
| 16 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.24822132 |
| 17 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.21375346 |
| 18 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.10001241 |
| 19 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.04825182 |
| 20 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.02559244 |
| 21 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.92969993 |
| 22 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.92647360 |
| 23 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.89840226 |
| 24 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.89434988 |
| 25 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.78958114 |
| 26 | * PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.78187867 |
| 27 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.75389861 |
| 28 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.73727873 |
| 29 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.71530504 |
| 30 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.71358076 |
| 31 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.66544822 |
| 32 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.66186589 |
| 33 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.65888215 |
| 34 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.64954012 |
| 35 | SPI1_23127762_ChIP-Seq_K562_Human | 1.64190762 |
| 36 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.63288393 |
| 37 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.60065792 |
| 38 | MAF_26560356_Chip-Seq_TH2_Human | 1.59183253 |
| 39 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.57989184 |
| 40 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.57677048 |
| 41 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.57630395 |
| 42 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.51007530 |
| 43 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.49573940 |
| 44 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.48403080 |
| 45 | MAF_26560356_Chip-Seq_TH1_Human | 1.48289200 |
| 46 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.46436598 |
| 47 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.46168888 |
| 48 | MYC_22102868_ChIP-Seq_BL_Human | 1.45180572 |
| 49 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.43768767 |
| 50 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.42179921 |
| 51 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.42100399 |
| 52 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.41158863 |
| 53 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.41158863 |
| 54 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.41158863 |
| 55 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.39184979 |
| 56 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.38395045 |
| 57 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.37999875 |
| 58 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.37962367 |
| 59 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.37076799 |
| 60 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.35446877 |
| 61 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.35101861 |
| 62 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.30156575 |
| 63 | GATA1_22025678_ChIP-Seq_K562_Human | 1.29663319 |
| 64 | * TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.29495208 |
| 65 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.28911928 |
| 66 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.28534073 |
| 67 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.26540082 |
| 68 | * SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.26376950 |
| 69 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.26306109 |
| 70 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 1.25872068 |
| 71 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.25473020 |
| 72 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.24946815 |
| 73 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.24551961 |
| 74 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.22966538 |
| 75 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.22475744 |
| 76 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.21851962 |
| 77 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.21620087 |
| 78 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.20058603 |
| 79 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.19698364 |
| 80 | MYB_26560356_Chip-Seq_TH1_Human | 1.17482908 |
| 81 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.16290793 |
| 82 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.14883330 |
| 83 | MYB_26560356_Chip-Seq_TH2_Human | 1.14645947 |
| 84 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.13021246 |
| 85 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12516393 |
| 86 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.12140315 |
| 87 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.11739985 |
| 88 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.11085058 |
| 89 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.10861686 |
| 90 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.10728066 |
| 91 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.10540355 |
| 92 | UTX_26944678_Chip-Seq_JUKART_Human | 1.10321804 |
| 93 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.09609949 |
| 94 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.09170819 |
| 95 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.08728992 |
| 96 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.08469721 |
| 97 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.08166186 |
| 98 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.07207826 |
| 99 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.06012411 |
| 100 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.04276289 |
| 101 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.03779954 |
| 102 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.02630873 |
| 103 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.02523731 |
| 104 | KDM2B_26808549_Chip-Seq_K562_Human | 1.02246105 |
| 105 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.01686400 |
| 106 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.01461362 |
| 107 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01402428 |
| 108 | * RUNX_20019798_ChIP-Seq_JUKART_Human | 1.01198624 |
| 109 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.00987622 |
| 110 | * PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.00864855 |
| 111 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.00621377 |
| 112 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.99372112 |
| 113 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.98176557 |
| 114 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.97941516 |
| 115 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.97556537 |
| 116 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.96934856 |
| 117 | GATA1_19941826_ChIP-Seq_K562_Human | 0.95777854 |
| 118 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.95488691 |
| 119 | * GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94318930 |
| 120 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.93786791 |
| 121 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.93694716 |
| 122 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.93580050 |
| 123 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.93293521 |
| 124 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93143563 |
| 125 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.92797858 |
| 126 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.92137556 |
| 127 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 0.91969390 |
| 128 | P68_20966046_ChIP-Seq_HELA_Human | 0.91948093 |
| 129 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.91724056 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003191_abnormal_cellular_cholesterol | 3.27850200 |
| 2 | MP0005058_abnormal_lysosome_morphology | 3.26566987 |
| 3 | MP0003724_increased_susceptibility_to | 2.88232010 |
| 4 | MP0001835_abnormal_antigen_presentation | 2.86856756 |
| 5 | MP0003436_decreased_susceptibility_to | 2.78227022 |
| 6 | MP0003303_peritoneal_inflammation | 2.57498703 |
| 7 | MP0009840_abnormal_foam_cell | 2.41676144 |
| 8 | MP0002419_abnormal_innate_immunity | 2.34997131 |
| 9 | MP0005670_abnormal_white_adipose | 2.23795176 |
| 10 | MP0006082_CNS_inflammation | 2.18973278 |
| 11 | MP0003763_abnormal_thymus_physiology | 2.17869404 |
| 12 | MP0005167_abnormal_blood-brain_barrier | 2.15035277 |
| 13 | MP0003172_abnormal_lysosome_physiology | 2.13235171 |
| 14 | MP0004510_myositis | 2.09742419 |
| 15 | MP0009278_abnormal_bone_marrow | 2.08114872 |
| 16 | MP0009785_altered_susceptibility_to | 1.99271869 |
| 17 | MP0005025_abnormal_response_to | 1.99095374 |
| 18 | MP0005000_abnormal_immune_tolerance | 1.97087275 |
| 19 | MP0003705_abnormal_hypodermis_morpholog | 1.93415549 |
| 20 | MP0001790_abnormal_immune_system | 1.88367184 |
| 21 | MP0005387_immune_system_phenotype | 1.88367184 |
| 22 | MP0002148_abnormal_hypersensitivity_rea | 1.86355960 |
| 23 | MP0002452_abnormal_antigen_presenting | 1.83061136 |
| 24 | MP0000343_altered_response_to | 1.79703155 |
| 25 | MP0005451_abnormal_body_composition | 1.79025031 |
| 26 | MP0003566_abnormal_cell_adhesion | 1.73811879 |
| 27 | MP0003828_pulmonary_edema | 1.71808790 |
| 28 | MP0005464_abnormal_platelet_physiology | 1.67956982 |
| 29 | MP0001800_abnormal_humoral_immune | 1.66365036 |
| 30 | MP0003300_gastrointestinal_ulcer | 1.66296944 |
| 31 | MP0005360_urolithiasis | 1.64388304 |
| 32 | MP0008260_abnormal_autophagy | 1.62787656 |
| 33 | MP0001533_abnormal_skeleton_physiology | 1.62164266 |
| 34 | MP0002723_abnormal_immune_serum | 1.59007613 |
| 35 | MP0010368_abnormal_lymphatic_system | 1.58401140 |
| 36 | MP0000685_abnormal_immune_system | 1.55126521 |
| 37 | MP0004381_abnormal_hair_follicle | 1.54868661 |
| 38 | MP0003448_altered_tumor_morphology | 1.51864771 |
| 39 | MP0001819_abnormal_immune_cell | 1.48222849 |
| 40 | MP0002420_abnormal_adaptive_immunity | 1.46718785 |
| 41 | MP0008469_abnormal_protein_level | 1.46057141 |
| 42 | MP0004130_abnormal_muscle_cell | 1.44883980 |
| 43 | MP0003075_altered_response_to | 1.43305619 |
| 44 | MP0001545_abnormal_hematopoietic_system | 1.42365238 |
| 45 | MP0005397_hematopoietic_system_phenotyp | 1.42365238 |
| 46 | MP0001845_abnormal_inflammatory_respons | 1.42231844 |
| 47 | MP0005310_abnormal_salivary_gland | 1.41536993 |
| 48 | MP0004947_skin_inflammation | 1.41329026 |
| 49 | MP0002405_respiratory_system_inflammati | 1.39449999 |
| 50 | MP0005666_abnormal_adipose_tissue | 1.39358019 |
| 51 | MP0004185_abnormal_adipocyte_glucose | 1.39320134 |
| 52 | MP0001879_abnormal_lymphatic_vessel | 1.38990498 |
| 53 | MP0002138_abnormal_hepatobiliary_system | 1.37354202 |
| 54 | MP0001853_heart_inflammation | 1.33560795 |
| 55 | MP0002933_joint_inflammation | 1.27629219 |
| 56 | MP0004019_abnormal_vitamin_homeostasis | 1.24251400 |
| 57 | MP0004782_abnormal_surfactant_physiolog | 1.23859747 |
| 58 | MP0002998_abnormal_bone_remodeling | 1.22076246 |
| 59 | MP0005076_abnormal_cell_differentiation | 1.21929506 |
| 60 | MP0002136_abnormal_kidney_physiology | 1.20691316 |
| 61 | MP0009764_decreased_sensitivity_to | 1.20513204 |
| 62 | MP0001958_emphysema | 1.20470070 |
| 63 | MP0003186_abnormal_redox_activity | 1.19984981 |
| 64 | MP0005671_abnormal_response_to | 1.19445705 |
| 65 | MP0009643_abnormal_urine_homeostasis | 1.16627345 |
| 66 | MP0010352_gastrointestinal_tract_polyps | 1.15824926 |
| 67 | MP0008438_abnormal_cutaneous_collagen | 1.14121451 |
| 68 | MP0000703_abnormal_thymus_morphology | 1.12737223 |
| 69 | MP0003183_abnormal_peptide_metabolism | 1.11499329 |
| 70 | MP0010155_abnormal_intestine_physiology | 1.11482819 |
| 71 | MP0010329_abnormal_lipoprotein_level | 1.11385869 |
| 72 | MP0002166_altered_tumor_susceptibility | 1.10820102 |
| 73 | MP0002254_reproductive_system_inflammat | 1.10056935 |
| 74 | MP0000609_abnormal_liver_physiology | 1.09359850 |
| 75 | MP0000689_abnormal_spleen_morphology | 1.08812562 |
| 76 | MP0000716_abnormal_immune_system | 1.06125933 |
| 77 | MP0001851_eye_inflammation | 1.05883522 |
| 78 | MP0000249_abnormal_blood_vessel | 1.05766685 |
| 79 | MP0004808_abnormal_hematopoietic_stem | 1.05141812 |
| 80 | MP0008004_abnormal_stomach_pH | 1.04351191 |
| 81 | MP0005319_abnormal_enzyme/_coenzyme | 1.04077779 |
| 82 | MP0003690_abnormal_glial_cell | 1.03821663 |
| 83 | MP0004883_abnormal_blood_vessel | 1.03050579 |
| 84 | MP0000858_altered_metastatic_potential | 1.02441104 |
| 85 | MP0004272_abnormal_basement_membrane | 1.02167365 |
| 86 | MP0002006_tumorigenesis | 0.99139891 |
| 87 | MP0005375_adipose_tissue_phenotype | 0.98651833 |
| 88 | MP0009115_abnormal_fat_cell | 0.98624841 |
| 89 | MP0009763_increased_sensitivity_to | 0.98207629 |
| 90 | MP0002332_abnormal_exercise_endurance | 0.95909869 |
| 91 | MP0000465_gastrointestinal_hemorrhage | 0.95823537 |
| 92 | MP0009333_abnormal_splenocyte_physiolog | 0.95213030 |
| 93 | MP0001849_ear_inflammation | 0.95085135 |
| 94 | MP0000371_diluted_coat_color | 0.94325182 |
| 95 | MP0002429_abnormal_blood_cell | 0.93679068 |
| 96 | MP0005166_decreased_susceptibility_to | 0.93622464 |
| 97 | MP0003866_abnormal_defecation | 0.93215236 |
| 98 | MP0002398_abnormal_bone_marrow | 0.92154864 |
| 99 | MP0001756_abnormal_urination | 0.91119617 |
| 100 | MP0005023_abnormal_wound_healing | 0.90657751 |
| 101 | MP0005164_abnormal_response_to | 0.89900403 |
| 102 | MP0001873_stomach_inflammation | 0.89158483 |
| 103 | MP0002722_abnormal_immune_system | 0.88518440 |
| 104 | MP0002009_preneoplasia | 0.87945970 |
| 105 | MP0003453_abnormal_keratinocyte_physiol | 0.87022713 |
| 106 | MP0005332_abnormal_amino_acid | 0.85698022 |
| 107 | MP0002971_abnormal_brown_adipose | 0.85466820 |
| 108 | MP0000767_abnormal_smooth_muscle | 0.85073842 |
| 109 | MP0010307_abnormal_tumor_latency | 0.83666142 |
| 110 | MP0002132_abnormal_respiratory_system | 0.82111500 |
| 111 | MP0000604_amyloidosis | 0.82023380 |
| 112 | MP0000598_abnormal_liver_morphology | 0.81850504 |
| 113 | MP0003091_abnormal_cell_migration | 0.81009952 |
| 114 | MP0002139_abnormal_hepatobiliary_system | 0.80779227 |
| 115 | MP0002396_abnormal_hematopoietic_system | 0.80755871 |
| 116 | MP0005409_darkened_coat_color | 0.78066963 |
| 117 | MP0005390_skeleton_phenotype | 0.75687446 |
| 118 | MP0003795_abnormal_bone_structure | 0.73979851 |
| 119 | MP0001663_abnormal_digestive_system | 0.71443078 |
| 120 | MP0003279_aneurysm | 0.70373672 |
| 121 | MP0005075_abnormal_melanosome_morpholog | 0.69496713 |
| 122 | MP0003806_abnormal_nucleotide_metabolis | 0.68953057 |
| 123 | MP0002877_abnormal_melanocyte_morpholog | 0.67796082 |
| 124 | MP0005165_increased_susceptibility_to | 0.65910563 |
| 125 | MP0000490_abnormal_crypts_of | 0.63659399 |
| 126 | MP0001915_intracranial_hemorrhage | 0.62587048 |
| 127 | MP0003656_abnormal_erythrocyte_physiolo | 0.59282474 |
| 128 | MP0003045_fibrosis | 0.57628884 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 5.53611529 |
| 2 | Eczematoid dermatitis (HP:0000976) | 5.30667944 |
| 3 | Recurrent gram-negative bacterial infections (HP:0005420) | 5.13289115 |
| 4 | Recurrent bacterial skin infections (HP:0005406) | 4.96190644 |
| 5 | Systemic lupus erythematosus (HP:0002725) | 4.76186611 |
| 6 | Vacuolated lymphocytes (HP:0001922) | 4.66744576 |
| 7 | Abnormality of macrophages (HP:0004311) | 4.41656706 |
| 8 | Increased cerebral lipofuscin (HP:0011813) | 4.01939240 |
| 9 | Dysostosis multiplex (HP:0000943) | 3.75809558 |
| 10 | Autoimmune thrombocytopenia (HP:0001973) | 3.63883776 |
| 11 | Hematochezia (HP:0002573) | 3.53342073 |
| 12 | Axonal loss (HP:0003447) | 3.46883470 |
| 13 | Abnormality of glycolipid metabolism (HP:0010969) | 3.39445099 |
| 14 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.39445099 |
| 15 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.39445099 |
| 16 | Meningitis (HP:0001287) | 3.37076352 |
| 17 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.36958036 |
| 18 | Gingivitis (HP:0000230) | 3.28424596 |
| 19 | Glomerulonephritis (HP:0000099) | 3.24041193 |
| 20 | Myocardial infarction (HP:0001658) | 3.19248872 |
| 21 | Increased IgE level (HP:0003212) | 3.15479800 |
| 22 | Mucopolysacchariduria (HP:0008155) | 3.13939687 |
| 23 | Urinary glycosaminoglycan excretion (HP:0003541) | 3.13939687 |
| 24 | Cerebral aneurysm (HP:0004944) | 3.08793052 |
| 25 | Panhypogammaglobulinemia (HP:0003139) | 3.05773666 |
| 26 | Agammaglobulinemia (HP:0004432) | 3.04085071 |
| 27 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.96789365 |
| 28 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.96789365 |
| 29 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.96789365 |
| 30 | Recurrent skin infections (HP:0001581) | 2.93353699 |
| 31 | Interstitial pulmonary disease (HP:0006530) | 2.93184799 |
| 32 | Mediastinal lymphadenopathy (HP:0100721) | 2.87716234 |
| 33 | Pustule (HP:0200039) | 2.87141428 |
| 34 | Joint hemorrhage (HP:0005261) | 2.85405925 |
| 35 | Esophageal varix (HP:0002040) | 2.84556959 |
| 36 | Spontaneous hematomas (HP:0007420) | 2.84282902 |
| 37 | Recurrent fungal infections (HP:0002841) | 2.73685395 |
| 38 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.71654181 |
| 39 | Complement deficiency (HP:0004431) | 2.67510263 |
| 40 | Myositis (HP:0100614) | 2.62925878 |
| 41 | Abnormality of complement system (HP:0005339) | 2.60719628 |
| 42 | Retrobulbar optic neuritis (HP:0100654) | 2.56086155 |
| 43 | Optic neuritis (HP:0100653) | 2.56086155 |
| 44 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.55129937 |
| 45 | Nephritis (HP:0000123) | 2.53435138 |
| 46 | Cellulitis (HP:0100658) | 2.52496153 |
| 47 | Colitis (HP:0002583) | 2.52160581 |
| 48 | Abnormality of the nasal mucosa (HP:0000433) | 2.51733202 |
| 49 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.49491074 |
| 50 | Prolonged bleeding time (HP:0003010) | 2.49328422 |
| 51 | Orchitis (HP:0100796) | 2.46688823 |
| 52 | Periodontitis (HP:0000704) | 2.43699974 |
| 53 | Purpura (HP:0000979) | 2.43562587 |
| 54 | Loss of speech (HP:0002371) | 2.43552127 |
| 55 | Polycythemia (HP:0001901) | 2.40831098 |
| 56 | Nausea (HP:0002018) | 2.39176849 |
| 57 | Disinhibition (HP:0000734) | 2.36635500 |
| 58 | Hemoptysis (HP:0002105) | 2.33676327 |
| 59 | Tetraparesis (HP:0002273) | 2.31075292 |
| 60 | Obstructive lung disease (HP:0006536) | 2.29096162 |
| 61 | Chronic obstructive pulmonary disease (HP:0006510) | 2.29096162 |
| 62 | Pathologic fracture (HP:0002756) | 2.26557766 |
| 63 | Recurrent viral infections (HP:0004429) | 2.25019791 |
| 64 | Pulmonary infiltrates (HP:0002113) | 2.23979663 |
| 65 | Gastrointestinal stroma tumor (HP:0100723) | 2.23786818 |
| 66 | Asymmetric septal hypertrophy (HP:0001670) | 2.22576338 |
| 67 | Broad face (HP:0000283) | 2.22335384 |
| 68 | Encephalitis (HP:0002383) | 2.22194527 |
| 69 | Granulocytopenia (HP:0001913) | 2.18763498 |
| 70 | Thoracic kyphosis (HP:0002942) | 2.15343892 |
| 71 | Upper motor neuron abnormality (HP:0002127) | 2.15115690 |
| 72 | T lymphocytopenia (HP:0005403) | 2.15108529 |
| 73 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.14644718 |
| 74 | Osteolytic defects of the hand bones (HP:0009699) | 2.14644718 |
| 75 | Urticaria (HP:0001025) | 2.14172317 |
| 76 | Polygenic inheritance (HP:0010982) | 2.11465348 |
| 77 | Neuronal loss in central nervous system (HP:0002529) | 2.10977010 |
| 78 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.10097058 |
| 79 | Conjunctival telangiectasia (HP:0000524) | 2.10066626 |
| 80 | Papilloma (HP:0012740) | 2.09941583 |
| 81 | Verrucae (HP:0200043) | 2.09941583 |
| 82 | Hemorrhage of the eye (HP:0011885) | 2.06724470 |
| 83 | Hepatosplenomegaly (HP:0001433) | 2.05766804 |
| 84 | Chest pain (HP:0100749) | 2.05333773 |
| 85 | Mutism (HP:0002300) | 2.04847695 |
| 86 | Gastrointestinal infarctions (HP:0005244) | 2.04624843 |
| 87 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.04582636 |
| 88 | Restrictive lung disease (HP:0002091) | 2.04465804 |
| 89 | Osteomyelitis (HP:0002754) | 2.03660048 |
| 90 | Leukocytosis (HP:0001974) | 2.02988759 |
| 91 | IgM deficiency (HP:0002850) | 2.01844924 |
| 92 | Spondylolisthesis (HP:0003302) | 2.01163737 |
| 93 | Hyperglycinuria (HP:0003108) | 2.01124941 |
| 94 | Petechiae (HP:0000967) | 2.00159722 |
| 95 | Abnormality of B cell number (HP:0010975) | 2.00144384 |
| 96 | Hydroxyprolinuria (HP:0003080) | 1.98845242 |
| 97 | Abnormality of proline metabolism (HP:0010907) | 1.98845242 |
| 98 | Agnosia (HP:0010524) | 1.98706353 |
| 99 | Sepsis (HP:0100806) | 1.97552862 |
| 100 | Pulmonary embolism (HP:0002204) | 1.96704046 |
| 101 | Abnormality of T cell number (HP:0011839) | 1.96108460 |
| 102 | Amyloidosis (HP:0011034) | 1.94315329 |
| 103 | Multiple enchondromatosis (HP:0005701) | 1.94134236 |
| 104 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 1.94071897 |
| 105 | Abnormality of purine metabolism (HP:0004352) | 1.93699759 |
| 106 | Bone pain (HP:0002653) | 1.93240391 |
| 107 | Hand muscle atrophy (HP:0009130) | 1.92899968 |
| 108 | Viral hepatitis (HP:0006562) | 1.92777658 |
| 109 | Lymphopenia (HP:0001888) | 1.92758964 |
| 110 | Peripheral demyelination (HP:0011096) | 1.92669775 |
| 111 | B lymphocytopenia (HP:0010976) | 1.91566913 |
| 112 | Keratoconjunctivitis sicca (HP:0001097) | 1.90178721 |
| 113 | Inflammation of the large intestine (HP:0002037) | 1.89624342 |
| 114 | Autoimmune hemolytic anemia (HP:0001890) | 1.89221092 |
| 115 | Menorrhagia (HP:0000132) | 1.86890245 |
| 116 | Xanthomatosis (HP:0000991) | 1.85894036 |
| 117 | Increased serum ferritin (HP:0003281) | 1.84633407 |
| 118 | Vasculitis (HP:0002633) | 1.81909015 |
| 119 | Gastrointestinal inflammation (HP:0004386) | 1.78383020 |
| 120 | Arterial thrombosis (HP:0004420) | 1.78242366 |
| 121 | Thick nail (HP:0001805) | 1.77334772 |
| 122 | Mucosal telangiectasiae (HP:0100579) | 1.77193834 |
| 123 | Basal ganglia calcification (HP:0002135) | 1.75813450 |
| 124 | Abnormal platelet function (HP:0011869) | 1.73437360 |
| 125 | Impaired platelet aggregation (HP:0003540) | 1.73437360 |
| 126 | Nasal polyposis (HP:0100582) | 1.73156806 |
| 127 | Epistaxis (HP:0000421) | 1.72400742 |
| 128 | Increased CSF protein (HP:0002922) | 1.71715764 |
| 129 | Gingival bleeding (HP:0000225) | 1.71663298 |
| 130 | Progressive visual loss (HP:0000529) | 1.70798398 |
| 131 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.70187485 |
| 132 | Recurrent cutaneous fungal infections (HP:0011370) | 1.70187485 |
| 133 | Stomatitis (HP:0010280) | 1.68991347 |
| 134 | Metaphyseal cupping (HP:0003021) | 1.68190120 |
| 135 | J-shaped sella turcica (HP:0002680) | 1.67990672 |
| 136 | Hypertriglyceridemia (HP:0002155) | 1.67851777 |
| 137 | Abnormality of iron homeostasis (HP:0011031) | 1.66580702 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TGFBR2 | 3.75447127 |
| 2 | ERN1 | 3.42162725 |
| 3 | KDR | 3.14352421 |
| 4 | PRPF4B | 3.07149832 |
| 5 | MAP4K1 | 3.02366972 |
| 6 | TIE1 | 2.90969896 |
| 7 | IRAK3 | 2.56785682 |
| 8 | TYK2 | 2.54093267 |
| 9 | CAMK1D | 2.39970681 |
| 10 | BLK | 2.30629102 |
| 11 | TBK1 | 2.26783819 |
| 12 | TRIB3 | 2.21940612 |
| 13 | RIPK4 | 2.15387094 |
| 14 | MAP3K14 | 2.09025989 |
| 15 | STK10 | 2.00306249 |
| 16 | CDK12 | 1.97412213 |
| 17 | KIT | 1.86620758 |
| 18 | IRAK4 | 1.84416524 |
| 19 | CSK | 1.80537043 |
| 20 | MAP2K3 | 1.79872880 |
| 21 | RIPK1 | 1.76921749 |
| 22 | CSF1R | 1.72922788 |
| 23 | JAK1 | 1.66797313 |
| 24 | MST1R | 1.61248041 |
| 25 | SMG1 | 1.58929103 |
| 26 | TNK2 | 1.57894843 |
| 27 | JAK3 | 1.52030519 |
| 28 | TTN | 1.43534011 |
| 29 | PKN2 | 1.36975833 |
| 30 | CAMK1G | 1.35519656 |
| 31 | MATK | 1.34714756 |
| 32 | IKBKB | 1.32286152 |
| 33 | EPHB1 | 1.30527460 |
| 34 | MAP3K3 | 1.27682340 |
| 35 | PAK4 | 1.24984935 |
| 36 | CDC42BPA | 1.21181789 |
| 37 | MARK2 | 1.20249192 |
| 38 | MAP3K11 | 1.20134416 |
| 39 | ICK | 1.18412585 |
| 40 | ZAP70 | 1.16203655 |
| 41 | MAP3K10 | 1.15827159 |
| 42 | MAP3K1 | 1.15644872 |
| 43 | GRK6 | 1.12588525 |
| 44 | PTK6 | 1.10605483 |
| 45 | HCK | 1.09736346 |
| 46 | FGR | 1.09637593 |
| 47 | BMX | 1.09215155 |
| 48 | TAOK1 | 1.08964295 |
| 49 | ITK | 1.08277885 |
| 50 | LRRK2 | 1.07765002 |
| 51 | JAK2 | 1.07412290 |
| 52 | IKBKE | 1.05102431 |
| 53 | MAP3K7 | 1.02278023 |
| 54 | ABL2 | 0.98813011 |
| 55 | PIM1 | 0.96967857 |
| 56 | MARK3 | 0.95370489 |
| 57 | FGFR4 | 0.92052362 |
| 58 | PRKD2 | 0.89939260 |
| 59 | TAOK2 | 0.86901780 |
| 60 | PDK2 | 0.86296632 |
| 61 | BCKDK | 0.83037605 |
| 62 | RPS6KA4 | 0.78909321 |
| 63 | CHUK | 0.78607789 |
| 64 | TESK2 | 0.78255995 |
| 65 | TXK | 0.76579502 |
| 66 | GRK1 | 0.76308110 |
| 67 | EPHA2 | 0.74800253 |
| 68 | TAOK3 | 0.72634845 |
| 69 | CDK6 | 0.71658121 |
| 70 | LCK | 0.71429435 |
| 71 | BTK | 0.71248395 |
| 72 | SIK1 | 0.71037295 |
| 73 | SIK2 | 0.70295102 |
| 74 | LYN | 0.70225727 |
| 75 | NEK9 | 0.68998451 |
| 76 | EEF2K | 0.68539639 |
| 77 | SYK | 0.68043982 |
| 78 | EGFR | 0.67740485 |
| 79 | NME2 | 0.67269579 |
| 80 | PRKG2 | 0.67043624 |
| 81 | MAPK11 | 0.66125419 |
| 82 | MAP3K13 | 0.66073821 |
| 83 | CAMKK2 | 0.65706306 |
| 84 | SIK3 | 0.65592796 |
| 85 | FGFR3 | 0.65039096 |
| 86 | HIPK2 | 0.63641737 |
| 87 | RPS6KA2 | 0.63271692 |
| 88 | SCYL2 | 0.63262606 |
| 89 | ARAF | 0.63195992 |
| 90 | NLK | 0.61511975 |
| 91 | TGFBR1 | 0.60853251 |
| 92 | FLT3 | 0.60069806 |
| 93 | PIM2 | 0.60061589 |
| 94 | IRAK2 | 0.59749168 |
| 95 | GSK3A | 0.59570029 |
| 96 | BMPR2 | 0.59485349 |
| 97 | GRK7 | 0.57524664 |
| 98 | CDK4 | 0.57033968 |
| 99 | MET | 0.55924807 |
| 100 | STK4 | 0.55922365 |
| 101 | PDPK1 | 0.55731867 |
| 102 | KSR2 | 0.55346814 |
| 103 | CAMKK1 | 0.55166151 |
| 104 | MAPK15 | 0.52212294 |
| 105 | PBK | 0.52158047 |
| 106 | RPS6KA6 | 0.51975603 |
| 107 | ABL1 | 0.51225334 |
| 108 | PIK3CG | 0.49662507 |
| 109 | TRPM7 | 0.49001640 |
| 110 | PRKCD | 0.48459724 |
| 111 | MAP3K8 | 0.47785298 |
| 112 | MAPK12 | 0.47619333 |
| 113 | RPS6KL1 | 0.47459978 |
| 114 | RPS6KC1 | 0.47459978 |
| 115 | PRKAA2 | 0.46914943 |
| 116 | PDGFRA | 0.46345998 |
| 117 | FYN | 0.46309432 |
| 118 | PDK1 | 0.45035054 |
| 119 | CDK9 | 0.43727118 |
| 120 | IRAK1 | 0.43504600 |
| 121 | MOS | 0.43390283 |
| 122 | FES | 0.43253449 |
| 123 | MAP3K2 | 0.43191922 |
| 124 | TEC | 0.42148223 |
| 125 | MAPK7 | 0.39969565 |
| 126 | CLK1 | 0.39767580 |
| 127 | IGF1R | 0.39426077 |
| 128 | MAP2K2 | 0.36851342 |
| 129 | MTOR | 0.35036819 |
| 130 | MAP3K6 | 0.33873285 |
| 131 | MAPK4 | 0.32594307 |
| 132 | CAMK4 | 0.32206962 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 3.89838545 |
| 2 | Other glycan degradation_Homo sapiens_hsa00511 | 2.91829990 |
| 3 | Leishmaniasis_Homo sapiens_hsa05140 | 2.77705886 |
| 4 | Lysosome_Homo sapiens_hsa04142 | 2.70735146 |
| 5 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.66857381 |
| 6 | Allograft rejection_Homo sapiens_hsa05330 | 2.32847964 |
| 7 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.15701941 |
| 8 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.13055132 |
| 9 | Malaria_Homo sapiens_hsa05144 | 2.06756358 |
| 10 | Legionellosis_Homo sapiens_hsa05134 | 2.06139854 |
| 11 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.05229379 |
| 12 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.98726093 |
| 13 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.98328536 |
| 14 | Pertussis_Homo sapiens_hsa05133 | 1.96932388 |
| 15 | Tuberculosis_Homo sapiens_hsa05152 | 1.88625130 |
| 16 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.79493533 |
| 17 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.62609540 |
| 18 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.62391037 |
| 19 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.60715653 |
| 20 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.57060675 |
| 21 | Phagosome_Homo sapiens_hsa04145 | 1.40312080 |
| 22 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.38576633 |
| 23 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.36541926 |
| 24 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.34566695 |
| 25 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.32550528 |
| 26 | Influenza A_Homo sapiens_hsa05164 | 1.30639697 |
| 27 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.29293509 |
| 28 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.26894810 |
| 29 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.26707382 |
| 30 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.25875739 |
| 31 | Measles_Homo sapiens_hsa05162 | 1.24388870 |
| 32 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.23681244 |
| 33 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.22075181 |
| 34 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.20583727 |
| 35 | Salmonella infection_Homo sapiens_hsa05132 | 1.18705905 |
| 36 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.18187345 |
| 37 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.15596831 |
| 38 | Apoptosis_Homo sapiens_hsa04210 | 1.12466413 |
| 39 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.11556029 |
| 40 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.10667203 |
| 41 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.09531942 |
| 42 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.08675672 |
| 43 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.05688295 |
| 44 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.04853159 |
| 45 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.04000503 |
| 46 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.03498358 |
| 47 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.01145728 |
| 48 | Shigellosis_Homo sapiens_hsa05131 | 0.98269279 |
| 49 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.93170078 |
| 50 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.92924866 |
| 51 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.91815695 |
| 52 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.91218366 |
| 53 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.89866854 |
| 54 | Amoebiasis_Homo sapiens_hsa05146 | 0.88548536 |
| 55 | Viral myocarditis_Homo sapiens_hsa05416 | 0.87136370 |
| 56 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.85220381 |
| 57 | Bladder cancer_Homo sapiens_hsa05219 | 0.84462018 |
| 58 | Hepatitis C_Homo sapiens_hsa05160 | 0.83689338 |
| 59 | Insulin resistance_Homo sapiens_hsa04931 | 0.81592683 |
| 60 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.80657715 |
| 61 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.80536284 |
| 62 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.80347647 |
| 63 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.79882772 |
| 64 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.78840196 |
| 65 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.78638644 |
| 66 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.78305605 |
| 67 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.78208694 |
| 68 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.77599552 |
| 69 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.77035908 |
| 70 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.76468202 |
| 71 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.75725286 |
| 72 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.75175896 |
| 73 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.74458899 |
| 74 | Peroxisome_Homo sapiens_hsa04146 | 0.74228869 |
| 75 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.73595043 |
| 76 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.73323522 |
| 77 | ABC transporters_Homo sapiens_hsa02010 | 0.72730290 |
| 78 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.72404393 |
| 79 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.72215749 |
| 80 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.72159219 |
| 81 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.71917659 |
| 82 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.70517846 |
| 83 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.70445638 |
| 84 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.69889456 |
| 85 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.69041952 |
| 86 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.68310134 |
| 87 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.66583262 |
| 88 | HTLV-I infection_Homo sapiens_hsa05166 | 0.65821902 |
| 89 | Lysine degradation_Homo sapiens_hsa00310 | 0.64704631 |
| 90 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.64446885 |
| 91 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.63708418 |
| 92 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.63522458 |
| 93 | Platelet activation_Homo sapiens_hsa04611 | 0.62402088 |
| 94 | Hepatitis B_Homo sapiens_hsa05161 | 0.61618549 |
| 95 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.61492454 |
| 96 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.61288997 |
| 97 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.61071845 |
| 98 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.60997252 |
| 99 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.59769396 |
| 100 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.58897888 |
| 101 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.57811855 |
| 102 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.57402888 |
| 103 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.56726571 |
| 104 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.55303386 |
| 105 | Carbon metabolism_Homo sapiens_hsa01200 | 0.55277801 |
| 106 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.55098784 |
| 107 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.54656946 |
| 108 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.54442946 |
| 109 | Endocytosis_Homo sapiens_hsa04144 | 0.53733421 |
| 110 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.52385978 |
| 111 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.52071567 |
| 112 | Mineral absorption_Homo sapiens_hsa04978 | 0.51820867 |
| 113 | Adherens junction_Homo sapiens_hsa04520 | 0.50964292 |
| 114 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.50127865 |
| 115 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.49142842 |
| 116 | Galactose metabolism_Homo sapiens_hsa00052 | 0.48278601 |
| 117 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.48243878 |
| 118 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.48191654 |
| 119 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.46598434 |
| 120 | Colorectal cancer_Homo sapiens_hsa05210 | 0.46300344 |
| 121 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.46224101 |
| 122 | Focal adhesion_Homo sapiens_hsa04510 | 0.46054170 |
| 123 | Endometrial cancer_Homo sapiens_hsa05213 | 0.45984671 |
| 124 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.45047018 |
| 125 | Prion diseases_Homo sapiens_hsa05020 | 0.43124780 |
| 126 | Asthma_Homo sapiens_hsa05310 | 0.42359520 |
| 127 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.42323186 |
| 128 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.41838501 |
| 129 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.41331769 |
| 130 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.40562092 |
| 131 | Prostate cancer_Homo sapiens_hsa05215 | 0.40006123 |
| 132 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.39756011 |
| 133 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.39390760 |
| 134 | Glioma_Homo sapiens_hsa05214 | 0.39124995 |
| 135 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.35308044 |
| 136 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.34444725 |

