SHANK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20388829
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.03310965
3locomotory exploration behavior (GO:0035641)5.93287303
4synaptic vesicle maturation (GO:0016188)5.84426167
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56812263
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.56416776
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.52280258
8* vocalization behavior (GO:0071625)5.48867190
9synaptic vesicle exocytosis (GO:0016079)5.45906617
10glutamate secretion (GO:0014047)5.34662134
11regulation of glutamate receptor signaling pathway (GO:1900449)5.10121240
12regulation of synaptic vesicle exocytosis (GO:2000300)5.07698724
13protein localization to synapse (GO:0035418)4.97222901
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.90102799
15neurotransmitter-gated ion channel clustering (GO:0072578)4.61290054
16neurotransmitter secretion (GO:0007269)4.54998592
17exploration behavior (GO:0035640)4.53143392
18regulation of synaptic vesicle transport (GO:1902803)4.52256687
19glutamate receptor signaling pathway (GO:0007215)4.48640542
20synaptic transmission, glutamatergic (GO:0035249)4.48321827
21neuron cell-cell adhesion (GO:0007158)4.39102324
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.36968142
23regulation of neuronal synaptic plasticity (GO:0048168)4.35605851
24layer formation in cerebral cortex (GO:0021819)4.31098770
25positive regulation of synapse maturation (GO:0090129)4.27734613
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.27225198
27neuronal action potential propagation (GO:0019227)4.22631672
28cellular potassium ion homeostasis (GO:0030007)4.21741244
29neuron-neuron synaptic transmission (GO:0007270)4.14277589
30dendritic spine morphogenesis (GO:0060997)4.11451628
31long-term memory (GO:0007616)4.08851228
32gamma-aminobutyric acid transport (GO:0015812)4.05185865
33regulation of synapse structural plasticity (GO:0051823)3.99808921
34positive regulation of membrane potential (GO:0045838)3.98124038
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.95810509
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.83725702
37regulation of postsynaptic membrane potential (GO:0060078)3.80150505
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.74650638
39synaptic vesicle endocytosis (GO:0048488)3.73845494
40sodium ion export (GO:0071436)3.72963674
41presynaptic membrane organization (GO:0097090)3.72080252
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67807191
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.67332789
44neurotransmitter transport (GO:0006836)3.66410802
45proline transport (GO:0015824)3.65578221
46cerebellar granule cell differentiation (GO:0021707)3.65247195
47cerebellar Purkinje cell differentiation (GO:0021702)3.64320296
48regulation of dendritic spine morphogenesis (GO:0061001)3.61382076
49regulation of neurotransmitter secretion (GO:0046928)3.53383559
50* regulation of synaptic plasticity (GO:0048167)3.51961001
51response to pheromone (GO:0019236)3.47954364
52postsynaptic membrane organization (GO:0001941)3.45072941
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.44383506
54positive regulation of neurotransmitter secretion (GO:0001956)3.43696794
55auditory behavior (GO:0031223)3.40677802
56regulation of neurotransmitter levels (GO:0001505)3.39754654
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.37996288
58neuromuscular process controlling balance (GO:0050885)3.36449852
59activation of protein kinase A activity (GO:0034199)3.36345072
60regulation of synapse maturation (GO:0090128)3.33701565
61neuron recognition (GO:0008038)3.32260418
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31463467
63transmission of nerve impulse (GO:0019226)3.31225180
64membrane hyperpolarization (GO:0060081)3.28738850
65dendrite morphogenesis (GO:0048813)3.27848331
66cochlea development (GO:0090102)3.26010026
67positive regulation of neurotransmitter transport (GO:0051590)3.24971744
68regulation of neurotransmitter transport (GO:0051588)3.24347937
69pyrimidine nucleobase catabolic process (GO:0006208)3.22490764
70response to auditory stimulus (GO:0010996)3.22387470
71innervation (GO:0060384)3.19952527
72membrane depolarization (GO:0051899)3.19900429
73positive regulation of dendritic spine development (GO:0060999)3.18627641
74negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18282965
75* long-term synaptic potentiation (GO:0060291)3.17444143
76cell communication by electrical coupling (GO:0010644)3.14570813
77regulation of vesicle fusion (GO:0031338)3.14055341
78axonal fasciculation (GO:0007413)3.13298392
79positive regulation of dendritic spine morphogenesis (GO:0061003)3.12692392
80membrane depolarization during action potential (GO:0086010)3.12232066
81dendritic spine organization (GO:0097061)3.11387237
82neuromuscular process controlling posture (GO:0050884)3.10753849
83regulation of dendritic spine development (GO:0060998)3.08794740
84response to histamine (GO:0034776)3.07489174
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06911616
86behavioral defense response (GO:0002209)3.04749526
87behavioral fear response (GO:0001662)3.04749526
88negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.04522927
89negative regulation of translation, ncRNA-mediated (GO:0040033)3.04522927
90regulation of translation, ncRNA-mediated (GO:0045974)3.04522927
91positive regulation of synaptic transmission, GABAergic (GO:0032230)3.04068801
92glycine transport (GO:0015816)3.02888262
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.02732380
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00612600
95* learning (GO:0007612)2.99806416
96presynaptic membrane assembly (GO:0097105)2.98989469
97prepulse inhibition (GO:0060134)2.98299378
98synaptic transmission (GO:0007268)2.96751862
99* regulation of synaptic transmission (GO:0050804)2.96420830
100behavioral response to cocaine (GO:0048148)2.94660745
101* synapse assembly (GO:0007416)2.93520003
102regulation of voltage-gated calcium channel activity (GO:1901385)2.93439151
103regulation of ARF protein signal transduction (GO:0032012)2.93265201
104fear response (GO:0042596)2.92078865
105* positive regulation of synaptic transmission (GO:0050806)2.91249147
106regulation of posttranscriptional gene silencing (GO:0060147)2.90875575
107regulation of gene silencing by miRNA (GO:0060964)2.90875575
108regulation of gene silencing by RNA (GO:0060966)2.90875575
109chemosensory behavior (GO:0007635)2.89525024
110central nervous system projection neuron axonogenesis (GO:0021952)2.88870226
111limb bud formation (GO:0060174)2.85541599
112cilium movement (GO:0003341)2.78409760
113nucleobase catabolic process (GO:0046113)2.73727022
114regulation of hippo signaling (GO:0035330)2.72691528
115startle response (GO:0001964)2.72079579
116apical protein localization (GO:0045176)2.67653892
117behavioral response to nicotine (GO:0035095)2.66268343
118positive regulation of synapse assembly (GO:0051965)2.63066559
119epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60501333
120negative regulation of sodium ion transport (GO:0010766)2.56757821
121cilium or flagellum-dependent cell motility (GO:0001539)2.56731998
122* synapse organization (GO:0050808)2.52256469
123epithelial cilium movement (GO:0003351)2.51113615
124embryonic retina morphogenesis in camera-type eye (GO:0060059)2.49488329
125positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.48776507
126mechanosensory behavior (GO:0007638)2.48149869
127cell migration in hindbrain (GO:0021535)2.45716149
128neuromuscular synaptic transmission (GO:0007274)2.44100235
129regulation of neuron migration (GO:2001222)2.43065249
130cellular sodium ion homeostasis (GO:0006883)2.42774805
131regulation of synapse assembly (GO:0051963)2.40443469
132axonemal dynein complex assembly (GO:0070286)2.39397168
133central nervous system neuron axonogenesis (GO:0021955)2.37063246
134neurofilament cytoskeleton organization (GO:0060052)2.36296046
135regulation of sodium ion transmembrane transporter activity (GO:2000649)2.32606333
136nephron epithelium morphogenesis (GO:0072088)2.32446141
137nephron tubule morphogenesis (GO:0072078)2.32446141
138neuronal ion channel clustering (GO:0045161)2.32048377
139negative regulation of dendrite development (GO:2000171)2.31951638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.79639487
2GBX2_23144817_ChIP-Seq_PC3_Human3.50093939
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01419370
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00504051
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96881927
6DROSHA_22980978_ChIP-Seq_HELA_Human2.73361777
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69737395
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69737395
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.68127352
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58329708
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51763743
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48487998
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46367393
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45790775
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.43926324
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.38416382
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34103849
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.25531037
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23619302
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.22822257
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.16327665
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.13680184
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05229924
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03157710
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95801258
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92481285
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91966349
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82710253
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82408878
30AR_21572438_ChIP-Seq_LNCaP_Human1.72364360
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70410652
32* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65855264
33VDR_22108803_ChIP-Seq_LS180_Human1.65292695
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.61839315
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.59831840
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.58903072
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54701509
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.52465228
39TAF15_26573619_Chip-Seq_HEK293_Human1.47180674
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44006048
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42692995
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40789480
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.37322581
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.31970775
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30769739
46FUS_26573619_Chip-Seq_HEK293_Human1.30027579
47* ESR2_21235772_ChIP-Seq_MCF-7_Human1.29789126
48* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29665089
49P300_19829295_ChIP-Seq_ESCs_Human1.28244914
50* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28153346
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27470028
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.26305415
53AR_19668381_ChIP-Seq_PC3_Human1.25752275
54ZNF274_21170338_ChIP-Seq_K562_Hela1.23938813
55* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23618035
56* AR_25329375_ChIP-Seq_VCAP_Human1.23424518
57CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23217697
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22952087
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22797486
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22762480
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21589129
62* STAT3_23295773_ChIP-Seq_U87_Human1.20016936
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19673346
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18126181
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17749448
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17576402
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.16776405
68* PIAS1_25552417_ChIP-Seq_VCAP_Human1.15948280
69* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15212573
70* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15017092
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14569881
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.13027866
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11632825
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.10879259
75ER_23166858_ChIP-Seq_MCF-7_Human1.10161017
76* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10002940
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09444845
78* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09127451
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.08682249
80KDM2B_26808549_Chip-Seq_K562_Human1.06917974
81* TCF4_23295773_ChIP-Seq_U87_Human1.06747670
82EWS_26573619_Chip-Seq_HEK293_Human1.04756209
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03959927
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03463372
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02683814
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02345182
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01389265
88AHR_22903824_ChIP-Seq_MCF-7_Human1.01326777
89* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01299537
90TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01041234
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00738319
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00703759
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.00508069
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00358703
95* SMAD4_21741376_ChIP-Seq_HESCs_Human1.00216702
96BCAT_22108803_ChIP-Seq_LS180_Human1.00179899
97ISL1_27105846_Chip-Seq_CPCs_Mouse0.99793237
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98539787
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98467122
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98152294
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98028613
102CBP_20019798_ChIP-Seq_JUKART_Human0.98028613
103RNF2_27304074_Chip-Seq_NSC_Mouse0.96502823
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96071002
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96071002
106* TCF4_22108803_ChIP-Seq_LS180_Human0.96038927
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95335825
108RUNX2_22187159_ChIP-Seq_PCA_Human0.94021184
109TP53_16413492_ChIP-PET_HCT116_Human0.93316953
110* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91067291
111ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90685901
112* SMAD3_21741376_ChIP-Seq_ESCs_Human0.90081762
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89964880
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89475573
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86777412
116* PRDM14_20953172_ChIP-Seq_ESCs_Human0.85852198
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84248157
118IGF1R_20145208_ChIP-Seq_DFB_Human0.83921281
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83543820
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83329734
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82905474
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82777704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.83507789
2MP0003880_abnormal_central_pattern4.56369658
3MP0003635_abnormal_synaptic_transmissio4.26307807
4MP0004270_analgesia3.65560908
5MP0009745_abnormal_behavioral_response3.47052566
6MP0002063_abnormal_learning/memory/cond3.39403175
7MP0009046_muscle_twitch3.33653632
8MP0002064_seizures3.18310025
9MP0001968_abnormal_touch/_nociception2.94548286
10MP0005423_abnormal_somatic_nervous2.88077022
11MP0002572_abnormal_emotion/affect_behav2.85973021
12MP0001486_abnormal_startle_reflex2.68415429
13MP0002734_abnormal_mechanical_nocicepti2.62375191
14MP0002822_catalepsy2.62016458
15MP0002272_abnormal_nervous_system2.59940774
16MP0000566_synostosis2.37791308
17MP0001501_abnormal_sleep_pattern2.36775926
18MP0002736_abnormal_nociception_after2.22056903
19MP0001440_abnormal_grooming_behavior2.19913912
20MP0002735_abnormal_chemical_nociception2.11121051
21MP0003879_abnormal_hair_cell2.08097295
22MP0008569_lethality_at_weaning2.04685940
23MP0009780_abnormal_chondrocyte_physiolo2.03656569
24MP0002067_abnormal_sensory_capabilities2.02923687
25MP0002184_abnormal_innervation1.89207920
26MP0002557_abnormal_social/conspecific_i1.84446977
27MP0001984_abnormal_olfaction1.83884492
28MP0002733_abnormal_thermal_nociception1.83332933
29MP0001970_abnormal_pain_threshold1.80155810
30MP0003329_amyloid_beta_deposits1.74975982
31MP0000778_abnormal_nervous_system1.73523133
32MP0004811_abnormal_neuron_physiology1.71528467
33MP0005386_behavior/neurological_phenoty1.71387263
34MP0004924_abnormal_behavior1.71387263
35MP0002909_abnormal_adrenal_gland1.65895261
36MP0004858_abnormal_nervous_system1.65265345
37MP0004133_heterotaxia1.65195866
38MP0004885_abnormal_endolymph1.64952911
39MP0005646_abnormal_pituitary_gland1.63514031
40MP0000955_abnormal_spinal_cord1.45671736
41MP0006276_abnormal_autonomic_nervous1.45086776
42MP0001502_abnormal_circadian_rhythm1.42317723
43MP0002066_abnormal_motor_capabilities/c1.40820566
44MP0003890_abnormal_embryonic-extraembry1.40313970
45MP0002882_abnormal_neuron_morphology1.39749515
46MP0003123_paternal_imprinting1.35831010
47MP0005645_abnormal_hypothalamus_physiol1.34780652
48MP0003633_abnormal_nervous_system1.34175782
49MP0008875_abnormal_xenobiotic_pharmacok1.32365821
50MP0005551_abnormal_eye_electrophysiolog1.25080533
51MP0003121_genomic_imprinting1.22516411
52MP0008877_abnormal_DNA_methylation1.22423399
53MP0003787_abnormal_imprinting1.21589318
54MP0004142_abnormal_muscle_tone1.19403044
55MP0000579_abnormal_nail_morphology1.14345684
56MP0003631_nervous_system_phenotype1.13605400
57MP0000569_abnormal_digit_pigmentation1.13049824
58MP0008872_abnormal_physiological_respon1.12465975
59MP0002152_abnormal_brain_morphology1.10822793
60MP0002653_abnormal_ependyma_morphology1.09133006
61MP0004742_abnormal_vestibular_system1.07628838
62MP0003941_abnormal_skin_development1.07625791
63MP0001346_abnormal_lacrimal_gland1.05803042
64MP0003938_abnormal_ear_development1.02486233
65MP0003195_calcinosis1.01378817
66MP0002069_abnormal_eating/drinking_beha1.00865583
67MP0004145_abnormal_muscle_electrophysio1.00779514
68MP0010386_abnormal_urinary_bladder1.00707596
69MP0003119_abnormal_digestive_system1.00081242
70MP0001529_abnormal_vocalization0.98823745
71MP0001188_hyperpigmentation0.98628806
72MP0001177_atelectasis0.98302927
73MP0002229_neurodegeneration0.98255628
74MP0001905_abnormal_dopamine_level0.95606068
75MP0008874_decreased_physiological_sensi0.95130914
76MP0002102_abnormal_ear_morphology0.94351495
77MP0001299_abnormal_eye_distance/0.92942440
78MP0002249_abnormal_larynx_morphology0.92017167
79MP0003937_abnormal_limbs/digits/tail_de0.91283991
80MP0002751_abnormal_autonomic_nervous0.89735081
81MP0001963_abnormal_hearing_physiology0.87103976
82MP0000383_abnormal_hair_follicle0.86726700
83MP0008961_abnormal_basal_metabolism0.85786489
84MP0002090_abnormal_vision0.85277978
85MP0003632_abnormal_nervous_system0.85024126
86MP0003690_abnormal_glial_cell0.84955647
87MP0002938_white_spotting0.84290682
88MP0005535_abnormal_body_temperature0.84096070
89MP0003075_altered_response_to0.83896341
90MP0006292_abnormal_olfactory_placode0.83596262
91MP0001485_abnormal_pinna_reflex0.83414212
92MP0009703_decreased_birth_body0.83337498
93MP0004085_abnormal_heartbeat0.81569043
94MP0002089_abnormal_postnatal_growth/wei0.81491878
95MP0000534_abnormal_ureter_morphology0.80742078
96MP0003122_maternal_imprinting0.79728633
97MP0003942_abnormal_urinary_system0.78671172
98MP0002233_abnormal_nose_morphology0.76639851
99MP0000751_myopathy0.76372149
100MP0000604_amyloidosis0.76245050
101MP0004043_abnormal_pH_regulation0.75717310
102MP0002752_abnormal_somatic_nervous0.75673435
103MP0009672_abnormal_birth_weight0.75593538
104MP0000631_abnormal_neuroendocrine_gland0.74022784
105MP0005499_abnormal_olfactory_system0.73950334
106MP0005394_taste/olfaction_phenotype0.73950334
107MP0004233_abnormal_muscle_weight0.72315724
108MP0003634_abnormal_glial_cell0.71919199
109MP0001666_abnormal_nutrient_absorption0.71239078
110MP0003755_abnormal_palate_morphology0.70772522
111MP0003283_abnormal_digestive_organ0.70183186
112MP0001664_abnormal_digestion0.67886298
113MP0002234_abnormal_pharynx_morphology0.66027001
114MP0005377_hearing/vestibular/ear_phenot0.65478081
115MP0003137_abnormal_impulse_conducting0.62372548
116MP0002638_abnormal_pupillary_reflex0.62330153
117MP0002876_abnormal_thyroid_physiology0.61165261
118MP0005187_abnormal_penis_morphology0.61127381
119MP0000920_abnormal_myelination0.59762368
120MP0000013_abnormal_adipose_tissue0.59046897
121MP0004215_abnormal_myocardial_fiber0.58903464
122MP0004484_altered_response_of0.57825709
123MP0005167_abnormal_blood-brain_barrier0.56634914
124MP0010769_abnormal_survival0.54897672
125MP0003861_abnormal_nervous_system0.54126686
126MP0002082_postnatal_lethality0.53401804
127MP0010770_preweaning_lethality0.53401804
128MP0003045_fibrosis0.52879096
129MP0000026_abnormal_inner_ear0.52052481
130MP0010768_mortality/aging0.51423091
131MP0010234_abnormal_vibrissa_follicle0.49285575
132MP0001943_abnormal_respiration0.49255120

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.62103972
2Myokymia (HP:0002411)6.77066052
3Focal seizures (HP:0007359)5.83053485
4Visual hallucinations (HP:0002367)5.36885284
5Epileptic encephalopathy (HP:0200134)5.17533984
6Progressive cerebellar ataxia (HP:0002073)4.99493664
7Febrile seizures (HP:0002373)4.69693370
8Atonic seizures (HP:0010819)4.45503432
9Action tremor (HP:0002345)4.42994023
10Absence seizures (HP:0002121)4.37568569
11Generalized tonic-clonic seizures (HP:0002069)3.93598536
12Dialeptic seizures (HP:0011146)3.92381755
13Gaze-evoked nystagmus (HP:0000640)3.92033706
14Broad-based gait (HP:0002136)3.86432163
15Hyperventilation (HP:0002883)3.64924120
16Poor eye contact (HP:0000817)3.61454049
17Dysdiadochokinesis (HP:0002075)3.54863786
18Genetic anticipation (HP:0003743)3.35641301
19Impaired social interactions (HP:0000735)3.31758152
20Abnormal social behavior (HP:0012433)3.31758152
21Impaired vibration sensation in the lower limbs (HP:0002166)3.23565948
22Dysmetria (HP:0001310)3.23120525
23Depression (HP:0000716)3.21702812
24Supranuclear gaze palsy (HP:0000605)3.20562990
25Impaired smooth pursuit (HP:0007772)3.13017851
26Abnormality of the lower motor neuron (HP:0002366)3.11319223
27Ankle clonus (HP:0011448)3.10434690
28Truncal ataxia (HP:0002078)3.03965152
29Anxiety (HP:0000739)3.03853311
30Urinary bladder sphincter dysfunction (HP:0002839)3.01760303
31Postural instability (HP:0002172)3.01605066
32Bronchomalacia (HP:0002780)2.98446112
33Dysmetric saccades (HP:0000641)2.93574774
34Scanning speech (HP:0002168)2.91587635
35Abnormal eating behavior (HP:0100738)2.91413146
36Mutism (HP:0002300)2.87982444
37Amblyopia (HP:0000646)2.87465351
38Abnormality of the labia minora (HP:0012880)2.84358602
39Hemiplegia (HP:0002301)2.82165148
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.80340967
41Excessive salivation (HP:0003781)2.80007113
42Drooling (HP:0002307)2.80007113
43Hemiparesis (HP:0001269)2.79222341
44Abnormality of ocular smooth pursuit (HP:0000617)2.78237833
45Sleep apnea (HP:0010535)2.76485678
46Torticollis (HP:0000473)2.74868292
47Intention tremor (HP:0002080)2.73662446
48Status epilepticus (HP:0002133)2.73172428
49Epileptiform EEG discharges (HP:0011182)2.65649620
50Focal dystonia (HP:0004373)2.59350575
51Stereotypic behavior (HP:0000733)2.56162420
52Papilledema (HP:0001085)2.56154827
53Abnormality of binocular vision (HP:0011514)2.55197819
54Diplopia (HP:0000651)2.55197819
55EEG with generalized epileptiform discharges (HP:0011198)2.53122428
56Hepatoblastoma (HP:0002884)2.52667868
57Abnormal ciliary motility (HP:0012262)2.51797755
58Abnormal respiratory motile cilium physiology (HP:0012261)2.47909228
59Ventricular fibrillation (HP:0001663)2.45140907
60Abnormal respiratory motile cilium morphology (HP:0005938)2.43935614
61Abnormal respiratory epithelium morphology (HP:0012253)2.43935614
62Urinary urgency (HP:0000012)2.43146399
63Spastic gait (HP:0002064)2.42982365
64True hermaphroditism (HP:0010459)2.40787582
65Nephronophthisis (HP:0000090)2.36183900
66Bradykinesia (HP:0002067)2.35875148
67Cerebral inclusion bodies (HP:0100314)2.35003145
68Impaired vibratory sensation (HP:0002495)2.34460501
69Absent speech (HP:0001344)2.34409981
70Agitation (HP:0000713)2.32986843
71Hypsarrhythmia (HP:0002521)2.32589073
72Neurofibrillary tangles (HP:0002185)2.32183135
73Molar tooth sign on MRI (HP:0002419)2.27241538
74Abnormality of midbrain morphology (HP:0002418)2.27241538
75Craniofacial dystonia (HP:0012179)2.26017835
76Fetal akinesia sequence (HP:0001989)2.25756351
77Rhinitis (HP:0012384)2.21263169
78Chronic bronchitis (HP:0004469)2.20485181
79Gait imbalance (HP:0002141)2.18457054
80Megalencephaly (HP:0001355)2.17756324
81Progressive inability to walk (HP:0002505)2.15925299
82Pancreatic cysts (HP:0001737)2.14297721
83Labial hypoplasia (HP:0000066)2.13215375
84Obstructive sleep apnea (HP:0002870)2.12676543
85Generalized myoclonic seizures (HP:0002123)2.11153831
86Abnormality of the corticospinal tract (HP:0002492)2.10723296
87Abnormality of the renal medulla (HP:0100957)2.10657609
88Cystic liver disease (HP:0006706)2.10199480
89Pancreatic fibrosis (HP:0100732)2.09059135
90Aplasia/Hypoplasia of the sternum (HP:0006714)2.06921491
91Annular pancreas (HP:0001734)2.06829848
92Vaginal atresia (HP:0000148)2.06788866
93Genital tract atresia (HP:0001827)2.05070425
94Gait ataxia (HP:0002066)2.03807290
95Incomplete penetrance (HP:0003829)2.02318151
96Alacrima (HP:0000522)2.02171214
97Lissencephaly (HP:0001339)1.99904517
98Inability to walk (HP:0002540)1.99035829
99Polyphagia (HP:0002591)1.97561227
100Abnormality of saccadic eye movements (HP:0000570)1.97482978
101Blue irides (HP:0000635)1.97192821
102Insidious onset (HP:0003587)1.96961001
103Termporal pattern (HP:0011008)1.96961001
104Lower limb muscle weakness (HP:0007340)1.96073609
105Scrotal hypoplasia (HP:0000046)1.95613630
106Pointed chin (HP:0000307)1.94891333
107Hypoplastic female external genitalia (HP:0012815)1.89822724
108Hypoplastic labia majora (HP:0000059)1.88970604
109Amyotrophic lateral sclerosis (HP:0007354)1.88116265
110Limb dystonia (HP:0002451)1.87428042
111Abnormality of salivation (HP:0100755)1.85144196
112Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84403972
113Type II lissencephaly (HP:0007260)1.82714578
114Lower limb asymmetry (HP:0100559)1.80553576
115Clonus (HP:0002169)1.80541989
116Insomnia (HP:0100785)1.79908875
117Chronic hepatic failure (HP:0100626)1.79416644
118Medial flaring of the eyebrow (HP:0010747)1.79165919
119Psychosis (HP:0000709)1.77633068
120Morphological abnormality of the middle ear (HP:0008609)1.76539544
121Inappropriate behavior (HP:0000719)1.75087246
122Gastroesophageal reflux (HP:0002020)1.74722170
123Tetraplegia (HP:0002445)1.74660635
124Abnormal EKG (HP:0003115)1.74638996
125Congenital primary aphakia (HP:0007707)1.74135882
126Protruding tongue (HP:0010808)1.73934769
127Limb ataxia (HP:0002070)1.73821307
128Tubular atrophy (HP:0000092)1.72766605
129Cutaneous finger syndactyly (HP:0010554)1.71832446
130Bundle branch block (HP:0011710)1.71724009
131Neuronal loss in central nervous system (HP:0002529)1.70824027
132Clumsiness (HP:0002312)1.69786137
133Rigidity (HP:0002063)1.68953618
134Abnormality of macular pigmentation (HP:0008002)1.67491187
135Abnormality of the pubic bones (HP:0003172)1.67401365
136Central scotoma (HP:0000603)1.67104152
137Poor coordination (HP:0002370)1.66920603
138Absent/shortened dynein arms (HP:0200106)1.66471532
139Dynein arm defect of respiratory motile cilia (HP:0012255)1.66471532
140Hyperglycinuria (HP:0003108)1.65820711
141Abnormality of the labia majora (HP:0012881)1.64129165
142Postural tremor (HP:0002174)1.63634222
143Increased circulating renin level (HP:0000848)1.63566909
144Choanal stenosis (HP:0000452)1.59491696
145Morphological abnormality of the pyramidal tract (HP:0002062)1.58908012
146Nephrogenic diabetes insipidus (HP:0009806)1.58758816
147Decreased lacrimation (HP:0000633)1.56968762
148Cerebellar dysplasia (HP:0007033)1.56755680
149Bifid scrotum (HP:0000048)1.55160094
150Specific learning disability (HP:0001328)1.53247148
151Optic nerve hypoplasia (HP:0000609)1.51730619
152Aqueductal stenosis (HP:0002410)1.51549373
153Tented upper lip vermilion (HP:0010804)1.51214304
154Cupped ear (HP:0000378)1.49686893
155Tracheomalacia (HP:0002779)1.49342596
156Concave nail (HP:0001598)1.49088610
157Midline defect of the nose (HP:0004122)1.48800958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.31078586
2EPHA44.24335333
3MAP3K93.64088438
4MARK13.16628255
5DAPK23.02950344
6MAP3K43.02383749
7MINK12.67021659
8MAP2K72.53012992
9PAK62.41939805
10FRK2.24271723
11MAPK152.21744513
12NTRK22.20817086
13MAP2K42.02023849
14CAMKK11.98706585
15PRKD31.98299200
16CASK1.96637416
17CAMK1D1.82084498
18SIK21.79614830
19DAPK11.72831470
20KSR21.72366596
21MAP3K121.71828310
22STK381.67394102
23RIPK41.59013656
24BCR1.56505148
25PRPF4B1.54503097
26CDK51.53239665
27NTRK11.51830738
28KSR11.50900494
29TNIK1.48098777
30PLK21.35927341
31EPHA21.32392217
32CAMKK21.30611607
33PRKCG1.29829327
34CDK191.29148169
35STK391.29109720
36DYRK21.28819859
37MAPK131.27203184
38LATS11.26683105
39GRK51.26272717
40PKN21.22114806
41WNK41.21648280
42PNCK1.21530275
43TYRO31.16074482
44CAMK11.13991113
45MAP4K21.09359792
46RIPK11.06165637
47SGK2231.04252062
48SGK4941.04252062
49MKNK21.01668353
50SIK30.99125508
51TAOK10.98498284
52STK110.98462208
53FES0.97179660
54CAMK2A0.96653367
55SGK20.95373248
56MAP3K130.95125767
57PIK3CA0.94461230
58MAP3K20.94090682
59GRK10.92871222
60TRIM280.92383298
61OXSR10.91136516
62MARK20.90370557
63PHKG20.89841329
64PHKG10.89841329
65TRIB30.86910360
66UHMK10.86512009
67CDK180.86444202
68LATS20.86347989
69CDK150.84611146
70DYRK1A0.82630514
71SGK30.81470226
72PRKCH0.80567353
73STK38L0.80272378
74CAMK1G0.79856480
75PAK30.78118523
76BMPR1B0.78041493
77ARAF0.77556949
78CAMK2B0.77441371
79PINK10.77288536
80CDK140.76336551
81NUAK10.74814325
82PTK2B0.74810427
83SGK10.74250902
84CDK120.74219742
85INSRR0.73602190
86TSSK60.72903020
87RET0.72531861
88CDK11A0.72478934
89CDK30.70885418
90ERBB20.70650630
91ADRBK20.65997714
92CAMK40.65180059
93CSNK1G20.63513504
94MAP3K70.63410415
95PRKCZ0.61975575
96WNK30.61330856
97PDK10.61317696
98BMPR20.60572537
99CSNK1A1L0.60540346
100ALK0.59706007
101LMTK20.57450480
102* CSNK1E0.56936364
103RAF10.56067618
104TNK20.55507173
105PDPK10.52599803
106CDC42BPA0.52593785
107WNK10.50809423
108* RPS6KA30.50796626
109FGFR10.50404936
110PRKAA10.50261290
111FGFR20.49158249
112FER0.48533812
113ICK0.47938662
114ZAK0.47380114
115PRKCI0.46823693
116MAPK80.46713946
117FYN0.46660427
118CSNK1G10.45678899
119PRKCE0.45672690
120CSNK1A10.45356510
121CAMK2G0.44955603
122GSK3B0.44925548
123MAP3K60.44858240
124CCNB10.44114866
125CSNK1D0.43373584
126NEK60.43029095
127CAMK2D0.42599691
128MAPK100.41559890
129MAP3K10.39684860
130NEK10.38536537
131NME10.37497118
132AKT30.36793736
133DAPK30.36210732
134MAPK120.34758234
135BRSK10.32671681
136PRKCB0.32022132
137FGR0.31756305

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.96774798
2Synaptic vesicle cycle_Homo sapiens_hsa047213.27932192
3GABAergic synapse_Homo sapiens_hsa047272.76332176
4Circadian entrainment_Homo sapiens_hsa047132.75791445
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75447421
6Olfactory transduction_Homo sapiens_hsa047402.67985421
7* Glutamatergic synapse_Homo sapiens_hsa047242.62579336
8Long-term potentiation_Homo sapiens_hsa047202.59175088
9Morphine addiction_Homo sapiens_hsa050322.51977376
10Amphetamine addiction_Homo sapiens_hsa050312.36440140
11Salivary secretion_Homo sapiens_hsa049702.23621423
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15665889
13Dopaminergic synapse_Homo sapiens_hsa047282.04885166
14Insulin secretion_Homo sapiens_hsa049112.03610340
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92372588
16Gastric acid secretion_Homo sapiens_hsa049711.90241103
17Cholinergic synapse_Homo sapiens_hsa047251.84808291
18Taste transduction_Homo sapiens_hsa047421.80917918
19Long-term depression_Homo sapiens_hsa047301.67463983
20Vitamin B6 metabolism_Homo sapiens_hsa007501.64408307
21Oxytocin signaling pathway_Homo sapiens_hsa049211.61105449
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58830608
23Renin secretion_Homo sapiens_hsa049241.58335163
24Calcium signaling pathway_Homo sapiens_hsa040201.58319043
25Nitrogen metabolism_Homo sapiens_hsa009101.57744712
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50971244
27Serotonergic synapse_Homo sapiens_hsa047261.50137746
28Cocaine addiction_Homo sapiens_hsa050301.48757403
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46647556
30GnRH signaling pathway_Homo sapiens_hsa049121.38070105
31Histidine metabolism_Homo sapiens_hsa003401.34909563
32Type II diabetes mellitus_Homo sapiens_hsa049301.27138960
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26119691
34cAMP signaling pathway_Homo sapiens_hsa040241.26061515
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25046001
36Gap junction_Homo sapiens_hsa045401.24727944
37Collecting duct acid secretion_Homo sapiens_hsa049661.24551992
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21341570
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17744920
40Steroid biosynthesis_Homo sapiens_hsa001001.14612811
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14332899
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14175563
43Tight junction_Homo sapiens_hsa045301.12457071
44Linoleic acid metabolism_Homo sapiens_hsa005911.08274477
45Estrogen signaling pathway_Homo sapiens_hsa049151.07969394
46Lysine degradation_Homo sapiens_hsa003101.07030307
47Pancreatic secretion_Homo sapiens_hsa049721.03922842
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03202827
49Axon guidance_Homo sapiens_hsa043601.03114823
50Glioma_Homo sapiens_hsa052141.01509744
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99506170
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98075241
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.96981465
54ErbB signaling pathway_Homo sapiens_hsa040120.96426813
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96128008
56Caffeine metabolism_Homo sapiens_hsa002320.95766073
57Melanogenesis_Homo sapiens_hsa049160.94958505
58Chemical carcinogenesis_Homo sapiens_hsa052040.94397048
59Hippo signaling pathway_Homo sapiens_hsa043900.93570335
60ABC transporters_Homo sapiens_hsa020100.93389749
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92469641
62beta-Alanine metabolism_Homo sapiens_hsa004100.89886164
63Phototransduction_Homo sapiens_hsa047440.88854977
64Retinol metabolism_Homo sapiens_hsa008300.87186484
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86825733
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.86366431
67Bile secretion_Homo sapiens_hsa049760.86126248
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.84998343
69Thyroid hormone synthesis_Homo sapiens_hsa049180.83560589
70Propanoate metabolism_Homo sapiens_hsa006400.82826275
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82232391
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.78055863
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77489599
74Cardiac muscle contraction_Homo sapiens_hsa042600.75985098
75Phenylalanine metabolism_Homo sapiens_hsa003600.75115634
76Vitamin digestion and absorption_Homo sapiens_hsa049770.73371777
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72597471
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72539181
79Ether lipid metabolism_Homo sapiens_hsa005650.72256997
80Circadian rhythm_Homo sapiens_hsa047100.72112652
81Choline metabolism in cancer_Homo sapiens_hsa052310.71149424
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.70563722
83Dorso-ventral axis formation_Homo sapiens_hsa043200.69611695
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69422848
85Vibrio cholerae infection_Homo sapiens_hsa051100.67844675
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67279865
87Oocyte meiosis_Homo sapiens_hsa041140.66066229
88Dilated cardiomyopathy_Homo sapiens_hsa054140.66063315
89Tryptophan metabolism_Homo sapiens_hsa003800.64553183
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64391219
91Arginine biosynthesis_Homo sapiens_hsa002200.63786355
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62220039
93MAPK signaling pathway_Homo sapiens_hsa040100.61582293
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61039191
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60291785
96Glucagon signaling pathway_Homo sapiens_hsa049220.58560153
97Basal cell carcinoma_Homo sapiens_hsa052170.57915915
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57735485
99Adherens junction_Homo sapiens_hsa045200.56432733
100Selenocompound metabolism_Homo sapiens_hsa004500.55995456
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55704360
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54121023
103Inositol phosphate metabolism_Homo sapiens_hsa005620.53281138
104Arginine and proline metabolism_Homo sapiens_hsa003300.53151278
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52567274
106Fat digestion and absorption_Homo sapiens_hsa049750.52369933
107Hedgehog signaling pathway_Homo sapiens_hsa043400.51748345
108Rap1 signaling pathway_Homo sapiens_hsa040150.50064638
109Tyrosine metabolism_Homo sapiens_hsa003500.49108321
110Ras signaling pathway_Homo sapiens_hsa040140.48789141
111VEGF signaling pathway_Homo sapiens_hsa043700.48553275
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48377922
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.47071815
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46552612
115mTOR signaling pathway_Homo sapiens_hsa041500.46210987
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44247253
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44120188
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44097891
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43929908
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42893358
121Ovarian steroidogenesis_Homo sapiens_hsa049130.41100141
122Butanoate metabolism_Homo sapiens_hsa006500.39595062
123Endocytosis_Homo sapiens_hsa041440.37912437
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37871599
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.36496762
126Endometrial cancer_Homo sapiens_hsa052130.35849579
127Wnt signaling pathway_Homo sapiens_hsa043100.34881479
128African trypanosomiasis_Homo sapiens_hsa051430.33785734
129Alcoholism_Homo sapiens_hsa050340.32893615
130Insulin signaling pathway_Homo sapiens_hsa049100.31918635
131Mineral absorption_Homo sapiens_hsa049780.30783391
132Non-small cell lung cancer_Homo sapiens_hsa052230.30516491
133Renal cell carcinoma_Homo sapiens_hsa052110.30320631
134Prion diseases_Homo sapiens_hsa050200.28751299
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24887683
136Fatty acid biosynthesis_Homo sapiens_hsa000610.24324874
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24265094
138Type I diabetes mellitus_Homo sapiens_hsa049400.23429072
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23151842
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.23067200

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