SHARPIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.21465772
2DNA deamination (GO:0045006)6.09295979
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.95432427
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.95432427
5positive regulation of gamma-delta T cell activation (GO:0046645)4.89532280
6proline metabolic process (GO:0006560)4.85301242
7cellular response to zinc ion (GO:0071294)4.62473655
8antigen processing and presentation of endogenous antigen (GO:0019883)4.60412021
9positive regulation of protein homooligomerization (GO:0032464)4.53899787
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.48819968
11replication fork processing (GO:0031297)4.29482007
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.19981336
13transcription from mitochondrial promoter (GO:0006390)4.17152250
14regulation of B cell receptor signaling pathway (GO:0050855)4.05488678
15embryonic process involved in female pregnancy (GO:0060136)4.01951788
16maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.01012558
17regulation of gamma-delta T cell differentiation (GO:0045586)3.98388158
18regulation of gamma-delta T cell activation (GO:0046643)3.72709570
19telomere maintenance via semi-conservative replication (GO:0032201)3.56229600
20antigen processing and presentation via MHC class Ib (GO:0002475)3.55313207
21UV protection (GO:0009650)3.54344399
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50555407
23regulation of B cell differentiation (GO:0045577)3.49112152
24positive regulation of B cell differentiation (GO:0045579)3.46454290
25negative regulation of cell size (GO:0045792)3.46369906
26regulation of protein homooligomerization (GO:0032462)3.44236332
27modulation by virus of host process (GO:0019054)3.42578833
28mannose metabolic process (GO:0006013)3.41877203
29protein maturation by protein folding (GO:0022417)3.40120430
30mitochondrial DNA metabolic process (GO:0032042)3.36294096
31B cell receptor signaling pathway (GO:0050853)3.35488417
32negative regulation of erythrocyte differentiation (GO:0045647)3.32556966
33response to peptidoglycan (GO:0032494)3.23848465
34positive regulation of lamellipodium assembly (GO:0010592)3.23436918
35Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21243015
36barbed-end actin filament capping (GO:0051016)3.18666881
37DNA strand renaturation (GO:0000733)3.18397939
38leukocyte aggregation (GO:0070486)3.15304424
39neutrophil activation involved in immune response (GO:0002283)3.13490807
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.12914094
41modulation by symbiont of host cellular process (GO:0044068)3.12199992
42oxidative demethylation (GO:0070989)3.11933635
43positive regulation of Cdc42 GTPase activity (GO:0043089)3.11611575
44heme biosynthetic process (GO:0006783)3.10940675
45positive regulation of protein oligomerization (GO:0032461)3.10543060
46ribosomal small subunit assembly (GO:0000028)3.09346040
47immunoglobulin mediated immune response (GO:0016064)3.08316841
48viral mRNA export from host cell nucleus (GO:0046784)3.06359051
49protein retention in ER lumen (GO:0006621)3.04541570
50somatic hypermutation of immunoglobulin genes (GO:0016446)3.04262222
51somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04262222
52adenosine receptor signaling pathway (GO:0001973)3.03695892
53protoporphyrinogen IX metabolic process (GO:0046501)3.03565123
54negative regulation of cell killing (GO:0031342)3.01602682
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.01602682
56regulation of mast cell degranulation (GO:0043304)3.00946620
57positive thymic T cell selection (GO:0045059)2.99976169
58viral protein processing (GO:0019082)2.99859832
59negative regulation of stress fiber assembly (GO:0051497)2.98421741
60cellular response to virus (GO:0098586)2.98274310
61pinocytosis (GO:0006907)2.93402709
62negative thymic T cell selection (GO:0045060)2.93346862
63pentose-phosphate shunt (GO:0006098)2.91005453
64T cell migration (GO:0072678)2.90778904
65positive regulation of lamellipodium organization (GO:1902745)2.90218273
66regulation of integrin activation (GO:0033623)2.89939537
67pentose metabolic process (GO:0019321)2.89691724
68dosage compensation (GO:0007549)2.89245457
69protoporphyrinogen IX biosynthetic process (GO:0006782)2.88916381
70telomere maintenance via recombination (GO:0000722)2.88311686
71negative T cell selection (GO:0043383)2.87393124
72negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.86920043
73negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.85337557
74regulation of necrotic cell death (GO:0010939)2.80035957
75mitotic G1 DNA damage checkpoint (GO:0031571)2.78138578
76positive regulation by symbiont of host defense response (GO:0052509)2.77216180
77modulation by symbiont of host defense response (GO:0052031)2.77216180
78modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.77216180
79modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.77216180
80positive regulation by organism of defense response of other organism involved in symbiotic interact2.77216180
81modulation by symbiont of host immune response (GO:0052553)2.77216180
82regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75971187
83regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.75074913
84virion assembly (GO:0019068)2.74590268
85apoptotic process involved in morphogenesis (GO:0060561)2.73105809
86nucleotide-excision repair, DNA gap filling (GO:0006297)2.71906156
87glucose catabolic process (GO:0006007)2.71147707
88negative regulation of interleukin-12 production (GO:0032695)2.70678622
89glutamine family amino acid biosynthetic process (GO:0009084)2.70517328
90heme metabolic process (GO:0042168)2.70298470
91amyloid precursor protein catabolic process (GO:0042987)2.70250390
92regulation of alpha-beta T cell proliferation (GO:0046640)2.70196424
93lipoxygenase pathway (GO:0019372)2.69744369
94defense response to protozoan (GO:0042832)2.67491888
95regulation of leukocyte degranulation (GO:0043300)2.67179447
96positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.67133349
97response to type I interferon (GO:0034340)2.66131821
98DNA strand elongation involved in DNA replication (GO:0006271)2.65736995
99type I interferon signaling pathway (GO:0060337)2.64770994
100cellular response to type I interferon (GO:0071357)2.64770994
101base-excision repair (GO:0006284)2.64326108
102regulation of protein oligomerization (GO:0032459)2.64286461
103maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.62471990
104detection of bacterium (GO:0016045)2.61956447
105regulation of mast cell activation involved in immune response (GO:0033006)2.61777355
106negative regulation of cell cycle arrest (GO:0071157)2.60662720
107regulation of type I interferon-mediated signaling pathway (GO:0060338)2.60042452
108regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.58934049
109pyrimidine nucleoside salvage (GO:0043097)2.58920213
110pyrimidine-containing compound salvage (GO:0008655)2.58920213
111mature B cell differentiation involved in immune response (GO:0002313)2.58349203
112positive regulation of histone deacetylation (GO:0031065)2.58267700
113mRNA cleavage (GO:0006379)2.57970985
114mitochondrial DNA replication (GO:0006264)2.56352211
115NIK/NF-kappaB signaling (GO:0038061)2.56323186
116negative regulation of protein oligomerization (GO:0032460)2.56182183
117pyrimidine nucleotide catabolic process (GO:0006244)2.56070083
118response to protozoan (GO:0001562)2.56046244
119leukocyte cell-cell adhesion (GO:0007159)2.54515165
120negative regulation of tumor necrosis factor production (GO:0032720)2.54075980
121positive regulation of alpha-beta T cell proliferation (GO:0046641)2.53928859
122negative regulation of RNA splicing (GO:0033119)2.52422895
123DNA strand elongation (GO:0022616)2.52415357
124B cell mediated immunity (GO:0019724)2.50281478
125nucleotide salvage (GO:0043173)2.49960406
126regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.48664345
127negative regulation of phagocytosis (GO:0050765)2.48060353
128positive regulation of odontogenesis (GO:0042482)2.47723993
129cellular response to interferon-beta (GO:0035458)2.47122549
130negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.46943903
131negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.46663647
132thymic T cell selection (GO:0045061)2.45535197
133retinoic acid receptor signaling pathway (GO:0048384)2.45411319
134GDP-mannose metabolic process (GO:0019673)2.45319332
135regulation of T-helper 2 cell differentiation (GO:0045628)2.45209963
136response to interleukin-15 (GO:0070672)2.44755062
137poly(A)+ mRNA export from nucleus (GO:0016973)2.44487089
138detection of other organism (GO:0098543)2.44306346
139stress fiber assembly (GO:0043149)2.44204842
140formation of translation preinitiation complex (GO:0001731)2.43232786
141deoxyribonucleotide catabolic process (GO:0009264)2.42167734
142sequestering of actin monomers (GO:0042989)2.41820706
143negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.41341053
144positive regulation of lipoprotein lipase activity (GO:0051006)2.40296671
145positive regulation of triglyceride lipase activity (GO:0061365)2.40296671
146telomere maintenance via telomere lengthening (GO:0010833)2.39819625
147mature B cell differentiation (GO:0002335)2.39716789
148viral transcription (GO:0019083)2.39533528
149porphyrin-containing compound biosynthetic process (GO:0006779)2.39505813
150mitotic recombination (GO:0006312)2.39114482
151regulation of lamellipodium assembly (GO:0010591)2.38910617
152regulation of defense response to virus by virus (GO:0050690)2.38299942
153response to interferon-beta (GO:0035456)2.37198371
154G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.37107362
155amino sugar catabolic process (GO:0046348)2.36736072
156regulation of response to interferon-gamma (GO:0060330)2.36268290
157embryonic placenta development (GO:0001892)2.35570597
158mitotic G1/S transition checkpoint (GO:0044819)2.34555548
159regulation of superoxide anion generation (GO:0032928)2.34284105
160regulation of interleukin-12 biosynthetic process (GO:0045075)2.33506904
161positive regulation of protein deacetylation (GO:0090312)2.33291588
162regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.33060962
163regulation of hydrogen peroxide metabolic process (GO:0010310)2.32840371
164NADPH regeneration (GO:0006740)2.32166744
165protein localization to endosome (GO:0036010)2.31942185
166pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.31426797
167regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.31001391
168COPI coating of Golgi vesicle (GO:0048205)2.29224937
169Golgi transport vesicle coating (GO:0048200)2.29224937
170modulation by virus of host morphology or physiology (GO:0019048)2.28529034
171amyloid precursor protein metabolic process (GO:0042982)2.28426757
172oxygen transport (GO:0015671)2.28312765
173negative regulation of viral release from host cell (GO:1902187)2.28210944
174regulation of tumor necrosis factor production (GO:0032680)2.27346132
175activation of MAPKKK activity (GO:0000185)2.26711351
176negative regulation of necroptotic process (GO:0060546)2.26423626
177hyaluronan catabolic process (GO:0030214)2.23887597
178deoxyribose phosphate catabolic process (GO:0046386)2.23537076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.34868749
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.27525063
3VDR_21846776_ChIP-Seq_THP-1_Human3.22180281
4MYC_22102868_ChIP-Seq_BL_Human2.90197328
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69976010
6E2F7_22180533_ChIP-Seq_HELA_Human2.66480208
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50385145
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42725572
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41756944
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39283190
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.33389978
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27396001
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26673602
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.19131746
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.17544186
16MAF_26560356_Chip-Seq_TH1_Human2.11255375
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.09185050
18P68_20966046_ChIP-Seq_HELA_Human1.98144587
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96178681
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90065558
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88906490
22UTX_26944678_Chip-Seq_JUKART_Human1.88906277
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84046331
24VDR_24763502_ChIP-Seq_THP-1_Human1.83320153
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81960889
26LXR_22292898_ChIP-Seq_THP-1_Human1.79583508
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.79326557
28SA1_27219007_Chip-Seq_ERYTHROID_Human1.73643090
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.72211872
30CTCF_27219007_Chip-Seq_ERYTHROID_Human1.71596298
31MYB_26560356_Chip-Seq_TH1_Human1.69515028
32SPI1_23547873_ChIP-Seq_NB4_Human1.69217130
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68357288
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67604439
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.66937257
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65645656
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.63701702
38TCF7_22412390_ChIP-Seq_EML_Mouse1.63319614
39* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.62555613
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62550241
41GATA1_22383799_ChIP-Seq_G1ME_Mouse1.62096272
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61975927
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61509864
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59810940
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58678016
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57089227
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.56772356
48ZNF263_19887448_ChIP-Seq_K562_Human1.55172072
49MYB_26560356_Chip-Seq_TH2_Human1.54749781
50MAF_26560356_Chip-Seq_TH2_Human1.54558775
51SCL_19346495_ChIP-Seq_HPC-7_Human1.54086000
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53548617
53* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51495971
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49736094
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48513467
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.46763784
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45210382
58* SMC4_20622854_ChIP-Seq_HELA_Human1.44821163
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44359496
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42726392
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42346297
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.41423729
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41004443
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39718512
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38570663
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38265205
67ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38169940
68IRF8_27001747_Chip-Seq_BMDM_Mouse1.37688998
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35691273
70* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35657502
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34902276
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.34639213
73KDM2B_26808549_Chip-Seq_DND41_Human1.32940443
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32436829
75* BCL6_27268052_Chip-Seq_Bcells_Human1.32006204
76RXR_22158963_ChIP-Seq_LIVER_Mouse1.31501219
77NCOR1_26117541_ChIP-Seq_K562_Human1.31180074
78CTCF_21964334_Chip-Seq_Bcells_Human1.30501045
79* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27999780
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27620741
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27391318
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27369275
83* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27199118
84FOXM1_23109430_ChIP-Seq_U2OS_Human1.26582785
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25631254
86E2F1_20622854_ChIP-Seq_HELA_Human1.25137054
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.24632894
88CIITA_25753668_ChIP-Seq_RAJI_Human1.24611369
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23893515
90CTCF_27219007_Chip-Seq_Bcells_Human1.23836262
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23509498
92KDM2B_26808549_Chip-Seq_K562_Human1.22911877
93* TET1_21451524_ChIP-Seq_MESCs_Mouse1.22485778
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.22219157
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21947685
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21802104
97CREB1_26743006_Chip-Seq_LNCaP_Human1.21529735
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18594334
99BCOR_27268052_Chip-Seq_Bcells_Human1.18533035
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18472494
101SA1_27219007_Chip-Seq_Bcells_Human1.18019630
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16073735
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15491189
104RUNX_20019798_ChIP-Seq_JUKART_Human1.15272715
105GATA1_22025678_ChIP-Seq_K562_Human1.14924158
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14260494
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14165847
108CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13379630
109* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13302354
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13152992
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13126132
112VDR_23849224_ChIP-Seq_CD4+_Human1.12970014
113MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12509304
114* GABP_19822575_ChIP-Seq_HepG2_Human1.12478602
115CTCF_20526341_ChIP-Seq_ESCs_Human1.12425235
116ETS1_20019798_ChIP-Seq_JURKAT_Human1.12059651
117* FOXP1_21924763_ChIP-Seq_HESCs_Human1.11702192
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11669578
119* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10904552
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10827330
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10803017
122GATA1_19941826_ChIP-Seq_K562_Human1.10565950
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10540788
124RARB_24833708_ChIP-Seq_LIVER_Mouse1.10407035
125SPI1_23127762_ChIP-Seq_K562_Human1.09912623
126GATA1_19941827_ChIP-Seq_MEL_Mouse1.09528229
127KDM2B_26808549_Chip-Seq_JURKAT_Human1.08227428
128RARA_24833708_ChIP-Seq_LIVER_Mouse1.08216546
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08208290
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07880434
131* XRN2_22483619_ChIP-Seq_HELA_Human1.07638149
132* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07636259
133ATF3_27146783_Chip-Seq_COLON_Human1.07469256
134ELF1_20517297_ChIP-Seq_JURKAT_Human1.07181818
135CTCF_26484167_Chip-Seq_Bcells_Mouse1.06920930
136MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06867282
137CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06675589
138* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06400650
139TFEB_21752829_ChIP-Seq_HELA_Human1.06335568
140* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05938986
141NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04735962
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04650203
143RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03494779
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02946444
145PHF8_20622854_ChIP-Seq_HELA_Human1.02704169
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02082071
147RACK7_27058665_Chip-Seq_MCF-7_Human1.01174680
148SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01161658
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00838709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.29935700
2MP0000685_abnormal_immune_system3.51854763
3MP0001835_abnormal_antigen_presentation3.34191711
4MP0009278_abnormal_bone_marrow2.87523917
5MP0003763_abnormal_thymus_physiology2.83422912
6MP0002166_altered_tumor_susceptibility2.69459510
7MP0008260_abnormal_autophagy2.64123957
8MP0002396_abnormal_hematopoietic_system2.60048691
9* MP0001800_abnormal_humoral_immune2.59005030
10MP0005671_abnormal_response_to2.49326405
11MP0005397_hematopoietic_system_phenotyp2.48557316
12MP0001545_abnormal_hematopoietic_system2.48557316
13MP0008057_abnormal_DNA_replication2.47018042
14MP0003436_decreased_susceptibility_to2.40487932
15MP0009785_altered_susceptibility_to2.35011446
16MP0005387_immune_system_phenotype2.34639696
17MP0001790_abnormal_immune_system2.34639696
18* MP0002398_abnormal_bone_marrow2.26171357
19* MP0002452_abnormal_antigen_presenting2.21734921
20* MP0002723_abnormal_immune_serum2.16537943
21MP0005000_abnormal_immune_tolerance2.12642243
22* MP0002420_abnormal_adaptive_immunity2.10789776
23* MP0000689_abnormal_spleen_morphology2.08551101
24MP0005464_abnormal_platelet_physiology2.08506788
25* MP0001819_abnormal_immune_cell2.07404681
26MP0003705_abnormal_hypodermis_morpholog2.05404496
27* MP0002405_respiratory_system_inflammati2.04774118
28MP0005025_abnormal_response_to2.03659339
29MP0005174_abnormal_tail_pigmentation1.97888757
30MP0002006_tumorigenesis1.97423033
31MP0003806_abnormal_nucleotide_metabolis1.96410346
32* MP0000716_abnormal_immune_system1.96231466
33MP0009333_abnormal_splenocyte_physiolog1.95612716
34MP0005058_abnormal_lysosome_morphology1.89707077
35* MP0002722_abnormal_immune_system1.86205840
36MP0010155_abnormal_intestine_physiology1.85869375
37MP0005670_abnormal_white_adipose1.83389493
38MP0002419_abnormal_innate_immunity1.82071170
39MP0000678_abnormal_parathyroid_gland1.78272055
40* MP0002429_abnormal_blood_cell1.74960281
41MP0002148_abnormal_hypersensitivity_rea1.73504383
42MP0000751_myopathy1.65616253
43MP0004858_abnormal_nervous_system1.62442877
44MP0003172_abnormal_lysosome_physiology1.59774996
45MP0003656_abnormal_erythrocyte_physiolo1.59320962
46MP0000703_abnormal_thymus_morphology1.59205695
47MP0002009_preneoplasia1.58375255
48MP0005365_abnormal_bile_salt1.56596565
49MP0006082_CNS_inflammation1.56445488
50MP0003866_abnormal_defecation1.55820353
51* MP0001845_abnormal_inflammatory_respons1.54510383
52MP0000490_abnormal_crypts_of1.52613927
53MP0001853_heart_inflammation1.47842727
54MP0005666_abnormal_adipose_tissue1.41120754
55MP0005085_abnormal_gallbladder_physiolo1.40383199
56MP0004808_abnormal_hematopoietic_stem1.39368019
57MP0005075_abnormal_melanosome_morpholog1.38027608
58MP0001849_ear_inflammation1.37654255
59MP0010094_abnormal_chromosome_stability1.36429349
60MP0005375_adipose_tissue_phenotype1.36231932
61MP0003303_peritoneal_inflammation1.35479950
62MP0003279_aneurysm1.34464249
63MP0008469_abnormal_protein_level1.33748965
64MP0002019_abnormal_tumor_incidence1.32891861
65MP0000750_abnormal_muscle_regeneration1.32220340
66MP0000003_abnormal_adipose_tissue1.30504518
67MP0005501_abnormal_skin_physiology1.29853265
68MP0000465_gastrointestinal_hemorrhage1.29343621
69* MP0001873_stomach_inflammation1.28579951
70MP0003300_gastrointestinal_ulcer1.26098903
71MP0005410_abnormal_fertilization1.25347627
72MP0006036_abnormal_mitochondrial_physio1.25226137
73MP0005083_abnormal_biliary_tract1.24981747
74MP0003329_amyloid_beta_deposits1.24726943
75MP0003075_altered_response_to1.23226528
76MP0003724_increased_susceptibility_to1.22685715
77* MP0004947_skin_inflammation1.20718981
78MP0004185_abnormal_adipocyte_glucose1.15759592
79MP0000015_abnormal_ear_pigmentation1.14723246
80MP0005360_urolithiasis1.13496200
81MP0009840_abnormal_foam_cell1.12027095
82MP0005330_cardiomyopathy1.11903871
83MP0008058_abnormal_DNA_repair1.10557014
84MP0000609_abnormal_liver_physiology1.08251303
85MP0003566_abnormal_cell_adhesion1.07282430
86MP0010352_gastrointestinal_tract_polyps1.06145476
87MP0000371_diluted_coat_color1.05559577
88MP0004510_myositis1.02994341
89MP0002796_impaired_skin_barrier1.02177766
90MP0005166_decreased_susceptibility_to1.01354943
91MP0003191_abnormal_cellular_cholesterol0.99640683
92MP0000681_abnormal_thyroid_gland0.98566397
93MP0005076_abnormal_cell_differentiation0.98088922
94MP0003111_abnormal_nucleus_morphology0.96382034
95MP0000858_altered_metastatic_potential0.94923798
96MP0008874_decreased_physiological_sensi0.94148277
97MP0002332_abnormal_exercise_endurance0.94117196
98MP0005390_skeleton_phenotype0.93679968
99MP0004381_abnormal_hair_follicle0.91669337
100MP0004957_abnormal_blastocyst_morpholog0.89669082
101MP0002249_abnormal_larynx_morphology0.89358282
102MP0000313_abnormal_cell_death0.89240621
103MP0000749_muscle_degeneration0.89191552
104MP0000604_amyloidosis0.88904721
105* MP0000598_abnormal_liver_morphology0.88407340
106MP0003693_abnormal_embryo_hatching0.87814827
107* MP0002933_joint_inflammation0.87713123
108MP0002998_abnormal_bone_remodeling0.87198818
109MP0009764_decreased_sensitivity_to0.86685513
110MP0000759_abnormal_skeletal_muscle0.86671789
111MP0002653_abnormal_ependyma_morphology0.85875844
112MP0005319_abnormal_enzyme/_coenzyme0.85397386
113MP0001533_abnormal_skeleton_physiology0.82991104
114* MP0009931_abnormal_skin_appearance0.82045252
115MP0002132_abnormal_respiratory_system0.80837693
116MP0003077_abnormal_cell_cycle0.80359897
117MP0000747_muscle_weakness0.79755227
118MP0002138_abnormal_hepatobiliary_system0.78971691
119MP0002139_abnormal_hepatobiliary_system0.78786954
120MP0000343_altered_response_to0.77739507
121* MP0003453_abnormal_keratinocyte_physiol0.76347945
122MP0000013_abnormal_adipose_tissue0.75993992
123MP0001666_abnormal_nutrient_absorption0.75978164
124MP0004233_abnormal_muscle_weight0.75093587
125MP0005023_abnormal_wound_healing0.74810732
126MP0000249_abnormal_blood_vessel0.74179696
127MP0003186_abnormal_redox_activity0.72547800
128MP0010307_abnormal_tumor_latency0.72192998
129MP0003045_fibrosis0.71533683
130MP0002269_muscular_atrophy0.71194902
131MP0003943_abnormal_hepatobiliary_system0.70617776
132MP0003183_abnormal_peptide_metabolism0.69134359
133MP0002928_abnormal_bile_duct0.68870597
134MP0003448_altered_tumor_morphology0.68221766
135MP0009763_increased_sensitivity_to0.65443741
136MP0005584_abnormal_enzyme/coenzyme_acti0.65178732
137MP0009115_abnormal_fat_cell0.65000632
138MP0003828_pulmonary_edema0.63911660
139MP0005310_abnormal_salivary_gland0.63572001
140MP0002970_abnormal_white_adipose0.63320885

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.50474769
2IgM deficiency (HP:0002850)4.67721090
3Poikiloderma (HP:0001029)4.04487070
4Increased IgM level (HP:0003496)3.90821073
5Recurrent fungal infections (HP:0002841)3.73403596
6Abnormality of the heme biosynthetic pathway (HP:0010472)3.67830085
7Recurrent bronchitis (HP:0002837)3.63101029
8IgA deficiency (HP:0002720)3.62337337
9Recurrent abscess formation (HP:0002722)3.45743955
10Abnormality of T cell physiology (HP:0011840)3.41958853
11IgG deficiency (HP:0004315)3.37540933
12Colitis (HP:0002583)3.33596648
13Gastrointestinal inflammation (HP:0004386)3.31081885
14Eczematoid dermatitis (HP:0000976)3.30104669
15Inflammation of the large intestine (HP:0002037)3.28620689
16Abnormality of T cells (HP:0002843)3.24759375
17Panhypogammaglobulinemia (HP:0003139)3.23917138
18Recurrent viral infections (HP:0004429)3.23300262
19Distal lower limb muscle weakness (HP:0009053)3.21539956
20Mucopolysacchariduria (HP:0008155)3.20902227
21Urinary glycosaminoglycan excretion (HP:0003541)3.20902227
22Dysostosis multiplex (HP:0000943)3.17317041
23Agammaglobulinemia (HP:0004432)3.11747973
24Purpura (HP:0000979)3.09590636
25Recurrent bacterial skin infections (HP:0005406)3.07190247
26Elevated erythrocyte sedimentation rate (HP:0003565)3.06569276
27Increased serum ferritin (HP:0003281)3.05874005
28Abnormality of mucopolysaccharide metabolism (HP:0011020)3.01190350
29Abnormality of polysaccharide metabolism (HP:0011012)3.01190350
30Abnormality of glycosaminoglycan metabolism (HP:0004371)3.01190350
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.01091451
32Chronic obstructive pulmonary disease (HP:0006510)2.98224555
33Obstructive lung disease (HP:0006536)2.98224555
34Myopathic facies (HP:0002058)2.95709126
35Vertebral compression fractures (HP:0002953)2.94318419
36Petechiae (HP:0000967)2.91596648
37Albinism (HP:0001022)2.90596584
38Chronic otitis media (HP:0000389)2.90191379
39Thrombocytosis (HP:0001894)2.89681549
40Vacuolated lymphocytes (HP:0001922)2.87394552
41Bulbar palsy (HP:0001283)2.84260339
42Myositis (HP:0100614)2.82281011
43Meningitis (HP:0001287)2.81708456
44Squamous cell carcinoma (HP:0002860)2.80003455
45Hypertensive crisis (HP:0100735)2.71958298
46Prolonged bleeding time (HP:0003010)2.71619044
47Reticulocytosis (HP:0001923)2.71303481
48Ragged-red muscle fibers (HP:0003200)2.67729462
49Abnormality of T cell number (HP:0011839)2.64071909
50T lymphocytopenia (HP:0005403)2.63401912
51Lymphoma (HP:0002665)2.57241586
52Recurrent cutaneous fungal infections (HP:0011370)2.56060693
53Chronic mucocutaneous candidiasis (HP:0002728)2.56060693
54Cellulitis (HP:0100658)2.55566242
55Severe combined immunodeficiency (HP:0004430)2.53607800
56Autoimmune thrombocytopenia (HP:0001973)2.52442887
57Increased connective tissue (HP:0009025)2.50800281
58Abnormality of B cell number (HP:0010975)2.50195773
59B lymphocytopenia (HP:0010976)2.50195773
60Centrally nucleated skeletal muscle fibers (HP:0003687)2.50039865
61Gastrointestinal stroma tumor (HP:0100723)2.49947132
62Recurrent gram-negative bacterial infections (HP:0005420)2.48351263
63Abnormality of cells of the lymphoid lineage (HP:0012140)2.46567627
64Recurrent skin infections (HP:0001581)2.45045835
65Cheilitis (HP:0100825)2.43948487
66Distal lower limb amyotrophy (HP:0008944)2.43440570
67Epistaxis (HP:0000421)2.41938588
68Basal cell carcinoma (HP:0002671)2.41719742
69Lymphopenia (HP:0001888)2.41254715
70Hypertriglyceridemia (HP:0002155)2.40969255
71Hypochromic anemia (HP:0001931)2.40421307
72Hypergammaglobulinemia (HP:0010702)2.40416853
73Increased cerebral lipofuscin (HP:0011813)2.40056180
74Abnormality of iron homeostasis (HP:0011031)2.39343758
75Nasal polyposis (HP:0100582)2.38448068
76Combined immunodeficiency (HP:0005387)2.38058327
77Polycythemia (HP:0001901)2.37668946
78Abnormal gallbladder physiology (HP:0012438)2.37030134
79Cholecystitis (HP:0001082)2.37030134
80Cholelithiasis (HP:0001081)2.36814825
81Mediastinal lymphadenopathy (HP:0100721)2.35665787
82Abnormality of the nasal mucosa (HP:0000433)2.33645956
83Papilloma (HP:0012740)2.33351049
84Verrucae (HP:0200043)2.33351049
85Abnormal platelet volume (HP:0011876)2.32675336
86Asymmetric septal hypertrophy (HP:0001670)2.32273322
87Abnormality of glycolipid metabolism (HP:0010969)2.30289489
88Abnormality of liposaccharide metabolism (HP:0010968)2.30289489
89Abnormality of glycosphingolipid metabolism (HP:0004343)2.30289489
90Joint stiffness (HP:0001387)2.29899098
91Loss of speech (HP:0002371)2.29404111
92Upper limb amyotrophy (HP:0009129)2.28035126
93Distal upper limb amyotrophy (HP:0007149)2.28035126
94Vasculitis (HP:0002633)2.26613261
95Hemorrhage of the eye (HP:0011885)2.26299045
96Exercise-induced myalgia (HP:0003738)2.25971945
97Easy fatigability (HP:0003388)2.25763416
98Cervical subluxation (HP:0003308)2.25695392
99Thyroiditis (HP:0100646)2.25424721
100Increased neuronal autofluorescent lipopigment (HP:0002074)2.25197076
101Spontaneous hematomas (HP:0007420)2.24042090
102Stridor (HP:0010307)2.22476506
103Cerebral palsy (HP:0100021)2.18062415
104Hepatosplenomegaly (HP:0001433)2.16796744
105Recurrent sinusitis (HP:0011108)2.16510816
106Axonal loss (HP:0003447)2.13726610
107Annular pancreas (HP:0001734)2.13626553
108Abnormality of male internal genitalia (HP:0000022)2.12610097
109Ulnar bowing (HP:0003031)2.12503911
110Abnormality of aromatic amino acid family metabolism (HP:0004338)2.12162322
111Tongue fasciculations (HP:0001308)2.11822463
112Granulocytopenia (HP:0001913)2.11654284
113Eosinophilia (HP:0001880)2.11611609
114Prolonged neonatal jaundice (HP:0006579)2.10549102
115Growth hormone excess (HP:0000845)2.09739500
116Achilles tendon contracture (HP:0001771)2.09084132
117Abnormality of skeletal muscle fiber size (HP:0012084)2.06225311
118Microcytic anemia (HP:0001935)2.04833429
119Abnormality of macrophages (HP:0004311)2.02940344
120Gingival bleeding (HP:0000225)2.02685119
121Increased IgE level (HP:0003212)2.01293663
122Selective tooth agenesis (HP:0001592)2.01074395
123Increased variability in muscle fiber diameter (HP:0003557)2.00516562
124Thin bony cortex (HP:0002753)2.00269646
125Abnormality of eosinophils (HP:0001879)1.98654597
126Difficulty climbing stairs (HP:0003551)1.97926353
127Abnormal platelet function (HP:0011869)1.97605741
128Impaired platelet aggregation (HP:0003540)1.97605741
129Male infertility (HP:0003251)1.95943640
130Hyperthyroidism (HP:0000836)1.95906027
131Polygenic inheritance (HP:0010982)1.95284281
132Recurrent lower respiratory tract infections (HP:0002783)1.95051510
133Interstitial pulmonary disease (HP:0006530)1.94669900
134Increased muscle lipid content (HP:0009058)1.94444128
135Atelectasis (HP:0100750)1.94138577
136Rhabdomyolysis (HP:0003201)1.93973143
137Bronchitis (HP:0012387)1.93901479
138Aplastic anemia (HP:0001915)1.93828031
139Progressive neurologic deterioration (HP:0002344)1.93601953
140Reticulocytopenia (HP:0001896)1.92608906
141Emphysema (HP:0002097)1.92109597
142Abnormality of the Achilles tendon (HP:0005109)1.91719117
143Muscle fibrillation (HP:0010546)1.90972323
144Recurrent otitis media (HP:0000403)1.90702338
145Joint swelling (HP:0001386)1.90687949
146Increased mean platelet volume (HP:0011877)1.89864905
147Abnormal gallbladder morphology (HP:0012437)1.88806287
148Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88730430
149Hypoplasia of the thymus (HP:0000778)1.88584358
150Amyloidosis (HP:0011034)1.88392031
151Gastrointestinal infarctions (HP:0005244)1.88265029
152Premature graying of hair (HP:0002216)1.88264419
153Menorrhagia (HP:0000132)1.86751422
154Flattened epiphyses (HP:0003071)1.85879871
155Leukocytosis (HP:0001974)1.85343760
156Abnormality of transition element cation homeostasis (HP:0011030)1.83729307
157Seborrheic dermatitis (HP:0001051)1.83404606
158J-shaped sella turcica (HP:0002680)1.83165768
159Gastrointestinal dysmotility (HP:0002579)1.83099344
160Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80844894
161Truncus arteriosus (HP:0001660)1.80707279
162Systemic lupus erythematosus (HP:0002725)1.80366423
163Thoracic kyphosis (HP:0002942)1.79818027
164Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79097066
165Hand muscle atrophy (HP:0009130)1.76774405
166Abnormality of reticulocytes (HP:0004312)1.76689464
167Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76474873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.08600168
2MAP3K113.25463217
3TESK13.15261056
4ERN12.95166221
5MAPK152.80287479
6SMG12.78258564
7ICK2.50395691
8MAP3K62.46419846
9VRK22.35482877
10CSK2.34321584
11PRPF4B2.19652792
12TYK22.12052043
13MAP3K102.10964284
14MATK2.09991042
15TAOK22.05876523
16PIM22.05511362
17BLK1.96705192
18ZAP701.90639249
19TBK11.87870864
20KIT1.87535200
21BTK1.74138030
22FLT31.71293969
23JAK31.70470745
24PINK11.69336213
25MAP3K31.62422938
26EPHA21.59750023
27DYRK1B1.58642630
28IKBKE1.58341188
29ARAF1.58234514
30GRK61.58070671
31PIM11.52287202
32TXK1.52005025
33TRIB31.49512068
34SYK1.47455007
35FGFR41.44095658
36STK101.38215592
37NME21.34776690
38MAPK111.30561706
39IRAK41.30291733
40DAPK11.27880881
41KDR1.27060422
42TTN1.26093063
43BCKDK1.22159461
44DDR21.20769294
45CSF1R1.20664183
46LYN1.19364413
47MAP3K11.19267220
48PRKD21.18178724
49LCK1.17485919
50JAK11.12997249
51SIK31.12577043
52EEF2K1.10836090
53LRRK21.09547203
54ACVR1B1.08834344
55MST1R1.08425220
56PRKD31.07044548
57TEC1.06411905
58TESK21.06121645
59TRPM71.05199765
60FGR1.05090113
61SIK21.02856272
62IRAK31.02667211
63ITK1.02374785
64PKN21.00678260
65YES11.00226662
66ABL20.99116069
67IKBKB0.98027409
68SIK10.97055901
69BMX0.93577714
70TNK20.90694427
71CDK70.87510049
72RIPK10.87248355
73PDPK10.86617019
74MARK20.84131132
75RPS6KL10.84109770
76RPS6KC10.84109770
77PAK40.83957565
78RPS6KA60.83777485
79HIPK20.83241864
80ATR0.81099097
81MAP3K130.80129174
82MAPKAPK30.79989528
83MAP3K140.79237634
84LIMK10.79100070
85HCK0.77807125
86CDK60.77413312
87FES0.76483863
88TAOK10.75721895
89TAOK30.75416403
90CDC42BPA0.75020231
91PTK60.74492653
92ILK0.73756491
93MAPK120.72867630
94NEK20.72115044
95EPHB10.67575795
96DAPK30.67035511
97JAK20.66951568
98LMTK20.66494396
99RPS6KB20.66204275
100TLK10.66168508
101MAP2K30.64983484
102FGFR30.64657554
103MAP2K20.64063514
104BRAF0.63346724
105RPS6KA20.63038538
106IRAK20.61344387
107DYRK30.60487686
108CDK40.59933702
109MARK30.58058608
110RPS6KA40.55566657
111TGFBR20.55322974
112PRKG20.55238036
113TGFBR10.54845335
114MAPKAPK20.53761316
115SCYL20.53713471
116CHUK0.53354489
117TYRO30.52753957
118UHMK10.52716096
119STK40.51672194
120STK380.50938612
121EIF2AK10.50850689
122MAPK40.49805391
123RIPK40.49726601
124MAP3K70.49126042
125PAK10.48747160
126PDK10.47084051
127PRKD10.46360230
128EIF2AK30.45197517
129MTOR0.44676528
130STK160.43446547
131NLK0.43191721
132MAP3K80.42967883
133RAF10.42798358
134AURKA0.41782293
135PRKCD0.41587192
136MAP2K60.41481966
137MAPK30.41126484
138GRK50.38564277
139PDGFRA0.35086224
140PTK20.33209455
141CHEK20.31564643
142RPS6KA10.31449546
143PTK2B0.30793331

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.36561567
2Base excision repair_Homo sapiens_hsa034103.40836600
3DNA replication_Homo sapiens_hsa030303.30076919
4Mismatch repair_Homo sapiens_hsa034303.23580509
5B cell receptor signaling pathway_Homo sapiens_hsa046622.25254219
6Sulfur relay system_Homo sapiens_hsa041221.90423203
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.85055461
8Measles_Homo sapiens_hsa051621.82977014
9Ribosome_Homo sapiens_hsa030101.79573866
10Antigen processing and presentation_Homo sapiens_hsa046121.75133071
11Folate biosynthesis_Homo sapiens_hsa007901.72069407
12Leishmaniasis_Homo sapiens_hsa051401.62773688
13Shigellosis_Homo sapiens_hsa051311.60479903
14Homologous recombination_Homo sapiens_hsa034401.60348630
15Herpes simplex infection_Homo sapiens_hsa051681.57835990
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56887297
17p53 signaling pathway_Homo sapiens_hsa041151.54257851
18Hematopoietic cell lineage_Homo sapiens_hsa046401.53513412
19Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.52456454
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51944719
21Fatty acid biosynthesis_Homo sapiens_hsa000611.48863156
22Nucleotide excision repair_Homo sapiens_hsa034201.46544617
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.41320579
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.41118134
25Legionellosis_Homo sapiens_hsa051341.35906974
26Acute myeloid leukemia_Homo sapiens_hsa052211.32195079
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31458798
28Endocytosis_Homo sapiens_hsa041441.27092569
29Staphylococcus aureus infection_Homo sapiens_hsa051501.25337583
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24460771
31Malaria_Homo sapiens_hsa051441.23735970
32Osteoclast differentiation_Homo sapiens_hsa043801.22999668
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22543929
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20366401
35Non-small cell lung cancer_Homo sapiens_hsa052231.14057842
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.11492369
37Spliceosome_Homo sapiens_hsa030401.11391849
38Notch signaling pathway_Homo sapiens_hsa043301.11318845
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10860172
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10641054
41Viral myocarditis_Homo sapiens_hsa054161.07058876
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.04081101
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03721983
44Hepatitis B_Homo sapiens_hsa051611.03453742
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02946463
46Glutathione metabolism_Homo sapiens_hsa004801.01580852
47Apoptosis_Homo sapiens_hsa042101.00876322
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00321129
49T cell receptor signaling pathway_Homo sapiens_hsa046601.00181748
50Phenylalanine metabolism_Homo sapiens_hsa003601.00112905
51Hepatitis C_Homo sapiens_hsa051600.98536254
52Allograft rejection_Homo sapiens_hsa053300.98052556
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97519032
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.96794138
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95223949
56Other glycan degradation_Homo sapiens_hsa005110.94267710
57Fanconi anemia pathway_Homo sapiens_hsa034600.93641882
58Non-homologous end-joining_Homo sapiens_hsa034500.92547637
59Selenocompound metabolism_Homo sapiens_hsa004500.92053308
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91320515
61Caffeine metabolism_Homo sapiens_hsa002320.91316029
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.91240231
63Lysine degradation_Homo sapiens_hsa003100.90488586
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.88731741
65Carbon metabolism_Homo sapiens_hsa012000.87907264
66Influenza A_Homo sapiens_hsa051640.87765054
67Biosynthesis of amino acids_Homo sapiens_hsa012300.86508562
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.85321288
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83965744
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83843899
71Lysosome_Homo sapiens_hsa041420.81895078
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80097755
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78595939
74Viral carcinogenesis_Homo sapiens_hsa052030.76705210
75Epstein-Barr virus infection_Homo sapiens_hsa051690.75763753
76Arginine biosynthesis_Homo sapiens_hsa002200.73326854
77TNF signaling pathway_Homo sapiens_hsa046680.73157021
78Phagosome_Homo sapiens_hsa041450.73005516
79Chronic myeloid leukemia_Homo sapiens_hsa052200.72921025
80N-Glycan biosynthesis_Homo sapiens_hsa005100.72810132
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.71905557
82Fructose and mannose metabolism_Homo sapiens_hsa000510.71865551
83mTOR signaling pathway_Homo sapiens_hsa041500.71526680
84Tuberculosis_Homo sapiens_hsa051520.70511485
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.69667787
86Galactose metabolism_Homo sapiens_hsa000520.69563122
87Insulin signaling pathway_Homo sapiens_hsa049100.69265094
88Vibrio cholerae infection_Homo sapiens_hsa051100.68743039
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.68505219
90Chemokine signaling pathway_Homo sapiens_hsa040620.68283929
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.67936812
92Prion diseases_Homo sapiens_hsa050200.67696789
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63809892
94Toxoplasmosis_Homo sapiens_hsa051450.63708255
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63237517
96Autoimmune thyroid disease_Homo sapiens_hsa053200.62295751
97Pyrimidine metabolism_Homo sapiens_hsa002400.62099824
98Arginine and proline metabolism_Homo sapiens_hsa003300.61111165
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59626647
100AMPK signaling pathway_Homo sapiens_hsa041520.59464854
101Pentose phosphate pathway_Homo sapiens_hsa000300.59131680
102Tryptophan metabolism_Homo sapiens_hsa003800.58942276
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58883855
104Pertussis_Homo sapiens_hsa051330.58795071
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58162543
106VEGF signaling pathway_Homo sapiens_hsa043700.57928812
107Graft-versus-host disease_Homo sapiens_hsa053320.57686129
108Proteasome_Homo sapiens_hsa030500.57382500
109RNA transport_Homo sapiens_hsa030130.57115876
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54759470
111Insulin resistance_Homo sapiens_hsa049310.54517657
112One carbon pool by folate_Homo sapiens_hsa006700.53061561
113ABC transporters_Homo sapiens_hsa020100.52228668
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51907601
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51137834
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.50839502
117Salmonella infection_Homo sapiens_hsa051320.49217654
118Cell cycle_Homo sapiens_hsa041100.48842978
119Fatty acid metabolism_Homo sapiens_hsa012120.48317078
120Sulfur metabolism_Homo sapiens_hsa009200.47233039
121Pancreatic cancer_Homo sapiens_hsa052120.47152429
122Systemic lupus erythematosus_Homo sapiens_hsa053220.46186614
123HTLV-I infection_Homo sapiens_hsa051660.45304829
124Bladder cancer_Homo sapiens_hsa052190.44891378
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44660426
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43548644
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42228326
128Amoebiasis_Homo sapiens_hsa051460.41811456
129Platelet activation_Homo sapiens_hsa046110.41133931
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40723427
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40678815
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40626076
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39587001
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39370507

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