SHB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.54806635
2L-phenylalanine catabolic process (GO:0006559)6.54806635
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.46597267
4L-phenylalanine metabolic process (GO:0006558)6.46597267
5aromatic amino acid family catabolic process (GO:0009074)5.79135484
6glyoxylate metabolic process (GO:0046487)5.31954112
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.29842699
8cysteine metabolic process (GO:0006534)5.26984869
9kynurenine metabolic process (GO:0070189)5.26919293
10tryptophan catabolic process (GO:0006569)5.15468117
11indole-containing compound catabolic process (GO:0042436)5.15468117
12indolalkylamine catabolic process (GO:0046218)5.15468117
13urea metabolic process (GO:0019627)5.08630251
14urea cycle (GO:0000050)5.08630251
15sulfur amino acid catabolic process (GO:0000098)5.07909091
16lysine metabolic process (GO:0006553)5.05592324
17lysine catabolic process (GO:0006554)5.05592324
18negative regulation of fibrinolysis (GO:0051918)5.02466523
19peptidyl-glutamic acid carboxylation (GO:0017187)4.90431122
20protein carboxylation (GO:0018214)4.90431122
21tryptophan metabolic process (GO:0006568)4.86858114
22bile acid biosynthetic process (GO:0006699)4.86353830
23alpha-linolenic acid metabolic process (GO:0036109)4.73624657
24nitrogen cycle metabolic process (GO:0071941)4.65176661
25serine family amino acid catabolic process (GO:0009071)4.62739086
26regulation of fibrinolysis (GO:0051917)4.60786176
27desmosome organization (GO:0002934)4.58106893
28high-density lipoprotein particle remodeling (GO:0034375)4.56351046
29skin morphogenesis (GO:0043589)4.49542879
30complement activation, alternative pathway (GO:0006957)4.49043112
31regulation of protein activation cascade (GO:2000257)4.46179080
32homocysteine metabolic process (GO:0050667)4.44661866
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.43655263
34amino-acid betaine metabolic process (GO:0006577)4.37261199
35regulation of cholesterol homeostasis (GO:2000188)4.32917964
36regulation of triglyceride catabolic process (GO:0010896)4.27016206
37hemidesmosome assembly (GO:0031581)4.26630630
38phospholipid efflux (GO:0033700)4.23651575
39Golgi transport vesicle coating (GO:0048200)4.21246766
40COPI coating of Golgi vesicle (GO:0048205)4.21246766
41bile acid metabolic process (GO:0008206)4.20268696
42triglyceride homeostasis (GO:0070328)4.19127289
43acylglycerol homeostasis (GO:0055090)4.19127289
44protein localization to endosome (GO:0036010)4.18991769
45regulation of complement activation (GO:0030449)4.17035978
46aromatic amino acid family metabolic process (GO:0009072)4.16673460
47cell adhesion mediated by integrin (GO:0033627)4.09942675
48reverse cholesterol transport (GO:0043691)4.07376159
49alpha-amino acid catabolic process (GO:1901606)4.05424204
50negative regulation of cholesterol transport (GO:0032375)3.99780591
51negative regulation of sterol transport (GO:0032372)3.99780591
52epithelial cell-cell adhesion (GO:0090136)3.98454086
53tyrosine metabolic process (GO:0006570)3.94948823
54cellular modified amino acid catabolic process (GO:0042219)3.86203737
55regulation of cholesterol esterification (GO:0010872)3.85122861
56glutamate metabolic process (GO:0006536)3.78929862
57bile acid and bile salt transport (GO:0015721)3.78437804
58glycine metabolic process (GO:0006544)3.77882024
59cellular amino acid catabolic process (GO:0009063)3.77777204
60plasma lipoprotein particle clearance (GO:0034381)3.76635804
61plasma lipoprotein particle remodeling (GO:0034369)3.75912771
62protein-lipid complex remodeling (GO:0034368)3.75912771
63macromolecular complex remodeling (GO:0034367)3.75912771
64serine family amino acid metabolic process (GO:0009069)3.75325689
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.74991825
66protein retention in ER lumen (GO:0006621)3.70707680
67cellular ketone body metabolic process (GO:0046950)3.69222222
68coenzyme catabolic process (GO:0009109)3.68014923
69drug catabolic process (GO:0042737)3.66818260
70regulation of bile acid biosynthetic process (GO:0070857)3.65538644
71imidazole-containing compound metabolic process (GO:0052803)3.62831820
72cellular glucuronidation (GO:0052695)3.59851860
73arginine metabolic process (GO:0006525)3.58402448
74cell-substrate junction assembly (GO:0007044)3.57165492
75intestinal cholesterol absorption (GO:0030299)3.56525008
76fatty acid beta-oxidation (GO:0006635)3.56193425
77aspartate family amino acid catabolic process (GO:0009068)3.56036114
78positive regulation of fatty acid beta-oxidation (GO:0032000)3.55616571
79fibrinolysis (GO:0042730)3.55230985
80indolalkylamine metabolic process (GO:0006586)3.54194074
81cholesterol efflux (GO:0033344)3.52730281
82phospholipid homeostasis (GO:0055091)3.50078640
83benzene-containing compound metabolic process (GO:0042537)3.49761356
84dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.48298583
85urate metabolic process (GO:0046415)3.48088530
86drug transmembrane transport (GO:0006855)3.47050782
87fatty acid oxidation (GO:0019395)3.45899820
88negative regulation of fatty acid biosynthetic process (GO:0045717)3.45390541
89flavonoid metabolic process (GO:0009812)3.43659054
90basement membrane organization (GO:0071711)3.43184628
91planar cell polarity pathway involved in neural tube closure (GO:0090179)3.42058133
92plasma lipoprotein particle assembly (GO:0034377)3.41571505
93acetyl-CoA metabolic process (GO:0006084)3.41254260
942-oxoglutarate metabolic process (GO:0006103)3.40068644
95cholesterol homeostasis (GO:0042632)3.39957484
96ethanol oxidation (GO:0006069)3.38516133
97positive regulation of lipid catabolic process (GO:0050996)3.38312017
98sterol homeostasis (GO:0055092)3.37679254
99lipid oxidation (GO:0034440)3.36755905
100organic acid catabolic process (GO:0016054)3.36150142
101carboxylic acid catabolic process (GO:0046395)3.36150142
102carnitine metabolic process (GO:0009437)3.35877026
103negative regulation of lipase activity (GO:0060192)3.34721587
104dicarboxylic acid biosynthetic process (GO:0043650)3.33697355
105positive regulation of triglyceride lipase activity (GO:0061365)3.33013433
106positive regulation of lipoprotein lipase activity (GO:0051006)3.33013433
107fatty acid catabolic process (GO:0009062)3.31601652
108adherens junction assembly (GO:0034333)3.29962990
109regulation of early endosome to late endosome transport (GO:2000641)3.29641772
110short-chain fatty acid metabolic process (GO:0046459)3.28845135
111monocarboxylic acid catabolic process (GO:0072329)3.28445898
112positive regulation of extracellular matrix organization (GO:1903055)3.28246721
113response to mercury ion (GO:0046689)3.26788530
114serine family amino acid biosynthetic process (GO:0009070)3.26558867
115cellular biogenic amine catabolic process (GO:0042402)3.25425134
116amine catabolic process (GO:0009310)3.25425134
117lipoprotein metabolic process (GO:0042157)3.24279095
118regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.24030127
119regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.22959995
120regulation of apoptotic process involved in morphogenesis (GO:1902337)3.20146614
121substrate-dependent cell migration (GO:0006929)3.19027228
122semaphorin-plexin signaling pathway (GO:0071526)3.17993592
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.15566460
124cell-substrate adherens junction assembly (GO:0007045)3.14977847
125focal adhesion assembly (GO:0048041)3.14977847
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.12961180
127endodermal cell differentiation (GO:0035987)3.08613954
128peptidyl-proline hydroxylation (GO:0019511)2.97802359
129retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.97464150
130branching involved in mammary gland duct morphogenesis (GO:0060444)2.95966583
131cytoskeletal anchoring at plasma membrane (GO:0007016)2.95023872
132vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.94066224
133negative regulation of fatty acid transport (GO:2000192)2.91002946
134barbed-end actin filament capping (GO:0051016)2.89306265
135regulation of water loss via skin (GO:0033561)2.87837572
136protein hydroxylation (GO:0018126)2.85745795
137pinocytosis (GO:0006907)2.84023120
138endothelial cell morphogenesis (GO:0001886)2.75430520
139gap junction assembly (GO:0016264)2.74604496
140bundle of His cell to Purkinje myocyte communication (GO:0086069)2.74058598
141mesodermal cell differentiation (GO:0048333)2.72985125
142activation of Rac GTPase activity (GO:0032863)2.71793702
143atrioventricular valve morphogenesis (GO:0003181)2.71789087
144apoptotic cell clearance (GO:0043277)2.69563140
145regulation of cardioblast differentiation (GO:0051890)2.68592719
146endothelial cell chemotaxis (GO:0035767)2.67216903
147stress fiber assembly (GO:0043149)2.67183591
148regulation of mammary gland epithelial cell proliferation (GO:0033599)2.66703290
149regulation of plasminogen activation (GO:0010755)2.65305932
150protein maturation by protein folding (GO:0022417)2.62042745
151cell-cell junction maintenance (GO:0045217)2.61408909
152positive regulation of osteoblast proliferation (GO:0033690)2.61395592
153low-density lipoprotein particle clearance (GO:0034383)2.61075919
154positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59019272
155hypotonic response (GO:0006971)2.58742342
156positive regulation of endothelial cell apoptotic process (GO:2000353)2.58572790
157wound healing, spreading of epidermal cells (GO:0035313)2.52095847
158hyaluronan catabolic process (GO:0030214)2.51612046
159glucose 6-phosphate metabolic process (GO:0051156)2.51404426
1604-hydroxyproline metabolic process (GO:0019471)2.49356511
161adhesion of symbiont to host (GO:0044406)2.46440925
162positive regulation of blood vessel endothelial cell migration (GO:0043536)2.45807027
163cochlea morphogenesis (GO:0090103)2.45689075
164Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.44601383
165regulation of transforming growth factor beta1 production (GO:0032908)2.44470899
166embryo implantation (GO:0007566)2.43549412
167activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42849458
168regulation of extracellular matrix organization (GO:1903053)2.42395115
169apoptotic process involved in morphogenesis (GO:0060561)2.42386938
170vascular endothelial growth factor signaling pathway (GO:0038084)2.40800569
171proline biosynthetic process (GO:0006561)2.39291684
172endocytic recycling (GO:0032456)2.37780191
173regulation of extracellular matrix disassembly (GO:0010715)2.37607034
174negative regulation of chondrocyte differentiation (GO:0032331)2.36771543
175positive regulation of Cdc42 GTPase activity (GO:0043089)2.36744083
176establishment of skin barrier (GO:0061436)2.36405361
177regulation of glucose import in response to insulin stimulus (GO:2001273)2.35594424
178negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.35151196
179surfactant homeostasis (GO:0043129)2.34368781
180actin filament bundle organization (GO:0061572)2.33327465
181actin filament bundle assembly (GO:0051017)2.33327465
182regulation of establishment of planar polarity (GO:0090175)2.32713267
183positive regulation of nuclease activity (GO:0032075)2.28748062
184endocardial cushion development (GO:0003197)2.28085695
185wound healing, spreading of cells (GO:0044319)2.27260158
186lung vasculature development (GO:0060426)2.26737985
187retina vasculature morphogenesis in camera-type eye (GO:0061299)2.26224812
188cellular copper ion homeostasis (GO:0006878)2.25840489
189protein localization to microtubule (GO:0035372)2.25833160
190branching involved in salivary gland morphogenesis (GO:0060445)2.25664657
191endoplasmic reticulum unfolded protein response (GO:0030968)2.24702869
192regulation of metalloenzyme activity (GO:0048552)2.24470983
193regulation of transforming growth factor beta2 production (GO:0032909)2.23950418
194diaphragm development (GO:0060539)2.23634824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.16334768
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.63615635
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.90307899
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.24409017
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80346699
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.36868092
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.25601392
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.48931910
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.20106370
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.77359769
11CLOCK_20551151_ChIP-Seq_293T_Human2.50658335
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45416722
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34418909
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.27411369
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.09478525
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99163806
17ZNF263_19887448_ChIP-Seq_K562_Human1.91356453
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90485438
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.76619846
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74452968
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74064091
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72637388
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72398656
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67781985
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66022280
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.63312805
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.63312805
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63132501
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.57499102
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54283066
31* FOXA2_19822575_ChIP-Seq_HepG2_Human1.51730964
32TP53_22127205_ChIP-Seq_IMR90_Human1.51109761
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.49636981
34* UBF1/2_26484160_Chip-Seq_HMECs_Human1.49037321
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43574075
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.41054223
37* RACK7_27058665_Chip-Seq_MCF-7_Human1.40649077
38* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40079091
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37591941
40ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36597934
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35493994
42LXR_22292898_ChIP-Seq_THP-1_Human1.33863016
43AR_21909140_ChIP-Seq_LNCAP_Human1.30575168
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30411545
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.29436412
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.26686124
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26672439
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26348236
49* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26187655
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25508717
51ATF3_27146783_Chip-Seq_COLON_Human1.24844919
52VDR_21846776_ChIP-Seq_THP-1_Human1.23109119
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22990358
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21446354
55* HNF4A_19822575_ChIP-Seq_HepG2_Human1.19806983
56* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19064188
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14093917
58GATA6_25053715_ChIP-Seq_YYC3_Human1.13483090
59GATA4_25053715_ChIP-Seq_YYC3_Human1.10297973
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07861088
61* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06532449
62* TBX20_22080862_ChIP-Seq_HEART_Mouse1.05510804
63* TBX20_22328084_ChIP-Seq_HEART_Mouse1.05510804
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05268510
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05161839
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05149105
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04993317
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03941144
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03161660
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02481888
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.02472397
72* ELK3_25401928_ChIP-Seq_HUVEC_Human1.02012945
73* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01786266
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01251088
75CDX2_20551321_ChIP-Seq_CACO-2_Human1.01120666
76* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00757916
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00298124
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.00016071
79EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99733418
80CREB1_26743006_Chip-Seq_LNCaP_Human0.99689660
81SA1_27219007_Chip-Seq_ERYTHROID_Human0.98836237
82* SMC4_20622854_ChIP-Seq_HELA_Human0.98349550
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98185380
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98087549
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97881171
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96857178
87P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96645455
88P68_20966046_ChIP-Seq_HELA_Human0.95422792
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94073106
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92308319
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91375984
92* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91150392
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88996727
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88812532
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88183012
96RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87425274
97* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87127368
98TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86568186
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85134936
100* KDM2B_26808549_Chip-Seq_K562_Human0.84389752
101* RUNX1_27514584_Chip-Seq_MCF-7_Human0.84004571
102* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83311574
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83043106
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82784281
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79412474
106GATA1_19941826_ChIP-Seq_K562_Human0.78655378
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77892117
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76974654
109SOX2_20726797_ChIP-Seq_SW620_Human0.76606982
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75740125
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75089753
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74248521
113GATA3_24758297_ChIP-Seq_MCF-7_Human0.73723311
114KDM2B_26808549_Chip-Seq_DND41_Human0.73686774
115SOX9_24532713_ChIP-Seq_HFSC_Mouse0.73347548
116P63_26484246_Chip-Seq_KERATINOCYTES_Human0.73291111
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.72910160
118GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72078307
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71257073
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.71086420
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.70865409
122* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.69945151
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69893054
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.69246274
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68119174
126TCF7_22412390_ChIP-Seq_EML_Mouse0.67827538
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.67547596
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.66579953
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.65592175
130* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.65022900
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64454879
132* TP63_22573176_ChIP-Seq_HFKS_Human0.63487871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.86484519
2MP0005360_urolithiasis6.63421295
3MP0005085_abnormal_gallbladder_physiolo5.50159801
4MP0005365_abnormal_bile_salt5.08455475
5MP0008875_abnormal_xenobiotic_pharmacok3.96167767
6MP0008438_abnormal_cutaneous_collagen3.83071782
7MP0003252_abnormal_bile_duct3.42548857
8MP0003806_abnormal_nucleotide_metabolis3.33764463
9MP0010329_abnormal_lipoprotein_level2.99278399
10MP0009840_abnormal_foam_cell2.87670058
11MP0005257_abnormal_intraocular_pressure2.85423894
12MP0005083_abnormal_biliary_tract2.80852820
13MP0003705_abnormal_hypodermis_morpholog2.71730070
14MP0001666_abnormal_nutrient_absorption2.63106780
15MP0005058_abnormal_lysosome_morphology2.53322288
16MP0002138_abnormal_hepatobiliary_system2.47412961
17MP0003195_calcinosis2.46995740
18MP0005332_abnormal_amino_acid2.45922052
19MP0003191_abnormal_cellular_cholesterol2.29365462
20MP0005623_abnormal_meninges_morphology2.14080002
21MP0002254_reproductive_system_inflammat2.13850421
22MP0004019_abnormal_vitamin_homeostasis2.07526406
23MP0003950_abnormal_plasma_membrane1.96229808
24MP0000609_abnormal_liver_physiology1.92471244
25MP0002118_abnormal_lipid_homeostasis1.81609959
26MP0003279_aneurysm1.72729135
27MP0005409_darkened_coat_color1.71342291
28MP0003091_abnormal_cell_migration1.68175109
29MP0005319_abnormal_enzyme/_coenzyme1.65580146
30MP0003941_abnormal_skin_development1.63786968
31MP0004858_abnormal_nervous_system1.56784085
32MP0005451_abnormal_body_composition1.52100736
33MP0000003_abnormal_adipose_tissue1.49127949
34MP0000762_abnormal_tongue_morphology1.48247156
35MP0009643_abnormal_urine_homeostasis1.47657888
36MP0004233_abnormal_muscle_weight1.46907253
37MP0009780_abnormal_chondrocyte_physiolo1.41033516
38MP0002796_impaired_skin_barrier1.39306902
39MP0000678_abnormal_parathyroid_gland1.38305639
40MP0010234_abnormal_vibrissa_follicle1.36094544
41MP0005670_abnormal_white_adipose1.33280333
42MP0003868_abnormal_feces_composition1.31248141
43MP0000733_abnormal_muscle_development1.31175952
44MP0002089_abnormal_postnatal_growth/wei1.28882213
45MP0000767_abnormal_smooth_muscle1.26324850
46MP0010368_abnormal_lymphatic_system1.23717177
47MP0000566_synostosis1.22992554
48MP0000751_myopathy1.22839602
49MP0001958_emphysema1.22329756
50MP0000858_altered_metastatic_potential1.20412717
51MP0004510_myositis1.20203048
52MP0008260_abnormal_autophagy1.19734539
53MP0009053_abnormal_anal_canal1.18356104
54MP0001915_intracranial_hemorrhage1.17880214
55MP0000534_abnormal_ureter_morphology1.10797503
56MP0005584_abnormal_enzyme/coenzyme_acti1.10383173
57MP0000598_abnormal_liver_morphology1.07469289
58MP0010771_integument_phenotype1.05018715
59MP0005508_abnormal_skeleton_morphology1.03340020
60MP0005666_abnormal_adipose_tissue1.01999987
61MP0003329_amyloid_beta_deposits1.01119829
62MP0003453_abnormal_keratinocyte_physiol0.98270964
63MP0005197_abnormal_uvea_morphology0.97950596
64MP0003942_abnormal_urinary_system0.97826944
65MP0002837_dystrophic_cardiac_calcinosis0.94116402
66MP0001756_abnormal_urination0.93296945
67MP0004185_abnormal_adipocyte_glucose0.93037279
68MP0000462_abnormal_digestive_system0.91730096
69MP0004264_abnormal_extraembryonic_tissu0.91410168
70MP0003566_abnormal_cell_adhesion0.91180678
71MP0005220_abnormal_exocrine_pancreas0.90177854
72MP0008961_abnormal_basal_metabolism0.89572079
73MP0003011_delayed_dark_adaptation0.89471108
74MP0000013_abnormal_adipose_tissue0.89246255
75MP0003656_abnormal_erythrocyte_physiolo0.89212168
76MP0004130_abnormal_muscle_cell0.87166337
77MP0002971_abnormal_brown_adipose0.84747101
78MP0005636_abnormal_mineral_homeostasis0.84179103
79MP0001243_abnormal_dermal_layer0.81993702
80MP0002060_abnormal_skin_morphology0.81768106
81MP0010678_abnormal_skin_adnexa0.81335045
82MP0003186_abnormal_redox_activity0.81253845
83MP0009672_abnormal_birth_weight0.80887320
84MP0002078_abnormal_glucose_homeostasis0.80069269
85MP0000579_abnormal_nail_morphology0.79974982
86MP0004043_abnormal_pH_regulation0.77987163
87MP0003172_abnormal_lysosome_physiology0.77914392
88MP0005501_abnormal_skin_physiology0.77789532
89MP0005330_cardiomyopathy0.77717657
90MP0003385_abnormal_body_wall0.77334670
91MP0005248_abnormal_Harderian_gland0.76314954
92MP0001764_abnormal_homeostasis0.76251718
93MP0005193_abnormal_anterior_eye0.75464669
94MP0001348_abnormal_lacrimal_gland0.74039761
95MP0000627_abnormal_mammary_gland0.73792710
96MP0002877_abnormal_melanocyte_morpholog0.71812520
97MP0005647_abnormal_sex_gland0.71014162
98MP0005023_abnormal_wound_healing0.70564578
99MP0000377_abnormal_hair_follicle0.70561553
100MP0002295_abnormal_pulmonary_circulatio0.70494199
101MP0001730_embryonic_growth_arrest0.70419868
102MP0009642_abnormal_blood_homeostasis0.70104362
103MP0009931_abnormal_skin_appearance0.70073404
104MP0004782_abnormal_surfactant_physiolog0.69470563
105MP0001542_abnormal_bone_strength0.69346677
106MP0001661_extended_life_span0.69175072
107MP0005375_adipose_tissue_phenotype0.68045177
108MP0005165_increased_susceptibility_to0.68001504
109MP0000747_muscle_weakness0.67502268
110MP0001614_abnormal_blood_vessel0.67201242
111MP0000750_abnormal_muscle_regeneration0.66902319
112MP0005595_abnormal_vascular_smooth0.66070886
113MP0006036_abnormal_mitochondrial_physio0.65601558
114MP0000759_abnormal_skeletal_muscle0.65569063
115MP0002136_abnormal_kidney_physiology0.65339871
116MP0004947_skin_inflammation0.64851989
117MP0005621_abnormal_cell_physiology0.64515224
118MP0005275_abnormal_skin_tensile0.64501446
119MP0005408_hypopigmentation0.64436594
120MP0000538_abnormal_urinary_bladder0.64212328
121MP0000537_abnormal_urethra_morphology0.63650883
122MP0005503_abnormal_tendon_morphology0.62820422
123MP0002086_abnormal_extraembryonic_tissu0.62738908
124MP0002098_abnormal_vibrissa_morphology0.61514579
125MP0010352_gastrointestinal_tract_polyps0.60501595
126MP0009763_increased_sensitivity_to0.60437613
127MP0002269_muscular_atrophy0.60033560
128MP0004087_abnormal_muscle_fiber0.57342516
129MP0010630_abnormal_cardiac_muscle0.57254133
130MP0006138_congestive_heart_failure0.57231695
131MP0003300_gastrointestinal_ulcer0.56357796
132MP0005084_abnormal_gallbladder_morpholo0.55791804
133MP0002822_catalepsy0.55467021
134MP0001849_ear_inflammation0.54404667
135MP0005334_abnormal_fat_pad0.53299539
136MP0010030_abnormal_orbit_morphology0.53001292
137MP0004272_abnormal_basement_membrane0.52931194
138MP0000467_abnormal_esophagus_morphology0.51914192
139MP0005076_abnormal_cell_differentiation0.51684442
140MP0005395_other_phenotype0.50934769
141MP0009764_decreased_sensitivity_to0.50637832
142MP0009384_cardiac_valve_regurgitation0.49973393
143MP0003283_abnormal_digestive_organ0.49204653
144MP0003115_abnormal_respiratory_system0.49201017
145MP0005266_abnormal_metabolism0.49122245
146MP0005376_homeostasis/metabolism_phenot0.48220784
147MP0005448_abnormal_energy_balance0.47811577
148MP0001765_abnormal_ion_homeostasis0.47710528
149MP0002896_abnormal_bone_mineralization0.47481815
150MP0002234_abnormal_pharynx_morphology0.47032064
151MP0001944_abnormal_pancreas_morphology0.45686121
152MP0008469_abnormal_protein_level0.44717283
153MP0003119_abnormal_digestive_system0.43839230
154MP0002249_abnormal_larynx_morphology0.43675777
155MP0001216_abnormal_epidermal_layer0.43085740
156MP0000604_amyloidosis0.42344360

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.30015125
2Intrahepatic cholestasis (HP:0001406)6.14860921
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.99561698
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.74373641
5Xanthomatosis (HP:0000991)5.45437275
6Hypobetalipoproteinemia (HP:0003563)5.03002591
7Premature rupture of membranes (HP:0001788)4.91989407
8Prolonged partial thromboplastin time (HP:0003645)4.71566245
9Protrusio acetabuli (HP:0003179)4.42701493
10Hyperlipoproteinemia (HP:0010980)4.40717853
11Complement deficiency (HP:0004431)4.37707932
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09978726
13Hyperammonemia (HP:0001987)4.05525325
14Hypoglycemic coma (HP:0001325)4.03654288
15Ketosis (HP:0001946)3.99731291
16Hypolipoproteinemia (HP:0010981)3.97168049
17Hyperglycinuria (HP:0003108)3.77936050
18Epidermoid cyst (HP:0200040)3.71683706
19Abnormality of the common coagulation pathway (HP:0010990)3.70646597
20Joint hemorrhage (HP:0005261)3.70235489
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.67341139
22Hypoalphalipoproteinemia (HP:0003233)3.65323048
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.61456124
24Hyperglycinemia (HP:0002154)3.51779859
25Gout (HP:0001997)3.50098183
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.46637127
27Abnormality of serine family amino acid metabolism (HP:0010894)3.42467489
28Abnormality of glycine metabolism (HP:0010895)3.42467489
29Ketoacidosis (HP:0001993)3.41506801
30Fat malabsorption (HP:0002630)3.40063387
31Abnormality of the intrinsic pathway (HP:0010989)3.39022904
32Vertebral compression fractures (HP:0002953)3.34472633
33Abnormality of complement system (HP:0005339)3.31533256
34Abnormality of fatty-acid metabolism (HP:0004359)3.20809128
35Abnormality of methionine metabolism (HP:0010901)3.09090024
36Fragile skin (HP:0001030)3.05615764
37Atrophic scars (HP:0001075)3.04622792
38Right ventricular cardiomyopathy (HP:0011663)3.02464709
39Hepatocellular carcinoma (HP:0001402)2.95539858
40Achilles tendon contracture (HP:0001771)2.94041566
41Abnormality of purine metabolism (HP:0004352)2.93569425
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.87927628
43Abnormality of nucleobase metabolism (HP:0010932)2.85919974
44Short nail (HP:0001799)2.85189286
45Hyperacusis (HP:0010780)2.83131408
46Arterial tortuosity (HP:0005116)2.82219320
47Hypercholesterolemia (HP:0003124)2.80812363
48Myocardial infarction (HP:0001658)2.80503643
49Cervical subluxation (HP:0003308)2.78795684
50Ulnar bowing (HP:0003031)2.78316879
51Distal upper limb amyotrophy (HP:0007149)2.77966629
52Upper limb amyotrophy (HP:0009129)2.77966629
53Distal lower limb amyotrophy (HP:0008944)2.74306779
54Abnormality of pyrimidine metabolism (HP:0004353)2.70621072
55Cerebral aneurysm (HP:0004944)2.68492940
56Vascular tortuosity (HP:0004948)2.66376545
57Vascular calcification (HP:0004934)2.64599637
58Skin nodule (HP:0200036)2.62800590
59Hyperbilirubinemia (HP:0002904)2.62273600
60Distal lower limb muscle weakness (HP:0009053)2.62014250
61Late onset (HP:0003584)2.60915687
62Abnormality of the distal phalanges of the toes (HP:0010182)2.57878180
63Conjugated hyperbilirubinemia (HP:0002908)2.57047386
64Aortic dissection (HP:0002647)2.56907742
65Spinal rigidity (HP:0003306)2.56533181
66Ankle contracture (HP:0006466)2.54012958
67Esophageal varix (HP:0002040)2.53850079
68Natal tooth (HP:0000695)2.50955972
69Hypoglycemic seizures (HP:0002173)2.50917623
70Hypochromic microcytic anemia (HP:0004840)2.49473787
71Axonal loss (HP:0003447)2.48787560
72Delayed CNS myelination (HP:0002188)2.47815307
73Cardiovascular calcification (HP:0011915)2.44073295
74Malnutrition (HP:0004395)2.42553250
75Generalized aminoaciduria (HP:0002909)2.42346979
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39158315
77Dicarboxylic aciduria (HP:0003215)2.39158315
78Elbow flexion contracture (HP:0002987)2.38851577
79Flat acetabular roof (HP:0003180)2.38437926
80Hyperinsulinemic hypoglycemia (HP:0000825)2.37732078
81Steatorrhea (HP:0002570)2.37350119
82Shallow orbits (HP:0000586)2.35106558
83Neonatal onset (HP:0003623)2.34334283
84Bladder diverticulum (HP:0000015)2.33979136
85Metabolic acidosis (HP:0001942)2.33774371
86Broad face (HP:0000283)2.33614563
87Spontaneous abortion (HP:0005268)2.32266693
88Increased connective tissue (HP:0009025)2.32050049
89Spastic diplegia (HP:0001264)2.30951333
90Abnormal cartilage morphology (HP:0002763)2.28797758
91Abnormality of glycolipid metabolism (HP:0010969)2.28131137
92Abnormality of liposaccharide metabolism (HP:0010968)2.28131137
93Abnormality of glycosphingolipid metabolism (HP:0004343)2.28131137
94Hyperuricemia (HP:0002149)2.27577337
95Increased purine levels (HP:0004368)2.27577337
96Mildly elevated creatine phosphokinase (HP:0008180)2.26739847
97Polycythemia (HP:0001901)2.26540807
98Abnormality of serum amino acid levels (HP:0003112)2.25948251
99Advanced eruption of teeth (HP:0006288)2.22860823
100Cholelithiasis (HP:0001081)2.21525932
101Hydroxyprolinuria (HP:0003080)2.21403924
102Abnormality of proline metabolism (HP:0010907)2.21403924
103Abnormal gallbladder morphology (HP:0012437)2.18185263
104Osteolytic defects of the hand bones (HP:0009699)2.17987764
105Osteolytic defects of the phalanges of the hand (HP:0009771)2.17987764
106Hyperglycemia (HP:0003074)2.17665345
107Abnormality of carpal bone ossification (HP:0006257)2.12766725
108Blue sclerae (HP:0000592)2.12449256
109Wormian bones (HP:0002645)2.12389318
110Lethargy (HP:0001254)2.12382675
111Thin bony cortex (HP:0002753)2.12074164
112Sensorimotor neuropathy (HP:0007141)2.09361146
113Nuclear cataract (HP:0100018)2.07157040
114Aortic aneurysm (HP:0004942)2.06785385
115Disproportionate tall stature (HP:0001519)2.06401742
116Irritability (HP:0000737)2.05103550
117Turricephaly (HP:0000262)2.01479669
118Myoglobinuria (HP:0002913)2.01000168
119Rickets (HP:0002748)2.00178616
120Hand muscle atrophy (HP:0009130)1.99589757
121Abnormality of the acetabulum (HP:0003170)1.98654004
122Systemic lupus erythematosus (HP:0002725)1.98328431
123Trismus (HP:0000211)1.98191826
124Hemorrhage of the eye (HP:0011885)1.97992143
125Abnormal ossification of hand bones (HP:0005921)1.97634639
126Neonatal death (HP:0003811)1.96578264
127Glomerulosclerosis (HP:0000096)1.96338455
128Abnormality of dentin (HP:0010299)1.95268137
129Mitral regurgitation (HP:0001653)1.94728485
130Focal segmental glomerulosclerosis (HP:0000097)1.91531844
131Hyperparathyroidism (HP:0000843)1.91403217
132Abnormality of nail color (HP:0100643)1.91176162
133Proximal tubulopathy (HP:0000114)1.91173489
134Abnormality of the Achilles tendon (HP:0005109)1.90154958
135Alkalosis (HP:0001948)1.89057777
136Generalized amyotrophy (HP:0003700)1.88256596
137Difficulty climbing stairs (HP:0003551)1.87034455
138Urinary glycosaminoglycan excretion (HP:0003541)1.86140801
139Mucopolysacchariduria (HP:0008155)1.86140801
140Back pain (HP:0003418)1.85230219
141Abnormal enzyme/coenzyme activity (HP:0012379)1.84755403
142Mitral valve prolapse (HP:0001634)1.83756714
143Cerebral inclusion bodies (HP:0100314)1.83353171
144Abnormal gallbladder physiology (HP:0012438)1.83264296
145Cholecystitis (HP:0001082)1.83264296
146Aneurysm (HP:0002617)1.83193109
147Abnormality of the gallbladder (HP:0005264)1.82946902
148Neonatal short-limb short stature (HP:0008921)1.82666686
149Acanthosis nigricans (HP:0000956)1.81548097
150Symptomatic seizures (HP:0011145)1.81403406
151Neurofibrillary tangles (HP:0002185)1.80670683
152Vomiting (HP:0002013)1.80657359
153Long toe (HP:0010511)1.80254846
154Alopecia of scalp (HP:0002293)1.79497434
155Asymmetry of the thorax (HP:0001555)1.79459875
156Genu recurvatum (HP:0002816)1.79119954
157Acanthocytosis (HP:0001927)1.78782064
158Bowed forearm bones (HP:0003956)1.78314365
159Bowing of the arm (HP:0006488)1.78314365
160Abnormality of polysaccharide metabolism (HP:0011012)1.77992019
161Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77992019
162Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77992019
163Renal duplication (HP:0000075)1.77517664
164Lower limb amyotrophy (HP:0007210)1.76853405
165Selective tooth agenesis (HP:0001592)1.76080536
166Pancreatitis (HP:0001733)1.74917873
167Insomnia (HP:0100785)1.74733899
168Enlarged kidneys (HP:0000105)1.74502090
169Spondylolisthesis (HP:0003302)1.74455708
170Dysostosis multiplex (HP:0000943)1.74242735
171Stridor (HP:0010307)1.74126062
172Lymphangioma (HP:0100764)1.73779733
173Spinal cord compression (HP:0002176)1.72202048
174Soft skin (HP:0000977)1.69477259
175Reticulocytosis (HP:0001923)1.68692968
176Nephrolithiasis (HP:0000787)1.68515601
177Coxa vara (HP:0002812)1.67928372
178Mitral stenosis (HP:0001718)1.67826196
179Abnormality of the pancreatic islet cells (HP:0006476)1.67780755
180Abnormality of endocrine pancreas physiology (HP:0012093)1.67780755
181Abnormality of the umbilical cord (HP:0010881)1.66124571
182Ileus (HP:0002595)1.65697876
183Pterygium (HP:0001059)1.65310284
184Long palpebral fissure (HP:0000637)1.64099975
185Congenital glaucoma (HP:0001087)1.63760054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.98884578
2IRAK33.87881082
3TRIB33.83542767
4ERN13.62754484
5PKN23.16644208
6LATS12.85149764
7EPHA22.77086215
8SIK12.63055636
9NME22.55353218
10FGFR42.54751457
11MAP3K32.18462389
12PTK62.13785272
13ERBB42.04009407
14SMG12.01459661
15TESK11.94917734
16MAP3K101.91296862
17EEF2K1.81788048
18MST1R1.72393261
19LMTK21.70168048
20MAP3K21.66568428
21RIPK11.65302360
22MAP2K21.63874805
23STK38L1.58970766
24TAOK11.47957332
25TBK11.45531296
26NTRK11.43553214
27EPHB21.42905859
28PTK21.41469264
29INSRR1.38425889
30ARAF1.37249223
31MAPK151.36648443
32LATS21.35913595
33TAOK31.33397243
34MAP3K91.32065157
35TTN1.28206754
36MAPK111.26915302
37MAPKAPK31.26572779
38PIM21.20670876
39ICK1.20291223
40PDGFRA1.18114621
41LIMK11.14393182
42MAP3K71.13155715
43BMX1.12357027
44CDC42BPA1.12330212
45PRPF4B1.11513628
46DYRK1B1.10930115
47FLT31.03665913
48MAP2K31.03033023
49MTOR1.02354054
50MET1.01337656
51EPHB11.01292585
52MAP3K110.97661585
53NEK90.96312940
54CDK120.94620117
55TGFBR20.91398514
56PAK40.90613846
57CDK60.89503466
58WNK40.89377460
59PRKAA20.89110783
60CDK80.88387362
61MAP2K10.83127275
62DAPK20.80365603
63WNK30.77353277
64GSK3A0.76974442
65MOS0.73774061
66PAK30.72563195
67LRRK20.72306957
68RPS6KA20.71892096
69STK380.71522571
70KSR20.71120675
71PRKD30.70951468
72BRAF0.69211930
73MAP3K120.68810014
74STK30.68669014
75FER0.66790721
76MAP2K40.66477990
77ABL20.66336183
78SCYL20.66181508
79MAP3K60.66172146
80PRKD10.65595711
81ERBB20.65395604
82PRKG20.65147988
83PRKAA10.64140558
84PDPK10.63756350
85RPS6KB20.63474277
86DAPK30.62589753
87SGK30.61302964
88PDGFRB0.60292905
89RPS6KA10.59669792
90IRAK20.58272217
91RPS6KA40.56752844
92CHUK0.56150972
93MAP3K10.55819849
94JAK20.55747769
95CDK90.54469590
96IKBKE0.53844025
97PIK3CG0.53680465
98RET0.52462458
99TIE10.52433550
100GRK60.52025179
101TRPM70.51160829
102PRKCZ0.51114237
103MAP3K80.50680793
104FRK0.49768802
105ILK0.48307649
106NEK10.47325535
107FGFR30.46809578
108MARK20.46216413
109DDR20.46033113
110CAMK2G0.45605882
111CAMK1D0.44859342
112FGFR10.44053599
113ROCK20.43715646
114CDK40.43561834
115DMPK0.43463976
116MELK0.43088182
117PAK20.41134777
118RPS6KC10.41052866
119RPS6KL10.41052866
120AKT20.40756753
121MYLK0.40040850
122CDK70.40003372
123STK240.39961135
124FGFR20.39844238
125TESK20.39565884
126PRKCI0.39407991
127AURKA0.39002793
128RPS6KA60.38955477
129STK100.38904226
130ROCK10.38787476
131MAP3K50.37126699
132MAPK70.35490626
133TAOK20.34774355
134PRKACG0.34705834
135PRKD20.34658504
136TYK20.34323271
137MAP3K130.33199522
138PBK0.32043488
139PAK10.30792627
140MUSK0.29939256
141CAMK1G0.29060451
142MAPKAPK20.27835568
143CAMK2D0.26294722

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.99869405
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.56633573
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31967271
4Nitrogen metabolism_Homo sapiens_hsa009103.26767187
5Arginine biosynthesis_Homo sapiens_hsa002202.98336617
6Tryptophan metabolism_Homo sapiens_hsa003802.71516333
7Fatty acid degradation_Homo sapiens_hsa000712.70122084
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66818315
9Other glycan degradation_Homo sapiens_hsa005112.62938601
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44274093
11Complement and coagulation cascades_Homo sapiens_hsa046102.40947690
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.35727644
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.35577244
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32918713
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.16140368
16Butanoate metabolism_Homo sapiens_hsa006502.03285584
17PPAR signaling pathway_Homo sapiens_hsa033202.01366673
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00931436
19Propanoate metabolism_Homo sapiens_hsa006401.97565529
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95858439
21Peroxisome_Homo sapiens_hsa041461.86316584
22Fatty acid metabolism_Homo sapiens_hsa012121.85896543
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84955708
24Selenocompound metabolism_Homo sapiens_hsa004501.78060535
25Histidine metabolism_Homo sapiens_hsa003401.77129795
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67331230
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.66451401
28beta-Alanine metabolism_Homo sapiens_hsa004101.65117665
29Chemical carcinogenesis_Homo sapiens_hsa052041.62955692
30Bile secretion_Homo sapiens_hsa049761.62904809
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62103405
32Phenylalanine metabolism_Homo sapiens_hsa003601.58357204
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.57094402
34Chronic myeloid leukemia_Homo sapiens_hsa052201.56080246
35Lysosome_Homo sapiens_hsa041421.55379935
36Proteoglycans in cancer_Homo sapiens_hsa052051.55119694
37Sulfur metabolism_Homo sapiens_hsa009201.49887058
38Fat digestion and absorption_Homo sapiens_hsa049751.49838271
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.48944769
40Caffeine metabolism_Homo sapiens_hsa002321.46907897
41Vibrio cholerae infection_Homo sapiens_hsa051101.46622263
42Pyruvate metabolism_Homo sapiens_hsa006201.44687987
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.44009947
44Retinol metabolism_Homo sapiens_hsa008301.38141126
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35058622
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33962216
47Carbon metabolism_Homo sapiens_hsa012001.31510196
48Starch and sucrose metabolism_Homo sapiens_hsa005001.31158287
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30076261
50Biosynthesis of amino acids_Homo sapiens_hsa012301.29732226
51Tyrosine metabolism_Homo sapiens_hsa003501.26086042
52Renal cell carcinoma_Homo sapiens_hsa052111.25831314
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.25086891
54Staphylococcus aureus infection_Homo sapiens_hsa051501.25006458
55Pancreatic cancer_Homo sapiens_hsa052121.22242906
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21003586
57Sphingolipid metabolism_Homo sapiens_hsa006001.20443790
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19688791
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18292938
60Thyroid cancer_Homo sapiens_hsa052161.16137688
61Folate biosynthesis_Homo sapiens_hsa007901.11945539
62ABC transporters_Homo sapiens_hsa020101.11801706
63Notch signaling pathway_Homo sapiens_hsa043301.10975396
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09245634
65Lysine degradation_Homo sapiens_hsa003101.09036569
66Cyanoamino acid metabolism_Homo sapiens_hsa004601.02414002
67VEGF signaling pathway_Homo sapiens_hsa043701.00869758
68Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00778695
69Dilated cardiomyopathy_Homo sapiens_hsa054141.00605437
70Arginine and proline metabolism_Homo sapiens_hsa003300.99028742
71N-Glycan biosynthesis_Homo sapiens_hsa005100.96607819
72MicroRNAs in cancer_Homo sapiens_hsa052060.95495059
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95338569
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94562293
75Sulfur relay system_Homo sapiens_hsa041220.90621121
76Fatty acid elongation_Homo sapiens_hsa000620.89444494
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89285414
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88851621
79ErbB signaling pathway_Homo sapiens_hsa040120.86239031
80Steroid biosynthesis_Homo sapiens_hsa001000.86051931
81Vitamin digestion and absorption_Homo sapiens_hsa049770.85394192
82Glioma_Homo sapiens_hsa052140.85326487
83Salmonella infection_Homo sapiens_hsa051320.84657635
84Endometrial cancer_Homo sapiens_hsa052130.77909343
85Shigellosis_Homo sapiens_hsa051310.77749289
86Acute myeloid leukemia_Homo sapiens_hsa052210.76980939
87Non-small cell lung cancer_Homo sapiens_hsa052230.75504953
88Glycerolipid metabolism_Homo sapiens_hsa005610.74888916
89Melanoma_Homo sapiens_hsa052180.74063875
90Endocytosis_Homo sapiens_hsa041440.73533085
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.73417967
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72635250
93Glutathione metabolism_Homo sapiens_hsa004800.70523209
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.69332512
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68045316
96Axon guidance_Homo sapiens_hsa043600.66700114
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66111530
98TGF-beta signaling pathway_Homo sapiens_hsa043500.64078443
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63870545
100Pathways in cancer_Homo sapiens_hsa052000.62989135
101TNF signaling pathway_Homo sapiens_hsa046680.59831728
102Prostate cancer_Homo sapiens_hsa052150.59486140
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58529280
104Vitamin B6 metabolism_Homo sapiens_hsa007500.58464345
105Insulin resistance_Homo sapiens_hsa049310.57842031
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55296910
107HIF-1 signaling pathway_Homo sapiens_hsa040660.54458538
108Basal cell carcinoma_Homo sapiens_hsa052170.53826149
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.53260424
110One carbon pool by folate_Homo sapiens_hsa006700.53023533
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53013508
112Apoptosis_Homo sapiens_hsa042100.49110142
113GnRH signaling pathway_Homo sapiens_hsa049120.48680896
114Fatty acid biosynthesis_Homo sapiens_hsa000610.48437081
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45250531
116Estrogen signaling pathway_Homo sapiens_hsa049150.44438953
117Prion diseases_Homo sapiens_hsa050200.43950491
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.43377141
119Pertussis_Homo sapiens_hsa051330.43124479
120Pentose phosphate pathway_Homo sapiens_hsa000300.40482609
121Bladder cancer_Homo sapiens_hsa052190.40206077
122Galactose metabolism_Homo sapiens_hsa000520.38603489
123Fructose and mannose metabolism_Homo sapiens_hsa000510.38567049
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33462971
125Metabolic pathways_Homo sapiens_hsa011000.31829742
126AMPK signaling pathway_Homo sapiens_hsa041520.29369328
127Glucagon signaling pathway_Homo sapiens_hsa049220.29087489
128Linoleic acid metabolism_Homo sapiens_hsa005910.23466212
129Adherens junction_Homo sapiens_hsa045200.17340533
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.16688057
131Insulin signaling pathway_Homo sapiens_hsa049100.15907437
132Amoebiasis_Homo sapiens_hsa051460.14877812
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.14271310
134Protein digestion and absorption_Homo sapiens_hsa049740.13938110
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12532521
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09510536
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08612326
138Small cell lung cancer_Homo sapiens_hsa052220.07515987
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07089836
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.04728425
141ECM-receptor interaction_Homo sapiens_hsa045120.04626650
142Tight junction_Homo sapiens_hsa045300.04113070
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.03062211
144Ovarian steroidogenesis_Homo sapiens_hsa049130.02715428
145Mineral absorption_Homo sapiens_hsa049780.02096289
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00719892
147Focal adhesion_Homo sapiens_hsa045100.00115388
148Hepatitis C_Homo sapiens_hsa051600.00076340
149mTOR signaling pathway_Homo sapiens_hsa04150-0.0414370
150Hippo signaling pathway_Homo sapiens_hsa04390-0.0180951

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