SHC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.64131810
2COPI coating of Golgi vesicle (GO:0048205)6.01808095
3Golgi transport vesicle coating (GO:0048200)6.01808095
4cell-substrate junction assembly (GO:0007044)4.98071287
5desmosome organization (GO:0002934)4.12907182
6planar cell polarity pathway involved in neural tube closure (GO:0090179)3.97201737
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.96924763
8cell-substrate adherens junction assembly (GO:0007045)3.93166816
9focal adhesion assembly (GO:0048041)3.93166816
10adherens junction assembly (GO:0034333)3.88887679
11endothelial cell morphogenesis (GO:0001886)3.88404862
12COPII vesicle coating (GO:0048208)3.87499410
13negative regulation of chondrocyte differentiation (GO:0032331)3.79799725
14folic acid-containing compound biosynthetic process (GO:0009396)3.78797231
15mesodermal cell differentiation (GO:0048333)3.76674936
16* activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.70550204
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.66695752
18chondrocyte proliferation (GO:0035988)3.62013432
19protein localization to endosome (GO:0036010)3.61697502
20* positive regulation of nuclease activity (GO:0032075)3.60378690
21protein retention in ER lumen (GO:0006621)3.50154116
22dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.46041135
23* endoplasmic reticulum unfolded protein response (GO:0030968)3.35246260
24positive regulation of blood vessel endothelial cell migration (GO:0043536)3.34599648
25* regulation of nuclease activity (GO:0032069)3.32797652
26substrate-dependent cell migration (GO:0006929)3.24861966
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.23234898
28* cellular response to unfolded protein (GO:0034620)3.21293459
29apoptotic cell clearance (GO:0043277)3.19307263
304-hydroxyproline metabolic process (GO:0019471)3.18964052
31semaphorin-plexin signaling pathway (GO:0071526)3.15373202
32collagen metabolic process (GO:0032963)3.11377420
33barbed-end actin filament capping (GO:0051016)3.08842551
34cell migration involved in heart development (GO:0060973)3.05708645
35bone trabecula formation (GO:0060346)3.05403714
36* ER-nucleus signaling pathway (GO:0006984)3.03972232
37* cellular response to topologically incorrect protein (GO:0035967)3.03330382
38extracellular matrix disassembly (GO:0022617)2.98135013
39hyaluronan catabolic process (GO:0030214)2.97036197
40negative regulation of fatty acid transport (GO:2000192)2.96945500
41exocrine pancreas development (GO:0031017)2.96838345
42stress fiber assembly (GO:0043149)2.96193453
43cell migration involved in sprouting angiogenesis (GO:0002042)2.95774735
44hypotonic response (GO:0006971)2.95495342
45paraxial mesoderm development (GO:0048339)2.94755994
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94544933
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.94544933
48sequestering of metal ion (GO:0051238)2.94078969
49vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.93918783
50multicellular organismal macromolecule metabolic process (GO:0044259)2.91267509
51retina vasculature morphogenesis in camera-type eye (GO:0061299)2.89718590
52muscle cell migration (GO:0014812)2.89494920
53collagen catabolic process (GO:0030574)2.87270273
54type B pancreatic cell proliferation (GO:0044342)2.86306554
55Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.85150625
56kidney mesenchyme development (GO:0072074)2.85113334
57gap junction assembly (GO:0016264)2.82812468
58substrate adhesion-dependent cell spreading (GO:0034446)2.82099599
59regulation of early endosome to late endosome transport (GO:2000641)2.79938730
60low-density lipoprotein particle clearance (GO:0034383)2.79828578
61blood vessel endothelial cell migration (GO:0043534)2.79442997
62atrioventricular valve morphogenesis (GO:0003181)2.78986728
63negative regulation of cartilage development (GO:0061037)2.75746732
64positive regulation of osteoblast proliferation (GO:0033690)2.75001668
65regulation of transforming growth factor beta2 production (GO:0032909)2.74519464
66multicellular organismal metabolic process (GO:0044236)2.74271598
67maternal placenta development (GO:0001893)2.73054409
68heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.72624632
69activation of Rac GTPase activity (GO:0032863)2.71792026
70regulation of establishment of planar polarity (GO:0090175)2.71453552
71cell adhesion mediated by integrin (GO:0033627)2.71057068
72positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.69548563
73cellular response to vitamin D (GO:0071305)2.69362345
74protein maturation by protein folding (GO:0022417)2.69309485
75membrane protein ectodomain proteolysis (GO:0006509)2.65562511
76pinocytosis (GO:0006907)2.65423133
77endothelial cell chemotaxis (GO:0035767)2.63983824
78L-alpha-amino acid transmembrane transport (GO:1902475)2.62218348
79multicellular organismal catabolic process (GO:0044243)2.62118268
80positive regulation of SMAD protein import into nucleus (GO:0060391)2.61850309
81skin morphogenesis (GO:0043589)2.59274870
82regulation of plasminogen activation (GO:0010755)2.58806058
83protein heterotrimerization (GO:0070208)2.58603329
84antigen processing and presentation of endogenous antigen (GO:0019883)2.58311955
85* response to endoplasmic reticulum stress (GO:0034976)2.57759917
86negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57546363
87cytoskeletal anchoring at plasma membrane (GO:0007016)2.57404260
88cochlea morphogenesis (GO:0090103)2.56996940
89positive regulation of histone deacetylation (GO:0031065)2.56381459
90renal filtration (GO:0097205)2.56222574
91endodermal cell differentiation (GO:0035987)2.55873485
92negative regulation of anoikis (GO:2000811)2.55740535
93vesicle coating (GO:0006901)2.55230059
94cell junction assembly (GO:0034329)2.55199423
95peptidyl-proline hydroxylation (GO:0019511)2.55043338
96sequestering of extracellular ligand from receptor (GO:0035581)2.54425828
97hippo signaling (GO:0035329)2.54109160
98cellular response to vitamin (GO:0071295)2.53133650
99collagen fibril organization (GO:0030199)2.52820127
100regulation of SMAD protein import into nucleus (GO:0060390)2.52051864
101extracellular matrix organization (GO:0030198)2.52026979
102extracellular structure organization (GO:0043062)2.50995180
103cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.50734749
104regulation of translational fidelity (GO:0006450)2.48719627
105negative regulation of smooth muscle cell migration (GO:0014912)2.48513230
106basement membrane organization (GO:0071711)2.48237727
107extracellular matrix assembly (GO:0085029)2.47953872
108vascular endothelial growth factor signaling pathway (GO:0038084)2.47581025
109regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.47393748
110regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.45951345
111endocytic recycling (GO:0032456)2.45529006
112convergent extension (GO:0060026)2.43732683
113membrane raft organization (GO:0031579)2.43543263
114tetrahydrofolate metabolic process (GO:0046653)2.43285600
115positive regulation of endothelial cell apoptotic process (GO:2000353)2.41904557
116positive regulation of endothelial cell migration (GO:0010595)2.41056827
117pteridine-containing compound biosynthetic process (GO:0042559)2.39659039
118growth hormone receptor signaling pathway (GO:0060396)2.37696128
119heterochromatin organization (GO:0070828)2.34711806
120protein hydroxylation (GO:0018126)2.31685548
121regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.31200547
122response to laminar fluid shear stress (GO:0034616)2.31053104
123* response to unfolded protein (GO:0006986)2.29958873
124regulation of cholesterol homeostasis (GO:2000188)2.28056582
125proline biosynthetic process (GO:0006561)2.24051368
126* response to topologically incorrect protein (GO:0035966)2.19656937
127positive regulation of p38MAPK cascade (GO:1900745)2.19522222
128JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.18315434
129regulation of cholesterol storage (GO:0010885)2.18217200
130T cell apoptotic process (GO:0070231)2.18151564
131protein carboxylation (GO:0018214)2.17528848
132peptidyl-glutamic acid carboxylation (GO:0017187)2.17528848
133ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.17265955
134valine metabolic process (GO:0006573)2.16814567
135wound healing, spreading of epidermal cells (GO:0035313)2.16777215
136polarized epithelial cell differentiation (GO:0030859)2.14348581
137antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.14343923
138tricarboxylic acid metabolic process (GO:0072350)2.14332947
139protein autoprocessing (GO:0016540)2.11915359
140embryonic process involved in female pregnancy (GO:0060136)2.11798789
141positive regulation of fatty acid beta-oxidation (GO:0032000)2.10243974
142antigen processing and presentation via MHC class Ib (GO:0002475)2.09541921
143cellular response to nutrient (GO:0031670)2.08904318
144morphogenesis of an endothelium (GO:0003159)2.08500054
145endothelial tube morphogenesis (GO:0061154)2.08500054
146apoptotic process involved in morphogenesis (GO:0060561)2.07108234
147cellular response to growth hormone stimulus (GO:0071378)2.06725708
148positive regulation of transcription regulatory region DNA binding (GO:2000679)2.06322368
149positive regulation of protein deacetylation (GO:0090312)2.06051883
150UDP-N-acetylglucosamine metabolic process (GO:0006047)2.03262479
151keratan sulfate catabolic process (GO:0042340)2.02315074
152regulation of glucose import in response to insulin stimulus (GO:2001273)2.00986010
153signal peptide processing (GO:0006465)2.00902735
154regulation of fatty acid beta-oxidation (GO:0031998)2.00589258
155positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.00336054
156establishment of apical/basal cell polarity (GO:0035089)2.00174450
157glandular epithelial cell development (GO:0002068)1.99589833
158peptidyl-asparagine modification (GO:0018196)1.98877740
159organ regeneration (GO:0031100)1.98289424
160protein N-linked glycosylation via asparagine (GO:0018279)1.98073818
161positive regulation of natural killer cell differentiation (GO:0032825)1.97679650
162regulation of integrin activation (GO:0033623)1.96580051
163negative regulation of glycoprotein biosynthetic process (GO:0010561)1.96270724
164pentose-phosphate shunt (GO:0006098)1.96238049
165peptide catabolic process (GO:0043171)1.93188596
166glucocorticoid receptor signaling pathway (GO:0042921)1.92742176
167positive regulation of hormone biosynthetic process (GO:0046886)1.92174074
168wound healing, spreading of cells (GO:0044319)1.91958350
169negative regulation of bone resorption (GO:0045779)1.91475660
170negative regulation of fibrinolysis (GO:0051918)1.91028763
171epithelial cell-cell adhesion (GO:0090136)1.91008076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.34282555
2* EGR1_19374776_ChIP-ChIP_THP-1_Human3.06797401
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96972556
4E2F7_22180533_ChIP-Seq_HELA_Human2.93917991
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.84228287
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63705416
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.51921752
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45357180
9ZNF263_19887448_ChIP-Seq_K562_Human2.32297848
10CLOCK_20551151_ChIP-Seq_293T_Human2.27894191
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.23162928
12* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20297696
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.20180454
14MYC_22102868_ChIP-Seq_BL_Human2.19995862
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11582784
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11439074
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.04602357
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04263027
19* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03844418
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.00470654
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99641601
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97838103
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86519327
24UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.79278052
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77245428
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.74821586
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.73885475
28VDR_21846776_ChIP-Seq_THP-1_Human1.72637966
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65420627
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63196537
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63090973
32TFEB_21752829_ChIP-Seq_HELA_Human1.61861829
33TP53_22127205_ChIP-Seq_IMR90_Human1.61381106
34* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61329235
35* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61149415
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57254934
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52756350
38GATA1_22025678_ChIP-Seq_K562_Human1.52582738
39* LXR_22158963_ChIP-Seq_LIVER_Mouse1.52469718
40* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51286666
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51048677
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50945861
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48585901
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46036564
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45112513
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.44138353
47* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42773856
48* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42695259
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42004335
50* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39715127
51ATF3_27146783_Chip-Seq_COLON_Human1.39612413
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38600378
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.37855582
54* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35620153
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.35541601
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32222917
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.31183904
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31121777
59MAF_26560356_Chip-Seq_TH1_Human1.30958508
60KDM2B_26808549_Chip-Seq_K562_Human1.30127646
61TCF7_22412390_ChIP-Seq_EML_Mouse1.28749514
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25833794
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24024253
64RACK7_27058665_Chip-Seq_MCF-7_Human1.22587076
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22488060
66* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21866112
67* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20980583
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20522375
69* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20317552
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.20067145
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19985876
72UTX_26944678_Chip-Seq_JUKART_Human1.18274176
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17558528
74NCOR1_26117541_ChIP-Seq_K562_Human1.16863461
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16840667
76* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16152394
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.16064028
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15062752
79VDR_24763502_ChIP-Seq_THP-1_Human1.14295942
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13900273
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13672394
82JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13295259
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13269813
84FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11950016
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11269106
86* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10643377
87* TET1_21451524_ChIP-Seq_MESCs_Mouse1.10204571
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.10038135
89MYB_26560356_Chip-Seq_TH2_Human1.09458120
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09361621
91* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09054516
92IRF8_21731497_ChIP-ChIP_J774_Mouse1.08970489
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08722402
94* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08574832
95TBX20_22328084_ChIP-Seq_HEART_Mouse1.08492144
96TBX20_22080862_ChIP-Seq_HEART_Mouse1.08492144
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07450776
98* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06899094
99MYB_26560356_Chip-Seq_TH1_Human1.06502111
100GATA6_25053715_ChIP-Seq_YYC3_Human1.05626810
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04391586
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04015279
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03686436
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03341870
105AR_21909140_ChIP-Seq_LNCAP_Human1.03330993
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02644290
107SPI1_23547873_ChIP-Seq_NB4_Human1.02616582
108CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02560583
109KDM2B_26808549_Chip-Seq_DND41_Human1.02139543
110NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02108432
111* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01667650
112RUNX1_22412390_ChIP-Seq_EML_Mouse1.01474375
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01279171
114* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01179715
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00753240
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00753240
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00215658
118ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00057588
119KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00040815
120GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99958888
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99914688
122CJUN_26792858_Chip-Seq_BT549_Human0.99245342
123ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99207245
124SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99036839
125* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98958450
126MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98882029
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98018602
128E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97874254
129TP53_23651856_ChIP-Seq_MEFs_Mouse0.97713305
130* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97672742
131* LXR_22292898_ChIP-Seq_THP-1_Human0.97054815
132NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97019877
133IRF8_27001747_Chip-Seq_BMDM_Mouse0.96781780
134* UBF1/2_26484160_Chip-Seq_HMECs_Human0.96448396
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.96276252
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95594896
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95577632
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94930621
139FOXO3_23340844_ChIP-Seq_DLD1_Human0.94837261
140EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94560897
141SA1_27219007_Chip-Seq_ERYTHROID_Human0.93982869
142IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93835442
143* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93598612
144BRD4_25478319_ChIP-Seq_HGPS_Human0.93510409
145ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92198168
146TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91997009
147CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91967771
148JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91198278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.92873086
2MP0003705_abnormal_hypodermis_morpholog3.24178536
3MP0002877_abnormal_melanocyte_morpholog2.71679479
4MP0006054_spinal_hemorrhage2.59755459
5MP0003941_abnormal_skin_development2.51658430
6MP0010352_gastrointestinal_tract_polyps2.39999859
7MP0005275_abnormal_skin_tensile2.34062992
8* MP0003566_abnormal_cell_adhesion1.96801505
9MP0003300_gastrointestinal_ulcer1.93340699
10MP0003950_abnormal_plasma_membrane1.91510210
11MP0003279_aneurysm1.88381316
12MP0004858_abnormal_nervous_system1.86773097
13MP0005503_abnormal_tendon_morphology1.85536018
14MP0005076_abnormal_cell_differentiation1.78963470
15MP0000762_abnormal_tongue_morphology1.78069875
16MP0005023_abnormal_wound_healing1.71832845
17MP0000579_abnormal_nail_morphology1.69690359
18MP0004272_abnormal_basement_membrane1.55790013
19MP0002796_impaired_skin_barrier1.53965214
20MP0009840_abnormal_foam_cell1.47530162
21MP0000751_myopathy1.46576454
22MP0000537_abnormal_urethra_morphology1.45718475
23MP0005409_darkened_coat_color1.45587129
24MP0005257_abnormal_intraocular_pressure1.44760386
25MP0000467_abnormal_esophagus_morphology1.40726395
26MP0005501_abnormal_skin_physiology1.39401356
27MP0003283_abnormal_digestive_organ1.38503580
28MP0002060_abnormal_skin_morphology1.36688059
29MP0004233_abnormal_muscle_weight1.35643352
30MP0001542_abnormal_bone_strength1.31721840
31MP0001299_abnormal_eye_distance/1.29554111
32MP0003436_decreased_susceptibility_to1.27471239
33MP0004264_abnormal_extraembryonic_tissu1.27318968
34MP0005220_abnormal_exocrine_pancreas1.26187771
35MP0005058_abnormal_lysosome_morphology1.25285131
36MP0002139_abnormal_hepatobiliary_system1.24055423
37MP0003252_abnormal_bile_duct1.23329633
38MP0000685_abnormal_immune_system1.22162821
39MP0009278_abnormal_bone_marrow1.21817286
40MP0005451_abnormal_body_composition1.19914475
41MP0001958_emphysema1.18838048
42MP0000534_abnormal_ureter_morphology1.14998384
43MP0001243_abnormal_dermal_layer1.11210078
44MP0001216_abnormal_epidermal_layer1.08152665
45MP0002896_abnormal_bone_mineralization1.07772940
46MP0000013_abnormal_adipose_tissue1.07410784
47MP0001533_abnormal_skeleton_physiology1.05990997
48MP0003385_abnormal_body_wall1.05609431
49MP0004947_skin_inflammation1.04563919
50MP0003091_abnormal_cell_migration1.02772628
51MP0005365_abnormal_bile_salt1.02085207
52MP0002295_abnormal_pulmonary_circulatio1.02014257
53MP0005508_abnormal_skeleton_morphology1.01992676
54MP0003045_fibrosis1.01529710
55* MP0000858_altered_metastatic_potential1.01368846
56MP0005083_abnormal_biliary_tract1.00882640
57MP0008260_abnormal_autophagy1.00228455
58MP0005197_abnormal_uvea_morphology0.99875674
59MP0009780_abnormal_chondrocyte_physiolo0.99674059
60MP0002138_abnormal_hepatobiliary_system0.98204639
61MP0000733_abnormal_muscle_development0.98152233
62MP0006138_congestive_heart_failure0.97906374
63MP0003806_abnormal_nucleotide_metabolis0.97757858
64MP0002166_altered_tumor_susceptibility0.95389599
65MP0001944_abnormal_pancreas_morphology0.95307115
66MP0001835_abnormal_antigen_presentation0.94935016
67MP0010368_abnormal_lymphatic_system0.94491251
68MP0010771_integument_phenotype0.94318991
69MP0009384_cardiac_valve_regurgitation0.93242460
70MP0000003_abnormal_adipose_tissue0.92603997
71MP0003191_abnormal_cellular_cholesterol0.91943330
72MP0002089_abnormal_postnatal_growth/wei0.91692703
73MP0005390_skeleton_phenotype0.91664372
74MP0004808_abnormal_hematopoietic_stem0.91639681
75MP0004185_abnormal_adipocyte_glucose0.91445462
76MP0003693_abnormal_embryo_hatching0.91242704
77MP0001915_intracranial_hemorrhage0.91090522
78* MP0001614_abnormal_blood_vessel0.90746815
79MP0009053_abnormal_anal_canal0.90639051
80MP0000750_abnormal_muscle_regeneration0.90183215
81MP0000598_abnormal_liver_morphology0.89407899
82MP0001849_ear_inflammation0.89160989
83MP0009250_abnormal_appendicular_skeleto0.89117225
84MP0000609_abnormal_liver_physiology0.88796144
85MP0000428_abnormal_craniofacial_morphol0.88715254
86MP0002693_abnormal_pancreas_physiology0.87330402
87* MP0000767_abnormal_smooth_muscle0.87177602
88MP0002396_abnormal_hematopoietic_system0.86544692
89MP0005397_hematopoietic_system_phenotyp0.86478849
90MP0001545_abnormal_hematopoietic_system0.86478849
91* MP0010307_abnormal_tumor_latency0.85620374
92MP0009643_abnormal_urine_homeostasis0.84497559
93MP0009333_abnormal_splenocyte_physiolog0.82535011
94MP0003448_altered_tumor_morphology0.82023434
95MP0002254_reproductive_system_inflammat0.81488727
96MP0002108_abnormal_muscle_morphology0.81318114
97MP0002933_joint_inflammation0.81120807
98MP0002168_other_aberrant_phenotype0.80871230
99MP0002928_abnormal_bile_duct0.80473159
100* MP0002925_abnormal_cardiovascular_devel0.80181800
101MP0010234_abnormal_vibrissa_follicle0.80020280
102* MP0002086_abnormal_extraembryonic_tissu0.79850505
103MP0003942_abnormal_urinary_system0.79051588
104MP0003172_abnormal_lysosome_physiology0.78337834
105MP0004197_abnormal_fetal_growth/weight/0.78137483
106MP0003795_abnormal_bone_structure0.78121378
107MP0003453_abnormal_keratinocyte_physiol0.77883182
108MP0000432_abnormal_head_morphology0.77256484
109* MP0000759_abnormal_skeletal_muscle0.77070160
110MP0003755_abnormal_palate_morphology0.76947158
111MP0005464_abnormal_platelet_physiology0.75610249
112MP0005623_abnormal_meninges_morphology0.75086300
113MP0005193_abnormal_anterior_eye0.74850906
114MP0002128_abnormal_blood_circulation0.74593472
115MP0005085_abnormal_gallbladder_physiolo0.74129685
116MP0001348_abnormal_lacrimal_gland0.73776762
117MP0005375_adipose_tissue_phenotype0.73695793
118* MP0005621_abnormal_cell_physiology0.73612887
119MP0010030_abnormal_orbit_morphology0.73466994
120MP0002932_abnormal_joint_morphology0.73129587
121MP0005360_urolithiasis0.72947531
122MP0002088_abnormal_embryonic_growth/wei0.72579293
123MP0002697_abnormal_eye_size0.72339338
124* MP0005595_abnormal_vascular_smooth0.71891455
125MP0003984_embryonic_growth_retardation0.71703597
126MP0003828_pulmonary_edema0.71327392
127MP0000462_abnormal_digestive_system0.71147123
128MP0004957_abnormal_blastocyst_morpholog0.71096763
129MP0009931_abnormal_skin_appearance0.70723301
130MP0003195_calcinosis0.70708663
131MP0003115_abnormal_respiratory_system0.70350713
132MP0000371_diluted_coat_color0.70273473
133MP0003724_increased_susceptibility_to0.69888366
134MP0010155_abnormal_intestine_physiology0.69710419
135MP0000350_abnormal_cell_proliferation0.69307961
136MP0005164_abnormal_response_to0.69117343
137MP0000490_abnormal_crypts_of0.68113991
138MP0008007_abnormal_cellular_replicative0.68100373
139MP0002419_abnormal_innate_immunity0.68057694
140MP0001845_abnormal_inflammatory_respons0.68055897
141MP0002113_abnormal_skeleton_development0.68015486
142MP0002998_abnormal_bone_remodeling0.67867111
143MP0005319_abnormal_enzyme/_coenzyme0.67418011
144MP0001730_embryonic_growth_arrest0.67277765
145MP0002405_respiratory_system_inflammati0.66875910
146MP0000678_abnormal_parathyroid_gland0.66233862
147MP0003935_abnormal_craniofacial_develop0.66168738
148MP0001879_abnormal_lymphatic_vessel0.65706182
149MP0005165_increased_susceptibility_to0.65651412
150MP0003303_peritoneal_inflammation0.65363370
151MP0001790_abnormal_immune_system0.64950780
152MP0000163_abnormal_cartilage_morphology0.64211130
153MP0004782_abnormal_surfactant_physiolog0.62888052

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.89832331
2Premature rupture of membranes (HP:0001788)4.07852248
3Vascular tortuosity (HP:0004948)3.71062610
4Arterial tortuosity (HP:0005116)3.69559494
5Cerebral aneurysm (HP:0004944)3.39193388
6Cervical subluxation (HP:0003308)3.34561054
7Ankle contracture (HP:0006466)3.31220917
8Hypoglycemic coma (HP:0001325)3.14164672
9Peritonitis (HP:0002586)3.09284860
10Abnormality of dentin (HP:0010299)3.02301541
11Follicular hyperkeratosis (HP:0007502)2.87293191
12Aortic aneurysm (HP:0004942)2.83833667
13Vertebral compression fractures (HP:0002953)2.76657629
14Aortic dissection (HP:0002647)2.74027394
15Short nail (HP:0001799)2.72685043
16Hyperinsulinemic hypoglycemia (HP:0000825)2.71170853
17Hypoglycemic seizures (HP:0002173)2.67334689
18Natal tooth (HP:0000695)2.66549765
19Distal lower limb amyotrophy (HP:0008944)2.56256518
20Dilatation of the ascending aorta (HP:0005111)2.55705696
21Aneurysm (HP:0002617)2.54818513
22Elbow flexion contracture (HP:0002987)2.54119599
23Mildly elevated creatine phosphokinase (HP:0008180)2.50927693
24Achilles tendon contracture (HP:0001771)2.44472091
25Hyperacusis (HP:0010780)2.42846341
26Shallow orbits (HP:0000586)2.41656917
27Mitral valve prolapse (HP:0001634)2.39242603
28Disproportionate tall stature (HP:0001519)2.38910405
29Milia (HP:0001056)2.37911073
30Atrophic scars (HP:0001075)2.37481513
31Type 1 muscle fiber predominance (HP:0003803)2.36971939
32Soft skin (HP:0000977)2.35207808
33Fragile nails (HP:0001808)2.34190306
34Mucopolysacchariduria (HP:0008155)2.33732048
35Urinary glycosaminoglycan excretion (HP:0003541)2.33732048
36Osteolytic defects of the hand bones (HP:0009699)2.30232586
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.30232586
38Trismus (HP:0000211)2.29085091
39Pterygium (HP:0001059)2.25007090
40Blue sclerae (HP:0000592)2.23004006
41Joint laxity (HP:0001388)2.22533801
42Increased variability in muscle fiber diameter (HP:0003557)2.22431982
43Distal lower limb muscle weakness (HP:0009053)2.19907510
44Abnormality of the intrinsic pathway (HP:0010989)2.19741861
45Abnormality of endocrine pancreas physiology (HP:0012093)2.19066450
46Abnormality of the pancreatic islet cells (HP:0006476)2.19066450
47Ulnar bowing (HP:0003031)2.18517605
48Abnormality of the Achilles tendon (HP:0005109)2.17496002
49Neonatal short-limb short stature (HP:0008921)2.16939624
50Spondylolisthesis (HP:0003302)2.16778882
51Abnormality of the common coagulation pathway (HP:0010990)2.16409749
52Mitral regurgitation (HP:0001653)2.15628750
53Bladder diverticulum (HP:0000015)2.14368270
54Thoracolumbar scoliosis (HP:0002944)2.12861755
55Increased connective tissue (HP:0009025)2.12553696
56Difficulty climbing stairs (HP:0003551)2.11917064
57Myocardial infarction (HP:0001658)2.10866159
58Symptomatic seizures (HP:0011145)2.10845058
59Thin bony cortex (HP:0002753)2.09318695
60Abnormality of polysaccharide metabolism (HP:0011012)2.06677079
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06677079
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06677079
63Pancreatic islet-cell hyperplasia (HP:0004510)2.06539312
64Abnormal delivery (HP:0001787)2.06285576
65Abnormality of skeletal muscle fiber size (HP:0012084)2.06041532
66Abnormality of oral frenula (HP:0000190)2.05838514
67Ankyloglossia (HP:0010296)2.05179888
68Hyperglycemia (HP:0003074)2.05075452
69Hyperextensible skin (HP:0000974)2.04789958
70Wormian bones (HP:0002645)2.03646674
71Biconcave vertebral bodies (HP:0004586)2.03625615
72Genu recurvatum (HP:0002816)2.02840075
73Dysostosis multiplex (HP:0000943)2.01933506
74Broad metatarsal (HP:0001783)2.00458055
75Nonimmune hydrops fetalis (HP:0001790)1.99479147
76Alopecia of scalp (HP:0002293)1.99384767
77Broad face (HP:0000283)1.99112118
78Insulin resistance (HP:0000855)1.98947652
79Advanced eruption of teeth (HP:0006288)1.98761871
80Slender build (HP:0001533)1.98283067
81Abnormality of monocarboxylic acid metabolism (HP:0010996)1.95191378
82Onycholysis (HP:0001806)1.95124209
83Hematochezia (HP:0002573)1.94783941
84Abnormality of the acetabulum (HP:0003170)1.94759139
85Coxa vara (HP:0002812)1.94689469
86Thick nail (HP:0001805)1.93726412
87Abnormality of the distal phalanges of the toes (HP:0010182)1.91946816
88Lower limb amyotrophy (HP:0007210)1.91299550
89Joint stiffness (HP:0001387)1.90296944
90Hand muscle atrophy (HP:0009130)1.90256654
91Cardiovascular calcification (HP:0011915)1.90060033
92Aortic regurgitation (HP:0001659)1.89974195
93Bowel diverticulosis (HP:0005222)1.89944807
94Long toe (HP:0010511)1.89084925
95Fragile skin (HP:0001030)1.89001741
96Camptodactyly of toe (HP:0001836)1.86025027
97Flat acetabular roof (HP:0003180)1.85659113
98Late onset (HP:0003584)1.84981571
99Nail dystrophy (HP:0008404)1.84809472
100Entropion (HP:0000621)1.83603080
101Overgrowth (HP:0001548)1.82705493
102Aortic valve stenosis (HP:0001650)1.79670069
103Striae distensae (HP:0001065)1.79538276
104Spinal rigidity (HP:0003306)1.78583652
105Insulin-resistant diabetes mellitus (HP:0000831)1.77742548
106Xanthomatosis (HP:0000991)1.77432258
107Radial bowing (HP:0002986)1.77151831
108Reduced subcutaneous adipose tissue (HP:0003758)1.76415271
109Abnormality of nail color (HP:0100643)1.76158382
110Long palpebral fissure (HP:0000637)1.75819324
111Back pain (HP:0003418)1.74299510
112Abnormal ossification of hand bones (HP:0005921)1.73888314
113Abnormal cartilage morphology (HP:0002763)1.73692041
114Enlarged penis (HP:0000040)1.73686160
115Spinal cord lesions (HP:0100561)1.72786186
116Syringomyelia (HP:0003396)1.72786186
117Hypoventilation (HP:0002791)1.72125371
118Abnormality of the peritoneum (HP:0002585)1.71338902
119Deep venous thrombosis (HP:0002625)1.71312309
120Abnormality of carpal bone ossification (HP:0006257)1.71057506
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70956138
122Coronal craniosynostosis (HP:0004440)1.70567315
123Upper limb amyotrophy (HP:0009129)1.70265433
124Distal upper limb amyotrophy (HP:0007149)1.70265433
125Bowing of the arm (HP:0006488)1.69639035
126Bowed forearm bones (HP:0003956)1.69639035
127Abnormality of aromatic amino acid family metabolism (HP:0004338)1.69340150
128Increased density of long bones (HP:0006392)1.68539783
129Eczematoid dermatitis (HP:0000976)1.68521392
130Delayed cranial suture closure (HP:0000270)1.68012655
131Skin nodule (HP:0200036)1.67986833
132Mitral stenosis (HP:0001718)1.66111262
133Interstitial pulmonary disease (HP:0006530)1.64746111
134Ectopia lentis (HP:0001083)1.64601066
135Persistence of primary teeth (HP:0006335)1.64200077
136Generalized amyotrophy (HP:0003700)1.63734212
137Platyspondyly (HP:0000926)1.62636865
138Hypercortisolism (HP:0001578)1.61395482
139Increased mean platelet volume (HP:0011877)1.60731360
140Abnormality of the calcaneus (HP:0008364)1.59270940
141Esophageal varix (HP:0002040)1.58902607
142Vacuolated lymphocytes (HP:0001922)1.58777147
143Wrist flexion contracture (HP:0001239)1.56710126
144Beaking of vertebral bodies (HP:0004568)1.55491951
145Periodontitis (HP:0000704)1.52920878
146Thrombocytosis (HP:0001894)1.52840171
147Subacute progressive viral hepatitis (HP:0006572)1.52001159
148Vertebral hypoplasia (HP:0008417)1.51985915
149Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.51985915
150Metaphyseal cupping (HP:0003021)1.49970447
151Tetraparesis (HP:0002273)1.49463258
152Ketoacidosis (HP:0001993)1.49433655
153Selective tooth agenesis (HP:0001592)1.48933059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.93516421
2ERN13.79049336
3PKN22.99019001
4EEF2K2.42857939
5SMG12.42577304
6EPHB22.27599763
7MAP3K102.20823582
8PASK2.15792882
9SIK12.12574502
10MYLK2.07535222
11TTN2.06350990
12INSRR2.01346828
13ICK1.95288153
14PTK61.94767855
15TAOK31.85940921
16CDK121.75074556
17ERBB41.73840929
18RIPK11.73619017
19EPHA21.73427881
20EPHA31.72992986
21STK101.70801986
22RPS6KA41.65465230
23LRRK21.61828082
24LMTK21.60133589
25LATS11.59750133
26LIMK11.47879219
27FGFR41.44478958
28DDR21.43770818
29SCYL21.40765804
30MOS1.40654986
31MAP2K31.36628646
32TIE11.35353908
33PRKD21.32185297
34PAK41.30422881
35* MET1.30289554
36ARAF1.27473521
37TYK21.27137352
38TGFBR21.20971632
39PRPF4B1.20564581
40NEK91.20117557
41PIM21.16996909
42TRPM71.14954510
43* PDGFRA1.14765983
44MAP3K31.12709367
45STK31.12614839
46TBK11.11444688
47KDR1.08057986
48EPHB11.07323450
49MAP3K81.07100899
50STK381.06424725
51BRSK21.05896513
52MTOR1.05830765
53PAK21.05325536
54MAPKAPK31.05170903
55RPS6KB21.04023716
56CDC42BPA1.03577238
57* PTK21.00151024
58MAP4K10.96126871
59HIPK20.95709138
60JAK10.94796434
61TGFBR10.94319414
62CHUK0.94179686
63MAP3K60.91684541
64CDK60.91091533
65BMX0.89302703
66NEK20.89124803
67RPS6KA20.88678902
68NME20.88142287
69MAPK150.86033244
70PIM10.85380077
71TESK10.81778929
72MAP2K20.80480866
73ABL20.78415778
74CSK0.78219224
75TAOK20.77039932
76CDK80.76525379
77IKBKB0.76290294
78MAP3K140.75734838
79DYRK1B0.74816492
80* JAK30.73150250
81BCKDK0.70592229
82ROCK20.68575078
83KSR20.68302149
84PIK3CG0.68024197
85PTK2B0.67411777
86BTK0.67351325
87MELK0.66876279
88MAP3K130.66715467
89CDK70.66599553
90FGFR30.66467428
91JAK20.66364819
92FRK0.65381668
93CAMK1D0.65003798
94IRAK30.63696258
95CDK90.62212408
96CDK40.61842879
97MAP3K90.61380333
98RET0.60561919
99FER0.59341692
100PBK0.59018400
101KIT0.57912371
102LATS20.57609437
103BRAF0.57280424
104STK40.56319997
105ITK0.53968690
106MAPKAPK20.53876479
107CLK10.53872366
108GSK3A0.53513548
109PRKG20.53022975
110BUB10.52792372
111* NTRK10.52752515
112ILK0.52725096
113PRKD30.52096663
114PAK10.52053770
115DMPK0.52014332
116MAPK110.51633033
117NLK0.50522100
118TTK0.49392565
119ROCK10.49141680
120CSF1R0.47150124
121MATK0.46840839
122MAP3K110.46839982
123DAPK30.46664152
124FGFR10.45703678
125MST1R0.44517211
126TESK20.43988964
127MAP2K10.43709869
128BRSK10.41600439
129* ZAP700.40802263
130ALK0.40306136
131MARK30.40288405
132AURKB0.39823299
133PDPK10.39701714
134MAP3K10.39504619
135RPS6KA60.39309040
136* FLT30.38338798
137RPS6KC10.38171658
138RPS6KL10.38171658
139* PDGFRB0.35159782
140NEK10.34967434
141TEC0.34502578
142MAPK70.31611904
143AKT20.30787098
144MARK20.29831437
145* SRC0.27924232

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.07218875
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.38425011
3Selenocompound metabolism_Homo sapiens_hsa004501.89853242
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.86660006
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.85262536
6One carbon pool by folate_Homo sapiens_hsa006701.84512982
7Protein export_Homo sapiens_hsa030601.56523295
8Regulation of actin cytoskeleton_Homo sapiens_hsa048101.53388242
9Bladder cancer_Homo sapiens_hsa052191.51290761
10Legionellosis_Homo sapiens_hsa051341.45745973
11Prion diseases_Homo sapiens_hsa050201.44730356
12Antigen processing and presentation_Homo sapiens_hsa046121.39567088
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.34056877
14Small cell lung cancer_Homo sapiens_hsa052221.34002012
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33763926
16ECM-receptor interaction_Homo sapiens_hsa045121.33550664
17* Chronic myeloid leukemia_Homo sapiens_hsa052201.30889751
18Dilated cardiomyopathy_Homo sapiens_hsa054141.28170319
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26390447
20Insulin resistance_Homo sapiens_hsa049311.21682018
21Leishmaniasis_Homo sapiens_hsa051401.21650315
22Lysosome_Homo sapiens_hsa041421.19703357
23Tryptophan metabolism_Homo sapiens_hsa003801.19680133
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19248310
25Adherens junction_Homo sapiens_hsa045201.18975825
26p53 signaling pathway_Homo sapiens_hsa041151.18523263
27Folate biosynthesis_Homo sapiens_hsa007901.18062818
28* Focal adhesion_Homo sapiens_hsa045101.17573661
29Galactose metabolism_Homo sapiens_hsa000521.16448057
30Thyroid cancer_Homo sapiens_hsa052161.15016722
31Proteoglycans in cancer_Homo sapiens_hsa052051.14653491
32Caffeine metabolism_Homo sapiens_hsa002321.13716604
33Complement and coagulation cascades_Homo sapiens_hsa046101.12879010
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11532448
35Pathways in cancer_Homo sapiens_hsa052001.11334138
36Lysine degradation_Homo sapiens_hsa003101.09633912
37Apoptosis_Homo sapiens_hsa042101.08952779
38Toxoplasmosis_Homo sapiens_hsa051451.08505661
39VEGF signaling pathway_Homo sapiens_hsa043701.07574729
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05906852
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.05732470
42N-Glycan biosynthesis_Homo sapiens_hsa005101.05308416
43Other glycan degradation_Homo sapiens_hsa005111.04614714
44Viral carcinogenesis_Homo sapiens_hsa052031.03686148
45* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03236671
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.03176915
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03156662
48Amoebiasis_Homo sapiens_hsa051461.02029749
49Staphylococcus aureus infection_Homo sapiens_hsa051501.01894760
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01590625
51Fructose and mannose metabolism_Homo sapiens_hsa000511.01374833
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01149635
53Renal cell carcinoma_Homo sapiens_hsa052111.00026875
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99757356
55Sulfur metabolism_Homo sapiens_hsa009200.98777371
56Fatty acid degradation_Homo sapiens_hsa000710.97658715
57Basal cell carcinoma_Homo sapiens_hsa052170.97409987
58Acute myeloid leukemia_Homo sapiens_hsa052210.97235730
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.96115853
60Melanoma_Homo sapiens_hsa052180.94832482
61Tight junction_Homo sapiens_hsa045300.93416754
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92689444
63Axon guidance_Homo sapiens_hsa043600.92434771
64Malaria_Homo sapiens_hsa051440.89793127
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89205089
66Pancreatic cancer_Homo sapiens_hsa052120.88833431
67* MicroRNAs in cancer_Homo sapiens_hsa052060.88648238
68Measles_Homo sapiens_hsa051620.88423662
69Non-small cell lung cancer_Homo sapiens_hsa052230.88245834
70TNF signaling pathway_Homo sapiens_hsa046680.87973832
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.87729698
72Starch and sucrose metabolism_Homo sapiens_hsa005000.87690833
73Endometrial cancer_Homo sapiens_hsa052130.86305622
74Vibrio cholerae infection_Homo sapiens_hsa051100.84280287
75Hepatitis B_Homo sapiens_hsa051610.83346885
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83236834
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.82964632
78Prostate cancer_Homo sapiens_hsa052150.81218675
79Shigellosis_Homo sapiens_hsa051310.81036467
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80400207
81mTOR signaling pathway_Homo sapiens_hsa041500.79415561
82Herpes simplex infection_Homo sapiens_hsa051680.78110252
83Endocytosis_Homo sapiens_hsa041440.76859520
84Osteoclast differentiation_Homo sapiens_hsa043800.75746649
85HTLV-I infection_Homo sapiens_hsa051660.74740018
86Protein digestion and absorption_Homo sapiens_hsa049740.73552086
87TGF-beta signaling pathway_Homo sapiens_hsa043500.73341596
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.72621135
89Rap1 signaling pathway_Homo sapiens_hsa040150.71973891
90Viral myocarditis_Homo sapiens_hsa054160.71237659
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70416707
92Arginine biosynthesis_Homo sapiens_hsa002200.69533120
93* Glioma_Homo sapiens_hsa052140.68966556
94Salmonella infection_Homo sapiens_hsa051320.68647657
95Cell cycle_Homo sapiens_hsa041100.67334832
96Pertussis_Homo sapiens_hsa051330.66751512
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66719251
98* Insulin signaling pathway_Homo sapiens_hsa049100.66319885
99Fat digestion and absorption_Homo sapiens_hsa049750.66273211
100Pentose phosphate pathway_Homo sapiens_hsa000300.65871340
101Hedgehog signaling pathway_Homo sapiens_hsa043400.65036201
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.64952253
103Renin-angiotensin system_Homo sapiens_hsa046140.64220152
104Phenylalanine metabolism_Homo sapiens_hsa003600.64074652
105Influenza A_Homo sapiens_hsa051640.63494391
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.62165655
107Biosynthesis of amino acids_Homo sapiens_hsa012300.61668215
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61345213
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59772177
110Melanogenesis_Homo sapiens_hsa049160.59701340
111* ErbB signaling pathway_Homo sapiens_hsa040120.59175165
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59078053
113Notch signaling pathway_Homo sapiens_hsa043300.58934421
114* Prolactin signaling pathway_Homo sapiens_hsa049170.58816470
115* Neurotrophin signaling pathway_Homo sapiens_hsa047220.58725106
116Colorectal cancer_Homo sapiens_hsa052100.57250279
117Carbon metabolism_Homo sapiens_hsa012000.56297175
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56009129
119PPAR signaling pathway_Homo sapiens_hsa033200.55082620
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54462051
121Wnt signaling pathway_Homo sapiens_hsa043100.53932383
122Vitamin B6 metabolism_Homo sapiens_hsa007500.53877333
123ABC transporters_Homo sapiens_hsa020100.53634681
124AMPK signaling pathway_Homo sapiens_hsa041520.53249648
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53131738
126Sulfur relay system_Homo sapiens_hsa041220.52577831
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51857982
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51798652
129* Phospholipase D signaling pathway_Homo sapiens_hsa040720.51502050
130Gap junction_Homo sapiens_hsa045400.50257425
131Tuberculosis_Homo sapiens_hsa051520.49735329
132RNA transport_Homo sapiens_hsa030130.49149579
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48414140
134Platelet activation_Homo sapiens_hsa046110.48039718
135HIF-1 signaling pathway_Homo sapiens_hsa040660.47875372
136Hepatitis C_Homo sapiens_hsa051600.47013131
137Epstein-Barr virus infection_Homo sapiens_hsa051690.46576002
138Hippo signaling pathway_Homo sapiens_hsa043900.46395168
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44320708
140Inositol phosphate metabolism_Homo sapiens_hsa005620.43509727
141Sphingolipid metabolism_Homo sapiens_hsa006000.43456603
142GnRH signaling pathway_Homo sapiens_hsa049120.42276754
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42076994

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »