SHC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.41266978
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.16843984
3synaptic vesicle maturation (GO:0016188)4.94648709
4vocalization behavior (GO:0071625)4.74304357
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.66937422
6locomotory exploration behavior (GO:0035641)4.66088606
7neuron cell-cell adhesion (GO:0007158)4.54635710
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.50358794
9glutamate secretion (GO:0014047)4.48340607
10protein localization to synapse (GO:0035418)4.45287284
11synaptic vesicle exocytosis (GO:0016079)4.40357965
12regulation of synaptic vesicle exocytosis (GO:2000300)4.37238897
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.35726020
14regulation of glutamate receptor signaling pathway (GO:1900449)4.24236383
15layer formation in cerebral cortex (GO:0021819)4.18821111
16axonal fasciculation (GO:0007413)4.01086201
17cell migration in hindbrain (GO:0021535)3.97231962
18neuronal action potential propagation (GO:0019227)3.96828533
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.91974498
20exploration behavior (GO:0035640)3.91118552
21dendritic spine morphogenesis (GO:0060997)3.90808709
22neuron recognition (GO:0008038)3.88280578
23regulation of synaptic vesicle transport (GO:1902803)3.86584945
24axon ensheathment in central nervous system (GO:0032291)3.79809675
25central nervous system myelination (GO:0022010)3.79809675
26regulation of neuronal synaptic plasticity (GO:0048168)3.77053278
27neurotransmitter secretion (GO:0007269)3.74131807
28proline transport (GO:0015824)3.66527322
29positive regulation of synaptic transmission, GABAergic (GO:0032230)3.63120765
30synaptic transmission, glutamatergic (GO:0035249)3.62075643
31glutamate receptor signaling pathway (GO:0007215)3.57369639
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.56957477
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.52427155
34membrane depolarization during action potential (GO:0086010)3.49241544
35postsynaptic membrane organization (GO:0001941)3.47229948
36regulation of synapse structural plasticity (GO:0051823)3.45987709
37dendrite morphogenesis (GO:0048813)3.42300218
38innervation (GO:0060384)3.41988405
39positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.35109953
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33267411
41neuron-neuron synaptic transmission (GO:0007270)3.31095569
42pyrimidine nucleobase catabolic process (GO:0006208)3.29517856
43cerebellar Purkinje cell differentiation (GO:0021702)3.28910119
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28496095
45neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.27015276
46activation of protein kinase A activity (GO:0034199)3.23180665
47regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22889082
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21767552
49synaptic vesicle endocytosis (GO:0048488)3.18448819
50regulation of vesicle fusion (GO:0031338)3.14676745
51central nervous system projection neuron axonogenesis (GO:0021952)3.13528064
52neuromuscular process controlling balance (GO:0050885)3.13522033
53transmission of nerve impulse (GO:0019226)3.13312004
54regulation of postsynaptic membrane potential (GO:0060078)3.12890672
55positive regulation of synapse maturation (GO:0090129)3.12035267
56long-term memory (GO:0007616)3.11832118
57neurotransmitter-gated ion channel clustering (GO:0072578)3.09585392
58negative regulation of microtubule polymerization (GO:0031115)3.08905331
59regulation of neurotransmitter secretion (GO:0046928)3.08064806
60neurotransmitter transport (GO:0006836)3.02122974
61membrane depolarization (GO:0051899)2.99578708
62cell communication by electrical coupling (GO:0010644)2.99184963
63regulation of synaptic transmission, glutamatergic (GO:0051966)2.98429051
64gamma-aminobutyric acid transport (GO:0015812)2.98208748
65positive regulation of membrane potential (GO:0045838)2.97224032
66cerebellar granule cell differentiation (GO:0021707)2.97066584
67neuromuscular synaptic transmission (GO:0007274)2.93236296
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92574196
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.92391340
70neuronal ion channel clustering (GO:0045161)2.92268988
71cellular potassium ion homeostasis (GO:0030007)2.92223750
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.92120886
73regulation of synaptic plasticity (GO:0048167)2.91657192
74synapse assembly (GO:0007416)2.91199378
75presynaptic membrane assembly (GO:0097105)2.90669383
76regulation of dendritic spine morphogenesis (GO:0061001)2.86924657
77regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86708437
78cell-cell junction maintenance (GO:0045217)2.85986413
79auditory behavior (GO:0031223)2.83615080
80dendritic spine organization (GO:0097061)2.83427951
81cerebellar Purkinje cell layer development (GO:0021680)2.82506013
82positive regulation of synapse assembly (GO:0051965)2.81527778
83vesicle transport along microtubule (GO:0047496)2.80587270
84establishment of mitochondrion localization (GO:0051654)2.80159844
85regulation of neurotransmitter transport (GO:0051588)2.79102269
86positive regulation of neurotransmitter secretion (GO:0001956)2.78993380
87regulation of respiratory system process (GO:0044065)2.78099086
88neuromuscular process (GO:0050905)2.77880327
89mechanosensory behavior (GO:0007638)2.76099922
90regulation of synapse maturation (GO:0090128)2.75654145
91positive regulation of dendritic spine development (GO:0060999)2.75319380
92synapse organization (GO:0050808)2.75070418
93organelle transport along microtubule (GO:0072384)2.75001430
94chemosensory behavior (GO:0007635)2.74898089
95axon cargo transport (GO:0008088)2.73137194
96positive regulation of neurotransmitter transport (GO:0051590)2.73058682
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72121281
98neuronal action potential (GO:0019228)2.71715639
99regulation of neurotransmitter levels (GO:0001505)2.71472747
100social behavior (GO:0035176)2.71412280
101intraspecies interaction between organisms (GO:0051703)2.71412280
102mating behavior (GO:0007617)2.71338676
103negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.71091746
104neuromuscular process controlling posture (GO:0050884)2.69006349
105nucleobase catabolic process (GO:0046113)2.68563761
106presynaptic membrane organization (GO:0097090)2.68377109
107axon extension (GO:0048675)2.68342489
108response to auditory stimulus (GO:0010996)2.67778751
109G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.67512508
110learning (GO:0007612)2.67401688
111establishment of nucleus localization (GO:0040023)2.66554563
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.66142800
113triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.66093906
114mitochondrion transport along microtubule (GO:0047497)2.62342287
115establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62342287
116sodium ion export (GO:0071436)2.61183518
117cell junction maintenance (GO:0034331)2.49558067
118embryonic retina morphogenesis in camera-type eye (GO:0060059)2.43982948
119negative regulation of catenin import into nucleus (GO:0035414)2.42414351
120positive regulation of dendrite development (GO:1900006)2.42264712
121adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.39952498
122L-amino acid import (GO:0043092)2.39254061
123response to dietary excess (GO:0002021)2.37753077
124dopamine receptor signaling pathway (GO:0007212)2.36670934
125semaphorin-plexin signaling pathway (GO:0071526)2.36318896
126cellular sodium ion homeostasis (GO:0006883)2.33147420
127positive regulation of dendritic spine morphogenesis (GO:0061003)2.29703038
128regulation of voltage-gated calcium channel activity (GO:1901385)2.29374610
129potassium ion homeostasis (GO:0055075)2.27414589
130amino acid import (GO:0043090)2.26836307
131regulation of axon extension involved in axon guidance (GO:0048841)2.25150743
132potassium ion import (GO:0010107)2.21402395
133regulation of axonogenesis (GO:0050770)2.21058715
134negative regulation of axonogenesis (GO:0050771)2.20734345
135camera-type eye morphogenesis (GO:0048593)2.18988536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.08130758
2GBX2_23144817_ChIP-Seq_PC3_Human3.44529863
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10767453
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07291002
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95238019
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76094967
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.75930854
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74591656
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74591656
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63751595
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.63010452
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55367819
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54240305
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.51893041
15REST_21632747_ChIP-Seq_MESCs_Mouse2.50428280
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.47447151
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44765884
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42918540
19* DROSHA_22980978_ChIP-Seq_HELA_Human2.32980609
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.28600930
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.26927102
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21704334
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21579427
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.18052348
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17938752
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05339017
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99730892
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.98771599
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89216363
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76005005
31AR_21572438_ChIP-Seq_LNCaP_Human1.74669462
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70624750
33SMAD4_21799915_ChIP-Seq_A2780_Human1.60881158
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58389737
35ZNF274_21170338_ChIP-Seq_K562_Hela1.57294989
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56962909
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54774737
38LXR_22292898_ChIP-Seq_THP-1_Human1.52976930
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51879357
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.51615672
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.51455114
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50338922
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50065405
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50064325
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45537279
46* RING1B_27294783_Chip-Seq_ESCs_Mouse1.43439834
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41999346
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39942395
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36962215
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.34532020
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.34281073
52IGF1R_20145208_ChIP-Seq_DFB_Human1.33085947
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.30953698
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30351616
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.30337500
56TAF15_26573619_Chip-Seq_HEK293_Human1.27929149
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27669408
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27426249
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26288975
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25399603
61P300_19829295_ChIP-Seq_ESCs_Human1.25217798
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24393699
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23732636
64RNF2_27304074_Chip-Seq_NSC_Mouse1.23181595
65STAT3_23295773_ChIP-Seq_U87_Human1.23069482
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22630219
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22200779
68AR_19668381_ChIP-Seq_PC3_Human1.21163711
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.20290032
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.20200632
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19667014
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18450385
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17914945
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16015482
75AR_25329375_ChIP-Seq_VCAP_Human1.15386029
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13128853
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13084145
78AHR_22903824_ChIP-Seq_MCF-7_Human1.12549690
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12501868
80* KDM2B_26808549_Chip-Seq_K562_Human1.12434901
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10058882
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09280977
83TET1_21490601_ChIP-Seq_MESCs_Mouse1.09037962
84NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06218403
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.05653203
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04279304
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03991434
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.03921388
89SMC4_20622854_ChIP-Seq_HELA_Human1.02878007
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02409056
91* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01896413
92* TCF4_23295773_ChIP-Seq_U87_Human1.01879995
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01327650
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99956222
95* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99710227
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99580935
97TP53_20018659_ChIP-ChIP_R1E_Mouse0.99319068
98RUNX2_22187159_ChIP-Seq_PCA_Human0.98802379
99SMAD_19615063_ChIP-ChIP_OVARY_Human0.98744417
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98598023
101SMAD4_21741376_ChIP-Seq_HESCs_Human0.98587640
102* CREB1_26743006_Chip-Seq_LNCaP_Human0.98150034
103* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97684662
104EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97180348
105P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95876308
106SMAD3_21741376_ChIP-Seq_ESCs_Human0.95284543
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95154761
108* P68_20966046_ChIP-Seq_HELA_Human0.94435229
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93795728
110NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93347927
111FUS_26573619_Chip-Seq_HEK293_Human0.92003906
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89347663
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89004860
114EP300_21415370_ChIP-Seq_HL-1_Mouse0.88901853
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88485232
116TP53_16413492_ChIP-PET_HCT116_Human0.87190228
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86893302
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86585919
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86557145
120CTCF_27219007_Chip-Seq_Bcells_Human0.86539295
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86217866
122* OCT4_19829295_ChIP-Seq_ESCs_Human0.86136104
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86002055
124* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.85920973
125* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85822826
126STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85414170
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85343891
128MYC_27129775_Chip-Seq_CORNEA_Mouse0.84100129
129* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82184602
130* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81586914
131KDM2B_26808549_Chip-Seq_DND41_Human0.80535027
132* KLF4_19829295_ChIP-Seq_ESCs_Human0.79244659
133TET1_21451524_ChIP-Seq_MESCs_Mouse0.78527459
134POU5F1_16518401_ChIP-PET_MESCs_Mouse0.78086804
135TP53_23651856_ChIP-Seq_MEFs_Mouse0.75178683
136FOXA2_19822575_ChIP-Seq_HepG2_Human0.75098550
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.74786248
138SA1_27219007_Chip-Seq_ERYTHROID_Human0.74619982
139RXR_22158963_ChIP-Seq_LIVER_Mouse0.73668302
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73320007
141GATA1_26923725_Chip-Seq_HPCs_Mouse0.72898136
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68777153
143DPY_21335234_ChIP-Seq_ESCs_Mouse0.68139958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.48214558
2MP0003880_abnormal_central_pattern4.08842576
3MP0004270_analgesia3.67920874
4MP0003635_abnormal_synaptic_transmissio3.55116832
5MP0001968_abnormal_touch/_nociception3.37199265
6MP0002735_abnormal_chemical_nociception2.99440968
7MP0002063_abnormal_learning/memory/cond2.81399917
8MP0009745_abnormal_behavioral_response2.75772719
9MP0002734_abnormal_mechanical_nocicepti2.73880196
10MP0002822_catalepsy2.59861660
11MP0002736_abnormal_nociception_after2.56823163
12MP0005423_abnormal_somatic_nervous2.56602633
13MP0006276_abnormal_autonomic_nervous2.46364687
14MP0002064_seizures2.45995622
15MP0004858_abnormal_nervous_system2.40066720
16MP0002572_abnormal_emotion/affect_behav2.37933994
17MP0002733_abnormal_thermal_nociception2.36909864
18MP0003283_abnormal_digestive_organ2.25905357
19MP0009046_muscle_twitch2.24924034
20MP0002272_abnormal_nervous_system2.16142188
21MP0001970_abnormal_pain_threshold2.09828176
22MP0002184_abnormal_innervation2.07309495
23MP0003122_maternal_imprinting2.03206910
24MP0000778_abnormal_nervous_system1.99783295
25MP0001486_abnormal_startle_reflex1.92040944
26MP0009780_abnormal_chondrocyte_physiolo1.87345628
27MP0000566_synostosis1.85435744
28MP0005409_darkened_coat_color1.80713235
29MP0002067_abnormal_sensory_capabilities1.80471690
30MP0004811_abnormal_neuron_physiology1.77312803
31MP0001440_abnormal_grooming_behavior1.75764661
32MP0002909_abnormal_adrenal_gland1.69651608
33MP0000955_abnormal_spinal_cord1.69230849
34MP0001501_abnormal_sleep_pattern1.67943029
35MP0002249_abnormal_larynx_morphology1.64070567
36MP0002557_abnormal_social/conspecific_i1.59417877
37MP0010386_abnormal_urinary_bladder1.57175516
38MP0003787_abnormal_imprinting1.48729626
39MP0003690_abnormal_glial_cell1.44450211
40MP0004924_abnormal_behavior1.44422779
41MP0005386_behavior/neurological_phenoty1.44422779
42MP0005167_abnormal_blood-brain_barrier1.42509155
43* MP0002882_abnormal_neuron_morphology1.40395843
44MP0003329_amyloid_beta_deposits1.37367886
45MP0005646_abnormal_pituitary_gland1.35800367
46MP0005645_abnormal_hypothalamus_physiol1.35154173
47MP0000569_abnormal_digit_pigmentation1.32782876
48MP0008569_lethality_at_weaning1.32726319
49MP0003879_abnormal_hair_cell1.30144797
50MP0001188_hyperpigmentation1.28642231
51MP0000751_myopathy1.27589813
52MP0002066_abnormal_motor_capabilities/c1.25291661
53MP0004145_abnormal_muscle_electrophysio1.24253014
54MP0001984_abnormal_olfaction1.20786768
55MP0005670_abnormal_white_adipose1.18323799
56MP0010368_abnormal_lymphatic_system1.13886498
57MP0001299_abnormal_eye_distance/1.12718413
58MP0005623_abnormal_meninges_morphology1.10467931
59MP0002152_abnormal_brain_morphology1.10202369
60MP0002234_abnormal_pharynx_morphology1.10006502
61MP0003938_abnormal_ear_development1.09458570
62MP0009379_abnormal_foot_pigmentation1.08276438
63MP0003136_yellow_coat_color1.08109169
64MP0000631_abnormal_neuroendocrine_gland1.07944072
65MP0001905_abnormal_dopamine_level1.06825475
66MP0002139_abnormal_hepatobiliary_system1.05982253
67MP0002653_abnormal_ependyma_morphology1.05847220
68MP0001502_abnormal_circadian_rhythm1.05297370
69MP0000534_abnormal_ureter_morphology1.02484540
70MP0002876_abnormal_thyroid_physiology1.00307318
71MP0005503_abnormal_tendon_morphology0.98356350
72MP0005365_abnormal_bile_salt0.96748221
73MP0003633_abnormal_nervous_system0.95796518
74MP0004885_abnormal_endolymph0.95653012
75MP0001529_abnormal_vocalization0.92329343
76MP0003123_paternal_imprinting0.90043767
77MP0003121_genomic_imprinting0.88384345
78MP0010329_abnormal_lipoprotein_level0.87402038
79MP0000013_abnormal_adipose_tissue0.86764847
80MP0000920_abnormal_myelination0.86019757
81MP0004142_abnormal_muscle_tone0.84614603
82MP0003631_nervous_system_phenotype0.84073297
83* MP0002751_abnormal_autonomic_nervous0.83353419
84* MP0002752_abnormal_somatic_nervous0.83222768
85MP0004130_abnormal_muscle_cell0.82887940
86MP0001348_abnormal_lacrimal_gland0.82715083
87MP0010030_abnormal_orbit_morphology0.82109687
88MP0003172_abnormal_lysosome_physiology0.81451882
89MP0003861_abnormal_nervous_system0.80884466
90MP0002837_dystrophic_cardiac_calcinosis0.80750636
91MP0003385_abnormal_body_wall0.80649728
92MP0005551_abnormal_eye_electrophysiolog0.78299822
93MP0000639_abnormal_adrenal_gland0.77544313
94MP0001177_atelectasis0.77543188
95MP0005187_abnormal_penis_morphology0.76951097
96MP0002069_abnormal_eating/drinking_beha0.75984334
97MP0004742_abnormal_vestibular_system0.75113878
98MP0002638_abnormal_pupillary_reflex0.74613270
99MP0005499_abnormal_olfactory_system0.73568988
100MP0005394_taste/olfaction_phenotype0.73568988
101MP0002229_neurodegeneration0.72963454
102MP0003195_calcinosis0.72311026
103MP0004085_abnormal_heartbeat0.71975299
104MP0003634_abnormal_glial_cell0.71426262
105MP0000604_amyloidosis0.71127011
106MP0001666_abnormal_nutrient_absorption0.71106371
107MP0006072_abnormal_retinal_apoptosis0.70792410
108MP0008961_abnormal_basal_metabolism0.70604316
109MP0001963_abnormal_hearing_physiology0.70376179
110MP0000678_abnormal_parathyroid_gland0.69986872
111MP0003942_abnormal_urinary_system0.66933576
112MP0003632_abnormal_nervous_system0.64304830
113MP0001943_abnormal_respiration0.59825801
114MP0002089_abnormal_postnatal_growth/wei0.58870133
115MP0001986_abnormal_taste_sensitivity0.57403464
116MP0006292_abnormal_olfactory_placode0.56023239
117MP0000538_abnormal_urinary_bladder0.55621559
118MP0004233_abnormal_muscle_weight0.53607713
119MP0000026_abnormal_inner_ear0.53458723
120MP0003119_abnormal_digestive_system0.53015350
121MP0004133_heterotaxia0.52962833
122MP0002081_perinatal_lethality0.52677750
123MP0001485_abnormal_pinna_reflex0.51347532
124MP0002896_abnormal_bone_mineralization0.51019689

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.62546302
2Focal motor seizures (HP:0011153)5.41479580
3Focal seizures (HP:0007359)4.87935535
4Visual hallucinations (HP:0002367)4.01187561
5Atonic seizures (HP:0010819)3.67536531
6Febrile seizures (HP:0002373)3.64700458
7Epileptic encephalopathy (HP:0200134)3.56138605
8Neurofibrillary tangles (HP:0002185)3.49942264
9Action tremor (HP:0002345)3.45329603
10Ankle clonus (HP:0011448)3.33184653
11Progressive cerebellar ataxia (HP:0002073)3.31846445
12Supranuclear gaze palsy (HP:0000605)3.19778487
13Absence seizures (HP:0002121)3.10121546
14Deep venous thrombosis (HP:0002625)3.07533202
15Generalized tonic-clonic seizures (HP:0002069)3.04915938
16Amblyopia (HP:0000646)2.95573202
17Dialeptic seizures (HP:0011146)2.90298800
18Lymphangioma (HP:0100764)2.89400846
19Bronchomalacia (HP:0002780)2.83435028
20Complement deficiency (HP:0004431)2.76830411
21Broad-based gait (HP:0002136)2.72924480
22Abnormality of the aortic arch (HP:0012303)2.72459178
23Vitreoretinal degeneration (HP:0000655)2.65723363
24Depression (HP:0000716)2.60479369
25Hypoventilation (HP:0002791)2.60260248
26Turricephaly (HP:0000262)2.58320965
27Sleep apnea (HP:0010535)2.56301322
28Impaired vibration sensation in the lower limbs (HP:0002166)2.53712306
29Truncal ataxia (HP:0002078)2.53038748
30Insomnia (HP:0100785)2.52787445
31Termporal pattern (HP:0011008)2.52447869
32Insidious onset (HP:0003587)2.52447869
33Ulnar claw (HP:0001178)2.39129123
34Limb dystonia (HP:0002451)2.37922170
35Papilledema (HP:0001085)2.37065554
36Excessive salivation (HP:0003781)2.36750038
37Drooling (HP:0002307)2.36750038
38Urinary bladder sphincter dysfunction (HP:0002839)2.35477190
39Exotropia (HP:0000577)2.34732240
40Poor eye contact (HP:0000817)2.34192012
41Abnormality of aromatic amino acid family metabolism (HP:0004338)2.33892220
42Agitation (HP:0000713)2.33514308
43Abnormality of the lower motor neuron (HP:0002366)2.28126914
44Shallow orbits (HP:0000586)2.26243132
45Urinary urgency (HP:0000012)2.25326420
46Gaze-evoked nystagmus (HP:0000640)2.24515794
47Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24357865
48Polyphagia (HP:0002591)2.23175130
49Torticollis (HP:0000473)2.20573900
50Pointed chin (HP:0000307)2.20196982
51Diplopia (HP:0000651)2.19288322
52Abnormality of binocular vision (HP:0011514)2.19288322
53Epileptiform EEG discharges (HP:0011182)2.18747030
54Mutism (HP:0002300)2.18109632
55Hemiparesis (HP:0001269)2.16179340
56Abnormality of the ischium (HP:0003174)2.15859490
57Abnormal eating behavior (HP:0100738)2.15647364
58Hepatoblastoma (HP:0002884)2.15355916
59Anxiety (HP:0000739)2.13840625
60EEG with generalized epileptiform discharges (HP:0011198)2.11991876
61Pheochromocytoma (HP:0002666)2.11965054
62Spastic gait (HP:0002064)2.11369958
63Hyperventilation (HP:0002883)2.10739108
64Impaired social interactions (HP:0000735)2.08951085
65Abnormal social behavior (HP:0012433)2.08951085
66Alacrima (HP:0000522)2.08515681
67Neoplasm of the heart (HP:0100544)2.08128841
68Failure to thrive in infancy (HP:0001531)2.07285444
69Broad metatarsal (HP:0001783)2.07157723
70Cerebral aneurysm (HP:0004944)2.07050634
71Hypsarrhythmia (HP:0002521)2.06193771
72Dysdiadochokinesis (HP:0002075)2.05715868
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05482406
74Lower limb amyotrophy (HP:0007210)2.04844297
75Absent speech (HP:0001344)2.03636422
76Hyperlipoproteinemia (HP:0010980)2.03446748
77Narrow nasal bridge (HP:0000446)2.01862570
78Abnormality of pain sensation (HP:0010832)2.01821671
79Impaired pain sensation (HP:0007328)2.01821671
80Dysmetria (HP:0001310)2.00094797
81Peripheral hypomyelination (HP:0007182)1.99777462
82Impaired smooth pursuit (HP:0007772)1.98172490
83Hypoplastic ischia (HP:0003175)1.98083720
84Genetic anticipation (HP:0003743)1.94371230
85Visceral angiomatosis (HP:0100761)1.94351740
86Hypoplasia of the brainstem (HP:0002365)1.92976150
87Aplasia/Hypoplasia of the brainstem (HP:0007362)1.92976150
88Congenital malformation of the right heart (HP:0011723)1.90774719
89Double outlet right ventricle (HP:0001719)1.90774719
90Hypercortisolism (HP:0001578)1.90604963
91Postural instability (HP:0002172)1.90389100
92Lower limb muscle weakness (HP:0007340)1.89911821
93Megalencephaly (HP:0001355)1.87357095
94Bowel diverticulosis (HP:0005222)1.86824804
95Obstructive sleep apnea (HP:0002870)1.86202728
96Renal duplication (HP:0000075)1.84600372
97Stereotypic behavior (HP:0000733)1.84217410
98Anomalous pulmonary venous return (HP:0010772)1.84177635
99Abnormality of the corticospinal tract (HP:0002492)1.83487884
100Abnormality of complement system (HP:0005339)1.82799445
101Cerebral inclusion bodies (HP:0100314)1.82468458
102Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81368695
103Focal dystonia (HP:0004373)1.81172614
104Aplasia involving bones of the upper limbs (HP:0009823)1.81009439
105Aplasia of the phalanges of the hand (HP:0009802)1.81009439
106Aplasia involving bones of the extremities (HP:0009825)1.81009439
107Hammertoe (HP:0001765)1.79459969
108Hyperacusis (HP:0010780)1.79297152
109Truncus arteriosus (HP:0001660)1.79184511
110Elfin facies (HP:0004428)1.78986761
111Status epilepticus (HP:0002133)1.78379152
112Hypothermia (HP:0002045)1.78311190
113Akinesia (HP:0002304)1.78274562
114Intention tremor (HP:0002080)1.76699342
115Fetal akinesia sequence (HP:0001989)1.76621361
116Macroorchidism (HP:0000053)1.75906677
117Hyperthyroidism (HP:0000836)1.75560920
118Buphthalmos (HP:0000557)1.75309237
119Protruding tongue (HP:0010808)1.75150136
120Nuclear cataract (HP:0100018)1.74944867
121Abnormality of ocular smooth pursuit (HP:0000617)1.73169013
122Cutaneous finger syndactyly (HP:0010554)1.73020484
123Neuroendocrine neoplasm (HP:0100634)1.72833809
124Bradykinesia (HP:0002067)1.71279887
125Delayed CNS myelination (HP:0002188)1.70825965
126Bradycardia (HP:0001662)1.70678779
127Flat cornea (HP:0007720)1.69995833
128Lower limb asymmetry (HP:0100559)1.69677596
129Bladder diverticulum (HP:0000015)1.68947693
130Craniofacial dystonia (HP:0012179)1.68406629
131Hemangiomatosis (HP:0007461)1.68396769
132Abnormality of calcium-phosphate metabolism (HP:0100530)1.67983163
133Upper limb amyotrophy (HP:0009129)1.67981960
134Distal upper limb amyotrophy (HP:0007149)1.67981960
135Prolonged partial thromboplastin time (HP:0003645)1.67223398
136Specific learning disability (HP:0001328)1.66166133
137Aqueductal stenosis (HP:0002410)1.65877643
138Joint hemorrhage (HP:0005261)1.65344896
139Thickened helices (HP:0000391)1.65267508
140Renovascular hypertension (HP:0100817)1.64782912
141Xanthomatosis (HP:0000991)1.63123926
142Partial duplication of thumb phalanx (HP:0009944)1.62685305
143Hemiplegia (HP:0002301)1.62103731
144Prolonged QT interval (HP:0001657)1.62037292
145Cutaneous syndactyly (HP:0012725)1.61818340
146Systemic lupus erythematosus (HP:0002725)1.60748075
147Abnormality of the diencephalon (HP:0010662)1.59278288
148Annular pancreas (HP:0001734)1.59232314
149Rib fusion (HP:0000902)1.58954965
150Glomerulonephritis (HP:0000099)1.58938656
151Severe Myopia (HP:0011003)1.58869254
152Abnormality of the pulmonary veins (HP:0011718)1.56349446
153Tracheomalacia (HP:0002779)1.56114888
154Mixed hearing impairment (HP:0000410)1.55128061
155Hand muscle atrophy (HP:0009130)1.54622511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* NTRK34.52443162
2MAP3K94.02917539
3EPHA43.63471818
4MARK13.40210948
5TNIK3.19275598
6MAP3K42.84354900
7MINK12.69386807
8RIPK12.52028351
9NTRK12.48986463
10MAP2K72.38247692
11PRKD32.25383609
12DAPK22.17257939
13PAK62.16232171
14KSR22.00915607
15MAPK131.96550302
16FGFR21.90924238
17CASK1.86452035
18LATS21.74648686
19MAP2K41.70056122
20TRIB31.67815622
21NTRK21.66545389
22MAP3K121.62536656
23PRPF4B1.60354343
24KSR11.52201163
25SIK11.46778114
26MAPK151.46663273
27CAMKK11.44410498
28CDK51.44024149
29UHMK11.43898544
30MAP3K21.43200572
31FGFR41.41262890
32PNCK1.38928452
33GRK51.38421135
34TIE11.32422380
35PLK21.27770201
36PHKG11.20547457
37PHKG21.20547457
38STK381.19205462
39DAPK11.17993876
40SIK21.15955093
41RET1.13741634
42DDR21.13133839
43PRKCG1.10572077
44PAK31.08574970
45TYRO31.04038659
46PDGFRA1.03105103
47PINK11.02786112
48PKN10.98889839
49SCYL20.98856726
50DYRK1B0.95115877
51MAP3K70.94258581
52CDC42BPA0.92033748
53FER0.90902315
54CDK140.89518982
55PKN20.88276870
56CAMK2A0.87819891
57CDK180.86528736
58RIPK40.86200591
59CAMKK20.85262817
60LMTK20.84856591
61CDK150.84797708
62CSNK1G20.81802993
63PRKCH0.81437549
64LIMK10.80160251
65MAP3K60.79705558
66SGK2230.75718702
67SGK4940.75718702
68MARK20.74771952
69TAOK10.73703449
70CAMK1D0.72377485
71CDK11A0.72369913
72RPS6KA20.71670841
73PRKAA10.70911840
74MAP2K60.70885694
75MAP3K10.70401979
76EPHA30.67712377
77CAMK10.64336682
78WNK10.64054627
79CAMK1G0.63474131
80MAP3K110.63343332
81PRKCE0.63140650
82ARAF0.63061571
83STK110.62764492
84EPHB20.62470910
85CAMK2B0.61851683
86MAPK120.61443641
87ALK0.60480227
88MAP2K10.60446286
89EEF2K0.60329334
90PTK2B0.59098792
91SGK10.57798310
92DYRK1A0.56818457
93CAMK2G0.55706613
94SGK20.55696977
95MTOR0.55401584
96FES0.54270661
97FGFR30.54120031
98WNK30.53779509
99DYRK20.51236611
100DMPK0.49555533
101PRKCZ0.49419720
102PRKD10.48578716
103PDGFRB0.47922791
104ERBB30.46881049
105ADRBK10.46243597
106PTK20.44833863
107RPS6KA30.43493815
108ROCK20.41964017
109SGK30.41516131
110SRC0.41503239
111ICK0.41432727
112BMX0.40808422
113MAPK40.40545303
114INSRR0.40413840
115MAPK100.39331196
116CAMK40.38811117
117CAMK2D0.38703060
118CSNK1E0.38357715
119FYN0.36933090
120PRKD20.35759865
121ROCK10.35496488
122HIPK20.35406913
123DAPK30.34958854
124PRKCB0.34334427
125TNK20.31752210
126MAPK80.30819089
127WNK40.30486302
128CSNK1G30.30061848
129ERBB20.29798267
130CSNK1A1L0.29723109

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.25835936
2Synaptic vesicle cycle_Homo sapiens_hsa047212.96988011
3Circadian entrainment_Homo sapiens_hsa047132.48589242
4Long-term potentiation_Homo sapiens_hsa047202.45201768
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36173671
6Amphetamine addiction_Homo sapiens_hsa050312.36146445
7Glutamatergic synapse_Homo sapiens_hsa047242.34662540
8GABAergic synapse_Homo sapiens_hsa047272.31461637
9Olfactory transduction_Homo sapiens_hsa047402.30387720
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22394890
11Dopaminergic synapse_Homo sapiens_hsa047282.19483973
12Morphine addiction_Homo sapiens_hsa050322.18014684
13Insulin secretion_Homo sapiens_hsa049112.15550028
14Cholinergic synapse_Homo sapiens_hsa047251.98824801
15Taste transduction_Homo sapiens_hsa047421.90284070
16Cocaine addiction_Homo sapiens_hsa050301.90109057
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.84473906
18Salivary secretion_Homo sapiens_hsa049701.73624369
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72143949
20Bile secretion_Homo sapiens_hsa049761.67088887
21Serotonergic synapse_Homo sapiens_hsa047261.65841580
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65307456
23Renin secretion_Homo sapiens_hsa049241.60027424
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59242519
25Complement and coagulation cascades_Homo sapiens_hsa046101.58084545
26Oxytocin signaling pathway_Homo sapiens_hsa049211.57984472
27Long-term depression_Homo sapiens_hsa047301.56324555
28Gastric acid secretion_Homo sapiens_hsa049711.55532321
29GnRH signaling pathway_Homo sapiens_hsa049121.53660693
30Axon guidance_Homo sapiens_hsa043601.48125131
31Gap junction_Homo sapiens_hsa045401.46048992
32Type II diabetes mellitus_Homo sapiens_hsa049301.45916832
33Calcium signaling pathway_Homo sapiens_hsa040201.44201127
34Arginine biosynthesis_Homo sapiens_hsa002201.42223091
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36922879
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33140532
37Notch signaling pathway_Homo sapiens_hsa043301.32475266
38Vitamin B6 metabolism_Homo sapiens_hsa007501.28180335
39Histidine metabolism_Homo sapiens_hsa003401.28020601
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27441837
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27107896
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24440498
43Melanogenesis_Homo sapiens_hsa049161.24007010
44* Estrogen signaling pathway_Homo sapiens_hsa049151.21699053
45* Glioma_Homo sapiens_hsa052141.17103095
46cAMP signaling pathway_Homo sapiens_hsa040241.15199557
47Dorso-ventral axis formation_Homo sapiens_hsa043201.13207733
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.12969788
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07059538
50Collecting duct acid secretion_Homo sapiens_hsa049661.05265958
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03515140
52* ErbB signaling pathway_Homo sapiens_hsa040121.02305782
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01370344
54Phenylalanine metabolism_Homo sapiens_hsa003601.00841083
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00267007
56PPAR signaling pathway_Homo sapiens_hsa033200.97812288
57Dilated cardiomyopathy_Homo sapiens_hsa054140.96727560
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.96441026
59Vibrio cholerae infection_Homo sapiens_hsa051100.96425904
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.93892912
61Oocyte meiosis_Homo sapiens_hsa041140.93536358
62Butanoate metabolism_Homo sapiens_hsa006500.91103570
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89493095
64Endometrial cancer_Homo sapiens_hsa052130.86447367
65Cardiac muscle contraction_Homo sapiens_hsa042600.86293299
66* Phospholipase D signaling pathway_Homo sapiens_hsa040720.85429378
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84027831
68MAPK signaling pathway_Homo sapiens_hsa040100.83918103
69Arginine and proline metabolism_Homo sapiens_hsa003300.83609765
70Retinol metabolism_Homo sapiens_hsa008300.82552301
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82186035
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.81536164
73Caffeine metabolism_Homo sapiens_hsa002320.80404094
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80337771
75* Neurotrophin signaling pathway_Homo sapiens_hsa047220.78792765
76Wnt signaling pathway_Homo sapiens_hsa043100.78639687
77Thyroid hormone synthesis_Homo sapiens_hsa049180.77827601
78Fat digestion and absorption_Homo sapiens_hsa049750.76634379
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76633494
80AMPK signaling pathway_Homo sapiens_hsa041520.75224520
81Hedgehog signaling pathway_Homo sapiens_hsa043400.74177805
82Pancreatic secretion_Homo sapiens_hsa049720.73812628
83ABC transporters_Homo sapiens_hsa020100.73326047
84Choline metabolism in cancer_Homo sapiens_hsa052310.72965473
85Fatty acid degradation_Homo sapiens_hsa000710.71040239
86mTOR signaling pathway_Homo sapiens_hsa041500.70160409
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69991111
88Tyrosine metabolism_Homo sapiens_hsa003500.68902122
89Phototransduction_Homo sapiens_hsa047440.68822960
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68232638
91Protein digestion and absorption_Homo sapiens_hsa049740.66545239
92* Alcoholism_Homo sapiens_hsa050340.66057327
93Rap1 signaling pathway_Homo sapiens_hsa040150.65219995
94Linoleic acid metabolism_Homo sapiens_hsa005910.65028417
95beta-Alanine metabolism_Homo sapiens_hsa004100.64701629
96* Ras signaling pathway_Homo sapiens_hsa040140.64618287
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62814476
98Glucagon signaling pathway_Homo sapiens_hsa049220.62291268
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62001206
100Type I diabetes mellitus_Homo sapiens_hsa049400.60223978
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60167807
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59889469
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59500262
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59428489
105Lysine degradation_Homo sapiens_hsa003100.59176184
106Prion diseases_Homo sapiens_hsa050200.58842041
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57478105
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57111309
109Chemical carcinogenesis_Homo sapiens_hsa052040.56124352
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56009259
111Glycerolipid metabolism_Homo sapiens_hsa005610.55795999
112ECM-receptor interaction_Homo sapiens_hsa045120.55793572
113* VEGF signaling pathway_Homo sapiens_hsa043700.55565840
114Colorectal cancer_Homo sapiens_hsa052100.55033556
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54917712
116* Insulin signaling pathway_Homo sapiens_hsa049100.53883466
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53812019
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53419335
119Renal cell carcinoma_Homo sapiens_hsa052110.52076399
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51700284
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.51301550
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51273268
123Hippo signaling pathway_Homo sapiens_hsa043900.50920462
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.50909877
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49348989
126Endocytosis_Homo sapiens_hsa041440.49099004
127Basal cell carcinoma_Homo sapiens_hsa052170.48952477
128Thyroid cancer_Homo sapiens_hsa052160.48881872
129Circadian rhythm_Homo sapiens_hsa047100.47810825
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47277861
131Non-small cell lung cancer_Homo sapiens_hsa052230.46623514
132Melanoma_Homo sapiens_hsa052180.45412397
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41362407
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.40161271
135Inositol phosphate metabolism_Homo sapiens_hsa005620.40140150
136Ovarian steroidogenesis_Homo sapiens_hsa049130.36946754
137Tight junction_Homo sapiens_hsa045300.35441852
138* Focal adhesion_Homo sapiens_hsa045100.35065514
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33765134

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