SHC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.30883184
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.28844021
3synaptic vesicle maturation (GO:0016188)6.24395653
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.98805332
5vocalization behavior (GO:0071625)5.73244471
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52242003
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.34266105
8synaptic vesicle exocytosis (GO:0016079)5.16887023
9dendritic spine morphogenesis (GO:0060997)5.14542285
10glutamate secretion (GO:0014047)5.11682585
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.06714580
12neuronal action potential propagation (GO:0019227)5.05569463
13regulation of glutamate receptor signaling pathway (GO:1900449)5.01990549
14regulation of synaptic vesicle exocytosis (GO:2000300)4.92842304
15regulation of synapse structural plasticity (GO:0051823)4.89303661
16layer formation in cerebral cortex (GO:0021819)4.88095447
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.85822231
18protein localization to synapse (GO:0035418)4.76966448
19exploration behavior (GO:0035640)4.72836687
20regulation of neuronal synaptic plasticity (GO:0048168)4.70475334
21neuron cell-cell adhesion (GO:0007158)4.67400494
22presynaptic membrane assembly (GO:0097105)4.63359980
23neurotransmitter-gated ion channel clustering (GO:0072578)4.57768137
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.46163783
25neurotransmitter secretion (GO:0007269)4.39842582
26presynaptic membrane organization (GO:0097090)4.39526450
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.34077145
28regulation of synaptic vesicle transport (GO:1902803)4.33460589
29gamma-aminobutyric acid transport (GO:0015812)4.18981878
30axon ensheathment in central nervous system (GO:0032291)4.15517360
31central nervous system myelination (GO:0022010)4.15517360
32amino acid import (GO:0043090)4.13601798
33proline transport (GO:0015824)4.03298792
34axonal fasciculation (GO:0007413)3.98514411
35* synaptic transmission, glutamatergic (GO:0035249)3.93728421
36cerebellar granule cell differentiation (GO:0021707)3.92650722
37glutamate receptor signaling pathway (GO:0007215)3.92365882
38positive regulation of membrane potential (GO:0045838)3.91456237
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.89874537
40long-term memory (GO:0007616)3.86775474
41auditory behavior (GO:0031223)3.85477421
42positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.82983397
43regulation of dendritic spine morphogenesis (GO:0061001)3.80434948
44neuron recognition (GO:0008038)3.80003296
45neuromuscular process controlling balance (GO:0050885)3.79913348
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.74296906
47sodium ion export (GO:0071436)3.74000193
48neuronal ion channel clustering (GO:0045161)3.71732125
49* neuron-neuron synaptic transmission (GO:0007270)3.70076842
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.69736974
51cellular potassium ion homeostasis (GO:0030007)3.65834214
52activation of protein kinase A activity (GO:0034199)3.65815587
53response to auditory stimulus (GO:0010996)3.65169664
54prepulse inhibition (GO:0060134)3.63709389
55regulation of synaptic plasticity (GO:0048167)3.60242110
56innervation (GO:0060384)3.58300141
57potassium ion homeostasis (GO:0055075)3.55461818
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55318832
59dendrite morphogenesis (GO:0048813)3.52802613
60postsynaptic membrane organization (GO:0001941)3.51807824
61regulation of postsynaptic membrane potential (GO:0060078)3.51664769
62negative regulation of dendrite morphogenesis (GO:0050774)3.49914004
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.48254785
64dendritic spine organization (GO:0097061)3.47113121
65neurotransmitter transport (GO:0006836)3.45943013
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.45885268
67potassium ion import (GO:0010107)3.42217473
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.40976947
69positive regulation of synapse maturation (GO:0090129)3.40122854
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.38798219
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.36509696
72positive regulation of dendritic spine morphogenesis (GO:0061003)3.35940182
73transmission of nerve impulse (GO:0019226)3.33487656
74L-amino acid import (GO:0043092)3.31770178
75establishment of mitochondrion localization (GO:0051654)3.29258022
76cellular sodium ion homeostasis (GO:0006883)3.27436191
77regulation of neurotransmitter secretion (GO:0046928)3.25488206
78synaptic vesicle endocytosis (GO:0048488)3.25278037
79positive regulation of neurotransmitter secretion (GO:0001956)3.25172645
80regulation of neurotransmitter levels (GO:0001505)3.23285663
81positive regulation of neurotransmitter transport (GO:0051590)3.22796564
82regulation of ARF protein signal transduction (GO:0032012)3.22108260
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21431481
84cell communication by electrical coupling (GO:0010644)3.21266028
85glycine transport (GO:0015816)3.21093491
86regulation of voltage-gated calcium channel activity (GO:1901385)3.19205215
87long-term synaptic potentiation (GO:0060291)3.18944329
88synapse assembly (GO:0007416)3.16658768
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.15997316
90regulation of dendritic spine development (GO:0060998)3.14821838
91membrane depolarization during action potential (GO:0086010)3.10324086
92vesicle transport along microtubule (GO:0047496)3.08697964
93regulation of neurotransmitter transport (GO:0051588)3.07811889
94pyrimidine nucleobase catabolic process (GO:0006208)3.06011882
95acidic amino acid transport (GO:0015800)3.06008127
96positive regulation of dendritic spine development (GO:0060999)3.05300706
97membrane hyperpolarization (GO:0060081)3.05029472
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04856110
99neuromuscular synaptic transmission (GO:0007274)3.04273995
100social behavior (GO:0035176)3.04030662
101intraspecies interaction between organisms (GO:0051703)3.04030662
102learning (GO:0007612)3.03785938
103establishment of nucleus localization (GO:0040023)3.03330730
104neuromuscular process (GO:0050905)3.02059729
105mechanosensory behavior (GO:0007638)3.01839138
106membrane depolarization (GO:0051899)3.00800916
107regulation of vesicle fusion (GO:0031338)3.00559247
108negative regulation of cytosolic calcium ion concentration (GO:0051481)3.00423176
109positive regulation of synapse assembly (GO:0051965)3.00270567
110cerebellar Purkinje cell differentiation (GO:0021702)3.00087786
111neurotransmitter uptake (GO:0001504)2.97337361
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96970341
113central nervous system projection neuron axonogenesis (GO:0021952)2.95618170
114G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94832640
115positive regulation of synaptic transmission (GO:0050806)2.94684848
116startle response (GO:0001964)2.94293489
117cell migration in hindbrain (GO:0021535)2.93850966
118adult walking behavior (GO:0007628)2.91176414
119behavioral fear response (GO:0001662)2.90980828
120behavioral defense response (GO:0002209)2.90980828
121negative regulation of dendrite development (GO:2000171)2.90921787
122synapse organization (GO:0050808)2.90415779
123regulation of synaptic transmission (GO:0050804)2.89379141
124membrane assembly (GO:0071709)2.85168023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.85164517
2GBX2_23144817_ChIP-Seq_PC3_Human3.34239968
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08701581
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07194289
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04885089
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.78438761
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76236784
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76236784
9* DROSHA_22980978_ChIP-Seq_HELA_Human2.70567595
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.67118825
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63070865
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54496233
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.54202666
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53802316
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50577072
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45860791
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38069761
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.33583785
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28482641
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27141082
21* EED_16625203_ChIP-ChIP_MESCs_Mouse2.27008023
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.24270065
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.22153463
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.20317351
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16458878
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15160721
27AR_21572438_ChIP-Seq_LNCaP_Human1.97498285
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.90008532
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83019742
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76358974
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68805271
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66940772
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65503162
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53537892
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.49263093
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45738280
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.43397051
38RNF2_27304074_Chip-Seq_NSC_Mouse1.42012471
39SOX2_21211035_ChIP-Seq_LN229_Gbm1.36916044
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34415440
41RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34180565
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32524860
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31844608
44* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31593278
45* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31514200
46KDM2B_26808549_Chip-Seq_K562_Human1.30167690
47TAF15_26573619_Chip-Seq_HEK293_Human1.29362888
48AR_19668381_ChIP-Seq_PC3_Human1.28977289
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28913427
50* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27482133
51* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25948033
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.23613900
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23451731
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23284995
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22965871
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22788391
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22515584
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22310118
59* STAT3_23295773_ChIP-Seq_U87_Human1.22000825
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.20933027
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20932289
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.20873662
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19975027
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.19744489
65YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18521410
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.16599936
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16005162
68ZNF274_21170338_ChIP-Seq_K562_Hela1.14826857
69AR_25329375_ChIP-Seq_VCAP_Human1.14630896
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13117388
71* P300_19829295_ChIP-Seq_ESCs_Human1.12621254
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.12541141
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11287114
74IGF1R_20145208_ChIP-Seq_DFB_Human1.11155428
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09247742
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07401458
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06952753
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06105109
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.05434709
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.05072835
81TP53_16413492_ChIP-PET_HCT116_Human1.04702597
82AHR_22903824_ChIP-Seq_MCF-7_Human1.04421694
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04179254
84TCF4_23295773_ChIP-Seq_U87_Human1.03624664
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03620307
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02799725
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02778419
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02511553
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02283895
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.01168511
91SMAD3_21741376_ChIP-Seq_ESCs_Human1.00781712
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00627798
93* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00472903
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00320496
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00320496
96* SOX9_26525672_Chip-Seq_HEART_Mouse0.99929668
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99366931
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99070714
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98142644
100EP300_21415370_ChIP-Seq_HL-1_Mouse0.97792906
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96722449
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.95680103
103* TP53_20018659_ChIP-ChIP_R1E_Mouse0.95642792
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94002154
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92994513
106* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92569344
107CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92207861
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91774458
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91602863
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91266164
111RXR_22108803_ChIP-Seq_LS180_Human0.91044505
112KDM2B_26808549_Chip-Seq_REH_Human0.90517360
113RUNX2_22187159_ChIP-Seq_PCA_Human0.90210943
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88377662
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.87049055
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.86117103
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85665539
118* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83756733
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83181169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.11953571
2MP0003880_abnormal_central_pattern4.49304389
3MP0003635_abnormal_synaptic_transmissio4.29375271
4MP0004270_analgesia3.97258228
5MP0002063_abnormal_learning/memory/cond3.47758433
6MP0009745_abnormal_behavioral_response3.39806517
7MP0002822_catalepsy3.30517896
8MP0005423_abnormal_somatic_nervous3.14802054
9MP0002064_seizures3.09610425
10MP0009046_muscle_twitch2.90617933
11MP0001968_abnormal_touch/_nociception2.77779666
12MP0002572_abnormal_emotion/affect_behav2.74481542
13MP0001486_abnormal_startle_reflex2.69455918
14MP0002734_abnormal_mechanical_nocicepti2.62438582
15MP0002272_abnormal_nervous_system2.39192575
16MP0009780_abnormal_chondrocyte_physiolo2.19924738
17MP0004858_abnormal_nervous_system2.18499494
18MP0000778_abnormal_nervous_system2.07327771
19MP0001501_abnormal_sleep_pattern1.99477357
20MP0008569_lethality_at_weaning1.93016208
21MP0003329_amyloid_beta_deposits1.91375281
22MP0002909_abnormal_adrenal_gland1.91016761
23MP0004811_abnormal_neuron_physiology1.88305231
24MP0002736_abnormal_nociception_after1.87450025
25MP0002733_abnormal_thermal_nociception1.85433028
26MP0002067_abnormal_sensory_capabilities1.83992349
27MP0002184_abnormal_innervation1.82266126
28MP0002735_abnormal_chemical_nociception1.81114745
29MP0002557_abnormal_social/conspecific_i1.81112438
30MP0001970_abnormal_pain_threshold1.79488853
31MP0001440_abnormal_grooming_behavior1.78968593
32MP0004885_abnormal_endolymph1.73904981
33MP0003879_abnormal_hair_cell1.73802538
34MP0004924_abnormal_behavior1.72860386
35MP0005386_behavior/neurological_phenoty1.72860386
36MP0005646_abnormal_pituitary_gland1.72270927
37MP0000955_abnormal_spinal_cord1.71443424
38MP0000569_abnormal_digit_pigmentation1.52206209
39MP0002882_abnormal_neuron_morphology1.46851598
40MP0002066_abnormal_motor_capabilities/c1.42594347
41MP0003633_abnormal_nervous_system1.40745832
42MP0001984_abnormal_olfaction1.32306095
43MP0002152_abnormal_brain_morphology1.23261557
44MP0003631_nervous_system_phenotype1.16631117
45MP0003283_abnormal_digestive_organ1.15651916
46MP0005645_abnormal_hypothalamus_physiol1.15490078
47MP0003787_abnormal_imprinting1.14826755
48MP0001529_abnormal_vocalization1.14649242
49MP0001502_abnormal_circadian_rhythm1.12195540
50MP0003634_abnormal_glial_cell1.09161594
51MP0004142_abnormal_muscle_tone1.06802591
52MP0001177_atelectasis1.04280442
53MP0003123_paternal_imprinting1.02344102
54MP0001905_abnormal_dopamine_level1.00226093
55MP0003121_genomic_imprinting0.97538360
56MP0003690_abnormal_glial_cell0.97146682
57MP0000751_myopathy0.96176857
58MP0000631_abnormal_neuroendocrine_gland0.95907690
59MP0003075_altered_response_to0.95528946
60MP0006276_abnormal_autonomic_nervous0.94817771
61MP0001299_abnormal_eye_distance/0.94553575
62MP0004742_abnormal_vestibular_system0.93017344
63MP0000566_synostosis0.92663328
64MP0008872_abnormal_physiological_respon0.90500659
65MP0008961_abnormal_basal_metabolism0.89750471
66MP0002069_abnormal_eating/drinking_beha0.88483686
67MP0002638_abnormal_pupillary_reflex0.88231607
68MP0008874_decreased_physiological_sensi0.87000126
69MP0002229_neurodegeneration0.85855627
70MP0004233_abnormal_muscle_weight0.85552310
71MP0003137_abnormal_impulse_conducting0.85215775
72MP0000026_abnormal_inner_ear0.84691799
73MP0001188_hyperpigmentation0.84142465
74MP0001485_abnormal_pinna_reflex0.83594167
75MP0003632_abnormal_nervous_system0.83443623
76MP0004085_abnormal_heartbeat0.81085982
77MP0002090_abnormal_vision0.78531082
78MP0001963_abnormal_hearing_physiology0.77950297
79MP0000604_amyloidosis0.77063299
80MP0010386_abnormal_urinary_bladder0.76720646
81MP0000579_abnormal_nail_morphology0.76269743
82MP0000920_abnormal_myelination0.76221755
83MP0003938_abnormal_ear_development0.75571172
84MP0004147_increased_porphyrin_level0.73325869
85MP0005499_abnormal_olfactory_system0.73158922
86MP0005394_taste/olfaction_phenotype0.73158922
87MP0003861_abnormal_nervous_system0.72936251
88MP0005167_abnormal_blood-brain_barrier0.72649829
89MP0003122_maternal_imprinting0.72305303
90MP0009379_abnormal_foot_pigmentation0.71397145
91MP0004145_abnormal_muscle_electrophysio0.70805051
92MP0005623_abnormal_meninges_morphology0.70417088
93MP0006292_abnormal_olfactory_placode0.69838183
94MP0002752_abnormal_somatic_nervous0.69720234
95MP0003172_abnormal_lysosome_physiology0.68085840
96MP0004215_abnormal_myocardial_fiber0.67937411
97MP0005551_abnormal_eye_electrophysiolog0.67468007
98MP0002249_abnormal_larynx_morphology0.66078420
99MP0000534_abnormal_ureter_morphology0.65347542
100MP0005409_darkened_coat_color0.65104075
101MP0001346_abnormal_lacrimal_gland0.64410229
102MP0001958_emphysema0.63322814
103MP0004484_altered_response_of0.63064780
104MP0010234_abnormal_vibrissa_follicle0.59810170
105MP0005535_abnormal_body_temperature0.59591161
106MP0002653_abnormal_ependyma_morphology0.58841494
107MP0010769_abnormal_survival0.58221589
108MP0002081_perinatal_lethality0.57941656
109MP0004133_heterotaxia0.57783776
110MP0001943_abnormal_respiration0.57518353
111MP0000013_abnormal_adipose_tissue0.56616593
112MP0002089_abnormal_postnatal_growth/wei0.56298836
113MP0000049_abnormal_middle_ear0.56135705
114MP0002082_postnatal_lethality0.55623729
115MP0010770_preweaning_lethality0.55623729
116MP0004510_myositis0.55447773
117MP0010768_mortality/aging0.53992633
118MP0005187_abnormal_penis_morphology0.53004263
119MP0001986_abnormal_taste_sensitivity0.52411209
120MP0004130_abnormal_muscle_cell0.50709693

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.28699187
2Focal motor seizures (HP:0011153)6.75889903
3Focal seizures (HP:0007359)5.39704195
4Visual hallucinations (HP:0002367)4.43598322
5Epileptic encephalopathy (HP:0200134)4.29125564
6Action tremor (HP:0002345)3.87684386
7Progressive cerebellar ataxia (HP:0002073)3.78021690
8Ankle clonus (HP:0011448)3.74432212
9Febrile seizures (HP:0002373)3.67902002
10Papilledema (HP:0001085)3.60765155
11Impaired vibration sensation in the lower limbs (HP:0002166)3.56305016
12Poor eye contact (HP:0000817)3.48446613
13Absence seizures (HP:0002121)3.47955188
14Supranuclear gaze palsy (HP:0000605)3.44199887
15Generalized tonic-clonic seizures (HP:0002069)3.41782198
16Broad-based gait (HP:0002136)3.41072454
17Atonic seizures (HP:0010819)3.39234978
18Urinary bladder sphincter dysfunction (HP:0002839)3.34750184
19Impaired social interactions (HP:0000735)3.21932684
20Abnormal social behavior (HP:0012433)3.21932684
21Depression (HP:0000716)3.19190950
22Megalencephaly (HP:0001355)3.16550288
23Mutism (HP:0002300)3.12543186
24Dialeptic seizures (HP:0011146)3.11401816
25Dysdiadochokinesis (HP:0002075)3.06137109
26Postural instability (HP:0002172)2.95518680
27Gaze-evoked nystagmus (HP:0000640)2.95206807
28Abnormal eating behavior (HP:0100738)2.87842292
29Torticollis (HP:0000473)2.86023167
30Truncal ataxia (HP:0002078)2.85798257
31Urinary urgency (HP:0000012)2.83847742
32Genetic anticipation (HP:0003743)2.81980417
33Anxiety (HP:0000739)2.75986575
34Dysmetria (HP:0001310)2.75228006
35Hyperventilation (HP:0002883)2.68199686
36Neurofibrillary tangles (HP:0002185)2.65906019
37Stereotypic behavior (HP:0000733)2.64046634
38Spastic gait (HP:0002064)2.58713499
39Impaired smooth pursuit (HP:0007772)2.58148304
40Intention tremor (HP:0002080)2.55321315
41Amblyopia (HP:0000646)2.55214322
42Drooling (HP:0002307)2.55112350
43Excessive salivation (HP:0003781)2.55112350
44Akinesia (HP:0002304)2.54490576
45Scanning speech (HP:0002168)2.54366418
46Ankyloglossia (HP:0010296)2.51946228
47Impaired vibratory sensation (HP:0002495)2.51424083
48Hemiparesis (HP:0001269)2.51311867
49Focal dystonia (HP:0004373)2.51170809
50Hemiplegia (HP:0002301)2.51058398
51Abnormality of the lower motor neuron (HP:0002366)2.48331882
52Cerebral inclusion bodies (HP:0100314)2.46706831
53Pointed chin (HP:0000307)2.45471957
54Sleep apnea (HP:0010535)2.39577574
55Lower limb muscle weakness (HP:0007340)2.36258906
56Obstructive sleep apnea (HP:0002870)2.34501765
57Fetal akinesia sequence (HP:0001989)2.33341011
58Bradykinesia (HP:0002067)2.33316014
59Split foot (HP:0001839)2.32810733
60Ventricular fibrillation (HP:0001663)2.32676571
61Epileptiform EEG discharges (HP:0011182)2.29495404
62Dysmetric saccades (HP:0000641)2.28030447
63Craniofacial dystonia (HP:0012179)2.26720672
64EEG with generalized epileptiform discharges (HP:0011198)2.25527512
65Annular pancreas (HP:0001734)2.24370264
66Amyotrophic lateral sclerosis (HP:0007354)2.22328086
67Termporal pattern (HP:0011008)2.22309774
68Insidious onset (HP:0003587)2.22309774
69Insomnia (HP:0100785)2.21805192
70Turricephaly (HP:0000262)2.20313647
71Abnormality of ocular smooth pursuit (HP:0000617)2.20287423
72Hypsarrhythmia (HP:0002521)2.19156423
73Aplasia involving bones of the extremities (HP:0009825)2.18966420
74Aplasia involving bones of the upper limbs (HP:0009823)2.18966420
75Aplasia of the phalanges of the hand (HP:0009802)2.18966420
76Abnormality of binocular vision (HP:0011514)2.18487762
77Diplopia (HP:0000651)2.18487762
78Lower limb amyotrophy (HP:0007210)2.16770785
79Bronchomalacia (HP:0002780)2.15535493
80Progressive inability to walk (HP:0002505)2.12757961
81Peripheral hypomyelination (HP:0007182)2.11287079
82Polyphagia (HP:0002591)2.07947792
83Clonus (HP:0002169)2.06015608
84Blue irides (HP:0000635)2.03668144
85Abnormality of the corticospinal tract (HP:0002492)2.03217895
86Aqueductal stenosis (HP:0002410)2.03141192
87Bundle branch block (HP:0011710)2.01248208
88Status epilepticus (HP:0002133)2.00672770
89Abnormal EKG (HP:0003115)1.98732810
90Absent speech (HP:0001344)1.97012709
91Tetraplegia (HP:0002445)1.95577074
92Inappropriate behavior (HP:0000719)1.95176968
93Resting tremor (HP:0002322)1.93563187
94Apathy (HP:0000741)1.92023248
95Morphological abnormality of the pyramidal tract (HP:0002062)1.90359528
96Delusions (HP:0000746)1.90061261
97Limb dystonia (HP:0002451)1.88983213
98Neuronal loss in central nervous system (HP:0002529)1.87940580
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.84747984
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.84747984
101Cerebral hypomyelination (HP:0006808)1.83949407
102Pheochromocytoma (HP:0002666)1.83440334
103Mild short stature (HP:0003502)1.83180653
104Generalized myoclonic seizures (HP:0002123)1.82922947
105Intellectual disability, profound (HP:0002187)1.78002062
106Spastic tetraparesis (HP:0001285)1.77800786
107Hypoplasia of the corpus callosum (HP:0002079)1.74718845
108Thickened helices (HP:0000391)1.74531803
109Inability to walk (HP:0002540)1.74194776
110Truncus arteriosus (HP:0001660)1.73973743
111Abnormality of oral frenula (HP:0000190)1.72230260
112Agitation (HP:0000713)1.71991715
113Incomplete penetrance (HP:0003829)1.71619045
114Gait ataxia (HP:0002066)1.71194867
115Autism (HP:0000717)1.68172730
116Cutaneous finger syndactyly (HP:0010554)1.67597037
117Abnormality of saccadic eye movements (HP:0000570)1.66601434
118Shallow orbits (HP:0000586)1.64644078
119Vertebral arch anomaly (HP:0008438)1.63987326
120Lower limb asymmetry (HP:0100559)1.59876870
121Hypoventilation (HP:0002791)1.57560508
122Coronal craniosynostosis (HP:0004440)1.57378515
123Tracheomalacia (HP:0002779)1.57168409
124Rigidity (HP:0002063)1.56760094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.66517405
2MARK14.19473095
3MAP3K94.11563634
4NTRK33.97761328
5KSR12.85359847
6MINK12.85068189
7MAP3K42.67116492
8DAPK22.65795523
9PAK62.57489259
10PRKD32.50025863
11KSR22.20668152
12CAMKK12.14288069
13MAP2K72.03829615
14* NTRK21.91581743
15CDK51.62959774
16RIPK41.55028504
17DAPK11.50404126
18TNIK1.49907130
19TAOK11.43740276
20MAP2K41.42514237
21SIK31.40719599
22STK381.38102479
23LATS21.35309665
24TYRO31.33561505
25MAPK131.31138508
26PHKG11.30360675
27PHKG21.30360675
28CASK1.29318740
29PRPF4B1.24438696
30SIK21.21455766
31PRKCG1.08441280
32MAP3K21.07583617
33STK111.07431898
34CDK181.01903050
35PLK20.99968795
36FES0.99266707
37UHMK10.99250901
38SGK2230.97906854
39SGK4940.97906854
40ALK0.96990171
41SGK20.93650670
42CDK150.92682448
43PKN10.92514502
44LMTK20.90254431
45RET0.88910672
46SGK30.87733507
47MAP3K120.87586124
48CAMKK20.86232290
49PAK30.85679423
50CDK140.84962410
51ARAF0.84739947
52GRK50.84301969
53PNCK0.83074780
54RAF10.81307847
55CAMK2A0.81265610
56MAP3K130.79879410
57CDK11A0.79093646
58CAMK10.78818344
59PRKCH0.78276224
60CAMK2G0.77729642
61ROCK20.75209361
62DYRK20.72577295
63CDK190.72363576
64NEK10.71665987
65SGK10.71298763
66CSNK1G20.71232787
67MUSK0.70590351
68BCR0.70414174
69MAPK120.69005896
70* NTRK10.68789510
71BRSK10.67905759
72RIPK10.67291211
73SCYL20.66488425
74EPHB20.66362171
75MARK20.63389511
76PRKCZ0.63170473
77LIMK10.62830559
78OXSR10.61124008
79PDK10.57977860
80RPS6KA30.57426429
81TRIB30.56526484
82ERBB20.55814601
83CAMK2D0.54290945
84DMPK0.53881366
85PINK10.53689089
86DYRK1A0.52985167
87PDPK10.51957055
88FYN0.49585670
89MAPK100.48591138
90CAMK2B0.47697001
91MAP3K70.47327112
92BMPR20.47148166
93FGFR20.46913057
94CAMK1G0.45624417
95MOS0.44687434
96ICK0.43680778
97CDC42BPA0.42076244
98NEK60.38416692
99WNK30.37926218
100MAP3K10.37126314
101WNK10.36870865
102PRKCE0.36599000
103CAMK40.35687189
104PRKG10.35652102
105ROCK10.35490413
106TAF10.34367965
107PTK20.33632181
108DAPK30.33453464
109PTK2B0.33146179
110PDGFRB0.33022925
111CCNB10.32657439
112STK390.32153523
113CSNK1D0.31399136
114AKT30.31286628
115DDR20.31263265
116PDGFRA0.30359980
117RPS6KA20.29867748
118CSNK1E0.29262721
119RPS6KB10.28493796
120BRAF0.28444610
121GSK3B0.26373462
122PRKACA0.26359012
123MAPK80.25925011

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.28063775
2Synaptic vesicle cycle_Homo sapiens_hsa047212.92306793
3Olfactory transduction_Homo sapiens_hsa047402.89166655
4Circadian entrainment_Homo sapiens_hsa047132.67995050
5GABAergic synapse_Homo sapiens_hsa047272.60232738
6Glutamatergic synapse_Homo sapiens_hsa047242.53167140
7Long-term potentiation_Homo sapiens_hsa047202.48546198
8Morphine addiction_Homo sapiens_hsa050322.45135999
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38129084
10Amphetamine addiction_Homo sapiens_hsa050312.28244063
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21918627
12Salivary secretion_Homo sapiens_hsa049702.16865193
13Dopaminergic synapse_Homo sapiens_hsa047282.07627760
14Cholinergic synapse_Homo sapiens_hsa047251.96680024
15Nitrogen metabolism_Homo sapiens_hsa009101.95042209
16Insulin secretion_Homo sapiens_hsa049111.92851312
17Gastric acid secretion_Homo sapiens_hsa049711.87052838
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85099899
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69982457
20Cocaine addiction_Homo sapiens_hsa050301.69697837
21Oxytocin signaling pathway_Homo sapiens_hsa049211.64255705
22Renin secretion_Homo sapiens_hsa049241.57490288
23Long-term depression_Homo sapiens_hsa047301.53337575
24Calcium signaling pathway_Homo sapiens_hsa040201.52183445
25GnRH signaling pathway_Homo sapiens_hsa049121.48795795
26Gap junction_Homo sapiens_hsa045401.46968189
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46575628
28Taste transduction_Homo sapiens_hsa047421.43631845
29Serotonergic synapse_Homo sapiens_hsa047261.39400348
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37343102
31Vitamin B6 metabolism_Homo sapiens_hsa007501.31893695
32Axon guidance_Homo sapiens_hsa043601.31630048
33cAMP signaling pathway_Homo sapiens_hsa040241.30177315
34Type II diabetes mellitus_Homo sapiens_hsa049301.29726330
35* Glioma_Homo sapiens_hsa052141.28039215
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24392379
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23297741
38* Estrogen signaling pathway_Homo sapiens_hsa049151.20543655
39Dorso-ventral axis formation_Homo sapiens_hsa043201.17504655
40Melanogenesis_Homo sapiens_hsa049161.13662274
41* ErbB signaling pathway_Homo sapiens_hsa040121.12904341
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10384559
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07286932
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04145770
45Oocyte meiosis_Homo sapiens_hsa041141.01580651
46* Phospholipase D signaling pathway_Homo sapiens_hsa040720.94758411
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90246988
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87842993
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.87224348
50Endometrial cancer_Homo sapiens_hsa052130.83516880
51Dilated cardiomyopathy_Homo sapiens_hsa054140.79614779
52Choline metabolism in cancer_Homo sapiens_hsa052310.79425912
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79263665
54Non-small cell lung cancer_Homo sapiens_hsa052230.77785318
55Pancreatic secretion_Homo sapiens_hsa049720.76716027
56* Neurotrophin signaling pathway_Homo sapiens_hsa047220.76055409
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75745992
58Thyroid hormone synthesis_Homo sapiens_hsa049180.74223668
59mTOR signaling pathway_Homo sapiens_hsa041500.74040001
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73725964
61MAPK signaling pathway_Homo sapiens_hsa040100.71863436
62VEGF signaling pathway_Homo sapiens_hsa043700.70468520
63Collecting duct acid secretion_Homo sapiens_hsa049660.68020452
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66751961
65Rap1 signaling pathway_Homo sapiens_hsa040150.66145996
66Renal cell carcinoma_Homo sapiens_hsa052110.64845867
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64041385
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63290486
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62900830
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62493245
71* Ras signaling pathway_Homo sapiens_hsa040140.60979779
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.60730748
73Hedgehog signaling pathway_Homo sapiens_hsa043400.60705526
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59463613
75Bile secretion_Homo sapiens_hsa049760.58424266
76Endocytosis_Homo sapiens_hsa041440.57188547
77Cardiac muscle contraction_Homo sapiens_hsa042600.56480182
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56226345
79Glucagon signaling pathway_Homo sapiens_hsa049220.54118645
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52941988
81Basal cell carcinoma_Homo sapiens_hsa052170.52827321
82* Alcoholism_Homo sapiens_hsa050340.52173252
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52168324
84Circadian rhythm_Homo sapiens_hsa047100.50940714
85Wnt signaling pathway_Homo sapiens_hsa043100.50460719
86Phototransduction_Homo sapiens_hsa047440.50321273
87Colorectal cancer_Homo sapiens_hsa052100.49757323
88Prion diseases_Homo sapiens_hsa050200.45810624
89* Insulin signaling pathway_Homo sapiens_hsa049100.45691407
90Ovarian steroidogenesis_Homo sapiens_hsa049130.45654325
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45293046
92ECM-receptor interaction_Homo sapiens_hsa045120.43579045
93Inositol phosphate metabolism_Homo sapiens_hsa005620.43006466
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41442805
95Fatty acid biosynthesis_Homo sapiens_hsa000610.40964962
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40366434
97Vibrio cholerae infection_Homo sapiens_hsa051100.39734514
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39291203
99Type I diabetes mellitus_Homo sapiens_hsa049400.39286498
100* Chemokine signaling pathway_Homo sapiens_hsa040620.38222572
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.37657821
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37171634
103Hippo signaling pathway_Homo sapiens_hsa043900.34579936
104* Focal adhesion_Homo sapiens_hsa045100.34502245
105Adherens junction_Homo sapiens_hsa045200.32473978
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32374217
107Protein digestion and absorption_Homo sapiens_hsa049740.31424014
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31312779
109Tight junction_Homo sapiens_hsa045300.30395843
110AMPK signaling pathway_Homo sapiens_hsa041520.29734324
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26417753

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