

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | locomotory exploration behavior (GO:0035641) | 6.30883184 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.28844021 |
| 3 | synaptic vesicle maturation (GO:0016188) | 6.24395653 |
| 4 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.98805332 |
| 5 | vocalization behavior (GO:0071625) | 5.73244471 |
| 6 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.52242003 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.34266105 |
| 8 | synaptic vesicle exocytosis (GO:0016079) | 5.16887023 |
| 9 | dendritic spine morphogenesis (GO:0060997) | 5.14542285 |
| 10 | glutamate secretion (GO:0014047) | 5.11682585 |
| 11 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 5.06714580 |
| 12 | neuronal action potential propagation (GO:0019227) | 5.05569463 |
| 13 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.01990549 |
| 14 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.92842304 |
| 15 | regulation of synapse structural plasticity (GO:0051823) | 4.89303661 |
| 16 | layer formation in cerebral cortex (GO:0021819) | 4.88095447 |
| 17 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.85822231 |
| 18 | protein localization to synapse (GO:0035418) | 4.76966448 |
| 19 | exploration behavior (GO:0035640) | 4.72836687 |
| 20 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.70475334 |
| 21 | neuron cell-cell adhesion (GO:0007158) | 4.67400494 |
| 22 | presynaptic membrane assembly (GO:0097105) | 4.63359980 |
| 23 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.57768137 |
| 24 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.46163783 |
| 25 | neurotransmitter secretion (GO:0007269) | 4.39842582 |
| 26 | presynaptic membrane organization (GO:0097090) | 4.39526450 |
| 27 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.34077145 |
| 28 | regulation of synaptic vesicle transport (GO:1902803) | 4.33460589 |
| 29 | gamma-aminobutyric acid transport (GO:0015812) | 4.18981878 |
| 30 | axon ensheathment in central nervous system (GO:0032291) | 4.15517360 |
| 31 | central nervous system myelination (GO:0022010) | 4.15517360 |
| 32 | amino acid import (GO:0043090) | 4.13601798 |
| 33 | proline transport (GO:0015824) | 4.03298792 |
| 34 | axonal fasciculation (GO:0007413) | 3.98514411 |
| 35 | * synaptic transmission, glutamatergic (GO:0035249) | 3.93728421 |
| 36 | cerebellar granule cell differentiation (GO:0021707) | 3.92650722 |
| 37 | glutamate receptor signaling pathway (GO:0007215) | 3.92365882 |
| 38 | positive regulation of membrane potential (GO:0045838) | 3.91456237 |
| 39 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.89874537 |
| 40 | long-term memory (GO:0007616) | 3.86775474 |
| 41 | auditory behavior (GO:0031223) | 3.85477421 |
| 42 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.82983397 |
| 43 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.80434948 |
| 44 | neuron recognition (GO:0008038) | 3.80003296 |
| 45 | neuromuscular process controlling balance (GO:0050885) | 3.79913348 |
| 46 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.74296906 |
| 47 | sodium ion export (GO:0071436) | 3.74000193 |
| 48 | neuronal ion channel clustering (GO:0045161) | 3.71732125 |
| 49 | * neuron-neuron synaptic transmission (GO:0007270) | 3.70076842 |
| 50 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.69736974 |
| 51 | cellular potassium ion homeostasis (GO:0030007) | 3.65834214 |
| 52 | activation of protein kinase A activity (GO:0034199) | 3.65815587 |
| 53 | response to auditory stimulus (GO:0010996) | 3.65169664 |
| 54 | prepulse inhibition (GO:0060134) | 3.63709389 |
| 55 | regulation of synaptic plasticity (GO:0048167) | 3.60242110 |
| 56 | innervation (GO:0060384) | 3.58300141 |
| 57 | potassium ion homeostasis (GO:0055075) | 3.55461818 |
| 58 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.55318832 |
| 59 | dendrite morphogenesis (GO:0048813) | 3.52802613 |
| 60 | postsynaptic membrane organization (GO:0001941) | 3.51807824 |
| 61 | regulation of postsynaptic membrane potential (GO:0060078) | 3.51664769 |
| 62 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.49914004 |
| 63 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.48254785 |
| 64 | dendritic spine organization (GO:0097061) | 3.47113121 |
| 65 | neurotransmitter transport (GO:0006836) | 3.45943013 |
| 66 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.45885268 |
| 67 | potassium ion import (GO:0010107) | 3.42217473 |
| 68 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.40976947 |
| 69 | positive regulation of synapse maturation (GO:0090129) | 3.40122854 |
| 70 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.38798219 |
| 71 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.36509696 |
| 72 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.35940182 |
| 73 | transmission of nerve impulse (GO:0019226) | 3.33487656 |
| 74 | L-amino acid import (GO:0043092) | 3.31770178 |
| 75 | establishment of mitochondrion localization (GO:0051654) | 3.29258022 |
| 76 | cellular sodium ion homeostasis (GO:0006883) | 3.27436191 |
| 77 | regulation of neurotransmitter secretion (GO:0046928) | 3.25488206 |
| 78 | synaptic vesicle endocytosis (GO:0048488) | 3.25278037 |
| 79 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.25172645 |
| 80 | regulation of neurotransmitter levels (GO:0001505) | 3.23285663 |
| 81 | positive regulation of neurotransmitter transport (GO:0051590) | 3.22796564 |
| 82 | regulation of ARF protein signal transduction (GO:0032012) | 3.22108260 |
| 83 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.21431481 |
| 84 | cell communication by electrical coupling (GO:0010644) | 3.21266028 |
| 85 | glycine transport (GO:0015816) | 3.21093491 |
| 86 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.19205215 |
| 87 | long-term synaptic potentiation (GO:0060291) | 3.18944329 |
| 88 | synapse assembly (GO:0007416) | 3.16658768 |
| 89 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.15997316 |
| 90 | regulation of dendritic spine development (GO:0060998) | 3.14821838 |
| 91 | membrane depolarization during action potential (GO:0086010) | 3.10324086 |
| 92 | vesicle transport along microtubule (GO:0047496) | 3.08697964 |
| 93 | regulation of neurotransmitter transport (GO:0051588) | 3.07811889 |
| 94 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.06011882 |
| 95 | acidic amino acid transport (GO:0015800) | 3.06008127 |
| 96 | positive regulation of dendritic spine development (GO:0060999) | 3.05300706 |
| 97 | membrane hyperpolarization (GO:0060081) | 3.05029472 |
| 98 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.04856110 |
| 99 | neuromuscular synaptic transmission (GO:0007274) | 3.04273995 |
| 100 | social behavior (GO:0035176) | 3.04030662 |
| 101 | intraspecies interaction between organisms (GO:0051703) | 3.04030662 |
| 102 | learning (GO:0007612) | 3.03785938 |
| 103 | establishment of nucleus localization (GO:0040023) | 3.03330730 |
| 104 | neuromuscular process (GO:0050905) | 3.02059729 |
| 105 | mechanosensory behavior (GO:0007638) | 3.01839138 |
| 106 | membrane depolarization (GO:0051899) | 3.00800916 |
| 107 | regulation of vesicle fusion (GO:0031338) | 3.00559247 |
| 108 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.00423176 |
| 109 | positive regulation of synapse assembly (GO:0051965) | 3.00270567 |
| 110 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.00087786 |
| 111 | neurotransmitter uptake (GO:0001504) | 2.97337361 |
| 112 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.96970341 |
| 113 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.95618170 |
| 114 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.94832640 |
| 115 | positive regulation of synaptic transmission (GO:0050806) | 2.94684848 |
| 116 | startle response (GO:0001964) | 2.94293489 |
| 117 | cell migration in hindbrain (GO:0021535) | 2.93850966 |
| 118 | adult walking behavior (GO:0007628) | 2.91176414 |
| 119 | behavioral fear response (GO:0001662) | 2.90980828 |
| 120 | behavioral defense response (GO:0002209) | 2.90980828 |
| 121 | negative regulation of dendrite development (GO:2000171) | 2.90921787 |
| 122 | synapse organization (GO:0050808) | 2.90415779 |
| 123 | regulation of synaptic transmission (GO:0050804) | 2.89379141 |
| 124 | membrane assembly (GO:0071709) | 2.85168023 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.85164517 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.34239968 |
| 3 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.08701581 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.07194289 |
| 5 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.04885089 |
| 6 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.78438761 |
| 7 | * EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.76236784 |
| 8 | * RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.76236784 |
| 9 | * DROSHA_22980978_ChIP-Seq_HELA_Human | 2.70567595 |
| 10 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.67118825 |
| 11 | * JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.63070865 |
| 12 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.54496233 |
| 13 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.54202666 |
| 14 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.53802316 |
| 15 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.50577072 |
| 16 | * SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.45860791 |
| 17 | * SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.38069761 |
| 18 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.33583785 |
| 19 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.28482641 |
| 20 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.27141082 |
| 21 | * EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.27008023 |
| 22 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.24270065 |
| 23 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.22153463 |
| 24 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.20317351 |
| 25 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.16458878 |
| 26 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.15160721 |
| 27 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.97498285 |
| 28 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.90008532 |
| 29 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.83019742 |
| 30 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.76358974 |
| 31 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.68805271 |
| 32 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.66940772 |
| 33 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.65503162 |
| 34 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.53537892 |
| 35 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.49263093 |
| 36 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.45738280 |
| 37 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.43397051 |
| 38 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.42012471 |
| 39 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.36916044 |
| 40 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.34415440 |
| 41 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.34180565 |
| 42 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.32524860 |
| 43 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.31844608 |
| 44 | * RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.31593278 |
| 45 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.31514200 |
| 46 | KDM2B_26808549_Chip-Seq_K562_Human | 1.30167690 |
| 47 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.29362888 |
| 48 | AR_19668381_ChIP-Seq_PC3_Human | 1.28977289 |
| 49 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.28913427 |
| 50 | * EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.27482133 |
| 51 | * PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.25948033 |
| 52 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.23613900 |
| 53 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.23451731 |
| 54 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.23284995 |
| 55 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.22965871 |
| 56 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.22788391 |
| 57 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.22515584 |
| 58 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.22310118 |
| 59 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.22000825 |
| 60 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.20933027 |
| 61 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.20932289 |
| 62 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.20873662 |
| 63 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.19975027 |
| 64 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.19744489 |
| 65 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.18521410 |
| 66 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.16599936 |
| 67 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.16005162 |
| 68 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.14826857 |
| 69 | AR_25329375_ChIP-Seq_VCAP_Human | 1.14630896 |
| 70 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.13117388 |
| 71 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.12621254 |
| 72 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.12541141 |
| 73 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.11287114 |
| 74 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.11155428 |
| 75 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.09247742 |
| 76 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.07401458 |
| 77 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.06952753 |
| 78 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.06105109 |
| 79 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.05434709 |
| 80 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.05072835 |
| 81 | TP53_16413492_ChIP-PET_HCT116_Human | 1.04702597 |
| 82 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.04421694 |
| 83 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.04179254 |
| 84 | TCF4_23295773_ChIP-Seq_U87_Human | 1.03624664 |
| 85 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.03620307 |
| 86 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02799725 |
| 87 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.02778419 |
| 88 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.02511553 |
| 89 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.02283895 |
| 90 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.01168511 |
| 91 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.00781712 |
| 92 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.00627798 |
| 93 | * LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00472903 |
| 94 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00320496 |
| 95 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.00320496 |
| 96 | * SOX9_26525672_Chip-Seq_HEART_Mouse | 0.99929668 |
| 97 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.99366931 |
| 98 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.99070714 |
| 99 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.98142644 |
| 100 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.97792906 |
| 101 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.96722449 |
| 102 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.95680103 |
| 103 | * TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.95642792 |
| 104 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.94002154 |
| 105 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.92994513 |
| 106 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.92569344 |
| 107 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.92207861 |
| 108 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.91774458 |
| 109 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91602863 |
| 110 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.91266164 |
| 111 | RXR_22108803_ChIP-Seq_LS180_Human | 0.91044505 |
| 112 | KDM2B_26808549_Chip-Seq_REH_Human | 0.90517360 |
| 113 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.90210943 |
| 114 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.88377662 |
| 115 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.87049055 |
| 116 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.86117103 |
| 117 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85665539 |
| 118 | * TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.83756733 |
| 119 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.83181169 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 7.11953571 |
| 2 | MP0003880_abnormal_central_pattern | 4.49304389 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.29375271 |
| 4 | MP0004270_analgesia | 3.97258228 |
| 5 | MP0002063_abnormal_learning/memory/cond | 3.47758433 |
| 6 | MP0009745_abnormal_behavioral_response | 3.39806517 |
| 7 | MP0002822_catalepsy | 3.30517896 |
| 8 | MP0005423_abnormal_somatic_nervous | 3.14802054 |
| 9 | MP0002064_seizures | 3.09610425 |
| 10 | MP0009046_muscle_twitch | 2.90617933 |
| 11 | MP0001968_abnormal_touch/_nociception | 2.77779666 |
| 12 | MP0002572_abnormal_emotion/affect_behav | 2.74481542 |
| 13 | MP0001486_abnormal_startle_reflex | 2.69455918 |
| 14 | MP0002734_abnormal_mechanical_nocicepti | 2.62438582 |
| 15 | MP0002272_abnormal_nervous_system | 2.39192575 |
| 16 | MP0009780_abnormal_chondrocyte_physiolo | 2.19924738 |
| 17 | MP0004858_abnormal_nervous_system | 2.18499494 |
| 18 | MP0000778_abnormal_nervous_system | 2.07327771 |
| 19 | MP0001501_abnormal_sleep_pattern | 1.99477357 |
| 20 | MP0008569_lethality_at_weaning | 1.93016208 |
| 21 | MP0003329_amyloid_beta_deposits | 1.91375281 |
| 22 | MP0002909_abnormal_adrenal_gland | 1.91016761 |
| 23 | MP0004811_abnormal_neuron_physiology | 1.88305231 |
| 24 | MP0002736_abnormal_nociception_after | 1.87450025 |
| 25 | MP0002733_abnormal_thermal_nociception | 1.85433028 |
| 26 | MP0002067_abnormal_sensory_capabilities | 1.83992349 |
| 27 | MP0002184_abnormal_innervation | 1.82266126 |
| 28 | MP0002735_abnormal_chemical_nociception | 1.81114745 |
| 29 | MP0002557_abnormal_social/conspecific_i | 1.81112438 |
| 30 | MP0001970_abnormal_pain_threshold | 1.79488853 |
| 31 | MP0001440_abnormal_grooming_behavior | 1.78968593 |
| 32 | MP0004885_abnormal_endolymph | 1.73904981 |
| 33 | MP0003879_abnormal_hair_cell | 1.73802538 |
| 34 | MP0004924_abnormal_behavior | 1.72860386 |
| 35 | MP0005386_behavior/neurological_phenoty | 1.72860386 |
| 36 | MP0005646_abnormal_pituitary_gland | 1.72270927 |
| 37 | MP0000955_abnormal_spinal_cord | 1.71443424 |
| 38 | MP0000569_abnormal_digit_pigmentation | 1.52206209 |
| 39 | MP0002882_abnormal_neuron_morphology | 1.46851598 |
| 40 | MP0002066_abnormal_motor_capabilities/c | 1.42594347 |
| 41 | MP0003633_abnormal_nervous_system | 1.40745832 |
| 42 | MP0001984_abnormal_olfaction | 1.32306095 |
| 43 | MP0002152_abnormal_brain_morphology | 1.23261557 |
| 44 | MP0003631_nervous_system_phenotype | 1.16631117 |
| 45 | MP0003283_abnormal_digestive_organ | 1.15651916 |
| 46 | MP0005645_abnormal_hypothalamus_physiol | 1.15490078 |
| 47 | MP0003787_abnormal_imprinting | 1.14826755 |
| 48 | MP0001529_abnormal_vocalization | 1.14649242 |
| 49 | MP0001502_abnormal_circadian_rhythm | 1.12195540 |
| 50 | MP0003634_abnormal_glial_cell | 1.09161594 |
| 51 | MP0004142_abnormal_muscle_tone | 1.06802591 |
| 52 | MP0001177_atelectasis | 1.04280442 |
| 53 | MP0003123_paternal_imprinting | 1.02344102 |
| 54 | MP0001905_abnormal_dopamine_level | 1.00226093 |
| 55 | MP0003121_genomic_imprinting | 0.97538360 |
| 56 | MP0003690_abnormal_glial_cell | 0.97146682 |
| 57 | MP0000751_myopathy | 0.96176857 |
| 58 | MP0000631_abnormal_neuroendocrine_gland | 0.95907690 |
| 59 | MP0003075_altered_response_to | 0.95528946 |
| 60 | MP0006276_abnormal_autonomic_nervous | 0.94817771 |
| 61 | MP0001299_abnormal_eye_distance/ | 0.94553575 |
| 62 | MP0004742_abnormal_vestibular_system | 0.93017344 |
| 63 | MP0000566_synostosis | 0.92663328 |
| 64 | MP0008872_abnormal_physiological_respon | 0.90500659 |
| 65 | MP0008961_abnormal_basal_metabolism | 0.89750471 |
| 66 | MP0002069_abnormal_eating/drinking_beha | 0.88483686 |
| 67 | MP0002638_abnormal_pupillary_reflex | 0.88231607 |
| 68 | MP0008874_decreased_physiological_sensi | 0.87000126 |
| 69 | MP0002229_neurodegeneration | 0.85855627 |
| 70 | MP0004233_abnormal_muscle_weight | 0.85552310 |
| 71 | MP0003137_abnormal_impulse_conducting | 0.85215775 |
| 72 | MP0000026_abnormal_inner_ear | 0.84691799 |
| 73 | MP0001188_hyperpigmentation | 0.84142465 |
| 74 | MP0001485_abnormal_pinna_reflex | 0.83594167 |
| 75 | MP0003632_abnormal_nervous_system | 0.83443623 |
| 76 | MP0004085_abnormal_heartbeat | 0.81085982 |
| 77 | MP0002090_abnormal_vision | 0.78531082 |
| 78 | MP0001963_abnormal_hearing_physiology | 0.77950297 |
| 79 | MP0000604_amyloidosis | 0.77063299 |
| 80 | MP0010386_abnormal_urinary_bladder | 0.76720646 |
| 81 | MP0000579_abnormal_nail_morphology | 0.76269743 |
| 82 | MP0000920_abnormal_myelination | 0.76221755 |
| 83 | MP0003938_abnormal_ear_development | 0.75571172 |
| 84 | MP0004147_increased_porphyrin_level | 0.73325869 |
| 85 | MP0005499_abnormal_olfactory_system | 0.73158922 |
| 86 | MP0005394_taste/olfaction_phenotype | 0.73158922 |
| 87 | MP0003861_abnormal_nervous_system | 0.72936251 |
| 88 | MP0005167_abnormal_blood-brain_barrier | 0.72649829 |
| 89 | MP0003122_maternal_imprinting | 0.72305303 |
| 90 | MP0009379_abnormal_foot_pigmentation | 0.71397145 |
| 91 | MP0004145_abnormal_muscle_electrophysio | 0.70805051 |
| 92 | MP0005623_abnormal_meninges_morphology | 0.70417088 |
| 93 | MP0006292_abnormal_olfactory_placode | 0.69838183 |
| 94 | MP0002752_abnormal_somatic_nervous | 0.69720234 |
| 95 | MP0003172_abnormal_lysosome_physiology | 0.68085840 |
| 96 | MP0004215_abnormal_myocardial_fiber | 0.67937411 |
| 97 | MP0005551_abnormal_eye_electrophysiolog | 0.67468007 |
| 98 | MP0002249_abnormal_larynx_morphology | 0.66078420 |
| 99 | MP0000534_abnormal_ureter_morphology | 0.65347542 |
| 100 | MP0005409_darkened_coat_color | 0.65104075 |
| 101 | MP0001346_abnormal_lacrimal_gland | 0.64410229 |
| 102 | MP0001958_emphysema | 0.63322814 |
| 103 | MP0004484_altered_response_of | 0.63064780 |
| 104 | MP0010234_abnormal_vibrissa_follicle | 0.59810170 |
| 105 | MP0005535_abnormal_body_temperature | 0.59591161 |
| 106 | MP0002653_abnormal_ependyma_morphology | 0.58841494 |
| 107 | MP0010769_abnormal_survival | 0.58221589 |
| 108 | MP0002081_perinatal_lethality | 0.57941656 |
| 109 | MP0004133_heterotaxia | 0.57783776 |
| 110 | MP0001943_abnormal_respiration | 0.57518353 |
| 111 | MP0000013_abnormal_adipose_tissue | 0.56616593 |
| 112 | MP0002089_abnormal_postnatal_growth/wei | 0.56298836 |
| 113 | MP0000049_abnormal_middle_ear | 0.56135705 |
| 114 | MP0002082_postnatal_lethality | 0.55623729 |
| 115 | MP0010770_preweaning_lethality | 0.55623729 |
| 116 | MP0004510_myositis | 0.55447773 |
| 117 | MP0010768_mortality/aging | 0.53992633 |
| 118 | MP0005187_abnormal_penis_morphology | 0.53004263 |
| 119 | MP0001986_abnormal_taste_sensitivity | 0.52411209 |
| 120 | MP0004130_abnormal_muscle_cell | 0.50709693 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 7.28699187 |
| 2 | Focal motor seizures (HP:0011153) | 6.75889903 |
| 3 | Focal seizures (HP:0007359) | 5.39704195 |
| 4 | Visual hallucinations (HP:0002367) | 4.43598322 |
| 5 | Epileptic encephalopathy (HP:0200134) | 4.29125564 |
| 6 | Action tremor (HP:0002345) | 3.87684386 |
| 7 | Progressive cerebellar ataxia (HP:0002073) | 3.78021690 |
| 8 | Ankle clonus (HP:0011448) | 3.74432212 |
| 9 | Febrile seizures (HP:0002373) | 3.67902002 |
| 10 | Papilledema (HP:0001085) | 3.60765155 |
| 11 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.56305016 |
| 12 | Poor eye contact (HP:0000817) | 3.48446613 |
| 13 | Absence seizures (HP:0002121) | 3.47955188 |
| 14 | Supranuclear gaze palsy (HP:0000605) | 3.44199887 |
| 15 | Generalized tonic-clonic seizures (HP:0002069) | 3.41782198 |
| 16 | Broad-based gait (HP:0002136) | 3.41072454 |
| 17 | Atonic seizures (HP:0010819) | 3.39234978 |
| 18 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.34750184 |
| 19 | Impaired social interactions (HP:0000735) | 3.21932684 |
| 20 | Abnormal social behavior (HP:0012433) | 3.21932684 |
| 21 | Depression (HP:0000716) | 3.19190950 |
| 22 | Megalencephaly (HP:0001355) | 3.16550288 |
| 23 | Mutism (HP:0002300) | 3.12543186 |
| 24 | Dialeptic seizures (HP:0011146) | 3.11401816 |
| 25 | Dysdiadochokinesis (HP:0002075) | 3.06137109 |
| 26 | Postural instability (HP:0002172) | 2.95518680 |
| 27 | Gaze-evoked nystagmus (HP:0000640) | 2.95206807 |
| 28 | Abnormal eating behavior (HP:0100738) | 2.87842292 |
| 29 | Torticollis (HP:0000473) | 2.86023167 |
| 30 | Truncal ataxia (HP:0002078) | 2.85798257 |
| 31 | Urinary urgency (HP:0000012) | 2.83847742 |
| 32 | Genetic anticipation (HP:0003743) | 2.81980417 |
| 33 | Anxiety (HP:0000739) | 2.75986575 |
| 34 | Dysmetria (HP:0001310) | 2.75228006 |
| 35 | Hyperventilation (HP:0002883) | 2.68199686 |
| 36 | Neurofibrillary tangles (HP:0002185) | 2.65906019 |
| 37 | Stereotypic behavior (HP:0000733) | 2.64046634 |
| 38 | Spastic gait (HP:0002064) | 2.58713499 |
| 39 | Impaired smooth pursuit (HP:0007772) | 2.58148304 |
| 40 | Intention tremor (HP:0002080) | 2.55321315 |
| 41 | Amblyopia (HP:0000646) | 2.55214322 |
| 42 | Drooling (HP:0002307) | 2.55112350 |
| 43 | Excessive salivation (HP:0003781) | 2.55112350 |
| 44 | Akinesia (HP:0002304) | 2.54490576 |
| 45 | Scanning speech (HP:0002168) | 2.54366418 |
| 46 | Ankyloglossia (HP:0010296) | 2.51946228 |
| 47 | Impaired vibratory sensation (HP:0002495) | 2.51424083 |
| 48 | Hemiparesis (HP:0001269) | 2.51311867 |
| 49 | Focal dystonia (HP:0004373) | 2.51170809 |
| 50 | Hemiplegia (HP:0002301) | 2.51058398 |
| 51 | Abnormality of the lower motor neuron (HP:0002366) | 2.48331882 |
| 52 | Cerebral inclusion bodies (HP:0100314) | 2.46706831 |
| 53 | Pointed chin (HP:0000307) | 2.45471957 |
| 54 | Sleep apnea (HP:0010535) | 2.39577574 |
| 55 | Lower limb muscle weakness (HP:0007340) | 2.36258906 |
| 56 | Obstructive sleep apnea (HP:0002870) | 2.34501765 |
| 57 | Fetal akinesia sequence (HP:0001989) | 2.33341011 |
| 58 | Bradykinesia (HP:0002067) | 2.33316014 |
| 59 | Split foot (HP:0001839) | 2.32810733 |
| 60 | Ventricular fibrillation (HP:0001663) | 2.32676571 |
| 61 | Epileptiform EEG discharges (HP:0011182) | 2.29495404 |
| 62 | Dysmetric saccades (HP:0000641) | 2.28030447 |
| 63 | Craniofacial dystonia (HP:0012179) | 2.26720672 |
| 64 | EEG with generalized epileptiform discharges (HP:0011198) | 2.25527512 |
| 65 | Annular pancreas (HP:0001734) | 2.24370264 |
| 66 | Amyotrophic lateral sclerosis (HP:0007354) | 2.22328086 |
| 67 | Termporal pattern (HP:0011008) | 2.22309774 |
| 68 | Insidious onset (HP:0003587) | 2.22309774 |
| 69 | Insomnia (HP:0100785) | 2.21805192 |
| 70 | Turricephaly (HP:0000262) | 2.20313647 |
| 71 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.20287423 |
| 72 | Hypsarrhythmia (HP:0002521) | 2.19156423 |
| 73 | Aplasia involving bones of the extremities (HP:0009825) | 2.18966420 |
| 74 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.18966420 |
| 75 | Aplasia of the phalanges of the hand (HP:0009802) | 2.18966420 |
| 76 | Abnormality of binocular vision (HP:0011514) | 2.18487762 |
| 77 | Diplopia (HP:0000651) | 2.18487762 |
| 78 | Lower limb amyotrophy (HP:0007210) | 2.16770785 |
| 79 | Bronchomalacia (HP:0002780) | 2.15535493 |
| 80 | Progressive inability to walk (HP:0002505) | 2.12757961 |
| 81 | Peripheral hypomyelination (HP:0007182) | 2.11287079 |
| 82 | Polyphagia (HP:0002591) | 2.07947792 |
| 83 | Clonus (HP:0002169) | 2.06015608 |
| 84 | Blue irides (HP:0000635) | 2.03668144 |
| 85 | Abnormality of the corticospinal tract (HP:0002492) | 2.03217895 |
| 86 | Aqueductal stenosis (HP:0002410) | 2.03141192 |
| 87 | Bundle branch block (HP:0011710) | 2.01248208 |
| 88 | Status epilepticus (HP:0002133) | 2.00672770 |
| 89 | Abnormal EKG (HP:0003115) | 1.98732810 |
| 90 | Absent speech (HP:0001344) | 1.97012709 |
| 91 | Tetraplegia (HP:0002445) | 1.95577074 |
| 92 | Inappropriate behavior (HP:0000719) | 1.95176968 |
| 93 | Resting tremor (HP:0002322) | 1.93563187 |
| 94 | Apathy (HP:0000741) | 1.92023248 |
| 95 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.90359528 |
| 96 | Delusions (HP:0000746) | 1.90061261 |
| 97 | Limb dystonia (HP:0002451) | 1.88983213 |
| 98 | Neuronal loss in central nervous system (HP:0002529) | 1.87940580 |
| 99 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.84747984 |
| 100 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.84747984 |
| 101 | Cerebral hypomyelination (HP:0006808) | 1.83949407 |
| 102 | Pheochromocytoma (HP:0002666) | 1.83440334 |
| 103 | Mild short stature (HP:0003502) | 1.83180653 |
| 104 | Generalized myoclonic seizures (HP:0002123) | 1.82922947 |
| 105 | Intellectual disability, profound (HP:0002187) | 1.78002062 |
| 106 | Spastic tetraparesis (HP:0001285) | 1.77800786 |
| 107 | Hypoplasia of the corpus callosum (HP:0002079) | 1.74718845 |
| 108 | Thickened helices (HP:0000391) | 1.74531803 |
| 109 | Inability to walk (HP:0002540) | 1.74194776 |
| 110 | Truncus arteriosus (HP:0001660) | 1.73973743 |
| 111 | Abnormality of oral frenula (HP:0000190) | 1.72230260 |
| 112 | Agitation (HP:0000713) | 1.71991715 |
| 113 | Incomplete penetrance (HP:0003829) | 1.71619045 |
| 114 | Gait ataxia (HP:0002066) | 1.71194867 |
| 115 | Autism (HP:0000717) | 1.68172730 |
| 116 | Cutaneous finger syndactyly (HP:0010554) | 1.67597037 |
| 117 | Abnormality of saccadic eye movements (HP:0000570) | 1.66601434 |
| 118 | Shallow orbits (HP:0000586) | 1.64644078 |
| 119 | Vertebral arch anomaly (HP:0008438) | 1.63987326 |
| 120 | Lower limb asymmetry (HP:0100559) | 1.59876870 |
| 121 | Hypoventilation (HP:0002791) | 1.57560508 |
| 122 | Coronal craniosynostosis (HP:0004440) | 1.57378515 |
| 123 | Tracheomalacia (HP:0002779) | 1.57168409 |
| 124 | Rigidity (HP:0002063) | 1.56760094 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 4.66517405 |
| 2 | MARK1 | 4.19473095 |
| 3 | MAP3K9 | 4.11563634 |
| 4 | NTRK3 | 3.97761328 |
| 5 | KSR1 | 2.85359847 |
| 6 | MINK1 | 2.85068189 |
| 7 | MAP3K4 | 2.67116492 |
| 8 | DAPK2 | 2.65795523 |
| 9 | PAK6 | 2.57489259 |
| 10 | PRKD3 | 2.50025863 |
| 11 | KSR2 | 2.20668152 |
| 12 | CAMKK1 | 2.14288069 |
| 13 | MAP2K7 | 2.03829615 |
| 14 | * NTRK2 | 1.91581743 |
| 15 | CDK5 | 1.62959774 |
| 16 | RIPK4 | 1.55028504 |
| 17 | DAPK1 | 1.50404126 |
| 18 | TNIK | 1.49907130 |
| 19 | TAOK1 | 1.43740276 |
| 20 | MAP2K4 | 1.42514237 |
| 21 | SIK3 | 1.40719599 |
| 22 | STK38 | 1.38102479 |
| 23 | LATS2 | 1.35309665 |
| 24 | TYRO3 | 1.33561505 |
| 25 | MAPK13 | 1.31138508 |
| 26 | PHKG1 | 1.30360675 |
| 27 | PHKG2 | 1.30360675 |
| 28 | CASK | 1.29318740 |
| 29 | PRPF4B | 1.24438696 |
| 30 | SIK2 | 1.21455766 |
| 31 | PRKCG | 1.08441280 |
| 32 | MAP3K2 | 1.07583617 |
| 33 | STK11 | 1.07431898 |
| 34 | CDK18 | 1.01903050 |
| 35 | PLK2 | 0.99968795 |
| 36 | FES | 0.99266707 |
| 37 | UHMK1 | 0.99250901 |
| 38 | SGK223 | 0.97906854 |
| 39 | SGK494 | 0.97906854 |
| 40 | ALK | 0.96990171 |
| 41 | SGK2 | 0.93650670 |
| 42 | CDK15 | 0.92682448 |
| 43 | PKN1 | 0.92514502 |
| 44 | LMTK2 | 0.90254431 |
| 45 | RET | 0.88910672 |
| 46 | SGK3 | 0.87733507 |
| 47 | MAP3K12 | 0.87586124 |
| 48 | CAMKK2 | 0.86232290 |
| 49 | PAK3 | 0.85679423 |
| 50 | CDK14 | 0.84962410 |
| 51 | ARAF | 0.84739947 |
| 52 | GRK5 | 0.84301969 |
| 53 | PNCK | 0.83074780 |
| 54 | RAF1 | 0.81307847 |
| 55 | CAMK2A | 0.81265610 |
| 56 | MAP3K13 | 0.79879410 |
| 57 | CDK11A | 0.79093646 |
| 58 | CAMK1 | 0.78818344 |
| 59 | PRKCH | 0.78276224 |
| 60 | CAMK2G | 0.77729642 |
| 61 | ROCK2 | 0.75209361 |
| 62 | DYRK2 | 0.72577295 |
| 63 | CDK19 | 0.72363576 |
| 64 | NEK1 | 0.71665987 |
| 65 | SGK1 | 0.71298763 |
| 66 | CSNK1G2 | 0.71232787 |
| 67 | MUSK | 0.70590351 |
| 68 | BCR | 0.70414174 |
| 69 | MAPK12 | 0.69005896 |
| 70 | * NTRK1 | 0.68789510 |
| 71 | BRSK1 | 0.67905759 |
| 72 | RIPK1 | 0.67291211 |
| 73 | SCYL2 | 0.66488425 |
| 74 | EPHB2 | 0.66362171 |
| 75 | MARK2 | 0.63389511 |
| 76 | PRKCZ | 0.63170473 |
| 77 | LIMK1 | 0.62830559 |
| 78 | OXSR1 | 0.61124008 |
| 79 | PDK1 | 0.57977860 |
| 80 | RPS6KA3 | 0.57426429 |
| 81 | TRIB3 | 0.56526484 |
| 82 | ERBB2 | 0.55814601 |
| 83 | CAMK2D | 0.54290945 |
| 84 | DMPK | 0.53881366 |
| 85 | PINK1 | 0.53689089 |
| 86 | DYRK1A | 0.52985167 |
| 87 | PDPK1 | 0.51957055 |
| 88 | FYN | 0.49585670 |
| 89 | MAPK10 | 0.48591138 |
| 90 | CAMK2B | 0.47697001 |
| 91 | MAP3K7 | 0.47327112 |
| 92 | BMPR2 | 0.47148166 |
| 93 | FGFR2 | 0.46913057 |
| 94 | CAMK1G | 0.45624417 |
| 95 | MOS | 0.44687434 |
| 96 | ICK | 0.43680778 |
| 97 | CDC42BPA | 0.42076244 |
| 98 | NEK6 | 0.38416692 |
| 99 | WNK3 | 0.37926218 |
| 100 | MAP3K1 | 0.37126314 |
| 101 | WNK1 | 0.36870865 |
| 102 | PRKCE | 0.36599000 |
| 103 | CAMK4 | 0.35687189 |
| 104 | PRKG1 | 0.35652102 |
| 105 | ROCK1 | 0.35490413 |
| 106 | TAF1 | 0.34367965 |
| 107 | PTK2 | 0.33632181 |
| 108 | DAPK3 | 0.33453464 |
| 109 | PTK2B | 0.33146179 |
| 110 | PDGFRB | 0.33022925 |
| 111 | CCNB1 | 0.32657439 |
| 112 | STK39 | 0.32153523 |
| 113 | CSNK1D | 0.31399136 |
| 114 | AKT3 | 0.31286628 |
| 115 | DDR2 | 0.31263265 |
| 116 | PDGFRA | 0.30359980 |
| 117 | RPS6KA2 | 0.29867748 |
| 118 | CSNK1E | 0.29262721 |
| 119 | RPS6KB1 | 0.28493796 |
| 120 | BRAF | 0.28444610 |
| 121 | GSK3B | 0.26373462 |
| 122 | PRKACA | 0.26359012 |
| 123 | MAPK8 | 0.25925011 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.28063775 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.92306793 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 2.89166655 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.67995050 |
| 5 | GABAergic synapse_Homo sapiens_hsa04727 | 2.60232738 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.53167140 |
| 7 | Long-term potentiation_Homo sapiens_hsa04720 | 2.48546198 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.45135999 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.38129084 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.28244063 |
| 11 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.21918627 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.16865193 |
| 13 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.07627760 |
| 14 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.96680024 |
| 15 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.95042209 |
| 16 | Insulin secretion_Homo sapiens_hsa04911 | 1.92851312 |
| 17 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.87052838 |
| 18 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.85099899 |
| 19 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.69982457 |
| 20 | Cocaine addiction_Homo sapiens_hsa05030 | 1.69697837 |
| 21 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.64255705 |
| 22 | Renin secretion_Homo sapiens_hsa04924 | 1.57490288 |
| 23 | Long-term depression_Homo sapiens_hsa04730 | 1.53337575 |
| 24 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.52183445 |
| 25 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.48795795 |
| 26 | Gap junction_Homo sapiens_hsa04540 | 1.46968189 |
| 27 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.46575628 |
| 28 | Taste transduction_Homo sapiens_hsa04742 | 1.43631845 |
| 29 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.39400348 |
| 30 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.37343102 |
| 31 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.31893695 |
| 32 | Axon guidance_Homo sapiens_hsa04360 | 1.31630048 |
| 33 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.30177315 |
| 34 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.29726330 |
| 35 | * Glioma_Homo sapiens_hsa05214 | 1.28039215 |
| 36 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.24392379 |
| 37 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.23297741 |
| 38 | * Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.20543655 |
| 39 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.17504655 |
| 40 | Melanogenesis_Homo sapiens_hsa04916 | 1.13662274 |
| 41 | * ErbB signaling pathway_Homo sapiens_hsa04012 | 1.12904341 |
| 42 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.10384559 |
| 43 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.07286932 |
| 44 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.04145770 |
| 45 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.01580651 |
| 46 | * Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.94758411 |
| 47 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.90246988 |
| 48 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.87842993 |
| 49 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.87224348 |
| 50 | Endometrial cancer_Homo sapiens_hsa05213 | 0.83516880 |
| 51 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.79614779 |
| 52 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.79425912 |
| 53 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.79263665 |
| 54 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.77785318 |
| 55 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.76716027 |
| 56 | * Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.76055409 |
| 57 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.75745992 |
| 58 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.74223668 |
| 59 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.74040001 |
| 60 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.73725964 |
| 61 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.71863436 |
| 62 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.70468520 |
| 63 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.68020452 |
| 64 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.66751961 |
| 65 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.66145996 |
| 66 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.64845867 |
| 67 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.64041385 |
| 68 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.63290486 |
| 69 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.62900830 |
| 70 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.62493245 |
| 71 | * Ras signaling pathway_Homo sapiens_hsa04014 | 0.60979779 |
| 72 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.60730748 |
| 73 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.60705526 |
| 74 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.59463613 |
| 75 | Bile secretion_Homo sapiens_hsa04976 | 0.58424266 |
| 76 | Endocytosis_Homo sapiens_hsa04144 | 0.57188547 |
| 77 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.56480182 |
| 78 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.56226345 |
| 79 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.54118645 |
| 80 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.52941988 |
| 81 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.52827321 |
| 82 | * Alcoholism_Homo sapiens_hsa05034 | 0.52173252 |
| 83 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.52168324 |
| 84 | Circadian rhythm_Homo sapiens_hsa04710 | 0.50940714 |
| 85 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.50460719 |
| 86 | Phototransduction_Homo sapiens_hsa04744 | 0.50321273 |
| 87 | Colorectal cancer_Homo sapiens_hsa05210 | 0.49757323 |
| 88 | Prion diseases_Homo sapiens_hsa05020 | 0.45810624 |
| 89 | * Insulin signaling pathway_Homo sapiens_hsa04910 | 0.45691407 |
| 90 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.45654325 |
| 91 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.45293046 |
| 92 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.43579045 |
| 93 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.43006466 |
| 94 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.41442805 |
| 95 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.40964962 |
| 96 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.40366434 |
| 97 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.39734514 |
| 98 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.39291203 |
| 99 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.39286498 |
| 100 | * Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.38222572 |
| 101 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.37657821 |
| 102 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.37171634 |
| 103 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.34579936 |
| 104 | * Focal adhesion_Homo sapiens_hsa04510 | 0.34502245 |
| 105 | Adherens junction_Homo sapiens_hsa04520 | 0.32473978 |
| 106 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.32374217 |
| 107 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.31424014 |
| 108 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.31312779 |
| 109 | Tight junction_Homo sapiens_hsa04530 | 0.30395843 |
| 110 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.29734324 |
| 111 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.26417753 |

