SHC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin metabolic process (GO:0006582)9.78455653
2secondary metabolite biosynthetic process (GO:0044550)8.99892094
3developmental pigmentation (GO:0048066)5.47237925
4neuronal action potential propagation (GO:0019227)4.53530635
5signal peptide processing (GO:0006465)4.29135486
6regulation of somitogenesis (GO:0014807)4.27769109
7phenol-containing compound biosynthetic process (GO:0046189)4.01920222
8detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.00671013
9presynaptic membrane assembly (GO:0097105)3.97294050
10neuron cell-cell adhesion (GO:0007158)3.76659265
11postsynaptic membrane organization (GO:0001941)3.72443269
12indolalkylamine metabolic process (GO:0006586)3.72122344
13tryptophan catabolic process (GO:0006569)3.70186556
14indole-containing compound catabolic process (GO:0042436)3.70186556
15indolalkylamine catabolic process (GO:0046218)3.70186556
16cerebral cortex radially oriented cell migration (GO:0021799)3.65169139
17myelination in peripheral nervous system (GO:0022011)3.64656262
18peripheral nervous system axon ensheathment (GO:0032292)3.64656262
19regulation of timing of cell differentiation (GO:0048505)3.62753121
20presynaptic membrane organization (GO:0097090)3.58127447
21dermatan sulfate biosynthetic process (GO:0030208)3.53942980
22dermatan sulfate metabolic process (GO:0030205)3.51478354
23photoreceptor cell maintenance (GO:0045494)3.47267621
24kynurenine metabolic process (GO:0070189)3.45185175
25negative regulation of homotypic cell-cell adhesion (GO:0034111)3.43161623
26behavioral response to nicotine (GO:0035095)3.41750882
27secondary metabolic process (GO:0019748)3.35035532
28locomotory exploration behavior (GO:0035641)3.32218881
29tachykinin receptor signaling pathway (GO:0007217)3.30763095
30cilium or flagellum-dependent cell motility (GO:0001539)3.23122382
31negative regulation of cytosolic calcium ion concentration (GO:0051481)3.22089816
32inner ear receptor cell differentiation (GO:0060113)3.20907684
33melanocyte differentiation (GO:0030318)3.18475469
34mechanoreceptor differentiation (GO:0042490)3.16616461
35neural tube formation (GO:0001841)3.15959296
36regulation of platelet aggregation (GO:0090330)3.13761284
37central nervous system neuron axonogenesis (GO:0021955)3.12169468
38detection of light stimulus involved in visual perception (GO:0050908)3.11850063
39detection of light stimulus involved in sensory perception (GO:0050962)3.11850063
40reflex (GO:0060004)3.10860258
41establishment of protein localization to Golgi (GO:0072600)3.09601506
42regulation of sarcomere organization (GO:0060297)3.07840312
43somatic stem cell division (GO:0048103)3.07308382
44gamma-aminobutyric acid transport (GO:0015812)3.05843670
45regulation of development, heterochronic (GO:0040034)3.04247666
46chondroitin sulfate catabolic process (GO:0030207)3.01946657
47glycosphingolipid biosynthetic process (GO:0006688)2.99351684
48auditory receptor cell differentiation (GO:0042491)2.98875201
49regulation of hippo signaling (GO:0035330)2.95579807
50tryptophan metabolic process (GO:0006568)2.95167368
51serotonin metabolic process (GO:0042428)2.94250927
52behavioral response to ethanol (GO:0048149)2.91740825
53pigment cell differentiation (GO:0050931)2.89525601
54positive regulation of developmental pigmentation (GO:0048087)2.88212322
55indole-containing compound metabolic process (GO:0042430)2.87879799
56myelin assembly (GO:0032288)2.87620342
57cilium morphogenesis (GO:0060271)2.87526377
58cell differentiation involved in metanephros development (GO:0072202)2.86679481
59chondroitin sulfate biosynthetic process (GO:0030206)2.86102820
60regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.84332022
61central nervous system projection neuron axonogenesis (GO:0021952)2.80534525
62C4-dicarboxylate transport (GO:0015740)2.80183558
63positive regulation of neuroblast proliferation (GO:0002052)2.80079700
64pyrimidine nucleobase catabolic process (GO:0006208)2.79413296
65otic vesicle formation (GO:0030916)2.79135380
66cellular response to sterol (GO:0036315)2.77776571
67regulation of pigment cell differentiation (GO:0050932)2.77503727
68nonmotile primary cilium assembly (GO:0035058)2.76824232
69L-fucose catabolic process (GO:0042355)2.75955774
70fucose catabolic process (GO:0019317)2.75955774
71L-fucose metabolic process (GO:0042354)2.75955774
72transmission of nerve impulse (GO:0019226)2.75216414
73cell-cell junction maintenance (GO:0045217)2.74943654
74limb development (GO:0060173)2.74564402
75appendage development (GO:0048736)2.74564402
76proline transport (GO:0015824)2.73503939
77monoubiquitinated protein deubiquitination (GO:0035520)2.72985782
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72274211
79cranial nerve structural organization (GO:0021604)2.71874265
80righting reflex (GO:0060013)2.71510402
81negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70704671
82protein localization to synapse (GO:0035418)2.69763196
83positive regulation of synapse assembly (GO:0051965)2.68638436
84axoneme assembly (GO:0035082)2.65959626
85cellular ketone body metabolic process (GO:0046950)2.63829781
86retinal cone cell development (GO:0046549)2.63229457
87ensheathment of neurons (GO:0007272)2.62944973
88axon ensheathment (GO:0008366)2.62944973
89benzene-containing compound metabolic process (GO:0042537)2.62525654
90mesenchymal-epithelial cell signaling (GO:0060638)2.61938488
91pigmentation (GO:0043473)2.61491365
92ketone body metabolic process (GO:1902224)2.61424694
93primary amino compound metabolic process (GO:1901160)2.59889332
94cellular biogenic amine catabolic process (GO:0042402)2.59743591
95amine catabolic process (GO:0009310)2.59743591
96neuroepithelial cell differentiation (GO:0060563)2.59699241
97limb bud formation (GO:0060174)2.59127125
98oligodendrocyte differentiation (GO:0048709)2.58330787
99synaptic transmission, glutamatergic (GO:0035249)2.57574256
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57016576
101negative regulation of mast cell activation (GO:0033004)2.56981774
102regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.55248454
103inner ear receptor stereocilium organization (GO:0060122)2.53296593
104cilium organization (GO:0044782)2.52267205
105platelet dense granule organization (GO:0060155)2.52014678
106protein prenylation (GO:0018342)2.51176226
107prenylation (GO:0097354)2.51176226
108protein K11-linked deubiquitination (GO:0035871)2.49624205
109cilium assembly (GO:0042384)2.48868177
110spinal cord association neuron differentiation (GO:0021527)2.47899301
111nucleobase catabolic process (GO:0046113)2.47869708
112negative regulation of platelet activation (GO:0010544)2.45234898
113regulation of short-term neuronal synaptic plasticity (GO:0048172)2.44973021
114myelination (GO:0042552)2.44603856
115urinary tract smooth muscle contraction (GO:0014848)2.44534687
116neurotransmitter-gated ion channel clustering (GO:0072578)2.44333654
117regulation of neuroblast proliferation (GO:1902692)2.44243244
118membrane depolarization during action potential (GO:0086010)2.43213452
119ionotropic glutamate receptor signaling pathway (GO:0035235)2.42838943
120endocardial cushion morphogenesis (GO:0003203)2.42826549
121phasic smooth muscle contraction (GO:0014821)2.42809212
122negative regulation of translation, ncRNA-mediated (GO:0040033)2.42770877
123regulation of translation, ncRNA-mediated (GO:0045974)2.42770877
124negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42770877
125startle response (GO:0001964)2.42344270
126male sex determination (GO:0030238)2.41854845
127protein localization to cilium (GO:0061512)2.41759471
128cerebellar Purkinje cell differentiation (GO:0021702)2.41479018
129vocalization behavior (GO:0071625)2.41194680
130cell differentiation in spinal cord (GO:0021515)2.41183469
131axon ensheathment in central nervous system (GO:0032291)2.40631960
132central nervous system myelination (GO:0022010)2.40631960
133thyroid hormone metabolic process (GO:0042403)2.39594609
134positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.39514480
135positive regulation of cellular amide metabolic process (GO:0034250)2.39482439
136long-term synaptic potentiation (GO:0060291)2.39455554
137protein polyglutamylation (GO:0018095)2.39099674
138regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.39001528
139regulation of posttranscriptional gene silencing (GO:0060147)2.38810983
140regulation of gene silencing by miRNA (GO:0060964)2.38810983
141regulation of gene silencing by RNA (GO:0060966)2.38810983
142response to pheromone (GO:0019236)2.38454436
143G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.37955890
144sulfation (GO:0051923)2.37478101
145fibroblast migration (GO:0010761)2.37376993
146mesenchyme morphogenesis (GO:0072132)2.37312921
147Leydig cell differentiation (GO:0033327)2.37041546
148sphingoid metabolic process (GO:0046519)2.36769557
149DNA double-strand break processing (GO:0000729)2.36495770
150tyrosine metabolic process (GO:0006570)2.36391763
151DNA methylation involved in gamete generation (GO:0043046)2.35971896
152mesenchymal cell differentiation involved in renal system development (GO:2001012)2.35868535
153mesenchymal cell differentiation involved in kidney development (GO:0072161)2.35868535
154nephron tubule development (GO:0072080)2.35470379
155spinal cord motor neuron differentiation (GO:0021522)2.33150506
156enteric nervous system development (GO:0048484)2.33086548
157astrocyte development (GO:0014002)2.30494102
158ganglion development (GO:0061548)2.29955074
159generation of neurons (GO:0048699)2.28319228
160neuronal action potential (GO:0019228)2.27982156
161peripheral nervous system development (GO:0007422)2.27818542
162regulation of homotypic cell-cell adhesion (GO:0034110)2.27522061
163relaxation of smooth muscle (GO:0044557)2.27125622
164regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.26588456
165auditory receptor cell stereocilium organization (GO:0060088)2.26465601
166glial cell migration (GO:0008347)2.26370783
167glutamate receptor signaling pathway (GO:0007215)2.25055522
168renal tubule development (GO:0061326)2.24398526
169regulation of male gonad development (GO:2000018)2.23575173
170exploration behavior (GO:0035640)2.22488665
171regulation of synapse assembly (GO:0051963)2.22089640
172detection of mechanical stimulus involved in sensory perception (GO:0050974)2.21793541
173negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.20781206
174neuronal ion channel clustering (GO:0045161)2.20681195
175neuron-neuron synaptic transmission (GO:0007270)2.20626751
176behavioral response to pain (GO:0048266)2.20040325
177positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.18976916
178long-chain fatty acid biosynthetic process (GO:0042759)2.18232758
179melanin biosynthetic process (GO:0042438)10.7535690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.07147623
2GBX2_23144817_ChIP-Seq_PC3_Human4.25736779
3AR_21572438_ChIP-Seq_LNCaP_Human2.85289028
4VDR_22108803_ChIP-Seq_LS180_Human2.76256832
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65271182
6ZNF274_21170338_ChIP-Seq_K562_Hela2.61782006
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46123430
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.42673218
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.40673557
10* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37898785
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32006261
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26737734
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21953394
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21953394
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18992753
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12690666
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.10487751
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09622142
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09214783
20RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.07697165
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.02270310
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97806568
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.95726669
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.92800566
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.92582949
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.88697053
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87910847
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87827939
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83233525
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82103246
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81969862
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81079344
33* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80568394
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79999102
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72735241
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72317871
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70400369
38TAF15_26573619_Chip-Seq_HEK293_Human1.70063252
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66914640
40BCAT_22108803_ChIP-Seq_LS180_Human1.66559163
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64859549
42SMAD4_21799915_ChIP-Seq_A2780_Human1.63849307
43P300_19829295_ChIP-Seq_ESCs_Human1.60766360
44DROSHA_22980978_ChIP-Seq_HELA_Human1.56336429
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54909497
46CBP_20019798_ChIP-Seq_JUKART_Human1.54909497
47TP53_16413492_ChIP-PET_HCT116_Human1.52163906
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48845372
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48489927
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48442718
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47356399
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.45148511
53FUS_26573619_Chip-Seq_HEK293_Human1.43764922
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.41871378
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39688810
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.37078644
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35814184
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35807622
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35772830
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34974013
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34974013
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34213134
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34170328
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31176391
65* TCF4_22108803_ChIP-Seq_LS180_Human1.30525996
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30200665
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29524786
68REST_21632747_ChIP-Seq_MESCs_Mouse1.29332552
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.29122077
70* STAT3_23295773_ChIP-Seq_U87_Human1.27883805
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27819252
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26095459
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25914155
74RNF2_27304074_Chip-Seq_NSC_Mouse1.25838055
75IGF1R_20145208_ChIP-Seq_DFB_Human1.24893427
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23482146
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.23341941
78SOX2_19829295_ChIP-Seq_ESCs_Human1.22767882
79NANOG_19829295_ChIP-Seq_ESCs_Human1.22767882
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.21925166
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21922840
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.21561028
83TCF4_23295773_ChIP-Seq_U87_Human1.21347962
84TP53_18474530_ChIP-ChIP_U2OS_Human1.21327008
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21155453
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.20948983
87AR_25329375_ChIP-Seq_VCAP_Human1.20821866
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20236725
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19646224
90* ARNT_22903824_ChIP-Seq_MCF-7_Human1.19490525
91* ER_23166858_ChIP-Seq_MCF-7_Human1.17645309
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17250400
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.17191535
94CJUN_26792858_Chip-Seq_BT549_Human1.15904460
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15892085
96P53_22387025_ChIP-Seq_ESCs_Mouse1.15632686
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14942632
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.12778312
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11930881
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.10871176
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.09001971
102RXR_22108803_ChIP-Seq_LS180_Human1.08707334
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.08517480
104CDX2_22108803_ChIP-Seq_LS180_Human1.07922377
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07250941
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07226493
107NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06792143
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06792143
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06343437
110SMAD3_21741376_ChIP-Seq_ESCs_Human1.05358725
111SMAD3_21741376_ChIP-Seq_HESCs_Human1.04908834
112* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04703975
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.04375119
114YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04256342
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03934426
116OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03410388
117* AHR_22903824_ChIP-Seq_MCF-7_Human1.03380761
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02812854
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02469218
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02169838
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02162422
122RUNX2_22187159_ChIP-Seq_PCA_Human1.01400961
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.01141002
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.00660992
125* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00634963
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99596131
127EWS_26573619_Chip-Seq_HEK293_Human0.99394631
128KDM2B_26808549_Chip-Seq_REH_Human0.98993524
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98685626
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96914248
131NFE2_27457419_Chip-Seq_LIVER_Mouse0.96379418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.04617242
2MP0000372_irregular_coat_pigmentation5.60492666
3MP0003136_yellow_coat_color5.46904229
4MP0004381_abnormal_hair_follicle2.90310399
5MP0005377_hearing/vestibular/ear_phenot2.78676438
6MP0003878_abnormal_ear_physiology2.78676438
7MP0003195_calcinosis2.54894554
8MP0002102_abnormal_ear_morphology2.46257866
9MP0001501_abnormal_sleep_pattern2.41867458
10MP0005408_hypopigmentation2.39647264
11MP0005551_abnormal_eye_electrophysiolog2.33332179
12MP0005257_abnormal_intraocular_pressure2.25960215
13MP0002095_abnormal_skin_pigmentation2.25868935
14MP0003941_abnormal_skin_development2.17684530
15MP0002877_abnormal_melanocyte_morpholog2.16466526
16MP0010386_abnormal_urinary_bladder2.03919514
17MP0000015_abnormal_ear_pigmentation2.02731546
18MP0001968_abnormal_touch/_nociception2.02027629
19MP0002938_white_spotting2.01899341
20MP0006276_abnormal_autonomic_nervous1.86475404
21MP0004043_abnormal_pH_regulation1.76750091
22MP0001188_hyperpigmentation1.75475270
23MP0003646_muscle_fatigue1.74442789
24MP0000427_abnormal_hair_cycle1.70148940
25MP0000371_diluted_coat_color1.69701090
26MP0008438_abnormal_cutaneous_collagen1.66842184
27MP0002075_abnormal_coat/hair_pigmentati1.65654148
28MP0000920_abnormal_myelination1.61720855
29MP0005409_darkened_coat_color1.60769163
30MP0001485_abnormal_pinna_reflex1.59530037
31MP0005075_abnormal_melanosome_morpholog1.57236626
32MP0006292_abnormal_olfactory_placode1.55204964
33MP0002736_abnormal_nociception_after1.54472926
34MP0001186_pigmentation_phenotype1.52000259
35MP0005646_abnormal_pituitary_gland1.51632498
36MP0004134_abnormal_chest_morphology1.51614223
37MP0004859_abnormal_synaptic_plasticity1.48223152
38MP0002272_abnormal_nervous_system1.43730570
39MP0000383_abnormal_hair_follicle1.43148768
40MP0004742_abnormal_vestibular_system1.41235859
41MP0001970_abnormal_pain_threshold1.38858525
42MP0005503_abnormal_tendon_morphology1.38473219
43MP0003879_abnormal_hair_cell1.37849180
44MP0004858_abnormal_nervous_system1.37116515
45MP0006072_abnormal_retinal_apoptosis1.36590582
46MP0001963_abnormal_hearing_physiology1.35492308
47MP0002067_abnormal_sensory_capabilities1.35319995
48MP0001324_abnormal_eye_pigmentation1.34505693
49MP0004885_abnormal_endolymph1.34402698
50MP0003950_abnormal_plasma_membrane1.30172319
51MP0005174_abnormal_tail_pigmentation1.29380367
52MP0003880_abnormal_central_pattern1.29063508
53MP0000026_abnormal_inner_ear1.26282741
54MP0005386_behavior/neurological_phenoty1.25883489
55MP0004924_abnormal_behavior1.25883489
56MP0004147_increased_porphyrin_level1.22454702
57MP0002837_dystrophic_cardiac_calcinosis1.21886306
58MP0009250_abnormal_appendicular_skeleto1.21466305
59MP0004272_abnormal_basement_membrane1.19896856
60MP0000778_abnormal_nervous_system1.19408775
61MP0000538_abnormal_urinary_bladder1.19339595
62MP0005623_abnormal_meninges_morphology1.18958672
63MP0005248_abnormal_Harderian_gland1.18557467
64MP0005645_abnormal_hypothalamus_physiol1.18378432
65MP0002638_abnormal_pupillary_reflex1.15281010
66MP0000569_abnormal_digit_pigmentation1.14567939
67MP0002876_abnormal_thyroid_physiology1.13914755
68MP0006054_spinal_hemorrhage1.13354105
69MP0000534_abnormal_ureter_morphology1.12390593
70MP0003787_abnormal_imprinting1.12313048
71MP0002184_abnormal_innervation1.10176123
72MP0008057_abnormal_DNA_replication1.09717294
73MP0009046_muscle_twitch1.09624174
74MP0002735_abnormal_chemical_nociception1.06566149
75MP0000631_abnormal_neuroendocrine_gland1.05819824
76MP0003635_abnormal_synaptic_transmissio1.04572677
77MP0002557_abnormal_social/conspecific_i1.03746110
78MP0003634_abnormal_glial_cell1.03727869
79MP0000566_synostosis1.02479937
80MP0002734_abnormal_mechanical_nocicepti0.97439217
81MP0003633_abnormal_nervous_system0.95964528
82MP0002928_abnormal_bile_duct0.94366587
83MP0010678_abnormal_skin_adnexa0.93130279
84MP0003385_abnormal_body_wall0.92897146
85MP0002229_neurodegeneration0.92592279
86MP0003937_abnormal_limbs/digits/tail_de0.92273719
87MP0008872_abnormal_physiological_respon0.91964271
88MP0005379_endocrine/exocrine_gland_phen0.91789875
89MP0001486_abnormal_startle_reflex0.91772886
90MP0008569_lethality_at_weaning0.91187223
91MP0005195_abnormal_posterior_eye0.90762167
92MP0001958_emphysema0.90546612
93MP0002751_abnormal_autonomic_nervous0.89422501
94MP0001299_abnormal_eye_distance/0.88837821
95MP0002909_abnormal_adrenal_gland0.88668321
96MP0000049_abnormal_middle_ear0.88550164
97MP0005670_abnormal_white_adipose0.87920957
98MP0002168_other_aberrant_phenotype0.87703290
99MP0004142_abnormal_muscle_tone0.87688407
100MP0004145_abnormal_muscle_electrophysio0.87626584
101MP0003890_abnormal_embryonic-extraembry0.86860579
102MP0002009_preneoplasia0.86573231
103MP0001984_abnormal_olfaction0.86306042
104MP0002089_abnormal_postnatal_growth/wei0.85987920
105MP0002090_abnormal_vision0.85355545
106MP0003942_abnormal_urinary_system0.83481283
107MP0002064_seizures0.83221280
108MP0009745_abnormal_behavioral_response0.81974297
109MP0003045_fibrosis0.80793951
110MP0002177_abnormal_outer_ear0.80384952
111MP0000647_abnormal_sebaceous_gland0.80096621
112MP0005253_abnormal_eye_physiology0.79766342
113MP0004085_abnormal_heartbeat0.79554642
114MP0002653_abnormal_ependyma_morphology0.79163397
115MP0005197_abnormal_uvea_morphology0.76828779
116MP0005423_abnormal_somatic_nervous0.76826329
117MP0002249_abnormal_larynx_morphology0.74869669
118MP0001905_abnormal_dopamine_level0.74249819
119MP0002752_abnormal_somatic_nervous0.73999947
120MP0000762_abnormal_tongue_morphology0.73218930
121MP0001529_abnormal_vocalization0.73089080
122MP0002063_abnormal_learning/memory/cond0.72869951
123MP0002572_abnormal_emotion/affect_behav0.72604112
124MP0002109_abnormal_limb_morphology0.72438131
125MP0001664_abnormal_digestion0.72414347
126MP0002882_abnormal_neuron_morphology0.72335346
127MP0000516_abnormal_urinary_system0.72124623
128MP0005367_renal/urinary_system_phenotyp0.72124623
129MP0002733_abnormal_thermal_nociception0.71713767
130MP0000955_abnormal_spinal_cord0.71311699
131MP0002233_abnormal_nose_morphology0.70760280
132MP0009697_abnormal_copulation0.68709808
133MP0000751_myopathy0.68530387
134MP0005508_abnormal_skeleton_morphology0.68385928
135MP0004270_analgesia0.66181035
136MP0001986_abnormal_taste_sensitivity0.65175461
137MP0001502_abnormal_circadian_rhythm0.64030319
138MP0000749_muscle_degeneration0.62889252
139MP0000733_abnormal_muscle_development0.62840369
140MP0008877_abnormal_DNA_methylation0.60862194

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)8.19871258
2Segmental peripheral demyelination/remyelination (HP:0003481)6.43688573
3Blue irides (HP:0000635)5.48664111
4Aplasia/Hypoplasia of the fovea (HP:0008060)5.48297797
5Hypoplasia of the fovea (HP:0007750)5.48297797
6Upper limb muscle weakness (HP:0003484)5.34598887
7Aplasia/Hypoplasia of the macula (HP:0008059)5.01059780
8White forelock (HP:0002211)4.80686679
9Impaired proprioception (HP:0010831)4.73721514
10Aplasia/Hypoplasia affecting the retina (HP:0008061)4.65113274
11Abnormality of the fovea (HP:0000493)4.58324028
12Insidious onset (HP:0003587)4.38523519
13Termporal pattern (HP:0011008)4.38523519
14Patchy hypopigmentation of hair (HP:0011365)4.35215194
15Pancreatic cysts (HP:0001737)4.27485588
16Action tremor (HP:0002345)4.18375294
17Peripheral hypomyelination (HP:0007182)4.14768960
18Hyperventilation (HP:0002883)4.05543215
19Congenital sensorineural hearing impairment (HP:0008527)4.02370587
20Abnormal auditory evoked potentials (HP:0006958)3.85292365
21Genetic anticipation (HP:0003743)3.83022143
22Gaze-evoked nystagmus (HP:0000640)3.80355245
23Steppage gait (HP:0003376)3.63538969
24Heterochromia iridis (HP:0001100)3.37992148
25Chronic hepatic failure (HP:0100626)3.34099158
26Progressive cerebellar ataxia (HP:0002073)3.32843445
27Ocular albinism (HP:0001107)3.30237914
28Medial flaring of the eyebrow (HP:0010747)3.24925710
29Attenuation of retinal blood vessels (HP:0007843)3.20439796
30Onion bulb formation (HP:0003383)3.18834814
31Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.11050799
32Hypoplasia of the iris (HP:0007676)3.09137892
33Gait imbalance (HP:0002141)3.05718715
34Congenital stationary night blindness (HP:0007642)3.04108456
35Iris hypopigmentation (HP:0007730)2.98235659
36Abnormality of the renal medulla (HP:0100957)2.90251550
37Abnormality of the renal cortex (HP:0011035)2.90036491
38Decreased motor nerve conduction velocity (HP:0003431)2.89959280
39Congenital primary aphakia (HP:0007707)2.89228900
40Focal seizures (HP:0007359)2.84712484
41Hypopigmentation of the fundus (HP:0007894)2.81908159
42Cystic liver disease (HP:0006706)2.76228319
43Genital tract atresia (HP:0001827)2.76035510
44Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.74317373
45Cerebellar dysplasia (HP:0007033)2.69467325
46Vaginal atresia (HP:0000148)2.68545513
47Dialeptic seizures (HP:0011146)2.64433364
48Epiphyseal dysplasia (HP:0002656)2.64431554
49Hammertoe (HP:0001765)2.64035895
50Nephrogenic diabetes insipidus (HP:0009806)2.64000806
51Bony spicule pigmentary retinopathy (HP:0007737)2.56700940
52Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.54411750
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.48081738
54Retinal dysplasia (HP:0007973)2.46982297
55Facial diplegia (HP:0001349)2.46055267
56Sex reversal (HP:0012245)2.44732011
57Abnormal sex determination (HP:0012244)2.44732011
58Increased CSF protein (HP:0002922)2.44531448
59Abolished electroretinogram (ERG) (HP:0000550)2.42885972
60Progressive sensorineural hearing impairment (HP:0000408)2.40982883
61True hermaphroditism (HP:0010459)2.40951814
62Abnormal pupillary function (HP:0007686)2.39480312
63Occipital encephalocele (HP:0002085)2.39427439
64Broad-based gait (HP:0002136)2.39387227
65Hypoplastic ischia (HP:0003175)2.38156993
66Intestinal atresia (HP:0011100)2.36787789
67Peripheral demyelination (HP:0011096)2.36720103
68Abnormality of the ischium (HP:0003174)2.36635124
69Hemiparesis (HP:0001269)2.29782426
70Absence seizures (HP:0002121)2.27170787
71Aplasia/Hypoplasia of the tongue (HP:0010295)2.24744282
72Widely spaced teeth (HP:0000687)2.24201487
73Atonic seizures (HP:0010819)2.21420105
74Optic nerve hypoplasia (HP:0000609)2.20633684
75Protruding tongue (HP:0010808)2.20121582
76Papilledema (HP:0001085)2.18722152
77Large for gestational age (HP:0001520)2.18078493
78Poor coordination (HP:0002370)2.17153915
79Inability to walk (HP:0002540)2.17026419
80Hypothermia (HP:0002045)2.16283018
81Sclerocornea (HP:0000647)2.14239703
82Constricted visual fields (HP:0001133)2.12311206
83Cupped ear (HP:0000378)2.11365396
84Metaphyseal dysplasia (HP:0100255)2.09435975
85Abnormality of the vocal cords (HP:0008777)2.08701492
86Lissencephaly (HP:0001339)2.08510513
87Congenital hepatic fibrosis (HP:0002612)2.08351221
88Central scotoma (HP:0000603)2.07265275
89Molar tooth sign on MRI (HP:0002419)2.05545713
90Abnormality of midbrain morphology (HP:0002418)2.05545713
91Generalized hypopigmentation (HP:0007513)2.05134342
92Absent speech (HP:0001344)2.04427295
93Progressive inability to walk (HP:0002505)2.02357304
94Abnormality of the labia minora (HP:0012880)2.00757106
95Short foot (HP:0001773)1.99796723
96Postural tremor (HP:0002174)1.99431198
97Aplasia/Hypoplasia of the lens (HP:0008063)1.98707933
98Increased density of long bones (HP:0006392)1.98636377
99Decreased central vision (HP:0007663)1.98610881
100Pancreatic fibrosis (HP:0100732)1.97360094
101Preaxial foot polydactyly (HP:0001841)1.96677257
102Foot dorsiflexor weakness (HP:0009027)1.95574218
103Polydipsia (HP:0001959)1.95557369
104Abnormal drinking behavior (HP:0030082)1.95557369
105Aplasia cutis congenita (HP:0001057)1.95355796
106Dynein arm defect of respiratory motile cilia (HP:0012255)1.95266766
107Absent/shortened dynein arms (HP:0200106)1.95266766
108Stomach cancer (HP:0012126)1.93841283
109Astigmatism (HP:0000483)1.92896872
110Renal cortical cysts (HP:0000803)1.92708888
111Furrowed tongue (HP:0000221)1.92669022
112Clumsiness (HP:0002312)1.92221632
113Anomalous pulmonary venous return (HP:0010772)1.91260057
114Abnormal rod and cone electroretinograms (HP:0008323)1.90049241
115Midline defect of the nose (HP:0004122)1.88469987
116Tubular atrophy (HP:0000092)1.88290051
117Type II lissencephaly (HP:0007260)1.87218927
118Drooling (HP:0002307)1.86421151
119Fair hair (HP:0002286)1.85520850
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84500373
121Nephronophthisis (HP:0000090)1.84284258
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83420975
123Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82620602
124Scotoma (HP:0000575)1.82123870
125Postaxial hand polydactyly (HP:0001162)1.81225714
126Morphological abnormality of the inner ear (HP:0011390)1.80592625
127Cutaneous finger syndactyly (HP:0010554)1.80381509
128Focal motor seizures (HP:0011153)1.79228279
129Abnormality of macular pigmentation (HP:0008002)1.78571804
130Abnormality of calcium-phosphate metabolism (HP:0100530)1.78456829
131Hypoplastic labia majora (HP:0000059)1.77573124
132Febrile seizures (HP:0002373)1.76038206
133Cutaneous syndactyly (HP:0012725)1.74779634
134Abnormality of the foot musculature (HP:0001436)1.74564130
135Pendular nystagmus (HP:0012043)1.74476727
136Humeroradial synostosis (HP:0003041)1.74059874
137Synostosis involving the elbow (HP:0003938)1.74059874
138Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73857146
139Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.73854331
140Generalized hypopigmentation of hair (HP:0011358)1.71518109
141Chorioretinal coloboma (HP:0000567)1.70760876
142Preaxial hand polydactyly (HP:0001177)1.70477646
143Septo-optic dysplasia (HP:0100842)1.67997033
144Small hand (HP:0200055)1.67935123
145Neonatal short-limb short stature (HP:0008921)1.67911057
146Narrow nasal bridge (HP:0000446)1.66702852
147Pulmonary artery stenosis (HP:0004415)1.66698962
148Chorioretinal atrophy (HP:0000533)1.66064326
149Epileptic encephalopathy (HP:0200134)1.66007018
150Abnormality of the pubic bones (HP:0003172)1.66000143
151Increased corneal curvature (HP:0100692)1.65755723
152Keratoconus (HP:0000563)1.65755723
153Retinitis pigmentosa (HP:0000510)1.65691406
154Distal sensory impairment (HP:0002936)1.64669194
155Postaxial foot polydactyly (HP:0001830)1.64518091
156Subacute progressive viral hepatitis (HP:0006572)1.63915515
157Hypoplastic pelvis (HP:0008839)1.63696036
158Meningocele (HP:0002435)1.60055778
159Abnormality of the pulmonary veins (HP:0011718)1.59299559
160Freckling (HP:0001480)1.59261402
161Sprengel anomaly (HP:0000912)1.57500154
162Male pseudohermaphroditism (HP:0000037)1.57118034
163Morphological abnormality of the middle ear (HP:0008609)1.57114350
164Bell-shaped thorax (HP:0001591)1.56612041
165Alacrima (HP:0000522)1.54156622
166Decreased lacrimation (HP:0000633)1.53401613
167Hypoplastic iliac wings (HP:0002866)1.52907290
168Abnormality of incisor morphology (HP:0011063)1.52655055
169Aplasia involving bones of the upper limbs (HP:0009823)1.52541035
170Aplasia of the phalanges of the hand (HP:0009802)1.52541035
171Aplasia involving bones of the extremities (HP:0009825)1.52541035
172Progressive hearing impairment (HP:0001730)1.50221349
173Conical tooth (HP:0000698)1.50026815
174Intellectual disability, moderate (HP:0002342)1.49856689
175Aplasia/hypoplasia of the uterus (HP:0008684)1.49656472
176Anterior segment dysgenesis (HP:0007700)1.47675663
177Fetal akinesia sequence (HP:0001989)1.47207471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.23070069
2CASK7.42793595
3MST1R4.82528283
4PRKD32.98558612
5DDR22.83981328
6IRAK22.78141061
7ACVR1B2.63782022
8IRAK12.51455343
9TNIK2.44899985
10STK38L2.42445419
11NTRK32.27000266
12TRIM282.12772693
13MARK32.11693998
14PDGFRA1.96053649
15IRAK41.95468861
16MAPK131.90200639
17MAP4K21.78406707
18PINK11.78130408
19NEK61.73828915
20MET1.73461260
21LATS11.65866843
22YES11.63642064
23ERBB31.60792576
24RIPK11.59023056
25FGFR21.57968396
26MAP2K71.55320179
27BMX1.51781413
28PIK3CG1.30278806
29BMPR21.25620986
30OXSR11.21574891
31PLK21.20734592
32ZAK1.19260560
33PRPF4B1.17965796
34MUSK1.17058645
35EIF2AK31.17009764
36UHMK11.15150933
37CAMKK21.14819397
38PNCK1.14774031
39MKNK21.13473303
40STK391.07247095
41PHKG21.06359320
42PHKG11.06359320
43CDK31.05114798
44MARK11.02239536
45PRKD21.01068263
46PTK2B0.99875945
47EPHA30.96877931
48CAMKK10.95685058
49TAOK30.95414736
50PAK60.94763744
51PRKCE0.94436590
52MARK20.93736843
53SIK30.90086435
54FES0.86005432
55DAPK20.85507099
56PRKCG0.83461678
57INSRR0.83444388
58PIK3CA0.83244675
59STK380.81112826
60PDK20.79924616
61MAPK150.79866146
62WNK40.79819532
63EPHA40.79398049
64STK30.76189368
65MAP3K40.76118658
66MINK10.75853065
67PDGFRB0.74804836
68SGK20.74462415
69CSNK1G10.72553976
70MAP3K140.70486339
71WNK10.69064832
72PAK30.63833783
73NUAK10.63582717
74LMTK20.63568785
75AKT30.61604619
76TGFBR10.60519471
77MAP3K120.60250097
78RET0.60051889
79PKN10.59135094
80TXK0.56881313
81MAP3K60.55922422
82CAMK10.55190143
83GRK10.53244326
84DYRK20.53108093
85WNK30.52744038
86CDK50.52406746
87TNK20.51998044
88PRKCH0.51838445
89SGK4940.51164142
90SGK2230.51164142
91CSNK1A1L0.49462602
92DYRK1A0.47726336
93MKNK10.46396002
94EIF2AK20.46200718
95BMPR1B0.46191064
96MYLK0.45803223
97ERBB40.45641300
98TRPM70.45384436
99ROCK10.44773577
100CAMK2A0.43398289
101SIK20.42810805
102NLK0.42670439
103PRKACA0.41926713
104NTRK20.41712765
105MELK0.41604851
106PRKCZ0.41121226
107OBSCN0.40936634
108RIPK40.40615997
109SRPK10.39624221
110MAP2K40.39600217
111PRKG10.39524027
112FGFR10.38848666
113BCR0.38550455
114ADRBK10.38291185
115STK110.36938135
116ERBB20.36427878
117KSR10.36157721
118MST40.36119342
119CLK10.34845623
120FGR0.34749764
121CSNK1G30.34146452
122CSNK1D0.34104730
123HIPK20.34047866
124CSNK1A10.33478874
125MAP3K10.32262853
126GRK70.32220770
127PBK0.31759141
128PRKACB0.31636597
129CAMK2B0.31025375
130PRKAA10.30849110
131CHUK0.30371503
132MAP2K60.30186536
133CAMK1G0.29827235
134ADRBK20.29759531
135LIMK10.29745763
136PRKCQ0.29607655
137CDK70.29494974
138CSNK1G20.29055616
139MAP3K70.28967445
140FER0.28767532
141MAPKAPK50.28681113
142TEC0.28494594

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006502.53369005
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.52367871
3Nitrogen metabolism_Homo sapiens_hsa009102.46173647
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.43547335
5Axon guidance_Homo sapiens_hsa043601.92986658
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.85829912
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82471695
8ABC transporters_Homo sapiens_hsa020101.82414728
9Nicotine addiction_Homo sapiens_hsa050331.81333710
10Linoleic acid metabolism_Homo sapiens_hsa005911.76229572
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.74503401
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70706967
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68538164
14Melanoma_Homo sapiens_hsa052181.67986117
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.67529616
16Tryptophan metabolism_Homo sapiens_hsa003801.66439924
17Taste transduction_Homo sapiens_hsa047421.66396926
18Serotonergic synapse_Homo sapiens_hsa047261.65751238
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64800439
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.57864500
21ECM-receptor interaction_Homo sapiens_hsa045121.57175806
22Melanogenesis_Homo sapiens_hsa049161.54430604
23Long-term depression_Homo sapiens_hsa047301.47962652
24Olfactory transduction_Homo sapiens_hsa047401.45045661
25Ether lipid metabolism_Homo sapiens_hsa005651.44890983
26Glutamatergic synapse_Homo sapiens_hsa047241.42261609
27Propanoate metabolism_Homo sapiens_hsa006401.41964235
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.41814651
29Circadian entrainment_Homo sapiens_hsa047131.39857852
30Morphine addiction_Homo sapiens_hsa050321.39285139
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38515431
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36158880
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34220763
34Dorso-ventral axis formation_Homo sapiens_hsa043201.33396249
35Synaptic vesicle cycle_Homo sapiens_hsa047211.29749010
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25090560
37beta-Alanine metabolism_Homo sapiens_hsa004101.23478703
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19626425
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18061677
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16011061
41Sphingolipid metabolism_Homo sapiens_hsa006001.14927600
42Cocaine addiction_Homo sapiens_hsa050301.13325593
43Dopaminergic synapse_Homo sapiens_hsa047281.12278280
44Notch signaling pathway_Homo sapiens_hsa043301.11966895
45Glycerolipid metabolism_Homo sapiens_hsa005611.06518861
46Gap junction_Homo sapiens_hsa045401.06103747
47Amphetamine addiction_Homo sapiens_hsa050311.06103263
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06027472
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05300917
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04235946
51Salivary secretion_Homo sapiens_hsa049701.03529686
52Basal transcription factors_Homo sapiens_hsa030221.02758399
53Cholinergic synapse_Homo sapiens_hsa047251.01837075
54Hedgehog signaling pathway_Homo sapiens_hsa043401.01784712
55Protein export_Homo sapiens_hsa030601.00701924
56Insulin secretion_Homo sapiens_hsa049110.99874864
57Homologous recombination_Homo sapiens_hsa034400.99195898
58Calcium signaling pathway_Homo sapiens_hsa040200.97636458
59Dilated cardiomyopathy_Homo sapiens_hsa054140.97269720
60* Focal adhesion_Homo sapiens_hsa045100.96819134
61Selenocompound metabolism_Homo sapiens_hsa004500.96350294
62Endometrial cancer_Homo sapiens_hsa052130.95081660
63GABAergic synapse_Homo sapiens_hsa047270.94799844
64Ovarian steroidogenesis_Homo sapiens_hsa049130.94714775
65Chemical carcinogenesis_Homo sapiens_hsa052040.94490389
66Retinol metabolism_Homo sapiens_hsa008300.94272504
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93185083
68Tyrosine metabolism_Homo sapiens_hsa003500.92578591
69* ErbB signaling pathway_Homo sapiens_hsa040120.92198209
70Lysine degradation_Homo sapiens_hsa003100.91272971
71Wnt signaling pathway_Homo sapiens_hsa043100.90632913
72* Glioma_Homo sapiens_hsa052140.89806067
73Renin secretion_Homo sapiens_hsa049240.89747299
74Long-term potentiation_Homo sapiens_hsa047200.89538496
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89118249
76Histidine metabolism_Homo sapiens_hsa003400.87847649
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86796228
78Phototransduction_Homo sapiens_hsa047440.83577399
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.82969500
80Phagosome_Homo sapiens_hsa041450.82706275
81Fanconi anemia pathway_Homo sapiens_hsa034600.82482603
82Autoimmune thyroid disease_Homo sapiens_hsa053200.81494382
83Caffeine metabolism_Homo sapiens_hsa002320.81492136
84Collecting duct acid secretion_Homo sapiens_hsa049660.81056315
85MAPK signaling pathway_Homo sapiens_hsa040100.79744057
86* Alcoholism_Homo sapiens_hsa050340.79704627
87Salmonella infection_Homo sapiens_hsa051320.79341165
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.79101851
89Pancreatic secretion_Homo sapiens_hsa049720.78925825
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78611126
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78424981
92Basal cell carcinoma_Homo sapiens_hsa052170.78164330
93Type I diabetes mellitus_Homo sapiens_hsa049400.74905861
94Regulation of autophagy_Homo sapiens_hsa041400.74312994
95Vibrio cholerae infection_Homo sapiens_hsa051100.73856603
96GnRH signaling pathway_Homo sapiens_hsa049120.73748206
97Oxytocin signaling pathway_Homo sapiens_hsa049210.73731793
98* Ras signaling pathway_Homo sapiens_hsa040140.73721086
99Allograft rejection_Homo sapiens_hsa053300.73442450
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72825922
101Malaria_Homo sapiens_hsa051440.72531917
102Prostate cancer_Homo sapiens_hsa052150.71690849
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71321751
104Gastric acid secretion_Homo sapiens_hsa049710.70458575
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69257294
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68237084
107* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68220028
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66902961
109Viral myocarditis_Homo sapiens_hsa054160.66208599
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66164062
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65790092
112Rap1 signaling pathway_Homo sapiens_hsa040150.64796974
113Rheumatoid arthritis_Homo sapiens_hsa053230.63473871
114Protein digestion and absorption_Homo sapiens_hsa049740.63281983
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.62767183
116Renal cell carcinoma_Homo sapiens_hsa052110.62404828
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62267869
118Hippo signaling pathway_Homo sapiens_hsa043900.61816014
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61386259
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60447606
121* Phospholipase D signaling pathway_Homo sapiens_hsa040720.60358663
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59615984
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58951823
124N-Glycan biosynthesis_Homo sapiens_hsa005100.58902648
125Peroxisome_Homo sapiens_hsa041460.58532417
126Choline metabolism in cancer_Homo sapiens_hsa052310.58486186
127Tight junction_Homo sapiens_hsa045300.58153493
128Circadian rhythm_Homo sapiens_hsa047100.57734370
129* MicroRNAs in cancer_Homo sapiens_hsa052060.57652741
130cAMP signaling pathway_Homo sapiens_hsa040240.57485169
131Pathways in cancer_Homo sapiens_hsa052000.56283180
132* Neurotrophin signaling pathway_Homo sapiens_hsa047220.56256265
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55647060
134Proteoglycans in cancer_Homo sapiens_hsa052050.55107511
135Small cell lung cancer_Homo sapiens_hsa052220.53585307
136Arachidonic acid metabolism_Homo sapiens_hsa005900.53392384
137TGF-beta signaling pathway_Homo sapiens_hsa043500.52641671
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.51839910
139African trypanosomiasis_Homo sapiens_hsa051430.50645680
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50240642
141Steroid biosynthesis_Homo sapiens_hsa001000.47196241
142Bile secretion_Homo sapiens_hsa049760.39321653
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38842602
144RNA polymerase_Homo sapiens_hsa030200.38261958
145Type II diabetes mellitus_Homo sapiens_hsa049300.34242588
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.33257534
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31922821
148Mineral absorption_Homo sapiens_hsa049780.30617774
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29073358

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »