SHE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)8.11932031
2endothelium development (GO:0003158)7.14686685
3positive regulation of vasculogenesis (GO:2001214)5.61653690
4blood vessel maturation (GO:0001955)5.55241016
5lymphangiogenesis (GO:0001946)5.47516911
6facial nerve structural organization (GO:0021612)5.41315837
7vascular endothelial growth factor signaling pathway (GO:0038084)5.36819400
8surfactant homeostasis (GO:0043129)5.06989076
9regulation of vasculogenesis (GO:2001212)4.65523497
10regulation of endothelial cell differentiation (GO:0045601)4.65101542
11retina vasculature morphogenesis in camera-type eye (GO:0061299)4.31225414
12cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.30326458
13piRNA metabolic process (GO:0034587)4.18193164
14behavioral response to nicotine (GO:0035095)4.16139891
15sprouting angiogenesis (GO:0002040)4.10066827
16DNA deamination (GO:0045006)4.09263633
17venous blood vessel morphogenesis (GO:0048845)4.09072788
18chemical homeostasis within a tissue (GO:0048875)4.01753958
19endothelial cell differentiation (GO:0045446)4.01440394
20L-fucose catabolic process (GO:0042355)4.01069913
21fucose catabolic process (GO:0019317)4.01069913
22L-fucose metabolic process (GO:0042354)4.01069913
23morphogenesis of an endothelium (GO:0003159)3.95333903
24endothelial tube morphogenesis (GO:0061154)3.95333903
25negative regulation of nitric-oxide synthase activity (GO:0051001)3.90631198
26cellular ketone body metabolic process (GO:0046950)3.89440167
27polyketide metabolic process (GO:0030638)3.85310021
28doxorubicin metabolic process (GO:0044598)3.85310021
29daunorubicin metabolic process (GO:0044597)3.85310021
30cranial nerve structural organization (GO:0021604)3.80298152
31tryptophan catabolic process (GO:0006569)3.77770474
32indole-containing compound catabolic process (GO:0042436)3.77770474
33indolalkylamine catabolic process (GO:0046218)3.77770474
34definitive hemopoiesis (GO:0060216)3.69562856
35positive regulation of endothelial cell differentiation (GO:0045603)3.52503663
36tryptophan metabolic process (GO:0006568)3.51378704
37glomerulus development (GO:0032835)3.50292417
38ventricular trabecula myocardium morphogenesis (GO:0003222)3.45912863
39positive regulation of protein kinase C signaling (GO:0090037)3.45613029
40ketone body metabolic process (GO:1902224)3.44728800
41indolalkylamine metabolic process (GO:0006586)3.42160278
42bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41315820
43regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.38224742
44ovulation from ovarian follicle (GO:0001542)3.36143808
45vasculogenesis (GO:0001570)3.32202566
46embryonic heart tube development (GO:0035050)3.31506395
47Notch signaling involved in heart development (GO:0061314)3.29698110
48heart valve formation (GO:0003188)3.29583860
49patterning of blood vessels (GO:0001569)3.26687594
50vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.25897389
51kynurenine metabolic process (GO:0070189)3.23623215
52cell differentiation involved in metanephros development (GO:0072202)3.18528224
53negative regulation of mast cell activation (GO:0033004)3.17890036
54endothelial cell morphogenesis (GO:0001886)3.14790299
55basement membrane organization (GO:0071711)3.13092702
56gap junction assembly (GO:0016264)3.09362119
57cell migration involved in heart development (GO:0060973)3.07569814
58phosphatidylinositol acyl-chain remodeling (GO:0036149)3.06997663
59atrial cardiac muscle cell action potential (GO:0086014)3.06156412
60positive regulation of smooth muscle cell migration (GO:0014911)3.05690116
61omega-hydroxylase P450 pathway (GO:0097267)3.04385880
62DNA methylation involved in gamete generation (GO:0043046)2.98074608
63heart trabecula morphogenesis (GO:0061384)2.97647722
64ganglion development (GO:0061548)2.96489994
65S-adenosylmethionine metabolic process (GO:0046500)2.95207463
66negative regulation of platelet activation (GO:0010544)2.94391932
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.93972170
68negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.93422088
69autophagic vacuole fusion (GO:0000046)2.92188998
70glomerular basement membrane development (GO:0032836)2.91464843
71mesenchymal cell differentiation involved in kidney development (GO:0072161)2.90592632
72mesenchymal cell differentiation involved in renal system development (GO:2001012)2.90592632
73radial glial cell differentiation (GO:0060019)2.90290563
74glomerular filtration (GO:0003094)2.89345105
75detection of light stimulus involved in visual perception (GO:0050908)2.88304499
76detection of light stimulus involved in sensory perception (GO:0050962)2.88304499
77superoxide anion generation (GO:0042554)2.86569074
78platelet dense granule organization (GO:0060155)2.79544515
79sulfation (GO:0051923)2.79128341
80exogenous drug catabolic process (GO:0042738)2.79057073
81response to folic acid (GO:0051593)2.78790122
82regulation of sequestering of triglyceride (GO:0010889)2.78362140
83mRNA transcription from RNA polymerase II promoter (GO:0042789)2.75982537
84regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.74204725
85negative regulation of endothelial cell apoptotic process (GO:2000352)2.72053002
86axoneme assembly (GO:0035082)2.70495197
87angiogenesis involved in wound healing (GO:0060055)2.70467473
88regulation of somitogenesis (GO:0014807)2.69491463
89regulation of cell proliferation involved in kidney development (GO:1901722)2.68917703
90regulation of sarcomere organization (GO:0060297)2.67646178
91thrombin receptor signaling pathway (GO:0070493)2.66008067
92regulation of establishment or maintenance of cell polarity (GO:0032878)2.64801573
93negative regulation of reactive oxygen species metabolic process (GO:2000378)2.64329174
94auditory receptor cell stereocilium organization (GO:0060088)2.62495559
95histamine secretion (GO:0001821)2.62138828
96multicellular organism reproduction (GO:0032504)2.61484464
97heart trabecula formation (GO:0060347)2.61171507
98cell surface receptor signaling pathway involved in heart development (GO:0061311)2.60196229
99regulation of relaxation of muscle (GO:1901077)2.59742516
100positive regulation of defense response to virus by host (GO:0002230)2.59639818
101protein polyglutamylation (GO:0018095)2.58330118
102drug catabolic process (GO:0042737)2.58177636
103ubiquinone biosynthetic process (GO:0006744)2.57852243
104negative regulation of nitric oxide biosynthetic process (GO:0045019)2.56974500
105negative regulation of keratinocyte proliferation (GO:0010839)2.56589555
106negative regulation of myoblast differentiation (GO:0045662)2.55430205
107cardiac chamber formation (GO:0003207)2.55218723
108trabecula morphogenesis (GO:0061383)2.53651143
109regulation of interleukin-8 secretion (GO:2000482)2.52511818
110positive regulation of fatty acid transport (GO:2000193)2.52094575
111negative regulation of blood vessel endothelial cell migration (GO:0043537)2.51955580
112smooth muscle tissue development (GO:0048745)2.51945056
113endothelial cell proliferation (GO:0001935)2.51607214
114male meiosis I (GO:0007141)2.51476601
115regulation of cellular extravasation (GO:0002691)2.50624439
116negative regulation of vasculature development (GO:1901343)2.49941430
117cytidine metabolic process (GO:0046087)2.49125857
118cytidine catabolic process (GO:0006216)2.49125857
119cytidine deamination (GO:0009972)2.49125857
120indole-containing compound metabolic process (GO:0042430)2.49026169
121retinal cone cell development (GO:0046549)2.48462483
122renal filtration (GO:0097205)2.48013407
123interkinetic nuclear migration (GO:0022027)2.47705411
124transcytosis (GO:0045056)2.47656611
125Notch receptor processing (GO:0007220)2.47652875
126cellular response to exogenous dsRNA (GO:0071360)2.47085164
127establishment of endothelial barrier (GO:0061028)2.46163784
128benzene-containing compound metabolic process (GO:0042537)2.46010260
129regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.45992887
130detection of other organism (GO:0098543)2.45113772
131arginine catabolic process (GO:0006527)2.44348337
132nephron epithelium development (GO:0072009)2.43499951
133negative regulation of endothelial cell migration (GO:0010596)2.42236087
134parturition (GO:0007567)2.41829043
135endoderm formation (GO:0001706)2.41430232
136cell proliferation involved in kidney development (GO:0072111)2.41387549
137negative regulation of blood vessel morphogenesis (GO:2000181)2.41291259
138RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.40818505
139regulation of vascular permeability (GO:0043114)2.40324194
140regulation of actin filament-based movement (GO:1903115)2.39719909
141fatty acid transmembrane transport (GO:1902001)2.38181136
142negative regulation of angiogenesis (GO:0016525)2.36763589
143blood vessel remodeling (GO:0001974)2.36566246
144organelle membrane fusion (GO:0090174)2.36348348
145substrate-dependent cell migration (GO:0006929)2.36049569
146water-soluble vitamin biosynthetic process (GO:0042364)2.35328861
147regulation of meiosis I (GO:0060631)2.35188364
148arginine metabolic process (GO:0006525)2.35047645
149growth hormone receptor signaling pathway (GO:0060396)2.34960695
150regulation of pigment cell differentiation (GO:0050932)2.34705009
151positive regulation of odontogenesis (GO:0042482)2.34609844
152androgen biosynthetic process (GO:0006702)2.34462541
153positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.34374141
154cAMP catabolic process (GO:0006198)2.33973325
155NAD biosynthetic process (GO:0009435)2.33113710
156cardiac ventricle formation (GO:0003211)2.33059535
157regulation of triglyceride catabolic process (GO:0010896)2.32679112
158negative regulation of systemic arterial blood pressure (GO:0003085)2.31377267
159negative regulation of protein autophosphorylation (GO:0031953)2.31064958
160plasma membrane fusion (GO:0045026)2.30908841
161positive regulation of glomerulus development (GO:0090193)2.30350648
162L-methionine salvage (GO:0071267)2.29812341
163L-methionine biosynthetic process (GO:0071265)2.29812341
164amino acid salvage (GO:0043102)2.29812341
165mitochondrial respiratory chain complex I assembly (GO:0032981)2.29418495
166NADH dehydrogenase complex assembly (GO:0010257)2.29418495
167mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.29418495
168negative regulation of synaptic transmission, GABAergic (GO:0032229)2.28067266
169amine catabolic process (GO:0009310)2.27954117
170cellular biogenic amine catabolic process (GO:0042402)2.27954117
171cellular response to ATP (GO:0071318)2.27832068
172nitric oxide mediated signal transduction (GO:0007263)2.27714495
173regulation of action potential (GO:0098900)2.27455162
174regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.27103064
175oxidative demethylation (GO:0070989)2.26990951
176artery development (GO:0060840)2.26494369
177male meiosis (GO:0007140)2.25104331
178negative regulation of telomere maintenance (GO:0032205)2.24228013
179phosphatidylserine acyl-chain remodeling (GO:0036150)2.24032126
180aggressive behavior (GO:0002118)2.22734532
181photoreceptor cell maintenance (GO:0045494)2.21669696
182positive regulation of icosanoid secretion (GO:0032305)2.20968311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.05210044
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.92323081
3VDR_22108803_ChIP-Seq_LS180_Human3.44678789
4ZNF274_21170338_ChIP-Seq_K562_Hela3.37709577
5* GATA2_21666600_ChIP-Seq_HMVEC_Human3.27714210
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.84262970
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.71057433
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.71057433
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.71057433
10IGF1R_20145208_ChIP-Seq_DFB_Human2.63171886
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.51043440
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.50384684
13EZH2_22144423_ChIP-Seq_EOC_Human2.45961998
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.33307427
15PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.32359318
16SCL_19346495_ChIP-Seq_HPC-7_Human2.32278802
17GBX2_23144817_ChIP-Seq_PC3_Human2.20887506
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09237199
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.08567535
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.07650189
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.04602331
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.03453887
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.00312293
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91988567
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91746319
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.91510505
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.89592177
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88656905
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85346869
30* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85329490
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84931206
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.81864896
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80063380
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.79212625
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76367134
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.75737675
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.74096163
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73359202
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72839021
40BCAT_22108803_ChIP-Seq_LS180_Human1.72809889
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71429840
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66770511
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65665685
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.64506800
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63094652
46* ER_23166858_ChIP-Seq_MCF-7_Human1.60308855
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59450735
48* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55724391
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.54978724
50* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53812182
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.53357776
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.51572577
53EWS_26573619_Chip-Seq_HEK293_Human1.50494031
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48871231
55* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47489094
56* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47489094
57IRF1_19129219_ChIP-ChIP_H3396_Human1.47390732
58FUS_26573619_Chip-Seq_HEK293_Human1.47349820
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47145338
60* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47053324
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46356582
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45223594
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44496676
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43142922
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42641388
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41624900
67TP53_22573176_ChIP-Seq_HFKS_Human1.41457196
68* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40500333
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37883406
70NANOG_19829295_ChIP-Seq_ESCs_Human1.37581968
71SOX2_19829295_ChIP-Seq_ESCs_Human1.37581968
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.37215647
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37054117
74CBP_20019798_ChIP-Seq_JUKART_Human1.37054117
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.37003409
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37003409
77* AR_20517297_ChIP-Seq_VCAP_Human1.36518703
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.35788652
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.35317920
80* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34958739
81* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34190969
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34066901
83TCF4_23295773_ChIP-Seq_U87_Human1.32971296
84STAT3_23295773_ChIP-Seq_U87_Human1.32590016
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.31936381
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.30892947
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27310916
88* SMAD4_21799915_ChIP-Seq_A2780_Human1.26677894
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26162494
90* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25611874
91AR_25329375_ChIP-Seq_VCAP_Human1.23494277
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.22254323
93TCF4_22108803_ChIP-Seq_LS180_Human1.22187772
94POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22128039
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.21995645
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21448135
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20049638
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.19848301
99P53_22387025_ChIP-Seq_ESCs_Mouse1.19063470
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.18966032
101NMYC_18555785_Chip-Seq_ESCs_Mouse1.18192459
102ZFX_18555785_Chip-Seq_ESCs_Mouse1.17973803
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17403490
104RUNX_20019798_ChIP-Seq_JUKART_Human1.17148345
105EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16844883
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15915035
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15134113
108* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14854432
109CDX2_22108803_ChIP-Seq_LS180_Human1.14448833
110* NCOR_22424771_ChIP-Seq_293T_Human1.14442252
111RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14277636
112GATA3_26560356_Chip-Seq_TH2_Human1.14265332
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.13853998
114TP53_20018659_ChIP-ChIP_R1E_Mouse1.13516640
115P300_19829295_ChIP-Seq_ESCs_Human1.13159355
116P300_18555785_Chip-Seq_ESCs_Mouse1.11702473
117RNF2_27304074_Chip-Seq_NSC_Mouse1.11175429
118RUNX2_22187159_ChIP-Seq_PCA_Human1.11056732
119TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10295636
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09621801
121TAF15_26573619_Chip-Seq_HEK293_Human1.09435780
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08420251
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.07987259
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07973866
125* SMAD4_21741376_ChIP-Seq_EPCs_Human1.07687300
126SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07187511
127CJUN_26792858_Chip-Seq_BT549_Human1.06479057
128TAF2_19829295_ChIP-Seq_ESCs_Human1.06374943
129NANOG_18555785_Chip-Seq_ESCs_Mouse1.05973695
130FLI1_21867929_ChIP-Seq_TH2_Mouse1.05783745
131* SMAD3_21741376_ChIP-Seq_HESCs_Human1.05634719
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05583168
133* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05234253
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05108533
135GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04676520
136SMAD3_21741376_ChIP-Seq_EPCs_Human1.04326386
137AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04286005
138ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03766460
139OCT4_18555785_Chip-Seq_ESCs_Mouse1.03502604
140* PU1_27457419_Chip-Seq_LIVER_Mouse1.02105077
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01615011
142HOXB7_26014856_ChIP-Seq_BT474_Human1.01420081
143NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00810472
144* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00383658
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00172640
146NANOG_20526341_ChIP-Seq_ESCs_Human1.00102248
147E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99972677
148IRF8_22096565_ChIP-ChIP_GC-B_Human0.99842877
149CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99466123
150TP53_18474530_ChIP-ChIP_U2OS_Human0.99411959
151AHR_22903824_ChIP-Seq_MCF-7_Human0.98899033
152FOXH1_21741376_ChIP-Seq_EPCs_Human0.98657552
153LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97209919
154SOX2_20726797_ChIP-Seq_SW620_Human0.96769530
155MYC_19829295_ChIP-Seq_ESCs_Human0.96725948
156OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96271086
157SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95458459
158FOXH1_21741376_ChIP-Seq_ESCs_Human0.95167430
159POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94268526
160TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94268526
161SOX2_18555785_Chip-Seq_ESCs_Mouse0.93405125
162EZH2_27294783_Chip-Seq_ESCs_Mouse0.93235983
163RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92570492
164PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91560970
165MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90951147
166* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90879621
167SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89754135
168* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89628972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.96991528
2MP0001879_abnormal_lymphatic_vessel5.97020635
3MP0003724_increased_susceptibility_to3.61200083
4MP0004272_abnormal_basement_membrane3.52333064
5MP0005167_abnormal_blood-brain_barrier3.43191121
6MP0003828_pulmonary_edema3.11509348
7MP0001188_hyperpigmentation3.03802758
8MP0005409_darkened_coat_color2.66016779
9MP0006292_abnormal_olfactory_placode2.55355000
10MP0003136_yellow_coat_color2.53761567
11MP0005171_absent_coat_pigmentation2.46317604
12MP0009697_abnormal_copulation2.46083311
13MP0009379_abnormal_foot_pigmentation2.42275193
14MP0003195_calcinosis2.35917951
15MP0004147_increased_porphyrin_level2.29831066
16MP0008877_abnormal_DNA_methylation2.24889861
17MP0002876_abnormal_thyroid_physiology2.13046750
18MP0000767_abnormal_smooth_muscle2.09484382
19MP0005551_abnormal_eye_electrophysiolog2.00338224
20MP0004381_abnormal_hair_follicle1.99890994
21MP0006054_spinal_hemorrhage1.99278121
22MP0008875_abnormal_xenobiotic_pharmacok1.98162662
23MP0000566_synostosis1.96174138
24MP0002837_dystrophic_cardiac_calcinosis1.91890528
25MP0000013_abnormal_adipose_tissue1.88152390
26MP0004782_abnormal_surfactant_physiolog1.87904378
27MP0004084_abnormal_cardiac_muscle1.79612185
28MP0004215_abnormal_myocardial_fiber1.78961026
29MP0002127_abnormal_cardiovascular_syste1.78120531
30MP0001501_abnormal_sleep_pattern1.72268865
31MP0002638_abnormal_pupillary_reflex1.64794865
32MP0003941_abnormal_skin_development1.64579635
33MP0005165_increased_susceptibility_to1.62970348
34MP0001986_abnormal_taste_sensitivity1.59551799
35MP0002138_abnormal_hepatobiliary_system1.58954275
36MP0006138_congestive_heart_failure1.57764588
37MP0008872_abnormal_physiological_respon1.57587906
38MP0004885_abnormal_endolymph1.53737811
39MP0003279_aneurysm1.53370504
40MP0000749_muscle_degeneration1.53297900
41MP0002332_abnormal_exercise_endurance1.52674568
42MP0005595_abnormal_vascular_smooth1.51425951
43MP0004484_altered_response_of1.48498371
44MP0002933_joint_inflammation1.42718292
45MP0004043_abnormal_pH_regulation1.40156367
46MP0005084_abnormal_gallbladder_morpholo1.37618751
47MP0001968_abnormal_touch/_nociception1.37523859
48MP0006276_abnormal_autonomic_nervous1.33637890
49MP0005670_abnormal_white_adipose1.32091241
50MP0008995_early_reproductive_senescence1.30506585
51MP0003252_abnormal_bile_duct1.27907274
52MP0006072_abnormal_retinal_apoptosis1.26316230
53MP0005646_abnormal_pituitary_gland1.23320924
54MP0005085_abnormal_gallbladder_physiolo1.23062312
55MP0000372_irregular_coat_pigmentation1.21783340
56MP0002249_abnormal_larynx_morphology1.21424151
57MP0001544_abnormal_cardiovascular_syste1.20054315
58MP0005385_cardiovascular_system_phenoty1.20054315
59MP0002102_abnormal_ear_morphology1.19651952
60MP0005645_abnormal_hypothalamus_physiol1.19121666
61MP0000343_altered_response_to1.18240085
62MP0005253_abnormal_eye_physiology1.16755402
63MP0005075_abnormal_melanosome_morpholog1.16268084
64MP0008775_abnormal_heart_ventricle1.15516316
65MP0003567_abnormal_fetal_cardiomyocyte1.12508343
66MP0002128_abnormal_blood_circulation1.11864043
67MP0000049_abnormal_middle_ear1.11722749
68MP0000249_abnormal_blood_vessel1.11519749
69MP0005360_urolithiasis1.11260648
70MP0000015_abnormal_ear_pigmentation1.10736872
71MP0005330_cardiomyopathy1.10632171
72MP0004085_abnormal_heartbeat1.10206243
73MP0004130_abnormal_muscle_cell1.09095367
74MP0005410_abnormal_fertilization1.06963215
75MP0003943_abnormal_hepatobiliary_system1.06607200
76MP0000465_gastrointestinal_hemorrhage1.05238018
77MP0002972_abnormal_cardiac_muscle1.04785363
78MP0002925_abnormal_cardiovascular_devel1.03964711
79MP0002009_preneoplasia1.03416549
80MP0003950_abnormal_plasma_membrane0.98378973
81MP0010329_abnormal_lipoprotein_level0.98122009
82MP0001614_abnormal_blood_vessel0.97954605
83MP0002132_abnormal_respiratory_system0.97316749
84MP0003718_maternal_effect0.95741315
85MP0010630_abnormal_cardiac_muscle0.94513009
86MP0002160_abnormal_reproductive_system0.94473796
87MP0003045_fibrosis0.93879479
88MP0005623_abnormal_meninges_morphology0.92643597
89MP0002396_abnormal_hematopoietic_system0.91040534
90MP0002938_white_spotting0.90255331
91MP0003638_abnormal_response/metabolism_0.87945239
92MP0005174_abnormal_tail_pigmentation0.86270957
93MP0004883_abnormal_blood_vessel0.85883977
94MP0003011_delayed_dark_adaptation0.85324342
95MP0000516_abnormal_urinary_system0.85311622
96MP0005367_renal/urinary_system_phenotyp0.85311622
97MP0004036_abnormal_muscle_relaxation0.85265639
98MP0009278_abnormal_bone_marrow0.85110954
99MP0002277_abnormal_respiratory_mucosa0.84557383
100MP0004145_abnormal_muscle_electrophysio0.84390828
101MP0003385_abnormal_body_wall0.84108171
102MP0005620_abnormal_muscle_contractility0.82483844
103MP0002272_abnormal_nervous_system0.82007485
104MP0009745_abnormal_behavioral_response0.79468149
105MP0001905_abnormal_dopamine_level0.79186507
106MP0005248_abnormal_Harderian_gland0.79033505
107MP0004142_abnormal_muscle_tone0.78879291
108MP0009643_abnormal_urine_homeostasis0.78660429
109MP0005389_reproductive_system_phenotype0.78172191
110MP0009764_decreased_sensitivity_to0.77104070
111MP0008004_abnormal_stomach_pH0.75549544
112MP0001915_intracranial_hemorrhage0.75369608
113MP0000266_abnormal_heart_morphology0.75175639
114MP0005365_abnormal_bile_salt0.75043402
115MP0000383_abnormal_hair_follicle0.74954036
116MP0000569_abnormal_digit_pigmentation0.74586538
117MP0003137_abnormal_impulse_conducting0.73599767
118MP0003191_abnormal_cellular_cholesterol0.73355635
119MP0005408_hypopigmentation0.72678530
120MP0005332_abnormal_amino_acid0.72268108
121MP0006036_abnormal_mitochondrial_physio0.72106304
122MP0000230_abnormal_systemic_arterial0.71941885
123MP0002166_altered_tumor_susceptibility0.71448518
124MP0001958_emphysema0.71416834
125MP0002736_abnormal_nociception_after0.70023382
126MP0001800_abnormal_humoral_immune0.69338424
127MP0001486_abnormal_startle_reflex0.69007844
128MP0001485_abnormal_pinna_reflex0.68600778
129MP0009785_altered_susceptibility_to0.68529828
130MP0003122_maternal_imprinting0.68032738
131MP0009046_muscle_twitch0.66830169
132MP0001919_abnormal_reproductive_system0.66406806
133MP0005387_immune_system_phenotype0.64947986
134MP0001790_abnormal_immune_system0.64947986
135MP0000762_abnormal_tongue_morphology0.64828843
136MP0005395_other_phenotype0.64254371
137MP0002177_abnormal_outer_ear0.64156295
138MP0002168_other_aberrant_phenotype0.64072409
139MP0002148_abnormal_hypersensitivity_rea0.64046308
140MP0010386_abnormal_urinary_bladder0.63342600
141MP0002098_abnormal_vibrissa_morphology0.63278474
142MP0004808_abnormal_hematopoietic_stem0.62572525
143MP0001765_abnormal_ion_homeostasis0.62544476
144MP0000427_abnormal_hair_cycle0.62533017
145MP0005464_abnormal_platelet_physiology0.62294689
146MP0003646_muscle_fatigue0.62291141
147MP0001175_abnormal_lung_morphology0.60999379
148MP0002693_abnormal_pancreas_physiology0.60802170
149MP0001784_abnormal_fluid_regulation0.60166845
150MP0001270_distended_abdomen0.59927673
151MP0005164_abnormal_response_to0.59808223
152MP0003935_abnormal_craniofacial_develop0.59460709
153MP0001835_abnormal_antigen_presentation0.59231289
154MP0002295_abnormal_pulmonary_circulatio0.54622587
155MP0002133_abnormal_respiratory_system0.54148996
156MP0005388_respiratory_system_phenotype0.54148996
157MP0000613_abnormal_salivary_gland0.52608623
158MP0005671_abnormal_response_to0.51457368
159MP0001346_abnormal_lacrimal_gland0.51335257

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)4.55196775
2Congenital stationary night blindness (HP:0007642)4.35710592
3Pancreatic cysts (HP:0001737)3.98656181
4Polycythemia (HP:0001901)3.80044176
5Type II lissencephaly (HP:0007260)3.76761163
6Abnormality of the renal cortex (HP:0011035)3.76248867
7Atrial fibrillation (HP:0005110)3.63638283
8Absent hand (HP:0004050)3.63607499
9Abolished electroretinogram (ERG) (HP:0000550)3.55058253
10Pulmonary artery stenosis (HP:0004415)3.49475083
11Abnormality of midbrain morphology (HP:0002418)3.48088033
12Molar tooth sign on MRI (HP:0002419)3.48088033
13Attenuation of retinal blood vessels (HP:0007843)3.40111105
14Pancreatic fibrosis (HP:0100732)3.38622957
15Supraventricular arrhythmia (HP:0005115)3.32693047
16Decreased electroretinogram (ERG) amplitude (HP:0000654)3.30776708
17Capillary hemangiomas (HP:0005306)3.29150195
18Primary atrial arrhythmia (HP:0001692)3.29052166
19Nonprogressive disorder (HP:0003680)3.28330863
20Ventricular tachycardia (HP:0004756)3.22698648
21Nephronophthisis (HP:0000090)3.22372940
22Supraventricular tachycardia (HP:0004755)3.18001042
23Reduced antithrombin III activity (HP:0001976)3.08834850
24True hermaphroditism (HP:0010459)3.08504136
25Aplasia cutis congenita (HP:0001057)3.07677553
26Nonimmune hydrops fetalis (HP:0001790)3.05238179
27Hematochezia (HP:0002573)3.02587019
28Abnormality of the renal medulla (HP:0100957)3.01046753
29Decreased central vision (HP:0007663)2.99305755
30Absent eyebrow (HP:0002223)2.96559090
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95248587
32Abnormality of the axillary hair (HP:0100134)2.91235955
33Abnormality of secondary sexual hair (HP:0009888)2.91235955
34Decreased circulating renin level (HP:0003351)2.85962617
35Abnormal drinking behavior (HP:0030082)2.85741307
36Polydipsia (HP:0001959)2.85741307
37Porencephaly (HP:0002132)2.83108546
38Congenital, generalized hypertrichosis (HP:0004540)2.82316596
39Portal hypertension (HP:0001409)2.82076574
40Esophageal varix (HP:0002040)2.81075045
41Microcytic anemia (HP:0001935)2.76801012
42Prolonged bleeding time (HP:0003010)2.74534578
43Abnormality of the hepatic vasculature (HP:0006707)2.70977382
44Abnormal rod and cone electroretinograms (HP:0008323)2.70657710
45Stomach cancer (HP:0012126)2.66906021
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62076827
47Patchy hypopigmentation of hair (HP:0011365)2.56931671
48Tubular atrophy (HP:0000092)2.56813500
49Joint hemorrhage (HP:0005261)2.54276097
503-Methylglutaconic aciduria (HP:0003535)2.54090502
51Cerebellar dysplasia (HP:0007033)2.52762585
52Type I transferrin isoform profile (HP:0003642)2.51443178
53Cystic liver disease (HP:0006706)2.45627026
54Osteomalacia (HP:0002749)2.45215114
55Chromsome breakage (HP:0040012)2.39303967
56Distal lower limb muscle weakness (HP:0009053)2.37921460
57Thyroiditis (HP:0100646)2.36261611
58Medial flaring of the eyebrow (HP:0010747)2.34585030
59Hypoproteinemia (HP:0003075)2.34434054
60Abnormality of the pulmonary veins (HP:0011718)2.33292943
61Polyuria (HP:0000103)2.33085083
62Adactyly (HP:0009776)2.30831823
63IgG deficiency (HP:0004315)2.30132990
64Fair hair (HP:0002286)2.29177308
65White forelock (HP:0002211)2.28253004
66Pendular nystagmus (HP:0012043)2.28186585
67Intestinal atresia (HP:0011100)2.27071785
68Abnormality of B cell number (HP:0010975)2.25399682
69Tachypnea (HP:0002789)2.24284530
70Hyperventilation (HP:0002883)2.24197534
71Abnormality of alanine metabolism (HP:0010916)2.22587004
72Hyperalaninemia (HP:0003348)2.22587004
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22587004
74Inability to walk (HP:0002540)2.21543252
75Subaortic stenosis (HP:0001682)2.21302426
76Abnormality of the left ventricular outflow tract (HP:0011103)2.21302426
77Sudden death (HP:0001699)2.20485441
78Delayed CNS myelination (HP:0002188)2.19991012
79Congenital sensorineural hearing impairment (HP:0008527)2.17363316
80Hypoplasia of the iris (HP:0007676)2.17158044
81Lipoatrophy (HP:0100578)2.14483295
82Anterior segment dysgenesis (HP:0007700)2.09627881
83Hypothermia (HP:0002045)2.09389249
84Ketosis (HP:0001946)2.09381989
85Skull defect (HP:0001362)2.09261924
86Progressive inability to walk (HP:0002505)2.08011409
87Asymmetry of the thorax (HP:0001555)2.05648946
88Meckel diverticulum (HP:0002245)2.04809578
89Dilated cardiomyopathy (HP:0001644)2.04799288
90Renal cortical cysts (HP:0000803)2.04648302
91Elevated erythrocyte sedimentation rate (HP:0003565)2.02473947
92Mesangial abnormality (HP:0001966)2.01815626
93Chronic hepatic failure (HP:0100626)1.99658139
94Hypoplastic left heart (HP:0004383)1.98914153
95Congenital hepatic fibrosis (HP:0002612)1.98864170
96Abnormal urine output (HP:0012590)1.97866739
97Abnormality of the nasal mucosa (HP:0000433)1.97441807
98Atrioventricular block (HP:0001678)1.96235538
99Hemoptysis (HP:0002105)1.95633498
100Abnormality of the prostate (HP:0008775)1.95336329
101Abnormality of the ileum (HP:0001549)1.95171091
102Retinal dysplasia (HP:0007973)1.94822875
103Pachygyria (HP:0001302)1.94600657
104Tubulointerstitial fibrosis (HP:0005576)1.94221390
105Cerebral hemorrhage (HP:0001342)1.93797138
106Absent eyelashes (HP:0000561)1.92942288
107Abnormal lung lobation (HP:0002101)1.92511580
108Pigmentary retinal degeneration (HP:0001146)1.92345632
109Clumsiness (HP:0002312)1.92130643
110Nephroblastoma (Wilms tumor) (HP:0002667)1.91899417
111Bulbous nose (HP:0000414)1.90858047
112Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90042082
113Abnormality of the renal collecting system (HP:0004742)1.89242525
114Lymphangioma (HP:0100764)1.89223835
115Cerebral palsy (HP:0100021)1.87323690
116Clubbing of toes (HP:0100760)1.86125504
117Gaze-evoked nystagmus (HP:0000640)1.86122088
118Microvesicular hepatic steatosis (HP:0001414)1.85030767
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.84996052
120Sclerocornea (HP:0000647)1.84951273
121Ketoacidosis (HP:0001993)1.84601338
122Type 2 muscle fiber atrophy (HP:0003554)1.84268469
123Generalized hypopigmentation of hair (HP:0011358)1.84088959
124Methylmalonic aciduria (HP:0012120)1.83327561
125Methylmalonic acidemia (HP:0002912)1.82347102
126Dry hair (HP:0011359)1.81843342
127Abnormality of renal excretion (HP:0011036)1.81575153
128Macular degeneration (HP:0000608)1.81425027
129Bundle branch block (HP:0011710)1.79581147
130Optic disc pallor (HP:0000543)1.79467372
131Embryonal renal neoplasm (HP:0011794)1.79427776
132Furrowed tongue (HP:0000221)1.78716767
133Pulmonary hypertension (HP:0002092)1.78533551
134Hyperactive renin-angiotensin system (HP:0000841)1.78417387
135Tubulointerstitial abnormality (HP:0001969)1.78168592
136Supernumerary spleens (HP:0009799)1.77883442
137Duplicated collecting system (HP:0000081)1.77743032
138Eosinophilia (HP:0001880)1.77645237
139Panhypogammaglobulinemia (HP:0003139)1.77178349
140Retinal atrophy (HP:0001105)1.76993034
141Agammaglobulinemia (HP:0004432)1.76414207
142Metabolic alkalosis (HP:0200114)1.76302476
143Bile duct proliferation (HP:0001408)1.76234680
144Abnormal biliary tract physiology (HP:0012439)1.76234680
145Severe muscular hypotonia (HP:0006829)1.75027234
146Abnormality of eosinophils (HP:0001879)1.74670225
147Abnormality of the nasal septum (HP:0000419)1.74595832
148Wrist flexion contracture (HP:0001239)1.73783682
149Hyperglycinuria (HP:0003108)1.73449689
150Stomatitis (HP:0010280)1.73024752
151Weak cry (HP:0001612)1.72777450
152Epistaxis (HP:0000421)1.72238155
153Lymphedema (HP:0001004)1.71992547
154Dicarboxylic aciduria (HP:0003215)1.71982936
155Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71982936
156Hypoplasia of the fovea (HP:0007750)1.71929065
157Aplasia/Hypoplasia of the fovea (HP:0008060)1.71929065
158Orchitis (HP:0100796)1.71046692
159Heart block (HP:0012722)1.70202198
160Aplasia/Hypoplasia of the spleen (HP:0010451)1.70030124
161Male pseudohermaphroditism (HP:0000037)1.69839011
162Abnormality of renin-angiotensin system (HP:0000847)1.68995006
163Pulmonary embolism (HP:0002204)1.67863798
164Hypoplastic heart (HP:0001961)1.66378098
165Menorrhagia (HP:0000132)1.65280816
166Reticulocytopenia (HP:0001896)1.64963715
167Abnormal atrioventricular conduction (HP:0005150)1.64828872
168Craniofacial hyperostosis (HP:0004493)1.62640766
169Midline defect of the nose (HP:0004122)1.62614902
170Keratoconus (HP:0000563)1.60394747
171Increased corneal curvature (HP:0100692)1.60394747
172Abnormality of the phalanges of the hallux (HP:0010057)1.59620324
173Aortic valve stenosis (HP:0001650)1.58901728
174Neonatal death (HP:0003811)1.58744779
175Hypergonadotropic hypogonadism (HP:0000815)1.58707791
176Prolonged QT interval (HP:0001657)1.58146320
177Periorbital edema (HP:0100539)1.57785137
178Prostate neoplasm (HP:0100787)1.57564302
179Optic nerve hypoplasia (HP:0000609)1.56391910
180Abnormality of the fetal cardiovascular system (HP:0010948)1.56354825
181Abnormal umbilical cord blood vessels (HP:0011403)1.56354825
182Single umbilical artery (HP:0001195)1.56354825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.98166947
2KDR5.66241331
3FRK4.32968929
4TGFBR23.53774702
5TAOK33.05252796
6CASK2.66135889
7GRK12.57801717
8MUSK2.55641352
9MKNK22.11174414
10MAP4K22.04966660
11INSRR1.91752557
12ACVR1B1.81486216
13TGFBR11.74189736
14ZAK1.66501208
15IRAK41.63806594
16TLK11.60608978
17IRAK31.60406591
18TEC1.57443169
19MAPKAPK31.57260123
20SRPK11.53094691
21NLK1.52044831
22EPHB21.47873975
23AKT31.45852478
24WNK41.40053789
25MYLK1.39498275
26YES11.38572185
27PRKG21.36321989
28MKNK11.32918096
29ITK1.29235313
30MAP2K31.25396748
31OXSR11.24813802
32DAPK21.23310221
33MAPK151.19914921
34TXK1.17765041
35NME21.12522991
36MAPK131.11317236
37ADRBK21.09527384
38GRK71.03529109
39CLK11.01676732
40NUAK10.99928677
41ADRBK10.99728738
42STK390.98742282
43CDK80.96376455
44PHKG10.94865136
45PHKG20.94865136
46OBSCN0.91859860
47EIF2AK20.91490712
48MAP3K30.90297623
49STK160.89877571
50MAP3K140.89832007
51WNK30.88174076
52NEK90.86016232
53SYK0.85107874
54TNIK0.84805490
55PIK3CG0.80250917
56GRK50.78909586
57TAOK20.76695214
58BLK0.75543281
59IRAK10.74816635
60MAP3K110.74814969
61MAPKAPK50.72758336
62PINK10.71417102
63CSK0.71031087
64MAPK120.70776026
65PRPF4B0.68654066
66MAPK70.66288199
67MAP4K10.65939846
68SIK30.63889759
69PRKD20.62090105
70PTK2B0.60926502
71VRK20.57589880
72CAMKK20.55996337
73PIK3CA0.55609904
74LCK0.54901672
75CDK30.54454513
76PRKCQ0.54272000
77IKBKE0.53558754
78PDK20.52166860
79PRKAA20.51008740
80NEK60.50193774
81CSF1R0.49634400
82BMPR20.48914992
83RPS6KA50.48364491
84IRAK20.47877711
85MARK30.46687360
86STK38L0.46097614
87DMPK0.46058710
88BTK0.44521949
89SGK20.44022854
90FER0.43551697
91MAP3K70.43197810
92FGFR30.42923735
93PAK30.42635427
94CDK90.40811865
95PIM10.40628155
96CAMK40.40606621
97MET0.38217594
98CAMK2A0.37980003
99JAK30.37709691
100VRK10.37503544
101IKBKB0.37400647
102PLK20.37297732
103KIT0.36922151
104PLK40.36866362
105CAMK10.36368475
106EPHA20.36236735
107TNK20.36014479
108HCK0.35905879
109GRK60.35681896
110STK110.35653578
111RPS6KA60.35169883
112PRKCE0.34933894
113IGF1R0.34318161
114BMPR1B0.34186457
115PRKACA0.34096337
116MAP2K20.33993401
117PRKD10.33935857
118CSNK1G10.33860982
119CSNK1G30.32573199
120FES0.31904845
121EPHA30.31294854
122BRD40.31175374
123MAP2K10.30904601
124PRKCA0.30679580
125BCKDK0.30424714
126CDK70.30374741
127CHUK0.29605755
128CSNK1G20.29567696
129MAP2K60.28423664
130LYN0.28104663
131MAP3K10.27963892
132STK30.27792938
133MAP3K60.27608800
134TRPM70.26534936
135PRKG10.26257467
136TBK10.25318131
137FLT30.24768416
138PTK60.24212540
139MAP3K40.23098317
140PRKCG0.22927509
141MATK0.22867042
142ZAP700.21745050
143PKN10.21576421
144ERBB30.19413964
145GSK3A0.19202393
146ABL10.17916634

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.02735263
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.87241633
3Phototransduction_Homo sapiens_hsa047442.35641405
4Asthma_Homo sapiens_hsa053102.29132586
5Nitrogen metabolism_Homo sapiens_hsa009102.27936666
6Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.26364965
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.23324354
8Tryptophan metabolism_Homo sapiens_hsa003802.11597419
9ECM-receptor interaction_Homo sapiens_hsa045122.10246237
10Butanoate metabolism_Homo sapiens_hsa006502.02629046
11Caffeine metabolism_Homo sapiens_hsa002322.00761937
12Fanconi anemia pathway_Homo sapiens_hsa034601.94674932
13Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.94311374
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92914910
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90833790
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.89757789
17Notch signaling pathway_Homo sapiens_hsa043301.88548881
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88262674
19Hematopoietic cell lineage_Homo sapiens_hsa046401.82946120
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80924240
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.79839057
22Ether lipid metabolism_Homo sapiens_hsa005651.78897162
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.76296297
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75825012
25Dilated cardiomyopathy_Homo sapiens_hsa054141.72999922
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.71609314
27Malaria_Homo sapiens_hsa051441.70831900
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66318609
29Type I diabetes mellitus_Homo sapiens_hsa049401.61511769
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60429815
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60386703
32Arachidonic acid metabolism_Homo sapiens_hsa005901.59145203
33Ovarian steroidogenesis_Homo sapiens_hsa049131.57966427
34Adherens junction_Homo sapiens_hsa045201.57532028
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.55087689
36Selenocompound metabolism_Homo sapiens_hsa004501.54176532
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53148028
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.49329287
39Complement and coagulation cascades_Homo sapiens_hsa046101.46503048
40Sphingolipid metabolism_Homo sapiens_hsa006001.45227921
41Focal adhesion_Homo sapiens_hsa045101.42359955
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40929731
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37861941
44Basal cell carcinoma_Homo sapiens_hsa052171.34678019
45Ribosome_Homo sapiens_hsa030101.30929431
46Homologous recombination_Homo sapiens_hsa034401.28199471
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27071801
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25546269
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25390892
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.25366572
51Rap1 signaling pathway_Homo sapiens_hsa040151.23338535
52PI3K-Akt signaling pathway_Homo sapiens_hsa041511.22662618
53Fatty acid degradation_Homo sapiens_hsa000711.20073186
54African trypanosomiasis_Homo sapiens_hsa051431.19364194
55Olfactory transduction_Homo sapiens_hsa047401.19243525
56Small cell lung cancer_Homo sapiens_hsa052221.18113649
57Peroxisome_Homo sapiens_hsa041461.16696632
58Vitamin digestion and absorption_Homo sapiens_hsa049771.15438216
59Measles_Homo sapiens_hsa051621.15246818
60Other glycan degradation_Homo sapiens_hsa005111.14325893
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.14274536
62Staphylococcus aureus infection_Homo sapiens_hsa051501.10633234
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09409865
64Platelet activation_Homo sapiens_hsa046111.06376328
65Primary bile acid biosynthesis_Homo sapiens_hsa001201.05608208
66ABC transporters_Homo sapiens_hsa020101.02882974
67Herpes simplex infection_Homo sapiens_hsa051681.02279413
68Retinol metabolism_Homo sapiens_hsa008301.01656361
69Pathways in cancer_Homo sapiens_hsa052001.00271246
70Serotonergic synapse_Homo sapiens_hsa047260.98591950
71Oxidative phosphorylation_Homo sapiens_hsa001900.97320451
72Antigen processing and presentation_Homo sapiens_hsa046120.94368826
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93186317
74Sulfur metabolism_Homo sapiens_hsa009200.92536751
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92279613
76Glycerolipid metabolism_Homo sapiens_hsa005610.91565932
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.91492137
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.89892648
79Morphine addiction_Homo sapiens_hsa050320.88492651
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86999849
81Histidine metabolism_Homo sapiens_hsa003400.86827896
82Protein export_Homo sapiens_hsa030600.86478258
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86162579
84Dorso-ventral axis formation_Homo sapiens_hsa043200.86079742
85Fatty acid elongation_Homo sapiens_hsa000620.84513035
86Salivary secretion_Homo sapiens_hsa049700.82167343
87Ras signaling pathway_Homo sapiens_hsa040140.80810203
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80806587
89Purine metabolism_Homo sapiens_hsa002300.80012168
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79775557
91Pertussis_Homo sapiens_hsa051330.79412030
92Viral myocarditis_Homo sapiens_hsa054160.79206518
93Leishmaniasis_Homo sapiens_hsa051400.77658654
94Wnt signaling pathway_Homo sapiens_hsa043100.77016573
95Renin secretion_Homo sapiens_hsa049240.76836001
96Cardiac muscle contraction_Homo sapiens_hsa042600.76492629
97Autoimmune thyroid disease_Homo sapiens_hsa053200.75936701
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75644598
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75605533
100Toxoplasmosis_Homo sapiens_hsa051450.75275048
101Primary immunodeficiency_Homo sapiens_hsa053400.74127963
102Tight junction_Homo sapiens_hsa045300.74116638
103Fat digestion and absorption_Homo sapiens_hsa049750.73557652
104Allograft rejection_Homo sapiens_hsa053300.71129842
105Regulation of autophagy_Homo sapiens_hsa041400.71097540
106Protein digestion and absorption_Homo sapiens_hsa049740.69974661
107Circadian entrainment_Homo sapiens_hsa047130.69943427
108Parkinsons disease_Homo sapiens_hsa050120.69067449
109Calcium signaling pathway_Homo sapiens_hsa040200.68783462
110Thyroid cancer_Homo sapiens_hsa052160.67999194
111Graft-versus-host disease_Homo sapiens_hsa053320.66562695
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.66484422
113TNF signaling pathway_Homo sapiens_hsa046680.64978325
114Axon guidance_Homo sapiens_hsa043600.64138777
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64014743
116RNA polymerase_Homo sapiens_hsa030200.63594696
117Basal transcription factors_Homo sapiens_hsa030220.62549812
118RNA degradation_Homo sapiens_hsa030180.60983942
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60119051
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60112530
121Hepatitis C_Homo sapiens_hsa051600.58396501
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57549315
123Insulin secretion_Homo sapiens_hsa049110.56195106
124HTLV-I infection_Homo sapiens_hsa051660.54745727
125Base excision repair_Homo sapiens_hsa034100.51490276
126Nicotine addiction_Homo sapiens_hsa050330.50502764
127TGF-beta signaling pathway_Homo sapiens_hsa043500.50279877
128Chemical carcinogenesis_Homo sapiens_hsa052040.50083503
129Glutamatergic synapse_Homo sapiens_hsa047240.49908665
130Taste transduction_Homo sapiens_hsa047420.49132808
131Prostate cancer_Homo sapiens_hsa052150.47870184
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47839850
133Oxytocin signaling pathway_Homo sapiens_hsa049210.46344139
134Influenza A_Homo sapiens_hsa051640.45887506
135PPAR signaling pathway_Homo sapiens_hsa033200.45269728
136Propanoate metabolism_Homo sapiens_hsa006400.43664180
137Rheumatoid arthritis_Homo sapiens_hsa053230.43056943
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43056083
139Melanogenesis_Homo sapiens_hsa049160.42951038
140Hippo signaling pathway_Homo sapiens_hsa043900.41961540
141Long-term depression_Homo sapiens_hsa047300.41318136
142One carbon pool by folate_Homo sapiens_hsa006700.40995406
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.40258733
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38979825
145MicroRNAs in cancer_Homo sapiens_hsa052060.38595091
146NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38433206
147Osteoclast differentiation_Homo sapiens_hsa043800.37984361
148Fatty acid metabolism_Homo sapiens_hsa012120.37934073
149Tyrosine metabolism_Homo sapiens_hsa003500.36875648
150Alzheimers disease_Homo sapiens_hsa050100.36339463
151Chemokine signaling pathway_Homo sapiens_hsa040620.35502449
152beta-Alanine metabolism_Homo sapiens_hsa004100.35455639
153Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33641144
154Metabolic pathways_Homo sapiens_hsa011000.33400592

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