SHF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of inhibitory postsynaptic membrane potential (GO:0060080)6.71284222
2cerebellar granule cell differentiation (GO:0021707)6.00666025
3locomotory exploration behavior (GO:0035641)5.78412187
4epithelial cell differentiation involved in kidney development (GO:0035850)5.30185322
5synaptic vesicle maturation (GO:0016188)5.13125626
6positive regulation of digestive system process (GO:0060456)5.10904046
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04048400
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.98943542
9negative regulation of systemic arterial blood pressure (GO:0003085)4.95402124
10positive regulation of cAMP-mediated signaling (GO:0043950)4.88989716
11positive regulation of cardiac muscle cell differentiation (GO:2000727)4.85347206
12gamma-aminobutyric acid transport (GO:0015812)4.83088693
13positive regulation of synapse maturation (GO:0090129)4.71239475
14vocalization behavior (GO:0071625)4.67149086
15regulation of cardiac muscle cell contraction (GO:0086004)4.59548508
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.58081043
17cerebellar Purkinje cell differentiation (GO:0021702)4.54770055
18response to pheromone (GO:0019236)4.54402435
19muscle hypertrophy in response to stress (GO:0003299)4.52822917
20cardiac muscle adaptation (GO:0014887)4.52822917
21cardiac muscle hypertrophy in response to stress (GO:0014898)4.52822917
22layer formation in cerebral cortex (GO:0021819)4.52355568
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.46574206
24negative regulation of multicellular organism growth (GO:0040015)4.40186437
25neuronal action potential propagation (GO:0019227)4.39395646
26tryptophan metabolic process (GO:0006568)4.32541870
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.28259603
28sodium ion export (GO:0071436)4.26744374
29DNA replication-dependent nucleosome assembly (GO:0006335)4.26300120
30DNA replication-dependent nucleosome organization (GO:0034723)4.26300120
31neurotransmitter secretion (GO:0007269)4.25136714
32cell differentiation in hindbrain (GO:0021533)4.25009600
33presynaptic membrane organization (GO:0097090)4.22722931
34postsynaptic membrane organization (GO:0001941)4.20823789
35presynaptic membrane assembly (GO:0097105)4.16893017
36adrenergic receptor signaling pathway (GO:0071875)4.16710783
37glutamate secretion (GO:0014047)4.14179553
38glutamate receptor signaling pathway (GO:0007215)4.12567784
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.06645715
40synaptic vesicle exocytosis (GO:0016079)4.04211536
41cellular potassium ion homeostasis (GO:0030007)3.99268412
42neuromuscular process controlling balance (GO:0050885)3.96634383
43membrane hyperpolarization (GO:0060081)3.84091693
44exploration behavior (GO:0035640)3.83197589
45synaptic transmission, glutamatergic (GO:0035249)3.83166939
46behavioral response to nicotine (GO:0035095)3.82145399
47neuromuscular process controlling posture (GO:0050884)3.81073696
48cell migration in hindbrain (GO:0021535)3.78870641
49synaptic vesicle docking involved in exocytosis (GO:0016081)3.77565574
50regulation of glutamate receptor signaling pathway (GO:1900449)3.74577849
51regulation of synaptic vesicle exocytosis (GO:2000300)3.67206324
52dendritic spine morphogenesis (GO:0060997)3.62182802
53nucleobase catabolic process (GO:0046113)3.59223667
54fear response (GO:0042596)3.58199151
55regulation of oxidative phosphorylation (GO:0002082)3.54941955
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53748022
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50077381
58long-term memory (GO:0007616)3.48435642
59protein localization to synapse (GO:0035418)3.47821791
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45165297
61regulation of actin filament-based movement (GO:1903115)3.43750882
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.41023834
63neurotransmitter-gated ion channel clustering (GO:0072578)3.38925672
64regulation of neuronal synaptic plasticity (GO:0048168)3.38918232
65dendrite morphogenesis (GO:0048813)3.37967202
66cellular copper ion homeostasis (GO:0006878)3.36780598
67neuron-neuron synaptic transmission (GO:0007270)3.35397712
68cytoskeletal anchoring at plasma membrane (GO:0007016)3.34317819
69establishment of mitochondrion localization (GO:0051654)3.33502289
70indolalkylamine metabolic process (GO:0006586)3.33168217
71C4-dicarboxylate transport (GO:0015740)3.32878348
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.31972268
73regulation of synapse maturation (GO:0090128)3.31017715
74cell communication by electrical coupling (GO:0010644)3.30298437
75cardiac muscle hypertrophy (GO:0003300)3.29987113
76positive regulation of systemic arterial blood pressure (GO:0003084)3.29970109
77regulation of skeletal muscle cell differentiation (GO:2001014)3.26789447
78serotonin metabolic process (GO:0042428)3.26280019
79synaptic vesicle endocytosis (GO:0048488)3.24672106
80establishment of nucleus localization (GO:0040023)3.22573004
81negative regulation of smooth muscle contraction (GO:0045986)3.21023080
82negative regulation of peptidyl-lysine acetylation (GO:2000757)3.19288381
83mating behavior (GO:0007617)3.18442723
84cerebellar Purkinje cell layer development (GO:0021680)3.17631092
85neurotransmitter transport (GO:0006836)3.16826164
86striated muscle hypertrophy (GO:0014897)3.14571962
87regulation of postsynaptic membrane potential (GO:0060078)3.13734911
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.11757432
89regulation of synaptic vesicle transport (GO:1902803)3.11112898
90response to auditory stimulus (GO:0010996)3.10886844
91axonal fasciculation (GO:0007413)3.10485239
92regulation of cAMP-mediated signaling (GO:0043949)3.10198090
93proline transport (GO:0015824)3.05340150
94gamma-aminobutyric acid signaling pathway (GO:0007214)3.04224577
95neuromuscular process (GO:0050905)3.02800717
96auditory behavior (GO:0031223)3.02534453
97regulation of neurotransmitter levels (GO:0001505)3.02200927
98regulation of somitogenesis (GO:0014807)3.00988898
99musculoskeletal movement (GO:0050881)3.00341085
100multicellular organismal movement (GO:0050879)3.00341085
101prepulse inhibition (GO:0060134)2.99445770
102neuromuscular synaptic transmission (GO:0007274)2.98549315
103positive regulation of dendritic spine morphogenesis (GO:0061003)2.98510245
104neuronal ion channel clustering (GO:0045161)2.98360591
105cell proliferation in forebrain (GO:0021846)2.98148541
106opioid receptor signaling pathway (GO:0038003)2.96479532
107cellular sodium ion homeostasis (GO:0006883)2.96199987
108neurofilament cytoskeleton organization (GO:0060052)2.93094987
109establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.92713004
110mitochondrion transport along microtubule (GO:0047497)2.92713004
111regulation of dendritic spine morphogenesis (GO:0061001)2.91803728
112regulation of synapse structural plasticity (GO:0051823)2.91560605
113primary amino compound metabolic process (GO:1901160)2.89540194
114glycine transport (GO:0015816)2.89268832
115positive regulation of cardiac muscle hypertrophy (GO:0010613)2.88627149
116positive regulation of muscle hypertrophy (GO:0014742)2.88627149
117tryptophan catabolic process (GO:0006569)2.88403140
118indole-containing compound catabolic process (GO:0042436)2.88403140
119indolalkylamine catabolic process (GO:0046218)2.88403140
120negative regulation of hormone metabolic process (GO:0032351)2.87495165
121negative regulation of hormone biosynthetic process (GO:0032353)2.87495165
122forebrain neuron development (GO:0021884)2.86934350
123positive regulation of neurotransmitter transport (GO:0051590)2.86674262
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84615718
125neuron cell-cell adhesion (GO:0007158)2.84481024
126adult walking behavior (GO:0007628)2.83707403
127activation of protein kinase A activity (GO:0034199)2.82392876
128response to morphine (GO:0043278)2.80179883
129neuron recognition (GO:0008038)2.78920891
130mechanosensory behavior (GO:0007638)2.77865154
131regulation of cardiac muscle cell differentiation (GO:2000725)2.76345981
132positive regulation of heart rate (GO:0010460)2.75191283
133cell differentiation involved in kidney development (GO:0061005)2.74652243
134positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.73495595
135membrane depolarization (GO:0051899)2.71326185
136spinal cord development (GO:0021510)2.71232357
137regulation of synaptic plasticity (GO:0048167)2.70562728
138positive regulation of dendritic spine development (GO:0060999)2.69465494
139membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.67471543
140central nervous system projection neuron axonogenesis (GO:0021952)2.66546567
141positive regulation of membrane potential (GO:0045838)2.66186318
142signal complex assembly (GO:0007172)2.66161674
143transmission of nerve impulse (GO:0019226)2.65702828
144negative regulation of microtubule polymerization (GO:0031115)2.65268454
145positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.62153477
146membrane depolarization during action potential (GO:0086010)2.61482481
147pyrimidine nucleobase catabolic process (GO:0006208)2.60568947
148regulation of neurotransmitter secretion (GO:0046928)2.59786373
149long term synaptic depression (GO:0060292)2.58490715
150response to isoquinoline alkaloid (GO:0014072)2.58466850
151establishment of apical/basal cell polarity (GO:0035089)2.55641850
152synapse organization (GO:0050808)2.47451166
153cell communication involved in cardiac conduction (GO:0086065)2.47420667
154dendritic spine organization (GO:0097061)2.45082840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.21365601
2EZH2_22144423_ChIP-Seq_EOC_Human4.07542950
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.84154649
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.54469113
5ERG_21242973_ChIP-ChIP_JURKAT_Human2.68639473
6RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.62321529
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55099966
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55099966
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51637512
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37833831
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.36158427
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.35473318
13* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.32096096
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31235007
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29892213
16DROSHA_22980978_ChIP-Seq_HELA_Human2.27672940
17REST_21632747_ChIP-Seq_MESCs_Mouse2.21918979
18* KDM2B_26808549_Chip-Seq_K562_Human2.13943657
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11133390
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.08790198
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07403141
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07069938
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.06301141
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.05833829
25ZNF274_21170338_ChIP-Seq_K562_Hela2.03538346
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03303664
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01264466
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.00974358
29ZNF263_19887448_ChIP-Seq_K562_Human2.00191970
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00005211
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.7055684
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98221663
33LXR_22292898_ChIP-Seq_THP-1_Human1.97246947
34* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.96465479
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96329257
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.91907244
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90136467
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89495913
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.86922234
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83233703
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.83079022
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82278871
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.79677233
44* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.78047920
45* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74003256
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.73501591
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68664741
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64885306
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61675952
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61675952
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61675952
52KDM2B_26808549_Chip-Seq_DND41_Human1.60214533
53* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.56955386
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.52015086
55* RING1B_27294783_Chip-Seq_NPCs_Mouse1.50264851
56GBX2_23144817_ChIP-Seq_PC3_Human1.49661376
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47331129
58* RING1B_27294783_Chip-Seq_ESCs_Mouse1.42762896
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.42452322
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40802063
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34644444
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33134535
63* KDM2B_26808549_Chip-Seq_JURKAT_Human1.28722069
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.28668080
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27852307
66RNF2_27304074_Chip-Seq_NSC_Mouse1.27645894
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26583071
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24280849
69CTCF_27219007_Chip-Seq_Bcells_Human1.24021077
70NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23497046
71* CREB1_26743006_Chip-Seq_LNCaP_Human1.22842160
72* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22637101
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21271401
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19818215
75IRF1_19129219_ChIP-ChIP_H3396_Human1.18527280
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18197482
77POU5F1_16518401_ChIP-PET_MESCs_Mouse1.18064397
78* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16281214
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15173291
80* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.14812971
81* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14166661
82IGF1R_20145208_ChIP-Seq_DFB_Human1.13513184
83TET1_21490601_ChIP-Seq_MESCs_Mouse1.13081929
84RACK7_27058665_Chip-Seq_MCF-7_Human1.11624618
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10251669
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.09634032
87* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09143707
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08505293
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08412106
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08297254
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06902231
92* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05902855
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04778336
94* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02943806
95SMC4_20622854_ChIP-Seq_HELA_Human1.02438074
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01806864
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01387788
98* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98527828
99P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94618180
100OCT4_19829295_ChIP-Seq_ESCs_Human0.94153495
101ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93305034
102* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92416845
103* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92128885
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91977854
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91576153
106KLF4_19829295_ChIP-Seq_ESCs_Human0.90640716
107* AR_19668381_ChIP-Seq_PC3_Human0.90300700
108* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90163110
109* SA1_27219007_Chip-Seq_ERYTHROID_Human0.89691295
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88944386
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87064409
112* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85842466
113TET1_21451524_ChIP-Seq_MESCs_Mouse0.85389716
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85361195
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85257104
116P68_20966046_ChIP-Seq_HELA_Human0.84554952
117AR_21572438_ChIP-Seq_LNCaP_Human0.84496048
118TP53_16413492_ChIP-PET_HCT116_Human0.80340516
119* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79796302
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.78036780
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78036780
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.77096982
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.76101140
124NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.71349531
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.70407476
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.70364227
127CTBP2_25329375_ChIP-Seq_LNCAP_Human0.66514920
128ZFP57_27257070_Chip-Seq_ESCs_Mouse0.65977625
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.65402352
130SOX3_22085726_ChIP-Seq_NPCs_Mouse0.64475065
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.62028939
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61858699
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.61492216
134EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.61421026
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.61357913
136* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.61212924
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.59320377
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59080570
139NFIB_24661679_ChIP-Seq_LUNG_Mouse0.58911762
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.58842182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.22370342
2MP0003635_abnormal_synaptic_transmissio3.79001312
3MP0009046_muscle_twitch3.66833578
4MP0009745_abnormal_behavioral_response2.83740126
5MP0002063_abnormal_learning/memory/cond2.78851424
6MP0004270_analgesia2.67844011
7MP0003880_abnormal_central_pattern2.61820742
8MP0002064_seizures2.61210695
9MP0004858_abnormal_nervous_system2.58423451
10MP0008569_lethality_at_weaning2.55535858
11MP0002272_abnormal_nervous_system2.35664786
12MP0002572_abnormal_emotion/affect_behav2.32893025
13MP0002184_abnormal_innervation2.28585818
14MP0003283_abnormal_digestive_organ2.19724817
15MP0001968_abnormal_touch/_nociception2.05548304
16MP0001440_abnormal_grooming_behavior2.03820802
17MP0000955_abnormal_spinal_cord1.99428877
18MP0005423_abnormal_somatic_nervous1.95113532
19MP0002067_abnormal_sensory_capabilities1.92300443
20MP0002734_abnormal_mechanical_nocicepti1.91353713
21MP0003329_amyloid_beta_deposits1.85641238
22MP0002653_abnormal_ependyma_morphology1.82111554
23MP0004885_abnormal_endolymph1.80136038
24MP0002138_abnormal_hepatobiliary_system1.75710457
25MP0002909_abnormal_adrenal_gland1.74148598
26MP0002638_abnormal_pupillary_reflex1.73542167
27MP0003123_paternal_imprinting1.73152840
28MP0002733_abnormal_thermal_nociception1.69739695
29MP0000778_abnormal_nervous_system1.69232006
30MP0001486_abnormal_startle_reflex1.65109467
31MP0002736_abnormal_nociception_after1.59893683
32MP0003705_abnormal_hypodermis_morpholog1.59005102
33MP0000372_irregular_coat_pigmentation1.55533082
34MP0005394_taste/olfaction_phenotype1.55372755
35MP0005499_abnormal_olfactory_system1.55372755
36MP0004811_abnormal_neuron_physiology1.55264528
37MP0004142_abnormal_muscle_tone1.52411138
38MP0002822_catalepsy1.52084114
39MP0004272_abnormal_basement_membrane1.50488803
40MP0001529_abnormal_vocalization1.48541611
41MP0001501_abnormal_sleep_pattern1.47142523
42MP0004145_abnormal_muscle_electrophysio1.46016290
43MP0002557_abnormal_social/conspecific_i1.44886408
44MP0002163_abnormal_gland_morphology1.42718555
45MP0000049_abnormal_middle_ear1.41535598
46MP0005646_abnormal_pituitary_gland1.41127262
47MP0001970_abnormal_pain_threshold1.40111993
48MP0005386_behavior/neurological_phenoty1.39816913
49MP0004924_abnormal_behavior1.39816913
50MP0003632_abnormal_nervous_system1.39574376
51MP0004742_abnormal_vestibular_system1.39182071
52MP0002066_abnormal_motor_capabilities/c1.38739301
53MP0001986_abnormal_taste_sensitivity1.36838374
54MP0000631_abnormal_neuroendocrine_gland1.34431838
55MP0005623_abnormal_meninges_morphology1.33260557
56MP0001984_abnormal_olfaction1.31993538
57MP0002152_abnormal_brain_morphology1.30558076
58MP0003121_genomic_imprinting1.30108420
59MP0010234_abnormal_vibrissa_follicle1.29786089
60MP0008872_abnormal_physiological_respon1.29453866
61MP0000639_abnormal_adrenal_gland1.28922046
62MP0004133_heterotaxia1.27141277
63MP0002089_abnormal_postnatal_growth/wei1.26473225
64MP0005645_abnormal_hypothalamus_physiol1.23626482
65MP0002882_abnormal_neuron_morphology1.21976175
66MP0003633_abnormal_nervous_system1.20899590
67MP0004233_abnormal_muscle_weight1.20890913
68MP0009697_abnormal_copulation1.20330182
69MP0005083_abnormal_biliary_tract1.19409439
70MP0010030_abnormal_orbit_morphology1.16942909
71MP0003631_nervous_system_phenotype1.15871967
72MP0002735_abnormal_chemical_nociception1.13853295
73MP0002249_abnormal_larynx_morphology1.13805396
74MP0005360_urolithiasis1.10982280
75MP0003879_abnormal_hair_cell1.06528956
76MP0003861_abnormal_nervous_system1.06267635
77MP0001905_abnormal_dopamine_level1.05544381
78MP0000579_abnormal_nail_morphology1.05497473
79MP0005171_absent_coat_pigmentation1.04699502
80MP0005551_abnormal_eye_electrophysiolog1.02681047
81MP0005085_abnormal_gallbladder_physiolo1.01108618
82MP0003045_fibrosis0.98456945
83MP0003890_abnormal_embryonic-extraembry0.97576433
84MP0001502_abnormal_circadian_rhythm0.97542659
85MP0002139_abnormal_hepatobiliary_system0.97470379
86MP0002282_abnormal_trachea_morphology0.97437091
87MP0005535_abnormal_body_temperature0.96652740
88MP0001485_abnormal_pinna_reflex0.95766906
89MP0005187_abnormal_penis_morphology0.95649512
90MP0002160_abnormal_reproductive_system0.94487194
91MP0008961_abnormal_basal_metabolism0.92927636
92MP0006072_abnormal_retinal_apoptosis0.92375504
93MP0001963_abnormal_hearing_physiology0.92348521
94MP0000462_abnormal_digestive_system0.91216011
95MP0003137_abnormal_impulse_conducting0.90147503
96MP0005379_endocrine/exocrine_gland_phen0.90069133
97MP0001188_hyperpigmentation0.89928525
98MP0005503_abnormal_tendon_morphology0.87781063
99MP0002069_abnormal_eating/drinking_beha0.85551630
100MP0000751_myopathy0.84290783
101MP0003119_abnormal_digestive_system0.83928505
102MP0008874_decreased_physiological_sensi0.81525343
103MP0010769_abnormal_survival0.80167845
104MP0002751_abnormal_autonomic_nervous0.77516798
105MP0001943_abnormal_respiration0.76530899
106MP0009384_cardiac_valve_regurgitation0.75995282
107MP0001348_abnormal_lacrimal_gland0.75661163
108MP0010768_mortality/aging0.75635289
109MP0003787_abnormal_imprinting0.74720134
110MP0004085_abnormal_heartbeat0.74696838
111MP0002098_abnormal_vibrissa_morphology0.74669602
112MP0010329_abnormal_lipoprotein_level0.74149689
113MP0010770_preweaning_lethality0.73708547
114MP0002082_postnatal_lethality0.73708547
115MP0000678_abnormal_parathyroid_gland0.73331000
116MP0003942_abnormal_urinary_system0.73012081
117MP0005408_hypopigmentation0.72880542
118MP0005248_abnormal_Harderian_gland0.72632823
119MP0008789_abnormal_olfactory_epithelium0.72448124
120MP0002081_perinatal_lethality0.72014938
121MP0000026_abnormal_inner_ear0.71937024
122MP0001849_ear_inflammation0.71123632
123MP0002229_neurodegeneration0.70383568
124MP0008877_abnormal_DNA_methylation0.70352048
125MP0009780_abnormal_chondrocyte_physiolo0.70297117
126MP0002116_abnormal_craniofacial_bone0.69517399
127MP0002971_abnormal_brown_adipose0.68510170
128MP0003183_abnormal_peptide_metabolism0.67652108
129MP0002102_abnormal_ear_morphology0.67408313
130MP0008770_decreased_survivor_rate0.67091795
131MP0000604_amyloidosis0.66463792
132MP0006292_abnormal_olfactory_placode0.66451966
133MP0003948_abnormal_gas_homeostasis0.64954243
134MP0003634_abnormal_glial_cell0.62832179
135MP0006276_abnormal_autonomic_nervous0.61983738
136MP0003122_maternal_imprinting0.61735325
137MP0003385_abnormal_body_wall0.60703811
138MP0002752_abnormal_somatic_nervous0.60691566

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.90947929
2Action tremor (HP:0002345)4.81367651
3Progressive cerebellar ataxia (HP:0002073)4.52691013
4Abnormality of the lower motor neuron (HP:0002366)4.48079039
5Visual hallucinations (HP:0002367)4.32901347
6Anomalous pulmonary venous return (HP:0010772)4.17886180
7Annular pancreas (HP:0001734)4.01637146
8Short 4th metacarpal (HP:0010044)4.00025443
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.00025443
10Abnormality of the pulmonary veins (HP:0011718)3.96722958
11Type II lissencephaly (HP:0007260)3.90947712
12Focal motor seizures (HP:0011153)3.82601879
13Focal seizures (HP:0007359)3.80408058
14Dysdiadochokinesis (HP:0002075)3.76862394
15Cerebellar dysplasia (HP:0007033)3.75968305
16Dysmetric saccades (HP:0000641)3.74231311
17Scanning speech (HP:0002168)3.72190285
18Hypothermia (HP:0002045)3.43025705
19Hemiplegia (HP:0002301)3.32866596
20Gaze-evoked nystagmus (HP:0000640)3.31710464
21Down-sloping shoulders (HP:0200021)3.29763707
22Insomnia (HP:0100785)3.25621616
23Impaired smooth pursuit (HP:0007772)3.23233045
24Abnormality of the parietal bone (HP:0002696)3.19117486
25Deformed sella turcica (HP:0002681)3.17573269
26Atonic seizures (HP:0010819)3.17425044
27Genetic anticipation (HP:0003743)3.10682614
28Turricephaly (HP:0000262)3.01700211
29Abnormality of the 4th metacarpal (HP:0010012)3.01386179
30Intention tremor (HP:0002080)2.98014347
31Spinal muscular atrophy (HP:0007269)2.97791639
32Ependymoma (HP:0002888)2.93477227
33Abnormality of ocular smooth pursuit (HP:0000617)2.93385349
34Status epilepticus (HP:0002133)2.88115809
35Dysmetria (HP:0001310)2.88013903
36Pendular nystagmus (HP:0012043)2.86418164
37Astrocytoma (HP:0009592)2.83822368
38Abnormality of the astrocytes (HP:0100707)2.83822368
39Supernumerary ribs (HP:0005815)2.81801837
40Hemiparesis (HP:0001269)2.79445913
41Hyperacusis (HP:0010780)2.74725565
42Vitreoretinal degeneration (HP:0000655)2.74172628
43Supernumerary bones of the axial skeleton (HP:0009144)2.69661159
44Febrile seizures (HP:0002373)2.66419752
45Vertebral fusion (HP:0002948)2.64338915
46Broad ribs (HP:0000885)2.63850166
47Epileptic encephalopathy (HP:0200134)2.61343834
48Absence seizures (HP:0002121)2.59808364
49Renovascular hypertension (HP:0100817)2.58776378
50Broad-based gait (HP:0002136)2.55560007
51Shallow orbits (HP:0000586)2.51915934
52Posterior subcapsular cataract (HP:0007787)2.51238822
53Macroglossia (HP:0000158)2.51126805
54Elfin facies (HP:0004428)2.49074420
55Limb dystonia (HP:0002451)2.48089313
56Hemivertebrae (HP:0002937)2.48010243
57Neoplasm of the oral cavity (HP:0100649)2.47014203
58Depression (HP:0000716)2.45995561
59Stereotypic behavior (HP:0000733)2.43092909
60Short phalanx of the thumb (HP:0009660)2.42896790
61Horizontal nystagmus (HP:0000666)2.42582868
62Amblyopia (HP:0000646)2.42580328
63Pointed chin (HP:0000307)2.40799043
64Abnormality of the sella turcica (HP:0002679)2.38767800
65Renal duplication (HP:0000075)2.33329170
66Overriding aorta (HP:0002623)2.32951006
67Coronal craniosynostosis (HP:0004440)2.30701351
68Abnormality of the diencephalon (HP:0010662)2.30174304
69Meningocele (HP:0002435)2.29009531
70Bowel diverticulosis (HP:0005222)2.28865756
71Lissencephaly (HP:0001339)2.25348507
72Truncal ataxia (HP:0002078)2.24847656
73Tetraplegia (HP:0002445)2.24636194
74Urinary bladder sphincter dysfunction (HP:0002839)2.23344934
75Postural tremor (HP:0002174)2.23191870
76Broad alveolar ridges (HP:0000187)2.21961303
77Impaired social interactions (HP:0000735)2.21902427
78Abnormal social behavior (HP:0012433)2.21902427
79Generalized tonic-clonic seizures (HP:0002069)2.21898324
80Amyotrophic lateral sclerosis (HP:0007354)2.21696926
81Abnormality of the Achilles tendon (HP:0005109)2.20602181
82Glioma (HP:0009733)2.19236226
83Drooling (HP:0002307)2.18111608
84Neoplasm of the heart (HP:0100544)2.17608624
85Achilles tendon contracture (HP:0001771)2.17414219
86Polyphagia (HP:0002591)2.16592546
87Diastasis recti (HP:0001540)2.14551937
88Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.13946330
89Poor eye contact (HP:0000817)2.13630300
90Dialeptic seizures (HP:0011146)2.13297035
91Hypoplasia of the brainstem (HP:0002365)2.11350978
92Aplasia/Hypoplasia of the brainstem (HP:0007362)2.11350978
93Pachygyria (HP:0001302)2.10183209
94Anxiety (HP:0000739)2.09486101
95Spastic gait (HP:0002064)2.08552810
96Cerebral aneurysm (HP:0004944)2.08162338
97Protruding tongue (HP:0010808)2.08112317
98Renal tubular acidosis (HP:0001947)2.06802959
99Obstructive sleep apnea (HP:0002870)2.06244768
100Limb ataxia (HP:0002070)2.05594097
101Septo-optic dysplasia (HP:0100842)2.05477286
102Abnormal eating behavior (HP:0100738)2.03606136
103Hand muscle atrophy (HP:0009130)2.03452571
104Severe muscular hypotonia (HP:0006829)2.02996713
105Hyperventilation (HP:0002883)1.97917953
106Morphological abnormality of the pyramidal tract (HP:0002062)1.97888224
107Myelomeningocele (HP:0002475)1.97505119
108Distal upper limb amyotrophy (HP:0007149)1.97332056
109Upper limb amyotrophy (HP:0009129)1.97332056
110Supranuclear gaze palsy (HP:0000605)1.96451710
111Malignant neoplasm of the central nervous system (HP:0100836)1.95341586
112Abolished electroretinogram (ERG) (HP:0000550)1.95025013
113Bronchomalacia (HP:0002780)1.94354815
114Rib fusion (HP:0000902)1.94195187
115Back pain (HP:0003418)1.93792196
116Excessive salivation (HP:0003781)1.93049443
117Hypochromic microcytic anemia (HP:0004840)1.91191444
118Death in childhood (HP:0003819)1.90907676
119Shawl scrotum (HP:0000049)1.90820046
120Neuroectodermal neoplasm (HP:0030061)1.88082733
121Neuroepithelial neoplasm (HP:0030063)1.88082733
122Nervous tissue neoplasm (HP:0030060)1.88082733
123Pseudobulbar signs (HP:0002200)1.83564737
124Arnold-Chiari malformation (HP:0002308)1.83131725
125Ventricular fibrillation (HP:0001663)1.82383049
126Unsteady gait (HP:0002317)1.82102722
127Cerebral hypomyelination (HP:0006808)1.81647084
128Impaired vibration sensation in the lower limbs (HP:0002166)1.81207120
129Abnormality of binocular vision (HP:0011514)1.80863912
130Diplopia (HP:0000651)1.80863912
131Bladder diverticulum (HP:0000015)1.80718581
132Cerebral inclusion bodies (HP:0100314)1.80487644
133Calf muscle hypertrophy (HP:0008981)1.80144916
134Agitation (HP:0000713)1.79015468
135Keratoconus (HP:0000563)1.78929812
136Increased corneal curvature (HP:0100692)1.78929812
137Deep venous thrombosis (HP:0002625)1.78659862
138Abnormality of the intervertebral disk (HP:0005108)1.78079822
139Hypoplasia of the pons (HP:0012110)1.76921199
140Neuronal loss in central nervous system (HP:0002529)1.76106569
141Lower limb asymmetry (HP:0100559)1.76004275
142Abnormal pancreas size (HP:0012094)1.74795891
143Oral leukoplakia (HP:0002745)1.74358257
144Postural instability (HP:0002172)1.74023945
145Medulloblastoma (HP:0002885)1.73319602
146Broad metatarsal (HP:0001783)1.71822012
147Abnormality of the corticospinal tract (HP:0002492)1.71299212
148Hypoventilation (HP:0002791)1.71038783
149Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70976285
150Flat cornea (HP:0007720)1.69819479
151Hypoplastic nipples (HP:0002557)1.69801101
152Neurofibrillary tangles (HP:0002185)1.68665110
153Mutism (HP:0002300)1.67948220
154Sleep apnea (HP:0010535)1.67781022
155Abnormality of the odontoid process (HP:0003310)1.67467222
156Skin pits (HP:0100276)1.66323964
157Absent speech (HP:0001344)1.65789531
158Neuroblastoma (HP:0003006)1.64477151
159Primitive neuroectodermal tumor (HP:0030065)1.64477151
160Neuroblastic tumors (HP:0004376)1.64477151
161Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.64477151
162Hypercortisolism (HP:0001578)1.64318971
163Aqueductal stenosis (HP:0002410)1.63573973
164Torticollis (HP:0000473)1.63007676
165Abnormality of saccadic eye movements (HP:0000570)1.61860440
166Gait ataxia (HP:0002066)1.59933642

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.38694381
2MAP3K104.06105834
3CASK2.39617901
4MAP3K92.38136212
5EPHA32.30747150
6ADRBK22.19931467
7EPHA42.10195330
8NTRK32.08647748
9MATK2.04728958
10CDK1910.1505006
11TYRO31.92179374
12VRK11.86858599
13RIPK11.83937795
14MAP2K41.83603541
15DAPK21.72279553
16ICK1.66100096
17SGK2231.64237800
18SGK4941.64237800
19MAP3K111.63879598
20PKN11.62090326
21PAK61.60083357
22DDR21.59434517
23DYRK21.57432948
24STK381.53906038
25CAMKK11.52964200
26MAP3K41.49758867
27TRIB31.48325291
28LATS21.43931869
29MINK11.37689599
30MARK11.35163705
31CAMKK21.30625950
32NTRK11.30130898
33PRKD31.27536228
34EPHB21.26109667
35NTRK21.25229087
36CDK11A1.24899478
37SGK21.24203108
38RPS6KA51.17294018
39ALK1.14438283
40UHMK11.13245107
41KSR21.12650277
42DAPK11.09649910
43WNK31.09348380
44PDGFRA1.07497321
45BMX1.06676267
46KSR11.06144180
47SIK21.04990196
48EEF2K1.01242410
49TLK10.97860301
50PIM20.93758756
51SIK10.92355289
52PRKCI0.88834021
53AURKA0.88666836
54GRK70.87796002
55GRK50.86618716
56WNK10.86282619
57PRKCH0.85267518
58CDK150.85026831
59PRKAA10.84125499
60PHKG20.81261595
61PHKG10.81261595
62INSRR0.81171922
63CDK180.80307192
64CDK50.79691397
65PRKD20.76974465
66PRKCG0.76577390
67GRK10.75584238
68STK40.75445067
69MAP3K60.74570253
70DYRK30.73606157
71PRPF4B0.69044143
72PINK10.67388853
73ERBB20.67082664
74CDK140.66749447
75RPS6KA20.66556387
76STK110.64933844
77TNIK0.63679065
78MAPK120.63082706
79BRAF0.61930425
80PRKCE0.60642851
81RET0.60365910
82PRKCQ0.60303062
83RIPK40.60277407
84AKT30.59961209
85PTK60.59053046
86CAMK40.58181525
87PKN20.57951322
88TAOK10.57631753
89PTK20.57085967
90PIM10.56795539
91BRD40.56488435
92MAP2K70.55132465
93CSNK1A1L0.53471853
94MAP2K30.53428615
95CSNK1G30.52686106
96MAP2K60.48906626
97CDC42BPA0.45833853
98DYRK1B0.45385362
99CAMK1D0.42698282
100CAMK10.42410077
101BRSK10.41328948
102CAMK2A0.39865148
103PRKACA0.39173432
104DYRK1A0.38145576
105CSNK1G10.37985067
106WNK40.37363546
107FGR0.37325799
108CDK60.37016773
109FGFR20.36504293
110MARK20.36371345
111MAPK90.36159283
112CSNK1E0.35129262
113RPS6KA60.35018774
114PNCK0.34859368
115DAPK30.34757061
116RPS6KA30.34276986
117TAF10.34266812
118FER0.34173463
119LATS10.33943321
120BMPR1B0.33471305
121MUSK0.33376938
122GRK60.33340800
123NEK10.33328560
124PRKCZ0.32575539
125MAPK130.31751413
126MTOR0.30482250
127MAPK100.30129263
128MAPK80.29703916
129CSNK1G20.27991586
130CAMK2B0.27434190
131PAK30.27180717
132CDK40.26201187
133HIPK20.25979151
134CAMK2G0.25902608
135SGK30.25883496
136PRKACG0.25778704
137CDK120.24854489
138SGK10.24733912
139MAP2K10.24129590
140FGFR10.23689721
141PRKDC0.23312895

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.39005724
2Alcoholism_Homo sapiens_hsa050344.81680435
3Nicotine addiction_Homo sapiens_hsa050333.32721990
4Glutamatergic synapse_Homo sapiens_hsa047242.52626513
5Synaptic vesicle cycle_Homo sapiens_hsa047212.48848835
6Long-term potentiation_Homo sapiens_hsa047202.43926098
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.41301624
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22016132
9Long-term depression_Homo sapiens_hsa047302.21511176
10Nitrogen metabolism_Homo sapiens_hsa009102.16150804
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15020700
12GABAergic synapse_Homo sapiens_hsa047272.11098247
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.09540620
14Circadian entrainment_Homo sapiens_hsa047132.07163750
15Amphetamine addiction_Homo sapiens_hsa050311.98668386
16Salivary secretion_Homo sapiens_hsa049701.96126630
17Morphine addiction_Homo sapiens_hsa050321.67736142
18Dopaminergic synapse_Homo sapiens_hsa047281.66576966
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64620617
20Arginine biosynthesis_Homo sapiens_hsa002201.62492436
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61469528
22Viral carcinogenesis_Homo sapiens_hsa052031.60635142
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57761585
24Taste transduction_Homo sapiens_hsa047421.55358340
25Gastric acid secretion_Homo sapiens_hsa049711.50078897
26Olfactory transduction_Homo sapiens_hsa047401.48079300
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41672814
28GnRH signaling pathway_Homo sapiens_hsa049121.39615428
29Bile secretion_Homo sapiens_hsa049761.39234595
30Selenocompound metabolism_Homo sapiens_hsa004501.38667332
31Oxytocin signaling pathway_Homo sapiens_hsa049211.30946508
32Gap junction_Homo sapiens_hsa045401.30754730
33Fatty acid biosynthesis_Homo sapiens_hsa000611.29282749
34Insulin secretion_Homo sapiens_hsa049111.28703918
35Cholinergic synapse_Homo sapiens_hsa047251.26491594
36African trypanosomiasis_Homo sapiens_hsa051431.25256077
37Estrogen signaling pathway_Homo sapiens_hsa049151.19811583
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17312945
39Renin secretion_Homo sapiens_hsa049241.16041990
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14951886
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14720636
42Renin-angiotensin system_Homo sapiens_hsa046141.12560025
43Phototransduction_Homo sapiens_hsa047441.11704622
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11454563
45Tryptophan metabolism_Homo sapiens_hsa003801.10926323
46Calcium signaling pathway_Homo sapiens_hsa040201.08628486
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08308743
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08167480
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06295235
50Cocaine addiction_Homo sapiens_hsa050301.02069100
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98517583
52Glioma_Homo sapiens_hsa052140.96853485
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95827890
54Melanogenesis_Homo sapiens_hsa049160.95670020
55mTOR signaling pathway_Homo sapiens_hsa041500.95417820
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.91320911
57Oocyte meiosis_Homo sapiens_hsa041140.89500503
58Type II diabetes mellitus_Homo sapiens_hsa049300.89381368
59cAMP signaling pathway_Homo sapiens_hsa040240.89355435
60Thyroid hormone synthesis_Homo sapiens_hsa049180.88184325
61VEGF signaling pathway_Homo sapiens_hsa043700.86104111
62ErbB signaling pathway_Homo sapiens_hsa040120.85902928
63Hedgehog signaling pathway_Homo sapiens_hsa043400.83776868
64Mineral absorption_Homo sapiens_hsa049780.82201984
65Axon guidance_Homo sapiens_hsa043600.80757295
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.80511710
67Serotonergic synapse_Homo sapiens_hsa047260.79837134
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79246512
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78186383
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77496509
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75517254
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74800533
73Choline metabolism in cancer_Homo sapiens_hsa052310.71936572
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70372030
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.69593755
76Lysine degradation_Homo sapiens_hsa003100.69429986
77Non-small cell lung cancer_Homo sapiens_hsa052230.68696954
78Glucagon signaling pathway_Homo sapiens_hsa049220.65199914
79MAPK signaling pathway_Homo sapiens_hsa040100.64562294
80Hippo signaling pathway_Homo sapiens_hsa043900.64178834
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63822598
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63660831
83Endometrial cancer_Homo sapiens_hsa052130.63636601
84Basal cell carcinoma_Homo sapiens_hsa052170.63069160
85Biosynthesis of amino acids_Homo sapiens_hsa012300.62873256
86Pancreatic secretion_Homo sapiens_hsa049720.62517016
87beta-Alanine metabolism_Homo sapiens_hsa004100.62303215
88Wnt signaling pathway_Homo sapiens_hsa043100.61858765
89Dorso-ventral axis formation_Homo sapiens_hsa043200.61435352
90Circadian rhythm_Homo sapiens_hsa047100.58401582
91Cardiac muscle contraction_Homo sapiens_hsa042600.58383677
92Ras signaling pathway_Homo sapiens_hsa040140.58014982
93Bladder cancer_Homo sapiens_hsa052190.57788704
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57705694
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56345257
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53732116
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51911828
98Proteoglycans in cancer_Homo sapiens_hsa052050.48514560
99Prion diseases_Homo sapiens_hsa050200.47420715
100Dilated cardiomyopathy_Homo sapiens_hsa054140.47076536
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46020048
102Collecting duct acid secretion_Homo sapiens_hsa049660.45740027
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.45436035
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45101697
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.44468891
106Rap1 signaling pathway_Homo sapiens_hsa040150.44404582
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43993184
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43726525
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42504971
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42394850
111Ovarian steroidogenesis_Homo sapiens_hsa049130.42336216
112Sulfur relay system_Homo sapiens_hsa041220.40785432
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.40766681
114Butanoate metabolism_Homo sapiens_hsa006500.40362212
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.38973183
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38320053
117AMPK signaling pathway_Homo sapiens_hsa041520.38307844
118Melanoma_Homo sapiens_hsa052180.37925177
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.35633721
120Prolactin signaling pathway_Homo sapiens_hsa049170.34447750
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33520019
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32613184
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31529932
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31454471
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28024057
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27434448
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26920065
128Steroid biosynthesis_Homo sapiens_hsa001000.25226126
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.23147893
130Arginine and proline metabolism_Homo sapiens_hsa003300.20063820

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