SHFM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.90734377
2energy coupled proton transport, down electrochemical gradient (GO:0015985)7.68730554
3ATP synthesis coupled proton transport (GO:0015986)7.68730554
4ribosomal small subunit biogenesis (GO:0042274)7.63868900
5viral transcription (GO:0019083)7.55344633
6translational termination (GO:0006415)7.20155319
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.78035635
8cotranslational protein targeting to membrane (GO:0006613)6.59933258
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.56177795
10protein targeting to ER (GO:0045047)6.52775940
11ribosomal small subunit assembly (GO:0000028)6.27493212
12establishment of protein localization to endoplasmic reticulum (GO:0072599)6.26128928
13protein localization to endoplasmic reticulum (GO:0070972)6.15517200
14respiratory electron transport chain (GO:0022904)6.01097574
15electron transport chain (GO:0022900)5.85769387
16translational elongation (GO:0006414)5.75525174
17viral life cycle (GO:0019058)5.72334080
18cellular protein complex disassembly (GO:0043624)5.64082826
19protein neddylation (GO:0045116)5.30057610
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.12574135
21GTP biosynthetic process (GO:0006183)5.00286481
22translational initiation (GO:0006413)4.87945643
23maturation of SSU-rRNA (GO:0030490)4.85706046
24ribosomal large subunit biogenesis (GO:0042273)4.65535482
25protein complex disassembly (GO:0043241)4.62334115
26macromolecular complex disassembly (GO:0032984)4.36162404
27protein targeting to membrane (GO:0006612)4.35931165
28translation (GO:0006412)4.32000346
29establishment of protein localization to mitochondrial membrane (GO:0090151)4.24159206
30chaperone-mediated protein transport (GO:0072321)4.20026043
31UTP biosynthetic process (GO:0006228)4.19916388
32regulation of mitochondrial translation (GO:0070129)4.07842196
33proteasome assembly (GO:0043248)3.93872551
34purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.82312324
35chromatin remodeling at centromere (GO:0031055)3.80465847
36CENP-A containing nucleosome assembly (GO:0034080)3.78693080
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78419527
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.78419527
39NADH dehydrogenase complex assembly (GO:0010257)3.78419527
40protein complex biogenesis (GO:0070271)3.76072506
41purine nucleoside triphosphate biosynthetic process (GO:0009145)3.70008012
42spliceosomal snRNP assembly (GO:0000387)3.65310924
43termination of RNA polymerase III transcription (GO:0006386)3.61659863
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.61659863
45hydrogen ion transmembrane transport (GO:1902600)3.55978438
46oxidative phosphorylation (GO:0006119)3.54905762
47UTP metabolic process (GO:0046051)3.53151000
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.52136242
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49759572
50ATP biosynthetic process (GO:0006754)3.48605422
51central nervous system myelination (GO:0022010)3.45665711
52axon ensheathment in central nervous system (GO:0032291)3.45665711
53spliceosomal complex assembly (GO:0000245)3.44213017
54nuclear-transcribed mRNA catabolic process (GO:0000956)3.43378875
55rRNA modification (GO:0000154)3.38997616
56guanosine-containing compound biosynthetic process (GO:1901070)3.38987222
57antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.38680090
58CTP metabolic process (GO:0046036)3.33694814
59CTP biosynthetic process (GO:0006241)3.33694814
60mitochondrial respiratory chain complex assembly (GO:0033108)3.31655501
61ribonucleoside triphosphate biosynthetic process (GO:0009201)3.29782652
62mRNA catabolic process (GO:0006402)3.25696537
63nucleoside diphosphate phosphorylation (GO:0006165)3.19852576
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18381157
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18381157
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18062819
67proton transport (GO:0015992)3.17996415
68DNA damage response, detection of DNA damage (GO:0042769)3.17721026
69regulation of cellular amino acid metabolic process (GO:0006521)3.17535582
70sequestering of actin monomers (GO:0042989)3.16962053
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14128448
72intracellular protein transmembrane import (GO:0044743)3.13396301
73histone exchange (GO:0043486)3.10634803
74hydrogen transport (GO:0006818)3.08500217
75establishment of protein localization to membrane (GO:0090150)3.08236234
76purine nucleoside monophosphate biosynthetic process (GO:0009127)3.06017436
77purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.06017436
78DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.05901760
79neutrophil activation involved in immune response (GO:0002283)3.04881994
807-methylguanosine mRNA capping (GO:0006370)3.03283603
81RNA capping (GO:0036260)3.02098717
827-methylguanosine RNA capping (GO:0009452)3.02098717
83mitochondrial transport (GO:0006839)3.01924690
84rRNA processing (GO:0006364)3.00751750
85negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00395826
86negative regulation of ligase activity (GO:0051352)3.00395826
87positive regulation of ligase activity (GO:0051351)2.99744463
88intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96249949
89signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96249949
90histone mRNA metabolic process (GO:0008334)2.94805540
91protein targeting (GO:0006605)2.93658419
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91877309
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91877309
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91877309
95rRNA metabolic process (GO:0016072)2.89922181
96protein-cofactor linkage (GO:0018065)2.89618829
97ribonucleoprotein complex biogenesis (GO:0022613)2.86687656
98establishment of viral latency (GO:0019043)2.86154689
99pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.85862857
100protein targeting to mitochondrion (GO:0006626)2.85776259
101signal transduction involved in DNA integrity checkpoint (GO:0072401)2.84443606
102signal transduction involved in DNA damage checkpoint (GO:0072422)2.84443606
103establishment of integrated proviral latency (GO:0075713)2.84093254
104respiratory chain complex IV assembly (GO:0008535)2.84059280
105RNA catabolic process (GO:0006401)2.83405786
106nucleoside triphosphate biosynthetic process (GO:0009142)2.82901274
107signal transduction involved in cell cycle checkpoint (GO:0072395)2.81964428
108positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79487513
109long-chain fatty acid biosynthetic process (GO:0042759)2.79014224
110cellular component biogenesis (GO:0044085)2.78580012
111establishment of protein localization to mitochondrion (GO:0072655)2.77966597
112pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.77619922
113inner mitochondrial membrane organization (GO:0007007)2.71438034
114substantia nigra development (GO:0021762)2.70104541
115nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68238681
116fatty acid elongation (GO:0030497)2.68172974
117cytochrome complex assembly (GO:0017004)2.63338264
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61430483
119peptidyl-histidine modification (GO:0018202)2.60631407
120antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.58702617
121establishment of protein localization to organelle (GO:0072594)2.58142643
122protein localization to mitochondrion (GO:0070585)2.55451825
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54698327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.96112560
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.44830836
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43637945
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.38766412
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.75855732
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.57786852
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.56172261
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.15660308
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04576939
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96114922
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.88038166
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85312129
13ELK1_19687146_ChIP-ChIP_HELA_Human2.67325852
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.67204235
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.61189670
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52073023
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32592877
18CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.13707409
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08932194
20VDR_22108803_ChIP-Seq_LS180_Human2.06816433
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04862886
22ELK1_22589737_ChIP-Seq_MCF10A_Human2.01874042
23VDR_23849224_ChIP-Seq_CD4+_Human2.01418326
24E2F7_22180533_ChIP-Seq_HELA_Human1.99546034
25DCP1A_22483619_ChIP-Seq_HELA_Human1.98990915
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86882848
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.84788477
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84577424
29TTF2_22483619_ChIP-Seq_HELA_Human1.78566795
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75830415
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73347458
32XRN2_22483619_ChIP-Seq_HELA_Human1.72286250
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59767936
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55106813
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53212749
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49004325
37ZNF274_21170338_ChIP-Seq_K562_Hela1.48233025
38MYC_18940864_ChIP-ChIP_HL60_Human1.45649991
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.45108207
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43801970
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39851760
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38062328
43NANOG_16153702_ChIP-ChIP_HESCs_Human1.34485528
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.33453304
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32787817
46FOXP3_21729870_ChIP-Seq_TREG_Human1.31625196
47* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30977310
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30159094
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.28739701
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.27681916
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.27661375
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22494939
53FUS_26573619_Chip-Seq_HEK293_Human1.21290541
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21203779
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20326897
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17190901
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16786889
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.16469733
59TAF15_26573619_Chip-Seq_HEK293_Human1.15078973
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15013226
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14727979
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.14066229
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13716768
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12697396
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12604035
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.10845062
67* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09303245
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08685304
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07567833
70* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07018791
71SOX17_20123909_ChIP-Seq_XEN_Mouse1.07015677
72P300_19829295_ChIP-Seq_ESCs_Human1.06452776
73* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06109517
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04010095
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03334174
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03215929
77* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01971388
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00662922
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.00073635
80TP53_22573176_ChIP-Seq_HFKS_Human0.99623234
81IRF1_19129219_ChIP-ChIP_H3396_Human0.98120743
82PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96255069
83MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96035615
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95834916
85STAT1_20625510_ChIP-Seq_HELA_Human0.95082140
86NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94448323
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94443362
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92531726
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92062922
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91820755
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91740340
92AR_21909140_ChIP-Seq_LNCAP_Human0.91548831
93* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90308246
94* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89186415
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88886709
96* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88337957
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87703124
98NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87327112
99ERG_20517297_ChIP-Seq_VCAP_Human0.86702115
100FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.86697776
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86232814
102IGF1R_20145208_ChIP-Seq_DFB_Human0.84860933
103* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84752092
104FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84299505
105FOXA1_25329375_ChIP-Seq_VCAP_Human0.84299505
106SPI1_23547873_ChIP-Seq_NB4_Human0.83887470
107EWS_26573619_Chip-Seq_HEK293_Human0.83498028
108* ER_23166858_ChIP-Seq_MCF-7_Human0.83414417
109E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82596920
110AR_20517297_ChIP-Seq_VCAP_Human0.82193312
111RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81997010
112NANOG_19829295_ChIP-Seq_ESCs_Human0.81588878
113SOX2_19829295_ChIP-Seq_ESCs_Human0.81588878
114EZH2_27304074_Chip-Seq_ESCs_Mouse0.81517932
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.78661749
116SALL1_21062744_ChIP-ChIP_HESCs_Human0.78217445
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77926256
118GABP_19822575_ChIP-Seq_HepG2_Human0.76825307
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.76485637
120HTT_18923047_ChIP-ChIP_STHdh_Human0.76396891
121STAT4_19710469_ChIP-ChIP_TH1__Mouse0.75947267
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75669015
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75422128
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74836541
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74357451
126* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.74100753
127EED_16625203_ChIP-ChIP_MESCs_Mouse0.73596943
128RNF2_27304074_Chip-Seq_NSC_Mouse0.71341181
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.71147411
130PCGF2_27294783_Chip-Seq_NPCs_Mouse0.70003359
131* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.69722659
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.69495803
133NANOG_20526341_ChIP-Seq_ESCs_Human0.69021234
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.68362323
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67855628
136ETV2_25802403_ChIP-Seq_MESCs_Mouse0.67560406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.98751678
2MP0003136_yellow_coat_color4.69192750
3MP0006292_abnormal_olfactory_placode3.80872787
4MP0004381_abnormal_hair_follicle3.21145055
5MP0000372_irregular_coat_pigmentation2.66658604
6MP0001905_abnormal_dopamine_level2.62522446
7MP0002148_abnormal_hypersensitivity_rea2.53995266
8MP0010030_abnormal_orbit_morphology2.48436086
9MP0003806_abnormal_nucleotide_metabolis2.45542470
10MP0005171_absent_coat_pigmentation2.44331140
11MP0001529_abnormal_vocalization2.42714113
12MP0008058_abnormal_DNA_repair2.39137517
13MP0003724_increased_susceptibility_to2.32410933
14MP0005408_hypopigmentation2.28323763
15MP0005409_darkened_coat_color2.20375215
16MP0002638_abnormal_pupillary_reflex2.17796048
17MP0001293_anophthalmia2.10287231
18MP0003693_abnormal_embryo_hatching2.06851551
19MP0002938_white_spotting2.03369345
20MP0001727_abnormal_embryo_implantation2.01180813
21MP0009697_abnormal_copulation1.92837809
22MP0010094_abnormal_chromosome_stability1.90836133
23MP0009785_altered_susceptibility_to1.88151773
24MP0002277_abnormal_respiratory_mucosa1.87103321
25MP0002102_abnormal_ear_morphology1.83343338
26MP0000920_abnormal_myelination1.81085749
27MP0002163_abnormal_gland_morphology1.74178961
28MP0004742_abnormal_vestibular_system1.69565084
29MP0003880_abnormal_central_pattern1.68016770
30MP0002837_dystrophic_cardiac_calcinosis1.60069982
31MP0006276_abnormal_autonomic_nervous1.55286813
32MP0008877_abnormal_DNA_methylation1.51357072
33MP0005451_abnormal_body_composition1.50989849
34MP0003186_abnormal_redox_activity1.46515102
35MP0004133_heterotaxia1.46445375
36MP0005000_abnormal_immune_tolerance1.46181976
37MP0003890_abnormal_embryonic-extraembry1.45740057
38MP0000631_abnormal_neuroendocrine_gland1.45600095
39MP0003077_abnormal_cell_cycle1.45111744
40MP0008932_abnormal_embryonic_tissue1.44071620
41MP0003195_calcinosis1.42273205
42MP0005379_endocrine/exocrine_gland_phen1.41609740
43MP0005025_abnormal_response_to1.35730123
44MP0001485_abnormal_pinna_reflex1.34885130
45MP0001542_abnormal_bone_strength1.30889631
46MP0001346_abnormal_lacrimal_gland1.29013562
47MP0003938_abnormal_ear_development1.28672027
48MP0006035_abnormal_mitochondrial_morpho1.28221051
49MP0001986_abnormal_taste_sensitivity1.27871465
50MP0001188_hyperpigmentation1.27399073
51MP0002419_abnormal_innate_immunity1.25814443
52MP0001984_abnormal_olfaction1.25384863
53MP0001286_abnormal_eye_development1.24457474
54MP0009333_abnormal_splenocyte_physiolog1.24418858
55MP0003111_abnormal_nucleus_morphology1.22616153
56MP0003567_abnormal_fetal_cardiomyocyte1.21788191
57MP0001835_abnormal_antigen_presentation1.20191934
58MP0003436_decreased_susceptibility_to1.18348403
59MP0005551_abnormal_eye_electrophysiolog1.17813052
60MP0000762_abnormal_tongue_morphology1.16180560
61MP0010386_abnormal_urinary_bladder1.15268100
62MP0002282_abnormal_trachea_morphology1.14858245
63MP0003718_maternal_effect1.13236346
64MP0005499_abnormal_olfactory_system1.12077496
65MP0005394_taste/olfaction_phenotype1.12077496
66MP0004142_abnormal_muscle_tone1.11884405
67MP0002233_abnormal_nose_morphology1.11394392
68MP0002653_abnormal_ependyma_morphology1.11328089
69MP0002295_abnormal_pulmonary_circulatio1.11325411
70MP0002697_abnormal_eye_size1.09429023
71MP0003011_delayed_dark_adaptation1.08390359
72MP0001851_eye_inflammation1.08171111
73MP0002234_abnormal_pharynx_morphology1.07717949
74MP0008875_abnormal_xenobiotic_pharmacok1.07545740
75MP0002796_impaired_skin_barrier1.07406762
76MP0003941_abnormal_skin_development1.06324922
77MP0002751_abnormal_autonomic_nervous1.04714187
78MP0002132_abnormal_respiratory_system1.04439146
79MP0004272_abnormal_basement_membrane1.02733330
80MP0005174_abnormal_tail_pigmentation1.02453997
81MP0003121_genomic_imprinting1.01971306
82MP0003283_abnormal_digestive_organ1.01608471
83MP0006036_abnormal_mitochondrial_physio1.00963138
84MP0000049_abnormal_middle_ear1.00465396
85MP0002210_abnormal_sex_determination0.99877733
86MP0005164_abnormal_response_to0.98551455
87MP0003950_abnormal_plasma_membrane0.98230556
88MP0002090_abnormal_vision0.97861756
89MP0008872_abnormal_physiological_respon0.97400145
90MP0006082_CNS_inflammation0.95314313
91MP0005391_vision/eye_phenotype0.94708323
92MP0004147_increased_porphyrin_level0.94365148
93MP0001968_abnormal_touch/_nociception0.92599323
94MP0002095_abnormal_skin_pigmentation0.92568658
95MP0008004_abnormal_stomach_pH0.92465959
96MP0002098_abnormal_vibrissa_morphology0.91655987
97MP0003315_abnormal_perineum_morphology0.90285941
98MP0009250_abnormal_appendicular_skeleto0.89918610
99MP0003878_abnormal_ear_physiology0.89140345
100MP0005377_hearing/vestibular/ear_phenot0.89140345
101MP0001764_abnormal_homeostasis0.88381703
102MP0001879_abnormal_lymphatic_vessel0.87742377
103MP0000647_abnormal_sebaceous_gland0.87335005
104MP0006072_abnormal_retinal_apoptosis0.86185610
105MP0008007_abnormal_cellular_replicative0.85038577
106MP0000026_abnormal_inner_ear0.84831485
107MP0002405_respiratory_system_inflammati0.84363569
108MP0000343_altered_response_to0.84292843
109MP0002723_abnormal_immune_serum0.83923763
110MP0002452_abnormal_antigen_presenting0.82703900
111MP0004019_abnormal_vitamin_homeostasis0.82553663
112MP0000383_abnormal_hair_follicle0.82405863
113MP0009046_muscle_twitch0.82196989
114MP0002160_abnormal_reproductive_system0.82175662
115MP0000750_abnormal_muscle_regeneration0.81875981
116MP0008438_abnormal_cutaneous_collagen0.81572799
117MP0005195_abnormal_posterior_eye0.80968037
118MP0003119_abnormal_digestive_system0.79866205
119MP0001440_abnormal_grooming_behavior0.79513256
120MP0005275_abnormal_skin_tensile0.79499124
121MP0001145_abnormal_male_reproductive0.79160825
122MP0000653_abnormal_sex_gland0.79057411
123MP0001929_abnormal_gametogenesis0.78819273
124MP0008057_abnormal_DNA_replication0.78044882
125MP0001853_heart_inflammation0.77825518
126MP0003786_premature_aging0.76757708
127MP0005075_abnormal_melanosome_morpholog0.76617938
128MP0002420_abnormal_adaptive_immunity0.76382227
129MP0004957_abnormal_blastocyst_morpholog0.75761339
130MP0003123_paternal_imprinting0.75409812
131MP0001819_abnormal_immune_cell0.75346262
132MP0005671_abnormal_response_to0.74985215
133MP0005389_reproductive_system_phenotype0.74848589
134MP0005646_abnormal_pituitary_gland0.74830103
135MP0000566_synostosis0.74445518
136MP0005084_abnormal_gallbladder_morpholo0.73753996
137MP0002177_abnormal_outer_ear0.73397114
138MP0000579_abnormal_nail_morphology0.73050891
139MP0001533_abnormal_skeleton_physiology0.71570021
140MP0008789_abnormal_olfactory_epithelium0.71251600
141MP0000538_abnormal_urinary_bladder0.71109605
142MP0003122_maternal_imprinting0.70530995
143MP0003828_pulmonary_edema0.70112257
144MP0001324_abnormal_eye_pigmentation0.69722109
145MP0003755_abnormal_palate_morphology0.67815615
146MP0001919_abnormal_reproductive_system0.67752498
147MP0002111_abnormal_tail_morphology0.67355240
148MP0003385_abnormal_body_wall0.66949000
149MP0005332_abnormal_amino_acid0.66707411
150MP0001790_abnormal_immune_system0.64789474
151MP0005387_immune_system_phenotype0.64789474
152MP0002332_abnormal_exercise_endurance0.64110309
153MP0005253_abnormal_eye_physiology0.63316278
154MP0005257_abnormal_intraocular_pressure0.62580494
155MP0003937_abnormal_limbs/digits/tail_de0.62571203
156MP0002736_abnormal_nociception_after0.62264269
157MP0003634_abnormal_glial_cell0.62151524
158MP0008995_early_reproductive_senescence0.61207866

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.29285415
2Mitochondrial inheritance (HP:0001427)5.59483801
3Abnormality of cells of the erythroid lineage (HP:0012130)5.50859829
4Abnormal mitochondria in muscle tissue (HP:0008316)5.45013986
5Progressive macrocephaly (HP:0004481)5.26976671
6Increased hepatocellular lipid droplets (HP:0006565)5.17149886
7Abnormal number of erythroid precursors (HP:0012131)4.89044059
8Acute encephalopathy (HP:0006846)4.84492295
9Reticulocytopenia (HP:0001896)4.72263935
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.65562944
11Renal Fanconi syndrome (HP:0001994)4.51602723
12Increased CSF lactate (HP:0002490)4.51479276
13Lipid accumulation in hepatocytes (HP:0006561)4.45742400
14Parakeratosis (HP:0001036)4.42457500
15Hepatocellular necrosis (HP:0001404)4.33730140
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.12650036
17Macrocytic anemia (HP:0001972)4.02027761
183-Methylglutaconic aciduria (HP:0003535)3.88439100
19Exertional dyspnea (HP:0002875)3.75432984
20Hepatic necrosis (HP:0002605)3.74744079
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.73971116
22Pallor (HP:0000980)3.51639829
23Increased intramyocellular lipid droplets (HP:0012240)3.45432173
24Exercise intolerance (HP:0003546)3.37624384
25Optic disc pallor (HP:0000543)3.34400839
26Congenital ichthyosiform erythroderma (HP:0007431)3.34155121
27Septo-optic dysplasia (HP:0100842)3.34073867
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26559527
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26559527
30Respiratory failure (HP:0002878)3.18532986
31Leukodystrophy (HP:0002415)3.17127817
32Cerebral edema (HP:0002181)3.08921544
33Abnormality of renal resorption (HP:0011038)2.99452541
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94697019
35Abnormality of glycolysis (HP:0004366)2.94608352
36Increased serum pyruvate (HP:0003542)2.94608352
37Respiratory difficulties (HP:0002880)2.91013328
38Abnormal ciliary motility (HP:0012262)2.83089913
39Abnormal hemoglobin (HP:0011902)2.81216188
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.77414815
41Increased muscle lipid content (HP:0009058)2.76480327
42Abnormal respiratory motile cilium physiology (HP:0012261)2.73433198
43Abnormality of the axillary hair (HP:0100134)2.71104366
44Abnormality of secondary sexual hair (HP:0009888)2.71104366
45Pancreatic fibrosis (HP:0100732)2.62814832
46Pancreatic cysts (HP:0001737)2.61687896
47Congenital, generalized hypertrichosis (HP:0004540)2.54811649
48Abnormal respiratory epithelium morphology (HP:0012253)2.51358297
49Abnormal respiratory motile cilium morphology (HP:0005938)2.51358297
50Increased serum lactate (HP:0002151)2.50519312
51Abnormality of midbrain morphology (HP:0002418)2.50200627
52Molar tooth sign on MRI (HP:0002419)2.50200627
53Methylmalonic acidemia (HP:0002912)2.48573871
54Lactic acidosis (HP:0003128)2.48320283
55Hypothermia (HP:0002045)2.46532888
56True hermaphroditism (HP:0010459)2.46105375
57Sensory axonal neuropathy (HP:0003390)2.46074461
58Colon cancer (HP:0003003)2.42319708
59Aplastic anemia (HP:0001915)2.42015142
60Absent septum pellucidum (HP:0001331)2.41538173
61Lethargy (HP:0001254)2.32392243
62Oral leukoplakia (HP:0002745)2.29729486
63Recurrent abscess formation (HP:0002722)2.29480548
64Rhinitis (HP:0012384)2.23941182
65Concave nail (HP:0001598)2.16498091
66Methylmalonic aciduria (HP:0012120)2.14521417
67Abnormality of the labia minora (HP:0012880)2.11779453
68Nephronophthisis (HP:0000090)2.10734938
69Chronic obstructive pulmonary disease (HP:0006510)2.09388074
70Obstructive lung disease (HP:0006536)2.09388074
71Sclerocornea (HP:0000647)2.08231674
72Hyperphosphaturia (HP:0003109)2.07212581
73Patchy hypopigmentation of hair (HP:0011365)2.05603255
74Abnormality of urine glucose concentration (HP:0011016)2.04928789
75Glycosuria (HP:0003076)2.04928789
76Abnormal pupillary function (HP:0007686)2.04181304
77Abnormality of the septum pellucidum (HP:0007375)2.03981204
78Abnormality of methionine metabolism (HP:0010901)2.03549574
79Meckel diverticulum (HP:0002245)2.03376418
80Abnormality of placental membranes (HP:0011409)2.02479929
81Amniotic constriction ring (HP:0009775)2.02479929
82Triphalangeal thumb (HP:0001199)1.99397632
83Hyperglycinemia (HP:0002154)1.98567549
84Rib fusion (HP:0000902)1.96287598
85X-linked dominant inheritance (HP:0001423)1.96065999
86Abnormality of the ileum (HP:0001549)1.94582221
87CNS demyelination (HP:0007305)1.93742386
88Maternal diabetes (HP:0009800)1.90511773
89Abnormal urine phosphate concentration (HP:0012599)1.89417925
90Generalized aminoaciduria (HP:0002909)1.88808873
91Recurrent bacterial skin infections (HP:0005406)1.87242692
92Abnormality of serum amino acid levels (HP:0003112)1.87131215
93Aplasia/Hypoplasia of the uvula (HP:0010293)1.86852245
94Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86193700
95Absent thumb (HP:0009777)1.85799070
96Congenital primary aphakia (HP:0007707)1.85748558
97Hepatosplenomegaly (HP:0001433)1.83450468
98Optic nerve hypoplasia (HP:0000609)1.83433703
99Aplasia/hypoplasia of the uterus (HP:0008684)1.83039441
100Megaloblastic anemia (HP:0001889)1.82947622
101Renal tubular dysfunction (HP:0000124)1.82128619
102Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79554800
103White forelock (HP:0002211)1.78563528
104Vacuolated lymphocytes (HP:0001922)1.77410783
105Erythroderma (HP:0001019)1.76994132
106Stenosis of the external auditory canal (HP:0000402)1.76902550
107Esophageal atresia (HP:0002032)1.76691029
108Bilateral microphthalmos (HP:0007633)1.76022331
109Gait imbalance (HP:0002141)1.75542631
110Anophthalmia (HP:0000528)1.74376285
111Male pseudohermaphroditism (HP:0000037)1.73353503
112Reduced antithrombin III activity (HP:0001976)1.72971302
113Abnormality of the anterior horn cell (HP:0006802)1.72419587
114Degeneration of anterior horn cells (HP:0002398)1.72419587
115Abnormal protein glycosylation (HP:0012346)1.71407724
116Abnormal glycosylation (HP:0012345)1.71407724
117Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71407724
118Abnormal protein N-linked glycosylation (HP:0012347)1.71407724
119Vaginal atresia (HP:0000148)1.71178452
120Hypoplasia of the pons (HP:0012110)1.70619089
121Absent/shortened dynein arms (HP:0200106)1.69548535
122Dynein arm defect of respiratory motile cilia (HP:0012255)1.69548535
123Eczematoid dermatitis (HP:0000976)1.65415126
124Limb dystonia (HP:0002451)1.62911547
125Aplasia cutis congenita (HP:0001057)1.58968603
126Nasolacrimal duct obstruction (HP:0000579)1.58908165
127Elevated erythrocyte sedimentation rate (HP:0003565)1.57300067
128Blindness (HP:0000618)1.55523690
129Asplenia (HP:0001746)1.55359049
130Woolly hair (HP:0002224)1.54783584
131Partial duplication of thumb phalanx (HP:0009944)1.54452031
132Metaphyseal dysplasia (HP:0100255)1.52826185
133Hypoplastic left heart (HP:0004383)1.52617605
134Abnormality of macrophages (HP:0004311)1.50917922
135Glossoptosis (HP:0000162)1.50023792
136Poor head control (HP:0002421)1.49571061
137Paralysis (HP:0003470)1.49375153
138Cerebral hypomyelination (HP:0006808)1.48154519
139Neoplasm of head and neck (HP:0012288)1.47714682
140Esophageal neoplasm (HP:0100751)1.47714682
14111 pairs of ribs (HP:0000878)1.47611572
142Congenital malformation of the right heart (HP:0011723)1.47446120
143Double outlet right ventricle (HP:0001719)1.47446120
144Microvesicular hepatic steatosis (HP:0001414)1.47159130
145Type I transferrin isoform profile (HP:0003642)1.45963200
146Medial flaring of the eyebrow (HP:0010747)1.45739502
147Depressed nasal ridge (HP:0000457)1.45040067
148Septate vagina (HP:0001153)1.44593602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.07331090
2NME24.33174204
3MST43.69166030
4PBK3.64064891
5CDC72.97527729
6STK162.74323568
7TLK12.66843791
8STK392.61743408
9PIM22.26815179
10NME12.22021972
11LIMK12.19804380
12TNIK2.10845901
13BUB12.10790440
14VRK12.07658038
15SRPK12.06575582
16BMPR1B1.82431986
17IRAK41.81376778
18PLK31.81178381
19PNCK1.79805669
20WNK31.79261604
21GRK71.77686095
22NEK11.73950178
23TAF11.72875547
24NUAK11.72495937
25ARAF1.60760837
26TTK1.55937498
27BLK1.55002393
28BCR1.50847551
29OXSR11.46616217
30MYLK1.45982223
31CASK1.42863937
32BRSK21.36857042
33INSRR1.36332520
34EIF2AK31.36179691
35MAP4K21.32662045
36MAP3K121.29957107
37TESK11.29740129
38WEE11.29264755
39MAPK151.28798756
40PASK1.27368718
41FGR1.22573938
42ADRBK21.20170018
43MUSK1.19132825
44ABL21.17235557
45PLK11.15018342
46TESK21.13888468
47PKN11.11745896
48DYRK21.10440787
49MST1R1.08695767
50KDR1.08695671
51MAPKAPK51.04192028
52IRAK21.03488583
53CDK191.03409401
54WNK41.01957842
55BCKDK1.00598981
56IRAK11.00363972
57RPS6KA50.97985549
58BMPR20.96892527
59NEK20.94402066
60TRIM280.93895557
61LRRK20.92968767
62STK38L0.89872604
63MKNK10.89524037
64IRAK30.88886347
65CHEK20.88714558
66FES0.85582237
67EIF2AK20.85550750
68UHMK10.85212014
69EIF2AK10.84487498
70GRK50.83249102
71PDK20.81903302
72ILK0.81601256
73CSNK1G30.79963331
74AURKA0.78532118
75ADRBK10.77653745
76YES10.76007222
77ROCK20.75567341
78CLK10.75420388
79IKBKB0.74278398
80RIPK40.71877375
81ACVR1B0.71343341
82EPHB20.70055555
83TGFBR10.69191492
84FRK0.68675933
85OBSCN0.68407847
86GRK10.68137376
87TSSK60.67190117
88PLK20.67065445
89MAP2K20.66964242
90MAP3K40.66749526
91ATR0.64510020
92PRKCG0.64096692
93MET0.63979574
94CCNB10.63927725
95MAP3K140.63484051
96TEC0.62670494
97BRSK10.61805231
98DYRK30.61804272
99PLK40.61297443
100CDK30.60290806
101CDK80.59815432
102FGFR20.59481803
103LYN0.58523152
104PIK3CG0.58289050
105MAP2K70.58280199
106CAMK2D0.57654971
107CAMK2B0.57496132
108NEK60.56919139
109MAPK130.56364832
110DAPK30.54730467
111CSNK2A10.54626207
112IKBKE0.54453164
113MKNK20.54293508
114CSNK1G20.54166376
115PINK10.53922261
116STK40.52456817
117TRPM70.52448600
118BRAF0.51106909
119PRKCE0.51062216
120ZAK0.50805245
121RPS6KB20.50772706
122CSNK2A20.48597244
123FGFR10.48392943
124CSNK1G10.46621124
125EPHB10.46299683
126CSNK1E0.46060432
127STK30.45764533
128NLK0.44221696
129STK240.44108110
130EPHA40.44007900
131TIE10.42721959
132PAK10.42084283
133PAK40.41520711
134PRKCQ0.41139102
135LCK0.39218369
136TBK10.39113502
137ERBB40.38486106
138CSNK1A10.37932069
139AURKB0.35810561
140ATM0.35682252
141PRKCD0.35292130
142TXK0.34594917
143ROCK10.34246496
144PIK3CA0.32978878
145MOS0.32131243
146PRKACB0.31018540
147ERBB30.30498865

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.95445631
2Oxidative phosphorylation_Homo sapiens_hsa001905.48322841
3Parkinsons disease_Homo sapiens_hsa050124.57127891
4* Proteasome_Homo sapiens_hsa030503.68804572
5Alzheimers disease_Homo sapiens_hsa050103.55305785
6Huntingtons disease_Homo sapiens_hsa050163.40828764
7Protein export_Homo sapiens_hsa030603.27406091
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.10232239
9RNA polymerase_Homo sapiens_hsa030202.78260177
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.14688932
11Cardiac muscle contraction_Homo sapiens_hsa042601.90470436
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58393183
13Spliceosome_Homo sapiens_hsa030401.56841585
14Fatty acid elongation_Homo sapiens_hsa000621.49078041
15Pyrimidine metabolism_Homo sapiens_hsa002401.44711424
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38663748
17Steroid biosynthesis_Homo sapiens_hsa001001.30458404
18One carbon pool by folate_Homo sapiens_hsa006701.27912383
19Rheumatoid arthritis_Homo sapiens_hsa053231.26593645
20Graft-versus-host disease_Homo sapiens_hsa053321.21324022
21Ether lipid metabolism_Homo sapiens_hsa005651.19083034
22Collecting duct acid secretion_Homo sapiens_hsa049661.17001627
23Arachidonic acid metabolism_Homo sapiens_hsa005901.15641584
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13618643
25Nucleotide excision repair_Homo sapiens_hsa034201.11304508
26Basal transcription factors_Homo sapiens_hsa030221.10549175
27Sphingolipid metabolism_Homo sapiens_hsa006001.06886583
28Propanoate metabolism_Homo sapiens_hsa006401.03816356
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02589932
30DNA replication_Homo sapiens_hsa030301.00843295
31SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97652080
32Pyruvate metabolism_Homo sapiens_hsa006200.96255710
33Phagosome_Homo sapiens_hsa041450.93908312
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92454332
35Vibrio cholerae infection_Homo sapiens_hsa051100.92332836
36Asthma_Homo sapiens_hsa053100.90945226
37Glutathione metabolism_Homo sapiens_hsa004800.89962906
38Mismatch repair_Homo sapiens_hsa034300.88040201
39Allograft rejection_Homo sapiens_hsa053300.87731657
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85097167
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85095562
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.84129349
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81750141
44Malaria_Homo sapiens_hsa051440.81554070
45Autoimmune thyroid disease_Homo sapiens_hsa053200.79242389
46Sulfur metabolism_Homo sapiens_hsa009200.77822360
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77316253
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.77043972
49Linoleic acid metabolism_Homo sapiens_hsa005910.76796293
50Butanoate metabolism_Homo sapiens_hsa006500.76487358
51Purine metabolism_Homo sapiens_hsa002300.75682597
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74829228
53Cell cycle_Homo sapiens_hsa041100.73266799
54Chemical carcinogenesis_Homo sapiens_hsa052040.72873053
55Systemic lupus erythematosus_Homo sapiens_hsa053220.71631750
56* Homologous recombination_Homo sapiens_hsa034400.69674261
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68673354
58Non-homologous end-joining_Homo sapiens_hsa034500.68608356
59Nitrogen metabolism_Homo sapiens_hsa009100.67185255
60Selenocompound metabolism_Homo sapiens_hsa004500.64199103
61RNA degradation_Homo sapiens_hsa030180.63488840
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63002468
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62907939
64Vitamin digestion and absorption_Homo sapiens_hsa049770.60313988
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59952865
66Peroxisome_Homo sapiens_hsa041460.59852929
67Metabolic pathways_Homo sapiens_hsa011000.59659191
68Other glycan degradation_Homo sapiens_hsa005110.58967305
69Serotonergic synapse_Homo sapiens_hsa047260.57531669
70Tryptophan metabolism_Homo sapiens_hsa003800.57303554
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57055723
72Pertussis_Homo sapiens_hsa051330.56938646
73Tyrosine metabolism_Homo sapiens_hsa003500.55191464
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53765714
75Basal cell carcinoma_Homo sapiens_hsa052170.53569588
76Caffeine metabolism_Homo sapiens_hsa002320.52133368
77Retinol metabolism_Homo sapiens_hsa008300.51056246
78Hematopoietic cell lineage_Homo sapiens_hsa046400.48147036
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46200459
80Fanconi anemia pathway_Homo sapiens_hsa034600.44998329
81* Epstein-Barr virus infection_Homo sapiens_hsa051690.44732472
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44559950
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44391959
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.43790266
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43127745
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42952182
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.41541635
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41317555
89Phototransduction_Homo sapiens_hsa047440.39413396
90Legionellosis_Homo sapiens_hsa051340.38754659
91beta-Alanine metabolism_Homo sapiens_hsa004100.38722510
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.38357259
93Leishmaniasis_Homo sapiens_hsa051400.37227602
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.36766910
95Salmonella infection_Homo sapiens_hsa051320.36279624
96Base excision repair_Homo sapiens_hsa034100.35952563
97Nicotine addiction_Homo sapiens_hsa050330.35666703
98mRNA surveillance pathway_Homo sapiens_hsa030150.35164268
99Hedgehog signaling pathway_Homo sapiens_hsa043400.34734260
100Histidine metabolism_Homo sapiens_hsa003400.34724510
101Alcoholism_Homo sapiens_hsa050340.34489976
102RNA transport_Homo sapiens_hsa030130.34010960
103African trypanosomiasis_Homo sapiens_hsa051430.32715293
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32557961
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32531056
106Fatty acid degradation_Homo sapiens_hsa000710.32191899
107Oocyte meiosis_Homo sapiens_hsa041140.32061334
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31460311
109Folate biosynthesis_Homo sapiens_hsa007900.31290818
110Phenylalanine metabolism_Homo sapiens_hsa003600.29479112
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.26463440
112Antigen processing and presentation_Homo sapiens_hsa046120.26230194
113Type I diabetes mellitus_Homo sapiens_hsa049400.25582537
114Fat digestion and absorption_Homo sapiens_hsa049750.24799416
115Olfactory transduction_Homo sapiens_hsa047400.24626403
116Carbon metabolism_Homo sapiens_hsa012000.24182558
117Axon guidance_Homo sapiens_hsa043600.24144341
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23144835
119N-Glycan biosynthesis_Homo sapiens_hsa005100.22826661
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21569897
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21530049
122Arginine and proline metabolism_Homo sapiens_hsa003300.21277725
123Taste transduction_Homo sapiens_hsa047420.19850364
124Tuberculosis_Homo sapiens_hsa051520.19779898
125Regulation of autophagy_Homo sapiens_hsa041400.19030552
126Viral myocarditis_Homo sapiens_hsa054160.18836455
127Lysosome_Homo sapiens_hsa041420.17637396
128Primary immunodeficiency_Homo sapiens_hsa053400.17633931
129Shigellosis_Homo sapiens_hsa051310.17416290
130TGF-beta signaling pathway_Homo sapiens_hsa043500.16651075
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16289785
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14638026
133Measles_Homo sapiens_hsa051620.14476287
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12828423
135Sulfur relay system_Homo sapiens_hsa041220.12773941
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.12770774
137Apoptosis_Homo sapiens_hsa042100.12353493
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.12178868
139p53 signaling pathway_Homo sapiens_hsa041150.11771117
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11746351
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.10437417
142Herpes simplex infection_Homo sapiens_hsa051680.10369523
143Mineral absorption_Homo sapiens_hsa049780.09214587

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