SHFM1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)8.21603278
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.21603278
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.66995627
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.75584734
5establishment of protein localization to mitochondrial membrane (GO:0090151)6.26372374
6chaperone-mediated protein transport (GO:0072321)5.91376916
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.72266789
8mitochondrial respiratory chain complex I assembly (GO:0032981)5.72266789
9NADH dehydrogenase complex assembly (GO:0010257)5.72266789
10protein complex biogenesis (GO:0070271)5.68040820
11respiratory electron transport chain (GO:0022904)5.58110073
12electron transport chain (GO:0022900)5.45959117
13mitochondrial respiratory chain complex assembly (GO:0033108)5.06592413
14viral transcription (GO:0019083)4.93458471
15preassembly of GPI anchor in ER membrane (GO:0016254)4.89895283
16positive regulation of vesicle fusion (GO:0031340)4.86382926
17response to dietary excess (GO:0002021)4.84934979
18protein neddylation (GO:0045116)4.84501376
19response to redox state (GO:0051775)4.83160854
20translational termination (GO:0006415)4.78871811
21ribosomal small subunit assembly (GO:0000028)4.74920385
22ATP biosynthetic process (GO:0006754)4.73659552
23regulation of oxidative phosphorylation (GO:0002082)4.63455269
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.39491190
25nonmotile primary cilium assembly (GO:0035058)4.32890949
26protein targeting to ER (GO:0045047)4.32795174
27cotranslational protein targeting to membrane (GO:0006613)4.31488350
28oxygen transport (GO:0015671)4.24011047
29purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.23584872
30establishment of protein localization to endoplasmic reticulum (GO:0072599)4.20269501
31purine nucleoside triphosphate biosynthetic process (GO:0009145)4.19883026
32platelet dense granule organization (GO:0060155)4.13174712
33left/right axis specification (GO:0070986)4.11323288
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.10975988
35tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.10975988
36protein localization to endoplasmic reticulum (GO:0070972)4.07466509
37maturation of SSU-rRNA (GO:0030490)4.04710532
38hydrogen ion transmembrane transport (GO:1902600)3.81751391
39ribosomal small subunit biogenesis (GO:0042274)3.74986692
40translational elongation (GO:0006414)3.74039404
41intracellular protein transmembrane import (GO:0044743)3.68006900
42cellular protein complex disassembly (GO:0043624)3.67623964
43GPI anchor biosynthetic process (GO:0006506)3.65496404
44behavioral response to nicotine (GO:0035095)3.60574922
45GPI anchor metabolic process (GO:0006505)3.56030850
46positive regulation of prostaglandin secretion (GO:0032308)3.54541362
47ribonucleoside triphosphate biosynthetic process (GO:0009201)3.54531869
48viral life cycle (GO:0019058)3.53130892
49negative regulation of heart rate (GO:0010459)3.51564287
50gas transport (GO:0015669)3.45903438
51oxidative phosphorylation (GO:0006119)3.44620046
52aldehyde catabolic process (GO:0046185)3.43601504
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.41251000
54protein peptidyl-prolyl isomerization (GO:0000413)3.40354622
55forebrain neuron differentiation (GO:0021879)3.36625210
56protein-cofactor linkage (GO:0018065)3.36612264
57proton transport (GO:0015992)3.34307315
58substrate-independent telencephalic tangential migration (GO:0021826)3.27980427
59substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.27980427
60hydrogen transport (GO:0006818)3.24670699
61nucleoside triphosphate biosynthetic process (GO:0009142)3.18495561
62regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.18225296
63regulation of mitochondrial translation (GO:0070129)3.15893588
64positive regulation of icosanoid secretion (GO:0032305)3.14907403
65positive regulation of protein homodimerization activity (GO:0090073)3.13898818
66establishment of protein localization to mitochondrion (GO:0072655)3.12237940
67regulation of cellular respiration (GO:0043457)3.11803434
68protein complex disassembly (GO:0043241)3.10650031
69translation (GO:0006412)3.08818090
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07178322
71translational initiation (GO:0006413)3.05227232
72respiratory chain complex IV assembly (GO:0008535)3.04962039
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04453841
74protein targeting to mitochondrion (GO:0006626)3.03991339
75positive regulation of mast cell degranulation (GO:0043306)3.03684779
76positive regulation of mast cell activation involved in immune response (GO:0033008)3.03684779
77neuronal action potential propagation (GO:0019227)3.00962133
78ribosomal large subunit biogenesis (GO:0042273)2.98935698
79macromolecular complex disassembly (GO:0032984)2.98747423
80protein targeting to membrane (GO:0006612)2.95895907
81C-terminal protein lipidation (GO:0006501)2.94337180
82cellular component biogenesis (GO:0044085)2.90732336
83proteasome assembly (GO:0043248)2.90377841
84regulation of hypersensitivity (GO:0002883)2.88793047
85spinal cord association neuron differentiation (GO:0021527)2.88714956
86positive regulation of fatty acid transport (GO:2000193)2.83803954
87protein localization to mitochondrion (GO:0070585)2.82892712
88protein prenylation (GO:0018342)2.81484846
89prenylation (GO:0097354)2.81484846
90microtubule severing (GO:0051013)2.79193033
91forebrain morphogenesis (GO:0048853)2.78382688
92mitochondrial transport (GO:0006839)2.76406004
93regulation of prostaglandin secretion (GO:0032306)2.73588054
94short-chain fatty acid metabolic process (GO:0046459)2.72748704
95somite development (GO:0061053)2.72467559
96intracellular protein transmembrane transport (GO:0065002)2.72058264
97purine nucleoside monophosphate biosynthetic process (GO:0009127)2.71002722
98purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.71002722
99dopamine transport (GO:0015872)2.70748005
100lactate metabolic process (GO:0006089)2.66024232

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.68508620
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42295684
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.00298477
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.66140183
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59073148
6CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52432625
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.41404647
8ZNF274_21170338_ChIP-Seq_K562_Hela2.39424422
9TAF15_26573619_Chip-Seq_HEK293_Human2.33750198
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19855182
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12458025
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.08158401
13VDR_22108803_ChIP-Seq_LS180_Human2.05564311
14EWS_26573619_Chip-Seq_HEK293_Human2.03870300
15ETS1_20019798_ChIP-Seq_JURKAT_Human1.97151167
16IGF1R_20145208_ChIP-Seq_DFB_Human1.93727601
17VDR_23849224_ChIP-Seq_CD4+_Human1.92796894
18ELK1_19687146_ChIP-ChIP_HELA_Human1.91368296
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.88589280
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83211963
21IRF1_19129219_ChIP-ChIP_H3396_Human1.83016936
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79890017
23EZH2_22144423_ChIP-Seq_EOC_Human1.79857436
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77046962
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69623125
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69108936
27P300_19829295_ChIP-Seq_ESCs_Human1.64621521
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.63966514
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.62709097
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61814767
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61085408
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60501699
33TP53_22573176_ChIP-Seq_HFKS_Human1.55741701
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54449627
35MYC_18940864_ChIP-ChIP_HL60_Human1.53139306
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.47782212
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47661930
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.46862473
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44139849
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42615393
41ER_23166858_ChIP-Seq_MCF-7_Human1.41788864
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41360471
43RNF2_27304074_Chip-Seq_NSC_Mouse1.40595730
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39547905
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38751374
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.38661234
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37676955
48TTF2_22483619_ChIP-Seq_HELA_Human1.35587974
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.35514152
50GABP_19822575_ChIP-Seq_HepG2_Human1.35034451
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34610428
52FUS_26573619_Chip-Seq_HEK293_Human1.32791134
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29931270
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29911031
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29824345
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.29048372
57SOX2_19829295_ChIP-Seq_ESCs_Human1.28056206
58NANOG_19829295_ChIP-Seq_ESCs_Human1.28056206
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25122390
60FOXP3_21729870_ChIP-Seq_TREG_Human1.24869317
61NCOR_22424771_ChIP-Seq_293T_Human1.18765988
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18380024
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15751906
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15252681
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14368178
66TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13835335
67ERG_20517297_ChIP-Seq_VCAP_Human1.13632587
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13592789
69AR_25329375_ChIP-Seq_VCAP_Human1.12796647
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.11017239
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11017239
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.10585243
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09877406
74AR_20517297_ChIP-Seq_VCAP_Human1.08652222
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.07905437
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07893009
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07237392
78XRN2_22483619_ChIP-Seq_HELA_Human1.06836680
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04485475
80SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04449129
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04438670
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03811754
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03560331
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.01647313
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00724765
86ERA_21632823_ChIP-Seq_H3396_Human1.00514465
87TCF4_22108803_ChIP-Seq_LS180_Human1.00153135
88TAL1_26923725_Chip-Seq_HPCs_Mouse0.99860873
89NANOG_18555785_Chip-Seq_ESCs_Mouse0.99185338
90REST_21632747_ChIP-Seq_MESCs_Mouse0.98309635
91P53_22387025_ChIP-Seq_ESCs_Mouse0.97137337
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96077130
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95842448
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95441702
95P53_21459846_ChIP-Seq_SAOS-2_Human0.94040421
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93853825
97RUNX2_22187159_ChIP-Seq_PCA_Human0.93309613
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93161302
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.92591016
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92435475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.11630096
2MP0008789_abnormal_olfactory_epithelium3.79376646
3MP0006292_abnormal_olfactory_placode3.76978657
4MP0009379_abnormal_foot_pigmentation3.40574909
5MP0002822_catalepsy3.19187020
6MP0005499_abnormal_olfactory_system2.85786895
7MP0005394_taste/olfaction_phenotype2.85786895
8MP0001188_hyperpigmentation2.64337573
9MP0003787_abnormal_imprinting2.50256517
10MP0001529_abnormal_vocalization2.45859319
11MP0002163_abnormal_gland_morphology2.44192884
12MP0004885_abnormal_endolymph2.37321744
13MP0006276_abnormal_autonomic_nervous2.32224238
14MP0004142_abnormal_muscle_tone2.23144884
15MP0004147_increased_porphyrin_level2.22865760
16MP0008877_abnormal_DNA_methylation2.07557670
17MP0006072_abnormal_retinal_apoptosis2.04764279
18MP0005171_absent_coat_pigmentation2.03005489
19MP0003880_abnormal_central_pattern1.99090585
20MP0005423_abnormal_somatic_nervous1.94420089
21MP0003122_maternal_imprinting1.84524448
22MP0003646_muscle_fatigue1.79174887
23MP0003806_abnormal_nucleotide_metabolis1.77079630
24MP0009046_muscle_twitch1.70430374
25MP0008995_early_reproductive_senescence1.69352702
26MP0000631_abnormal_neuroendocrine_gland1.64170823
27MP0000049_abnormal_middle_ear1.63771923
28MP0003121_genomic_imprinting1.63338977
29MP0005646_abnormal_pituitary_gland1.54735955
30MP0005085_abnormal_gallbladder_physiolo1.53315589
31MP0001919_abnormal_reproductive_system1.53302014
32MP0005389_reproductive_system_phenotype1.50108599
33MP0003186_abnormal_redox_activity1.50053257
34MP0001905_abnormal_dopamine_level1.49626215
35MP0008872_abnormal_physiological_respon1.49619884
36MP0002837_dystrophic_cardiac_calcinosis1.47336089
37MP0001293_anophthalmia1.43443198
38MP0003195_calcinosis1.40560306
39MP0003136_yellow_coat_color1.33991504
40MP0005645_abnormal_hypothalamus_physiol1.28842058
41MP0005379_endocrine/exocrine_gland_phen1.28414646
42MP0002638_abnormal_pupillary_reflex1.26761524
43MP0001485_abnormal_pinna_reflex1.26127483
44MP0002653_abnormal_ependyma_morphology1.23809993
45MP0003123_paternal_imprinting1.22679408
46MP0006036_abnormal_mitochondrial_physio1.22000319
47MP0005084_abnormal_gallbladder_morpholo1.18548818
48MP0002160_abnormal_reproductive_system1.14116271
49MP0002233_abnormal_nose_morphology1.13712285
50MP0009745_abnormal_behavioral_response1.12800324
51MP0003137_abnormal_impulse_conducting1.10986875
52MP0005551_abnormal_eye_electrophysiolog1.10416803
53MP0003786_premature_aging1.09368785
54MP0004085_abnormal_heartbeat1.05768465
55MP0005253_abnormal_eye_physiology1.04200518
56MP0002102_abnormal_ear_morphology1.04138164
57MP0002572_abnormal_emotion/affect_behav1.03461903
58MP0002557_abnormal_social/conspecific_i1.03073239
59MP0004133_heterotaxia1.02620472
60MP0005503_abnormal_tendon_morphology0.97914445
61MP0001963_abnormal_hearing_physiology0.97838173
62MP0002095_abnormal_skin_pigmentation0.95934651
63MP0001486_abnormal_startle_reflex0.95873932
64MP0000026_abnormal_inner_ear0.94404209
65MP0009697_abnormal_copulation0.94128127
66MP0005187_abnormal_penis_morphology0.92828742
67MP0002272_abnormal_nervous_system0.90811336
68MP0001440_abnormal_grooming_behavior0.89629559
69MP0003011_delayed_dark_adaptation0.89035509
70MP0001968_abnormal_touch/_nociception0.86089264
71MP0003941_abnormal_skin_development0.85805708
72MP0002751_abnormal_autonomic_nervous0.85487400
73MP0002234_abnormal_pharynx_morphology0.85011231
74MP0000749_muscle_degeneration0.83435415
75MP0000639_abnormal_adrenal_gland0.83417909
76MP0000681_abnormal_thyroid_gland0.83135708
77MP0005220_abnormal_exocrine_pancreas0.82000963
78MP0003724_increased_susceptibility_to0.81958456
79MP0000647_abnormal_sebaceous_gland0.80243039
80MP0000230_abnormal_systemic_arterial0.80073378
81MP0001970_abnormal_pain_threshold0.79724349
82MP0002938_white_spotting0.78252081
83MP0005195_abnormal_posterior_eye0.78121136
84MP0001986_abnormal_taste_sensitivity0.77780347
85MP0003119_abnormal_digestive_system0.77371959
86MP0004381_abnormal_hair_follicle0.77141149
87MP0004742_abnormal_vestibular_system0.74876146
88MP0002735_abnormal_chemical_nociception0.72996609
89MP0002752_abnormal_somatic_nervous0.70879233
90MP0002064_seizures0.70524698
91MP0002184_abnormal_innervation0.69831609
92MP0005636_abnormal_mineral_homeostasis0.69003946
93MP0002734_abnormal_mechanical_nocicepti0.68737152
94MP0001727_abnormal_embryo_implantation0.67867286
95MP0003567_abnormal_fetal_cardiomyocyte0.67465348
96MP0004145_abnormal_muscle_electrophysio0.66510374
97MP0001764_abnormal_homeostasis0.64871400
98MP0005075_abnormal_melanosome_morpholog0.64163374
99MP0003937_abnormal_limbs/digits/tail_de0.64131250
100MP0003938_abnormal_ear_development0.63601253

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.35870808
23-Methylglutaconic aciduria (HP:0003535)5.24928637
3Acute encephalopathy (HP:0006846)5.24308351
4Abnormal mitochondria in muscle tissue (HP:0008316)4.84709384
5Mitochondrial inheritance (HP:0001427)4.75352281
6Lipid accumulation in hepatocytes (HP:0006561)4.66621060
7Progressive macrocephaly (HP:0004481)4.57106830
8Abnormal hemoglobin (HP:0011902)4.31910157
9Increased CSF lactate (HP:0002490)4.27096087
10Absent rod-and cone-mediated responses on ERG (HP:0007688)4.19787799
11Increased hepatocellular lipid droplets (HP:0006565)4.12982958
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.01838964
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.01838964
14Increased intramyocellular lipid droplets (HP:0012240)3.62393698
15Renal Fanconi syndrome (HP:0001994)3.59175780
16Increased muscle lipid content (HP:0009058)3.57283914
17Cerebral edema (HP:0002181)3.54531375
18Hypothermia (HP:0002045)3.50664752
19Methylmalonic acidemia (HP:0002912)3.49686297
20Hepatocellular necrosis (HP:0001404)3.46914286
21Decreased central vision (HP:0007663)3.31604038
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.24421150
23Degeneration of the lateral corticospinal tracts (HP:0002314)3.24421150
24Delayed CNS myelination (HP:0002188)3.13462351
25Abnormal rod and cone electroretinograms (HP:0008323)3.05836256
26Pallor (HP:0000980)3.00209401
27Hepatic necrosis (HP:0002605)2.96987652
28Abnormality of the heme biosynthetic pathway (HP:0010472)2.66270112
29Exertional dyspnea (HP:0002875)2.64778811
30Abnormality of midbrain morphology (HP:0002418)2.63546533
31Molar tooth sign on MRI (HP:0002419)2.63546533
32Stenosis of the external auditory canal (HP:0000402)2.59877791
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54330272
34Abnormality of renal resorption (HP:0011038)2.54058114
35Congenital primary aphakia (HP:0007707)2.51630632
36Nephrogenic diabetes insipidus (HP:0009806)2.50762693
37Gait imbalance (HP:0002141)2.45061336
38Nephronophthisis (HP:0000090)2.44965665
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42124760
40Medial flaring of the eyebrow (HP:0010747)2.41934437
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.40171187
42Lactic acidosis (HP:0003128)2.39913805
43Abnormality of cells of the erythroid lineage (HP:0012130)2.39115507
44Increased serum lactate (HP:0002151)2.38010410
45True hermaphroditism (HP:0010459)2.37391867
46Pancreatic fibrosis (HP:0100732)2.37303154
47Respiratory difficulties (HP:0002880)2.36795524
48Exercise intolerance (HP:0003546)2.34624015
49Bony spicule pigmentary retinopathy (HP:0007737)2.33968347
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33546103
51Optic disc pallor (HP:0000543)2.31163591
52Pancreatic cysts (HP:0001737)2.30950371
53Pendular nystagmus (HP:0012043)2.29669232
54Methylmalonic aciduria (HP:0012120)2.29215121
55Respiratory failure (HP:0002878)2.27992194
56Congenital, generalized hypertrichosis (HP:0004540)2.25368853
57Abnormality of the corticospinal tract (HP:0002492)2.24211821
58Leukodystrophy (HP:0002415)2.16190823
59Agitation (HP:0000713)2.14686411
60Thyroid-stimulating hormone excess (HP:0002925)2.13924770
61Hyperglycinemia (HP:0002154)2.05283342
62Abnormal respiratory motile cilium physiology (HP:0012261)1.99732235
63Macrocytic anemia (HP:0001972)1.96070686
64Abnormal respiratory epithelium morphology (HP:0012253)1.95549735
65Abnormal respiratory motile cilium morphology (HP:0005938)1.95549735
66Intestinal atresia (HP:0011100)1.95528819
67Abnormality of the renal medulla (HP:0100957)1.94157634
68Decreased subcutaneous fat (HP:0001002)1.93388017
69Adrenal hypoplasia (HP:0000835)1.92927772
70Abnormality of lateral ventricle (HP:0030047)1.92403062
71Abnormality of urine glucose concentration (HP:0011016)1.92015939
72Glycosuria (HP:0003076)1.92015939
73CNS demyelination (HP:0007305)1.91232067
74Azoospermia (HP:0000027)1.87364583
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86097772
76Epileptic encephalopathy (HP:0200134)1.85407221
77Abnormality of the anterior horn cell (HP:0006802)1.85397502
78Degeneration of anterior horn cells (HP:0002398)1.85397502
79Constricted visual fields (HP:0001133)1.85372431
80Hyperphosphaturia (HP:0003109)1.83752671
81Genital tract atresia (HP:0001827)1.83400110
82Vaginal atresia (HP:0000148)1.82855175
83Chronic hepatic failure (HP:0100626)1.82782573
84X-linked dominant inheritance (HP:0001423)1.82738412
85Hypoplasia of the uterus (HP:0000013)1.81953080
86Abnormality of vitamin B metabolism (HP:0004340)1.81256242
87Concave nail (HP:0001598)1.80133035
88Abnormality of the vitamin B12 metabolism (HP:0004341)1.79375081
89Lethargy (HP:0001254)1.79260664
90Supernumerary spleens (HP:0009799)1.79201154
91Abnormal ciliary motility (HP:0012262)1.79016169
92Abnormal number of erythroid precursors (HP:0012131)1.77730339
93Abolished electroretinogram (ERG) (HP:0000550)1.74445476
94Erythroderma (HP:0001019)1.72361715
95Growth hormone deficiency (HP:0000824)1.72237099
96Aplasia/hypoplasia of the uterus (HP:0008684)1.72097499
97Sclerocornea (HP:0000647)1.69980092
98Large eyes (HP:0001090)1.69939779
99Split foot (HP:0001839)1.69561959
100Reticulocytopenia (HP:0001896)1.68315739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.17069549
2MAP3K123.37275154
3PINK13.07891964
4MAP4K22.97972810
5NME22.81089492
6BRAF2.31189725
7GRK12.29922150
8TLK12.20104708
9BMPR22.12012577
10MYLK1.81426942
11SRPK11.80355291
12CSNK1G31.79838194
13FRK1.74103592
14BUB11.73504645
15CSNK1G21.71871851
16CDK191.71607412
17PIK3CA1.61023306
18SCYL21.55043780
19CSNK1G11.52902793
20NEK11.52084921
21BCKDK1.47258618
22PLK41.40223419
23CSNK1A1L1.38031176
24DYRK21.25048882
25BRSK11.18996066
26ZAK1.18625230
27ADRBK21.14455580
28TAOK31.10137253
29ERBB31.09828127
30TNK21.08237227
31PLK21.03492562
32PHKG21.02406728
33PHKG11.02406728
34TRIM281.01015330
35AURKB0.98988213
36VRK20.98226652
37INSRR0.97675674
38RPS6KA40.94946791
39DAPK30.94159852
40LMTK20.93336216
41WNK30.92254830
42ILK0.90527549
43WNK40.90490927
44WEE10.87996732
45LIMK10.87600927
46DYRK30.86824084
47BCR0.85986650
48STK110.84377526
49BMPR1B0.83671997
50CDC70.80057662
51NEK20.79498612
52ERBB40.77146622
53CAMKK20.76302677
54AURKA0.76038334
55CCNB10.73763783
56STK160.72423764
57NME10.72333556
58OBSCN0.70902317
59BRSK20.68675342
60PRKACA0.67857987
61CSNK2A10.66119939
62MINK10.65452592
63SGK4940.63545768
64SGK2230.63545768
65CSNK2A20.61342891
66VRK10.59041542
67PRKCG0.57025162
68PAK40.56147301
69DAPK10.55603930
70CDK30.54610875
71CSNK1A10.52670816
72ERBB20.52472912
73BTK0.51620578
74PLK10.51460186
75PDK20.50819107
76ADRBK10.50700223
77PRKG10.49056270
78CAMK2D0.49001285
79CASK0.48438059
80DAPK20.48085667
81SGK20.47509736
82PAK10.47140752
83EPHB20.46940896
84NUAK10.46760795
85PIM20.46256968
86CAMK2A0.45592467
87CSNK1E0.45095599
88ROCK10.44689542
89PRKCE0.43792540
90RPS6KA50.43235024
91PLK30.42950864
92ATR0.42157285
93CAMK10.41787776
94MAPKAPK50.41720624
95ARAF0.41330957
96EGFR0.39502803
97PAK30.38996417
98WNK10.38479594
99MAPK150.37589458
100PRKACB0.36857659

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.67026950
2Parkinsons disease_Homo sapiens_hsa050124.87395640
3Ribosome_Homo sapiens_hsa030104.38179105
4Alzheimers disease_Homo sapiens_hsa050103.43824934
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.43099209
6Huntingtons disease_Homo sapiens_hsa050163.29821718
7Protein export_Homo sapiens_hsa030603.27033104
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.14477044
9Proteasome_Homo sapiens_hsa030503.00728399
10Cardiac muscle contraction_Homo sapiens_hsa042602.78298886
11Asthma_Homo sapiens_hsa053102.05843395
12RNA polymerase_Homo sapiens_hsa030201.92971535
13Homologous recombination_Homo sapiens_hsa034401.91265424
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77240997
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51313562
16Butanoate metabolism_Homo sapiens_hsa006501.40210530
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.40187961
18Basal transcription factors_Homo sapiens_hsa030221.25518761
19Propanoate metabolism_Homo sapiens_hsa006401.22013462
20Collecting duct acid secretion_Homo sapiens_hsa049661.19055388
21Olfactory transduction_Homo sapiens_hsa047401.15590981
22Peroxisome_Homo sapiens_hsa041461.13504794
23Nucleotide excision repair_Homo sapiens_hsa034201.11441191
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03877647
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.01595994
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99926300
27Phototransduction_Homo sapiens_hsa047440.99713397
28RNA degradation_Homo sapiens_hsa030180.99100138
29Caffeine metabolism_Homo sapiens_hsa002320.96525563
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95732966
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92169161
32Linoleic acid metabolism_Homo sapiens_hsa005910.89676681
33beta-Alanine metabolism_Homo sapiens_hsa004100.87501777
34Chemical carcinogenesis_Homo sapiens_hsa052040.83859374
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82285488
36Base excision repair_Homo sapiens_hsa034100.81464550
37Hedgehog signaling pathway_Homo sapiens_hsa043400.79606229
38Metabolic pathways_Homo sapiens_hsa011000.78553669
39Pyrimidine metabolism_Homo sapiens_hsa002400.77811518
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.77535788
41Mismatch repair_Homo sapiens_hsa034300.77136436
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76617535
43DNA replication_Homo sapiens_hsa030300.75177359
44Spliceosome_Homo sapiens_hsa030400.75092516
45Fanconi anemia pathway_Homo sapiens_hsa034600.74256447
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73434694
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71799976
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70343517
49Fat digestion and absorption_Homo sapiens_hsa049750.69508691
50Glutathione metabolism_Homo sapiens_hsa004800.66205265
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64348063
52Phenylalanine metabolism_Homo sapiens_hsa003600.63538316
53Pyruvate metabolism_Homo sapiens_hsa006200.63434588
54Retinol metabolism_Homo sapiens_hsa008300.63327574
55Tyrosine metabolism_Homo sapiens_hsa003500.61485627
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.60970961
57Nicotine addiction_Homo sapiens_hsa050330.58949294
58One carbon pool by folate_Homo sapiens_hsa006700.57311523
59Purine metabolism_Homo sapiens_hsa002300.57026510
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.53887241
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53842203
62Type I diabetes mellitus_Homo sapiens_hsa049400.52106457
63Rheumatoid arthritis_Homo sapiens_hsa053230.49648607
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49402768
65Morphine addiction_Homo sapiens_hsa050320.48760469
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48253248
67Tryptophan metabolism_Homo sapiens_hsa003800.48072354
68Basal cell carcinoma_Homo sapiens_hsa052170.47071120
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46788923
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44671784
71Fatty acid elongation_Homo sapiens_hsa000620.43861344
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43534731
73Insulin secretion_Homo sapiens_hsa049110.42440453
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.41749718
75GABAergic synapse_Homo sapiens_hsa047270.39949928
76p53 signaling pathway_Homo sapiens_hsa041150.38631616
77Vibrio cholerae infection_Homo sapiens_hsa051100.38355638
78RNA transport_Homo sapiens_hsa030130.37227677
79Serotonergic synapse_Homo sapiens_hsa047260.37167066
80Ether lipid metabolism_Homo sapiens_hsa005650.34804837
81Regulation of autophagy_Homo sapiens_hsa041400.34315616
82Taste transduction_Homo sapiens_hsa047420.34069419
83Sulfur relay system_Homo sapiens_hsa041220.33508127
84Sulfur metabolism_Homo sapiens_hsa009200.32032376
85Malaria_Homo sapiens_hsa051440.31975223
86Oocyte meiosis_Homo sapiens_hsa041140.30680323
87Mineral absorption_Homo sapiens_hsa049780.27903901
88Systemic lupus erythematosus_Homo sapiens_hsa053220.26684345
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26325795
90Steroid biosynthesis_Homo sapiens_hsa001000.25565499
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24928541
92Allograft rejection_Homo sapiens_hsa053300.24677836
93Starch and sucrose metabolism_Homo sapiens_hsa005000.24193774
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23465615
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22993526
96Graft-versus-host disease_Homo sapiens_hsa053320.22931783
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22093241
98Nitrogen metabolism_Homo sapiens_hsa009100.21446659
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21380804
100Fatty acid degradation_Homo sapiens_hsa000710.20964865

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