

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ATP synthesis coupled proton transport (GO:0015986) | 8.21603278 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 8.21603278 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.66995627 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 6.75584734 |
| 5 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 6.26372374 |
| 6 | chaperone-mediated protein transport (GO:0072321) | 5.91376916 |
| 7 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 5.72266789 |
| 8 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 5.72266789 |
| 9 | NADH dehydrogenase complex assembly (GO:0010257) | 5.72266789 |
| 10 | protein complex biogenesis (GO:0070271) | 5.68040820 |
| 11 | respiratory electron transport chain (GO:0022904) | 5.58110073 |
| 12 | electron transport chain (GO:0022900) | 5.45959117 |
| 13 | mitochondrial respiratory chain complex assembly (GO:0033108) | 5.06592413 |
| 14 | viral transcription (GO:0019083) | 4.93458471 |
| 15 | preassembly of GPI anchor in ER membrane (GO:0016254) | 4.89895283 |
| 16 | positive regulation of vesicle fusion (GO:0031340) | 4.86382926 |
| 17 | response to dietary excess (GO:0002021) | 4.84934979 |
| 18 | protein neddylation (GO:0045116) | 4.84501376 |
| 19 | response to redox state (GO:0051775) | 4.83160854 |
| 20 | translational termination (GO:0006415) | 4.78871811 |
| 21 | ribosomal small subunit assembly (GO:0000028) | 4.74920385 |
| 22 | ATP biosynthetic process (GO:0006754) | 4.73659552 |
| 23 | regulation of oxidative phosphorylation (GO:0002082) | 4.63455269 |
| 24 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.39491190 |
| 25 | nonmotile primary cilium assembly (GO:0035058) | 4.32890949 |
| 26 | protein targeting to ER (GO:0045047) | 4.32795174 |
| 27 | cotranslational protein targeting to membrane (GO:0006613) | 4.31488350 |
| 28 | oxygen transport (GO:0015671) | 4.24011047 |
| 29 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 4.23584872 |
| 30 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.20269501 |
| 31 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 4.19883026 |
| 32 | platelet dense granule organization (GO:0060155) | 4.13174712 |
| 33 | left/right axis specification (GO:0070986) | 4.11323288 |
| 34 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.10975988 |
| 35 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.10975988 |
| 36 | protein localization to endoplasmic reticulum (GO:0070972) | 4.07466509 |
| 37 | maturation of SSU-rRNA (GO:0030490) | 4.04710532 |
| 38 | hydrogen ion transmembrane transport (GO:1902600) | 3.81751391 |
| 39 | ribosomal small subunit biogenesis (GO:0042274) | 3.74986692 |
| 40 | translational elongation (GO:0006414) | 3.74039404 |
| 41 | intracellular protein transmembrane import (GO:0044743) | 3.68006900 |
| 42 | cellular protein complex disassembly (GO:0043624) | 3.67623964 |
| 43 | GPI anchor biosynthetic process (GO:0006506) | 3.65496404 |
| 44 | behavioral response to nicotine (GO:0035095) | 3.60574922 |
| 45 | GPI anchor metabolic process (GO:0006505) | 3.56030850 |
| 46 | positive regulation of prostaglandin secretion (GO:0032308) | 3.54541362 |
| 47 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.54531869 |
| 48 | viral life cycle (GO:0019058) | 3.53130892 |
| 49 | negative regulation of heart rate (GO:0010459) | 3.51564287 |
| 50 | gas transport (GO:0015669) | 3.45903438 |
| 51 | oxidative phosphorylation (GO:0006119) | 3.44620046 |
| 52 | aldehyde catabolic process (GO:0046185) | 3.43601504 |
| 53 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.41251000 |
| 54 | protein peptidyl-prolyl isomerization (GO:0000413) | 3.40354622 |
| 55 | forebrain neuron differentiation (GO:0021879) | 3.36625210 |
| 56 | protein-cofactor linkage (GO:0018065) | 3.36612264 |
| 57 | proton transport (GO:0015992) | 3.34307315 |
| 58 | substrate-independent telencephalic tangential migration (GO:0021826) | 3.27980427 |
| 59 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 3.27980427 |
| 60 | hydrogen transport (GO:0006818) | 3.24670699 |
| 61 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.18495561 |
| 62 | regulation of acute inflammatory response to antigenic stimulus (GO:0002864) | 3.18225296 |
| 63 | regulation of mitochondrial translation (GO:0070129) | 3.15893588 |
| 64 | positive regulation of icosanoid secretion (GO:0032305) | 3.14907403 |
| 65 | positive regulation of protein homodimerization activity (GO:0090073) | 3.13898818 |
| 66 | establishment of protein localization to mitochondrion (GO:0072655) | 3.12237940 |
| 67 | regulation of cellular respiration (GO:0043457) | 3.11803434 |
| 68 | protein complex disassembly (GO:0043241) | 3.10650031 |
| 69 | translation (GO:0006412) | 3.08818090 |
| 70 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.07178322 |
| 71 | translational initiation (GO:0006413) | 3.05227232 |
| 72 | respiratory chain complex IV assembly (GO:0008535) | 3.04962039 |
| 73 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.04453841 |
| 74 | protein targeting to mitochondrion (GO:0006626) | 3.03991339 |
| 75 | positive regulation of mast cell degranulation (GO:0043306) | 3.03684779 |
| 76 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.03684779 |
| 77 | neuronal action potential propagation (GO:0019227) | 3.00962133 |
| 78 | ribosomal large subunit biogenesis (GO:0042273) | 2.98935698 |
| 79 | macromolecular complex disassembly (GO:0032984) | 2.98747423 |
| 80 | protein targeting to membrane (GO:0006612) | 2.95895907 |
| 81 | C-terminal protein lipidation (GO:0006501) | 2.94337180 |
| 82 | cellular component biogenesis (GO:0044085) | 2.90732336 |
| 83 | proteasome assembly (GO:0043248) | 2.90377841 |
| 84 | regulation of hypersensitivity (GO:0002883) | 2.88793047 |
| 85 | spinal cord association neuron differentiation (GO:0021527) | 2.88714956 |
| 86 | positive regulation of fatty acid transport (GO:2000193) | 2.83803954 |
| 87 | protein localization to mitochondrion (GO:0070585) | 2.82892712 |
| 88 | protein prenylation (GO:0018342) | 2.81484846 |
| 89 | prenylation (GO:0097354) | 2.81484846 |
| 90 | microtubule severing (GO:0051013) | 2.79193033 |
| 91 | forebrain morphogenesis (GO:0048853) | 2.78382688 |
| 92 | mitochondrial transport (GO:0006839) | 2.76406004 |
| 93 | regulation of prostaglandin secretion (GO:0032306) | 2.73588054 |
| 94 | short-chain fatty acid metabolic process (GO:0046459) | 2.72748704 |
| 95 | somite development (GO:0061053) | 2.72467559 |
| 96 | intracellular protein transmembrane transport (GO:0065002) | 2.72058264 |
| 97 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.71002722 |
| 98 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.71002722 |
| 99 | dopamine transport (GO:0015872) | 2.70748005 |
| 100 | lactate metabolic process (GO:0006089) | 2.66024232 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.68508620 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.42295684 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.00298477 |
| 4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.66140183 |
| 5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.59073148 |
| 6 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.52432625 |
| 7 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.41404647 |
| 8 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.39424422 |
| 9 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.33750198 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.19855182 |
| 11 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.12458025 |
| 12 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.08158401 |
| 13 | VDR_22108803_ChIP-Seq_LS180_Human | 2.05564311 |
| 14 | EWS_26573619_Chip-Seq_HEK293_Human | 2.03870300 |
| 15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.97151167 |
| 16 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.93727601 |
| 17 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.92796894 |
| 18 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.91368296 |
| 19 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.88589280 |
| 20 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.83211963 |
| 21 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.83016936 |
| 22 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.79890017 |
| 23 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.79857436 |
| 24 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.77046962 |
| 25 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.69623125 |
| 26 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.69108936 |
| 27 | P300_19829295_ChIP-Seq_ESCs_Human | 1.64621521 |
| 28 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.63966514 |
| 29 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.62709097 |
| 30 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.61814767 |
| 31 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.61085408 |
| 32 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.60501699 |
| 33 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.55741701 |
| 34 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.54449627 |
| 35 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.53139306 |
| 36 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.47782212 |
| 37 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.47661930 |
| 38 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.46862473 |
| 39 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.44139849 |
| 40 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.42615393 |
| 41 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.41788864 |
| 42 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.41360471 |
| 43 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.40595730 |
| 44 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.39547905 |
| 45 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.38751374 |
| 46 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.38661234 |
| 47 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.37676955 |
| 48 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.35587974 |
| 49 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.35514152 |
| 50 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.35034451 |
| 51 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.34610428 |
| 52 | FUS_26573619_Chip-Seq_HEK293_Human | 1.32791134 |
| 53 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.29931270 |
| 54 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.29911031 |
| 55 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.29824345 |
| 56 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.29048372 |
| 57 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.28056206 |
| 58 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.28056206 |
| 59 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.25122390 |
| 60 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.24869317 |
| 61 | NCOR_22424771_ChIP-Seq_293T_Human | 1.18765988 |
| 62 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.18380024 |
| 63 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.15751906 |
| 64 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.15252681 |
| 65 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.14368178 |
| 66 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.13835335 |
| 67 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.13632587 |
| 68 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.13592789 |
| 69 | AR_25329375_ChIP-Seq_VCAP_Human | 1.12796647 |
| 70 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.11017239 |
| 71 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.11017239 |
| 72 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.10585243 |
| 73 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.09877406 |
| 74 | AR_20517297_ChIP-Seq_VCAP_Human | 1.08652222 |
| 75 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.07905437 |
| 76 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.07893009 |
| 77 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.07237392 |
| 78 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.06836680 |
| 79 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.04485475 |
| 80 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.04449129 |
| 81 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.04438670 |
| 82 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.03811754 |
| 83 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.03560331 |
| 84 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.01647313 |
| 85 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.00724765 |
| 86 | ERA_21632823_ChIP-Seq_H3396_Human | 1.00514465 |
| 87 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.00153135 |
| 88 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.99860873 |
| 89 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.99185338 |
| 90 | REST_21632747_ChIP-Seq_MESCs_Mouse | 0.98309635 |
| 91 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.97137337 |
| 92 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.96077130 |
| 93 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.95842448 |
| 94 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.95441702 |
| 95 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.94040421 |
| 96 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.93853825 |
| 97 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.93309613 |
| 98 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.93161302 |
| 99 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.92591016 |
| 100 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.92435475 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000372_irregular_coat_pigmentation | 4.11630096 |
| 2 | MP0008789_abnormal_olfactory_epithelium | 3.79376646 |
| 3 | MP0006292_abnormal_olfactory_placode | 3.76978657 |
| 4 | MP0009379_abnormal_foot_pigmentation | 3.40574909 |
| 5 | MP0002822_catalepsy | 3.19187020 |
| 6 | MP0005499_abnormal_olfactory_system | 2.85786895 |
| 7 | MP0005394_taste/olfaction_phenotype | 2.85786895 |
| 8 | MP0001188_hyperpigmentation | 2.64337573 |
| 9 | MP0003787_abnormal_imprinting | 2.50256517 |
| 10 | MP0001529_abnormal_vocalization | 2.45859319 |
| 11 | MP0002163_abnormal_gland_morphology | 2.44192884 |
| 12 | MP0004885_abnormal_endolymph | 2.37321744 |
| 13 | MP0006276_abnormal_autonomic_nervous | 2.32224238 |
| 14 | MP0004142_abnormal_muscle_tone | 2.23144884 |
| 15 | MP0004147_increased_porphyrin_level | 2.22865760 |
| 16 | MP0008877_abnormal_DNA_methylation | 2.07557670 |
| 17 | MP0006072_abnormal_retinal_apoptosis | 2.04764279 |
| 18 | MP0005171_absent_coat_pigmentation | 2.03005489 |
| 19 | MP0003880_abnormal_central_pattern | 1.99090585 |
| 20 | MP0005423_abnormal_somatic_nervous | 1.94420089 |
| 21 | MP0003122_maternal_imprinting | 1.84524448 |
| 22 | MP0003646_muscle_fatigue | 1.79174887 |
| 23 | MP0003806_abnormal_nucleotide_metabolis | 1.77079630 |
| 24 | MP0009046_muscle_twitch | 1.70430374 |
| 25 | MP0008995_early_reproductive_senescence | 1.69352702 |
| 26 | MP0000631_abnormal_neuroendocrine_gland | 1.64170823 |
| 27 | MP0000049_abnormal_middle_ear | 1.63771923 |
| 28 | MP0003121_genomic_imprinting | 1.63338977 |
| 29 | MP0005646_abnormal_pituitary_gland | 1.54735955 |
| 30 | MP0005085_abnormal_gallbladder_physiolo | 1.53315589 |
| 31 | MP0001919_abnormal_reproductive_system | 1.53302014 |
| 32 | MP0005389_reproductive_system_phenotype | 1.50108599 |
| 33 | MP0003186_abnormal_redox_activity | 1.50053257 |
| 34 | MP0001905_abnormal_dopamine_level | 1.49626215 |
| 35 | MP0008872_abnormal_physiological_respon | 1.49619884 |
| 36 | MP0002837_dystrophic_cardiac_calcinosis | 1.47336089 |
| 37 | MP0001293_anophthalmia | 1.43443198 |
| 38 | MP0003195_calcinosis | 1.40560306 |
| 39 | MP0003136_yellow_coat_color | 1.33991504 |
| 40 | MP0005645_abnormal_hypothalamus_physiol | 1.28842058 |
| 41 | MP0005379_endocrine/exocrine_gland_phen | 1.28414646 |
| 42 | MP0002638_abnormal_pupillary_reflex | 1.26761524 |
| 43 | MP0001485_abnormal_pinna_reflex | 1.26127483 |
| 44 | MP0002653_abnormal_ependyma_morphology | 1.23809993 |
| 45 | MP0003123_paternal_imprinting | 1.22679408 |
| 46 | MP0006036_abnormal_mitochondrial_physio | 1.22000319 |
| 47 | MP0005084_abnormal_gallbladder_morpholo | 1.18548818 |
| 48 | MP0002160_abnormal_reproductive_system | 1.14116271 |
| 49 | MP0002233_abnormal_nose_morphology | 1.13712285 |
| 50 | MP0009745_abnormal_behavioral_response | 1.12800324 |
| 51 | MP0003137_abnormal_impulse_conducting | 1.10986875 |
| 52 | MP0005551_abnormal_eye_electrophysiolog | 1.10416803 |
| 53 | MP0003786_premature_aging | 1.09368785 |
| 54 | MP0004085_abnormal_heartbeat | 1.05768465 |
| 55 | MP0005253_abnormal_eye_physiology | 1.04200518 |
| 56 | MP0002102_abnormal_ear_morphology | 1.04138164 |
| 57 | MP0002572_abnormal_emotion/affect_behav | 1.03461903 |
| 58 | MP0002557_abnormal_social/conspecific_i | 1.03073239 |
| 59 | MP0004133_heterotaxia | 1.02620472 |
| 60 | MP0005503_abnormal_tendon_morphology | 0.97914445 |
| 61 | MP0001963_abnormal_hearing_physiology | 0.97838173 |
| 62 | MP0002095_abnormal_skin_pigmentation | 0.95934651 |
| 63 | MP0001486_abnormal_startle_reflex | 0.95873932 |
| 64 | MP0000026_abnormal_inner_ear | 0.94404209 |
| 65 | MP0009697_abnormal_copulation | 0.94128127 |
| 66 | MP0005187_abnormal_penis_morphology | 0.92828742 |
| 67 | MP0002272_abnormal_nervous_system | 0.90811336 |
| 68 | MP0001440_abnormal_grooming_behavior | 0.89629559 |
| 69 | MP0003011_delayed_dark_adaptation | 0.89035509 |
| 70 | MP0001968_abnormal_touch/_nociception | 0.86089264 |
| 71 | MP0003941_abnormal_skin_development | 0.85805708 |
| 72 | MP0002751_abnormal_autonomic_nervous | 0.85487400 |
| 73 | MP0002234_abnormal_pharynx_morphology | 0.85011231 |
| 74 | MP0000749_muscle_degeneration | 0.83435415 |
| 75 | MP0000639_abnormal_adrenal_gland | 0.83417909 |
| 76 | MP0000681_abnormal_thyroid_gland | 0.83135708 |
| 77 | MP0005220_abnormal_exocrine_pancreas | 0.82000963 |
| 78 | MP0003724_increased_susceptibility_to | 0.81958456 |
| 79 | MP0000647_abnormal_sebaceous_gland | 0.80243039 |
| 80 | MP0000230_abnormal_systemic_arterial | 0.80073378 |
| 81 | MP0001970_abnormal_pain_threshold | 0.79724349 |
| 82 | MP0002938_white_spotting | 0.78252081 |
| 83 | MP0005195_abnormal_posterior_eye | 0.78121136 |
| 84 | MP0001986_abnormal_taste_sensitivity | 0.77780347 |
| 85 | MP0003119_abnormal_digestive_system | 0.77371959 |
| 86 | MP0004381_abnormal_hair_follicle | 0.77141149 |
| 87 | MP0004742_abnormal_vestibular_system | 0.74876146 |
| 88 | MP0002735_abnormal_chemical_nociception | 0.72996609 |
| 89 | MP0002752_abnormal_somatic_nervous | 0.70879233 |
| 90 | MP0002064_seizures | 0.70524698 |
| 91 | MP0002184_abnormal_innervation | 0.69831609 |
| 92 | MP0005636_abnormal_mineral_homeostasis | 0.69003946 |
| 93 | MP0002734_abnormal_mechanical_nocicepti | 0.68737152 |
| 94 | MP0001727_abnormal_embryo_implantation | 0.67867286 |
| 95 | MP0003567_abnormal_fetal_cardiomyocyte | 0.67465348 |
| 96 | MP0004145_abnormal_muscle_electrophysio | 0.66510374 |
| 97 | MP0001764_abnormal_homeostasis | 0.64871400 |
| 98 | MP0005075_abnormal_melanosome_morpholog | 0.64163374 |
| 99 | MP0003937_abnormal_limbs/digits/tail_de | 0.64131250 |
| 100 | MP0003938_abnormal_ear_development | 0.63601253 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.35870808 |
| 2 | 3-Methylglutaconic aciduria (HP:0003535) | 5.24928637 |
| 3 | Acute encephalopathy (HP:0006846) | 5.24308351 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.84709384 |
| 5 | Mitochondrial inheritance (HP:0001427) | 4.75352281 |
| 6 | Lipid accumulation in hepatocytes (HP:0006561) | 4.66621060 |
| 7 | Progressive macrocephaly (HP:0004481) | 4.57106830 |
| 8 | Abnormal hemoglobin (HP:0011902) | 4.31910157 |
| 9 | Increased CSF lactate (HP:0002490) | 4.27096087 |
| 10 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 4.19787799 |
| 11 | Increased hepatocellular lipid droplets (HP:0006565) | 4.12982958 |
| 12 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.01838964 |
| 13 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.01838964 |
| 14 | Increased intramyocellular lipid droplets (HP:0012240) | 3.62393698 |
| 15 | Renal Fanconi syndrome (HP:0001994) | 3.59175780 |
| 16 | Increased muscle lipid content (HP:0009058) | 3.57283914 |
| 17 | Cerebral edema (HP:0002181) | 3.54531375 |
| 18 | Hypothermia (HP:0002045) | 3.50664752 |
| 19 | Methylmalonic acidemia (HP:0002912) | 3.49686297 |
| 20 | Hepatocellular necrosis (HP:0001404) | 3.46914286 |
| 21 | Decreased central vision (HP:0007663) | 3.31604038 |
| 22 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 3.24421150 |
| 23 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 3.24421150 |
| 24 | Delayed CNS myelination (HP:0002188) | 3.13462351 |
| 25 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.05836256 |
| 26 | Pallor (HP:0000980) | 3.00209401 |
| 27 | Hepatic necrosis (HP:0002605) | 2.96987652 |
| 28 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.66270112 |
| 29 | Exertional dyspnea (HP:0002875) | 2.64778811 |
| 30 | Abnormality of midbrain morphology (HP:0002418) | 2.63546533 |
| 31 | Molar tooth sign on MRI (HP:0002419) | 2.63546533 |
| 32 | Stenosis of the external auditory canal (HP:0000402) | 2.59877791 |
| 33 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.54330272 |
| 34 | Abnormality of renal resorption (HP:0011038) | 2.54058114 |
| 35 | Congenital primary aphakia (HP:0007707) | 2.51630632 |
| 36 | Nephrogenic diabetes insipidus (HP:0009806) | 2.50762693 |
| 37 | Gait imbalance (HP:0002141) | 2.45061336 |
| 38 | Nephronophthisis (HP:0000090) | 2.44965665 |
| 39 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.42124760 |
| 40 | Medial flaring of the eyebrow (HP:0010747) | 2.41934437 |
| 41 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.40171187 |
| 42 | Lactic acidosis (HP:0003128) | 2.39913805 |
| 43 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.39115507 |
| 44 | Increased serum lactate (HP:0002151) | 2.38010410 |
| 45 | True hermaphroditism (HP:0010459) | 2.37391867 |
| 46 | Pancreatic fibrosis (HP:0100732) | 2.37303154 |
| 47 | Respiratory difficulties (HP:0002880) | 2.36795524 |
| 48 | Exercise intolerance (HP:0003546) | 2.34624015 |
| 49 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.33968347 |
| 50 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.33546103 |
| 51 | Optic disc pallor (HP:0000543) | 2.31163591 |
| 52 | Pancreatic cysts (HP:0001737) | 2.30950371 |
| 53 | Pendular nystagmus (HP:0012043) | 2.29669232 |
| 54 | Methylmalonic aciduria (HP:0012120) | 2.29215121 |
| 55 | Respiratory failure (HP:0002878) | 2.27992194 |
| 56 | Congenital, generalized hypertrichosis (HP:0004540) | 2.25368853 |
| 57 | Abnormality of the corticospinal tract (HP:0002492) | 2.24211821 |
| 58 | Leukodystrophy (HP:0002415) | 2.16190823 |
| 59 | Agitation (HP:0000713) | 2.14686411 |
| 60 | Thyroid-stimulating hormone excess (HP:0002925) | 2.13924770 |
| 61 | Hyperglycinemia (HP:0002154) | 2.05283342 |
| 62 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.99732235 |
| 63 | Macrocytic anemia (HP:0001972) | 1.96070686 |
| 64 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.95549735 |
| 65 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.95549735 |
| 66 | Intestinal atresia (HP:0011100) | 1.95528819 |
| 67 | Abnormality of the renal medulla (HP:0100957) | 1.94157634 |
| 68 | Decreased subcutaneous fat (HP:0001002) | 1.93388017 |
| 69 | Adrenal hypoplasia (HP:0000835) | 1.92927772 |
| 70 | Abnormality of lateral ventricle (HP:0030047) | 1.92403062 |
| 71 | Abnormality of urine glucose concentration (HP:0011016) | 1.92015939 |
| 72 | Glycosuria (HP:0003076) | 1.92015939 |
| 73 | CNS demyelination (HP:0007305) | 1.91232067 |
| 74 | Azoospermia (HP:0000027) | 1.87364583 |
| 75 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.86097772 |
| 76 | Epileptic encephalopathy (HP:0200134) | 1.85407221 |
| 77 | Abnormality of the anterior horn cell (HP:0006802) | 1.85397502 |
| 78 | Degeneration of anterior horn cells (HP:0002398) | 1.85397502 |
| 79 | Constricted visual fields (HP:0001133) | 1.85372431 |
| 80 | Hyperphosphaturia (HP:0003109) | 1.83752671 |
| 81 | Genital tract atresia (HP:0001827) | 1.83400110 |
| 82 | Vaginal atresia (HP:0000148) | 1.82855175 |
| 83 | Chronic hepatic failure (HP:0100626) | 1.82782573 |
| 84 | X-linked dominant inheritance (HP:0001423) | 1.82738412 |
| 85 | Hypoplasia of the uterus (HP:0000013) | 1.81953080 |
| 86 | Abnormality of vitamin B metabolism (HP:0004340) | 1.81256242 |
| 87 | Concave nail (HP:0001598) | 1.80133035 |
| 88 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.79375081 |
| 89 | Lethargy (HP:0001254) | 1.79260664 |
| 90 | Supernumerary spleens (HP:0009799) | 1.79201154 |
| 91 | Abnormal ciliary motility (HP:0012262) | 1.79016169 |
| 92 | Abnormal number of erythroid precursors (HP:0012131) | 1.77730339 |
| 93 | Abolished electroretinogram (ERG) (HP:0000550) | 1.74445476 |
| 94 | Erythroderma (HP:0001019) | 1.72361715 |
| 95 | Growth hormone deficiency (HP:0000824) | 1.72237099 |
| 96 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.72097499 |
| 97 | Sclerocornea (HP:0000647) | 1.69980092 |
| 98 | Large eyes (HP:0001090) | 1.69939779 |
| 99 | Split foot (HP:0001839) | 1.69561959 |
| 100 | Reticulocytopenia (HP:0001896) | 1.68315739 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | AKT3 | 5.17069549 |
| 2 | MAP3K12 | 3.37275154 |
| 3 | PINK1 | 3.07891964 |
| 4 | MAP4K2 | 2.97972810 |
| 5 | NME2 | 2.81089492 |
| 6 | BRAF | 2.31189725 |
| 7 | GRK1 | 2.29922150 |
| 8 | TLK1 | 2.20104708 |
| 9 | BMPR2 | 2.12012577 |
| 10 | MYLK | 1.81426942 |
| 11 | SRPK1 | 1.80355291 |
| 12 | CSNK1G3 | 1.79838194 |
| 13 | FRK | 1.74103592 |
| 14 | BUB1 | 1.73504645 |
| 15 | CSNK1G2 | 1.71871851 |
| 16 | CDK19 | 1.71607412 |
| 17 | PIK3CA | 1.61023306 |
| 18 | SCYL2 | 1.55043780 |
| 19 | CSNK1G1 | 1.52902793 |
| 20 | NEK1 | 1.52084921 |
| 21 | BCKDK | 1.47258618 |
| 22 | PLK4 | 1.40223419 |
| 23 | CSNK1A1L | 1.38031176 |
| 24 | DYRK2 | 1.25048882 |
| 25 | BRSK1 | 1.18996066 |
| 26 | ZAK | 1.18625230 |
| 27 | ADRBK2 | 1.14455580 |
| 28 | TAOK3 | 1.10137253 |
| 29 | ERBB3 | 1.09828127 |
| 30 | TNK2 | 1.08237227 |
| 31 | PLK2 | 1.03492562 |
| 32 | PHKG2 | 1.02406728 |
| 33 | PHKG1 | 1.02406728 |
| 34 | TRIM28 | 1.01015330 |
| 35 | AURKB | 0.98988213 |
| 36 | VRK2 | 0.98226652 |
| 37 | INSRR | 0.97675674 |
| 38 | RPS6KA4 | 0.94946791 |
| 39 | DAPK3 | 0.94159852 |
| 40 | LMTK2 | 0.93336216 |
| 41 | WNK3 | 0.92254830 |
| 42 | ILK | 0.90527549 |
| 43 | WNK4 | 0.90490927 |
| 44 | WEE1 | 0.87996732 |
| 45 | LIMK1 | 0.87600927 |
| 46 | DYRK3 | 0.86824084 |
| 47 | BCR | 0.85986650 |
| 48 | STK11 | 0.84377526 |
| 49 | BMPR1B | 0.83671997 |
| 50 | CDC7 | 0.80057662 |
| 51 | NEK2 | 0.79498612 |
| 52 | ERBB4 | 0.77146622 |
| 53 | CAMKK2 | 0.76302677 |
| 54 | AURKA | 0.76038334 |
| 55 | CCNB1 | 0.73763783 |
| 56 | STK16 | 0.72423764 |
| 57 | NME1 | 0.72333556 |
| 58 | OBSCN | 0.70902317 |
| 59 | BRSK2 | 0.68675342 |
| 60 | PRKACA | 0.67857987 |
| 61 | CSNK2A1 | 0.66119939 |
| 62 | MINK1 | 0.65452592 |
| 63 | SGK494 | 0.63545768 |
| 64 | SGK223 | 0.63545768 |
| 65 | CSNK2A2 | 0.61342891 |
| 66 | VRK1 | 0.59041542 |
| 67 | PRKCG | 0.57025162 |
| 68 | PAK4 | 0.56147301 |
| 69 | DAPK1 | 0.55603930 |
| 70 | CDK3 | 0.54610875 |
| 71 | CSNK1A1 | 0.52670816 |
| 72 | ERBB2 | 0.52472912 |
| 73 | BTK | 0.51620578 |
| 74 | PLK1 | 0.51460186 |
| 75 | PDK2 | 0.50819107 |
| 76 | ADRBK1 | 0.50700223 |
| 77 | PRKG1 | 0.49056270 |
| 78 | CAMK2D | 0.49001285 |
| 79 | CASK | 0.48438059 |
| 80 | DAPK2 | 0.48085667 |
| 81 | SGK2 | 0.47509736 |
| 82 | PAK1 | 0.47140752 |
| 83 | EPHB2 | 0.46940896 |
| 84 | NUAK1 | 0.46760795 |
| 85 | PIM2 | 0.46256968 |
| 86 | CAMK2A | 0.45592467 |
| 87 | CSNK1E | 0.45095599 |
| 88 | ROCK1 | 0.44689542 |
| 89 | PRKCE | 0.43792540 |
| 90 | RPS6KA5 | 0.43235024 |
| 91 | PLK3 | 0.42950864 |
| 92 | ATR | 0.42157285 |
| 93 | CAMK1 | 0.41787776 |
| 94 | MAPKAPK5 | 0.41720624 |
| 95 | ARAF | 0.41330957 |
| 96 | EGFR | 0.39502803 |
| 97 | PAK3 | 0.38996417 |
| 98 | WNK1 | 0.38479594 |
| 99 | MAPK15 | 0.37589458 |
| 100 | PRKACB | 0.36857659 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.67026950 |
| 2 | Parkinsons disease_Homo sapiens_hsa05012 | 4.87395640 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 4.38179105 |
| 4 | Alzheimers disease_Homo sapiens_hsa05010 | 3.43824934 |
| 5 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 3.43099209 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.29821718 |
| 7 | Protein export_Homo sapiens_hsa03060 | 3.27033104 |
| 8 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 3.14477044 |
| 9 | Proteasome_Homo sapiens_hsa03050 | 3.00728399 |
| 10 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.78298886 |
| 11 | Asthma_Homo sapiens_hsa05310 | 2.05843395 |
| 12 | RNA polymerase_Homo sapiens_hsa03020 | 1.92971535 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 1.91265424 |
| 14 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.77240997 |
| 15 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.51313562 |
| 16 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.40210530 |
| 17 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.40187961 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.25518761 |
| 19 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.22013462 |
| 20 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.19055388 |
| 21 | Olfactory transduction_Homo sapiens_hsa04740 | 1.15590981 |
| 22 | Peroxisome_Homo sapiens_hsa04146 | 1.13504794 |
| 23 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.11441191 |
| 24 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.03877647 |
| 25 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.01595994 |
| 26 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.99926300 |
| 27 | Phototransduction_Homo sapiens_hsa04744 | 0.99713397 |
| 28 | RNA degradation_Homo sapiens_hsa03018 | 0.99100138 |
| 29 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.96525563 |
| 30 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.95732966 |
| 31 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.92169161 |
| 32 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.89676681 |
| 33 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.87501777 |
| 34 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.83859374 |
| 35 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.82285488 |
| 36 | Base excision repair_Homo sapiens_hsa03410 | 0.81464550 |
| 37 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.79606229 |
| 38 | Metabolic pathways_Homo sapiens_hsa01100 | 0.78553669 |
| 39 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.77811518 |
| 40 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.77535788 |
| 41 | Mismatch repair_Homo sapiens_hsa03430 | 0.77136436 |
| 42 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.76617535 |
| 43 | DNA replication_Homo sapiens_hsa03030 | 0.75177359 |
| 44 | Spliceosome_Homo sapiens_hsa03040 | 0.75092516 |
| 45 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.74256447 |
| 46 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.73434694 |
| 47 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.71799976 |
| 48 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.70343517 |
| 49 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.69508691 |
| 50 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.66205265 |
| 51 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.64348063 |
| 52 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.63538316 |
| 53 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.63434588 |
| 54 | Retinol metabolism_Homo sapiens_hsa00830 | 0.63327574 |
| 55 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.61485627 |
| 56 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.60970961 |
| 57 | Nicotine addiction_Homo sapiens_hsa05033 | 0.58949294 |
| 58 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.57311523 |
| 59 | Purine metabolism_Homo sapiens_hsa00230 | 0.57026510 |
| 60 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.53887241 |
| 61 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.53842203 |
| 62 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.52106457 |
| 63 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.49648607 |
| 64 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.49402768 |
| 65 | Morphine addiction_Homo sapiens_hsa05032 | 0.48760469 |
| 66 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.48253248 |
| 67 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.48072354 |
| 68 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.47071120 |
| 69 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.46788923 |
| 70 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.44671784 |
| 71 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.43861344 |
| 72 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.43534731 |
| 73 | Insulin secretion_Homo sapiens_hsa04911 | 0.42440453 |
| 74 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.41749718 |
| 75 | GABAergic synapse_Homo sapiens_hsa04727 | 0.39949928 |
| 76 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.38631616 |
| 77 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.38355638 |
| 78 | RNA transport_Homo sapiens_hsa03013 | 0.37227677 |
| 79 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.37167066 |
| 80 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.34804837 |
| 81 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.34315616 |
| 82 | Taste transduction_Homo sapiens_hsa04742 | 0.34069419 |
| 83 | Sulfur relay system_Homo sapiens_hsa04122 | 0.33508127 |
| 84 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.32032376 |
| 85 | Malaria_Homo sapiens_hsa05144 | 0.31975223 |
| 86 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.30680323 |
| 87 | Mineral absorption_Homo sapiens_hsa04978 | 0.27903901 |
| 88 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.26684345 |
| 89 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.26325795 |
| 90 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.25565499 |
| 91 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.24928541 |
| 92 | Allograft rejection_Homo sapiens_hsa05330 | 0.24677836 |
| 93 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.24193774 |
| 94 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.23465615 |
| 95 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.22993526 |
| 96 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.22931783 |
| 97 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.22093241 |
| 98 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.21446659 |
| 99 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.21380804 |
| 100 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.20964865 |

