SHISA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.57124177
2regulation of cardioblast proliferation (GO:0003264)6.21291021
3regulation of secondary heart field cardioblast proliferation (GO:0003266)6.21291021
4outer ear morphogenesis (GO:0042473)5.81079060
5middle ear morphogenesis (GO:0042474)5.25545560
6regulation of skeletal muscle contraction (GO:0014819)5.21037618
7actin-myosin filament sliding (GO:0033275)5.19249806
8muscle filament sliding (GO:0030049)5.19249806
9negative regulation of keratinocyte proliferation (GO:0010839)4.91848736
10DNA double-strand break processing (GO:0000729)4.90984506
11actin-mediated cell contraction (GO:0070252)4.75507275
12planar cell polarity pathway involved in neural tube closure (GO:0090179)4.68960679
13skeletal muscle fiber development (GO:0048741)4.54297271
14lateral sprouting from an epithelium (GO:0060601)4.53227653
15regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.51285427
16skeletal muscle contraction (GO:0003009)4.44521529
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.35827969
18limb bud formation (GO:0060174)4.33063138
19G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.31003480
20desmosome organization (GO:0002934)4.30154865
21regulation of heart morphogenesis (GO:2000826)4.30153179
22replication fork processing (GO:0031297)4.20925075
23embryonic viscerocranium morphogenesis (GO:0048703)4.18496554
24regulation of transforming growth factor beta2 production (GO:0032909)4.08977714
25chromatin remodeling at centromere (GO:0031055)4.08627004
26negative regulation of cell fate commitment (GO:0010454)4.06217155
27cochlea morphogenesis (GO:0090103)3.98884979
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.83705132
29histone exchange (GO:0043486)3.81355107
30CENP-A containing nucleosome assembly (GO:0034080)3.75449788
31myotube cell development (GO:0014904)3.75265376
32actin filament-based movement (GO:0030048)3.70193238
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.66176913
34somatic diversification of immune receptors via somatic mutation (GO:0002566)3.66176913
35pharyngeal system development (GO:0060037)3.64564056
36cellular response to vitamin (GO:0071295)3.63439245
37somite development (GO:0061053)3.60588499
38plasma membrane repair (GO:0001778)3.58055671
39dorsal/ventral axis specification (GO:0009950)3.56155104
40negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.54287542
41negative regulation of translation, ncRNA-mediated (GO:0040033)3.54287542
42regulation of translation, ncRNA-mediated (GO:0045974)3.54287542
43kinetochore assembly (GO:0051382)3.53636072
44cellular response to vitamin D (GO:0071305)3.53531133
45response to inactivity (GO:0014854)3.53189639
46muscle cell fate commitment (GO:0042693)3.51449729
47positive regulation of gastrulation (GO:2000543)3.51189043
48DNA replication checkpoint (GO:0000076)3.46858449
49kinetochore organization (GO:0051383)3.45268688
50embryonic cranial skeleton morphogenesis (GO:0048701)3.45218581
51neural tube formation (GO:0001841)3.40844177
52kidney morphogenesis (GO:0060993)3.39765476
53notochord development (GO:0030903)3.38128088
54skeletal muscle adaptation (GO:0043501)3.36089777
55non-canonical Wnt signaling pathway (GO:0035567)3.35818706
56regulation of nuclear cell cycle DNA replication (GO:0033262)3.35677454
57maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.34888567
58regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.34182834
59regulation of mitotic spindle checkpoint (GO:1903504)3.34182834
60striated muscle atrophy (GO:0014891)3.33112509
61paraxial mesoderm development (GO:0048339)3.31070388
62nephron tubule formation (GO:0072079)3.30969431
63collecting duct development (GO:0072044)3.30857221
64regulation of keratinocyte proliferation (GO:0010837)3.30323114
65morphogenesis of an epithelial fold (GO:0060571)3.28780470
66positive regulation of myoblast differentiation (GO:0045663)3.28108730
67anterior/posterior axis specification, embryo (GO:0008595)3.26384853
68mitotic sister chromatid cohesion (GO:0007064)3.25680090
69mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.25288998
70response to muscle activity (GO:0014850)3.21648989
71negative regulation of chondrocyte differentiation (GO:0032331)3.20532994
72mitotic metaphase plate congression (GO:0007080)3.20002364
73positive regulation of embryonic development (GO:0040019)3.19810225
74proteasome assembly (GO:0043248)3.19013707
75regulation of meiosis I (GO:0060631)3.17386230
76myoblast migration (GO:0051451)3.16960984
77Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.16406986
78regulation of skeletal muscle cell differentiation (GO:2001014)3.15592097
79bundle of His cell to Purkinje myocyte communication (GO:0086069)3.15312822
80positive regulation of male gonad development (GO:2000020)3.14967448
81cullin deneddylation (GO:0010388)3.14560741
82response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.13095426
83positive regulation of hormone biosynthetic process (GO:0046886)3.10711486
84response to X-ray (GO:0010165)3.08660273
85regulation of timing of cell differentiation (GO:0048505)3.06616032
86aorta morphogenesis (GO:0035909)3.05511328
87glial cell proliferation (GO:0014009)3.05349364
88cornea development in camera-type eye (GO:0061303)3.04783971
89spindle checkpoint (GO:0031577)3.04188998
90segment specification (GO:0007379)3.04138270
91metaphase plate congression (GO:0051310)3.03582454
92regulation of establishment of planar polarity (GO:0090175)3.02872019
93sarcomere organization (GO:0045214)3.02852451
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02026965
95muscle cell cellular homeostasis (GO:0046716)3.01273672
96regulation of mesoderm development (GO:2000380)3.00890411
97regulation of DNA endoreduplication (GO:0032875)3.00725067
98cell-substrate junction assembly (GO:0007044)2.99243196
99epithelial cell fate commitment (GO:0072148)2.99136073
100positive regulation of mesenchymal cell proliferation (GO:0002053)2.97920812
101keratinocyte proliferation (GO:0043616)2.97780154
102negative regulation of cell fate specification (GO:0009996)2.97651684
103protein K6-linked ubiquitination (GO:0085020)2.97452456
104keratinocyte development (GO:0003334)2.97241628
105negative regulation of cartilage development (GO:0061037)2.96720917
106negative regulation of transcription regulatory region DNA binding (GO:2000678)2.96536277
107response to pheromone (GO:0019236)2.93819782
108DNA replication-independent nucleosome assembly (GO:0006336)2.93733993
109DNA replication-independent nucleosome organization (GO:0034724)2.93733993
110retinal ganglion cell axon guidance (GO:0031290)2.93646064
111sarcoplasmic reticulum calcium ion transport (GO:0070296)2.93511118
112non-recombinational repair (GO:0000726)2.93326602
113double-strand break repair via nonhomologous end joining (GO:0006303)2.93326602
114mesenchymal to epithelial transition (GO:0060231)2.92486182
115embryonic skeletal joint morphogenesis (GO:0060272)2.91849983
116regulation of mesenchymal cell apoptotic process (GO:2001053)2.91082364
117negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.90681822
118myoblast fusion (GO:0007520)2.90482324
119protein localization to kinetochore (GO:0034501)2.89354471
120hippo signaling (GO:0035329)2.89168441
121olfactory bulb development (GO:0021772)2.88376433
122resolution of meiotic recombination intermediates (GO:0000712)2.88210209
123DNA ligation (GO:0006266)2.85630942
124regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.85067570
125positive regulation of myotube differentiation (GO:0010831)2.85007638
126muscle atrophy (GO:0014889)2.84846985
127DNA catabolic process, exonucleolytic (GO:0000738)2.83904661
128striated muscle contraction (GO:0006941)2.82692805
129cranial nerve morphogenesis (GO:0021602)2.82562943
130regulation of cell fate specification (GO:0042659)2.81792998
131regulation of male gonad development (GO:2000018)2.81784173
132recombinational repair (GO:0000725)2.81659219
133endocardial cushion morphogenesis (GO:0003203)2.81540186
134muscle fiber development (GO:0048747)2.80857509
135double-strand break repair via homologous recombination (GO:0000724)2.80654095
136somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80231144
137somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80231144
138isotype switching (GO:0045190)2.80231144
139protein deneddylation (GO:0000338)2.80173315
140attachment of spindle microtubules to kinetochore (GO:0008608)2.79704355
141negative regulation of DNA recombination (GO:0045910)2.79678878
142myotube differentiation (GO:0014902)2.78784612
143sympathetic nervous system development (GO:0048485)2.76762981
144proximal/distal pattern formation (GO:0009954)2.74198338
145mitotic spindle checkpoint (GO:0071174)2.73514267
146exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73342894
147cardiac right ventricle morphogenesis (GO:0003215)2.72602284
148female gonad development (GO:0008585)2.72417279
149synapsis (GO:0007129)2.72300499
150eye photoreceptor cell differentiation (GO:0001754)2.72266228
151photoreceptor cell differentiation (GO:0046530)2.72266228
152regulation of mesenchymal cell proliferation (GO:0010464)2.72054194
153establishment of planar polarity (GO:0001736)2.71850797
154establishment of tissue polarity (GO:0007164)2.71850797
155skeletal muscle tissue regeneration (GO:0043403)2.71843057
156regulation of development, heterochronic (GO:0040034)2.71455492
157neuron fate determination (GO:0048664)2.71151652
158outflow tract morphogenesis (GO:0003151)2.70764324
159positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.70203576
160regulation of telomere maintenance (GO:0032204)2.69966388
161hair cycle process (GO:0022405)2.69906544
162molting cycle process (GO:0022404)2.69906544
163DNA damage response, detection of DNA damage (GO:0042769)2.69626980
164regulation of helicase activity (GO:0051095)2.69502432
165nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69087398
166regulation of organ formation (GO:0003156)2.67255419
167protein K11-linked deubiquitination (GO:0035871)2.66740674
168negative chemotaxis (GO:0050919)2.64503685
169DNA replication-dependent nucleosome assembly (GO:0006335)2.63647530
170DNA replication-dependent nucleosome organization (GO:0034723)2.63647530
171mitotic G2/M transition checkpoint (GO:0044818)2.63578180
172ganglion development (GO:0061548)2.62222002
173keratinocyte differentiation (GO:0030216)2.61196375
174positive regulation of skeletal muscle tissue development (GO:0048643)2.61141140
175hair follicle morphogenesis (GO:0031069)2.61077694
176regulation of mesonephros development (GO:0061217)2.61003638
177somatic diversification of immunoglobulins (GO:0016445)2.60863716
178regulation of hippo signaling (GO:0035330)2.59756836
179postreplication repair (GO:0006301)2.58827461
180positive regulation of cardiac muscle cell proliferation (GO:0060045)2.55313144
181histone H2A acetylation (GO:0043968)2.55214207
182somatic recombination of immunoglobulin gene segments (GO:0016447)2.55089149
183branched-chain amino acid catabolic process (GO:0009083)2.54796707
184somatic diversification of immune receptors (GO:0002200)2.54404587
185otic vesicle formation (GO:0030916)2.52237437
186regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.51070240
187protein sumoylation (GO:0016925)2.50337842
188protein neddylation (GO:0045116)2.50013868
189somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.49792696
190somatic cell DNA recombination (GO:0016444)2.49792696
191regulation of collateral sprouting (GO:0048670)2.48120986
192negative regulation of sister chromatid segregation (GO:0033046)2.45575911
193negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.45575911
194negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.45575911
195negative regulation of mitotic sister chromatid segregation (GO:0033048)2.45575911
196negative regulation of mitotic sister chromatid separation (GO:2000816)2.45575911
197generation of neurons (GO:0048699)2.44166932
198telomere maintenance via telomerase (GO:0007004)2.42110062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.59612267
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.36491184
3E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93645176
4ZNF274_21170338_ChIP-Seq_K562_Hela2.93045654
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.88659581
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79780736
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.69241323
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.49862309
9FUS_26573619_Chip-Seq_HEK293_Human2.46337041
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46329357
11VDR_22108803_ChIP-Seq_LS180_Human2.44289450
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44142837
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39891816
14E2F7_22180533_ChIP-Seq_HELA_Human2.39128855
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.36594283
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.35555216
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33406943
18EWS_26573619_Chip-Seq_HEK293_Human2.32800489
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.28974350
20IGF1R_20145208_ChIP-Seq_DFB_Human2.27210588
21P300_19829295_ChIP-Seq_ESCs_Human2.26664416
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.23347814
23TP53_20018659_ChIP-ChIP_R1E_Mouse2.21639893
24ESR1_21235772_ChIP-Seq_MCF-7_Human2.21566585
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20503192
26GBX2_23144817_ChIP-Seq_PC3_Human2.18803545
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.12425152
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.07899862
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07101516
30EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07101516
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03853337
32EZH2_27304074_Chip-Seq_ESCs_Mouse2.02267610
33EED_16625203_ChIP-ChIP_MESCs_Mouse2.00288984
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.91835676
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.91379464
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.91272715
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90842963
38ELK1_19687146_ChIP-ChIP_HELA_Human1.87221631
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86755313
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86246552
41AR_21572438_ChIP-Seq_LNCaP_Human1.84119855
42TAF15_26573619_Chip-Seq_HEK293_Human1.81782717
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81734980
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81156536
45* RNF2_27304074_Chip-Seq_ESCs_Mouse1.79914535
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76167525
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73929260
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.72500293
49* ISL1_27105846_Chip-Seq_CPCs_Mouse1.70871080
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70395995
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.70015152
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68551199
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68201473
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68171755
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.67437807
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66325067
57CLOCK_20551151_ChIP-Seq_293T_Human1.64251119
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63430801
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.61477653
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.61211979
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.60514493
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58975933
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58767760
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58667497
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58663037
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57367347
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.56337537
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55907249
69MYC_18940864_ChIP-ChIP_HL60_Human1.53999875
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52619616
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52593223
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.52107966
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51692640
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50981415
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50208654
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49624165
77* SMAD3_21741376_ChIP-Seq_EPCs_Human1.49008834
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47973576
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.46293210
80* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46285272
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45237230
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.45128550
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44995362
84* RING1B_27294783_Chip-Seq_ESCs_Mouse1.43239681
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43093925
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42513494
87* BCAT_22108803_ChIP-Seq_LS180_Human1.42160642
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.41835801
89* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41432714
90* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40435026
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40411967
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39006844
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39006844
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39006844
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36984116
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34942980
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34913965
98* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34876786
99SMAD4_21799915_ChIP-Seq_A2780_Human1.31750209
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30967792
101* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30390494
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30323298
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28577259
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28015059
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27430681
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27007317
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26568047
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26423365
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24892314
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24884053
111* TCF4_22108803_ChIP-Seq_LS180_Human1.24574153
112ER_23166858_ChIP-Seq_MCF-7_Human1.24074006
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23902019
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23670725
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23473179
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23168534
117CBP_20019798_ChIP-Seq_JUKART_Human1.23168534
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23044779
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22053635
120RNF2_27304074_Chip-Seq_NSC_Mouse1.21350678
121* UBF1/2_26484160_Chip-Seq_HMECs_Human1.21240105
122CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20619998
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20250283
124RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20246970
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20225051
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20151638
127TP63_19390658_ChIP-ChIP_HaCaT_Human1.19150723
128* AR_25329375_ChIP-Seq_VCAP_Human1.18595535
129RUNX1_27514584_Chip-Seq_MCF-7_Human1.18486448
130SOX2_19829295_ChIP-Seq_ESCs_Human1.17920747
131NANOG_19829295_ChIP-Seq_ESCs_Human1.17920747
132TBX20_22328084_ChIP-Seq_HEART_Mouse1.16292699
133TBX20_22080862_ChIP-Seq_HEART_Mouse1.16292699
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15305853
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15264352
136EZH2_27294783_Chip-Seq_NPCs_Mouse1.14643234
137SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14460691
138RACK7_27058665_Chip-Seq_MCF-7_Human1.13496828
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13296327
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13296327
141WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13178280
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13162791
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11222143
144NFE2_27457419_Chip-Seq_LIVER_Mouse1.10331301
145E2F1_21310950_ChIP-Seq_MCF-7_Human1.10207452
146KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09962870
147* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09900990
148NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09637156
149KDM2B_26808549_Chip-Seq_K562_Human1.09348967
150SMAD4_21741376_ChIP-Seq_EPCs_Human1.09187790
151SOX9_26525672_Chip-Seq_HEART_Mouse1.09016799
152NANOG_18555785_Chip-Seq_ESCs_Mouse1.08776368
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08130588
154IRF1_19129219_ChIP-ChIP_H3396_Human1.07876340
155SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07829257
156SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07829257
157* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07693093
158* CTCF_27219007_Chip-Seq_Bcells_Human1.07672219
159NOTCH1_21737748_ChIP-Seq_TLL_Human1.07570328
160STAT3_23295773_ChIP-Seq_U87_Human1.06048662
161* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05694312
162CJUN_26792858_Chip-Seq_BT549_Human1.04696389
163JUN_21703547_ChIP-Seq_K562_Human1.02904600
164KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02798784
165FOXP3_21729870_ChIP-Seq_TREG_Human1.01410061
166VDR_23849224_ChIP-Seq_CD4+_Human1.00777000
167KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00231652
168TCF4_23295773_ChIP-Seq_U87_Human1.00127493
169YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99595518
170CRX_20693478_ChIP-Seq_RETINA_Mouse0.99396747
171* RUNX2_22187159_ChIP-Seq_PCA_Human0.99021959
172TP53_18474530_ChIP-ChIP_U2OS_Human0.98853269
173TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97751181
174CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97603805
175EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96817648
176TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95657726
177RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95630352
178TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95558439
179ZNF263_19887448_ChIP-Seq_K562_Human0.95025317
180BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94885879
181* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94634712
182* KDM2B_26808549_Chip-Seq_JURKAT_Human0.93519779
183SMAD3_21741376_ChIP-Seq_HESCs_Human0.92938349
184KLF5_25053715_ChIP-Seq_YYC3_Human0.92375431
185TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91629656
186YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90462774
187TCF4_18268006_ChIP-ChIP_LS174T_Human0.90458033
188CREB1_26743006_Chip-Seq_LNCaP_Human0.89666930
189AHR_22903824_ChIP-Seq_MCF-7_Human0.89154572
190STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88549173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.99966695
2MP0006292_abnormal_olfactory_placode3.64282136
3MP0000537_abnormal_urethra_morphology3.38231358
4MP0004145_abnormal_muscle_electrophysio2.91810085
5MP0001849_ear_inflammation2.85670669
6MP0008058_abnormal_DNA_repair2.84466417
7MP0008877_abnormal_DNA_methylation2.83595491
8MP0010234_abnormal_vibrissa_follicle2.78748210
9MP0003890_abnormal_embryonic-extraembry2.71837467
10MP0003693_abnormal_embryo_hatching2.62470006
11MP0008789_abnormal_olfactory_epithelium2.62023377
12MP0001346_abnormal_lacrimal_gland2.59629087
13MP0002234_abnormal_pharynx_morphology2.51532848
14MP0005367_renal/urinary_system_phenotyp2.44945865
15MP0000516_abnormal_urinary_system2.44945865
16MP0010094_abnormal_chromosome_stability2.44007411
17MP0003941_abnormal_skin_development2.43896044
18MP0000733_abnormal_muscle_development2.41320380
19MP0000762_abnormal_tongue_morphology2.41006198
20MP0000049_abnormal_middle_ear2.40694101
21MP0002102_abnormal_ear_morphology2.35308928
22MP0003136_yellow_coat_color2.28068997
23MP0003880_abnormal_central_pattern2.19480566
24MP0002751_abnormal_autonomic_nervous2.19399782
25MP0003195_calcinosis2.18784242
26MP0000678_abnormal_parathyroid_gland2.17814209
27MP0003705_abnormal_hypodermis_morpholog2.15989491
28MP0002249_abnormal_larynx_morphology2.11293869
29MP0009053_abnormal_anal_canal2.07835478
30MP0002736_abnormal_nociception_after2.06487667
31MP0004133_heterotaxia2.05940728
32MP0009250_abnormal_appendicular_skeleto2.03852389
33MP0002098_abnormal_vibrissa_morphology1.99342066
34MP0000751_myopathy1.93887787
35MP0003121_genomic_imprinting1.92050670
36MP0003755_abnormal_palate_morphology1.91783095
37MP0000372_irregular_coat_pigmentation1.89313633
38MP0003718_maternal_effect1.88305517
39MP0000749_muscle_degeneration1.85829272
40MP0000579_abnormal_nail_morphology1.79005160
41MP0006054_spinal_hemorrhage1.76040345
42MP0005248_abnormal_Harderian_gland1.74777341
43MP0002254_reproductive_system_inflammat1.72309788
44MP0006072_abnormal_retinal_apoptosis1.72168521
45MP0000428_abnormal_craniofacial_morphol1.69537876
46MP0002233_abnormal_nose_morphology1.67913605
47MP0005499_abnormal_olfactory_system1.64372854
48MP0005394_taste/olfaction_phenotype1.64372854
49MP0003567_abnormal_fetal_cardiomyocyte1.62895535
50MP0000383_abnormal_hair_follicle1.62166632
51MP0010678_abnormal_skin_adnexa1.61944361
52MP0003787_abnormal_imprinting1.61471002
53MP0003942_abnormal_urinary_system1.60280846
54MP0001299_abnormal_eye_distance/1.57571978
55MP0001485_abnormal_pinna_reflex1.56663703
56MP0000759_abnormal_skeletal_muscle1.56586084
57MP0003122_maternal_imprinting1.54261967
58MP0002282_abnormal_trachea_morphology1.50481318
59MP0003937_abnormal_limbs/digits/tail_de1.49279621
60MP0004233_abnormal_muscle_weight1.48809329
61MP0003111_abnormal_nucleus_morphology1.48316766
62MP0002108_abnormal_muscle_morphology1.47207600
63MP0001177_atelectasis1.46349933
64MP0008932_abnormal_embryonic_tissue1.46178249
65MP0000750_abnormal_muscle_regeneration1.45921357
66MP0003385_abnormal_body_wall1.45616539
67MP0002106_abnormal_muscle_physiology1.41306612
68MP0000427_abnormal_hair_cycle1.41272133
69MP0008057_abnormal_DNA_replication1.39633931
70MP0004957_abnormal_blastocyst_morpholog1.38887936
71MP0002938_white_spotting1.38083604
72MP0002932_abnormal_joint_morphology1.37765905
73MP0001529_abnormal_vocalization1.37007139
74MP0005508_abnormal_skeleton_morphology1.36786472
75MP0000747_muscle_weakness1.36649811
76MP0000534_abnormal_ureter_morphology1.36358080
77MP0003011_delayed_dark_adaptation1.35812582
78MP0005369_muscle_phenotype1.35726581
79MP0002009_preneoplasia1.33713139
80MP0000377_abnormal_hair_follicle1.33548016
81MP0000778_abnormal_nervous_system1.32131703
82MP0002184_abnormal_innervation1.31603438
83MP0001968_abnormal_touch/_nociception1.30212870
84MP0003935_abnormal_craniofacial_develop1.29926232
85MP0002116_abnormal_craniofacial_bone1.29187594
86MP0002060_abnormal_skin_morphology1.27881975
87MP0002177_abnormal_outer_ear1.26956593
88MP0003315_abnormal_perineum_morphology1.26910547
89MP0004087_abnormal_muscle_fiber1.24316814
90MP0005623_abnormal_meninges_morphology1.24316766
91MP0003119_abnormal_digestive_system1.24269456
92MP0002796_impaired_skin_barrier1.23775401
93MP0005275_abnormal_skin_tensile1.21968696
94MP0005551_abnormal_eye_electrophysiolog1.21736830
95MP0000566_synostosis1.21247242
96MP0005076_abnormal_cell_differentiation1.20522022
97MP0003077_abnormal_cell_cycle1.20286362
98MP0001293_anophthalmia1.18966077
99MP0002269_muscular_atrophy1.18564376
100MP0000163_abnormal_cartilage_morphology1.14779254
101MP0001270_distended_abdomen1.14352909
102MP0005187_abnormal_penis_morphology1.14101259
103MP0001340_abnormal_eyelid_morphology1.13842815
104MP0003950_abnormal_plasma_membrane1.12881814
105MP0000631_abnormal_neuroendocrine_gland1.12582201
106MP0002877_abnormal_melanocyte_morpholog1.11395132
107MP0004147_increased_porphyrin_level1.10968418
108MP0001286_abnormal_eye_development1.09262134
109MP0000432_abnormal_head_morphology1.08448316
110MP0000467_abnormal_esophagus_morphology1.07698598
111MP0008007_abnormal_cellular_replicative1.07154411
112MP0003566_abnormal_cell_adhesion1.06688187
113MP0005503_abnormal_tendon_morphology1.06252659
114MP0005253_abnormal_eye_physiology1.06146078
115MP0003453_abnormal_keratinocyte_physiol1.06102185
116MP0003786_premature_aging1.04519771
117MP0002896_abnormal_bone_mineralization1.04185535
118MP0002092_abnormal_eye_morphology1.04033635
119MP0005620_abnormal_muscle_contractility1.03170608
120MP0002111_abnormal_tail_morphology1.02605900
121MP0005395_other_phenotype1.01185420
122MP0004036_abnormal_muscle_relaxation1.00655865
123MP0002697_abnormal_eye_size1.00383635
124MP0001188_hyperpigmentation1.00206682
125MP0004272_abnormal_basement_membrane1.00076853
126MP0001348_abnormal_lacrimal_gland0.98605504
127MP0005391_vision/eye_phenotype0.98368712
128MP0004185_abnormal_adipocyte_glucose0.98308306
129MP0009703_decreased_birth_body0.97379579
130MP0002090_abnormal_vision0.97212043
131MP0002109_abnormal_limb_morphology0.96356062
132MP0001986_abnormal_taste_sensitivity0.96274841
133MP0002653_abnormal_ependyma_morphology0.96204005
134MP0000653_abnormal_sex_gland0.95100807
135MP0002114_abnormal_axial_skeleton0.94790560
136MP0002210_abnormal_sex_determination0.94484400
137MP0008872_abnormal_physiological_respon0.93573204
138MP0003861_abnormal_nervous_system0.93548704
139MP0009697_abnormal_copulation0.93324302
140MP0001486_abnormal_startle_reflex0.93039011
141MP0000647_abnormal_sebaceous_gland0.92048175
142MP0001929_abnormal_gametogenesis0.91673955
143MP0002734_abnormal_mechanical_nocicepti0.91338952
144MP0003137_abnormal_impulse_conducting0.91294681
145MP0009780_abnormal_chondrocyte_physiolo0.90717352
146MP0003938_abnormal_ear_development0.88090794
147MP0004264_abnormal_extraembryonic_tissu0.87822351
148MP0002752_abnormal_somatic_nervous0.87787759
149MP0000613_abnormal_salivary_gland0.87073245
150MP0002085_abnormal_embryonic_tissue0.86750212
151MP0001145_abnormal_male_reproductive0.84926151
152MP0001216_abnormal_epidermal_layer0.84138502
153MP0003123_paternal_imprinting0.83057881
154MP0004215_abnormal_myocardial_fiber0.82090138
155MP0009672_abnormal_birth_weight0.81623526
156MP0002115_abnormal_skeleton_extremities0.80885573
157MP0004134_abnormal_chest_morphology0.80170915
158MP0001119_abnormal_female_reproductive0.79345079
159MP0006276_abnormal_autonomic_nervous0.78720917
160MP0002084_abnormal_developmental_patter0.73708144
161MP0005195_abnormal_posterior_eye0.72481284
162MP0003698_abnormal_male_reproductive0.69806325

Predicted human phenotypes

RankGene SetZ-score
1Distal arthrogryposis (HP:0005684)5.35597032
2Muscle fiber inclusion bodies (HP:0100299)5.08711842
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.05557924
4Nemaline bodies (HP:0003798)4.58002111
5Type 1 muscle fiber predominance (HP:0003803)4.44237547
6Exercise-induced myalgia (HP:0003738)4.41047914
7Exercise-induced muscle cramps (HP:0003710)4.35374448
8Absent phalangeal crease (HP:0006109)4.31405996
9Fragile nails (HP:0001808)4.16633200
10Round ear (HP:0100830)4.10028216
11Ulnar deviation of the wrist (HP:0003049)4.04943042
12Intestinal atresia (HP:0011100)3.94372517
13Calcaneovalgus deformity (HP:0001848)3.82273870
14Abnormality of the labia minora (HP:0012880)3.62878863
15Deformed tarsal bones (HP:0008119)3.56707378
16Abnormal finger flexion creases (HP:0006143)3.56181373
17Myopathic facies (HP:0002058)3.46456232
18Down-sloping shoulders (HP:0200021)3.38482052
19Volvulus (HP:0002580)3.26150121
20Scapular winging (HP:0003691)3.25325288
21Mixed hearing impairment (HP:0000410)3.24605148
22Muscle hypertrophy of the lower extremities (HP:0008968)3.24346372
23Aplasia/Hypoplasia of the uvula (HP:0010293)3.23747459
24Ependymoma (HP:0002888)3.21776158
25Difficulty running (HP:0009046)3.20049324
26Oligodactyly (hands) (HP:0001180)3.19781475
27Fatigable weakness (HP:0003473)3.18447905
28Abnormality of the neuromuscular junction (HP:0003398)3.18447905
29Lip pit (HP:0100267)3.18130497
30Milia (HP:0001056)3.13341141
31Meckel diverticulum (HP:0002245)3.09702318
32Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09435708
33Ectopic kidney (HP:0000086)3.08553531
34Abnormality of the ileum (HP:0001549)3.04233542
35Calf muscle hypertrophy (HP:0008981)3.02971163
36Muscle fiber splitting (HP:0003555)2.99795580
37Chorioretinal atrophy (HP:0000533)2.99357707
38Aqueductal stenosis (HP:0002410)2.96596001
39Chromsome breakage (HP:0040012)2.82025200
40Increased connective tissue (HP:0009025)2.81801442
41Abnormality of chromosome stability (HP:0003220)2.81475282
42Onycholysis (HP:0001806)2.80756603
43Malignant hyperthermia (HP:0002047)2.77463707
44Abnormality of the calf musculature (HP:0001430)2.75545946
45Abnormal lung lobation (HP:0002101)2.73746715
46Atrophic scars (HP:0001075)2.73591963
47Morphological abnormality of the middle ear (HP:0008609)2.71750019
48Posterior subcapsular cataract (HP:0007787)2.69468067
49Absent radius (HP:0003974)2.69065334
50Right ventricular cardiomyopathy (HP:0011663)2.65409536
51Abnormality of the calcaneus (HP:0008364)2.65062994
52Pterygium (HP:0001059)2.64184939
53Pancreatic cysts (HP:0001737)2.60217425
54Hyporeflexia of lower limbs (HP:0002600)2.58672923
55Pili torti (HP:0003777)2.57797825
56True hermaphroditism (HP:0010459)2.56331319
57Abnormality of the duodenum (HP:0002246)2.53737761
58Aplasia involving forearm bones (HP:0009822)2.53236203
59Absent forearm bone (HP:0003953)2.53236203
60Weak cry (HP:0001612)2.52113034
61Periauricular skin pits (HP:0100277)2.51519427
62Preauricular pit (HP:0004467)2.51519427
63Gastrointestinal atresia (HP:0002589)2.50674275
64Plantar hyperkeratosis (HP:0007556)2.50502640
65Horseshoe kidney (HP:0000085)2.49674889
66Abnormality of the ischium (HP:0003174)2.47522519
67EMG: myopathic abnormalities (HP:0003458)2.46994159
68Hypoplastic ischia (HP:0003175)2.45146276
69Type 2 muscle fiber atrophy (HP:0003554)2.44957372
70Bifid tongue (HP:0010297)2.43164830
71Vitreoretinal degeneration (HP:0000655)2.42049374
72Abnormality of the lacrimal duct (HP:0011481)2.41878224
73Abnormality of the preputium (HP:0100587)2.39096068
74Renal hypoplasia (HP:0000089)2.36990391
75Triphalangeal thumb (HP:0001199)2.36268338
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.36127181
77Popliteal pterygium (HP:0009756)2.35177603
78Progressive inability to walk (HP:0002505)2.34768675
79Small intestinal stenosis (HP:0012848)2.33663674
80Duodenal stenosis (HP:0100867)2.33663674
81Abnormality of the parathyroid morphology (HP:0011766)2.33049340
82Pancreatic fibrosis (HP:0100732)2.33032930
83Colon cancer (HP:0003003)2.32815482
84Muscle fiber atrophy (HP:0100295)2.32368074
85Severe Myopia (HP:0011003)2.32039566
86Tarsal synostosis (HP:0008368)2.31522736
87Pelvic girdle muscle weakness (HP:0003749)2.31430982
88Oligodactyly (HP:0012165)2.31416564
89Shoulder girdle muscle weakness (HP:0003547)2.30810876
90Septo-optic dysplasia (HP:0100842)2.30492287
91Anophthalmia (HP:0000528)2.30222069
92Astrocytoma (HP:0009592)2.30140920
93Abnormality of the astrocytes (HP:0100707)2.30140920
94Mildly elevated creatine phosphokinase (HP:0008180)2.29769932
95Stenosis of the external auditory canal (HP:0000402)2.27928784
96Abnormality of the shoulder girdle musculature (HP:0001435)2.27654139
97Glioma (HP:0009733)2.26860571
98Molar tooth sign on MRI (HP:0002419)2.26472655
99Abnormality of midbrain morphology (HP:0002418)2.26472655
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.25992752
101Esophageal atresia (HP:0002032)2.25630070
102Aplasia/Hypoplasia involving the musculature (HP:0001460)2.25305142
103Congenital malformation of the right heart (HP:0011723)2.24395288
104Double outlet right ventricle (HP:0001719)2.24395288
105Dandy-Walker malformation (HP:0001305)2.22311517
106Methylmalonic acidemia (HP:0002912)2.21321494
107Alacrima (HP:0000522)2.20903304
108Anencephaly (HP:0002323)2.19101087
109Small hand (HP:0200055)2.17174637
110Optic nerve hypoplasia (HP:0000609)2.16892093
111Difficulty climbing stairs (HP:0003551)2.15896784
112Carpal bone hypoplasia (HP:0001498)2.13939118
113Nasolacrimal duct obstruction (HP:0000579)2.13485626
114Abnormality of the nasolacrimal system (HP:0000614)2.12585493
115Synostosis involving bones of the feet (HP:0009140)2.12154996
116Synostosis involving bones of the lower limbs (HP:0009138)2.12154996
117Labial hypoplasia (HP:0000066)2.11691746
118Symphalangism affecting the phalanges of the hand (HP:0009773)2.10526704
119Woolly hair (HP:0002224)2.08986529
120Abnormality of the distal phalanges of the toes (HP:0010182)2.07586724
121Absent septum pellucidum (HP:0001331)2.07551289
122Gonadotropin excess (HP:0000837)2.06441294
123Preaxial hand polydactyly (HP:0001177)2.06433148
124Nephronophthisis (HP:0000090)2.06231617
125Abnormality of the hip-girdle musculature (HP:0001445)2.05939096
126Abnormality of the musculature of the pelvis (HP:0001469)2.05939096
127Hypoplastic female external genitalia (HP:0012815)2.04882790
128Aplasia/Hypoplasia of the tongue (HP:0010295)2.03908853
129Myoglobinuria (HP:0002913)2.03178294
130Ulnar deviation of finger (HP:0009465)2.01272790
131Hypotrichosis (HP:0001006)1.99669513
132Cupped ear (HP:0000378)1.98822908
133Advanced eruption of teeth (HP:0006288)1.98809704
134Myotonia (HP:0002486)1.98669152
135Hip contracture (HP:0003273)1.98027969
136Skin pits (HP:0100276)1.97850513
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97515925
138Rhabdomyosarcoma (HP:0002859)1.95055138
139Nephroblastoma (Wilms tumor) (HP:0002667)1.94957032
140Fragile skin (HP:0001030)1.94277923
141Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93659162
142Hemivertebrae (HP:0002937)1.91750686
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.91555088
144Absent thumb (HP:0009777)1.89754343
145Clubbing of toes (HP:0100760)1.88178634
146Embryonal renal neoplasm (HP:0011794)1.87675903
147Natal tooth (HP:0000695)1.87236264
148Fetal akinesia sequence (HP:0001989)1.86198545
149Abnormality of the septum pellucidum (HP:0007375)1.85418275
150Abnormality of abdominal situs (HP:0011620)1.84912314
151Abdominal situs inversus (HP:0003363)1.84912314
152Cutaneous finger syndactyly (HP:0010554)1.84908639
153Hypoplastic pelvis (HP:0008839)1.83784077
154Absent eyebrow (HP:0002223)1.83577539
155Sloping forehead (HP:0000340)1.83151393
156Renal agenesis (HP:0000104)1.82487295
157Subcapsular cataract (HP:0000523)1.82173226
158Muscle stiffness (HP:0003552)1.82056986
159Supernumerary spleens (HP:0009799)1.81759133
160Hypoplastic labia majora (HP:0000059)1.81513563
161Agnosia (HP:0010524)1.81455799
162Abnormality of the labia majora (HP:0012881)1.80673782
163Abnormality of the pubic bones (HP:0003172)1.79698003
164Neck muscle weakness (HP:0000467)1.79600116
165Selective tooth agenesis (HP:0001592)1.79152284
166Frequent falls (HP:0002359)1.78890324
167Genital tract atresia (HP:0001827)1.78713415
168Central scotoma (HP:0000603)1.78454713
169Sclerocornea (HP:0000647)1.78067024
170Short palpebral fissure (HP:0012745)1.77303312
171Medial flaring of the eyebrow (HP:0010747)1.76459186
172Rimmed vacuoles (HP:0003805)1.76424349
173Metatarsus adductus (HP:0001840)1.75729581
174Distal lower limb muscle weakness (HP:0009053)1.73379601
175Pancreatic islet-cell hyperplasia (HP:0004510)1.73125166
176Amniotic constriction ring (HP:0009775)1.72996040
177Abnormality of placental membranes (HP:0011409)1.72996040
178Hyperglycinemia (HP:0002154)1.72961732
179Shallow orbits (HP:0000586)1.71831976
180Subaortic stenosis (HP:0001682)1.71606890
181Chin dimple (HP:0010751)1.71309213
182Inability to walk (HP:0002540)1.71210823
183Vaginal atresia (HP:0000148)1.70998094
184Short 1st metacarpal (HP:0010034)1.70617354
185Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70617354
186Abnormality of the labia (HP:0000058)1.68707110
187Chorioretinal coloboma (HP:0000567)1.68213477
188Neoplasm of the adrenal cortex (HP:0100641)1.66643119
189Patellar aplasia (HP:0006443)1.66019356
190Abnormality of the renal medulla (HP:0100957)1.65463226
191Aplasia/Hypoplasia of the fovea (HP:0008060)1.63366752

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB25.57654577
2LATS13.97181504
3OBSCN3.88863655
4TRIM283.55966355
5TTN3.49353321
6TNIK3.44415198
7WNK33.38484394
8BUB12.91534287
9EPHA42.86462765
10DDR22.67686481
11PHKG22.61249883
12PHKG12.61249883
13MUSK2.59273005
14MAP3K102.41048705
15PIK3CG2.24453140
16ERBB32.14067170
17NME12.10259792
18TRIB32.09827964
19PTK61.98271256
20PLK21.90678687
21ERBB41.89932679
22VRK21.85452483
23SIK11.79724225
24BRSK21.76365317
25FGFR21.70649688
26MAP4K21.70439716
27FER1.66652445
28PLK41.66636665
29TTK1.64723056
30EEF2K1.62207622
31SRPK11.55678654
32EIF2AK31.55501759
33MAPK131.47929691
34MAPK151.47217214
35CDC71.46695924
36MST41.45382924
37CASK1.44972707
38CCNB11.44044056
39PIK3CA1.40360117
40ZAK1.39901455
41BCR1.39808419
42PBK1.38572086
43RPS6KB21.36727036
44VRK11.35923653
45PDGFRA1.35179766
46ERBB21.33116738
47WEE11.30357192
48FGFR11.29151265
49GRK11.28085080
50PLK11.25438953
51DYRK1B1.22869657
52MAP3K31.19913334
53TGFBR11.16156389
54TAF11.15350782
55STK161.13333941
56NUAK11.10200120
57CDK61.08453576
58HIPK21.05162976
59STK31.04734996
60PKN21.03744192
61LATS21.03724345
62PASK1.02790360
63TYRO31.02093865
64FLT31.02062512
65NEK11.01622336
66FGFR41.00294137
67TRPM70.98836723
68OXSR10.95654183
69INSRR0.94420254
70MAP2K30.94136916
71CSNK1A1L0.92955342
72CDK120.92752012
73EPHA30.90228070
74SIK30.85402753
75STK38L0.84827690
76CDC42BPA0.83006552
77BCKDK0.82325010
78MARK10.82253550
79STK390.82058625
80DYRK20.81313545
81PTK20.81208833
82BMPR1B0.80440769
83MKNK10.80334322
84DYRK30.79868815
85MAP3K20.78623390
86DMPK0.78502348
87MINK10.77926288
88PDK20.77505529
89FGFR30.74171880
90ATR0.74103912
91MAP2K60.71965728
92AKT20.71853954
93BRSK10.71325022
94NLK0.70856112
95KSR10.68259857
96ADRBK20.66862331
97MAP2K10.65134016
98PAK40.63793995
99GSK3A0.63232849
100CAMK2G0.63002116
101MARK30.62970316
102CHEK20.62877377
103PAK20.61200673
104MAP3K40.60875440
105MAP3K70.60678193
106EPHB10.60662734
107PRKCG0.59152367
108RIPK10.58992214
109LMTK20.58699914
110FRK0.58339423
111DAPK20.58255855
112CDK90.57422325
113PRKD30.57385457
114EIF2AK10.57161626
115ILK0.56967689
116ACVR1B0.55963472
117LRRK20.55283728
118LIMK10.54464154
119ATM0.53898703
120TIE10.53382461
121PRKCE0.51560182
122PNCK0.51271886
123MTOR0.50972459
124EIF2AK20.50957426
125MOS0.50567514
126AURKB0.50496003
127PRKCI0.49776117
128ROCK10.49259924
129CSNK1G20.47907576
130CDK30.47843974
131CDK190.47539676
132TGFBR20.46343850
133MKNK20.45727492
134ICK0.45024009
135BRD40.42088275
136CHEK10.40022016
137CSNK1G30.39311460
138PDGFRB0.39133086
139CLK10.37972410
140NTRK20.37122463
141RPS6KA20.37094836
142RPS6KA10.36539117
143CSNK1D0.36171584
144PKN10.35385767
145KSR20.34546223
146CSNK1G10.33926446
147PINK10.33844216
148PAK30.33691625
149STK110.33600149
150MELK0.33204659
151MST1R0.33065221
152WNK40.33035484
153PRKAA10.33005907
154PRKDC0.32759433
155NEK20.32667693
156DYRK1A0.32660482
157CSNK2A10.32165682
158RET0.29709950
159STK40.28709069
160PLK30.28105907
161CDK10.28093023
162MAPKAPK30.27508215
163PRKD10.27427885
164CSNK1A10.26642116
165MET0.26487876
166TSSK60.26317666
167MAPK90.25905626
168CDK11A0.25596068
169YES10.23256519

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.20622975
2Basal cell carcinoma_Homo sapiens_hsa052173.64003911
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.28666128
4Fanconi anemia pathway_Homo sapiens_hsa034603.13369844
5Hippo signaling pathway_Homo sapiens_hsa043903.00295450
6Propanoate metabolism_Homo sapiens_hsa006402.79279956
7Proteasome_Homo sapiens_hsa030502.71953770
8Homologous recombination_Homo sapiens_hsa034402.70903266
9Mismatch repair_Homo sapiens_hsa034302.68968762
10Phototransduction_Homo sapiens_hsa047442.61752437
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.53406924
12Tight junction_Homo sapiens_hsa045302.50327014
13Hedgehog signaling pathway_Homo sapiens_hsa043402.43913273
14Basal transcription factors_Homo sapiens_hsa030222.37018933
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.27938948
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20065219
17Adherens junction_Homo sapiens_hsa045202.19658434
18Dilated cardiomyopathy_Homo sapiens_hsa054142.18235709
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.15983053
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15790647
21Steroid biosynthesis_Homo sapiens_hsa001002.06941263
22ECM-receptor interaction_Homo sapiens_hsa045122.01174737
23Wnt signaling pathway_Homo sapiens_hsa043102.00600009
24Proteoglycans in cancer_Homo sapiens_hsa052051.99043705
25DNA replication_Homo sapiens_hsa030301.98542089
26Protein export_Homo sapiens_hsa030601.96544480
27RNA degradation_Homo sapiens_hsa030181.96296373
28RNA polymerase_Homo sapiens_hsa030201.90158521
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88913587
30RNA transport_Homo sapiens_hsa030131.88762529
31Circadian rhythm_Homo sapiens_hsa047101.85025306
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.80792656
33TGF-beta signaling pathway_Homo sapiens_hsa043501.80781663
34Melanogenesis_Homo sapiens_hsa049161.79557339
35Notch signaling pathway_Homo sapiens_hsa043301.77113168
36Focal adhesion_Homo sapiens_hsa045101.73642459
37Axon guidance_Homo sapiens_hsa043601.73579430
38Cell cycle_Homo sapiens_hsa041101.67626691
39Bladder cancer_Homo sapiens_hsa052191.65609854
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65386740
41Base excision repair_Homo sapiens_hsa034101.56142542
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56103164
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52908927
44Protein digestion and absorption_Homo sapiens_hsa049741.51874664
45Fatty acid elongation_Homo sapiens_hsa000621.46131005
46Insulin resistance_Homo sapiens_hsa049311.45538212
47Nucleotide excision repair_Homo sapiens_hsa034201.45495531
48Insulin signaling pathway_Homo sapiens_hsa049101.44038843
49Endometrial cancer_Homo sapiens_hsa052131.44028202
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41031524
51Glucagon signaling pathway_Homo sapiens_hsa049221.39182226
52One carbon pool by folate_Homo sapiens_hsa006701.37823525
53Selenocompound metabolism_Homo sapiens_hsa004501.34357050
54Cardiac muscle contraction_Homo sapiens_hsa042601.32537915
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.32155743
56Pyruvate metabolism_Homo sapiens_hsa006201.31442686
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30111097
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30004679
59Thyroid cancer_Homo sapiens_hsa052161.25217567
60Oxytocin signaling pathway_Homo sapiens_hsa049211.24906336
61Central carbon metabolism in cancer_Homo sapiens_hsa052301.23829545
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23084213
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21991810
64Vitamin B6 metabolism_Homo sapiens_hsa007501.17138127
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16303298
66Spliceosome_Homo sapiens_hsa030401.13965163
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11430890
68Chronic myeloid leukemia_Homo sapiens_hsa052201.08892290
69p53 signaling pathway_Homo sapiens_hsa041151.08157768
70Starch and sucrose metabolism_Homo sapiens_hsa005001.07991808
71Nitrogen metabolism_Homo sapiens_hsa009101.06803978
72Butanoate metabolism_Homo sapiens_hsa006501.06682897
73cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06197851
74Glioma_Homo sapiens_hsa052141.05616320
75Small cell lung cancer_Homo sapiens_hsa052221.04759447
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04232210
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04127832
78Leukocyte transendothelial migration_Homo sapiens_hsa046701.02309963
79Pathways in cancer_Homo sapiens_hsa052000.99343949
80Tryptophan metabolism_Homo sapiens_hsa003800.99274300
81MicroRNAs in cancer_Homo sapiens_hsa052060.98781382
82Nicotine addiction_Homo sapiens_hsa050330.98622902
83GnRH signaling pathway_Homo sapiens_hsa049120.97077894
84Colorectal cancer_Homo sapiens_hsa052100.96985903
85Ether lipid metabolism_Homo sapiens_hsa005650.95873893
86Prostate cancer_Homo sapiens_hsa052150.95373354
87Melanoma_Homo sapiens_hsa052180.95240697
88Lysine degradation_Homo sapiens_hsa003100.95166558
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94610423
90Caffeine metabolism_Homo sapiens_hsa002320.93951192
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93677912
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92950369
93Gastric acid secretion_Homo sapiens_hsa049710.92553614
94Amoebiasis_Homo sapiens_hsa051460.90966173
95Purine metabolism_Homo sapiens_hsa002300.90891996
96mTOR signaling pathway_Homo sapiens_hsa041500.90643284
97Pyrimidine metabolism_Homo sapiens_hsa002400.87812968
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86127231
99HTLV-I infection_Homo sapiens_hsa051660.85572698
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83904298
101Estrogen signaling pathway_Homo sapiens_hsa049150.81484324
102Parkinsons disease_Homo sapiens_hsa050120.81359772
103Retinol metabolism_Homo sapiens_hsa008300.80376582
104AMPK signaling pathway_Homo sapiens_hsa041520.79169938
105mRNA surveillance pathway_Homo sapiens_hsa030150.78365698
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77681313
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76963745
108Linoleic acid metabolism_Homo sapiens_hsa005910.76022405
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75250117
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.73840214
111FoxO signaling pathway_Homo sapiens_hsa040680.73738606
112Oxidative phosphorylation_Homo sapiens_hsa001900.71935403
113Renal cell carcinoma_Homo sapiens_hsa052110.71605880
114Fatty acid degradation_Homo sapiens_hsa000710.70709005
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70199164
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69365034
117ErbB signaling pathway_Homo sapiens_hsa040120.67931186
118VEGF signaling pathway_Homo sapiens_hsa043700.67492011
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67247954
120Fatty acid metabolism_Homo sapiens_hsa012120.66617974
121Renin secretion_Homo sapiens_hsa049240.65653999
122Non-small cell lung cancer_Homo sapiens_hsa052230.64004453
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63772665
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63454457
125Huntingtons disease_Homo sapiens_hsa050160.62774294
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62501294
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61614492
128Cholinergic synapse_Homo sapiens_hsa047250.61198892
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60375787
130Rap1 signaling pathway_Homo sapiens_hsa040150.59866844
131Galactose metabolism_Homo sapiens_hsa000520.59839660
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59080161
133HIF-1 signaling pathway_Homo sapiens_hsa040660.58863977
134Insulin secretion_Homo sapiens_hsa049110.57800193
135MAPK signaling pathway_Homo sapiens_hsa040100.57208595
136Peroxisome_Homo sapiens_hsa041460.57032192
137Prolactin signaling pathway_Homo sapiens_hsa049170.55380013
138Metabolic pathways_Homo sapiens_hsa011000.54829513
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54544861
140Chemical carcinogenesis_Homo sapiens_hsa052040.54165794
141Viral myocarditis_Homo sapiens_hsa054160.53611311
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.52183369
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51613617
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50377833
145beta-Alanine metabolism_Homo sapiens_hsa004100.50370759
146Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50322531
147Fat digestion and absorption_Homo sapiens_hsa049750.49353094
148Glutathione metabolism_Homo sapiens_hsa004800.48837970
149Type II diabetes mellitus_Homo sapiens_hsa049300.48488500
150Olfactory transduction_Homo sapiens_hsa047400.48404123
151Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47395897
152Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46876390
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45158940
154Taste transduction_Homo sapiens_hsa047420.44677905
155Mineral absorption_Homo sapiens_hsa049780.43805639
156Carbon metabolism_Homo sapiens_hsa012000.43645948
157Calcium signaling pathway_Homo sapiens_hsa040200.43052636
158Primary bile acid biosynthesis_Homo sapiens_hsa001200.42488252
159Sulfur metabolism_Homo sapiens_hsa009200.42235425
160Biosynthesis of amino acids_Homo sapiens_hsa012300.41616067
161Phenylalanine metabolism_Homo sapiens_hsa003600.41589558
162Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41582973
163Toxoplasmosis_Homo sapiens_hsa051450.41416837
164Amphetamine addiction_Homo sapiens_hsa050310.41267378
165cAMP signaling pathway_Homo sapiens_hsa040240.38715127
166Oocyte meiosis_Homo sapiens_hsa041140.38303508
167Folate biosynthesis_Homo sapiens_hsa007900.37177719
168Pancreatic cancer_Homo sapiens_hsa052120.37039041
169Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35426302
170Gap junction_Homo sapiens_hsa045400.35173291
171Alcoholism_Homo sapiens_hsa050340.34109195
172Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33587592
173Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33403630
174Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32454758
175Steroid hormone biosynthesis_Homo sapiens_hsa001400.30080878
176Alzheimers disease_Homo sapiens_hsa050100.29594403
177Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29311335
178Arginine and proline metabolism_Homo sapiens_hsa003300.27738850
179Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27053872

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