SHISA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.99781256
2axon ensheathment in central nervous system (GO:0032291)8.99781256
3actin-myosin filament sliding (GO:0033275)8.94688941
4muscle filament sliding (GO:0030049)8.94688941
5sarcoplasmic reticulum calcium ion transport (GO:0070296)8.29624178
6actin-mediated cell contraction (GO:0070252)7.29990416
7skeletal muscle contraction (GO:0003009)6.95620100
8regulation of skeletal muscle contraction (GO:0014819)6.77682189
9fatty acid elongation (GO:0030497)6.18344044
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.00246717
11regulation of relaxation of muscle (GO:1901077)5.75324215
12striated muscle contraction (GO:0006941)5.74785031
13ensheathment of neurons (GO:0007272)5.74030133
14axon ensheathment (GO:0008366)5.74030133
15myelination (GO:0042552)5.73752286
16actin filament-based movement (GO:0030048)5.47148980
17myofibril assembly (GO:0030239)5.32286499
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.30389744
19skeletal muscle fiber development (GO:0048741)5.09799659
20response to muscle activity (GO:0014850)4.98424624
21response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.96390646
22sarcomere organization (GO:0045214)4.93817022
23long-chain fatty acid biosynthetic process (GO:0042759)4.85689815
24cardiac muscle contraction (GO:0060048)4.78322655
25regulation of cell communication by electrical coupling (GO:0010649)4.73617969
26regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.71721732
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.58338070
28muscle contraction (GO:0006936)4.46942694
29plasma membrane repair (GO:0001778)4.44045803
30myotube cell development (GO:0014904)4.43084489
31regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.42825952
32cardiac myofibril assembly (GO:0055003)4.35306264
33regulation of actin filament-based movement (GO:1903115)4.32634618
34response to inactivity (GO:0014854)4.30179234
35cholesterol biosynthetic process (GO:0006695)4.21252463
36myelin maintenance (GO:0043217)4.19733518
37negative regulation of neurotransmitter transport (GO:0051589)4.10312439
38oligodendrocyte differentiation (GO:0048709)4.08823857
39synaptic vesicle docking involved in exocytosis (GO:0016081)4.07872726
40negative regulation of neurotransmitter secretion (GO:0046929)4.05734367
41creatine metabolic process (GO:0006600)4.04387635
42L-amino acid import (GO:0043092)4.03501799
43glycogen catabolic process (GO:0005980)4.01095631
44muscle system process (GO:0003012)3.98584709
45negative regulation of protein localization to cell surface (GO:2000009)3.95044118
46NADH metabolic process (GO:0006734)3.89925266
47actomyosin structure organization (GO:0031032)3.84383431
48eye photoreceptor cell differentiation (GO:0001754)3.83512729
49photoreceptor cell differentiation (GO:0046530)3.83512729
50presynaptic membrane organization (GO:0097090)3.77162444
51neuronal action potential propagation (GO:0019227)3.76941777
52establishment of mitochondrion localization (GO:0051654)3.76697869
53substantia nigra development (GO:0021762)3.74309602
54glucan catabolic process (GO:0009251)3.72697305
55cardiac muscle hypertrophy (GO:0003300)3.71973247
56presynaptic membrane assembly (GO:0097105)3.70430409
57regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.68270501
58sterol biosynthetic process (GO:0016126)3.67518201
59skeletal muscle adaptation (GO:0043501)3.64214475
60regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.60043068
61muscle fiber development (GO:0048747)3.59896133
62neuron cell-cell adhesion (GO:0007158)3.59643372
63cellular potassium ion homeostasis (GO:0030007)3.59090452
64regulation of calcium ion transmembrane transporter activity (GO:1901019)3.56669116
65regulation of calcium ion transmembrane transport (GO:1903169)3.56669116
66apical protein localization (GO:0045176)3.55222068
67striated muscle hypertrophy (GO:0014897)3.54386502
68neuromuscular synaptic transmission (GO:0007274)3.54014434
69astrocyte development (GO:0014002)3.53548041
70glycerophospholipid catabolic process (GO:0046475)3.51655885
71glucan biosynthetic process (GO:0009250)3.49988350
72glycogen biosynthetic process (GO:0005978)3.49988350
73skeletal muscle tissue development (GO:0007519)3.47172167
74positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.45726953
75asymmetric protein localization (GO:0008105)3.45491372
76peripheral nervous system axon ensheathment (GO:0032292)3.45107375
77myelination in peripheral nervous system (GO:0022011)3.45107375
78muscle cell cellular homeostasis (GO:0046716)3.44551495
79cellular polysaccharide catabolic process (GO:0044247)3.43754016
80regulation of collateral sprouting (GO:0048670)3.41459725
81negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.40093056
82negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.38879807
83sodium ion export (GO:0071436)3.38055982
84positive regulation of synapse maturation (GO:0090129)3.36718737
85peptidyl-tyrosine autophosphorylation (GO:0038083)3.36511411
86transmission of nerve impulse (GO:0019226)3.36172308
87striated muscle adaptation (GO:0014888)3.35366119
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35304160
89negative regulation of calcium ion transmembrane transport (GO:1903170)3.35253735
90negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.35253735
91amino acid import (GO:0043090)3.31736565
92response to methylmercury (GO:0051597)3.26091455
93response to redox state (GO:0051775)3.26036621
94regulation of striated muscle contraction (GO:0006942)3.24693964
95long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.23498157
96synaptic vesicle maturation (GO:0016188)3.23087537
97positive regulation of myotube differentiation (GO:0010831)3.23008157
98gluconeogenesis (GO:0006094)3.22104175
99negative regulation of axonogenesis (GO:0050771)3.19074011
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.17928778
101isoprenoid biosynthetic process (GO:0008299)3.16793864
102adult walking behavior (GO:0007628)3.13956926
103regulation of the force of heart contraction (GO:0002026)3.11146564
104cardiac muscle hypertrophy in response to stress (GO:0014898)3.07780181
105muscle hypertrophy in response to stress (GO:0003299)3.07780181
106cardiac muscle adaptation (GO:0014887)3.07780181
107relaxation of muscle (GO:0090075)3.07344570
108muscle hypertrophy (GO:0014896)3.07177688
109regulation of membrane repolarization (GO:0060306)3.06586909
110polysaccharide catabolic process (GO:0000272)3.05429368
111cerebral cortex radially oriented cell migration (GO:0021799)3.04505622
1122-oxoglutarate metabolic process (GO:0006103)3.00500661
113negative regulation of potassium ion transmembrane transport (GO:1901380)2.99210426
114long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.98389181
115muscle organ development (GO:0007517)2.97446750
116import into cell (GO:0098657)2.95731763
117muscle structure development (GO:0061061)2.94909156
118cerebellar granule cell differentiation (GO:0021707)2.93778612
119fructose metabolic process (GO:0006000)2.93373736
120postsynaptic membrane organization (GO:0001941)2.93352477
121cell communication by electrical coupling (GO:0010644)2.92734674
122positive regulation of oligodendrocyte differentiation (GO:0048714)2.92164973
123regulation of skeletal muscle cell differentiation (GO:2001014)2.92063739
124potassium ion import (GO:0010107)2.91780707
125synaptic vesicle exocytosis (GO:0016079)2.91494308
126neuronal ion channel clustering (GO:0045161)2.90889019
127membrane tubulation (GO:0097320)2.89684329
128glutamate secretion (GO:0014047)2.88504874
129myoblast fusion (GO:0007520)2.87994740
130hexose biosynthetic process (GO:0019319)2.86200877
131virion attachment to host cell (GO:0019062)2.85424165
132adhesion of symbiont to host cell (GO:0044650)2.85424165
133negative regulation of axon extension (GO:0030517)2.85205708
134glycogen metabolic process (GO:0005977)2.84301410
135dendritic spine morphogenesis (GO:0060997)2.84010023
136negative regulation of muscle contraction (GO:0045932)2.83542290
137neuron recognition (GO:0008038)2.82694290
138positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.82439557
139negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.81895960
140regulation of synaptic vesicle transport (GO:1902803)2.79075886
141muscle tissue morphogenesis (GO:0060415)2.79067644
142tricarboxylic acid cycle (GO:0006099)2.77786610
143skeletal muscle tissue regeneration (GO:0043403)2.77744655
144regulation of sodium ion transmembrane transport (GO:1902305)2.77622140
145regulation of synapse maturation (GO:0090128)2.77317898
146glucan metabolic process (GO:0044042)2.77255178
147cellular glucan metabolic process (GO:0006073)2.77255178
148fatty-acyl-CoA biosynthetic process (GO:0046949)2.75136694
149neurotransmitter uptake (GO:0001504)2.74877271
150protein palmitoylation (GO:0018345)2.72317845
151locomotory exploration behavior (GO:0035641)2.70089346
152limb bud formation (GO:0060174)2.69491424
153axon development (GO:0061564)2.68512918
154detection of temperature stimulus involved in sensory perception (GO:0050961)2.67968109
155detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.67968109
156response to lipoprotein particle (GO:0055094)2.66057770
157amyloid precursor protein metabolic process (GO:0042982)2.65220120
158cellular response to epinephrine stimulus (GO:0071872)2.63583716
159magnesium ion transport (GO:0015693)2.62938343
160axonal fasciculation (GO:0007413)2.62083456
161regulation of synaptic vesicle exocytosis (GO:2000300)2.59221755
162neural nucleus development (GO:0048857)2.57354235
163dendrite morphogenesis (GO:0048813)2.57070719
164neuron remodeling (GO:0016322)2.53439008
165positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.53253932
166nerve growth factor signaling pathway (GO:0038180)2.52990182
167peripheral nervous system development (GO:0007422)2.50937982
168regulation of voltage-gated calcium channel activity (GO:1901385)2.50811879
169fatty-acyl-CoA metabolic process (GO:0035337)2.50655734
170positive regulation of action potential (GO:0045760)2.49868822
171cellular response to monoamine stimulus (GO:0071868)2.46046690
172cellular response to catecholamine stimulus (GO:0071870)2.46046690
173response to epinephrine (GO:0071871)2.45876413
174regulation of short-term neuronal synaptic plasticity (GO:0048172)2.43285481
175regulation of amyloid precursor protein catabolic process (GO:1902991)2.43234186
176gamma-aminobutyric acid signaling pathway (GO:0007214)2.39938575
177glial cell differentiation (GO:0010001)2.39859576
178membrane assembly (GO:0071709)2.39325926
179negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38335992
180protein localization to synapse (GO:0035418)2.37218387
181positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.36867678
182peptidyl-cysteine modification (GO:0018198)2.36466543
183L-serine transport (GO:0015825)2.36125600
184glycosylceramide metabolic process (GO:0006677)2.35413369
185long-term synaptic potentiation (GO:0060291)2.34593691
186ionotropic glutamate receptor signaling pathway (GO:0035235)2.33470944
187adult locomotory behavior (GO:0008344)2.32191662
188very long-chain fatty acid metabolic process (GO:0000038)2.30908300
189positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.30567019
190acyl-CoA biosynthetic process (GO:0071616)2.30511738
191thioester biosynthetic process (GO:0035384)2.30511738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.44036659
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.40599735
3GBX2_23144817_ChIP-Seq_PC3_Human3.23145369
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83152332
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81948984
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77442600
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.56644938
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.51191794
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50933116
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50933116
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46918747
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38966567
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38463421
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.38352439
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37313564
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.34907720
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33452005
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29113797
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27688742
20SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.24482784
21AR_21572438_ChIP-Seq_LNCaP_Human2.18316426
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.16526988
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12084692
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.06280063
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01530172
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.97166400
27DROSHA_22980978_ChIP-Seq_HELA_Human1.95660707
28TBX20_22328084_ChIP-Seq_HEART_Mouse1.93780864
29TBX20_22080862_ChIP-Seq_HEART_Mouse1.93780864
30LXR_22292898_ChIP-Seq_THP-1_Human1.91178226
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82728687
32SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.82701825
33* CTCF_27219007_Chip-Seq_Bcells_Human1.77694498
34* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.77184349
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75527300
36TAF15_26573619_Chip-Seq_HEK293_Human1.74845070
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71044052
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70578091
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69793212
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67108576
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.66858720
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66324873
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.62930707
44REST_21632747_ChIP-Seq_MESCs_Mouse1.62560238
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62029870
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.60708084
47KDM2B_26808549_Chip-Seq_K562_Human1.56893838
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54959078
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52568265
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52214274
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52043583
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46657661
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45126087
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43916747
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.42506200
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.37364723
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.36504624
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33388168
59ER_23166858_ChIP-Seq_MCF-7_Human1.33262233
60* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33034701
61TET1_21490601_ChIP-Seq_MESCs_Mouse1.31966135
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.29738489
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29235484
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28532986
65* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27887920
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27406273
67KDM2B_26808549_Chip-Seq_DND41_Human1.27307435
68* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24479196
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24163962
70VDR_22108803_ChIP-Seq_LS180_Human1.24087069
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.22533447
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21990954
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21521660
74SMC3_22415368_ChIP-Seq_MEFs_Mouse1.20846698
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.19862430
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19453024
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19315430
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19304258
79P300_19829295_ChIP-Seq_ESCs_Human1.18598604
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18503384
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16829323
82* SMC4_20622854_ChIP-Seq_HELA_Human1.16531670
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16467061
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16339816
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15376804
86MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14205795
87RACK7_27058665_Chip-Seq_MCF-7_Human1.13930730
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.13175575
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12072433
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11698272
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.11307582
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10868919
93CLOCK_20551151_ChIP-Seq_293T_Human1.10359079
94TRIM28_21343339_ChIP-Seq_HEK293_Human1.09524994
95SMAD4_21799915_ChIP-Seq_A2780_Human1.09436527
96POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09290481
97* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09254270
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.08979549
99* TP53_23651856_ChIP-Seq_MEFs_Mouse1.08216339
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07926115
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06810410
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05721972
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05721972
104EP300_21415370_ChIP-Seq_HL-1_Mouse1.05495752
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.04975675
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03942626
107SA1_27219007_Chip-Seq_ERYTHROID_Human1.03708459
108SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03601311
109ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03206687
110STAT3_23295773_ChIP-Seq_U87_Human1.03200268
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03028088
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03001298
113P68_20966046_ChIP-Seq_HELA_Human1.02877245
114FUS_26573619_Chip-Seq_HEK293_Human1.02436747
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02259470
116STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02009502
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01800539
118* SA1_27219007_Chip-Seq_Bcells_Human1.01180424
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00249268
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99547016
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99368865
122MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99180744
123RNF2_27304074_Chip-Seq_NSC_Mouse0.97812091
124SOX2_21211035_ChIP-Seq_LN229_Gbm0.97684709
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97613291
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97236523
127RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96032952
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95701727
129MYC_27129775_Chip-Seq_CORNEA_Mouse0.95630536
130SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94999340
131CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94849018
132* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94751491
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93163163
134CREB1_26743006_Chip-Seq_LNCaP_Human0.92592503
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92042770
136GATA1_19941827_ChIP-Seq_MEL_Mouse0.91987612
137EOMES_21245162_ChIP-Seq_HESCs_Human0.91886004
138TCF4_23295773_ChIP-Seq_U87_Human0.91668874
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91516258
140WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91191661
141RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91109349
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.90738284
143NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90580498
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90434741
145* PRDM14_20953172_ChIP-Seq_ESCs_Human0.89957136
146ZNF263_19887448_ChIP-Seq_K562_Human0.89726726
147* OCT4_19829295_ChIP-Seq_ESCs_Human0.89559480
148EGR1_19032775_ChIP-ChIP_M12_Human0.89362734
149OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88824928
150EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88764316
151DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87083708
152ZNF274_21170338_ChIP-Seq_K562_Hela0.86139330
153IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85335524
154TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85171960
155ESR2_21235772_ChIP-Seq_MCF-7_Human0.85121268
156CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84325943
157* NANOG_18555785_Chip-Seq_ESCs_Mouse0.83561227
158AHR_22903824_ChIP-Seq_MCF-7_Human0.83334202
159AR_25329375_ChIP-Seq_VCAP_Human0.82190419
160RUNX2_22187159_ChIP-Seq_PCA_Human0.81427019
161TP53_16413492_ChIP-PET_HCT116_Human0.81394085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.23339441
2MP0000920_abnormal_myelination4.13590486
3MP0003880_abnormal_central_pattern4.03604060
4MP0004859_abnormal_synaptic_plasticity3.63388217
5MP0004270_analgesia3.60879217
6MP0002106_abnormal_muscle_physiology3.10571209
7MP0000759_abnormal_skeletal_muscle3.06317890
8MP0004087_abnormal_muscle_fiber2.92061395
9MP0003329_amyloid_beta_deposits2.90697806
10MP0005369_muscle_phenotype2.65741199
11MP0002332_abnormal_exercise_endurance2.60663614
12MP0004130_abnormal_muscle_cell2.60255516
13MP0003690_abnormal_glial_cell2.59411516
14MP0001486_abnormal_startle_reflex2.58203484
15MP0004233_abnormal_muscle_weight2.55164206
16MP0002269_muscular_atrophy2.53431907
17MP0002064_seizures2.53109485
18MP0002272_abnormal_nervous_system2.52922848
19MP0000750_abnormal_muscle_regeneration2.50862805
20MP0003635_abnormal_synaptic_transmissio2.50234043
21MP0005620_abnormal_muscle_contractility2.44675004
22MP0004084_abnormal_cardiac_muscle2.44300495
23MP0004885_abnormal_endolymph2.36300730
24MP0003950_abnormal_plasma_membrane2.34472204
25MP0000778_abnormal_nervous_system2.26778737
26MP0001905_abnormal_dopamine_level2.22137662
27MP0001529_abnormal_vocalization2.19637826
28MP0005423_abnormal_somatic_nervous2.19377803
29MP0009745_abnormal_behavioral_response2.19169069
30MP0005330_cardiomyopathy2.18790691
31MP0003634_abnormal_glial_cell2.17988066
32MP0002734_abnormal_mechanical_nocicepti2.17471360
33MP0009046_muscle_twitch2.17392436
34MP0005171_absent_coat_pigmentation2.10540928
35MP0004142_abnormal_muscle_tone2.08212456
36MP0004742_abnormal_vestibular_system2.04433220
37MP0002063_abnormal_learning/memory/cond1.93101053
38MP0002972_abnormal_cardiac_muscle1.89902143
39MP0000733_abnormal_muscle_development1.86258711
40MP0002572_abnormal_emotion/affect_behav1.81710059
41MP0001440_abnormal_grooming_behavior1.80845292
42MP0001485_abnormal_pinna_reflex1.75693579
43MP0003632_abnormal_nervous_system1.71221023
44MP0000955_abnormal_spinal_cord1.69107465
45MP0005551_abnormal_eye_electrophysiolog1.65668514
46MP0008569_lethality_at_weaning1.62772566
47MP0002837_dystrophic_cardiac_calcinosis1.62612768
48MP0002229_neurodegeneration1.62203740
49MP0004510_myositis1.56128700
50MP0004215_abnormal_myocardial_fiber1.55285873
51MP0002882_abnormal_neuron_morphology1.54623946
52MP0003136_yellow_coat_color1.52699143
53MP0001970_abnormal_pain_threshold1.52360803
54MP0001968_abnormal_touch/_nociception1.52103118
55MP0004858_abnormal_nervous_system1.51407125
56MP0002067_abnormal_sensory_capabilities1.51401405
57MP0003879_abnormal_hair_cell1.50893522
58MP0004145_abnormal_muscle_electrophysio1.50243260
59MP0000462_abnormal_digestive_system1.49938539
60MP0002733_abnormal_thermal_nociception1.44381747
61MP0006036_abnormal_mitochondrial_physio1.40746381
62MP0001299_abnormal_eye_distance/1.40562479
63MP0004484_altered_response_of1.39493828
64MP0000013_abnormal_adipose_tissue1.37943127
65MP0003631_nervous_system_phenotype1.37351303
66MP0002735_abnormal_chemical_nociception1.36718487
67MP0002066_abnormal_motor_capabilities/c1.35860633
68MP0000604_amyloidosis1.34502833
69MP0004134_abnormal_chest_morphology1.33357181
70MP0005623_abnormal_meninges_morphology1.33312954
71MP0000747_muscle_weakness1.29438027
72MP0005386_behavior/neurological_phenoty1.28683976
73MP0004924_abnormal_behavior1.28683976
74MP0002736_abnormal_nociception_after1.28597891
75MP0006138_congestive_heart_failure1.26503398
76MP0000751_myopathy1.24021427
77MP0002752_abnormal_somatic_nervous1.22751181
78MP0010630_abnormal_cardiac_muscle1.22414721
79MP0005409_darkened_coat_color1.22037723
80MP0005410_abnormal_fertilization1.20013126
81MP0003633_abnormal_nervous_system1.19555134
82MP0002090_abnormal_vision1.18257602
83MP0001963_abnormal_hearing_physiology1.16697758
84MP0002184_abnormal_innervation1.16400034
85MP0005646_abnormal_pituitary_gland1.11307487
86MP0005385_cardiovascular_system_phenoty1.10899605
87MP0001544_abnormal_cardiovascular_syste1.10899605
88MP0002557_abnormal_social/conspecific_i1.07636245
89MP0003705_abnormal_hypodermis_morpholog1.06162757
90MP0001501_abnormal_sleep_pattern1.02854188
91MP0002152_abnormal_brain_morphology1.02754353
92MP0000749_muscle_degeneration1.02297524
93MP0009780_abnormal_chondrocyte_physiolo0.99893463
94MP0001502_abnormal_circadian_rhythm0.98775745
95MP0002127_abnormal_cardiovascular_syste0.95511982
96MP0010678_abnormal_skin_adnexa0.95268840
97MP0004811_abnormal_neuron_physiology0.94968092
98MP0002971_abnormal_brown_adipose0.93565873
99MP0005195_abnormal_posterior_eye0.91943873
100MP0001346_abnormal_lacrimal_gland0.89797360
101MP0006072_abnormal_retinal_apoptosis0.87876250
102MP0004147_increased_porphyrin_level0.87475399
103MP0004043_abnormal_pH_regulation0.87169291
104MP0005266_abnormal_metabolism0.85717077
105MP0000026_abnormal_inner_ear0.84354111
106MP0004036_abnormal_muscle_relaxation0.84146570
107MP0005253_abnormal_eye_physiology0.83927667
108MP0001958_emphysema0.83123507
109MP0001177_atelectasis0.83046865
110MP0006276_abnormal_autonomic_nervous0.82718326
111MP0000762_abnormal_tongue_morphology0.82537793
112MP0000566_synostosis0.82431794
113MP0000003_abnormal_adipose_tissue0.82199616
114MP0000383_abnormal_hair_follicle0.82094419
115MP0005645_abnormal_hypothalamus_physiol0.81680720
116MP0009250_abnormal_appendicular_skeleto0.80978635
117MP0005670_abnormal_white_adipose0.80441887
118MP0003938_abnormal_ear_development0.80324708
119MP0005167_abnormal_blood-brain_barrier0.77519750
120MP0002822_catalepsy0.77279630
121MP0010030_abnormal_orbit_morphology0.76553850
122MP0004085_abnormal_heartbeat0.75997142
123MP0005375_adipose_tissue_phenotype0.75555728
124MP0008438_abnormal_cutaneous_collagen0.75408481
125MP0002295_abnormal_pulmonary_circulatio0.75363624
126MP0004185_abnormal_adipocyte_glucose0.73544003
127MP0003137_abnormal_impulse_conducting0.71210396
128MP0003279_aneurysm0.70883013
129MP0001984_abnormal_olfaction0.70743189
130MP0000647_abnormal_sebaceous_gland0.69732266
131MP0008775_abnormal_heart_ventricle0.68291029
132MP0005666_abnormal_adipose_tissue0.67837324
133MP0003937_abnormal_limbs/digits/tail_de0.66784769
134MP0000631_abnormal_neuroendocrine_gland0.64388463
135MP0002108_abnormal_muscle_morphology0.63761231
136MP0001348_abnormal_lacrimal_gland0.63402033
137MP0001943_abnormal_respiration0.63007671
138MP0001664_abnormal_digestion0.61765010
139MP0003075_altered_response_to0.61200385
140MP0003045_fibrosis0.60586735
141MP0005058_abnormal_lysosome_morphology0.60562791
142MP0003861_abnormal_nervous_system0.60232895
143MP0003221_abnormal_cardiomyocyte_apopto0.60163129
144MP0008874_decreased_physiological_sensi0.59715630
145MP0005451_abnormal_body_composition0.59257308
146MP0005165_increased_susceptibility_to0.54169258
147MP0005166_decreased_susceptibility_to0.53344169
148MP0005535_abnormal_body_temperature0.51587704

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)7.87544184
2Exercise-induced muscle cramps (HP:0003710)6.69641613
3Neurofibrillary tangles (HP:0002185)5.82427893
4Degeneration of the lateral corticospinal tracts (HP:0002314)5.60129736
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.60129736
6Myopathic facies (HP:0002058)5.39957515
7Distal arthrogryposis (HP:0005684)5.07837759
8EMG: myopathic abnormalities (HP:0003458)4.99804066
9Calf muscle hypertrophy (HP:0008981)4.74390789
10Centrally nucleated skeletal muscle fibers (HP:0003687)4.57577821
11Cerebral inclusion bodies (HP:0100314)4.43973815
12Abnormality of skeletal muscle fiber size (HP:0012084)4.40222901
13Abnormality of the corticospinal tract (HP:0002492)4.32847452
14Myoglobinuria (HP:0002913)4.25303733
15Rhabdomyolysis (HP:0003201)4.23580063
16Ulnar deviation of the wrist (HP:0003049)4.20122833
17Abnormality of the calf musculature (HP:0001430)4.18884908
18Neck muscle weakness (HP:0000467)4.15362114
19Myokymia (HP:0002411)4.06410787
20Sensory axonal neuropathy (HP:0003390)4.05495421
21Supranuclear gaze palsy (HP:0000605)3.94445501
22Distal lower limb muscle weakness (HP:0009053)3.92143753
23Increased variability in muscle fiber diameter (HP:0003557)3.83947476
24Increased connective tissue (HP:0009025)3.81520184
25Peripheral hypomyelination (HP:0007182)3.76969459
26Subaortic stenosis (HP:0001682)3.75395158
27Abnormality of the left ventricular outflow tract (HP:0011103)3.75395158
28Difficulty running (HP:0009046)3.70629874
29Muscle stiffness (HP:0003552)3.63058626
30Parakeratosis (HP:0001036)3.56439732
31Calcaneovalgus deformity (HP:0001848)3.52905814
32Rimmed vacuoles (HP:0003805)3.48474506
33Sudden death (HP:0001699)3.47341892
34Cerebral hypomyelination (HP:0006808)3.44609054
35Asymmetric septal hypertrophy (HP:0001670)3.44524809
36Spastic gait (HP:0002064)3.44502397
37Myotonia (HP:0002486)3.42535328
38Megalencephaly (HP:0001355)3.41122306
39Bundle branch block (HP:0011710)3.38872808
40Dysmetria (HP:0001310)3.20204177
41Ankle clonus (HP:0011448)3.19413190
42Frequent falls (HP:0002359)3.17673149
43Insidious onset (HP:0003587)3.17093731
44Termporal pattern (HP:0011008)3.17093731
45Deformed tarsal bones (HP:0008119)3.16559863
46Onion bulb formation (HP:0003383)3.11597971
47Retinal dysplasia (HP:0007973)3.10424134
48Mildly elevated creatine phosphokinase (HP:0008180)3.04358493
49Intention tremor (HP:0002080)3.01853941
50EMG: neuropathic changes (HP:0003445)3.00939516
51Focal motor seizures (HP:0011153)2.95488333
52Absent phalangeal crease (HP:0006109)2.93846561
53Alacrima (HP:0000522)2.91210799
54Distal lower limb amyotrophy (HP:0008944)2.87325873
55Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.84305274
56Aplasia involving bones of the extremities (HP:0009825)2.81058003
57Aplasia involving bones of the upper limbs (HP:0009823)2.81058003
58Aplasia of the phalanges of the hand (HP:0009802)2.81058003
59Areflexia of lower limbs (HP:0002522)2.80580298
60Abnormality of glycolysis (HP:0004366)2.78973360
61Increased serum pyruvate (HP:0003542)2.78973360
62Slender build (HP:0001533)2.78046217
63Akinesia (HP:0002304)2.74734549
64Spinal rigidity (HP:0003306)2.68381580
65Scanning speech (HP:0002168)2.64412158
66Epileptic encephalopathy (HP:0200134)2.63485430
67Malignant hyperthermia (HP:0002047)2.61310723
68Hypoplastic pelvis (HP:0008839)2.61107827
69Lower limb amyotrophy (HP:0007210)2.59585208
70Abnormal auditory evoked potentials (HP:0006958)2.58274820
71Clumsiness (HP:0002312)2.56735506
72Atonic seizures (HP:0010819)2.53238094
73Generalized muscle weakness (HP:0003324)2.53185644
74Slow saccadic eye movements (HP:0000514)2.52483409
75Leukodystrophy (HP:0002415)2.50492269
76Bulbar palsy (HP:0001283)2.50260211
77Scapular winging (HP:0003691)2.50049186
78Pheochromocytoma (HP:0002666)2.47906087
79Difficulty climbing stairs (HP:0003551)2.43682781
80Action tremor (HP:0002345)2.38821993
81Limb-girdle muscle atrophy (HP:0003797)2.34877940
82Heart block (HP:0012722)2.34214729
83Lower limb muscle weakness (HP:0007340)2.32364274
84Abnormal finger flexion creases (HP:0006143)2.32315575
85Abnormal atrioventricular conduction (HP:0005150)2.32100400
86Weak cry (HP:0001612)2.29311024
87Dilated cardiomyopathy (HP:0001644)2.28954317
88Ventricular tachycardia (HP:0004756)2.23361534
89Decreased lacrimation (HP:0000633)2.22928542
90Focal seizures (HP:0007359)2.21194033
91Thickened helices (HP:0000391)2.20397932
92Neuroendocrine neoplasm (HP:0100634)2.15655890
93Spastic paraparesis (HP:0002313)2.13792657
94Increased circulating renin level (HP:0000848)2.13237531
95Urinary urgency (HP:0000012)2.13110868
96Coronal craniosynostosis (HP:0004440)2.11385901
97Infantile muscular hypotonia (HP:0008947)2.10314559
98CNS hypomyelination (HP:0003429)2.10195474
99Lipoatrophy (HP:0100578)2.09800446
100Split foot (HP:0001839)2.08199826
101Muscle fiber splitting (HP:0003555)2.06931377
102Humeroradial synostosis (HP:0003041)2.06859177
103Synostosis involving the elbow (HP:0003938)2.06859177
104Absent septum pellucidum (HP:0001331)2.06667589
105Hip contracture (HP:0003273)2.06185035
106Nemaline bodies (HP:0003798)2.04820279
107Type II lissencephaly (HP:0007260)2.03238456
108Muscle hypertrophy of the lower extremities (HP:0008968)2.03174887
109Stridor (HP:0010307)2.02280409
110Waddling gait (HP:0002515)2.01532416
111Abnormality of the calcaneus (HP:0008364)1.97215361
112Foot dorsiflexor weakness (HP:0009027)1.95972429
113Premature skin wrinkling (HP:0100678)1.95495896
114Progressive cerebellar ataxia (HP:0002073)1.93953447
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93177036
116Congenital ichthyosiform erythroderma (HP:0007431)1.93050824
117Muscle fiber inclusion bodies (HP:0100299)1.92573726
118Hyporeflexia of lower limbs (HP:0002600)1.91823603
119Muscular dystrophy (HP:0003560)1.90655669
120Anteriorly placed anus (HP:0001545)1.90000952
121Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.89904487
122Limb-girdle muscle weakness (HP:0003325)1.89569091
123Gowers sign (HP:0003391)1.88194346
124Fatigable weakness (HP:0003473)1.87606923
125Abnormality of the neuromuscular junction (HP:0003398)1.87606923
126Morphological abnormality of the inner ear (HP:0011390)1.87418024
127Respiratory insufficiency due to muscle weakness (HP:0002747)1.87383049
128Ventricular arrhythmia (HP:0004308)1.87374724
129Bowel incontinence (HP:0002607)1.86701297
130Abnormality of the shoulder girdle musculature (HP:0001435)1.85068210
131Broad-based gait (HP:0002136)1.83415880
132Autoamputation (HP:0001218)1.83153220
133Round ear (HP:0100830)1.82586162
134Partial agenesis of the corpus callosum (HP:0001338)1.82248701
135Dysdiadochokinesis (HP:0002075)1.81374852
136Poor speech (HP:0002465)1.81069417
137Progressive muscle weakness (HP:0003323)1.80738570
138Abnormality of the middle phalanges of the toes (HP:0010183)1.80261065
139Hyperkalemia (HP:0002153)1.79819041
140Proximal amyotrophy (HP:0007126)1.79657222
141Clonus (HP:0002169)1.79142419
142Generalized myoclonic seizures (HP:0002123)1.78296485
143Vaginal atresia (HP:0000148)1.76701858
144Segmental peripheral demyelination/remyelination (HP:0003481)1.76665970
145Hammertoe (HP:0001765)1.76256549
146Exercise-induced myalgia (HP:0003738)1.75664731
147Abnormality of the foot musculature (HP:0001436)1.75510035
148Urinary bladder sphincter dysfunction (HP:0002839)1.75016227
149Achilles tendon contracture (HP:0001771)1.74402031
150Hypoplasia of the iris (HP:0007676)1.73084277
151Cerebral hemorrhage (HP:0001342)1.71818306
152Genital tract atresia (HP:0001827)1.69710195
153Abnormal large intestine physiology (HP:0012700)1.69568960
154Ragged-red muscle fibers (HP:0003200)1.68354429
155Distal sensory impairment (HP:0002936)1.68094367
156Abnormality of the phalanges of the 2nd finger (HP:0009541)1.67740406
157Morphological abnormality of the pyramidal tract (HP:0002062)1.67620304
158Nonprogressive disorder (HP:0003680)1.67521809
159Abnormality of the septum pellucidum (HP:0007375)1.66191212
160Urinary incontinence (HP:0000020)1.65493613
161Obstructive sleep apnea (HP:0002870)1.65445210
162Dialeptic seizures (HP:0011146)1.64171231
163Fetal akinesia sequence (HP:0001989)1.63636800
164Steppage gait (HP:0003376)1.61989477
165Paraparesis (HP:0002385)1.61559688
166Decreased motor nerve conduction velocity (HP:0003431)1.61171095
167Atrioventricular block (HP:0001678)1.59750811
168Abnormality of the musculature of the pelvis (HP:0001469)1.56827344
169Abnormality of the hip-girdle musculature (HP:0001445)1.56827344
170Ventricular fibrillation (HP:0001663)1.54896658
171Metatarsus adductus (HP:0001840)1.54701957
172Rapidly progressive (HP:0003678)1.52896739
173Limited hip movement (HP:0008800)1.52334919
174Abnormality of the Achilles tendon (HP:0005109)1.51062484
175Generalized tonic-clonic seizures (HP:0002069)1.50943991
176Generalized amyotrophy (HP:0003700)1.50042791
177Shoulder girdle muscle weakness (HP:0003547)1.47405550
178Exercise intolerance (HP:0003546)1.46235891
179Pelvic girdle muscle weakness (HP:0003749)1.41255843
180Diplopia (HP:0000651)1.39920883
181Abnormality of binocular vision (HP:0011514)1.39920883
182Congenital hip dislocation (HP:0001374)1.39492663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.45132620
2STK395.22906207
3OXSR13.93577430
4EPHB12.83608068
5TNIK2.60339613
6CDK192.59469879
7BCR2.33864005
8EPHA42.28212531
9PKN12.17759041
10LIMK12.06765959
11WNK42.00609066
12MAPKAPK51.98944498
13PIK3CG1.94366822
14CASK1.91137816
15PRPF4B1.90114868
16NTRK11.85489082
17UHMK11.81201832
18PNCK1.80213185
19PAK61.78680116
20PHKG11.71205428
21PHKG21.71205428
22MARK11.65820174
23FGFR21.62925010
24PBK1.59783315
25MET1.59454043
26WNK11.57641201
27RIPK11.57388532
28ROCK21.54767872
29NEK61.51334944
30ICK1.48290931
31FGR1.47292846
32MAP2K31.45730072
33CAMK2B1.44267548
34NTRK21.41508728
35TESK21.36174958
36CSNK1G31.33823653
37SGK4941.32867398
38SGK2231.32867398
39NTRK31.30292845
40TYRO31.29164919
41CSNK1A1L1.24858567
42CSNK1G21.18855349
43CAMK2D1.17849734
44MAP2K41.17843733
45MAP3K71.15593752
46TRIB31.15465558
47CDK51.12544167
48LATS21.12406413
49PAK31.11976299
50MAPK131.09884987
51MOS1.09131893
52TESK11.08033059
53CDK141.07900854
54MAP3K91.07356804
55MAPKAPK31.05515356
56CAMK2G1.02926322
57MINK11.00269941
58CDK150.98094777
59MUSK0.97984970
60CAMK2A0.97621772
61CSNK1G10.96296330
62CDK180.95092449
63KSR20.93570245
64AKT30.90831634
65CAMK10.89129093
66DDR20.88760952
67MAP3K40.88654315
68PRKD30.88627892
69CDK11A0.87371921
70MAP3K110.86522712
71LMTK20.86424477
72MARK20.84462191
73ARAF0.83994805
74OBSCN0.79359909
75DYRK20.76887367
76CLK10.76385016
77PLK20.76228128
78MST40.75936095
79DYRK1B0.74843280
80MAP2K70.74207223
81TAOK20.72311689
82CAMK40.69763529
83PRKCE0.68020406
84SGK30.67782309
85PDPK10.66741943
86MAP2K60.65943218
87PRKCQ0.64289135
88IRAK20.64282426
89NME10.62761925
90SIK10.60693247
91CCNB10.60272630
92AKT20.59994661
93DMPK0.58709882
94PRKD10.57488878
95FYN0.57069055
96MAP3K20.55574604
97DAPK20.55103568
98EEF2K0.53544093
99PRKCG0.53431541
100MAPK40.52773601
101GRK50.52604299
102ROCK10.52135264
103MAP2K10.51626602
104PRKAA10.51398888
105PDGFRA0.51323289
106PINK10.50429527
107STK380.50329278
108PTK2B0.50302915
109MAP3K10.49415591
110PRKCH0.48422258
111DYRK1A0.47240589
112CAMKK10.46745439
113MYLK0.46477815
114CAMK1G0.46292603
115MAPK100.46117183
116SGK20.44801898
117PRKG10.43699434
118BMPR1B0.43568847
119NEK90.43254560
120PIK3CA0.42450343
121STK110.41966187
122PRKAA20.41641003
123BCKDK0.41422514
124MAP3K130.40878523
125DAPK30.40237330
126SGK10.39818387
127MAPK120.39537253
128BMX0.39421388
129BRAF0.39208296
130MAPK70.38595675
131RPS6KA30.37707879
132PRKACB0.37208268
133CSNK1A10.36411144
134TRPM70.34433964
135CSNK1D0.34270107
136PTK20.33952830
137PDK10.33709499
138ABL20.31397814
139PRKACA0.31190573
140PAK10.30801294
141RPS6KA20.29491362
142NEK10.28619039
143PRKD20.28518620

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.57509112
2Steroid biosynthesis_Homo sapiens_hsa001003.93234935
3Fatty acid elongation_Homo sapiens_hsa000623.18059525
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.17368136
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.00174960
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95977936
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.44641589
8Ether lipid metabolism_Homo sapiens_hsa005652.25358068
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10853096
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05338356
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92814445
12Axon guidance_Homo sapiens_hsa043601.88461138
13Oxidative phosphorylation_Homo sapiens_hsa001901.84788143
14GABAergic synapse_Homo sapiens_hsa047271.84762986
15Glutamatergic synapse_Homo sapiens_hsa047241.81759859
16Circadian rhythm_Homo sapiens_hsa047101.77473277
17Synaptic vesicle cycle_Homo sapiens_hsa047211.77167631
18Glucagon signaling pathway_Homo sapiens_hsa049221.73673290
19Nicotine addiction_Homo sapiens_hsa050331.66147394
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65355150
21Sulfur metabolism_Homo sapiens_hsa009201.63853786
22Insulin signaling pathway_Homo sapiens_hsa049101.56076608
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55676043
24Morphine addiction_Homo sapiens_hsa050321.51049620
25Serotonergic synapse_Homo sapiens_hsa047261.50719477
26Carbon metabolism_Homo sapiens_hsa012001.50201898
27Circadian entrainment_Homo sapiens_hsa047131.45235255
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44080835
29Pentose phosphate pathway_Homo sapiens_hsa000301.40465638
30Arginine biosynthesis_Homo sapiens_hsa002201.39928244
31Sphingolipid metabolism_Homo sapiens_hsa006001.34906991
32Collecting duct acid secretion_Homo sapiens_hsa049661.33880839
33Salivary secretion_Homo sapiens_hsa049701.32637768
34Alzheimers disease_Homo sapiens_hsa050101.31181549
35Parkinsons disease_Homo sapiens_hsa050121.27883622
36Long-term depression_Homo sapiens_hsa047301.27618144
37Nitrogen metabolism_Homo sapiens_hsa009101.27208016
38Gastric acid secretion_Homo sapiens_hsa049711.22891706
39Cardiac muscle contraction_Homo sapiens_hsa042601.21258829
40Vibrio cholerae infection_Homo sapiens_hsa051101.20091887
41Butanoate metabolism_Homo sapiens_hsa006501.19670639
42Dopaminergic synapse_Homo sapiens_hsa047281.17900007
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17655403
44Phototransduction_Homo sapiens_hsa047441.16748060
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16468133
46Cholinergic synapse_Homo sapiens_hsa047251.14603585
47Fructose and mannose metabolism_Homo sapiens_hsa000511.12005921
48Olfactory transduction_Homo sapiens_hsa047401.11043969
49AMPK signaling pathway_Homo sapiens_hsa041521.10227537
50Cocaine addiction_Homo sapiens_hsa050301.01860678
51Biosynthesis of amino acids_Homo sapiens_hsa012301.00940616
52Vitamin B6 metabolism_Homo sapiens_hsa007501.00903694
53Renal cell carcinoma_Homo sapiens_hsa052110.99840422
54Protein export_Homo sapiens_hsa030600.99488758
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97375007
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96841545
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95143254
58Tight junction_Homo sapiens_hsa045300.95047823
59Long-term potentiation_Homo sapiens_hsa047200.93782331
60Amphetamine addiction_Homo sapiens_hsa050310.93538889
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91764668
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.91416673
63Pyruvate metabolism_Homo sapiens_hsa006200.90309205
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.89172627
65Glioma_Homo sapiens_hsa052140.88187228
66Insulin resistance_Homo sapiens_hsa049310.88164426
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88133038
68Gap junction_Homo sapiens_hsa045400.87082237
69Fatty acid biosynthesis_Homo sapiens_hsa000610.87021615
70Insulin secretion_Homo sapiens_hsa049110.86840341
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86718570
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85419888
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83938474
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83417839
75Renin secretion_Homo sapiens_hsa049240.82554507
76Focal adhesion_Homo sapiens_hsa045100.82420157
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.82308484
78Oxytocin signaling pathway_Homo sapiens_hsa049210.81420245
79ErbB signaling pathway_Homo sapiens_hsa040120.81022595
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81002452
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.80232177
82Linoleic acid metabolism_Homo sapiens_hsa005910.80141177
83Taste transduction_Homo sapiens_hsa047420.79489650
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78136917
85Fatty acid metabolism_Homo sapiens_hsa012120.77158517
86Calcium signaling pathway_Homo sapiens_hsa040200.75939019
87Arginine and proline metabolism_Homo sapiens_hsa003300.75619496
88Phenylalanine metabolism_Homo sapiens_hsa003600.72439625
89Ras signaling pathway_Homo sapiens_hsa040140.71276213
90Endocytosis_Homo sapiens_hsa041440.71123982
91Pancreatic secretion_Homo sapiens_hsa049720.68878096
92VEGF signaling pathway_Homo sapiens_hsa043700.68143667
93cAMP signaling pathway_Homo sapiens_hsa040240.66612342
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65638724
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65172808
96Prion diseases_Homo sapiens_hsa050200.65092331
97Estrogen signaling pathway_Homo sapiens_hsa049150.64949364
98Melanogenesis_Homo sapiens_hsa049160.63783911
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63409268
100GnRH signaling pathway_Homo sapiens_hsa049120.61863728
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.61726776
102Huntingtons disease_Homo sapiens_hsa050160.60929760
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60456254
104Hedgehog signaling pathway_Homo sapiens_hsa043400.59832823
105Ovarian steroidogenesis_Homo sapiens_hsa049130.59552434
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59312570
107Dilated cardiomyopathy_Homo sapiens_hsa054140.59296563
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57486591
109Rheumatoid arthritis_Homo sapiens_hsa053230.56039218
110Lysosome_Homo sapiens_hsa041420.56007724
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55711506
112Dorso-ventral axis formation_Homo sapiens_hsa043200.55162951
113Bile secretion_Homo sapiens_hsa049760.55112685
114Mineral absorption_Homo sapiens_hsa049780.54792626
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.53148200
116Histidine metabolism_Homo sapiens_hsa003400.52911563
117beta-Alanine metabolism_Homo sapiens_hsa004100.52289432
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52271314
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51536501
120Galactose metabolism_Homo sapiens_hsa000520.50553153
121Fatty acid degradation_Homo sapiens_hsa000710.49982348
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49372133
123Choline metabolism in cancer_Homo sapiens_hsa052310.48889700
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46745437
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45857813
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.45336489
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43994691
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43178135
129Phagosome_Homo sapiens_hsa041450.43049146
130ECM-receptor interaction_Homo sapiens_hsa045120.42618298
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42052856
132PPAR signaling pathway_Homo sapiens_hsa033200.39517102
133MAPK signaling pathway_Homo sapiens_hsa040100.39406210
134Amoebiasis_Homo sapiens_hsa051460.38973566
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38114408
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37992133
137Wnt signaling pathway_Homo sapiens_hsa043100.37836688
138Propanoate metabolism_Homo sapiens_hsa006400.37621055
139Starch and sucrose metabolism_Homo sapiens_hsa005000.34216285
140mTOR signaling pathway_Homo sapiens_hsa041500.34109915
141Thyroid hormone synthesis_Homo sapiens_hsa049180.32066363

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