SHISA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pseudogenes of this gene are found on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.50708487
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.49385704
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.49385704
4antigen processing and presentation of endogenous antigen (GO:0019883)6.76564917
5negative T cell selection (GO:0043383)6.56715265
6negative thymic T cell selection (GO:0045060)6.51787970
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.21074687
8regulation of gamma-delta T cell differentiation (GO:0045586)5.99740917
9positive thymic T cell selection (GO:0045059)5.96137347
10negative regulation of cell killing (GO:0031342)5.91204153
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.91204153
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.74641315
13response to interleukin-15 (GO:0070672)5.68479704
14cellular response to interleukin-15 (GO:0071350)5.55712357
15regulation of gamma-delta T cell activation (GO:0046643)5.53337660
16regulation of isotype switching to IgG isotypes (GO:0048302)5.53202790
17thymic T cell selection (GO:0045061)5.41198885
18regulation of T cell tolerance induction (GO:0002664)5.23926810
19positive T cell selection (GO:0043368)5.22524559
20T cell migration (GO:0072678)5.19805253
21leukocyte aggregation (GO:0070486)5.13626785
22regulation of B cell receptor signaling pathway (GO:0050855)5.09305242
23T cell selection (GO:0045058)5.03171378
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.98657273
25positive regulation by organism of defense response of other organism involved in symbiotic interact4.98657273
26modulation by symbiont of host immune response (GO:0052553)4.98657273
27positive regulation by symbiont of host defense response (GO:0052509)4.98657273
28modulation by symbiont of host defense response (GO:0052031)4.98657273
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.98657273
30interferon-gamma production (GO:0032609)4.91594105
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.87103696
32positive regulation of tolerance induction (GO:0002645)4.49082778
33regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.40007565
34T cell receptor signaling pathway (GO:0050852)4.38621897
35detection of other organism (GO:0098543)4.35605609
36detection of bacterium (GO:0016045)4.34899072
37antigen processing and presentation via MHC class Ib (GO:0002475)4.31279735
38regulation of alpha-beta T cell proliferation (GO:0046640)4.29684153
39T cell costimulation (GO:0031295)4.26260427
40positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.25871583
41lymphocyte costimulation (GO:0031294)4.21455126
42regulation of interleukin-12 biosynthetic process (GO:0045075)4.21049459
43regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.11345881
44regulation of tolerance induction (GO:0002643)4.10471442
45antigen receptor-mediated signaling pathway (GO:0050851)4.10274912
46response to interferon-alpha (GO:0035455)4.06511269
47tolerance induction (GO:0002507)4.06498040
48neutrophil activation involved in immune response (GO:0002283)4.01991693
49response to type I interferon (GO:0034340)4.00611133
50type I interferon signaling pathway (GO:0060337)3.97166310
51cellular response to type I interferon (GO:0071357)3.97166310
52positive regulation of alpha-beta T cell proliferation (GO:0046641)3.97144306
53leukocyte migration involved in inflammatory response (GO:0002523)3.97139194
54regulation of T cell receptor signaling pathway (GO:0050856)3.95198145
55regulation of B cell differentiation (GO:0045577)3.94143069
56regulation of regulatory T cell differentiation (GO:0045589)3.89673762
57regulation of type I interferon-mediated signaling pathway (GO:0060338)3.81434084
58B cell receptor signaling pathway (GO:0050853)3.75207295
59regulation of response to interferon-gamma (GO:0060330)3.72775269
60sequestering of actin monomers (GO:0042989)3.71425711
61respiratory burst (GO:0045730)3.69914645
62positive regulation of isotype switching (GO:0045830)3.68442789
63regulation of interleukin-2 biosynthetic process (GO:0045076)3.68301957
64positive regulation of interleukin-2 production (GO:0032743)3.66526328
65macrophage activation involved in immune response (GO:0002281)3.63530634
66detection of external biotic stimulus (GO:0098581)3.62247436
67regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.61645934
68regulation of isotype switching (GO:0045191)3.57343047
69mast cell activation (GO:0045576)3.55181298
70interferon-gamma-mediated signaling pathway (GO:0060333)3.52021285
71regulation of natural killer cell mediated immunity (GO:0002715)3.50453423
72regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.50453423
73leukocyte cell-cell adhesion (GO:0007159)3.50298708
74positive regulation of natural killer cell mediated immunity (GO:0002717)3.48627991
75positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.48627991
76NIK/NF-kappaB signaling (GO:0038061)3.45604955
77response to host immune response (GO:0052572)3.40957715
78response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.40957715
79response to peptidoglycan (GO:0032494)3.40112949
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.39078318
81negative regulation of leukocyte mediated immunity (GO:0002704)3.37686118
82regulation of interferon-beta biosynthetic process (GO:0045357)3.35060309
83positive regulation of humoral immune response (GO:0002922)3.32310644
84JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.32279216
85regulation of immunoglobulin mediated immune response (GO:0002889)3.30475976
86neutrophil activation (GO:0042119)3.29270937
87regulation of B cell mediated immunity (GO:0002712)3.27895287
88response to host (GO:0075136)3.25998593
89response to host defenses (GO:0052200)3.25998593
90response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.25998593
91cellular response to interferon-beta (GO:0035458)3.25739362
92positive regulation of DNA recombination (GO:0045911)3.25490853
93regulation of leukocyte mediated cytotoxicity (GO:0001910)3.24098862
94positive regulation of B cell differentiation (GO:0045579)3.23492348
95positive regulation of B cell mediated immunity (GO:0002714)3.22151673
96positive regulation of immunoglobulin mediated immune response (GO:0002891)3.22151673
97positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.21654717
98Arp2/3 complex-mediated actin nucleation (GO:0034314)3.20574495
99activated T cell proliferation (GO:0050798)3.18522231
100negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.17286351
101negative regulation of phagocytosis (GO:0050765)3.16040954
102T cell homeostasis (GO:0043029)3.15411820
103negative regulation of T cell mediated immunity (GO:0002710)3.14179099
104natural killer cell activation (GO:0030101)3.13822589
105detection of molecule of bacterial origin (GO:0032490)3.12522233
106detection of biotic stimulus (GO:0009595)3.12511227
107lymph node development (GO:0048535)3.10734863
108myeloid dendritic cell activation (GO:0001773)3.10409811
109positive regulation of immunoglobulin production (GO:0002639)3.08347303
110regulation of immunoglobulin production (GO:0002637)3.08265963
111negative regulation of innate immune response (GO:0045824)3.07189227
112lymphocyte migration (GO:0072676)3.06316994
113immunoglobulin mediated immune response (GO:0016064)3.06077059
114granulocyte activation (GO:0036230)3.05732455
115negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.05298030
116immune response-activating cell surface receptor signaling pathway (GO:0002429)3.04390270
117regulation of defense response to virus by virus (GO:0050690)3.03003001
118regulation of myeloid leukocyte mediated immunity (GO:0002886)3.01678849
119regulation of mast cell degranulation (GO:0043304)3.01622523
120mature B cell differentiation (GO:0002335)3.01159403
121negative regulation of interleukin-12 production (GO:0032695)3.00851916
122alpha-beta T cell activation (GO:0046631)3.00279241
123T cell differentiation (GO:0030217)2.99805454
124regulation of cell killing (GO:0031341)2.98757533
125negative regulation of T cell receptor signaling pathway (GO:0050860)2.98626928
126positive regulation of Cdc42 GTPase activity (GO:0043089)2.98323067
127negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.98291331
128positive regulation of interleukin-8 secretion (GO:2000484)2.97256876
129negative regulation of type 2 immune response (GO:0002829)2.97131040
130positive regulation of T cell mediated cytotoxicity (GO:0001916)2.96758740
131negative regulation of lymphocyte mediated immunity (GO:0002707)2.96520009
132regulation of T cell mediated cytotoxicity (GO:0001914)2.96164755
133negative regulation of erythrocyte differentiation (GO:0045647)2.94937227
134regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94348608
135response to interferon-beta (GO:0035456)2.94167483
136protein localization to endosome (GO:0036010)2.91506780
137positive regulation of cell killing (GO:0031343)2.90796964
138T cell activation (GO:0042110)2.90275466
139regulation of leukocyte degranulation (GO:0043300)2.86902027
140barbed-end actin filament capping (GO:0051016)2.80401152
141negative regulation of glycoprotein biosynthetic process (GO:0010561)2.80206030
142modulation by virus of host process (GO:0019054)2.78895456
143negative regulation of viral genome replication (GO:0045071)2.76450922
144positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.71338953
145cellular response to virus (GO:0098586)2.67093702
146regulation of regulated secretory pathway (GO:1903305)2.66250774
147myeloid cell activation involved in immune response (GO:0002275)2.65830320
148regulation of mast cell activation involved in immune response (GO:0033006)2.61189148
149negative regulation of cytokine production involved in immune response (GO:0002719)2.60585621
150virion assembly (GO:0019068)2.60461078
151signal complex assembly (GO:0007172)2.59470165
152positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.55961345
153modulation by symbiont of host cellular process (GO:0044068)2.55347606
154cellular extravasation (GO:0045123)2.53032434
155pentose-phosphate shunt (GO:0006098)2.52968144
156viral protein processing (GO:0019082)2.52398856
157interferon-gamma secretion (GO:0072643)2.52183147
158regulation of T-helper 2 cell differentiation (GO:0045628)2.50794280
159protein maturation by protein folding (GO:0022417)2.50753815
160negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.49907635
161amino sugar catabolic process (GO:0046348)2.47747744
162negative regulation of glycoprotein metabolic process (GO:1903019)2.47596702
163negative regulation of viral entry into host cell (GO:0046597)2.46298887
164leukocyte degranulation (GO:0043299)2.45499004
165dendritic cell chemotaxis (GO:0002407)2.43775928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.85781528
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.55759582
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.45856268
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.47058749
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.01979296
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.46793996
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.46778303
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.41206267
9STAT4_19710469_ChIP-ChIP_TH1__Mouse3.37532209
10* RUNX_20019798_ChIP-Seq_JUKART_Human3.31099302
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.18394779
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.18222122
13MYC_22102868_ChIP-Seq_BL_Human3.12543178
14MYB_26560356_Chip-Seq_TH2_Human3.02388691
15MAF_26560356_Chip-Seq_TH1_Human2.85147982
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.76450845
17MYB_26560356_Chip-Seq_TH1_Human2.58182562
18* UTX_26944678_Chip-Seq_JUKART_Human2.45005812
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.43016231
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.42130334
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41840139
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40144877
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.36215862
24VDR_21846776_ChIP-Seq_THP-1_Human2.35427366
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33979330
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.32571714
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31160213
28SCL_19346495_ChIP-Seq_HPC-7_Human2.26410730
29SPI1_23547873_ChIP-Seq_NB4_Human2.18744106
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14331682
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13695714
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.06230311
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04422836
34ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03814765
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96266340
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.94066778
37MAF_26560356_Chip-Seq_TH2_Human1.93239995
38VDR_24763502_ChIP-Seq_THP-1_Human1.88703102
39* RACK7_27058665_Chip-Seq_MCF-7_Human1.87695850
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.83697804
41* GATA3_27048872_Chip-Seq_THYMUS_Human1.82611834
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80175189
43TCF7_22412390_ChIP-Seq_EML_Mouse1.75786561
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67334729
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.67089688
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66797877
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.63155643
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63080353
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62644781
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61163393
51P68_20966046_ChIP-Seq_HELA_Human1.58643872
52SPI1_23127762_ChIP-Seq_K562_Human1.54614647
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.53478568
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53111757
55BCOR_27268052_Chip-Seq_Bcells_Human1.49429658
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.48131643
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47491840
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.47117235
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45556782
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44498474
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42843220
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42674590
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42044659
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40071738
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39847937
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37887569
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37513573
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36784933
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.35980806
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35679046
71* KDM2B_26808549_Chip-Seq_DND41_Human1.32423930
72PU_27001747_Chip-Seq_BMDM_Mouse1.32392519
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31024918
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30545626
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30034169
76KDM2B_26808549_Chip-Seq_K562_Human1.28293222
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28117707
78* SMC4_20622854_ChIP-Seq_HELA_Human1.27384016
79* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25919664
80* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24946256
81GATA3_26560356_Chip-Seq_TH2_Human1.24210013
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24125800
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23634981
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22699655
85* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22675099
86SA1_27219007_Chip-Seq_Bcells_Human1.22022803
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20829498
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20680347
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20125384
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19199620
91* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18903424
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18726785
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18059561
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16447988
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14511284
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14332204
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11664402
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11205760
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10417176
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09733985
101SMAD_19615063_ChIP-ChIP_OVARY_Human1.09705875
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.08707604
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08200742
104* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07503429
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07320399
106CIITA_25753668_ChIP-Seq_RAJI_Human1.07151361
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07149224
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04405819
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03695380
110E2F1_20622854_ChIP-Seq_HELA_Human1.03621049
111GATA1_22025678_ChIP-Seq_K562_Human1.02428591
112PHF8_20622854_ChIP-Seq_HELA_Human1.02072344
113YY1_22570637_ChIP-Seq_MALME-3M_Human1.00862923
114CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99837929
115CTCF_21964334_Chip-Seq_Bcells_Human0.99761276
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99464284
117VDR_23849224_ChIP-Seq_CD4+_Human0.97873059
118* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94908123
119GATA1_19941827_ChIP-Seq_MEL_Mouse0.94688689
120* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94172041
121* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92945269
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90792596
123FOXP3_21729870_ChIP-Seq_TREG_Human0.87111866
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.82419491
125PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82285426
126LXR_22292898_ChIP-Seq_THP-1_Human0.80779482
127* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80435469
128BCL6_27268052_Chip-Seq_Bcells_Human0.79441048
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78206757
130SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.77479363
131NCOR1_26117541_ChIP-Seq_K562_Human0.76825916
132E2F7_22180533_ChIP-Seq_HELA_Human0.76747438
133* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76028069
134* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75980786
135NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.74047689
136GATA2_21666600_ChIP-Seq_HMVEC_Human0.72033466
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71642507
138P300_27268052_Chip-Seq_Bcells_Human0.68254143
139CTCF_26484167_Chip-Seq_Bcells_Mouse0.68248136
140VDR_24787735_ChIP-Seq_THP-1_Human0.67230550
141ETS1_22383799_ChIP-Seq_G1ME_Mouse0.66189931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.66467252
2MP0005671_abnormal_response_to4.31730314
3MP0001835_abnormal_antigen_presentation4.19373678
4MP0000685_abnormal_immune_system3.98906198
5MP0009785_altered_susceptibility_to3.37561178
6MP0001800_abnormal_humoral_immune3.37522239
7MP0001790_abnormal_immune_system3.34919690
8MP0005387_immune_system_phenotype3.34919690
9MP0005000_abnormal_immune_tolerance3.12328427
10MP0002723_abnormal_immune_serum2.95088672
11MP0002420_abnormal_adaptive_immunity2.94830319
12MP0001819_abnormal_immune_cell2.90864748
13MP0002452_abnormal_antigen_presenting2.87930495
14MP0002166_altered_tumor_susceptibility2.80752001
15MP0005025_abnormal_response_to2.78683391
16MP0002398_abnormal_bone_marrow2.70427576
17MP0003436_decreased_susceptibility_to2.66504082
18MP0008260_abnormal_autophagy2.64940087
19MP0006082_CNS_inflammation2.58951620
20MP0003724_increased_susceptibility_to2.53476439
21MP0009333_abnormal_splenocyte_physiolog2.53127623
22MP0002148_abnormal_hypersensitivity_rea2.45341182
23MP0000716_abnormal_immune_system2.45082796
24MP0009840_abnormal_foam_cell2.38229630
25MP0002405_respiratory_system_inflammati2.36089829
26MP0001873_stomach_inflammation2.34385035
27MP0004858_abnormal_nervous_system2.28337343
28MP0002006_tumorigenesis2.27102956
29MP0002419_abnormal_innate_immunity2.25317607
30MP0010155_abnormal_intestine_physiology2.23586647
31MP0000689_abnormal_spleen_morphology2.21716222
32MP0002396_abnormal_hematopoietic_system2.20936582
33MP0002722_abnormal_immune_system2.20690399
34MP0004947_skin_inflammation2.10627346
35MP0000703_abnormal_thymus_morphology2.09788340
36MP0003866_abnormal_defecation2.07956623
37MP0003300_gastrointestinal_ulcer2.02561559
38MP0002653_abnormal_ependyma_morphology2.01569171
39MP0002429_abnormal_blood_cell2.01031538
40MP0002933_joint_inflammation1.96765869
41MP0003705_abnormal_hypodermis_morpholog1.91734118
42MP0005464_abnormal_platelet_physiology1.90568777
43MP0001845_abnormal_inflammatory_respons1.85790437
44MP0004510_myositis1.85249663
45MP0005451_abnormal_body_composition1.72390889
46MP0003303_peritoneal_inflammation1.69957133
47MP0001853_heart_inflammation1.61332109
48MP0003329_amyloid_beta_deposits1.57036783
49MP0004808_abnormal_hematopoietic_stem1.50539634
50MP0000465_gastrointestinal_hemorrhage1.47767877
51MP0000858_altered_metastatic_potential1.47382307
52MP0000604_amyloidosis1.39653618
53MP0003075_altered_response_to1.39230485
54MP0008469_abnormal_protein_level1.36965421
55MP0001533_abnormal_skeleton_physiology1.36238154
56MP0005310_abnormal_salivary_gland1.33556645
57MP0001958_emphysema1.33307037
58MP0005083_abnormal_biliary_tract1.28959866
59MP0008438_abnormal_cutaneous_collagen1.26327204
60MP0001542_abnormal_bone_strength1.25416130
61MP0003448_altered_tumor_morphology1.22647620
62MP0000490_abnormal_crypts_of1.17733313
63MP0005397_hematopoietic_system_phenotyp1.13577397
64MP0001545_abnormal_hematopoietic_system1.13577397
65MP0005075_abnormal_melanosome_morpholog1.10839061
66MP0001849_ear_inflammation1.06579877
67MP0001851_eye_inflammation1.06156500
68MP0008004_abnormal_stomach_pH1.05386395
69MP0003806_abnormal_nucleotide_metabolis1.05321363
70MP0005174_abnormal_tail_pigmentation1.04903843
71MP0002998_abnormal_bone_remodeling1.01919747
72MP0004883_abnormal_blood_vessel1.00212628
73MP0005023_abnormal_wound_healing0.99288243
74MP0003045_fibrosis0.99277965
75MP0005058_abnormal_lysosome_morphology0.94612586
76MP0002019_abnormal_tumor_incidence0.92525715
77MP0002132_abnormal_respiratory_system0.92486763
78MP0005377_hearing/vestibular/ear_phenot0.91600314
79MP0003878_abnormal_ear_physiology0.91600314
80MP0009764_decreased_sensitivity_to0.89809343
81MP0000767_abnormal_smooth_muscle0.89628481
82MP0005164_abnormal_response_to0.89571497
83MP0008874_decreased_physiological_sensi0.87504640
84MP0004381_abnormal_hair_follicle0.87246871
85MP0003011_delayed_dark_adaptation0.86942112
86MP0002009_preneoplasia0.80073133
87MP0003123_paternal_imprinting0.79770444
88MP0005257_abnormal_intraocular_pressure0.79185974
89MP0002138_abnormal_hepatobiliary_system0.78204502
90MP0000343_altered_response_to0.77428936
91MP0000750_abnormal_muscle_regeneration0.76546704
92MP0002254_reproductive_system_inflammat0.76401279
93MP0006054_spinal_hemorrhage0.75809115
94MP0009763_increased_sensitivity_to0.75522536
95MP0003172_abnormal_lysosome_physiology0.74427214
96MP0005381_digestive/alimentary_phenotyp0.71470028
97MP0010352_gastrointestinal_tract_polyps0.71057834
98MP0003879_abnormal_hair_cell0.70011088
99MP0000678_abnormal_parathyroid_gland0.68316484
100MP0002136_abnormal_kidney_physiology0.67853856
101MP0001915_intracranial_hemorrhage0.67852618
102MP0009278_abnormal_bone_marrow0.67354119
103MP0009765_abnormal_xenobiotic_induced0.66061584
104MP0003191_abnormal_cellular_cholesterol0.65801272
105MP0003795_abnormal_bone_structure0.65040346
106MP0005623_abnormal_meninges_morphology0.64969694
107MP0003453_abnormal_keratinocyte_physiol0.62341999
108MP0002796_impaired_skin_barrier0.62146648
109MP0000477_abnormal_intestine_morphology0.61582683
110MP0003279_aneurysm0.61534223
111MP0001663_abnormal_digestive_system0.60765982
112MP0000249_abnormal_blood_vessel0.60444565
113MP0005390_skeleton_phenotype0.58703805
114MP0010234_abnormal_vibrissa_follicle0.57204172
115MP0003091_abnormal_cell_migration0.52786528
116MP0001191_abnormal_skin_condition0.52590946
117MP0002095_abnormal_skin_pigmentation0.51574450
118MP0000015_abnormal_ear_pigmentation0.50449432
119MP0005166_decreased_susceptibility_to0.49979143
120MP0003566_abnormal_cell_adhesion0.49436801
121MP0003828_pulmonary_edema0.48836338
122MP0001348_abnormal_lacrimal_gland0.48509804
123MP0000609_abnormal_liver_physiology0.45663835
124MP0001243_abnormal_dermal_layer0.45258714
125MP0008961_abnormal_basal_metabolism0.44017479
126MP0002693_abnormal_pancreas_physiology0.42764065
127MP0001216_abnormal_epidermal_layer0.41528493
128MP0003183_abnormal_peptide_metabolism0.39691761
129MP0008007_abnormal_cellular_replicative0.38603371
130MP0002277_abnormal_respiratory_mucosa0.37865735
131MP0000313_abnormal_cell_death0.37284749
132MP0009643_abnormal_urine_homeostasis0.35373367
133MP0000367_abnormal_coat/_hair0.34260447

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.81270042
2Recurrent bronchitis (HP:0002837)5.61709482
3T lymphocytopenia (HP:0005403)5.60532994
4Abnormality of T cell number (HP:0011839)5.44005359
5Chronic otitis media (HP:0000389)5.42719480
6Myositis (HP:0100614)4.98974208
7IgM deficiency (HP:0002850)4.79496689
8Nasal polyposis (HP:0100582)4.76253401
9Abnormality of T cells (HP:0002843)4.60889030
10Eczematoid dermatitis (HP:0000976)4.42760487
11Abnormality of the nasal mucosa (HP:0000433)4.40627788
12Stomatitis (HP:0010280)4.39602854
13Recurrent fungal infections (HP:0002841)4.39567317
14Recurrent cutaneous fungal infections (HP:0011370)4.19777269
15Chronic mucocutaneous candidiasis (HP:0002728)4.19777269
16Recurrent viral infections (HP:0004429)4.14316160
17Recurrent abscess formation (HP:0002722)4.03530502
18IgG deficiency (HP:0004315)4.01864130
19Severe combined immunodeficiency (HP:0004430)3.96410325
20Pustule (HP:0200039)3.91035714
21Panhypogammaglobulinemia (HP:0003139)3.86598863
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.86128647
23Combined immunodeficiency (HP:0005387)3.76751571
24Lymphopenia (HP:0001888)3.74645701
25Agammaglobulinemia (HP:0004432)3.73435525
26Abnormality of T cell physiology (HP:0011840)3.60301710
27Abnormality of cells of the lymphoid lineage (HP:0012140)3.58093621
28Chronic diarrhea (HP:0002028)3.55886725
29Orchitis (HP:0100796)3.45784596
30Optic neuritis (HP:0100653)3.44389843
31Retrobulbar optic neuritis (HP:0100654)3.44389843
32Thrombocytosis (HP:0001894)3.35242468
33Meningitis (HP:0001287)3.32544879
34Vasculitis (HP:0002633)3.32227671
35Peritonitis (HP:0002586)3.28678020
36Autoimmune hemolytic anemia (HP:0001890)3.25297651
37Inflammation of the large intestine (HP:0002037)3.22391350
38Recurrent sinusitis (HP:0011108)3.22249077
39Bronchitis (HP:0012387)3.20810147
40Recurrent skin infections (HP:0001581)3.20707787
41Increased IgM level (HP:0003496)3.20702448
42Recurrent bacterial skin infections (HP:0005406)3.19131055
43Chronic sinusitis (HP:0011109)3.17166939
44Hypochromic microcytic anemia (HP:0004840)3.16752815
45Gastrointestinal inflammation (HP:0004386)3.14492539
46Abnormality of eosinophils (HP:0001879)3.11365277
47Amyloidosis (HP:0011034)3.08090465
48Autoimmune thrombocytopenia (HP:0001973)3.03738186
49Joint swelling (HP:0001386)3.02572323
50Mediastinal lymphadenopathy (HP:0100721)3.00637259
51Thyroiditis (HP:0100646)2.98772960
52Spontaneous hematomas (HP:0007420)2.96913442
53Leukocytosis (HP:0001974)2.96778095
54Abnormality of B cell number (HP:0010975)2.94296874
55B lymphocytopenia (HP:0010976)2.94296874
56Hemoptysis (HP:0002105)2.94066538
57Gastrointestinal stroma tumor (HP:0100723)2.89770362
58Urticaria (HP:0001025)2.86597142
59Hypergammaglobulinemia (HP:0010702)2.84644402
60Pulmonary infiltrates (HP:0002113)2.83789929
61IgA deficiency (HP:0002720)2.79365062
62Vertebral compression fractures (HP:0002953)2.76601957
63Loss of speech (HP:0002371)2.74320442
64Interstitial pulmonary disease (HP:0006530)2.74203524
65Emphysema (HP:0002097)2.73569220
66Colitis (HP:0002583)2.72622253
67Abnormality of the fingertips (HP:0001211)2.72188051
68Eosinophilia (HP:0001880)2.71713787
69Increased IgE level (HP:0003212)2.70511225
70Hypochromic anemia (HP:0001931)2.69271708
71Chronic obstructive pulmonary disease (HP:0006510)2.66293321
72Obstructive lung disease (HP:0006536)2.66293321
73Encephalitis (HP:0002383)2.64495746
74Premature rupture of membranes (HP:0001788)2.60983121
75Granulocytopenia (HP:0001913)2.59960712
76Episodic fever (HP:0001954)2.55814143
77Arterial thrombosis (HP:0004420)2.55167827
78Cellulitis (HP:0100658)2.50852435
79Abnormality of macrophages (HP:0004311)2.50437091
80Lymphoma (HP:0002665)2.45206780
81Protrusio acetabuli (HP:0003179)2.45044513
82Systemic lupus erythematosus (HP:0002725)2.43728452
83Keratoconjunctivitis sicca (HP:0001097)2.42640151
84Prolonged bleeding time (HP:0003010)2.42447100
85Papilloma (HP:0012740)2.42191361
86Verrucae (HP:0200043)2.42191361
87Epistaxis (HP:0000421)2.38679347
88Petechiae (HP:0000967)2.33188039
89Abnormality of the peritoneum (HP:0002585)2.25604078
90Hypoplasia of the thymus (HP:0000778)2.25304741
91Keratoconjunctivitis (HP:0001096)2.20959767
92Gastrointestinal infarctions (HP:0005244)2.17913452
93Chest pain (HP:0100749)2.15095971
94Segmental peripheral demyelination/remyelination (HP:0003481)2.14966507
95Recurrent gram-negative bacterial infections (HP:0005420)2.14421771
96Skin ulcer (HP:0200042)2.14016276
97Cheilitis (HP:0100825)2.12395399
98Gingivitis (HP:0000230)2.12109689
99Hemorrhage of the eye (HP:0011885)2.11411962
100Hepatosplenomegaly (HP:0001433)2.11170029
101Recurrent otitis media (HP:0000403)2.10287933
102Cervical subluxation (HP:0003308)2.10199974
103Basal cell carcinoma (HP:0002671)2.09083163
104Progressive neurologic deterioration (HP:0002344)2.07999908
105Vacuolated lymphocytes (HP:0001922)2.07568518
106Periodontitis (HP:0000704)2.05875115
107Polygenic inheritance (HP:0010982)2.04088259
108Abnormality of glycolipid metabolism (HP:0010969)2.03826191
109Abnormality of liposaccharide metabolism (HP:0010968)2.03826191
110Abnormality of glycosphingolipid metabolism (HP:0004343)2.03826191
111Sepsis (HP:0100806)2.02886404
112Restrictive lung disease (HP:0002091)2.01608462
113Pulmonary embolism (HP:0002204)2.00886933
114Dysostosis multiplex (HP:0000943)2.00134696
115Hypertriglyceridemia (HP:0002155)1.99838820
116Gingival bleeding (HP:0000225)1.99292869
117Supranuclear gaze palsy (HP:0000605)1.98210918
118Hypertensive crisis (HP:0100735)1.96660420
119Increased serum ferritin (HP:0003281)1.95341583
120Anorexia (HP:0002039)1.95217834
121Arthralgia (HP:0002829)1.94791709
122Abnormality of the pericardium (HP:0001697)1.93712952
123Hematochezia (HP:0002573)1.92356418
124Abnormality of the prostate (HP:0008775)1.91807522
125Increased connective tissue (HP:0009025)1.90588420
126Increased variability in muscle fiber diameter (HP:0003557)1.90530664
127Polycythemia (HP:0001901)1.89446947
128Increased cerebral lipofuscin (HP:0011813)1.87776007
129Bronchiectasis (HP:0002110)1.86455086
130Skin rash (HP:0000988)1.85964532
131Dilatation of the ascending aorta (HP:0005111)1.84396023
132Microcytic anemia (HP:0001935)1.83814655
133Joint hemorrhage (HP:0005261)1.83666363
134Growth hormone excess (HP:0000845)1.83646122
135Purpura (HP:0000979)1.83526921
136Malnutrition (HP:0004395)1.82749023
137Acne (HP:0001061)1.82517949
138Increased density of long bones (HP:0006392)1.82146316
139Gastrointestinal dysmotility (HP:0002579)1.81702016
140Centrally nucleated skeletal muscle fibers (HP:0003687)1.79497995
141Thin bony cortex (HP:0002753)1.74098773
142Abnormal hemoglobin (HP:0011902)1.72880474
143Long palpebral fissure (HP:0000637)1.72680365
144Premature loss of primary teeth (HP:0006323)1.71565616
145Glomerulopathy (HP:0100820)1.71226635
146Abnormality of alkaline phosphatase activity (HP:0004379)1.71146959
147Metaphyseal cupping (HP:0003021)1.70669408
148Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.70512966
149Abnormality of skeletal muscle fiber size (HP:0012084)1.69708126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.74197112
2TXK4.75792576
3JAK33.45197075
4TYK23.13214944
5FGFR43.05542346
6IKBKE2.99119515
7ZAP702.95021526
8ITK2.60877260
9STK102.52294892
10KIT2.36197158
11TBK12.33412683
12JAK12.32204024
13MAP3K142.15998153
14NLK2.15152336
15GRK62.02807374
16SMG12.02755210
17NME22.02562207
18PRPF4B1.98494123
19TEC1.90806025
20BLK1.87672099
21LCK1.87127725
22BTK1.81132112
23FGFR31.77448528
24MAP3K131.72692116
25TGFBR21.71547807
26KDR1.69100287
27IRAK41.66837214
28SYK1.64261553
29CSK1.56039411
30MAP3K121.48687666
31ARAF1.46913241
32HCK1.40852894
33CDK191.39112944
34IKBKB1.34720445
35LRRK21.29770825
36CSF1R1.28502118
37TAOK21.26287402
38MARK31.24930863
39ERN11.23407060
40ICK1.23084407
41MST41.22860226
42RIPK11.16509652
43FLT31.12222701
44SIK31.10047607
45PAK41.07362997
46MAP3K11.04915210
47LIMK11.02349015
48EPHA21.01859874
49FGR1.01741347
50TESK21.01004831
51PRKCH0.99502800
52LYN0.98635109
53RPS6KA40.95425784
54EPHA30.93193651
55KSR20.92151212
56FES0.91812412
57PRKCQ0.90416959
58LMTK20.88647498
59IRAK30.87006209
60JAK20.86540309
61PIM10.86335532
62MAP3K100.85831805
63SIK20.85096445
64DYRK1B0.83286461
65PKN20.82784981
66CHUK0.82343311
67MAP3K60.81351444
68EEF2K0.81063183
69EPHB10.80988640
70STK380.80868389
71MAP2K30.80801862
72CAMKK10.79310980
73CLK10.79227709
74CDC42BPA0.78652489
75PDPK10.77529197
76TGFBR10.72214837
77BMX0.67591382
78RPS6KA20.66388429
79EPHB20.64673146
80IRAK10.62558131
81MAP2K60.60123741
82PTK20.58144546
83TNK20.56615387
84TRIB30.55102212
85PRKD20.53595871
86MYLK0.52677545
87TTN0.52229530
88PAK10.51862379
89BCKDK0.51001237
90HIPK20.50703283
91RIPK40.49782006
92PRKD30.48829617
93BRAF0.47503127
94MAP3K80.47079962
95NEK90.46120974
96PTK2B0.45921269
97MAP3K70.45904917
98VRK20.43722703
99RPS6KC10.43610041
100RPS6KL10.43610041
101TAOK30.42067206
102MAP2K40.42014662
103PRKD10.40766683
104DYRK20.39894599
105PDK10.38629611
106MAPK110.38448022
107IRAK20.38220442
108SIK10.37819130
109IGF1R0.37797187
110ABL20.37044271
111FYN0.36544719
112MAP2K70.35855211
113TNIK0.34918975
114MATK0.34700228
115PIM20.33895899
116MAP2K20.33546743
117TAOK10.33535666
118NTRK10.33023054
119INSR0.32517696
120MARK20.32286347
121ADRBK20.31527570
122PDGFRB0.30994726
123CDK40.30872662
124PRKCD0.28989157
125MAP3K110.28053377
126MAPK120.27104943
127MAPK70.26890093
128PRKG20.26738739
129MAPK40.26361277
130ABL10.24171610
131MAPK30.23658759
132ILK0.23027737
133RPS6KA50.21487820
134PTK60.20611119
135MAP3K30.19469192
136TESK10.18941360
137MAPKAPK20.18370906
138EGFR0.17956695
139RPS6KA60.17693860
140ACVR1B0.17519593
141CDK60.17212294
142SRC0.14345674

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.40790339
2T cell receptor signaling pathway_Homo sapiens_hsa046603.10994292
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.03593884
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.85411736
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.84535663
6Measles_Homo sapiens_hsa051622.83194655
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.67246576
8Antigen processing and presentation_Homo sapiens_hsa046122.61855624
9Leishmaniasis_Homo sapiens_hsa051402.42303012
10Hematopoietic cell lineage_Homo sapiens_hsa046402.35914961
11Graft-versus-host disease_Homo sapiens_hsa053322.30397332
12B cell receptor signaling pathway_Homo sapiens_hsa046622.30365084
13Allograft rejection_Homo sapiens_hsa053302.26391717
14Osteoclast differentiation_Homo sapiens_hsa043802.17812746
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.04740188
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04580769
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97760957
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.91912083
19Herpes simplex infection_Homo sapiens_hsa051681.73259372
20Viral myocarditis_Homo sapiens_hsa054161.70802942
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57972056
22Toxoplasmosis_Homo sapiens_hsa051451.49201811
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.48952508
24Autoimmune thyroid disease_Homo sapiens_hsa053201.48082030
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42356889
26Chemokine signaling pathway_Homo sapiens_hsa040621.41078784
27Galactose metabolism_Homo sapiens_hsa000521.40784724
28Shigellosis_Homo sapiens_hsa051311.39859560
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39536768
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.37830409
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37064883
32Influenza A_Homo sapiens_hsa051641.36564568
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32788208
34Hepatitis B_Homo sapiens_hsa051611.32171319
35Malaria_Homo sapiens_hsa051441.32130337
36Acute myeloid leukemia_Homo sapiens_hsa052211.30156730
37Vibrio cholerae infection_Homo sapiens_hsa051101.29336936
38Ribosome_Homo sapiens_hsa030101.26199329
39TNF signaling pathway_Homo sapiens_hsa046681.20069081
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19882955
41Staphylococcus aureus infection_Homo sapiens_hsa051501.16442269
42Pentose phosphate pathway_Homo sapiens_hsa000301.14280228
43Tuberculosis_Homo sapiens_hsa051521.12366622
44Apoptosis_Homo sapiens_hsa042101.10340376
45Other glycan degradation_Homo sapiens_hsa005111.10196519
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09447835
47Legionellosis_Homo sapiens_hsa051341.06863854
48Platelet activation_Homo sapiens_hsa046111.05108642
49Pertussis_Homo sapiens_hsa051331.04323509
50Pancreatic cancer_Homo sapiens_hsa052121.02106881
51Hepatitis C_Homo sapiens_hsa051601.01610549
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99083948
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95452295
54HTLV-I infection_Homo sapiens_hsa051660.92972532
55Asthma_Homo sapiens_hsa053100.92661946
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92516459
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90770308
58Salmonella infection_Homo sapiens_hsa051320.88152487
59Fructose and mannose metabolism_Homo sapiens_hsa000510.86699403
60Rheumatoid arthritis_Homo sapiens_hsa053230.86205114
61Epstein-Barr virus infection_Homo sapiens_hsa051690.85726270
62Collecting duct acid secretion_Homo sapiens_hsa049660.80872768
63Prolactin signaling pathway_Homo sapiens_hsa049170.79149495
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78886439
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77830502
66Chronic myeloid leukemia_Homo sapiens_hsa052200.76556216
67Type I diabetes mellitus_Homo sapiens_hsa049400.75347505
68Endometrial cancer_Homo sapiens_hsa052130.73815798
69Amoebiasis_Homo sapiens_hsa051460.72700216
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.70280918
71VEGF signaling pathway_Homo sapiens_hsa043700.69505280
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.68159810
73Colorectal cancer_Homo sapiens_hsa052100.67841955
74Viral carcinogenesis_Homo sapiens_hsa052030.67099059
75Prion diseases_Homo sapiens_hsa050200.64547926
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63499998
77Bladder cancer_Homo sapiens_hsa052190.62839944
78Synaptic vesicle cycle_Homo sapiens_hsa047210.61368390
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.60791369
80Complement and coagulation cascades_Homo sapiens_hsa046100.60191278
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59219851
82Renal cell carcinoma_Homo sapiens_hsa052110.59094115
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58351192
84Lysosome_Homo sapiens_hsa041420.53378344
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53353993
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.52698762
87Notch signaling pathway_Homo sapiens_hsa043300.51734310
88Caffeine metabolism_Homo sapiens_hsa002320.50946763
89Insulin signaling pathway_Homo sapiens_hsa049100.50365427
90Sulfur relay system_Homo sapiens_hsa041220.49579009
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.49450430
92Choline metabolism in cancer_Homo sapiens_hsa052310.48281868
93Endocytosis_Homo sapiens_hsa041440.47021763
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46979536
95Small cell lung cancer_Homo sapiens_hsa052220.46642058
96African trypanosomiasis_Homo sapiens_hsa051430.43214738
97Base excision repair_Homo sapiens_hsa034100.42835051
98Thyroid cancer_Homo sapiens_hsa052160.40621609
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.39780241
100Non-small cell lung cancer_Homo sapiens_hsa052230.38992270
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.35041008
102Rap1 signaling pathway_Homo sapiens_hsa040150.33691375
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33144003
104FoxO signaling pathway_Homo sapiens_hsa040680.31518563
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30795216
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29407659
107* p53 signaling pathway_Homo sapiens_hsa041150.27536593
108Pathways in cancer_Homo sapiens_hsa052000.27042102
109Insulin resistance_Homo sapiens_hsa049310.25858114
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.25616332
111Non-homologous end-joining_Homo sapiens_hsa034500.25372571
112HIF-1 signaling pathway_Homo sapiens_hsa040660.24738375
113DNA replication_Homo sapiens_hsa030300.24032789
114Spliceosome_Homo sapiens_hsa030400.23702857
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22242063
116Focal adhesion_Homo sapiens_hsa045100.21842194
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21495401
118MAPK signaling pathway_Homo sapiens_hsa040100.21125040
119RNA degradation_Homo sapiens_hsa030180.20899648
120Adherens junction_Homo sapiens_hsa045200.20757665
121Inositol phosphate metabolism_Homo sapiens_hsa005620.20742436
122Proteoglycans in cancer_Homo sapiens_hsa052050.19436349
123Phagosome_Homo sapiens_hsa041450.19156148
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17983369
125N-Glycan biosynthesis_Homo sapiens_hsa005100.17065216

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