

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.39933402 |
| 2 | locomotory exploration behavior (GO:0035641) | 6.23022296 |
| 3 | synaptic vesicle maturation (GO:0016188) | 6.19567607 |
| 4 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 6.11141277 |
| 5 | vocalization behavior (GO:0071625) | 5.81762891 |
| 6 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.68795092 |
| 7 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.52159798 |
| 8 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.35993653 |
| 9 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 5.22720706 |
| 10 | synaptic vesicle exocytosis (GO:0016079) | 5.21506324 |
| 11 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 5.17588486 |
| 12 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 5.02107697 |
| 13 | regulation of synapse structural plasticity (GO:0051823) | 4.98754682 |
| 14 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.98015627 |
| 15 | glutamate secretion (GO:0014047) | 4.91652885 |
| 16 | protein localization to synapse (GO:0035418) | 4.88504429 |
| 17 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.85078538 |
| 18 | exploration behavior (GO:0035640) | 4.82136014 |
| 19 | dendritic spine morphogenesis (GO:0060997) | 4.58820819 |
| 20 | synaptic transmission, glutamatergic (GO:0035249) | 4.54854457 |
| 21 | regulation of synaptic vesicle transport (GO:1902803) | 4.46323207 |
| 22 | neuron cell-cell adhesion (GO:0007158) | 4.41034303 |
| 23 | glutamate receptor signaling pathway (GO:0007215) | 4.39130194 |
| 24 | cerebellar granule cell differentiation (GO:0021707) | 4.38600411 |
| 25 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.36119047 |
| 26 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.34352025 |
| 27 | neurotransmitter secretion (GO:0007269) | 4.33973216 |
| 28 | layer formation in cerebral cortex (GO:0021819) | 4.33136853 |
| 29 | L-amino acid import (GO:0043092) | 4.26753115 |
| 30 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.21874613 |
| 31 | long-term memory (GO:0007616) | 4.20791417 |
| 32 | regulation of dendritic spine morphogenesis (GO:0061001) | 4.19394531 |
| 33 | neuron-neuron synaptic transmission (GO:0007270) | 4.16530392 |
| 34 | neuronal action potential propagation (GO:0019227) | 4.14378434 |
| 35 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 4.12970882 |
| 36 | cell migration in hindbrain (GO:0021535) | 4.10521140 |
| 37 | positive regulation of membrane potential (GO:0045838) | 4.04980820 |
| 38 | axon ensheathment in central nervous system (GO:0032291) | 4.01862936 |
| 39 | central nervous system myelination (GO:0022010) | 4.01862936 |
| 40 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.98389641 |
| 41 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.94653779 |
| 42 | regulation of synaptic plasticity (GO:0048167) | 3.90911454 |
| 43 | presynaptic membrane assembly (GO:0097105) | 3.90395629 |
| 44 | regulation of postsynaptic membrane potential (GO:0060078) | 3.89443585 |
| 45 | positive regulation of synapse maturation (GO:0090129) | 3.89257268 |
| 46 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.86455362 |
| 47 | auditory behavior (GO:0031223) | 3.84109797 |
| 48 | neuromuscular process controlling balance (GO:0050885) | 3.80422410 |
| 49 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.79958398 |
| 50 | gamma-aminobutyric acid transport (GO:0015812) | 3.79746698 |
| 51 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.76128915 |
| 52 | presynaptic membrane organization (GO:0097090) | 3.75019090 |
| 53 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.74972990 |
| 54 | amino acid import (GO:0043090) | 3.70301389 |
| 55 | prepulse inhibition (GO:0060134) | 3.69500515 |
| 56 | potassium ion homeostasis (GO:0055075) | 3.67564785 |
| 57 | establishment of mitochondrion localization (GO:0051654) | 3.66969171 |
| 58 | neuron recognition (GO:0008038) | 3.65786651 |
| 59 | proline transport (GO:0015824) | 3.62765665 |
| 60 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.62431032 |
| 61 | transmission of nerve impulse (GO:0019226) | 3.62206260 |
| 62 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.60609830 |
| 63 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.58557634 |
| 64 | positive regulation of neurotransmitter transport (GO:0051590) | 3.57800698 |
| 65 | cellular potassium ion homeostasis (GO:0030007) | 3.56878915 |
| 66 | synaptic vesicle endocytosis (GO:0048488) | 3.53885408 |
| 67 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.52588606 |
| 68 | potassium ion import (GO:0010107) | 3.52490047 |
| 69 | response to auditory stimulus (GO:0010996) | 3.51836723 |
| 70 | behavioral defense response (GO:0002209) | 3.51139448 |
| 71 | behavioral fear response (GO:0001662) | 3.51139448 |
| 72 | dendritic spine organization (GO:0097061) | 3.50401656 |
| 73 | long-term synaptic potentiation (GO:0060291) | 3.49463523 |
| 74 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.49452493 |
| 75 | activation of protein kinase A activity (GO:0034199) | 3.48089101 |
| 76 | neuronal ion channel clustering (GO:0045161) | 3.47986426 |
| 77 | regulation of dendritic spine development (GO:0060998) | 3.44660343 |
| 78 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.44265370 |
| 79 | positive regulation of dendritic spine development (GO:0060999) | 3.43982765 |
| 80 | neurotransmitter transport (GO:0006836) | 3.43844538 |
| 81 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.43590679 |
| 82 | axonal fasciculation (GO:0007413) | 3.42178094 |
| 83 | neuromuscular synaptic transmission (GO:0007274) | 3.40522302 |
| 84 | regulation of neurotransmitter secretion (GO:0046928) | 3.37826989 |
| 85 | dendrite morphogenesis (GO:0048813) | 3.37642795 |
| 86 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.36654007 |
| 87 | regulation of vesicle fusion (GO:0031338) | 3.35797598 |
| 88 | learning (GO:0007612) | 3.34653154 |
| 89 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.30392084 |
| 90 | membrane depolarization (GO:0051899) | 3.29552444 |
| 91 | regulation of neurotransmitter levels (GO:0001505) | 3.25632144 |
| 92 | sodium ion export (GO:0071436) | 3.22629906 |
| 93 | regulation of female receptivity (GO:0045924) | 3.22557113 |
| 94 | fear response (GO:0042596) | 3.21363039 |
| 95 | postsynaptic membrane organization (GO:0001941) | 3.20901480 |
| 96 | regulation of neurotransmitter transport (GO:0051588) | 3.18960170 |
| 97 | positive regulation of synaptic transmission (GO:0050806) | 3.17092348 |
| 98 | membrane hyperpolarization (GO:0060081) | 3.15495661 |
| 99 | mitochondrion transport along microtubule (GO:0047497) | 3.15002293 |
| 100 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.15002293 |
| 101 | membrane depolarization during action potential (GO:0086010) | 3.14826213 |
| 102 | visual learning (GO:0008542) | 3.13654296 |
| 103 | glycine transport (GO:0015816) | 3.11568091 |
| 104 | regulation of synaptic transmission (GO:0050804) | 3.11195444 |
| 105 | neuromuscular process (GO:0050905) | 3.10973352 |
| 106 | synaptic transmission (GO:0007268) | 3.10155096 |
| 107 | dopamine receptor signaling pathway (GO:0007212) | 3.09734603 |
| 108 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.09592203 |
| 109 | response to histamine (GO:0034776) | 3.09376507 |
| 110 | vesicle transport along microtubule (GO:0047496) | 3.08640139 |
| 111 | social behavior (GO:0035176) | 3.07771089 |
| 112 | intraspecies interaction between organisms (GO:0051703) | 3.07771089 |
| 113 | cell communication by electrical coupling (GO:0010644) | 3.07076120 |
| 114 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.06098410 |
| 115 | striatum development (GO:0021756) | 3.06025656 |
| 116 | adult walking behavior (GO:0007628) | 3.05723599 |
| 117 | regulation of respiratory system process (GO:0044065) | 3.05041141 |
| 118 | regulation of glutamate secretion (GO:0014048) | 3.04917015 |
| 119 | neuromuscular process controlling posture (GO:0050884) | 3.04190833 |
| 120 | acidic amino acid transport (GO:0015800) | 3.04174450 |
| 121 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.03985523 |
| 122 | chemosensory behavior (GO:0007635) | 3.02830413 |
| 123 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.02475564 |
| 124 | regulation of synapse maturation (GO:0090128) | 3.02315159 |
| 125 | innervation (GO:0060384) | 3.00712842 |
| 126 | regulation of ARF protein signal transduction (GO:0032012) | 2.98612051 |
| 127 | cellular sodium ion homeostasis (GO:0006883) | 2.95315559 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.45601682 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.46249174 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.13685840 |
| 4 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 3.11104840 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.09763798 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.01326382 |
| 7 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.86925114 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.76028259 |
| 9 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.76028259 |
| 10 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.75819584 |
| 11 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.69846437 |
| 12 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.63469432 |
| 13 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.54953455 |
| 14 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.54097076 |
| 15 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.52412884 |
| 16 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.47286839 |
| 17 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.45011962 |
| 18 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.42015228 |
| 19 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.34490672 |
| 20 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.32780515 |
| 21 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.32176867 |
| 22 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.24097022 |
| 23 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.23764915 |
| 24 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.22994615 |
| 25 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.20975736 |
| 26 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.18894978 |
| 27 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.08564001 |
| 28 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.00665526 |
| 29 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.90091455 |
| 30 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.84127137 |
| 31 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.79043244 |
| 32 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.69710746 |
| 33 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.62738159 |
| 34 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.56946334 |
| 35 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.46877802 |
| 36 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.46720654 |
| 37 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.45102083 |
| 38 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.41417746 |
| 39 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.39817883 |
| 40 | * RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.37404266 |
| 41 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.34882476 |
| 42 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.29843388 |
| 43 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.29243781 |
| 44 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.28988878 |
| 45 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.28213864 |
| 46 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.25211633 |
| 47 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.25200643 |
| 48 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.25054148 |
| 49 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.24164997 |
| 50 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.24078724 |
| 51 | AR_19668381_ChIP-Seq_PC3_Human | 1.24031971 |
| 52 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.23337657 |
| 53 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.20117527 |
| 54 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.19815811 |
| 55 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.18764372 |
| 56 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.15426453 |
| 57 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.15355138 |
| 58 | STAT3_23295773_ChIP-Seq_U87_Human | 1.14977340 |
| 59 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.14863438 |
| 60 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.14416883 |
| 61 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.14363060 |
| 62 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.13840523 |
| 63 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.13558081 |
| 64 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.12891922 |
| 65 | P300_19829295_ChIP-Seq_ESCs_Human | 1.11109520 |
| 66 | AR_25329375_ChIP-Seq_VCAP_Human | 1.10898457 |
| 67 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.07524159 |
| 68 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.07474999 |
| 69 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.06658196 |
| 70 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05967610 |
| 71 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.03674552 |
| 72 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.02429903 |
| 73 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.02390103 |
| 74 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.01379580 |
| 75 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00488130 |
| 76 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.99973215 |
| 77 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.99970922 |
| 78 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.99891408 |
| 79 | TCF4_23295773_ChIP-Seq_U87_Human | 0.99536040 |
| 80 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.99042606 |
| 81 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.98904707 |
| 82 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.98364554 |
| 83 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.97786184 |
| 84 | * ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.97170266 |
| 85 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.96934707 |
| 86 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.96111236 |
| 87 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.94211897 |
| 88 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.93626930 |
| 89 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.93418076 |
| 90 | * AHR_22903824_ChIP-Seq_MCF-7_Human | 0.92662301 |
| 91 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.91593075 |
| 92 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.91405417 |
| 93 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.91267291 |
| 94 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.90904354 |
| 95 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.90167077 |
| 96 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.90106051 |
| 97 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.89794368 |
| 98 | RXR_22108803_ChIP-Seq_LS180_Human | 0.88969680 |
| 99 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.88807549 |
| 100 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.88731850 |
| 101 | * SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.88232057 |
| 102 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.87870241 |
| 103 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.87387360 |
| 104 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.86989503 |
| 105 | TP53_16413492_ChIP-PET_HCT116_Human | 0.85951442 |
| 106 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.85375953 |
| 107 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.85305729 |
| 108 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.84451383 |
| 109 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.82825975 |
| 110 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.82311840 |
| 111 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.81314177 |
| 112 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.81314177 |
| 113 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.80755529 |
| 114 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.78806800 |
| 115 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.77273377 |
| 116 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.77093876 |
| 117 | * PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.76581560 |
| 118 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.74518819 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 7.45513903 |
| 2 | MP0003880_abnormal_central_pattern | 4.81786026 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.38504203 |
| 4 | MP0002822_catalepsy | 4.22095104 |
| 5 | MP0004270_analgesia | 3.78506560 |
| 6 | MP0002063_abnormal_learning/memory/cond | 3.63129308 |
| 7 | MP0009745_abnormal_behavioral_response | 3.60116903 |
| 8 | MP0002064_seizures | 3.17225843 |
| 9 | MP0005423_abnormal_somatic_nervous | 2.93723985 |
| 10 | MP0002572_abnormal_emotion/affect_behav | 2.90747496 |
| 11 | MP0001968_abnormal_touch/_nociception | 2.87297950 |
| 12 | MP0009046_muscle_twitch | 2.76256344 |
| 13 | MP0001486_abnormal_startle_reflex | 2.59331543 |
| 14 | MP0002272_abnormal_nervous_system | 2.48412327 |
| 15 | MP0002734_abnormal_mechanical_nocicepti | 2.47100039 |
| 16 | MP0001501_abnormal_sleep_pattern | 2.25799839 |
| 17 | MP0002736_abnormal_nociception_after | 2.12539401 |
| 18 | MP0001440_abnormal_grooming_behavior | 2.04094626 |
| 19 | MP0002735_abnormal_chemical_nociception | 2.03550360 |
| 20 | MP0002733_abnormal_thermal_nociception | 1.95252912 |
| 21 | MP0009780_abnormal_chondrocyte_physiolo | 1.93075665 |
| 22 | MP0001970_abnormal_pain_threshold | 1.90586958 |
| 23 | MP0004811_abnormal_neuron_physiology | 1.87292304 |
| 24 | MP0000778_abnormal_nervous_system | 1.84494735 |
| 25 | MP0002557_abnormal_social/conspecific_i | 1.79668108 |
| 26 | MP0002909_abnormal_adrenal_gland | 1.79525792 |
| 27 | MP0004858_abnormal_nervous_system | 1.77273148 |
| 28 | MP0008569_lethality_at_weaning | 1.76342584 |
| 29 | MP0005646_abnormal_pituitary_gland | 1.74126759 |
| 30 | MP0004924_abnormal_behavior | 1.74101406 |
| 31 | MP0005386_behavior/neurological_phenoty | 1.74101406 |
| 32 | MP0002067_abnormal_sensory_capabilities | 1.74029676 |
| 33 | MP0002184_abnormal_innervation | 1.70572746 |
| 34 | MP0003329_amyloid_beta_deposits | 1.64306988 |
| 35 | MP0003879_abnormal_hair_cell | 1.61384629 |
| 36 | MP0001529_abnormal_vocalization | 1.55228283 |
| 37 | MP0003787_abnormal_imprinting | 1.52810870 |
| 38 | MP0004885_abnormal_endolymph | 1.52688264 |
| 39 | MP0000955_abnormal_spinal_cord | 1.51108601 |
| 40 | MP0005645_abnormal_hypothalamus_physiol | 1.44831906 |
| 41 | MP0001984_abnormal_olfaction | 1.42569472 |
| 42 | MP0002066_abnormal_motor_capabilities/c | 1.40438538 |
| 43 | MP0002882_abnormal_neuron_morphology | 1.38704581 |
| 44 | MP0006276_abnormal_autonomic_nervous | 1.35583833 |
| 45 | MP0003633_abnormal_nervous_system | 1.33909061 |
| 46 | MP0003123_paternal_imprinting | 1.32425835 |
| 47 | MP0000569_abnormal_digit_pigmentation | 1.21179274 |
| 48 | MP0001188_hyperpigmentation | 1.18549614 |
| 49 | MP0001905_abnormal_dopamine_level | 1.16778405 |
| 50 | MP0001502_abnormal_circadian_rhythm | 1.16490909 |
| 51 | MP0002152_abnormal_brain_morphology | 1.13783544 |
| 52 | MP0003075_altered_response_to | 1.12070736 |
| 53 | MP0004147_increased_porphyrin_level | 1.10290611 |
| 54 | MP0003631_nervous_system_phenotype | 1.09615314 |
| 55 | MP0008872_abnormal_physiological_respon | 1.08317137 |
| 56 | MP0008961_abnormal_basal_metabolism | 1.08263604 |
| 57 | MP0004142_abnormal_muscle_tone | 1.07488817 |
| 58 | MP0001177_atelectasis | 1.05150061 |
| 59 | MP0003122_maternal_imprinting | 1.05136344 |
| 60 | MP0003121_genomic_imprinting | 1.01964677 |
| 61 | MP0002653_abnormal_ependyma_morphology | 1.00592064 |
| 62 | MP0002069_abnormal_eating/drinking_beha | 1.00023902 |
| 63 | MP0008874_decreased_physiological_sensi | 0.96568601 |
| 64 | MP0005409_darkened_coat_color | 0.93993306 |
| 65 | MP0003283_abnormal_digestive_organ | 0.92956648 |
| 66 | MP0001348_abnormal_lacrimal_gland | 0.91547867 |
| 67 | MP0008877_abnormal_DNA_methylation | 0.88263253 |
| 68 | MP0004085_abnormal_heartbeat | 0.87773943 |
| 69 | MP0000751_myopathy | 0.86101525 |
| 70 | MP0005394_taste/olfaction_phenotype | 0.85836982 |
| 71 | MP0005499_abnormal_olfactory_system | 0.85836982 |
| 72 | MP0010386_abnormal_urinary_bladder | 0.85373921 |
| 73 | MP0002229_neurodegeneration | 0.82856056 |
| 74 | MP0001986_abnormal_taste_sensitivity | 0.80276164 |
| 75 | MP0005535_abnormal_body_temperature | 0.79863953 |
| 76 | MP0005167_abnormal_blood-brain_barrier | 0.78095503 |
| 77 | MP0000631_abnormal_neuroendocrine_gland | 0.77224711 |
| 78 | MP0003690_abnormal_glial_cell | 0.75703771 |
| 79 | MP0003137_abnormal_impulse_conducting | 0.72779236 |
| 80 | MP0003634_abnormal_glial_cell | 0.72423921 |
| 81 | MP0001346_abnormal_lacrimal_gland | 0.69519581 |
| 82 | MP0003632_abnormal_nervous_system | 0.69314161 |
| 83 | MP0004145_abnormal_muscle_electrophysio | 0.68722444 |
| 84 | MP0001963_abnormal_hearing_physiology | 0.67830738 |
| 85 | MP0000920_abnormal_myelination | 0.66507391 |
| 86 | MP0000604_amyloidosis | 0.66497432 |
| 87 | MP0004130_abnormal_muscle_cell | 0.66293493 |
| 88 | MP0010234_abnormal_vibrissa_follicle | 0.65976457 |
| 89 | MP0000026_abnormal_inner_ear | 0.65882136 |
| 90 | MP0004742_abnormal_vestibular_system | 0.65549107 |
| 91 | MP0003172_abnormal_lysosome_physiology | 0.64466848 |
| 92 | MP0004510_myositis | 0.64463805 |
| 93 | MP0005551_abnormal_eye_electrophysiolog | 0.64370919 |
| 94 | MP0002752_abnormal_somatic_nervous | 0.64287341 |
| 95 | MP0000013_abnormal_adipose_tissue | 0.63000545 |
| 96 | MP0001664_abnormal_digestion | 0.62862960 |
| 97 | MP0003861_abnormal_nervous_system | 0.62638884 |
| 98 | MP0002638_abnormal_pupillary_reflex | 0.61720459 |
| 99 | MP0003938_abnormal_ear_development | 0.61620893 |
| 100 | MP0002090_abnormal_vision | 0.59811439 |
| 101 | MP0001299_abnormal_eye_distance/ | 0.59484037 |
| 102 | MP0001485_abnormal_pinna_reflex | 0.58839008 |
| 103 | MP0006292_abnormal_olfactory_placode | 0.56135468 |
| 104 | MP0010769_abnormal_survival | 0.54864889 |
| 105 | MP0004043_abnormal_pH_regulation | 0.54837949 |
| 106 | MP0002234_abnormal_pharynx_morphology | 0.54644831 |
| 107 | MP0010770_preweaning_lethality | 0.52312713 |
| 108 | MP0002082_postnatal_lethality | 0.52312713 |
| 109 | MP0001943_abnormal_respiration | 0.52108855 |
| 110 | MP0010768_mortality/aging | 0.51503304 |
| 111 | MP0000566_synostosis | 0.50922364 |
| 112 | MP0004484_altered_response_of | 0.49988586 |
| 113 | MP0004233_abnormal_muscle_weight | 0.49437233 |
| 114 | MP0003956_abnormal_body_size | 0.49253467 |
| 115 | MP0002081_perinatal_lethality | 0.47541318 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 8.04316469 |
| 2 | Focal motor seizures (HP:0011153) | 7.99468320 |
| 3 | Focal seizures (HP:0007359) | 5.91403554 |
| 4 | Visual hallucinations (HP:0002367) | 4.96248736 |
| 5 | Epileptic encephalopathy (HP:0200134) | 4.67434651 |
| 6 | Progressive cerebellar ataxia (HP:0002073) | 4.09066116 |
| 7 | Febrile seizures (HP:0002373) | 4.01707312 |
| 8 | Poor eye contact (HP:0000817) | 3.95334284 |
| 9 | Broad-based gait (HP:0002136) | 3.87306154 |
| 10 | Absence seizures (HP:0002121) | 3.81578686 |
| 11 | Generalized tonic-clonic seizures (HP:0002069) | 3.80073178 |
| 12 | Action tremor (HP:0002345) | 3.75417984 |
| 13 | Atonic seizures (HP:0010819) | 3.75351629 |
| 14 | Ankle clonus (HP:0011448) | 3.69970987 |
| 15 | Supranuclear gaze palsy (HP:0000605) | 3.68509496 |
| 16 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.64173820 |
| 17 | Abnormal social behavior (HP:0012433) | 3.54212993 |
| 18 | Impaired social interactions (HP:0000735) | 3.54212993 |
| 19 | Dialeptic seizures (HP:0011146) | 3.54023994 |
| 20 | Peripheral hypomyelination (HP:0007182) | 3.47194688 |
| 21 | Papilledema (HP:0001085) | 3.45794168 |
| 22 | Depression (HP:0000716) | 3.40195602 |
| 23 | Gaze-evoked nystagmus (HP:0000640) | 3.24503633 |
| 24 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.23813029 |
| 25 | Torticollis (HP:0000473) | 3.19009925 |
| 26 | Postural instability (HP:0002172) | 3.15418685 |
| 27 | Dysdiadochokinesis (HP:0002075) | 3.13577570 |
| 28 | Mutism (HP:0002300) | 3.12241662 |
| 29 | Anxiety (HP:0000739) | 3.11365249 |
| 30 | Abnormality of the lower motor neuron (HP:0002366) | 3.11319660 |
| 31 | Dysmetria (HP:0001310) | 3.10722218 |
| 32 | Hyperventilation (HP:0002883) | 3.10210362 |
| 33 | Amblyopia (HP:0000646) | 3.01557706 |
| 34 | Abnormal eating behavior (HP:0100738) | 2.98296557 |
| 35 | Focal dystonia (HP:0004373) | 2.96517298 |
| 36 | Urinary urgency (HP:0000012) | 2.89146727 |
| 37 | Stereotypic behavior (HP:0000733) | 2.89068558 |
| 38 | Genetic anticipation (HP:0003743) | 2.88512531 |
| 39 | Drooling (HP:0002307) | 2.82180830 |
| 40 | Excessive salivation (HP:0003781) | 2.82180830 |
| 41 | Akinesia (HP:0002304) | 2.81739656 |
| 42 | Truncal ataxia (HP:0002078) | 2.80689940 |
| 43 | Cerebral hypomyelination (HP:0006808) | 2.77430712 |
| 44 | Annular pancreas (HP:0001734) | 2.77387368 |
| 45 | Impaired smooth pursuit (HP:0007772) | 2.70456866 |
| 46 | Spastic gait (HP:0002064) | 2.66986571 |
| 47 | Delusions (HP:0000746) | 2.65121180 |
| 48 | Craniofacial dystonia (HP:0012179) | 2.64569674 |
| 49 | Hemiparesis (HP:0001269) | 2.61537639 |
| 50 | Bradykinesia (HP:0002067) | 2.55938526 |
| 51 | Pointed chin (HP:0000307) | 2.55372157 |
| 52 | Spastic tetraparesis (HP:0001285) | 2.51569439 |
| 53 | Hemiplegia (HP:0002301) | 2.50147475 |
| 54 | Intention tremor (HP:0002080) | 2.48947820 |
| 55 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.45577262 |
| 56 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.45577262 |
| 57 | Impaired vibratory sensation (HP:0002495) | 2.42192991 |
| 58 | Cerebral inclusion bodies (HP:0100314) | 2.40953166 |
| 59 | Megalencephaly (HP:0001355) | 2.40641269 |
| 60 | Epileptiform EEG discharges (HP:0011182) | 2.40343127 |
| 61 | Neurofibrillary tangles (HP:0002185) | 2.37785462 |
| 62 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.35249676 |
| 63 | Scanning speech (HP:0002168) | 2.34808093 |
| 64 | Progressive inability to walk (HP:0002505) | 2.34457961 |
| 65 | Diplopia (HP:0000651) | 2.34045124 |
| 66 | Abnormality of binocular vision (HP:0011514) | 2.34045124 |
| 67 | Ankyloglossia (HP:0010296) | 2.33439411 |
| 68 | Obstructive sleep apnea (HP:0002870) | 2.29021619 |
| 69 | Absent speech (HP:0001344) | 2.26441535 |
| 70 | Ventricular fibrillation (HP:0001663) | 2.26396553 |
| 71 | Lower limb muscle weakness (HP:0007340) | 2.25861236 |
| 72 | EEG with generalized epileptiform discharges (HP:0011198) | 2.24370352 |
| 73 | Insomnia (HP:0100785) | 2.22733522 |
| 74 | Lower limb amyotrophy (HP:0007210) | 2.22329783 |
| 75 | Limb dystonia (HP:0002451) | 2.16989041 |
| 76 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.16932676 |
| 77 | Status epilepticus (HP:0002133) | 2.15262719 |
| 78 | Tetraplegia (HP:0002445) | 2.14695826 |
| 79 | Hypsarrhythmia (HP:0002521) | 2.13718801 |
| 80 | Polyphagia (HP:0002591) | 2.13709192 |
| 81 | Diminished motivation (HP:0000745) | 2.11930950 |
| 82 | Dysmetric saccades (HP:0000641) | 2.11717728 |
| 83 | Abnormal EKG (HP:0003115) | 2.11125673 |
| 84 | Fetal akinesia sequence (HP:0001989) | 2.08335702 |
| 85 | Insidious onset (HP:0003587) | 2.07701003 |
| 86 | Termporal pattern (HP:0011008) | 2.07701003 |
| 87 | Abnormality of the corticospinal tract (HP:0002492) | 2.07586020 |
| 88 | Incomplete penetrance (HP:0003829) | 2.06977781 |
| 89 | Amyotrophic lateral sclerosis (HP:0007354) | 2.02939211 |
| 90 | Increased circulating renin level (HP:0000848) | 2.02755498 |
| 91 | Agitation (HP:0000713) | 2.02071421 |
| 92 | Clonus (HP:0002169) | 2.00785741 |
| 93 | Gait imbalance (HP:0002141) | 1.99459080 |
| 94 | Generalized myoclonic seizures (HP:0002123) | 1.95634400 |
| 95 | Resting tremor (HP:0002322) | 1.95588627 |
| 96 | Spastic tetraplegia (HP:0002510) | 1.94916483 |
| 97 | Hypoplasia of the corpus callosum (HP:0002079) | 1.94646015 |
| 98 | Inappropriate behavior (HP:0000719) | 1.93436010 |
| 99 | Gait ataxia (HP:0002066) | 1.90398846 |
| 100 | Inability to walk (HP:0002540) | 1.90378620 |
| 101 | Neuronal loss in central nervous system (HP:0002529) | 1.88395589 |
| 102 | Protruding tongue (HP:0010808) | 1.86639229 |
| 103 | Abnormality of salivation (HP:0100755) | 1.85983025 |
| 104 | Lower limb asymmetry (HP:0100559) | 1.85069023 |
| 105 | Sleep apnea (HP:0010535) | 1.83668310 |
| 106 | Bundle branch block (HP:0011710) | 1.82404656 |
| 107 | Split foot (HP:0001839) | 1.81895206 |
| 108 | CNS hypomyelination (HP:0003429) | 1.81528045 |
| 109 | Failure to thrive in infancy (HP:0001531) | 1.81359931 |
| 110 | Apathy (HP:0000741) | 1.80760127 |
| 111 | Blue irides (HP:0000635) | 1.80072975 |
| 112 | Rigidity (HP:0002063) | 1.78785020 |
| 113 | Abnormality of the labia minora (HP:0012880) | 1.74850810 |
| 114 | Aqueductal stenosis (HP:0002410) | 1.73645237 |
| 115 | Specific learning disability (HP:0001328) | 1.73333170 |
| 116 | Autism (HP:0000717) | 1.72841283 |
| 117 | Abnormality of the periventricular white matter (HP:0002518) | 1.72186838 |
| 118 | Truncus arteriosus (HP:0001660) | 1.71802898 |
| 119 | Aplasia involving bones of the extremities (HP:0009825) | 1.70890620 |
| 120 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.70890620 |
| 121 | Aplasia of the phalanges of the hand (HP:0009802) | 1.70890620 |
| 122 | Psychosis (HP:0000709) | 1.70518190 |
| 123 | Choreoathetosis (HP:0001266) | 1.67534591 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 5.61313419 |
| 2 | NTRK3 | 4.80438937 |
| 3 | MAP3K9 | 3.95552042 |
| 4 | MARK1 | 3.22710661 |
| 5 | DAPK2 | 2.74143320 |
| 6 | MAP3K4 | 2.68418519 |
| 7 | MINK1 | 2.56764471 |
| 8 | PRKD3 | 2.33945671 |
| 9 | KSR2 | 2.27649940 |
| 10 | PAK6 | 2.19758277 |
| 11 | NTRK2 | 2.14333146 |
| 12 | MAP2K7 | 2.11751801 |
| 13 | RIPK4 | 1.98852413 |
| 14 | KSR1 | 1.91796758 |
| 15 | CAMKK1 | 1.90030111 |
| 16 | DAPK1 | 1.82081374 |
| 17 | MAP2K4 | 1.65673402 |
| 18 | SIK2 | 1.63203638 |
| 19 | CDK5 | 1.62197367 |
| 20 | NTRK1 | 1.58730157 |
| 21 | TNIK | 1.48248837 |
| 22 | PRPF4B | 1.46526401 |
| 23 | MAP3K12 | 1.43419111 |
| 24 | TYRO3 | 1.41958469 |
| 25 | FES | 1.36386633 |
| 26 | STK38 | 1.32913890 |
| 27 | TAOK1 | 1.28497174 |
| 28 | MAPK13 | 1.25858601 |
| 29 | ARAF | 1.23363705 |
| 30 | MAP3K13 | 1.22867420 |
| 31 | PRKCG | 1.19957437 |
| 32 | CASK | 1.19938531 |
| 33 | MAP3K2 | 1.17759099 |
| 34 | PKN1 | 1.15740813 |
| 35 | PLK2 | 1.15505707 |
| 36 | CDK19 | 1.09424475 |
| 37 | UHMK1 | 1.03139400 |
| 38 | GRK5 | 1.01859566 |
| 39 | PNCK | 0.96188416 |
| 40 | CAMK1 | 0.95438034 |
| 41 | SGK223 | 0.94672655 |
| 42 | SGK494 | 0.94672655 |
| 43 | CAMK2A | 0.93205562 |
| 44 | RAF1 | 0.93154158 |
| 45 | MARK2 | 0.91296301 |
| 46 | CDK18 | 0.91270503 |
| 47 | DYRK2 | 0.89447613 |
| 48 | STK11 | 0.89272506 |
| 49 | CDK15 | 0.88254820 |
| 50 | CAMK2B | 0.86485826 |
| 51 | PINK1 | 0.84215544 |
| 52 | SGK2 | 0.83805191 |
| 53 | MAPK12 | 0.83674688 |
| 54 | EPHB2 | 0.82973427 |
| 55 | CDK14 | 0.82512553 |
| 56 | PTK2B | 0.82393720 |
| 57 | PRKCH | 0.81528379 |
| 58 | PHKG1 | 0.80921800 |
| 59 | PHKG2 | 0.80921800 |
| 60 | LATS2 | 0.80124001 |
| 61 | ALK | 0.79584168 |
| 62 | SGK1 | 0.78263916 |
| 63 | SGK3 | 0.77730960 |
| 64 | CDK11A | 0.76645133 |
| 65 | RET | 0.73679312 |
| 66 | CAMKK2 | 0.73463589 |
| 67 | BMPR2 | 0.72841495 |
| 68 | PDK1 | 0.66029602 |
| 69 | MAP3K11 | 0.65947616 |
| 70 | DYRK1A | 0.65581537 |
| 71 | PDPK1 | 0.63448079 |
| 72 | CAMK1D | 0.61133706 |
| 73 | PRKCZ | 0.60223695 |
| 74 | CSNK1G2 | 0.59643243 |
| 75 | PAK3 | 0.58445022 |
| 76 | MAP3K1 | 0.53895090 |
| 77 | LMTK2 | 0.52184112 |
| 78 | RPS6KA3 | 0.51815406 |
| 79 | CAMK4 | 0.50977758 |
| 80 | DMPK | 0.50453315 |
| 81 | OXSR1 | 0.50140118 |
| 82 | MAP3K7 | 0.48887328 |
| 83 | WNK3 | 0.48579291 |
| 84 | CDC42BPA | 0.48156655 |
| 85 | TNK2 | 0.48112885 |
| 86 | FYN | 0.47739051 |
| 87 | MAPK10 | 0.46514556 |
| 88 | SIK3 | 0.46014888 |
| 89 | AKT3 | 0.44775709 |
| 90 | CCNB1 | 0.44330794 |
| 91 | FGR | 0.42757860 |
| 92 | BRSK1 | 0.42299565 |
| 93 | NEK6 | 0.41941539 |
| 94 | PRKCE | 0.40734951 |
| 95 | NEK1 | 0.40562623 |
| 96 | MAP2K1 | 0.38470417 |
| 97 | DAPK3 | 0.38191095 |
| 98 | CAMK1G | 0.37944737 |
| 99 | WNK1 | 0.37873909 |
| 100 | MAPK8 | 0.36718433 |
| 101 | BRAF | 0.36367367 |
| 102 | NME1 | 0.34782959 |
| 103 | BCR | 0.34522812 |
| 104 | CSNK1D | 0.34287420 |
| 105 | PRKG1 | 0.34105036 |
| 106 | FGFR2 | 0.33842618 |
| 107 | PRKCA | 0.33232249 |
| 108 | CAMK2G | 0.33223362 |
| 109 | ERBB2 | 0.33168833 |
| 110 | RIPK1 | 0.33095269 |
| 111 | PRKACA | 0.33082618 |
| 112 | CAMK2D | 0.33046616 |
| 113 | PRKCB | 0.32888021 |
| 114 | RPS6KA2 | 0.32887473 |
| 115 | GSK3B | 0.32470100 |
| 116 | CSNK1E | 0.31585757 |
| 117 | PRKD2 | 0.30881289 |
| 118 | CSNK1G3 | 0.29490427 |
| 119 | ROCK2 | 0.28081213 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.63309468 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.05313552 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 3.03185516 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.82626998 |
| 5 | Long-term potentiation_Homo sapiens_hsa04720 | 2.80375760 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.69666661 |
| 7 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.65521924 |
| 8 | GABAergic synapse_Homo sapiens_hsa04727 | 2.65253959 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.58291242 |
| 10 | Morphine addiction_Homo sapiens_hsa05032 | 2.55625014 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.28889517 |
| 12 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.19787218 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 2.18253711 |
| 14 | Cholinergic synapse_Homo sapiens_hsa04725 | 2.03817461 |
| 15 | Insulin secretion_Homo sapiens_hsa04911 | 1.97380544 |
| 16 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.91841707 |
| 17 | Cocaine addiction_Homo sapiens_hsa05030 | 1.91597357 |
| 18 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.89052255 |
| 19 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.73144127 |
| 20 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.71705584 |
| 21 | Renin secretion_Homo sapiens_hsa04924 | 1.69667408 |
| 22 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.66070168 |
| 23 | Long-term depression_Homo sapiens_hsa04730 | 1.65864874 |
| 24 | Taste transduction_Homo sapiens_hsa04742 | 1.61566569 |
| 25 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.60226027 |
| 26 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.51493868 |
| 27 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.43506340 |
| 28 | Gap junction_Homo sapiens_hsa04540 | 1.42205126 |
| 29 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.34750476 |
| 30 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.34748638 |
| 31 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.31867867 |
| 32 | Glioma_Homo sapiens_hsa05214 | 1.26500443 |
| 33 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.23217074 |
| 34 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.22407567 |
| 35 | Axon guidance_Homo sapiens_hsa04360 | 1.21975142 |
| 36 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.13239811 |
| 37 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.12048182 |
| 38 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.11475021 |
| 39 | Melanogenesis_Homo sapiens_hsa04916 | 1.05582378 |
| 40 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.03603857 |
| 41 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.02135147 |
| 42 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.00454947 |
| 43 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.95747136 |
| 44 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.95724712 |
| 45 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.94198809 |
| 46 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.93972894 |
| 47 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.93272820 |
| 48 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.91139753 |
| 49 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.85640107 |
| 50 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.82830218 |
| 51 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.82617954 |
| 52 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.82144845 |
| 53 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.80188613 |
| 54 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.79683810 |
| 55 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.79191109 |
| 56 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.74276908 |
| 57 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.71781080 |
| 58 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.71779271 |
| 59 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.71437597 |
| 60 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.71059365 |
| 61 | Phototransduction_Homo sapiens_hsa04744 | 0.68221143 |
| 62 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.66775187 |
| 63 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.65919828 |
| 64 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.65664777 |
| 65 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.62905399 |
| 66 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.61843057 |
| 67 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.61186006 |
| 68 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.60916597 |
| 69 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.59283270 |
| 70 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.59104909 |
| 71 | Alcoholism_Homo sapiens_hsa05034 | 0.57837708 |
| 72 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.57020783 |
| 73 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.55288629 |
| 74 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.54648578 |
| 75 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.52416433 |
| 76 | Endometrial cancer_Homo sapiens_hsa05213 | 0.52247537 |
| 77 | Endocytosis_Homo sapiens_hsa04144 | 0.52116174 |
| 78 | Bile secretion_Homo sapiens_hsa04976 | 0.49017151 |
| 79 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.47616048 |
| 80 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.45769779 |
| 81 | Prion diseases_Homo sapiens_hsa05020 | 0.45202773 |
| 82 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.45042525 |
| 83 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.45025803 |
| 84 | Circadian rhythm_Homo sapiens_hsa04710 | 0.44720253 |
| 85 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.44719155 |
| 86 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.44308954 |
| 87 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.44182690 |
| 88 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.42223205 |
| 89 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.41982382 |
| 90 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.41104876 |
| 91 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.40171514 |
| 92 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.39714653 |
| 93 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.39499228 |
| 94 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.39379639 |
| 95 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.35159351 |
| 96 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.34227843 |
| 97 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.33519383 |
| 98 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.32212991 |
| 99 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.31775037 |
| 100 | Alzheimers disease_Homo sapiens_hsa05010 | 0.29354160 |
| 101 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.28268076 |
| 102 | Colorectal cancer_Homo sapiens_hsa05210 | 0.28243848 |
| 103 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.27645026 |
| 104 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.26957990 |
| 105 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.25370516 |
| 106 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.25192929 |
| 107 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.24504928 |
| 108 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.24091678 |
| 109 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.24081092 |
| 110 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.23645996 |
| 111 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.23098625 |
| 112 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.20462330 |

