SHISA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)6.60082706
2positive regulation of synapse maturation (GO:0090129)5.72999965
3glutamate secretion (GO:0014047)5.72993270
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.64567646
5DNA deamination (GO:0045006)5.55915710
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.18648183
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.12817666
8ribosomal small subunit assembly (GO:0000028)5.06664717
9synaptic vesicle maturation (GO:0016188)4.93920678
10negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.89146176
11DNA strand elongation involved in DNA replication (GO:0006271)4.71013896
12negative regulation of erythrocyte differentiation (GO:0045647)4.70270819
13platelet dense granule organization (GO:0060155)4.59442515
14telomere maintenance via semi-conservative replication (GO:0032201)4.59058822
15neurotransmitter secretion (GO:0007269)4.57001627
16viral transcription (GO:0019083)4.56894324
17DNA strand elongation (GO:0022616)4.49461650
18gonadal mesoderm development (GO:0007506)4.44492697
19cellular potassium ion homeostasis (GO:0030007)4.44079327
20DNA unwinding involved in DNA replication (GO:0006268)4.43096458
21translational termination (GO:0006415)4.33702772
22sodium ion export (GO:0071436)4.31142488
23mature B cell differentiation involved in immune response (GO:0002313)4.29731617
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.29055394
25positive regulation of B cell differentiation (GO:0045579)4.21445285
26DNA replication initiation (GO:0006270)4.20953404
27antigen processing and presentation via MHC class Ib (GO:0002475)4.20950343
28ionotropic glutamate receptor signaling pathway (GO:0035235)4.17273064
29cerebellar granule cell differentiation (GO:0021707)4.16924989
30regulation of short-term neuronal synaptic plasticity (GO:0048172)4.11171536
31activation of MAPKKK activity (GO:0000185)4.09149853
32regulation of synapse maturation (GO:0090128)4.06474893
33regulation of B cell differentiation (GO:0045577)4.05752908
34regulation of ARF protein signal transduction (GO:0032012)4.01419477
35mitotic G1 DNA damage checkpoint (GO:0031571)3.92159931
36translational elongation (GO:0006414)3.91671092
37cytoplasmic sequestering of transcription factor (GO:0042994)3.75496660
38telomere maintenance via recombination (GO:0000722)3.73631732
39positive regulation of membrane potential (GO:0045838)3.71190805
40maturation of SSU-rRNA (GO:0030490)3.68660106
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.68291461
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.68291461
43immunoglobulin mediated immune response (GO:0016064)3.67262186
44regulation of synaptic vesicle exocytosis (GO:2000300)3.67074684
45pseudouridine synthesis (GO:0001522)3.61920803
46locomotory exploration behavior (GO:0035641)3.61351197
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.59121496
48regulation of neuronal synaptic plasticity (GO:0048168)3.58911546
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57303520
50endosome to pigment granule transport (GO:0043485)3.56886269
51endosome to melanosome transport (GO:0035646)3.56886269
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54575647
53mature B cell differentiation (GO:0002335)3.53056039
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.52801039
55lymphoid progenitor cell differentiation (GO:0002320)3.51415832
56regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51293794
57regulation of long-term neuronal synaptic plasticity (GO:0048169)3.50430143
58positive regulation of protein homooligomerization (GO:0032464)3.50194253
59B cell homeostasis (GO:0001782)3.48346615
60SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47621724
61cotranslational protein targeting to membrane (GO:0006613)3.46231590
62ribosomal small subunit biogenesis (GO:0042274)3.42853806
63IMP metabolic process (GO:0046040)3.41261963
64viral life cycle (GO:0019058)3.40892265
65protein targeting to ER (GO:0045047)3.40461642
66positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.39454107
67regulation of interleukin-13 production (GO:0032656)3.39379091
68neuromuscular process controlling balance (GO:0050885)3.39240139
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38674061
70regulation of mammary gland epithelial cell proliferation (GO:0033599)3.37415113
71antigen processing and presentation of endogenous antigen (GO:0019883)3.36018607
72mitotic G1/S transition checkpoint (GO:0044819)3.35555325
73positive regulation of protein oligomerization (GO:0032461)3.33420286
74response to interferon-beta (GO:0035456)3.33133541
75regulation of apoptotic process involved in morphogenesis (GO:1902337)3.32947280
76establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30814319
77mitotic recombination (GO:0006312)3.30568535
78negative regulation of toll-like receptor signaling pathway (GO:0034122)3.30530531
79positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.29668409
80peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.28711245
81neurotransmitter transport (GO:0006836)3.28640698
82translational initiation (GO:0006413)3.28325306
83proline biosynthetic process (GO:0006561)3.24445975
84folic acid-containing compound biosynthetic process (GO:0009396)3.23964184
85protein localization to endoplasmic reticulum (GO:0070972)3.23710205
86IMP biosynthetic process (GO:0006188)3.21240454
87telomere maintenance via telomere lengthening (GO:0010833)3.19527175
88G1 DNA damage checkpoint (GO:0044783)3.16870156
89regulation of regulatory T cell differentiation (GO:0045589)3.16207947
90cellular protein complex disassembly (GO:0043624)3.15599434
91peptidyl-tyrosine autophosphorylation (GO:0038083)3.15213243
92CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.14681855
93regulation of glutamate receptor signaling pathway (GO:1900449)3.13072242
94lipopolysaccharide biosynthetic process (GO:0009103)3.12651939
95nucleobase biosynthetic process (GO:0046112)3.12104347
96positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.11676969
97regulation of vesicle fusion (GO:0031338)3.10649606
98megakaryocyte development (GO:0035855)3.09994107
99regulation of T cell tolerance induction (GO:0002664)3.09114756
100protein complex disassembly (GO:0043241)3.04969887
101regulation of synaptic plasticity (GO:0048167)3.01877471
102thymic T cell selection (GO:0045061)3.01729291
103regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00951131
104histone H4-K12 acetylation (GO:0043983)3.00927148
105regulation of synapse structural plasticity (GO:0051823)2.99334879
106positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.96528911
107L-amino acid import (GO:0043092)2.95968908
108pteridine-containing compound biosynthetic process (GO:0042559)2.93333680
109B cell mediated immunity (GO:0019724)2.93022071
110negative regulation of B cell apoptotic process (GO:0002903)2.92218855
111positive regulation of T cell mediated cytotoxicity (GO:0001916)2.91081703
112mitochondrial calcium ion transport (GO:0006851)2.90984283
113mucosal-associated lymphoid tissue development (GO:0048537)2.89701512
114Peyers patch development (GO:0048541)2.89701512
115cytoplasmic sequestering of protein (GO:0051220)2.88993045
116regulation of synaptic vesicle transport (GO:1902803)2.88705099
117negative regulation of mRNA processing (GO:0050686)2.87463400
118glycine transport (GO:0015816)2.87119212
119defense response to protozoan (GO:0042832)2.87083636
120regulation of interferon-gamma biosynthetic process (GO:0045072)2.86373027
121layer formation in cerebral cortex (GO:0021819)2.85653643
122neuronal ion channel clustering (GO:0045161)2.85550281
123axon ensheathment in central nervous system (GO:0032291)2.84784218
124central nervous system myelination (GO:0022010)2.84784218
125regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84552789
126glutamate receptor signaling pathway (GO:0007215)2.84456042
127regulation of neurotransmitter levels (GO:0001505)2.83002248
128T-helper 1 type immune response (GO:0042088)2.82425798
129regulation of NFAT protein import into nucleus (GO:0051532)2.82292460
130nuclear-transcribed mRNA catabolic process (GO:0000956)2.81858524
131cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80817172
132myelin maintenance (GO:0043217)2.80700116
133signal complex assembly (GO:0007172)2.78886671
134peripheral nervous system neuron development (GO:0048935)2.77572615
135macromolecular complex disassembly (GO:0032984)2.77137117
136regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.75945650
137B cell activation involved in immune response (GO:0002312)2.75672497
138regulation of neurotransmitter secretion (GO:0046928)2.73342087
139synaptic transmission, glutamatergic (GO:0035249)2.73229023
140definitive hemopoiesis (GO:0060216)2.73024592
141mRNA catabolic process (GO:0006402)2.72441119
142neuronal action potential propagation (GO:0019227)2.71915133
143base-excision repair, AP site formation (GO:0006285)2.71216498
144positive regulation of tolerance induction (GO:0002645)2.70586567
145melanosome organization (GO:0032438)2.69712545
146ribonucleoprotein complex biogenesis (GO:0022613)2.69047874
147regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.67609679
148RNA catabolic process (GO:0006401)2.67265678
149positive regulation of Rap GTPase activity (GO:0032854)2.66636212
150pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.65780266
151somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.65635854
152somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.65635854
153isotype switching (GO:0045190)2.65635854
154lymph node development (GO:0048535)2.65273721
155translesion synthesis (GO:0019985)2.65120229
156DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.64457116
157heterochromatin organization (GO:0070828)2.64383364
158positive thymic T cell selection (GO:0045059)2.64002266
159cerebellar Purkinje cell differentiation (GO:0021702)2.63678982
160cell migration in hindbrain (GO:0021535)2.62902891
161mitochondrial DNA replication (GO:0006264)2.62677045
162potassium ion import (GO:0010107)2.62443247
163vocalization behavior (GO:0071625)2.62162130
164lymph vessel development (GO:0001945)2.60848053
165positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.60281658
166regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.60281658
167B cell receptor signaling pathway (GO:0050853)2.60237960
168mast cell activation (GO:0045576)2.60223699
169formation of translation preinitiation complex (GO:0001731)2.59403608
170exploration behavior (GO:0035640)2.58980247
171regulation of postsynaptic membrane potential (GO:0060078)2.58302104
172cellular response to thyroid hormone stimulus (GO:0097067)2.58261945
173intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.58163735
174DNA damage response, signal transduction resulting in transcription (GO:0042772)2.58070543
175amino acid import (GO:0043090)2.57345305
176regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.57176715
177peptidyl-arginine omega-N-methylation (GO:0035247)2.56202879
178histone H3 deacetylation (GO:0070932)2.56025242
179potassium ion homeostasis (GO:0055075)2.55632671
180rRNA processing (GO:0006364)2.55396402
181L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54839875
182purine nucleobase biosynthetic process (GO:0009113)2.54787108
183pigment granule organization (GO:0048753)2.54759516
184fucose catabolic process (GO:0019317)2.53842705
185L-fucose metabolic process (GO:0042354)2.53842705
186L-fucose catabolic process (GO:0042355)2.53842705
187respiratory chain complex IV assembly (GO:0008535)2.53560058
188positive regulation of defense response to virus by host (GO:0002230)2.53353140
189positive regulation of CREB transcription factor activity (GO:0032793)2.53287038
190prepulse inhibition (GO:0060134)2.53058711
191secretory granule organization (GO:0033363)2.52540940
192positive regulation of gene expression, epigenetic (GO:0045815)2.52369999
193regulation of T cell mediated cytotoxicity (GO:0001914)2.51288147
194sex determination (GO:0007530)2.51086000
195positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.51064501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.66840693
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43866364
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.33622923
4SCL_19346495_ChIP-Seq_HPC-7_Human3.32364915
5MYC_22102868_ChIP-Seq_BL_Human3.28407831
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.92534355
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.90859698
8VDR_21846776_ChIP-Seq_THP-1_Human2.90390175
9SRY_22984422_ChIP-ChIP_TESTIS_Rat2.71391879
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60261178
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.50320911
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.46079091
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.38333885
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32051174
15TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.30806914
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26828950
17P68_20966046_ChIP-Seq_HELA_Human2.24093866
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.22177612
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20910831
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09626265
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08401278
22CIITA_25753668_ChIP-Seq_RAJI_Human1.96783292
23KDM2B_26808549_Chip-Seq_K562_Human1.96170463
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95947841
25SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.93070515
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.91259795
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90672814
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.88771440
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87834522
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86302807
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.86118272
32VDR_24763502_ChIP-Seq_THP-1_Human1.85157470
33XRN2_22483619_ChIP-Seq_HELA_Human1.83041634
34TCF7_22412390_ChIP-Seq_EML_Mouse1.82649677
35ERG_20887958_ChIP-Seq_HPC-7_Mouse1.81524344
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.80657318
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80585106
38EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.78885016
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78236283
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.77555025
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77016687
42RACK7_27058665_Chip-Seq_MCF-7_Human1.74345814
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73345400
44SPI1_23547873_ChIP-Seq_NB4_Human1.72465627
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.68465255
46VDR_23849224_ChIP-Seq_CD4+_Human1.67486869
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.65871775
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65378349
49MAF_26560356_Chip-Seq_TH1_Human1.65235295
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.64160313
51SMC4_20622854_ChIP-Seq_HELA_Human1.64153593
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62304733
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61805493
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.61612392
55GATA1_22025678_ChIP-Seq_K562_Human1.61481192
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59636217
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59386929
58GABP_19822575_ChIP-Seq_HepG2_Human1.58411816
59CREB1_26743006_Chip-Seq_LNCaP_Human1.58297657
60EZH2_22144423_ChIP-Seq_EOC_Human1.58106535
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57757240
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.57011676
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56868619
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56717888
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55667100
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.54396411
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54384255
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.53226242
69FOXP3_21729870_ChIP-Seq_TREG_Human1.52818489
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51891515
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50477538
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49943014
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49520616
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49312701
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47405355
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46846033
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46767505
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45420046
79UTX_26944678_Chip-Seq_JUKART_Human1.45177269
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42538099
81EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42372958
82RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42372958
83KDM2B_26808549_Chip-Seq_DND41_Human1.41699481
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.41400834
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40517206
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40018416
87ZNF263_19887448_ChIP-Seq_K562_Human1.38142534
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.37879717
89MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37079697
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36598657
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36499524
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36467180
93CTCF_27219007_Chip-Seq_Bcells_Human1.35697301
94MYB_26560356_Chip-Seq_TH2_Human1.33940799
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31875815
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31708958
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30911588
98GABP_17652178_ChIP-ChIP_JURKAT_Human1.30249757
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29904549
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29696725
101DCP1A_22483619_ChIP-Seq_HELA_Human1.29552068
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28061058
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27150361
104FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26615151
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25538067
106FOXM1_23109430_ChIP-Seq_U2OS_Human1.24779205
107KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24412275
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24043520
109REST_18959480_ChIP-ChIP_MESCs_Mouse1.23828911
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23569786
111MYB_26560356_Chip-Seq_TH1_Human1.23489916
112E2F1_21310950_ChIP-Seq_MCF-7_Human1.22599936
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22581791
114CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22257674
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21756246
116LXR_22292898_ChIP-Seq_THP-1_Human1.20210307
117MAF_26560356_Chip-Seq_TH2_Human1.19564265
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18769288
119TTF2_22483619_ChIP-Seq_HELA_Human1.18629658
120RNF2_27304074_Chip-Seq_ESCs_Mouse1.18192671
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18021288
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17858441
123DROSHA_22980978_ChIP-Seq_HELA_Human1.17629025
124PHF8_20622854_ChIP-Seq_HELA_Human1.17460470
125MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16980723
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16631674
127ELK3_25401928_ChIP-Seq_HUVEC_Human1.16135157
128CTCF_26484167_Chip-Seq_Bcells_Mouse1.15397737
129HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15003842
130STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14966198
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14256672
132SA1_27219007_Chip-Seq_Bcells_Human1.13455169
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13128040
134PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13121999
135MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12902964
136KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12322655
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11478855
138BCL6_27268052_Chip-Seq_Bcells_Human1.10748613
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10574708
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10277385
141SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10091038
142AR_21909140_ChIP-Seq_LNCAP_Human1.09602696
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08840198
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08803564
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08203087
146HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08183045
147TP53_20018659_ChIP-ChIP_R1E_Mouse1.07967866
148FOXP1_21924763_ChIP-Seq_HESCs_Human1.07368617
149EED_16625203_ChIP-ChIP_MESCs_Mouse1.07277558
150CTCF_20526341_ChIP-Seq_ESCs_Human1.07178114
151E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06967305
152SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05589947
153SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05266579
154CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05265306
155CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05118872
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04571469
157MYC_18940864_ChIP-ChIP_HL60_Human1.04527878
158NCOR1_26117541_ChIP-Seq_K562_Human1.04484347
159E2F1_20622854_ChIP-Seq_HELA_Human1.04335946
160TP63_17297297_ChIP-ChIP_HaCaT_Human1.04080639
161SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03342000
162GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03341429
163MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03273706
164PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03179957
165SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02148705
166STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00930302
167KDM5A_27292631_Chip-Seq_BREAST_Human1.00707326
168POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99650648
169GATA1_19941827_ChIP-Seq_MEL_Mouse0.99376397
170GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98845606
171BCOR_27268052_Chip-Seq_Bcells_Human0.98525730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.47300612
2MP0002396_abnormal_hematopoietic_system4.80065514
3MP0005423_abnormal_somatic_nervous4.65101734
4MP0005645_abnormal_hypothalamus_physiol3.94358111
5MP0000685_abnormal_immune_system3.55287746
6MP0005623_abnormal_meninges_morphology3.52408109
7MP0004147_increased_porphyrin_level3.38915036
8MP0001346_abnormal_lacrimal_gland3.26764090
9MP0001348_abnormal_lacrimal_gland3.14001340
10MP0003635_abnormal_synaptic_transmissio2.96604121
11MP0005174_abnormal_tail_pigmentation2.90940750
12MP0008995_early_reproductive_senescence2.82738329
13MP0010094_abnormal_chromosome_stability2.82325157
14MP0009046_muscle_twitch2.77548333
15MP0001835_abnormal_antigen_presentation2.71802033
16MP0002064_seizures2.67494674
17MP0003866_abnormal_defecation2.67149591
18MP0003880_abnormal_central_pattern2.66824998
19MP0002249_abnormal_larynx_morphology2.57657171
20MP0008877_abnormal_DNA_methylation2.40739155
21MP0004808_abnormal_hematopoietic_stem2.32840604
22MP0005075_abnormal_melanosome_morpholog2.31401329
23MP0004270_analgesia2.30930390
24MP0009745_abnormal_behavioral_response2.30537608
25MP0004957_abnormal_blastocyst_morpholog2.29704942
26MP0000013_abnormal_adipose_tissue2.28295358
27MP0001502_abnormal_circadian_rhythm2.22178486
28MP0003693_abnormal_embryo_hatching2.21336296
29MP0001545_abnormal_hematopoietic_system2.19873001
30MP0005397_hematopoietic_system_phenotyp2.19873001
31MP0000678_abnormal_parathyroid_gland2.18940018
32MP0002398_abnormal_bone_marrow2.17999680
33MP0003077_abnormal_cell_cycle2.17486465
34MP0008058_abnormal_DNA_repair2.15606671
35MP0002063_abnormal_learning/memory/cond2.13809749
36MP0001800_abnormal_humoral_immune2.10352927
37MP0002272_abnormal_nervous_system2.09101074
38MP0000689_abnormal_spleen_morphology2.03426145
39MP0005671_abnormal_response_to2.00450874
40MP0008057_abnormal_DNA_replication1.97792729
41MP0008007_abnormal_cellular_replicative1.97705371
42MP0000490_abnormal_crypts_of1.94590622
43MP0009785_altered_susceptibility_to1.88519542
44MP0002877_abnormal_melanocyte_morpholog1.84598373
45MP0003763_abnormal_thymus_physiology1.82548493
46MP0002095_abnormal_skin_pigmentation1.82347791
47MP0003786_premature_aging1.81805048
48MP0002420_abnormal_adaptive_immunity1.80728063
49MP0000003_abnormal_adipose_tissue1.79336466
50MP0000716_abnormal_immune_system1.78665917
51MP0002452_abnormal_antigen_presenting1.77978610
52MP0002723_abnormal_immune_serum1.77307221
53MP0002722_abnormal_immune_system1.75486837
54MP0001819_abnormal_immune_cell1.73958966
55MP0005025_abnormal_response_to1.73278807
56MP0002734_abnormal_mechanical_nocicepti1.72829730
57MP0001188_hyperpigmentation1.72810561
58MP0001968_abnormal_touch/_nociception1.68881059
59MP0002429_abnormal_blood_cell1.68767401
60MP0002163_abnormal_gland_morphology1.61772964
61MP0002019_abnormal_tumor_incidence1.61713148
62MP0003879_abnormal_hair_cell1.60297549
63MP0001790_abnormal_immune_system1.58335177
64MP0005387_immune_system_phenotype1.58335177
65MP0002210_abnormal_sex_determination1.57159909
66MP0004885_abnormal_endolymph1.54755389
67MP0005499_abnormal_olfactory_system1.48736060
68MP0005394_taste/olfaction_phenotype1.48736060
69MP0005000_abnormal_immune_tolerance1.47471295
70MP0000465_gastrointestinal_hemorrhage1.46350490
71MP0002572_abnormal_emotion/affect_behav1.45949972
72MP0004142_abnormal_muscle_tone1.45001091
73MP0001929_abnormal_gametogenesis1.45000620
74MP0001853_heart_inflammation1.40368455
75MP0001145_abnormal_male_reproductive1.38258891
76MP0005464_abnormal_platelet_physiology1.36390028
77MP0003111_abnormal_nucleus_morphology1.36270181
78MP0002148_abnormal_hypersensitivity_rea1.36077081
79MP0004811_abnormal_neuron_physiology1.31317209
80MP0004742_abnormal_vestibular_system1.31231670
81MP0003045_fibrosis1.30767940
82MP0000703_abnormal_thymus_morphology1.30384751
83MP0009278_abnormal_bone_marrow1.29212435
84MP0000015_abnormal_ear_pigmentation1.28423088
85MP0003878_abnormal_ear_physiology1.28042649
86MP0005377_hearing/vestibular/ear_phenot1.28042649
87MP0002735_abnormal_chemical_nociception1.22545362
88MP0009379_abnormal_foot_pigmentation1.22201395
89MP0002557_abnormal_social/conspecific_i1.21894681
90MP0000350_abnormal_cell_proliferation1.21861785
91MP0001270_distended_abdomen1.21738100
92MP0000313_abnormal_cell_death1.21237692
93MP0005375_adipose_tissue_phenotype1.19029324
94MP0008874_decreased_physiological_sensi1.18913244
95MP0001873_stomach_inflammation1.18157754
96MP0000653_abnormal_sex_gland1.17072962
97MP0002089_abnormal_postnatal_growth/wei1.15690893
98MP0005076_abnormal_cell_differentiation1.14472997
99MP0010155_abnormal_intestine_physiology1.12283408
100MP0001486_abnormal_startle_reflex1.09740963
101MP0000920_abnormal_myelination1.08733981
102MP0005670_abnormal_white_adipose1.07948637
103MP0002066_abnormal_motor_capabilities/c1.07733997
104MP0008569_lethality_at_weaning1.06357966
105MP0001730_embryonic_growth_arrest1.05968357
106MP0003646_muscle_fatigue1.05886518
107MP0002184_abnormal_innervation1.04604437
108MP0002733_abnormal_thermal_nociception1.00804072
109MP0002166_altered_tumor_susceptibility1.00756980
110MP0003329_amyloid_beta_deposits1.00389680
111MP0002405_respiratory_system_inflammati0.99225583
112MP0002234_abnormal_pharynx_morphology0.97290083
113MP0002653_abnormal_ependyma_morphology0.96585899
114MP0002067_abnormal_sensory_capabilities0.96316658
115MP0003303_peritoneal_inflammation0.95073917
116MP0002736_abnormal_nociception_after0.94848584
117MP0009333_abnormal_splenocyte_physiolog0.94026228
118MP0001970_abnormal_pain_threshold0.93516935
119MP0006292_abnormal_olfactory_placode0.92902497
120MP0001919_abnormal_reproductive_system0.92845528
121MP0002938_white_spotting0.91274177
122MP0002882_abnormal_neuron_morphology0.91269212
123MP0001440_abnormal_grooming_behavior0.90385158
124MP0001501_abnormal_sleep_pattern0.89306126
125MP0003315_abnormal_perineum_morphology0.85709919
126MP0003656_abnormal_erythrocyte_physiolo0.85572406
127MP0003698_abnormal_male_reproductive0.84666297
128MP0004145_abnormal_muscle_electrophysio0.83289829
129MP0008932_abnormal_embryonic_tissue0.81895412
130MP0002419_abnormal_innate_immunity0.80078187
131MP0003172_abnormal_lysosome_physiology0.77620534
132MP0002080_prenatal_lethality0.77507767
133MP0000955_abnormal_spinal_cord0.77417165
134MP0002152_abnormal_brain_morphology0.77371747
135MP0010678_abnormal_skin_adnexa0.76204884
136MP0004185_abnormal_adipocyte_glucose0.75506106
137MP0000681_abnormal_thyroid_gland0.75294892
138MP0004947_skin_inflammation0.74704943
139MP0000477_abnormal_intestine_morphology0.74220786
140MP0002006_tumorigenesis0.73929605
141MP0006036_abnormal_mitochondrial_physio0.73202412
142MP0003183_abnormal_peptide_metabolism0.73071083
143MP0002083_premature_death0.72973462
144MP0000613_abnormal_salivary_gland0.72871571
145MP0001845_abnormal_inflammatory_respons0.72791721
146MP0001697_abnormal_embryo_size0.72554027
147MP0003938_abnormal_ear_development0.71793704
148MP0001986_abnormal_taste_sensitivity0.71100439
149MP0000778_abnormal_nervous_system0.70995310
150MP0005666_abnormal_adipose_tissue0.70215926
151MP0000639_abnormal_adrenal_gland0.68661547
152MP0003633_abnormal_nervous_system0.66983718
153MP0003567_abnormal_fetal_cardiomyocyte0.66183001
154MP0002160_abnormal_reproductive_system0.65608461
155MP0009765_abnormal_xenobiotic_induced0.65284928
156MP0003634_abnormal_glial_cell0.64905273
157MP0003718_maternal_effect0.64758473
158MP0005310_abnormal_salivary_gland0.64676870
159MP0002873_normal_phenotype0.64006620
160MP0001881_abnormal_mammary_gland0.63572860
161MP0001963_abnormal_hearing_physiology0.63524578
162MP0002169_no_abnormal_phenotype0.63444211
163MP0002161_abnormal_fertility/fecundity0.63407068
164MP0000537_abnormal_urethra_morphology0.63372278
165MP0002075_abnormal_coat/hair_pigmentati0.63296354
166MP0003631_nervous_system_phenotype0.62292429
167MP0002177_abnormal_outer_ear0.61058083
168MP0004510_myositis0.59800734
169MP0005379_endocrine/exocrine_gland_phen0.59479720
170MP0010769_abnormal_survival0.57993709
171MP0004381_abnormal_hair_follicle0.57108513

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)5.34073520
2Myokymia (HP:0002411)5.31656122
3Aplastic anemia (HP:0001915)5.29392754
4Annular pancreas (HP:0001734)5.02741929
5Thrombocytosis (HP:0001894)5.00439947
6Gonadal dysgenesis (HP:0000133)4.68885439
7Chronic otitis media (HP:0000389)4.56422987
8Elevated erythrocyte sedimentation rate (HP:0003565)4.37889613
9Gastrointestinal stroma tumor (HP:0100723)3.57873496
10Cerebral hypomyelination (HP:0006808)3.54425198
11Recurrent bronchitis (HP:0002837)3.51156846
12Focal motor seizures (HP:0011153)3.49857167
13Colitis (HP:0002583)3.40939684
14Abnormality of cells of the erythroid lineage (HP:0012130)3.39786274
15Absence seizures (HP:0002121)3.34550517
16Interstitial pulmonary disease (HP:0006530)3.34129430
17Panhypogammaglobulinemia (HP:0003139)3.32417773
18Myositis (HP:0100614)3.29623079
19Recurrent sinusitis (HP:0011108)3.23877442
20Supranuclear gaze palsy (HP:0000605)3.17035217
21Abnormal number of erythroid precursors (HP:0012131)3.09048794
22Gastrointestinal inflammation (HP:0004386)3.03976356
23Cellulitis (HP:0100658)3.03729979
24Agammaglobulinemia (HP:0004432)2.98985168
25Male infertility (HP:0003251)2.98412460
26Generalized tonic-clonic seizures (HP:0002069)2.96747137
27Gonadotropin excess (HP:0000837)2.93536357
28Reticulocytopenia (HP:0001896)2.91303118
29CNS hypomyelination (HP:0003429)2.90928459
30Inflammation of the large intestine (HP:0002037)2.90874321
31Double outlet right ventricle (HP:0001719)2.90541334
32Congenital malformation of the right heart (HP:0011723)2.90541334
33Abnormality of T cell physiology (HP:0011840)2.90018382
34Obstructive sleep apnea (HP:0002870)2.88744904
35Erythema (HP:0010783)2.87320145
36Colon cancer (HP:0003003)2.87060523
37Broad face (HP:0000283)2.84126046
38Type I transferrin isoform profile (HP:0003642)2.81328053
39Epileptic encephalopathy (HP:0200134)2.80997800
40Impaired smooth pursuit (HP:0007772)2.80353467
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78787521
42Visual hallucinations (HP:0002367)2.77802466
43Abnormality of the nasal mucosa (HP:0000433)2.77336064
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.76878363
45Dysmetric saccades (HP:0000641)2.71861504
46Acute lymphatic leukemia (HP:0006721)2.71689503
47Poikiloderma (HP:0001029)2.70728023
48Truncus arteriosus (HP:0001660)2.69826743
49Unilateral renal agenesis (HP:0000122)2.64657593
50Poor eye contact (HP:0000817)2.62814887
51Acute myeloid leukemia (HP:0004808)2.62688783
52Depression (HP:0000716)2.62378790
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.60105570
54Stridor (HP:0010307)2.59095928
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56752819
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56752819
57Action tremor (HP:0002345)2.56169499
58Athetosis (HP:0002305)2.54028881
59Ankle clonus (HP:0011448)2.53896953
60Septate vagina (HP:0001153)2.48053280
61Cholecystitis (HP:0001082)2.46564299
62Abnormal gallbladder physiology (HP:0012438)2.46564299
63Fatigue (HP:0012378)2.44390063
64Macrocytic anemia (HP:0001972)2.43539731
65Tetany (HP:0001281)2.43015146
66Focal seizures (HP:0007359)2.42785124
67Lymphoma (HP:0002665)2.42422410
68Febrile seizures (HP:0002373)2.42304015
69Pancytopenia (HP:0001876)2.41043204
70Dialeptic seizures (HP:0011146)2.39930166
71Emphysema (HP:0002097)2.39853907
72Pointed chin (HP:0000307)2.38512889
73IgG deficiency (HP:0004315)2.38035352
74Abnormality of binocular vision (HP:0011514)2.37554635
75Diplopia (HP:0000651)2.37554635
76Hypertensive crisis (HP:0100735)2.37071769
77Lower limb asymmetry (HP:0100559)2.35594644
78Truncal ataxia (HP:0002078)2.35481274
79Deep palmar crease (HP:0006191)2.34562742
80Postural instability (HP:0002172)2.34250801
81Lymphopenia (HP:0001888)2.33870322
82Transposition of the great arteries (HP:0001669)2.33738697
83Abnormal connection of the cardiac segments (HP:0011545)2.33738697
84Abnormal ventriculo-arterial connection (HP:0011563)2.33738697
85Akinesia (HP:0002304)2.30486604
86Neoplasm of the oral cavity (HP:0100649)2.29795180
87Overriding aorta (HP:0002623)2.29114673
88Ulnar bowing (HP:0003031)2.29029840
89Basal cell carcinoma (HP:0002671)2.28393692
90Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27468896
91Abnormality of cells of the lymphoid lineage (HP:0012140)2.26148708
92Abnormal sex determination (HP:0012244)2.23188601
93Sex reversal (HP:0012245)2.23188601
94Amaurosis fugax (HP:0100576)2.22075760
95Nasal polyposis (HP:0100582)2.20885040
96Hyperacusis (HP:0010780)2.20806801
97Broad distal phalanx of finger (HP:0009836)2.20624145
98Reduced antithrombin III activity (HP:0001976)2.19982466
99Hyperthyroidism (HP:0000836)2.19140121
100Oral leukoplakia (HP:0002745)2.18829690
101Albinism (HP:0001022)2.18512926
102Type II lissencephaly (HP:0007260)2.16659086
103Severe visual impairment (HP:0001141)2.15979417
104Abnormality of DNA repair (HP:0003254)2.15245641
105Pulmonary fibrosis (HP:0002206)2.13915559
106Entropion (HP:0000621)2.13527293
107IgA deficiency (HP:0002720)2.13107344
108Turricephaly (HP:0000262)2.12916263
109Abnormal protein N-linked glycosylation (HP:0012347)2.11245047
110Abnormal protein glycosylation (HP:0012346)2.11245047
111Abnormal glycosylation (HP:0012345)2.11245047
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11245047
113Hepatocellular necrosis (HP:0001404)2.11155697
114Mesangial abnormality (HP:0001966)2.10742407
115B lymphocytopenia (HP:0010976)2.10039155
116Abnormality of B cell number (HP:0010975)2.10039155
117Nonprogressive disorder (HP:0003680)2.08888607
118Progressive cerebellar ataxia (HP:0002073)2.08800154
119Secondary amenorrhea (HP:0000869)2.08280986
120Restrictive lung disease (HP:0002091)2.07432398
121Optic nerve coloboma (HP:0000588)2.06866210
122Ragged-red muscle fibers (HP:0003200)2.06384541
123Bronchitis (HP:0012387)2.04624192
124Abnormality of macrophages (HP:0004311)2.03849300
125Dysmetria (HP:0001310)2.03485456
126Abnormality of the columella (HP:0009929)2.02484997
127Intestinal fistula (HP:0100819)2.01548174
128Pallor (HP:0000980)2.01107793
129Impaired social interactions (HP:0000735)2.00929296
130Abnormal social behavior (HP:0012433)2.00929296
131Abnormality of ocular smooth pursuit (HP:0000617)2.00282672
132Long palpebral fissure (HP:0000637)1.98704915
133Elfin facies (HP:0004428)1.98249117
134Male pseudohermaphroditism (HP:0000037)1.98086590
135Vasculitis (HP:0002633)1.98011649
136Progressive muscle weakness (HP:0003323)1.96760470
137Insomnia (HP:0100785)1.96521754
138Delusions (HP:0000746)1.95637328
139Selective tooth agenesis (HP:0001592)1.95372759
140Stereotypic behavior (HP:0000733)1.94358062
141Spastic gait (HP:0002064)1.94280775
142Broad alveolar ridges (HP:0000187)1.94017632
143Ocular albinism (HP:0001107)1.93434849
144Abnormality of male internal genitalia (HP:0000022)1.93419861
145Squamous cell carcinoma (HP:0002860)1.93378597
146Rectal fistula (HP:0100590)1.92832191
147Rectovaginal fistula (HP:0000143)1.92832191
148Cutaneous melanoma (HP:0012056)1.92075036
149Periauricular skin pits (HP:0100277)1.91340101
150Preauricular pit (HP:0004467)1.91340101
151Recurrent viral infections (HP:0004429)1.90812735
152Abnormality of saccadic eye movements (HP:0000570)1.90047094
153Recurrent otitis media (HP:0000403)1.89972031
154Meningitis (HP:0001287)1.88720835
155Atonic seizures (HP:0010819)1.88539482
156Postnatal microcephaly (HP:0005484)1.86813195
157Hypoproteinemia (HP:0003075)1.86249141
158Birth length less than 3rd percentile (HP:0003561)1.85305362
159Facial diplegia (HP:0001349)1.84495370
160Abnormality of the aortic arch (HP:0012303)1.84242495
161Abnormality of T cells (HP:0002843)1.84171221
162Myelodysplasia (HP:0002863)1.83860740
163Trigonocephaly (HP:0000243)1.83109853
164Increased purine levels (HP:0004368)1.82298259
165Hyperuricemia (HP:0002149)1.82298259
166Large eyes (HP:0001090)1.81908287
167Asplenia (HP:0001746)1.81723680
168Mediastinal lymphadenopathy (HP:0100721)1.81701764
169Medulloblastoma (HP:0002885)1.81404061
170Bradykinesia (HP:0002067)1.81335665
171Gout (HP:0001997)1.80604315
172Asymmetric growth (HP:0100555)1.79852577
173Polygenic inheritance (HP:0010982)1.79574739
174Neuronal loss in central nervous system (HP:0002529)1.79319057
175Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79248718
176Aplasia/Hypoplasia of the spleen (HP:0010451)1.79122957
177Abnormality of chromosome segregation (HP:0002916)1.78195101
178Microcytic anemia (HP:0001935)1.78072933
179Spastic tetraparesis (HP:0001285)1.76122476
180Hypercortisolism (HP:0001578)1.75279116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT34.65154914
2KIT4.55038759
3SMG14.07755338
4TNIK3.68442310
5TRIB33.60180605
6CSF1R3.55542545
7PRPF4B3.50348753
8EEF2K3.50122825
9MAP3K93.47646200
10WEE13.46687034
11CDK193.08406814
12MAP4K13.01897043
13NME22.88868906
14ARAF2.37194114
15ACVR1B2.34152298
16TGFBR12.31648228
17CDK122.25130314
18RIPK42.18414400
19WNK42.06395599
20CAMKK12.02716546
21MAPKAPK51.96515219
22STK391.96476406
23BTK1.94640820
24BUB11.85229719
25SCYL21.82885367
26NTRK21.63961856
27MATK1.63037381
28RPS6KB21.54432502
29WNK11.51032866
30NEK21.49817541
31DAPK21.47349337
32PKN21.44331702
33JAK31.44182797
34CDK71.43697423
35BCKDK1.43334599
36PAK61.41810733
37BRAF1.40958131
38SIK31.39513292
39PIM21.38312800
40ADRBK21.32499103
41EPHA41.28364417
42SIK21.27029870
43NTRK31.25948628
44CDK41.24949103
45TEC1.24619354
46MAP3K61.23606376
47RIPK11.19130973
48MAPKAPK31.18384390
49TGFBR21.16097953
50PRKCH1.15344268
51MAP3K101.14586003
52EPHB11.08768585
53PRKD31.08504392
54CDC71.06287153
55STK161.05759427
56CDK11A1.04305636
57PDPK11.03825951
58IRAK21.03563024
59SIK11.01665053
60RAF11.01650664
61SYK1.00566443
62NLK0.99413281
63MAP2K30.97640533
64FES0.97110262
65MAPK120.95235221
66MARK20.95105588
67IRAK40.92232668
68MUSK0.91485006
69MAP3K140.91033732
70PKN10.90159753
71CDK150.88441192
72PDK10.87961772
73ALK0.86000171
74BLK0.82376292
75CCNB10.81662974
76MARK10.80297095
77CAMKK20.79903201
78CDK180.79854399
79DAPK10.79382349
80TAOK20.78300582
81BRSK20.78112263
82TYRO30.77848329
83CDK80.76704270
84DAPK30.75690966
85MKNK10.75022110
86MAP3K10.73816931
87LRRK20.72947370
88DYRK30.72056315
89MELK0.71957779
90RPS6KA50.71853797
91CDC42BPA0.71568680
92CDK50.70094413
93CAMK10.70000579
94MAPK150.68488632
95MINK10.67472773
96CDK140.65167087
97IKBKE0.64343811
98CAMK2B0.64131103
99PAK40.63623189
100CSNK1G30.62315957
101LCK0.61860520
102ZAP700.59949480
103CLK10.58335841
104NME10.57612841
105PRKCI0.56768961
106MAP3K130.56081207
107IRAK30.55099400
108FGR0.54646413
109STK100.54509898
110TBK10.53991247
111SGK2230.53361692
112SGK4940.53361692
113PRKCQ0.52004649
114MOS0.51665148
115MAPK100.51618424
116LYN0.50344306
117MAPK110.49389693
118CSNK1A1L0.49010525
119MAP2K20.48736272
120CAMK40.48276793
121VRK20.47627262
122ATR0.47126286
123TNK20.46766399
124CDK20.46282376
125GRK50.46210591
126ERN10.45948554
127BRSK10.45873142
128PIM10.45815407
129VRK10.45411834
130PASK0.44817964
131STK110.44567006
132MAP3K110.43578553
133MAP3K70.43520957
134CHEK20.43394324
135MTOR0.43368059
136BRD40.41293302
137TAOK10.40202884
138PLK10.39171255
139MARK30.38985620
140RPS6KA40.38693438
141CDK90.37761842
142CHUK0.37597267
143KSR10.36736158
144CSNK1G10.36632206
145TYK20.36164684
146MAPK80.36149708
147HIPK20.35952700
148DYRK20.34930975
149AKT20.34926934
150GRK60.30524234
151ICK0.28041460
152RET0.27727944
153IKBKB0.27358264
154KSR20.26007762
155MAP3K80.25798574
156UHMK10.25080424
157TLK10.24848338
158ILK0.23842899
159STK40.23432177
160PAK10.23064168
161CHEK10.22753783
162AURKA0.22605327

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.85763882
2Mismatch repair_Homo sapiens_hsa034304.22176630
3Base excision repair_Homo sapiens_hsa034103.75234756
4Ribosome_Homo sapiens_hsa030103.65441404
5Nicotine addiction_Homo sapiens_hsa050332.89467585
6Allograft rejection_Homo sapiens_hsa053302.89112519
7Synaptic vesicle cycle_Homo sapiens_hsa047212.88474514
8Nucleotide excision repair_Homo sapiens_hsa034202.76972217
9Autoimmune thyroid disease_Homo sapiens_hsa053202.61750984
10RNA polymerase_Homo sapiens_hsa030202.56028894
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53971511
12Pyrimidine metabolism_Homo sapiens_hsa002402.41374019
13Homologous recombination_Homo sapiens_hsa034402.40338270
14Type I diabetes mellitus_Homo sapiens_hsa049402.38870681
15Spliceosome_Homo sapiens_hsa030402.31505943
16Primary immunodeficiency_Homo sapiens_hsa053402.31104866
17Graft-versus-host disease_Homo sapiens_hsa053322.29793885
18B cell receptor signaling pathway_Homo sapiens_hsa046622.18250845
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08057545
20Long-term potentiation_Homo sapiens_hsa047202.06330123
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04948775
22Systemic lupus erythematosus_Homo sapiens_hsa053221.98010540
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92534912
24Cell cycle_Homo sapiens_hsa041101.91074938
25Viral myocarditis_Homo sapiens_hsa054161.82702757
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82020621
27RNA degradation_Homo sapiens_hsa030181.59108929
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58812268
29Asthma_Homo sapiens_hsa053101.57422778
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57358490
31RNA transport_Homo sapiens_hsa030131.55377228
32Amphetamine addiction_Homo sapiens_hsa050311.54791670
33Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.47452488
34Folate biosynthesis_Homo sapiens_hsa007901.45423995
35One carbon pool by folate_Homo sapiens_hsa006701.44520201
36Basal transcription factors_Homo sapiens_hsa030221.44214322
37Sulfur relay system_Homo sapiens_hsa041221.38744512
38Acute myeloid leukemia_Homo sapiens_hsa052211.37436352
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35022534
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27714520
41Antigen processing and presentation_Homo sapiens_hsa046121.26273567
42Fanconi anemia pathway_Homo sapiens_hsa034601.25288020
43Cocaine addiction_Homo sapiens_hsa050301.24564264
44Purine metabolism_Homo sapiens_hsa002301.23686006
45Fatty acid elongation_Homo sapiens_hsa000621.21837349
46Glutamatergic synapse_Homo sapiens_hsa047241.20638730
47Circadian entrainment_Homo sapiens_hsa047131.19437734
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19240658
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18913535
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16588996
51Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11950573
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11357489
53Shigellosis_Homo sapiens_hsa051311.10418284
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10318543
55Herpes simplex infection_Homo sapiens_hsa051681.09721984
56Thyroid cancer_Homo sapiens_hsa052161.08406737
57GABAergic synapse_Homo sapiens_hsa047271.07816598
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07547422
59Non-homologous end-joining_Homo sapiens_hsa034501.06792765
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05684237
61Morphine addiction_Homo sapiens_hsa050321.05683910
62Proteasome_Homo sapiens_hsa030501.01777355
63mTOR signaling pathway_Homo sapiens_hsa041501.01735416
64Glioma_Homo sapiens_hsa052141.00185666
65Fructose and mannose metabolism_Homo sapiens_hsa000510.94240522
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.93855186
67GnRH signaling pathway_Homo sapiens_hsa049120.92350708
68Cholinergic synapse_Homo sapiens_hsa047250.92290512
69ErbB signaling pathway_Homo sapiens_hsa040120.92088020
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90443771
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87558013
72N-Glycan biosynthesis_Homo sapiens_hsa005100.87269367
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87047705
74Insulin secretion_Homo sapiens_hsa049110.86388367
75Vitamin B6 metabolism_Homo sapiens_hsa007500.85927328
76Epstein-Barr virus infection_Homo sapiens_hsa051690.85005835
77p53 signaling pathway_Homo sapiens_hsa041150.82657217
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80509497
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80357123
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.79400790
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79298510
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76870194
83Platelet activation_Homo sapiens_hsa046110.76793125
84MAPK signaling pathway_Homo sapiens_hsa040100.76790653
85Leishmaniasis_Homo sapiens_hsa051400.76285647
86Gastric acid secretion_Homo sapiens_hsa049710.76047038
87HIF-1 signaling pathway_Homo sapiens_hsa040660.75689474
88Pentose phosphate pathway_Homo sapiens_hsa000300.73463773
89Prion diseases_Homo sapiens_hsa050200.71633030
90cAMP signaling pathway_Homo sapiens_hsa040240.68109895
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.66580188
92VEGF signaling pathway_Homo sapiens_hsa043700.66134236
93Non-small cell lung cancer_Homo sapiens_hsa052230.65919640
94T cell receptor signaling pathway_Homo sapiens_hsa046600.65406204
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64797672
96Notch signaling pathway_Homo sapiens_hsa043300.63186254
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.63154764
98mRNA surveillance pathway_Homo sapiens_hsa030150.63086659
99Estrogen signaling pathway_Homo sapiens_hsa049150.62942978
100Dopaminergic synapse_Homo sapiens_hsa047280.62652004
101Type II diabetes mellitus_Homo sapiens_hsa049300.61679631
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61260678
103Oocyte meiosis_Homo sapiens_hsa041140.61064699
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60684838
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.59495076
106Melanogenesis_Homo sapiens_hsa049160.58714869
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57810720
108HTLV-I infection_Homo sapiens_hsa051660.57696891
109Measles_Homo sapiens_hsa051620.56711675
110Arginine and proline metabolism_Homo sapiens_hsa003300.55784079
111Hedgehog signaling pathway_Homo sapiens_hsa043400.55457656
112Viral carcinogenesis_Homo sapiens_hsa052030.54836343
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54316831
114Hematopoietic cell lineage_Homo sapiens_hsa046400.54108926
115Oxytocin signaling pathway_Homo sapiens_hsa049210.51732529
116Apoptosis_Homo sapiens_hsa042100.51494317
117Calcium signaling pathway_Homo sapiens_hsa040200.51463343
118Inositol phosphate metabolism_Homo sapiens_hsa005620.51293644
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.50721622
120Salmonella infection_Homo sapiens_hsa051320.50245859
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49593473
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49196691
123Choline metabolism in cancer_Homo sapiens_hsa052310.48593337
124Endocytosis_Homo sapiens_hsa041440.47876490
125Hepatitis C_Homo sapiens_hsa051600.47620880
126Small cell lung cancer_Homo sapiens_hsa052220.47298412
127Biosynthesis of amino acids_Homo sapiens_hsa012300.45834818
128Salivary secretion_Homo sapiens_hsa049700.45274189
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45132693
130Hepatitis B_Homo sapiens_hsa051610.44798943
131Renal cell carcinoma_Homo sapiens_hsa052110.44436465
132AMPK signaling pathway_Homo sapiens_hsa041520.43901985
133Prolactin signaling pathway_Homo sapiens_hsa049170.43011391
134Insulin signaling pathway_Homo sapiens_hsa049100.41867397
135Alcoholism_Homo sapiens_hsa050340.41847422
136Pancreatic cancer_Homo sapiens_hsa052120.41735596
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41502449
138Colorectal cancer_Homo sapiens_hsa052100.41312312
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.39136685
140Ether lipid metabolism_Homo sapiens_hsa005650.36262310
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35297739
142Influenza A_Homo sapiens_hsa051640.34463745
143Long-term depression_Homo sapiens_hsa047300.31621063
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.30789220
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.30702400
146Pathways in cancer_Homo sapiens_hsa052000.27808614
147Chemokine signaling pathway_Homo sapiens_hsa040620.27060859
148Osteoclast differentiation_Homo sapiens_hsa043800.26145717
149Chronic myeloid leukemia_Homo sapiens_hsa052200.24540425
150NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22869236
151Toxoplasmosis_Homo sapiens_hsa051450.22142629
152Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21712445
153Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18987115
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18337044
155Ovarian steroidogenesis_Homo sapiens_hsa049130.17991408
156African trypanosomiasis_Homo sapiens_hsa051430.16506400
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15966048
158Intestinal immune network for IgA production_Homo sapiens_hsa046720.15816020
159Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15197804
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15085374

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