SHISA9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.81230252
2locomotory exploration behavior (GO:0035641)5.76771788
3* regulation of short-term neuronal synaptic plasticity (GO:0048172)5.50660233
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.34997341
5synaptic vesicle maturation (GO:0016188)5.29939319
6synaptic vesicle exocytosis (GO:0016079)5.26458560
7neuron cell-cell adhesion (GO:0007158)5.24215586
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.17176916
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.05251305
10regulation of glutamate receptor signaling pathway (GO:1900449)5.01041169
11gamma-aminobutyric acid transport (GO:0015812)4.94491331
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.80466614
13neurotransmitter secretion (GO:0007269)4.72034888
14exploration behavior (GO:0035640)4.71895614
15glutamate secretion (GO:0014047)4.71368654
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.71322985
17behavioral response to nicotine (GO:0035095)4.69049337
18kynurenine metabolic process (GO:0070189)4.65797566
19protein localization to synapse (GO:0035418)4.65176371
20indole-containing compound catabolic process (GO:0042436)4.59325098
21indolalkylamine catabolic process (GO:0046218)4.59325098
22tryptophan catabolic process (GO:0006569)4.59325098
23neurotransmitter-gated ion channel clustering (GO:0072578)4.53389233
24regulation of gene silencing by RNA (GO:0060966)4.45605216
25regulation of posttranscriptional gene silencing (GO:0060147)4.45605216
26regulation of gene silencing by miRNA (GO:0060964)4.45605216
27regulation of synaptic vesicle exocytosis (GO:2000300)4.45589817
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.40233880
29indolalkylamine metabolic process (GO:0006586)4.32991071
30glutamate receptor signaling pathway (GO:0007215)4.30555774
31regulation of synapse structural plasticity (GO:0051823)4.26928933
32neuronal action potential propagation (GO:0019227)4.19585626
33neuron-neuron synaptic transmission (GO:0007270)4.14680009
34synaptic transmission, glutamatergic (GO:0035249)4.11572079
35* regulation of neuronal synaptic plasticity (GO:0048168)4.09170115
36layer formation in cerebral cortex (GO:0021819)4.05226834
37serotonin metabolic process (GO:0042428)4.01917038
38proline transport (GO:0015824)3.99842468
39regulation of synaptic vesicle transport (GO:1902803)3.97932331
40long-term memory (GO:0007616)3.95454950
41cellular potassium ion homeostasis (GO:0030007)3.95428685
42tryptophan metabolic process (GO:0006568)3.92655599
43negative regulation of translation, ncRNA-mediated (GO:0040033)3.89944960
44regulation of translation, ncRNA-mediated (GO:0045974)3.89944960
45negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.89944960
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.89866676
47signal peptide processing (GO:0006465)3.88426615
48neurotransmitter transport (GO:0006836)3.87493870
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.82008446
50transmission of nerve impulse (GO:0019226)3.80188455
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.79938665
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.79853976
53response to histamine (GO:0034776)3.77541814
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.77462162
55indole-containing compound metabolic process (GO:0042430)3.76426812
56regulation of hippo signaling (GO:0035330)3.76417360
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.75442804
58positive regulation of synapse maturation (GO:0090129)3.73012102
59neuron recognition (GO:0008038)3.70284251
60regulation of neurotransmitter levels (GO:0001505)3.69591345
61primary amino compound metabolic process (GO:1901160)3.68069760
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.66945926
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.66640996
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.65794972
65sodium ion export (GO:0071436)3.64746651
66regulation of postsynaptic membrane potential (GO:0060078)3.60855368
67fucose catabolic process (GO:0019317)3.60652865
68L-fucose metabolic process (GO:0042354)3.60652865
69L-fucose catabolic process (GO:0042355)3.60652865
70dendritic spine morphogenesis (GO:0060997)3.59482088
71positive regulation of membrane potential (GO:0045838)3.59005521
72gamma-aminobutyric acid signaling pathway (GO:0007214)3.58723495
73postsynaptic membrane organization (GO:0001941)3.54448546
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.51795721
75neuronal action potential (GO:0019228)3.49266282
76sulfation (GO:0051923)3.47958826
77prepulse inhibition (GO:0060134)3.47051213
78positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46655177
79long-term synaptic potentiation (GO:0060291)3.43979555
80regulation of pigment cell differentiation (GO:0050932)3.43592454
81reflex (GO:0060004)3.42871168
82startle response (GO:0001964)3.40760010
83presynaptic membrane assembly (GO:0097105)3.38939592
84positive regulation of developmental pigmentation (GO:0048087)3.37599294
85* regulation of synaptic plasticity (GO:0048167)3.35863287
86detection of light stimulus involved in visual perception (GO:0050908)3.35483890
87detection of light stimulus involved in sensory perception (GO:0050962)3.35483890
88auditory behavior (GO:0031223)3.34862687
89membrane depolarization during action potential (GO:0086010)3.34777026
90regulation of vesicle fusion (GO:0031338)3.32466081
91synapse assembly (GO:0007416)3.31648566
92response to auditory stimulus (GO:0010996)3.28252027
93regulation of sarcomere organization (GO:0060297)3.28129274
94cell communication by electrical coupling (GO:0010644)3.26795362
95axonal fasciculation (GO:0007413)3.25197763
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.24684037
97cerebellar Purkinje cell differentiation (GO:0021702)3.24215337
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.23954656
99negative regulation of cytosolic calcium ion concentration (GO:0051481)3.23792293
100regulation of dendritic spine morphogenesis (GO:0061001)3.22982939
101monoubiquitinated protein deubiquitination (GO:0035520)3.22580486
102learning (GO:0007612)3.19974665
103protein K48-linked deubiquitination (GO:0071108)3.19331309
104behavioral fear response (GO:0001662)3.18285544
105behavioral defense response (GO:0002209)3.18285544
106negative regulation of sodium ion transport (GO:0010766)3.17783698
107behavioral response to ethanol (GO:0048149)3.17579033
108regulation of neurotransmitter secretion (GO:0046928)3.15215935
109striatum development (GO:0021756)3.14855016
110regulation of establishment of cell polarity (GO:2000114)3.14123657
111activation of protein kinase A activity (GO:0034199)3.13877159
112membrane hyperpolarization (GO:0060081)3.12535958
113neural tube formation (GO:0001841)3.11586968
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11300761
115cilium or flagellum-dependent cell motility (GO:0001539)3.11161466
116NAD biosynthetic process (GO:0009435)3.10660285
117neuromuscular process controlling balance (GO:0050885)3.10010100
118fear response (GO:0042596)3.10009947
119neuronal ion channel clustering (GO:0045161)3.09792300
120flavonoid metabolic process (GO:0009812)3.09131502
121interkinetic nuclear migration (GO:0022027)3.08828279
122neuromuscular process controlling posture (GO:0050884)3.08161196
123membrane depolarization (GO:0051899)3.06268819
124oxidative demethylation (GO:0070989)3.06194695
125behavioral response to cocaine (GO:0048148)3.06185858
126cerebellar granule cell differentiation (GO:0021707)3.04750728
127snRNA transcription (GO:0009301)3.04650899
128presynaptic membrane organization (GO:0097090)3.04428661
129dendrite morphogenesis (GO:0048813)3.04384922
130regulation of synaptic transmission, GABAergic (GO:0032228)3.03100475
131mating behavior (GO:0007617)3.02690484
132regulation of neurotransmitter transport (GO:0051588)3.00939411
133social behavior (GO:0035176)3.00301786
134intraspecies interaction between organisms (GO:0051703)3.00301786
135positive regulation of synaptic transmission (GO:0050806)2.99665232
136negative regulation of systemic arterial blood pressure (GO:0003085)2.99431274
137synaptic transmission (GO:0007268)2.98034810
138regulation of synapse maturation (GO:0090128)2.97855974
139synaptic transmission, dopaminergic (GO:0001963)2.97749115
140positive regulation of neurotransmitter transport (GO:0051590)2.97645930
141synaptic vesicle endocytosis (GO:0048488)2.97465326
142regulation of glutamate secretion (GO:0014048)2.95836259
143G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.95533107
144regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93870236
145glycine transport (GO:0015816)2.93715679
146cellular ketone body metabolic process (GO:0046950)2.88885708
147establishment of protein localization to Golgi (GO:0072600)2.87147087
148regulation of establishment or maintenance of cell polarity (GO:0032878)2.79285195
149photoreceptor cell maintenance (GO:0045494)2.77488325
150epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.76871740
151detection of mechanical stimulus involved in sensory perception (GO:0050974)2.76070810
152negative regulation of protein localization to cell surface (GO:2000009)2.74804577
153retinal cone cell development (GO:0046549)2.72818918
154limb development (GO:0060173)2.72666082
155appendage development (GO:0048736)2.72666082
156protein K11-linked deubiquitination (GO:0035871)2.71849435
157amine catabolic process (GO:0009310)2.70118471
158cellular biogenic amine catabolic process (GO:0042402)2.70118471
159thyroid hormone metabolic process (GO:0042403)2.66975872
160spinal cord motor neuron differentiation (GO:0021522)2.66397597
161peristalsis (GO:0030432)2.64537262
162cardiovascular system development (GO:0072358)2.64345163
163lipid translocation (GO:0034204)2.61246059
164phospholipid translocation (GO:0045332)2.61246059
165protein K63-linked deubiquitination (GO:0070536)2.60806100
166endosome to pigment granule transport (GO:0043485)2.59799638
167endosome to melanosome transport (GO:0035646)2.59799638
168kidney morphogenesis (GO:0060993)2.58243403
169cellular response to sterol (GO:0036315)2.56963391
170ketone body metabolic process (GO:1902224)2.54641405
171potassium ion transmembrane transport (GO:0071805)2.54553164
172cellular potassium ion transport (GO:0071804)2.54553164
173regulation of collateral sprouting (GO:0048670)2.53854805
174cAMP catabolic process (GO:0006198)2.53422597
175benzene-containing compound metabolic process (GO:0042537)2.49355843
176central nervous system neuron axonogenesis (GO:0021955)2.47669853
177nonmotile primary cilium assembly (GO:0035058)2.47239913
178action potential (GO:0001508)2.47069351
179response to pheromone (GO:0019236)2.46705809
180axon ensheathment in central nervous system (GO:0032291)2.44130112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.20422541
2GBX2_23144817_ChIP-Seq_PC3_Human3.67624420
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18709864
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14317313
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07546676
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68068364
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68068364
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67871878
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64555540
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58903682
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56002068
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.55757303
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51207107
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.47127958
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46109208
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.35436671
17DROSHA_22980978_ChIP-Seq_HELA_Human2.32667689
18* RARB_27405468_Chip-Seq_BRAIN_Mouse2.32253908
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25496254
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23614122
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20183820
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18857282
23AR_21572438_ChIP-Seq_LNCaP_Human2.18588276
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.14502406
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.11557034
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.08673178
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05623947
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01383380
29* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94885087
30EWS_26573619_Chip-Seq_HEK293_Human1.94149998
31TAF15_26573619_Chip-Seq_HEK293_Human1.92527563
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.89865713
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.79790886
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77793786
35* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76475434
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72913451
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72502353
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.70959320
39* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61512206
40* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56265276
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54157127
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53854112
43P300_19829295_ChIP-Seq_ESCs_Human1.51792949
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48096724
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.47651673
46ZNF274_21170338_ChIP-Seq_K562_Hela1.47191257
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45306099
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.44675368
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43176043
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.42587426
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.42296260
52CBP_20019798_ChIP-Seq_JUKART_Human1.39576063
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39576063
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.38401076
55AR_25329375_ChIP-Seq_VCAP_Human1.38296776
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37363206
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37242035
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.36668253
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35804555
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33058060
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30283790
62TCF4_22108803_ChIP-Seq_LS180_Human1.29144197
63IGF1R_20145208_ChIP-Seq_DFB_Human1.29127208
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.28605389
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28526176
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.28393421
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28057013
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27840159
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27043310
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25988685
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25132389
72STAT3_23295773_ChIP-Seq_U87_Human1.25129762
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23645941
74* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22889189
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.21554018
76* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21332478
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21032404
78FUS_26573619_Chip-Seq_HEK293_Human1.20176863
79AR_19668381_ChIP-Seq_PC3_Human1.18227038
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.16609419
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16257284
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.15802943
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15797555
84* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15076929
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14381943
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13899787
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.13485507
88* KDM2B_26808549_Chip-Seq_REH_Human1.12790995
89* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12313854
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11999688
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11410916
92SOX2_19829295_ChIP-Seq_ESCs_Human1.10790291
93NANOG_19829295_ChIP-Seq_ESCs_Human1.10790291
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10482455
95IRF1_19129219_ChIP-ChIP_H3396_Human1.09916652
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09728284
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09671772
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09570396
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.09021503
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08421101
101TCF4_23295773_ChIP-Seq_U87_Human1.08212575
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08025008
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07714358
104RNF2_27304074_Chip-Seq_NSC_Mouse1.07668863
105* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07580263
106BCAT_22108803_ChIP-Seq_LS180_Human1.06904680
107RUNX2_22187159_ChIP-Seq_PCA_Human1.05089283
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.04827778
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04362948
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04277874
111DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04257926
112P53_22387025_ChIP-Seq_ESCs_Mouse1.04169916
113P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01308339
114* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00857342
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.00227842
116TP53_18474530_ChIP-ChIP_U2OS_Human1.00196145
117* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99998272
118CRX_20693478_ChIP-Seq_RETINA_Mouse0.99785930
119AHR_22903824_ChIP-Seq_MCF-7_Human0.99205989
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.98625340
121ER_23166858_ChIP-Seq_MCF-7_Human0.98262940
122TP53_16413492_ChIP-PET_HCT116_Human0.97482614
123* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96939158
124RXR_22108803_ChIP-Seq_LS180_Human0.96458613
125JUN_21703547_ChIP-Seq_K562_Human0.95204622
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93559438
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93559438
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.91073355
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.88311359
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88134209
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87812718
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87511805
133VDR_22108803_ChIP-Seq_LS180_Human0.87511295
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87188478
135* SMAD3_21741376_ChIP-Seq_ESCs_Human0.86661278
136TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86128833
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85295530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.82705285
2MP0003880_abnormal_central_pattern4.67488553
3MP0003635_abnormal_synaptic_transmissio4.14732386
4MP0002822_catalepsy4.14315824
5MP0009745_abnormal_behavioral_response3.61716211
6MP0002063_abnormal_learning/memory/cond3.31890412
7MP0004270_analgesia3.28532685
8MP0009046_muscle_twitch3.27947788
9MP0002064_seizures3.26761248
10MP0005423_abnormal_somatic_nervous3.15452899
11MP0003195_calcinosis3.14202667
12MP0002572_abnormal_emotion/affect_behav2.99184430
13MP0001968_abnormal_touch/_nociception2.80610309
14MP0001486_abnormal_startle_reflex2.63254167
15MP0001501_abnormal_sleep_pattern2.60886624
16MP0003646_muscle_fatigue2.60152285
17MP0002272_abnormal_nervous_system2.57990417
18MP0002734_abnormal_mechanical_nocicepti2.46790259
19MP0001440_abnormal_grooming_behavior2.35591441
20MP0004043_abnormal_pH_regulation2.29376307
21MP0008877_abnormal_DNA_methylation2.25246444
22MP0008057_abnormal_DNA_replication2.22219462
23MP0005646_abnormal_pituitary_gland2.12375714
24MP0009780_abnormal_chondrocyte_physiolo2.10614613
25MP0002735_abnormal_chemical_nociception2.07346314
26MP0002736_abnormal_nociception_after2.06940041
27MP0002733_abnormal_thermal_nociception2.05387504
28MP0003329_amyloid_beta_deposits2.00662934
29MP0002067_abnormal_sensory_capabilities1.97109756
30MP0005386_behavior/neurological_phenoty1.96609059
31MP0004924_abnormal_behavior1.96609059
32MP0006276_abnormal_autonomic_nervous1.93662211
33MP0001970_abnormal_pain_threshold1.93491781
34MP0002557_abnormal_social/conspecific_i1.89635451
35MP0004858_abnormal_nervous_system1.86520735
36MP0008569_lethality_at_weaning1.78131124
37MP0003136_yellow_coat_color1.77597129
38MP0001984_abnormal_olfaction1.73555985
39MP0000427_abnormal_hair_cycle1.72257224
40MP0002184_abnormal_innervation1.71194039
41MP0001529_abnormal_vocalization1.67495868
42MP0002909_abnormal_adrenal_gland1.66243055
43MP0000778_abnormal_nervous_system1.60555796
44MP0004885_abnormal_endolymph1.57019240
45MP0001905_abnormal_dopamine_level1.54235790
46MP0002102_abnormal_ear_morphology1.51402939
47MP0003890_abnormal_embryonic-extraembry1.51171295
48MP0004811_abnormal_neuron_physiology1.49670300
49MP0004133_heterotaxia1.46050818
50MP0006292_abnormal_olfactory_placode1.43654237
51MP0000955_abnormal_spinal_cord1.40588729
52MP0001188_hyperpigmentation1.40117701
53MP0002066_abnormal_motor_capabilities/c1.38130996
54MP0005253_abnormal_eye_physiology1.37232890
55MP0005645_abnormal_hypothalamus_physiol1.36006262
56MP0003879_abnormal_hair_cell1.35824351
57MP0004142_abnormal_muscle_tone1.35792603
58MP0002882_abnormal_neuron_morphology1.33719528
59MP0003633_abnormal_nervous_system1.24766761
60MP0003122_maternal_imprinting1.24402573
61MP0001502_abnormal_circadian_rhythm1.23572875
62MP0003787_abnormal_imprinting1.23169772
63MP0004147_increased_porphyrin_level1.21789615
64MP0000383_abnormal_hair_follicle1.21736410
65MP0005174_abnormal_tail_pigmentation1.19808816
66MP0002938_white_spotting1.17036789
67MP0003119_abnormal_digestive_system1.16105915
68MP0001986_abnormal_taste_sensitivity1.14992851
69MP0004130_abnormal_muscle_cell1.14143673
70MP0008872_abnormal_physiological_respon1.12920772
71MP0002653_abnormal_ependyma_morphology1.12721905
72MP0003631_nervous_system_phenotype1.09973077
73MP0003690_abnormal_glial_cell1.09761435
74MP0002152_abnormal_brain_morphology1.04815239
75MP0006072_abnormal_retinal_apoptosis1.03381633
76MP0005551_abnormal_eye_electrophysiolog0.99100318
77MP0002928_abnormal_bile_duct0.96918224
78MP0010386_abnormal_urinary_bladder0.96590447
79MP0008874_decreased_physiological_sensi0.95515956
80MP0000751_myopathy0.94788469
81MP0001177_atelectasis0.94505225
82MP0003878_abnormal_ear_physiology0.93845274
83MP0005377_hearing/vestibular/ear_phenot0.93845274
84MP0000604_amyloidosis0.93611796
85MP0005195_abnormal_posterior_eye0.93339214
86MP0004085_abnormal_heartbeat0.91981970
87MP0003937_abnormal_limbs/digits/tail_de0.91288737
88MP0002638_abnormal_pupillary_reflex0.90915582
89MP0000230_abnormal_systemic_arterial0.90052325
90MP0002069_abnormal_eating/drinking_beha0.89550970
91MP0003634_abnormal_glial_cell0.88441226
92MP0002229_neurodegeneration0.87683362
93MP0005535_abnormal_body_temperature0.87266741
94MP0005409_darkened_coat_color0.86812577
95MP0003632_abnormal_nervous_system0.85676835
96MP0004742_abnormal_vestibular_system0.85652877
97MP0004215_abnormal_myocardial_fiber0.84436188
98MP0000013_abnormal_adipose_tissue0.83515657
99MP0005266_abnormal_metabolism0.82676003
100MP0002138_abnormal_hepatobiliary_system0.81211097
101MP0002876_abnormal_thyroid_physiology0.80776662
102MP0000538_abnormal_urinary_bladder0.79542461
103MP0003698_abnormal_male_reproductive0.78955266
104MP0003075_altered_response_to0.78793706
105MP0003718_maternal_effect0.78661463
106MP0001963_abnormal_hearing_physiology0.78123321
107MP0002090_abnormal_vision0.77861198
108MP0000631_abnormal_neuroendocrine_gland0.77562487
109MP0003045_fibrosis0.74911217
110MP0005448_abnormal_energy_balance0.73522519
111MP0000372_irregular_coat_pigmentation0.73520755
112MP0005310_abnormal_salivary_gland0.73253850
113MP0002751_abnormal_autonomic_nervous0.72307709
114MP0003252_abnormal_bile_duct0.71874447
115MP0005171_absent_coat_pigmentation0.70326504
116MP0002752_abnormal_somatic_nervous0.70214884
117MP0000569_abnormal_digit_pigmentation0.69749145
118MP0004145_abnormal_muscle_electrophysio0.66945500
119MP0003137_abnormal_impulse_conducting0.66717192
120MP0000920_abnormal_myelination0.64286768
121MP0005394_taste/olfaction_phenotype0.63824701
122MP0005499_abnormal_olfactory_system0.63824701
123MP0002837_dystrophic_cardiac_calcinosis0.62621682
124MP0001299_abnormal_eye_distance/0.59953156
125MP0001943_abnormal_respiration0.59519590
126MP0005167_abnormal_blood-brain_barrier0.58944894
127MP0001664_abnormal_digestion0.58250940
128MP0005623_abnormal_meninges_morphology0.56768656
129MP0004484_altered_response_of0.56189359
130MP0004233_abnormal_muscle_weight0.55199239
131MP0001485_abnormal_pinna_reflex0.54364117
132MP0010770_preweaning_lethality0.50800511
133MP0002082_postnatal_lethality0.50800511
134MP0010769_abnormal_survival0.50741445
135MP0008961_abnormal_basal_metabolism0.50084439
136MP0000026_abnormal_inner_ear0.49514994
137MP0003861_abnormal_nervous_system0.47572358
138MP0010768_mortality/aging0.46972717

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.38502347
2Myokymia (HP:0002411)6.14454622
3Focal seizures (HP:0007359)6.03486428
4Epileptic encephalopathy (HP:0200134)4.90995193
5Visual hallucinations (HP:0002367)4.87956119
6Atonic seizures (HP:0010819)4.86624227
7Pancreatic cysts (HP:0001737)4.62496581
8Febrile seizures (HP:0002373)4.62163273
9Absence seizures (HP:0002121)4.32505506
10Generalized tonic-clonic seizures (HP:0002069)4.16313173
11Pancreatic fibrosis (HP:0100732)4.10321587
12Progressive cerebellar ataxia (HP:0002073)4.08697970
13Dialeptic seizures (HP:0011146)4.05067299
14Hyperventilation (HP:0002883)4.02594614
15True hermaphroditism (HP:0010459)3.96276977
16Broad-based gait (HP:0002136)3.54371955
17Abnormality of midbrain morphology (HP:0002418)3.44137039
18Molar tooth sign on MRI (HP:0002419)3.44137039
19Supranuclear gaze palsy (HP:0000605)3.41609331
20Congenital stationary night blindness (HP:0007642)3.39602457
21Diplopia (HP:0000651)3.37481944
22Abnormality of binocular vision (HP:0011514)3.37481944
23Poor eye contact (HP:0000817)3.37351817
24Action tremor (HP:0002345)3.36720911
25Progressive inability to walk (HP:0002505)3.30248875
26Impaired social interactions (HP:0000735)3.25021709
27Abnormal social behavior (HP:0012433)3.25021709
28Dysdiadochokinesis (HP:0002075)3.22699514
29Neurofibrillary tangles (HP:0002185)3.19121531
30Cystic liver disease (HP:0006706)3.17920523
31Nephronophthisis (HP:0000090)3.16150479
32Hemiparesis (HP:0001269)3.11413966
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.08574906
34Anxiety (HP:0000739)3.03363715
35Depression (HP:0000716)3.03164909
36Gaze-evoked nystagmus (HP:0000640)3.02622497
37Truncal ataxia (HP:0002078)3.02590564
38Ankle clonus (HP:0011448)3.02114623
39Postural instability (HP:0002172)3.02040381
40Cerebral inclusion bodies (HP:0100314)3.01014799
41Attenuation of retinal blood vessels (HP:0007843)3.00973906
42Abnormal eating behavior (HP:0100738)2.95683713
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.89891643
44Impaired vibration sensation in the lower limbs (HP:0002166)2.88269093
45Limb dystonia (HP:0002451)2.87109148
46Abnormality of the renal medulla (HP:0100957)2.85673295
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.85565181
48Abnormality of alanine metabolism (HP:0010916)2.85565181
49Hyperalaninemia (HP:0003348)2.85565181
50Dysmetria (HP:0001310)2.83774970
51Medial flaring of the eyebrow (HP:0010747)2.83109866
52Mutism (HP:0002300)2.80665124
53Hemiplegia (HP:0002301)2.79477420
54Abnormality of the renal cortex (HP:0011035)2.78337724
55Abolished electroretinogram (ERG) (HP:0000550)2.75869561
56Amblyopia (HP:0000646)2.74907203
57Excessive salivation (HP:0003781)2.72812305
58Drooling (HP:0002307)2.72812305
59Urinary bladder sphincter dysfunction (HP:0002839)2.71900876
60Papilledema (HP:0001085)2.69684951
61Aplasia involving bones of the extremities (HP:0009825)2.68765445
62Aplasia involving bones of the upper limbs (HP:0009823)2.68765445
63Aplasia of the phalanges of the hand (HP:0009802)2.68765445
64Genetic anticipation (HP:0003743)2.66504690
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.66337483
66Absent speech (HP:0001344)2.65788481
67Fair hair (HP:0002286)2.65512982
68Chronic hepatic failure (HP:0100626)2.64266001
69Furrowed tongue (HP:0000221)2.53308348
70Polyphagia (HP:0002591)2.50297536
71Status epilepticus (HP:0002133)2.49100927
72Sclerocornea (HP:0000647)2.48975391
73Bradykinesia (HP:0002067)2.48524040
74Tubular atrophy (HP:0000092)2.45546012
75Inability to walk (HP:0002540)2.45270423
76Epileptiform EEG discharges (HP:0011182)2.42658003
77Type II lissencephaly (HP:0007260)2.42093968
78Torticollis (HP:0000473)2.41670836
79Hypoplastic ischia (HP:0003175)2.38867233
80Stereotypic behavior (HP:0000733)2.36666540
81Blue irides (HP:0000635)2.36181560
82Aplasia/Hypoplasia of the tongue (HP:0010295)2.35258255
83Scanning speech (HP:0002168)2.34969247
84EEG with generalized epileptiform discharges (HP:0011198)2.33772499
85Patellar aplasia (HP:0006443)2.32110322
86Genital tract atresia (HP:0001827)2.30801065
87Congenital primary aphakia (HP:0007707)2.30052411
88Megalencephaly (HP:0001355)2.27304555
89Vaginal atresia (HP:0000148)2.27033017
90Impaired smooth pursuit (HP:0007772)2.26197378
91Large for gestational age (HP:0001520)2.25298806
92Hypsarrhythmia (HP:0002521)2.24734898
93Birth length less than 3rd percentile (HP:0003561)2.24389165
94Spastic gait (HP:0002064)2.20535425
95Focal dystonia (HP:0004373)2.20383369
96Anencephaly (HP:0002323)2.18859446
97Bony spicule pigmentary retinopathy (HP:0007737)2.17494583
98Generalized myoclonic seizures (HP:0002123)2.16854141
99Urinary urgency (HP:0000012)2.16557236
100Abnormality of the ischium (HP:0003174)2.16539264
101Pendular nystagmus (HP:0012043)2.15166898
102Aplasia/Hypoplasia of the patella (HP:0006498)2.13414079
103Lissencephaly (HP:0001339)2.12895035
104Preaxial foot polydactyly (HP:0001841)2.11951900
105Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11681205
106Congenital sensorineural hearing impairment (HP:0008527)2.10601466
107Polydipsia (HP:0001959)2.10316286
108Abnormal drinking behavior (HP:0030082)2.10316286
109Keratoconus (HP:0000563)2.09970506
110Increased corneal curvature (HP:0100692)2.09970506
111Decreased circulating renin level (HP:0003351)2.09781357
112Congenital hepatic fibrosis (HP:0002612)2.08941122
113Fetal akinesia sequence (HP:0001989)2.08697812
114Pheochromocytoma (HP:0002666)2.08425778
115Dynein arm defect of respiratory motile cilia (HP:0012255)2.08409917
116Absent/shortened dynein arms (HP:0200106)2.08409917
117Nephrogenic diabetes insipidus (HP:0009806)2.08173905
118Intention tremor (HP:0002080)2.07702225
119Gait imbalance (HP:0002141)2.07252467
120Lower limb muscle weakness (HP:0007340)2.06346424
121Abnormality of ocular smooth pursuit (HP:0000617)2.05910432
122Stomach cancer (HP:0012126)2.05798915
123Generalized hypopigmentation of hair (HP:0011358)2.05438120
124Congenital, generalized hypertrichosis (HP:0004540)2.03502915
125Agitation (HP:0000713)2.00961599
126Abnormality of the corticospinal tract (HP:0002492)2.00716461
127Cerebellar dysplasia (HP:0007033)2.00236354
128Chorioretinal atrophy (HP:0000533)1.97725797
129Craniofacial dystonia (HP:0012179)1.97550238
130Widely spaced teeth (HP:0000687)1.97016577
131Hypoplasia of the pons (HP:0012110)1.96792712
132Hypoventilation (HP:0002791)1.96215991
133Dysmetric saccades (HP:0000641)1.94719655
134Decreased central vision (HP:0007663)1.94299515
135Poor coordination (HP:0002370)1.94081048
136Small hand (HP:0200055)1.91841397
137Gait ataxia (HP:0002066)1.91788854
138Hyperthyroidism (HP:0000836)1.91681283
139Optic nerve hypoplasia (HP:0000609)1.91659038
140Abnormality of the pons (HP:0007361)1.91144883
141Rigidity (HP:0002063)1.90723880
142Clumsiness (HP:0002312)1.90381113
143Impaired vibratory sensation (HP:0002495)1.88790840
144Protruding tongue (HP:0010808)1.88517080
145Psychosis (HP:0000709)1.88192652
146Neuroendocrine neoplasm (HP:0100634)1.87931443
147Specific learning disability (HP:0001328)1.87748423
148Abnormality of salivation (HP:0100755)1.87540078
149Abnormality of the pubic bones (HP:0003172)1.86299514
150Increased cerebral lipofuscin (HP:0011813)1.85178995
151Insidious onset (HP:0003587)1.83576608
152Termporal pattern (HP:0011008)1.83576608
153Neuronal loss in central nervous system (HP:0002529)1.81818691
154Inappropriate behavior (HP:0000719)1.81384935
155Male pseudohermaphroditism (HP:0000037)1.80879798
156Short foot (HP:0001773)1.80643681
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80635702
158Preaxial hand polydactyly (HP:0001177)1.79625557
159Resting tremor (HP:0002322)1.79586845
160Incomplete penetrance (HP:0003829)1.78806067
161Abnormality of the lower motor neuron (HP:0002366)1.77828594
162Hypoplastic labia majora (HP:0000059)1.76823596
163Postaxial foot polydactyly (HP:0001830)1.76566406
164Abnormal ciliary motility (HP:0012262)1.75185985
165Annular pancreas (HP:0001734)1.74967633
166Thickened helices (HP:0000391)1.74626013
167Narrow nasal bridge (HP:0000446)1.73938282
168Abnormal EKG (HP:0003115)1.73810232
169Macroglossia (HP:0000158)1.73505001
170Amyotrophic lateral sclerosis (HP:0007354)1.72781524
171Ventricular fibrillation (HP:0001663)1.72703903
172Humeroradial synostosis (HP:0003041)1.72417394
173Synostosis involving the elbow (HP:0003938)1.72417394
174Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71569718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.43114674
2NTRK34.92478632
3EPHA44.47011722
4MAP3K93.48768797
5ACVR1B3.23303551
6BMPR1B3.14614812
7MARK13.06101265
8MAP3K42.92713573
9ADRBK22.83067161
10MAP2K72.62701627
11NTRK22.62701618
12TNIK2.48741720
13MINK12.46039286
14INSRR2.45608900
15CASK2.31623564
16NTRK12.23834900
17DAPK22.02849075
18PNCK1.92733833
19PAK61.90361280
20KSR21.90218704
21MKNK21.89793525
22GRK11.86064770
23ZAK1.82368389
24MAP2K41.75014434
25MAP3K121.74155910
26NUAK11.63313487
27FES1.59478985
28RIPK41.52184742
29CDK51.51617023
30CAMKK11.46095972
31KSR11.45463440
32MAPK131.44740103
33GRK51.44506150
34SIK21.42298402
35TAOK31.40362283
36PRKCG1.39887345
37PRKD31.39595122
38PLK21.38950777
39TLK11.30425767
40MAP3K21.26359231
41DAPK11.23253419
42PHKG11.22305441
43PHKG21.22305441
44WNK41.20612886
45STK38L1.16823926
46CAMK2A1.13840590
47ARAF1.12564762
48STK391.11417908
49TYRO31.08353273
50CAMKK21.08208264
51STK381.04616150
52CDK191.03423943
53PRPF4B1.03323676
54AKT31.02691348
55MUSK1.02604552
56MAP4K21.02376114
57TGFBR11.01196885
58MAP3K130.99553432
59UHMK10.96820294
60CAMK10.95103459
61CSNK1G20.92244465
62LATS20.88350827
63LATS10.87903171
64SGK4940.85159930
65SGK2230.85159930
66PRKCE0.85122873
67CDK180.83690037
68CDK140.83115569
69CDK150.82867345
70PIK3CA0.82245211
71SGK20.81102628
72CAMK2B0.80505072
73CAMK1D0.79589027
74TNK20.77121211
75BRSK20.74941101
76PAK30.74592552
77PRKCH0.74527963
78SGK10.74186022
79STK110.73986671
80STK30.73722707
81LMTK20.72257153
82RAF10.71358729
83CDK11A0.71291582
84MKNK10.70704465
85MARK20.69756190
86CAMK1G0.68197350
87DYRK1A0.67912697
88MAPK120.67080937
89TAOK10.63777027
90RET0.62252100
91BMPR20.61061844
92TEC0.60705481
93OXSR10.60566297
94NEK60.60217166
95SGK30.59968359
96PINK10.58668376
97ERBB40.58608599
98PIK3CG0.58227788
99MAPKAPK30.57427158
100WNK30.57011180
101TXK0.55062340
102PTK2B0.54898517
103NLK0.53950565
104ALK0.53231949
105ERBB20.53159106
106TRPM70.52750615
107CAMK2D0.52647958
108CAMK2G0.52411702
109FYN0.52070418
110FGR0.52045420
111MAP2K10.51986617
112RPS6KA30.51419637
113PRKAA20.50989364
114CHUK0.49310414
115PRKCZ0.49089270
116MAP3K60.48803148
117CHEK20.48281127
118MAP3K10.47579125
119NEK20.47034297
120MELK0.46165228
121GRK70.45566917
122IRAK10.44463932
123OBSCN0.44437661
124WEE10.44078349
125FGFR20.43423400
126FER0.43375322
127CSNK1D0.43305403
128PDK10.42932478
129PKN10.42638642
130PDPK10.42341598
131MAPKAPK50.42130323
132DYRK20.41290239
133MAPK100.41053711
134CAMK40.39670985
135PRKAA10.39236339
136PRKCB0.37671672
137ADRBK10.37310687
138PLK40.35210587
139CDC42BPA0.34901946
140CSNK1A1L0.34743765
141PRKACA0.34578130
142CDK30.34510011
143PRKCA0.34069606
144MAP3K70.33612834
145SCYL20.33225651
146WNK10.32348029
147TAF10.31732038
148CSNK1G10.31495051
149PRKG10.31337992
150CSNK1A10.31244982
151PRKCQ0.30575148

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98712862
2Synaptic vesicle cycle_Homo sapiens_hsa047213.16562027
3GABAergic synapse_Homo sapiens_hsa047273.03363675
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76378654
5Olfactory transduction_Homo sapiens_hsa047402.66006115
6Morphine addiction_Homo sapiens_hsa050322.64427899
7Circadian entrainment_Homo sapiens_hsa047132.63686721
8Glutamatergic synapse_Homo sapiens_hsa047242.61346259
9Long-term potentiation_Homo sapiens_hsa047202.46697648
10Amphetamine addiction_Homo sapiens_hsa050312.42221348
11Linoleic acid metabolism_Homo sapiens_hsa005912.21789200
12Salivary secretion_Homo sapiens_hsa049702.17229519
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16683137
14Dopaminergic synapse_Homo sapiens_hsa047282.13107157
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09745026
16Tryptophan metabolism_Homo sapiens_hsa003802.07873838
17Cocaine addiction_Homo sapiens_hsa050301.98285587
18Serotonergic synapse_Homo sapiens_hsa047261.92971502
19Insulin secretion_Homo sapiens_hsa049111.92946382
20Cholinergic synapse_Homo sapiens_hsa047251.91566873
21Taste transduction_Homo sapiens_hsa047421.86045042
22Gastric acid secretion_Homo sapiens_hsa049711.80111438
23Long-term depression_Homo sapiens_hsa047301.78901595
24Selenocompound metabolism_Homo sapiens_hsa004501.75000110
25Renin secretion_Homo sapiens_hsa049241.70579220
26ABC transporters_Homo sapiens_hsa020101.69227543
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65958482
28Homologous recombination_Homo sapiens_hsa034401.63379325
29Calcium signaling pathway_Homo sapiens_hsa040201.59884820
30Ether lipid metabolism_Homo sapiens_hsa005651.58643249
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54765570
32Collecting duct acid secretion_Homo sapiens_hsa049661.53129552
33Oxytocin signaling pathway_Homo sapiens_hsa049211.52786289
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47820246
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.42221265
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.37673615
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37150246
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34748571
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.34709655
40Gap junction_Homo sapiens_hsa045401.34303875
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33894109
42GnRH signaling pathway_Homo sapiens_hsa049121.33654346
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31453806
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30651481
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29450798
46cAMP signaling pathway_Homo sapiens_hsa040241.26680919
47Fanconi anemia pathway_Homo sapiens_hsa034601.24766897
48Histidine metabolism_Homo sapiens_hsa003401.24489665
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22056606
50Nitrogen metabolism_Homo sapiens_hsa009101.20758089
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15206999
52Cardiac muscle contraction_Homo sapiens_hsa042601.08281059
53Caffeine metabolism_Homo sapiens_hsa002321.06932701
54Estrogen signaling pathway_Homo sapiens_hsa049151.06779556
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05427964
56Axon guidance_Homo sapiens_hsa043601.05204039
57Melanogenesis_Homo sapiens_hsa049161.02122083
58Chemical carcinogenesis_Homo sapiens_hsa052041.00663237
59Retinol metabolism_Homo sapiens_hsa008300.99943200
60Glycerolipid metabolism_Homo sapiens_hsa005610.99254452
61Type II diabetes mellitus_Homo sapiens_hsa049300.95858272
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94703829
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94316984
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93743569
65Dorso-ventral axis formation_Homo sapiens_hsa043200.93584278
66Vibrio cholerae infection_Homo sapiens_hsa051100.90728679
67Glioma_Homo sapiens_hsa052140.90602991
68ErbB signaling pathway_Homo sapiens_hsa040120.90397420
69Type I diabetes mellitus_Homo sapiens_hsa049400.88200683
70Lysine degradation_Homo sapiens_hsa003100.87125895
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.87086948
72beta-Alanine metabolism_Homo sapiens_hsa004100.83292581
73Pancreatic secretion_Homo sapiens_hsa049720.83051173
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.81940703
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80176786
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79802124
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77988336
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77854632
79Thyroid hormone synthesis_Homo sapiens_hsa049180.77360044
80Phototransduction_Homo sapiens_hsa047440.75697979
81Dilated cardiomyopathy_Homo sapiens_hsa054140.75063612
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72997211
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72827167
84Propanoate metabolism_Homo sapiens_hsa006400.68540642
85Arachidonic acid metabolism_Homo sapiens_hsa005900.68413520
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67883991
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66956013
88Basal transcription factors_Homo sapiens_hsa030220.66846062
89Choline metabolism in cancer_Homo sapiens_hsa052310.65919606
90Oocyte meiosis_Homo sapiens_hsa041140.65847856
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.65281953
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63102463
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62837333
94MAPK signaling pathway_Homo sapiens_hsa040100.61845191
95Bile secretion_Homo sapiens_hsa049760.61639776
96Butanoate metabolism_Homo sapiens_hsa006500.60540872
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57715551
98Alcoholism_Homo sapiens_hsa050340.56680360
99RNA polymerase_Homo sapiens_hsa030200.56375141
100Ras signaling pathway_Homo sapiens_hsa040140.54749162
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51937586
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51438101
103Rap1 signaling pathway_Homo sapiens_hsa040150.50828882
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50590829
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49374481
106Alzheimers disease_Homo sapiens_hsa050100.49263070
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48431318
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48183134
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.47333029
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46563508
111Prion diseases_Homo sapiens_hsa050200.46034245
112Glucagon signaling pathway_Homo sapiens_hsa049220.45757973
113One carbon pool by folate_Homo sapiens_hsa006700.45241133
114African trypanosomiasis_Homo sapiens_hsa051430.45183609
115Ovarian steroidogenesis_Homo sapiens_hsa049130.43394220
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.42714890
117Fatty acid biosynthesis_Homo sapiens_hsa000610.42554600
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42353029
119Inositol phosphate metabolism_Homo sapiens_hsa005620.42185070
120Sphingolipid metabolism_Homo sapiens_hsa006000.42039048
121Circadian rhythm_Homo sapiens_hsa047100.40279393
122Hedgehog signaling pathway_Homo sapiens_hsa043400.40145116
123Wnt signaling pathway_Homo sapiens_hsa043100.39550321
124Basal cell carcinoma_Homo sapiens_hsa052170.39135225
125Asthma_Homo sapiens_hsa053100.36989234
126Peroxisome_Homo sapiens_hsa041460.35904923
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35218013
128Hippo signaling pathway_Homo sapiens_hsa043900.35122200
129Melanoma_Homo sapiens_hsa052180.35082734
130Oxidative phosphorylation_Homo sapiens_hsa001900.34763676
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33778601
132VEGF signaling pathway_Homo sapiens_hsa043700.33619345
133Endocytosis_Homo sapiens_hsa041440.33072902
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.32815770
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31412630
136TGF-beta signaling pathway_Homo sapiens_hsa043500.30638561
137Vitamin digestion and absorption_Homo sapiens_hsa049770.30154969
138Mineral absorption_Homo sapiens_hsa049780.28853434
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28635701
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28452325
141Parkinsons disease_Homo sapiens_hsa050120.27058580
142Insulin signaling pathway_Homo sapiens_hsa049100.26088073
143mTOR signaling pathway_Homo sapiens_hsa041500.26080340
144Renal cell carcinoma_Homo sapiens_hsa052110.25770695
145Endometrial cancer_Homo sapiens_hsa052130.25204171
146Chemokine signaling pathway_Homo sapiens_hsa040620.24817057

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