SHKBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.89830961
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.89830961
3positive regulation by symbiont of host defense response (GO:0052509)5.39650626
4modulation by symbiont of host defense response (GO:0052031)5.39650626
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.39650626
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.39650626
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.39650626
8modulation by symbiont of host immune response (GO:0052553)5.39650626
9neutrophil activation involved in immune response (GO:0002283)5.19079815
10ribosomal small subunit assembly (GO:0000028)4.94447852
11response to peptidoglycan (GO:0032494)4.80127103
12detection of other organism (GO:0098543)4.70185340
13viral transcription (GO:0019083)4.67077983
14detection of bacterium (GO:0016045)4.65187349
15translational termination (GO:0006415)4.46984947
16DNA deamination (GO:0045006)4.45452401
17macrophage activation involved in immune response (GO:0002281)4.32176310
18negative regulation of interleukin-12 production (GO:0032695)4.13674391
19translational elongation (GO:0006414)4.08409318
20respiratory burst (GO:0045730)3.95994647
21DNA strand elongation involved in DNA replication (GO:0006271)3.92521508
22cellular extravasation (GO:0045123)3.91406506
23neutrophil activation (GO:0042119)3.91101726
24regulation of interferon-beta biosynthetic process (GO:0045357)3.90891698
25sequestering of actin monomers (GO:0042989)3.86102177
26detection of external biotic stimulus (GO:0098581)3.84341758
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.82149995
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.78230323
29positive thymic T cell selection (GO:0045059)3.78166963
30DNA unwinding involved in DNA replication (GO:0006268)3.77704109
31DNA strand elongation (GO:0022616)3.76738042
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76073354
33maturation of SSU-rRNA (GO:0030490)3.74898165
34regulation of mast cell degranulation (GO:0043304)3.74141245
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.73181288
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73181288
37response to host immune response (GO:0052572)3.72284964
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.72284964
39ribosomal small subunit biogenesis (GO:0042274)3.72198931
40telomere maintenance via semi-conservative replication (GO:0032201)3.71705185
41response to interleukin-15 (GO:0070672)3.66473220
42translational initiation (GO:0006413)3.64273603
43protein targeting to ER (GO:0045047)3.64036817
44cotranslational protein targeting to membrane (GO:0006613)3.63141931
45granulocyte activation (GO:0036230)3.62164288
46viral life cycle (GO:0019058)3.57255862
47leukocyte migration involved in inflammatory response (GO:0002523)3.55405770
48cellular protein complex disassembly (GO:0043624)3.54750247
49response to muramyl dipeptide (GO:0032495)3.53771964
50negative regulation of leukocyte mediated immunity (GO:0002704)3.52415192
51response to host (GO:0075136)3.47128666
52response to host defenses (GO:0052200)3.47128666
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.47128666
54protein complex disassembly (GO:0043241)3.47121440
55cellular response to type I interferon (GO:0071357)3.45714791
56type I interferon signaling pathway (GO:0060337)3.45714791
57myeloid cell activation involved in immune response (GO:0002275)3.45377750
58regulation of myeloid leukocyte mediated immunity (GO:0002886)3.45178122
59establishment of protein localization to endoplasmic reticulum (GO:0072599)3.44686827
60response to type I interferon (GO:0034340)3.42501309
61detection of biotic stimulus (GO:0009595)3.42169881
62Arp2/3 complex-mediated actin nucleation (GO:0034314)3.42104037
63protein localization to endoplasmic reticulum (GO:0070972)3.42067388
64positive regulation of gamma-delta T cell activation (GO:0046645)3.42018369
65regulation of mast cell activation involved in immune response (GO:0033006)3.38797755
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.37772051
67detection of molecule of bacterial origin (GO:0032490)3.37723524
68regulation of leukocyte degranulation (GO:0043300)3.37716332
69antigen processing and presentation of endogenous antigen (GO:0019883)3.37345512
70negative regulation of T cell mediated immunity (GO:0002710)3.33905678
71protein retention in ER lumen (GO:0006621)3.32746723
72cellular response to interleukin-15 (GO:0071350)3.32519521
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32515982
74positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32305841
75regulation of dendritic cell antigen processing and presentation (GO:0002604)3.32010649
76formation of translation preinitiation complex (GO:0001731)3.31416234
77DNA replication initiation (GO:0006270)3.30600996
78negative thymic T cell selection (GO:0045060)3.26065643
79ribosomal large subunit biogenesis (GO:0042273)3.25641735
80negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.24054674
81negative regulation of RNA splicing (GO:0033119)3.23783050
82regulation of T cell tolerance induction (GO:0002664)3.22265853
83macromolecular complex disassembly (GO:0032984)3.21569785
84regulation of gamma-delta T cell differentiation (GO:0045586)3.20225381
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.18140466
86dosage compensation (GO:0007549)3.18002384
87germinal center formation (GO:0002467)3.17988131
88defense response to protozoan (GO:0042832)3.15538173
89lipopolysaccharide-mediated signaling pathway (GO:0031663)3.14692795
90negative T cell selection (GO:0043383)3.14687792
91telomere maintenance via recombination (GO:0000722)3.13850624
92leukocyte degranulation (GO:0043299)3.13283844
93tolerance induction (GO:0002507)3.09176074
94interferon-gamma-mediated signaling pathway (GO:0060333)3.06777525
95negative regulation of innate immune response (GO:0045824)3.06334178
96nucleosome disassembly (GO:0006337)3.06206046
97protein-DNA complex disassembly (GO:0032986)3.06206046
98positive regulation of mast cell activation (GO:0033005)3.05441109
99macrophage activation (GO:0042116)3.03429720
100regulation of mast cell activation (GO:0033003)3.02588847
101regulation of tolerance induction (GO:0002643)3.02555942
102production of molecular mediator involved in inflammatory response (GO:0002532)3.02545580
103neutrophil mediated immunity (GO:0002446)3.01818800
104regulation of antigen processing and presentation (GO:0002577)2.99575937
105regulation of T cell mediated cytotoxicity (GO:0001914)2.99389852
106microglial cell activation (GO:0001774)2.98521650
107regulation of T-helper 2 cell differentiation (GO:0045628)2.97713028
108positive regulation of T cell mediated cytotoxicity (GO:0001916)2.97417071
109maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.97185129
110nuclear-transcribed mRNA catabolic process (GO:0000956)2.96298446
111regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.95774136
112regulation of natural killer cell mediated immunity (GO:0002715)2.95774136
113positive regulation of antigen processing and presentation (GO:0002579)2.92455065
114negative regulation of cytokine production involved in immune response (GO:0002719)2.92241091
115mitotic recombination (GO:0006312)2.90678020
116response to protozoan (GO:0001562)2.90621307
117negative regulation of interleukin-6 production (GO:0032715)2.88904134
118regulation of gamma-delta T cell activation (GO:0046643)2.87437163
119positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.87245348
120T cell selection (GO:0045058)2.85055937
121T cell migration (GO:0072678)2.83714146
122regulation of regulated secretory pathway (GO:1903305)2.81641251
123mRNA catabolic process (GO:0006402)2.80737565
124positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80619281
125negative regulation of phagocytosis (GO:0050765)2.77361613
1263-UTR-mediated mRNA stabilization (GO:0070935)2.75909001
127RNA catabolic process (GO:0006401)2.75222100
128heterochromatin organization (GO:0070828)2.74985867
129regulation of protein heterodimerization activity (GO:0043497)2.74895371
130barbed-end actin filament capping (GO:0051016)2.73135702
131pentose-phosphate shunt (GO:0006098)2.72168560
132telomere maintenance via telomere lengthening (GO:0010833)2.71388937
133antigen processing and presentation via MHC class Ib (GO:0002475)2.70436347
134IMP biosynthetic process (GO:0006188)2.69239527
135folic acid-containing compound biosynthetic process (GO:0009396)2.67874046
136positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66517260
137positive regulation of B cell differentiation (GO:0045579)2.65592780
138positive T cell selection (GO:0043368)2.64625705
139translation (GO:0006412)2.60743890
140base-excision repair (GO:0006284)2.59133900
141leukocyte aggregation (GO:0070486)2.59003737
142negative regulation of glycoprotein biosynthetic process (GO:0010561)2.58422019
143ribonucleoprotein complex biogenesis (GO:0022613)2.58093220
144nodal signaling pathway (GO:0038092)2.57598323
145nucleotide-excision repair, DNA gap filling (GO:0006297)2.57411739
146negative regulation of mRNA processing (GO:0050686)2.56887265
147translesion synthesis (GO:0019985)2.55924642
148protein localization to kinetochore (GO:0034501)2.55439054
149regulation of B cell differentiation (GO:0045577)2.52812499
150protein localization to chromosome, centromeric region (GO:0071459)2.52792686
151thymic T cell selection (GO:0045061)2.51155133
152negative regulation of erythrocyte differentiation (GO:0045647)2.49176960
153mitotic nuclear envelope disassembly (GO:0007077)2.49099943
154regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48931202
155termination of RNA polymerase II transcription (GO:0006369)2.48578203
156regulation of B cell receptor signaling pathway (GO:0050855)2.47398058
157B cell mediated immunity (GO:0019724)2.46866452
158NIK/NF-kappaB signaling (GO:0038061)2.46552636
159regulation of histone H3-K9 methylation (GO:0051570)2.44611217
160regulation of erythrocyte differentiation (GO:0045646)2.43799675
161transcription-coupled nucleotide-excision repair (GO:0006283)2.42599622
162B cell receptor signaling pathway (GO:0050853)2.42284447
163DNA duplex unwinding (GO:0032508)2.41627291
164negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.39636352
165nucleobase biosynthetic process (GO:0046112)2.39573720
166immunoglobulin mediated immune response (GO:0016064)2.39091801
167DNA geometric change (GO:0032392)2.38960227
168regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.38293712
169RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.37419185
170mRNA splicing, via spliceosome (GO:0000398)2.37419185
171determination of adult lifespan (GO:0008340)2.37165884
172rRNA processing (GO:0006364)2.35984435
173regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.35837765
174DNA replication-dependent nucleosome organization (GO:0034723)2.35639639
175DNA replication-dependent nucleosome assembly (GO:0006335)2.35639639
176RNA splicing, via transesterification reactions (GO:0000375)2.33211982
177DNA replication checkpoint (GO:0000076)2.33173145
178viral mRNA export from host cell nucleus (GO:0046784)2.33093348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.48039991
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.63056927
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58788545
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.03688718
5MYC_22102868_ChIP-Seq_BL_Human3.00845404
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.93408391
7VDR_21846776_ChIP-Seq_THP-1_Human2.58456511
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.46148268
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42711727
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.30706973
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23040248
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21942180
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15279438
14SPI1_23127762_ChIP-Seq_K562_Human2.10652056
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10368567
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06297804
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05416892
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.03939404
19XRN2_22483619_ChIP-Seq_HELA_Human1.99573527
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94145830
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.92913085
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86485951
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85814336
24CIITA_25753668_ChIP-Seq_RAJI_Human1.85527923
25RUNX_20019798_ChIP-Seq_JUKART_Human1.83760764
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83421696
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79203153
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78292432
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70334398
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69949484
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.69520864
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68924999
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68212820
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66227242
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65558107
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.64778211
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64162667
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61843478
39VDR_23849224_ChIP-Seq_CD4+_Human1.59993250
40UTX_26944678_Chip-Seq_JUKART_Human1.59617202
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59304618
42VDR_24763502_ChIP-Seq_THP-1_Human1.58826692
43MAF_26560356_Chip-Seq_TH1_Human1.58557435
44* SPI1_23547873_ChIP-Seq_NB4_Human1.55143503
45SCL_19346495_ChIP-Seq_HPC-7_Human1.54669429
46FOXP3_21729870_ChIP-Seq_TREG_Human1.54555991
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.54334971
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53536307
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53250723
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52400040
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51938788
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51634355
53GABP_19822575_ChIP-Seq_HepG2_Human1.46164634
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45451215
55* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44601115
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42708806
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42705397
58* TCF7_22412390_ChIP-Seq_EML_Mouse1.42332008
59* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42153258
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41858257
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41298081
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40912983
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.40619581
64* RUNX1_22412390_ChIP-Seq_EML_Mouse1.39703348
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38716710
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.38621133
67MAF_26560356_Chip-Seq_TH2_Human1.37532399
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36900921
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34804613
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34699584
71* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34576194
72DCP1A_22483619_ChIP-Seq_HELA_Human1.32680053
73* BCOR_27268052_Chip-Seq_Bcells_Human1.32588607
74MYB_26560356_Chip-Seq_TH2_Human1.32477979
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32437011
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.32226236
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31533002
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30941855
79MYB_26560356_Chip-Seq_TH1_Human1.30031504
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.29972891
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28942294
82RACK7_27058665_Chip-Seq_MCF-7_Human1.28781011
83GATA3_27048872_Chip-Seq_THYMUS_Human1.27650271
84TTF2_22483619_ChIP-Seq_HELA_Human1.27442032
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.26397780
86* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26198810
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26070223
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25653651
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25215538
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25107632
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24666293
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23121612
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21701695
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21517781
95NCOR1_26117541_ChIP-Seq_K562_Human1.20927490
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20404590
97KDM2B_26808549_Chip-Seq_DND41_Human1.20198102
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.19000581
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18630634
100* P68_20966046_ChIP-Seq_HELA_Human1.18461847
101* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17883963
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17118306
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.17063135
104MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16454343
105* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15969118
106* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15469100
107CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13722381
108MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12990646
109KDM5A_27292631_Chip-Seq_BREAST_Human1.12655977
110MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11863745
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10860902
112THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10757064
113* LXR_22292898_ChIP-Seq_THP-1_Human1.10359003
114SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09654752
115RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08776953
116* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08701043
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07902373
118* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07297084
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07196790
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06755679
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06307389
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05235102
123NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05015164
124TP63_19390658_ChIP-ChIP_HaCaT_Human1.04387546
125KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02819064
126KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01328181
127TFEB_21752829_ChIP-Seq_HELA_Human1.00838313
128* TET1_21451524_ChIP-Seq_MESCs_Mouse1.00051047
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99982611
130YY1_21170310_ChIP-Seq_MESCs_Mouse0.99923732
131PU_27001747_Chip-Seq_BMDM_Mouse0.99923612
132VDR_24787735_ChIP-Seq_THP-1_Human0.99749982
133RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99496669
134PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99416744
135GATA1_19941826_ChIP-Seq_K562_Human0.98967033
136CTCF_26484167_Chip-Seq_Bcells_Mouse0.98592064
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96942396
138FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95694342
139PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94623695
140* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93501468
141SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93450948
142POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92978542
143DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92286034
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92150865
145* BCL6_27268052_Chip-Seq_Bcells_Human0.91819019
146SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90225378
147* SPI1_20517297_ChIP-Seq_HL60_Human0.89840667
148STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89718734
149IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89080667
150CTCF_21964334_ChIP-Seq_BJAB-B_Human0.87100498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.24002967
2MP0003303_peritoneal_inflammation3.43691516
3MP0009278_abnormal_bone_marrow2.92930056
4MP0002396_abnormal_hematopoietic_system2.90750464
5MP0004957_abnormal_blastocyst_morpholog2.84916805
6MP0003111_abnormal_nucleus_morphology2.74327393
7MP0003077_abnormal_cell_cycle2.70286318
8MP0001835_abnormal_antigen_presentation2.62164427
9MP0005397_hematopoietic_system_phenotyp2.59378492
10MP0001545_abnormal_hematopoietic_system2.59378492
11MP0010352_gastrointestinal_tract_polyps2.41141711
12MP0003763_abnormal_thymus_physiology2.33805422
13MP0000685_abnormal_immune_system2.33217469
14MP0003191_abnormal_cellular_cholesterol2.27739279
15MP0010094_abnormal_chromosome_stability2.26815478
16MP0002398_abnormal_bone_marrow2.19101898
17MP0005671_abnormal_response_to2.17915146
18MP0003436_decreased_susceptibility_to2.17286722
19MP0009333_abnormal_splenocyte_physiolog2.15120769
20MP0001800_abnormal_humoral_immune2.10108255
21MP0004808_abnormal_hematopoietic_stem2.02743246
22MP0003172_abnormal_lysosome_physiology1.97674656
23MP0002420_abnormal_adaptive_immunity1.89931186
24MP0002452_abnormal_antigen_presenting1.88190541
25MP0001819_abnormal_immune_cell1.88180941
26MP0005076_abnormal_cell_differentiation1.87565217
27MP0002722_abnormal_immune_system1.87072209
28MP0000689_abnormal_spleen_morphology1.87060452
29MP0000465_gastrointestinal_hemorrhage1.85236484
30MP0000490_abnormal_crypts_of1.83457220
31MP0005058_abnormal_lysosome_morphology1.82106134
32MP0000716_abnormal_immune_system1.81221086
33MP0005000_abnormal_immune_tolerance1.80313538
34MP0008007_abnormal_cellular_replicative1.79784839
35MP0002723_abnormal_immune_serum1.78806577
36MP0005025_abnormal_response_to1.76621088
37MP0008058_abnormal_DNA_repair1.75652753
38MP0000703_abnormal_thymus_morphology1.72723740
39MP0000858_altered_metastatic_potential1.72564332
40MP0005451_abnormal_body_composition1.72078413
41MP0009785_altered_susceptibility_to1.70151569
42MP0002429_abnormal_blood_cell1.68339942
43MP0008057_abnormal_DNA_replication1.67662617
44MP0005387_immune_system_phenotype1.61184908
45MP0001790_abnormal_immune_system1.61184908
46MP0002405_respiratory_system_inflammati1.61028800
47MP0005464_abnormal_platelet_physiology1.51948196
48MP0003828_pulmonary_edema1.48807906
49MP0001730_embryonic_growth_arrest1.48506231
50MP0002019_abnormal_tumor_incidence1.44088588
51MP0010155_abnormal_intestine_physiology1.41778899
52MP0000313_abnormal_cell_death1.40624811
53MP0009764_decreased_sensitivity_to1.39895403
54MP0000350_abnormal_cell_proliferation1.38897195
55MP0004510_myositis1.37761399
56MP0005310_abnormal_salivary_gland1.37745077
57MP0002419_abnormal_innate_immunity1.37605282
58MP0002166_altered_tumor_susceptibility1.31928001
59MP0003183_abnormal_peptide_metabolism1.30655406
60MP0003866_abnormal_defecation1.29210908
61MP0001853_heart_inflammation1.28016859
62MP0008932_abnormal_embryonic_tissue1.27691453
63MP0010307_abnormal_tumor_latency1.27649634
64MP0001873_stomach_inflammation1.27068345
65MP0003300_gastrointestinal_ulcer1.26056482
66MP0003075_altered_response_to1.25744022
67MP0001851_eye_inflammation1.22923356
68MP0002998_abnormal_bone_remodeling1.18449464
69MP0002148_abnormal_hypersensitivity_rea1.16888631
70MP0004381_abnormal_hair_follicle1.16011939
71MP0001845_abnormal_inflammatory_respons1.15094996
72MP0006054_spinal_hemorrhage1.14407760
73MP0003724_increased_susceptibility_to1.10513444
74MP0004947_skin_inflammation1.08536613
75MP0002277_abnormal_respiratory_mucosa1.08087456
76MP0006082_CNS_inflammation1.07553001
77MP0003705_abnormal_hypodermis_morpholog1.06874592
78MP0005023_abnormal_wound_healing1.05216978
79MP0005174_abnormal_tail_pigmentation1.05043071
80MP0002080_prenatal_lethality1.01752280
81MP0000358_abnormal_cell_content/1.01740155
82MP0004883_abnormal_blood_vessel1.00184805
83MP0000343_altered_response_to0.99901807
84MP0002006_tumorigenesis0.99270479
85MP0005075_abnormal_melanosome_morpholog0.99249930
86MP0001697_abnormal_embryo_size0.99047040
87MP0005390_skeleton_phenotype0.98125339
88MP0002086_abnormal_extraembryonic_tissu0.96178671
89MP0005166_decreased_susceptibility_to0.95207990
90MP0000477_abnormal_intestine_morphology0.94948767
91MP0001672_abnormal_embryogenesis/_devel0.94541607
92MP0005380_embryogenesis_phenotype0.94541607
93MP0003786_premature_aging0.93298558
94MP0003984_embryonic_growth_retardation0.92144262
95MP0002132_abnormal_respiratory_system0.91893726
96MP0003011_delayed_dark_adaptation0.91689756
97MP0003566_abnormal_cell_adhesion0.91158350
98MP0002088_abnormal_embryonic_growth/wei0.88983973
99MP0002933_joint_inflammation0.85301374
100MP0008004_abnormal_stomach_pH0.84529785
101MP0009763_increased_sensitivity_to0.84460310
102MP0009840_abnormal_foam_cell0.84146041
103MP0008789_abnormal_olfactory_epithelium0.84119560
104MP0001849_ear_inflammation0.83781979
105MP0003448_altered_tumor_morphology0.83238668
106MP0005621_abnormal_cell_physiology0.80442768
107MP0008260_abnormal_autophagy0.79952353
108MP0005164_abnormal_response_to0.79661020
109MP0002085_abnormal_embryonic_tissue0.78888606
110MP0009053_abnormal_anal_canal0.77802500
111MP0005384_cellular_phenotype0.76458385
112MP0001533_abnormal_skeleton_physiology0.75603447
113MP0008469_abnormal_protein_level0.74529575
114MP0002138_abnormal_hepatobiliary_system0.74150073
115MP0000604_amyloidosis0.72837055
116MP0003795_abnormal_bone_structure0.72511633
117MP0002084_abnormal_developmental_patter0.71810724
118MP0000015_abnormal_ear_pigmentation0.71298217
119MP0008961_abnormal_basal_metabolism0.70432398
120MP0001663_abnormal_digestive_system0.70135274
121MP0001293_anophthalmia0.67243783
122MP0004858_abnormal_nervous_system0.65941853
123MP0004197_abnormal_fetal_growth/weight/0.65879451
124MP0000598_abnormal_liver_morphology0.65338042
125MP0000249_abnormal_blood_vessel0.64644032
126MP0002254_reproductive_system_inflammat0.63635083
127MP0003806_abnormal_nucleotide_metabolis0.62145899
128MP0003453_abnormal_keratinocyte_physiol0.61630831
129MP0008874_decreased_physiological_sensi0.61352245
130MP0003656_abnormal_erythrocyte_physiolo0.60612173
131MP0009765_abnormal_xenobiotic_induced0.60231360
132MP0003091_abnormal_cell_migration0.58330885
133MP0005319_abnormal_enzyme/_coenzyme0.57070013
134MP0003690_abnormal_glial_cell0.56509142
135MP0003045_fibrosis0.53558423
136MP0005381_digestive/alimentary_phenotyp0.52386913
137MP0005083_abnormal_biliary_tract0.49597063
138MP0000609_abnormal_liver_physiology0.48352383

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)4.68819123
2Stomatitis (HP:0010280)4.66740536
3Recurrent gram-negative bacterial infections (HP:0005420)4.38507357
4Optic neuritis (HP:0100653)4.19838268
5Retrobulbar optic neuritis (HP:0100654)4.19838268
6Large eyes (HP:0001090)4.09124537
7Microretrognathia (HP:0000308)3.80941567
8Broad distal phalanx of finger (HP:0009836)3.73744918
9Nasal polyposis (HP:0100582)3.64088389
10IgM deficiency (HP:0002850)3.56711915
11Chronic otitis media (HP:0000389)3.55882405
12Reticulocytopenia (HP:0001896)3.45693482
13Thrombocytosis (HP:0001894)3.42447271
14Encephalitis (HP:0002383)3.41239200
15Urticaria (HP:0001025)3.39558257
16Aplasia/Hypoplasia of the sacrum (HP:0008517)3.37678911
17Abnormality of the nasal mucosa (HP:0000433)3.31077331
18Abnormal number of erythroid precursors (HP:0012131)3.30738044
19Abnormality of cells of the erythroid lineage (HP:0012130)3.30724239
20Abnormality of the fingertips (HP:0001211)3.29405524
21Gingivitis (HP:0000230)3.25321630
22Hypochromic anemia (HP:0001931)3.24861832
23Recurrent abscess formation (HP:0002722)3.21764687
24Elevated erythrocyte sedimentation rate (HP:0003565)3.16399378
25Eczematoid dermatitis (HP:0000976)3.13808921
26Rectal prolapse (HP:0002035)3.12380698
27Medulloblastoma (HP:0002885)3.08748291
28Chest pain (HP:0100749)3.03853058
29Keratoconjunctivitis sicca (HP:0001097)2.99719058
30Cellulitis (HP:0100658)2.91493313
31Aplastic anemia (HP:0001915)2.90151545
32Increased IgM level (HP:0003496)2.90132614
33Patent foramen ovale (HP:0001655)2.89317742
34Recurrent bronchitis (HP:0002837)2.84030840
35Colon cancer (HP:0003003)2.83654489
36Petechiae (HP:0000967)2.79086936
37Episodic fever (HP:0001954)2.78712616
38Pulmonary infiltrates (HP:0002113)2.78442681
39Keratoconjunctivitis (HP:0001096)2.74041226
40Increased cerebral lipofuscin (HP:0011813)2.73087092
41Recurrent bacterial skin infections (HP:0005406)2.72618163
42Bicuspid aortic valve (HP:0001647)2.70489499
43Poikiloderma (HP:0001029)2.66381333
44Purpura (HP:0000979)2.62620500
45Hemoptysis (HP:0002105)2.62512403
46Hypochromic microcytic anemia (HP:0004840)2.61244858
47Abnormality of macrophages (HP:0004311)2.60783571
48Pallor (HP:0000980)2.58249572
49Amyloidosis (HP:0011034)2.57897464
50Cortical dysplasia (HP:0002539)2.57717665
51Gastrointestinal infarctions (HP:0005244)2.56423027
52Gingival bleeding (HP:0000225)2.55512809
53Agnosia (HP:0010524)2.55508580
54Granulocytopenia (HP:0001913)2.55025398
55Abnormality of liposaccharide metabolism (HP:0010968)2.54989335
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.54989335
57Abnormality of glycolipid metabolism (HP:0010969)2.54989335
58Recurrent fungal infections (HP:0002841)2.54233553
59Osteomyelitis (HP:0002754)2.52846450
60Hepatosplenomegaly (HP:0001433)2.52274547
61Recurrent viral infections (HP:0004429)2.51079174
62Hypergammaglobulinemia (HP:0010702)2.51011071
63Increased serum ferritin (HP:0003281)2.48245917
64Obstructive lung disease (HP:0006536)2.45266958
65Chronic obstructive pulmonary disease (HP:0006510)2.45266958
66Anorexia (HP:0002039)2.45072734
67Sepsis (HP:0100806)2.42501503
68Arterial thrombosis (HP:0004420)2.41627957
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.41218597
70Loss of speech (HP:0002371)2.40055917
71Abnormality of T cells (HP:0002843)2.35800025
72Abnormality of DNA repair (HP:0003254)2.35314657
73Lymphoma (HP:0002665)2.31085085
74Meningitis (HP:0001287)2.29634074
75Abnormality of cells of the lymphoid lineage (HP:0012140)2.29195656
76Prolonged bleeding time (HP:0003010)2.28280333
77Agammaglobulinemia (HP:0004432)2.27761347
78Basal cell carcinoma (HP:0002671)2.27692570
79Lymphopenia (HP:0001888)2.26690404
80Pustule (HP:0200039)2.26618269
81Peritonitis (HP:0002586)2.25914050
82Hypertensive crisis (HP:0100735)2.25377538
83Abnormality of T cell physiology (HP:0011840)2.23503166
84Panhypogammaglobulinemia (HP:0003139)2.23021539
85Pulmonary embolism (HP:0002204)2.21529411
86Patellar aplasia (HP:0006443)2.20488603
87Selective tooth agenesis (HP:0001592)2.19215126
88Abnormality of iron homeostasis (HP:0011031)2.17301864
89Gastrointestinal inflammation (HP:0004386)2.15910251
90Mediastinal lymphadenopathy (HP:0100721)2.15600914
91Multiple enchondromatosis (HP:0005701)2.14569714
92Skin ulcer (HP:0200042)2.14450199
93Dysostosis multiplex (HP:0000943)2.14120681
94Myositis (HP:0100614)2.12782793
95Abnormality of the pleura (HP:0002103)2.12486232
96Premature loss of primary teeth (HP:0006323)2.11327525
97Myelodysplasia (HP:0002863)2.10075286
98Abnormal platelet volume (HP:0011876)2.10015655
99Impaired platelet aggregation (HP:0003540)2.08741777
100Abnormal platelet function (HP:0011869)2.08741777
101Macrocytic anemia (HP:0001972)2.08296652
10211 pairs of ribs (HP:0000878)2.08012223
103Glomerulopathy (HP:0100820)2.07213900
104Abnormality of the peritoneum (HP:0002585)2.05477079
105T lymphocytopenia (HP:0005403)2.05286312
106Combined immunodeficiency (HP:0005387)2.04713849
107Absent thumb (HP:0009777)2.03668976
108B lymphocytopenia (HP:0010976)2.02010672
109Abnormality of B cell number (HP:0010975)2.02010672
110Aplasia/Hypoplasia of the patella (HP:0006498)2.01773500
111Esophageal neoplasm (HP:0100751)2.01360841
112Neoplasm of head and neck (HP:0012288)2.01360841
113Verrucae (HP:0200043)2.01269426
114Papilloma (HP:0012740)2.01269426
115Neoplasm of the pancreas (HP:0002894)2.01047568
116Birth length less than 3rd percentile (HP:0003561)2.00832713
117Microcytic anemia (HP:0001935)2.00024250
118Inflammation of the large intestine (HP:0002037)1.97152115
119Recurrent lower respiratory tract infections (HP:0002783)1.97127507
120Gangrene (HP:0100758)1.96457632
121Amaurosis fugax (HP:0100576)1.94741933
122Viral hepatitis (HP:0006562)1.92946993
123Recurrent pneumonia (HP:0006532)1.92643444
124Biliary tract neoplasm (HP:0100574)1.91771023
125Skin rash (HP:0000988)1.91408409
126Abnormality of reticulocytes (HP:0004312)1.91346198
127Abnormality of T cell number (HP:0011839)1.91005945
128Entropion (HP:0000621)1.90602242
129Severe combined immunodeficiency (HP:0004430)1.90527650
130Recurrent skin infections (HP:0001581)1.90096582
131Restrictive lung disease (HP:0002091)1.90077153
132Acne (HP:0001061)1.88828821
133Slow saccadic eye movements (HP:0000514)1.88659142
134Oral leukoplakia (HP:0002745)1.88576369
135Autoimmune thrombocytopenia (HP:0001973)1.88314240
136Autoimmune hemolytic anemia (HP:0001890)1.87720307
137Acute hepatic failure (HP:0006554)1.87295372
138Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86686599
139Broad face (HP:0000283)1.84750634
140Hyperacusis (HP:0010780)1.84426313
141IgG deficiency (HP:0004315)1.83270020
142Spontaneous hematomas (HP:0007420)1.83019613
143Epistaxis (HP:0000421)1.81721012
144Abnormal delayed hypersensitivity skin test (HP:0002963)1.81533656
145Interstitial pulmonary disease (HP:0006530)1.80230184
146Gastrointestinal stroma tumor (HP:0100723)1.79962359
147Vasculitis (HP:0002633)1.78608162
148Rough bone trabeculation (HP:0100670)1.78556456
149Leukocytosis (HP:0001974)1.78065249
150Increased IgE level (HP:0003212)1.77667408
151Increased density of long bones (HP:0006392)1.77316217
152Vacuolated lymphocytes (HP:0001922)1.76930750
153High pitched voice (HP:0001620)1.75043634
154Ependymoma (HP:0002888)1.73522684
155Recurrent cutaneous fungal infections (HP:0011370)1.73300159
156Chronic mucocutaneous candidiasis (HP:0002728)1.73300159
157Colitis (HP:0002583)1.72302744

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.98873182
2EEF2K3.87322429
3MAP4K13.76483141
4MAP3K103.38806686
5BUB12.93812736
6TESK22.71492174
7RPS6KA42.56765809
8PRPF4B2.47415318
9NEK22.44009238
10ACVR1B2.36099335
11TNK22.25440472
12KDR2.07558525
13ERN12.05614309
14SMG11.86309180
15BRD41.82084728
16TAOK11.81667991
17EPHB11.81164922
18BLK1.72991743
19STK101.70223455
20RPS6KB21.68083975
21ZAP701.67116295
22WEE11.66913329
23MAP3K141.65138191
24NME21.62431886
25PKN21.56820858
26BTK1.54545899
27IRAK31.54493288
28KIT1.46184948
29GRK61.45833596
30TAOK31.44493538
31FLT31.41640248
32MAPKAPK31.40072618
33DYRK31.38425498
34STK161.38102538
35FGR1.37160684
36TAOK21.36472605
37TYK21.34657535
38IRAK41.33534240
39LRRK21.33159433
40CDK121.32040690
41CSF1R1.28714645
42CDC71.27892738
43TRIB31.27647401
44PAK41.26956068
45MAP3K111.26361768
46TBK11.25624935
47SCYL21.24394155
48MAP3K11.24147011
49MAP3K131.22191705
50SIK11.21111247
51PRKD21.17703908
52MAP2K31.12290889
53PIM21.09765667
54NEK11.06603048
55CDK41.06097219
56TESK11.02517287
57PIM11.02337276
58JAK11.01909008
59JAK31.00953549
60JAK20.99754755
61TXK0.96928045
62MAP3K80.94990511
63KSR20.92587321
64SYK0.91882323
65EIF2AK10.91507396
66MARK20.91400905
67CLK10.91051188
68IRAK20.90366440
69HCK0.86711139
70CDK70.86450568
71ITK0.86134857
72AURKB0.86074259
73TEC0.85975720
74IKBKE0.84880678
75RPS6KA50.81422863
76TGFBR10.79882243
77ATR0.78717099
78PDK10.78119469
79EIF2AK30.77537226
80SIK20.77320330
81TGFBR20.75779688
82ERBB30.75404601
83PDPK10.74371996
84CSK0.73339906
85LCK0.72952678
86CDC42BPA0.72895651
87MKNK10.72746107
88IRAK10.72246105
89TLK10.71033572
90LYN0.70217940
91RPS6KA60.68978247
92MAP3K20.67679341
93RPS6KA20.67013266
94TSSK60.66872032
95RPS6KL10.65557433
96RPS6KC10.65557433
97HIPK20.65092731
98PASK0.63332002
99MAP2K20.62012727
100PAK10.61313575
101PLK10.61151752
102TRPM70.60555419
103NLK0.60229092
104YES10.58389990
105CDK190.58000072
106MARK30.57442591
107FES0.56855795
108MAP3K60.56404637
109DYRK1B0.55959147
110PTK60.54800346
111STK40.54471421
112ALK0.54449749
113TTN0.53422306
114MAPK120.53390353
115BMPR20.52526203
116MAP3K70.51119892
117FYN0.51111109
118IKBKB0.50907987
119RPS6KA10.48999635
120MATK0.48830069
121PRKG20.48395051
122MAPK110.47959982
123TTK0.47825011
124CDK60.47493349
125ICK0.47089728
126CHUK0.46230978
127SRPK10.46127473
128SIK30.45351594
129MAPK70.45075027
130PLK40.44829859
131PTK2B0.42943662
132MAPKAPK20.42832331
133FGFR40.42210896
134BMX0.41888632
135PRKCQ0.41610480
136EPHA20.41141904
137MAP3K30.39789418
138MAP3K50.39736217
139MTOR0.37843051
140ARAF0.35127375
141BCKDK0.34952178
142MOS0.32469180
143GRK70.31401924
144STK380.31389625
145MAP2K60.30597671
146RAF10.28139439

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.15910027
2Ribosome_Homo sapiens_hsa030103.72048676
3Mismatch repair_Homo sapiens_hsa034303.23938450
4Spliceosome_Homo sapiens_hsa030402.85192906
5Base excision repair_Homo sapiens_hsa034102.61091130
6Primary immunodeficiency_Homo sapiens_hsa053402.52975582
7Graft-versus-host disease_Homo sapiens_hsa053322.51942890
8Staphylococcus aureus infection_Homo sapiens_hsa051502.47839096
9Autoimmune thyroid disease_Homo sapiens_hsa053202.36865583
10Nucleotide excision repair_Homo sapiens_hsa034202.26961839
11Proteasome_Homo sapiens_hsa030502.20902938
12Homologous recombination_Homo sapiens_hsa034401.82834770
13Antigen processing and presentation_Homo sapiens_hsa046121.77914198
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77683619
15Type I diabetes mellitus_Homo sapiens_hsa049401.76301775
16RNA transport_Homo sapiens_hsa030131.74879795
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65881768
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61891485
19B cell receptor signaling pathway_Homo sapiens_hsa046621.60523249
20Cell cycle_Homo sapiens_hsa041101.59550880
21RNA polymerase_Homo sapiens_hsa030201.57499921
22Leishmaniasis_Homo sapiens_hsa051401.54773129
23Pyrimidine metabolism_Homo sapiens_hsa002401.53951502
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50898698
25Herpes simplex infection_Homo sapiens_hsa051681.48140170
26One carbon pool by folate_Homo sapiens_hsa006701.47531751
27Sulfur relay system_Homo sapiens_hsa041221.44440164
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.37156894
29Measles_Homo sapiens_hsa051621.35594455
30Phagosome_Homo sapiens_hsa041451.33988430
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29775503
32Shigellosis_Homo sapiens_hsa051311.29558318
33Systemic lupus erythematosus_Homo sapiens_hsa053221.29074431
34Hematopoietic cell lineage_Homo sapiens_hsa046401.28262844
35p53 signaling pathway_Homo sapiens_hsa041151.28221860
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27764460
37Epstein-Barr virus infection_Homo sapiens_hsa051691.24140793
38Acute myeloid leukemia_Homo sapiens_hsa052211.24043819
39Fanconi anemia pathway_Homo sapiens_hsa034601.17464190
40Apoptosis_Homo sapiens_hsa042101.17176483
41African trypanosomiasis_Homo sapiens_hsa051431.15210532
42Chronic myeloid leukemia_Homo sapiens_hsa052201.12767094
43Rheumatoid arthritis_Homo sapiens_hsa053231.11987666
44Non-homologous end-joining_Homo sapiens_hsa034501.11562227
45RNA degradation_Homo sapiens_hsa030181.09616004
46Lysosome_Homo sapiens_hsa041421.09591875
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.09539235
48Osteoclast differentiation_Homo sapiens_hsa043801.08826142
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07895793
50Other glycan degradation_Homo sapiens_hsa005111.06877617
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06513011
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.05386535
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05344540
54T cell receptor signaling pathway_Homo sapiens_hsa046601.03836216
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.03765471
56Pentose phosphate pathway_Homo sapiens_hsa000301.01317251
57Colorectal cancer_Homo sapiens_hsa052101.01146579
58Viral carcinogenesis_Homo sapiens_hsa052031.00070785
59mRNA surveillance pathway_Homo sapiens_hsa030150.99728923
60Legionellosis_Homo sapiens_hsa051340.98370036
61Hepatitis B_Homo sapiens_hsa051610.97436332
62HTLV-I infection_Homo sapiens_hsa051660.95654239
63Small cell lung cancer_Homo sapiens_hsa052220.95405698
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94184661
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93523319
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91671994
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88957264
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.87755349
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86837905
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86622225
71Notch signaling pathway_Homo sapiens_hsa043300.85872661
72Endocytosis_Homo sapiens_hsa041440.85478774
73Toxoplasmosis_Homo sapiens_hsa051450.84208400
74Thyroid cancer_Homo sapiens_hsa052160.80411668
75Folate biosynthesis_Homo sapiens_hsa007900.80379428
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80004486
77Influenza A_Homo sapiens_hsa051640.79259079
78Viral myocarditis_Homo sapiens_hsa054160.72551477
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.71344938
80Asthma_Homo sapiens_hsa053100.70660472
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69139255
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68962090
83Pancreatic cancer_Homo sapiens_hsa052120.66240222
84Prolactin signaling pathway_Homo sapiens_hsa049170.66152513
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65527745
86Renal cell carcinoma_Homo sapiens_hsa052110.64450435
87Pertussis_Homo sapiens_hsa051330.64341032
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64311970
89MicroRNAs in cancer_Homo sapiens_hsa052060.61213116
90Non-small cell lung cancer_Homo sapiens_hsa052230.61005604
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60612937
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60537600
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.60205078
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57435257
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.56932006
96Amoebiasis_Homo sapiens_hsa051460.56095314
97VEGF signaling pathway_Homo sapiens_hsa043700.55771251
98Tuberculosis_Homo sapiens_hsa051520.54737919
99Endometrial cancer_Homo sapiens_hsa052130.54395380
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.53918882
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.53759179
102Salmonella infection_Homo sapiens_hsa051320.53733960
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.53233193
104mTOR signaling pathway_Homo sapiens_hsa041500.52266689
105Basal transcription factors_Homo sapiens_hsa030220.51659029
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50916712
107Platelet activation_Homo sapiens_hsa046110.49991555
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48093125
109TNF signaling pathway_Homo sapiens_hsa046680.46468044
110Chemokine signaling pathway_Homo sapiens_hsa040620.46302069
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45548726
112Hepatitis C_Homo sapiens_hsa051600.45405949
113Purine metabolism_Homo sapiens_hsa002300.45130308
114Choline metabolism in cancer_Homo sapiens_hsa052310.43716036
115N-Glycan biosynthesis_Homo sapiens_hsa005100.43642281
116Malaria_Homo sapiens_hsa051440.42895082
117HIF-1 signaling pathway_Homo sapiens_hsa040660.41942289
118Allograft rejection_Homo sapiens_hsa053300.41450629
119Galactose metabolism_Homo sapiens_hsa000520.41248202
120Bladder cancer_Homo sapiens_hsa052190.40607903
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40602852
122FoxO signaling pathway_Homo sapiens_hsa040680.40233917
123Insulin resistance_Homo sapiens_hsa049310.39810679
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39494950
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39090274
126Pathways in cancer_Homo sapiens_hsa052000.38714094
127Biosynthesis of amino acids_Homo sapiens_hsa012300.38122898
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36733306
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.36578238
130Alcoholism_Homo sapiens_hsa050340.36389752
131GnRH signaling pathway_Homo sapiens_hsa049120.36280617
132Inositol phosphate metabolism_Homo sapiens_hsa005620.36218316
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35662241
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.32173297
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31337347
136MAPK signaling pathway_Homo sapiens_hsa040100.31234933
137Regulation of autophagy_Homo sapiens_hsa041400.29176433
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29074610
139Insulin signaling pathway_Homo sapiens_hsa049100.27725842

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