SHMT1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dicarboxylic acid catabolic process (GO:0043649)7.92059376
2neurotransmitter uptake (GO:0001504)6.59474409
3positive regulation of megakaryocyte differentiation (GO:0045654)5.85943247
4positive regulation of synaptic transmission, glutamatergic (GO:0051968)5.09267842
5positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.81779482
6glutamine metabolic process (GO:0006541)4.76738014
7glutamine family amino acid biosynthetic process (GO:0009084)4.54891418
8nerve growth factor signaling pathway (GO:0038180)4.46895060
9protein localization to cilium (GO:0061512)4.42225461
10intraciliary transport (GO:0042073)4.33764156
11response to pheromone (GO:0019236)4.14567343
12regulation of meiosis I (GO:0060631)4.13918664
13glutamate metabolic process (GO:0006536)3.98492058
14positive regulation of DNA-templated transcription, initiation (GO:2000144)3.97779681
15inositol metabolic process (GO:0006020)3.91956771
16replication fork processing (GO:0031297)3.81651002
17mechanosensory behavior (GO:0007638)3.80180094
18fucose catabolic process (GO:0019317)3.72909185
19L-fucose metabolic process (GO:0042354)3.72909185
20L-fucose catabolic process (GO:0042355)3.72909185
21interkinetic nuclear migration (GO:0022027)3.69774520
22negative regulation of macrophage differentiation (GO:0045650)3.67731455
23positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.63744946
24histone H2A acetylation (GO:0043968)3.63269982
25indole-containing compound catabolic process (GO:0042436)3.62763920
26indolalkylamine catabolic process (GO:0046218)3.62763920
27tryptophan catabolic process (GO:0006569)3.62763920
28snRNA processing (GO:0016180)3.51586746
29terpenoid biosynthetic process (GO:0016114)3.49730873
30regulation of centriole replication (GO:0046599)3.48931118
31glutamine family amino acid catabolic process (GO:0009065)3.44477614
32snRNA metabolic process (GO:0016073)3.39506515
33histone mRNA metabolic process (GO:0008334)3.38945152
34protein complex biogenesis (GO:0070271)3.38393524
35negative regulation of DNA-dependent DNA replication (GO:2000104)3.35619644
36mitotic recombination (GO:0006312)3.34496338
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.30124280
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.30124280
39NADH dehydrogenase complex assembly (GO:0010257)3.30124280
40isoprenoid biosynthetic process (GO:0008299)3.29531212
41regulation of timing of cell differentiation (GO:0048505)3.22753907
42positive regulation of developmental pigmentation (GO:0048087)3.20912463
43telomere maintenance via recombination (GO:0000722)3.17609114
44positive regulation of male gonad development (GO:2000020)3.16945560
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16636462
46kynurenine metabolic process (GO:0070189)3.16138505
47peripheral nervous system neuron development (GO:0048935)3.14413012
48mitochondrial respiratory chain complex assembly (GO:0033108)3.12792449
49negative regulation of nitric-oxide synthase activity (GO:0051001)3.12692426
50double-strand break repair via homologous recombination (GO:0000724)3.12257802
51aspartate family amino acid catabolic process (GO:0009068)3.10562019
52cellular response to exogenous dsRNA (GO:0071360)3.09696667
53recombinational repair (GO:0000725)3.09344233
54cilium or flagellum-dependent cell motility (GO:0001539)3.08233882
55maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.07976039
56cholesterol biosynthetic process (GO:0006695)3.04194210
57embryonic retina morphogenesis in camera-type eye (GO:0060059)3.00353709
58DNA damage induced protein phosphorylation (GO:0006975)2.98936115
59regulation of nuclear cell cycle DNA replication (GO:0033262)2.98931744
60regulation of male gonad development (GO:2000018)2.98437743
61postreplication repair (GO:0006301)2.98107006
62pseudouridine synthesis (GO:0001522)2.97785386
63DNA replication-dependent nucleosome assembly (GO:0006335)2.97551169
64DNA replication-dependent nucleosome organization (GO:0034723)2.97551169
65regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.97305887
66DNA strand renaturation (GO:0000733)2.96661503
67negative regulation of granulocyte differentiation (GO:0030853)2.91932023
68tryptophan metabolic process (GO:0006568)2.91731517
69neuronal stem cell maintenance (GO:0097150)2.91422295
70lysine metabolic process (GO:0006553)2.90799237
71lysine catabolic process (GO:0006554)2.90799237
72lens fiber cell development (GO:0070307)2.90707742
73nucleotide-excision repair, DNA gap filling (GO:0006297)2.87701718
74NAD biosynthetic process (GO:0009435)2.87143518
75snRNA transcription (GO:0009301)2.86443545
76meiotic chromosome segregation (GO:0045132)2.86397541
77regulation of development, heterochronic (GO:0040034)2.83129975
78regulation of DNA-templated transcription, initiation (GO:2000142)2.81586307
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81487346
80negative regulation of mast cell activation (GO:0033004)2.79501799
81indolalkylamine metabolic process (GO:0006586)2.75911031
82positive regulation of pseudopodium assembly (GO:0031274)2.75163387
83indole-containing compound metabolic process (GO:0042430)2.74763330
84telomere maintenance via semi-conservative replication (GO:0032201)2.73608816
85viral mRNA export from host cell nucleus (GO:0046784)2.71851095
86mechanoreceptor differentiation (GO:0042490)2.70281320
87regulation of centrosome cycle (GO:0046605)2.69693093
88serotonin metabolic process (GO:0042428)2.68288491
89cellular response to electrical stimulus (GO:0071257)2.67969848
90replicative senescence (GO:0090399)2.67594429
91positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.64204241
92auditory behavior (GO:0031223)2.63835940
93melanocyte differentiation (GO:0030318)2.63377643
94response to caffeine (GO:0031000)2.60117703
95regulation of developmental pigmentation (GO:0048070)2.56438925
96behavioral response to ethanol (GO:0048149)2.55324577
97termination of RNA polymerase II transcription (GO:0006369)2.54412488
98DNA deamination (GO:0045006)2.54276838
99regulation of centrosome duplication (GO:0010824)2.54158729
100mitochondrial fission (GO:0000266)2.52805414

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela5.21475718
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.20662261
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.52279374
4E2F7_22180533_ChIP-Seq_HELA_Human2.86690549
5VDR_22108803_ChIP-Seq_LS180_Human2.71825945
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64696538
7TAF15_26573619_Chip-Seq_HEK293_Human2.59124650
8IGF1R_20145208_ChIP-Seq_DFB_Human2.56177726
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.56132995
10EZH2_22144423_ChIP-Seq_EOC_Human2.53561746
11GATA1_22025678_ChIP-Seq_K562_Human2.43545060
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31254984
13EWS_26573619_Chip-Seq_HEK293_Human2.29354972
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21886173
15GBX2_23144817_ChIP-Seq_PC3_Human2.20256537
16IRF1_19129219_ChIP-ChIP_H3396_Human2.16871879
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10374905
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.04053506
19CBP_20019798_ChIP-Seq_JUKART_Human1.97773845
20IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.97773845
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97371669
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89330639
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84675203
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81483895
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80871769
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78944134
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77387335
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72924031
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.70866384
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.69239456
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.68585803
32FUS_26573619_Chip-Seq_HEK293_Human1.56293863
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56292478
34RNF2_27304074_Chip-Seq_NSC_Mouse1.55218643
35TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.53286344
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52322821
37TCF4_22108803_ChIP-Seq_LS180_Human1.52062078
38STAT3_23295773_ChIP-Seq_U87_Human1.51058835
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.49976477
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.48425109
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47002351
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43684423
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41397559
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39166038
45P300_19829295_ChIP-Seq_ESCs_Human1.38227132
46TCF4_23295773_ChIP-Seq_U87_Human1.38113951
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36193276
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.35754875
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32744378
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32478211
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31303787
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.30775216
53EGR1_19032775_ChIP-ChIP_M12_Human1.27010984
54FOXP3_21729870_ChIP-Seq_TREG_Human1.26891457
55TP53_22573176_ChIP-Seq_HFKS_Human1.26371217
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24839415
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.23693479
58MYC_18940864_ChIP-ChIP_HL60_Human1.23608526
59VDR_23849224_ChIP-Seq_CD4+_Human1.23420537
60AR_25329375_ChIP-Seq_VCAP_Human1.23326907
61TP53_16413492_ChIP-PET_HCT116_Human1.23286546
62SOX9_26525672_Chip-Seq_HEART_Mouse1.22810246
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21722636
64SMAD4_21799915_ChIP-Seq_A2780_Human1.17300151
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16086506
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16040480
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.15491070
68AR_20517297_ChIP-Seq_VCAP_Human1.13667543
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.12638784
70AR_21572438_ChIP-Seq_LNCaP_Human1.11720964
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09575880
72RUNX2_22187159_ChIP-Seq_PCA_Human1.08659660
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07215878
74ER_23166858_ChIP-Seq_MCF-7_Human1.06639218
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.06443319
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.06223838
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.05641579
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04756530
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04415219
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.04295125
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01327728
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00949991
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.00673581
84TBL1_22424771_ChIP-Seq_293T_Human1.00107388
85P53_22387025_ChIP-Seq_ESCs_Mouse1.00078316
86EST1_17652178_ChIP-ChIP_JURKAT_Human0.99086206
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98910915
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98461702
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97725918
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97633503
91NFYB_21822215_ChIP-Seq_K562_Human0.97341537
92ETV1_20927104_ChIP-Seq_GIST48_Human0.96853255
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95712845
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95451815
95SOX2_19829295_ChIP-Seq_ESCs_Human0.95240077
96NANOG_19829295_ChIP-Seq_ESCs_Human0.95240077
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94811462
98TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94611324
99KDM2B_26808549_Chip-Seq_REH_Human0.94509478
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94320719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.77970118
2MP0008057_abnormal_DNA_replication4.53334022
3MP0005174_abnormal_tail_pigmentation3.46769917
4MP0000372_irregular_coat_pigmentation3.46718085
5MP0001188_hyperpigmentation3.22726886
6MP0008058_abnormal_DNA_repair3.19993745
7MP0004133_heterotaxia3.16773106
8MP0003136_yellow_coat_color3.15828170
9MP0010094_abnormal_chromosome_stability2.69864360
10MP0002090_abnormal_vision2.56333875
11MP0002095_abnormal_skin_pigmentation2.48141958
12MP0003880_abnormal_central_pattern2.40517401
13MP0005187_abnormal_penis_morphology2.31418941
14MP0005646_abnormal_pituitary_gland2.21937737
15MP0003646_muscle_fatigue2.10875677
16MP0003119_abnormal_digestive_system2.03640840
17MP0004808_abnormal_hematopoietic_stem1.99787588
18MP0005075_abnormal_melanosome_morpholog1.99259212
19MP0009046_muscle_twitch1.90245387
20MP0001986_abnormal_taste_sensitivity1.83920846
21MP0005253_abnormal_eye_physiology1.80190407
22MP0004885_abnormal_endolymph1.77236427
23MP0008932_abnormal_embryonic_tissue1.73611680
24MP0002938_white_spotting1.72764413
25MP0000015_abnormal_ear_pigmentation1.59635231
26MP0002396_abnormal_hematopoietic_system1.58948080
27MP0002638_abnormal_pupillary_reflex1.56488980
28MP0005645_abnormal_hypothalamus_physiol1.56464377
29MP0002735_abnormal_chemical_nociception1.52205923
30MP0002751_abnormal_autonomic_nervous1.50452172
31MP0005171_absent_coat_pigmentation1.50104885
32MP0003937_abnormal_limbs/digits/tail_de1.44316572
33MP0006072_abnormal_retinal_apoptosis1.44003580
34MP0000647_abnormal_sebaceous_gland1.39993440
35MP0002102_abnormal_ear_morphology1.36064735
36MP0000631_abnormal_neuroendocrine_gland1.28516309
37MP0003385_abnormal_body_wall1.23923012
38MP0003943_abnormal_hepatobiliary_system1.21104070
39MP0003693_abnormal_embryo_hatching1.20231728
40MP0001545_abnormal_hematopoietic_system1.17523067
41MP0005397_hematopoietic_system_phenotyp1.17523067
42MP0003077_abnormal_cell_cycle1.15598599
43MP0005084_abnormal_gallbladder_morpholo1.14623871
44MP0005083_abnormal_biliary_tract1.14588612
45MP0003656_abnormal_erythrocyte_physiolo1.13299673
46MP0000566_synostosis1.11497431
47MP0004145_abnormal_muscle_electrophysio1.07536278
48MP0001529_abnormal_vocalization1.04665860
49MP0001764_abnormal_homeostasis1.04029959
50MP0006276_abnormal_autonomic_nervous1.03461959
51MP0008789_abnormal_olfactory_epithelium1.02234479
52MP0000465_gastrointestinal_hemorrhage0.99077127
53MP0000569_abnormal_digit_pigmentation0.97548484
54MP0001286_abnormal_eye_development0.96077389
55MP0003315_abnormal_perineum_morphology0.95293905
56MP0008877_abnormal_DNA_methylation0.94805546
57MP0004043_abnormal_pH_regulation0.93532589
58MP0001299_abnormal_eye_distance/0.93529164
59MP0000462_abnormal_digestive_system0.93417678
60MP0000516_abnormal_urinary_system0.92718441
61MP0005367_renal/urinary_system_phenotyp0.92718441
62MP0003786_premature_aging0.92309860
63MP0002877_abnormal_melanocyte_morpholog0.90176150
64MP0005248_abnormal_Harderian_gland0.89693891
65MP0005365_abnormal_bile_salt0.89395617
66MP0002184_abnormal_innervation0.88216589
67MP0001346_abnormal_lacrimal_gland0.85551873
68MP0002139_abnormal_hepatobiliary_system0.85473436
69MP0001765_abnormal_ion_homeostasis0.85271987
70MP0002075_abnormal_coat/hair_pigmentati0.81809630
71MP0008569_lethality_at_weaning0.77570274
72MP0005332_abnormal_amino_acid0.76832632
73MP0004142_abnormal_muscle_tone0.76036512
74MP0000538_abnormal_urinary_bladder0.75426896
75MP0001727_abnormal_embryo_implantation0.75308625
76MP0002269_muscular_atrophy0.75131343
77MP0005391_vision/eye_phenotype0.74564006
78MP0002210_abnormal_sex_determination0.74484643
79MP0003121_genomic_imprinting0.73967133
80MP0003195_calcinosis0.71467964
81MP0009703_decreased_birth_body0.70337185
82MP0000653_abnormal_sex_gland0.69601978
83MP0005369_muscle_phenotype0.69601303
84MP0000955_abnormal_spinal_cord0.68811587
85MP0002108_abnormal_muscle_morphology0.66487659
86MP0000026_abnormal_inner_ear0.66056838
87MP0008995_early_reproductive_senescence0.65459978
88MP0000371_diluted_coat_color0.64265345
89MP0002127_abnormal_cardiovascular_syste0.62401159
90MP0005394_taste/olfaction_phenotype0.61926982
91MP0005499_abnormal_olfactory_system0.61926982
92MP0002272_abnormal_nervous_system0.61458643
93MP0003137_abnormal_impulse_conducting0.60345574
94MP0005551_abnormal_eye_electrophysiolog0.60017304
95MP0002067_abnormal_sensory_capabilities0.59725982
96MP0000749_muscle_degeneration0.59433453
97MP0002837_dystrophic_cardiac_calcinosis0.58735167
98MP0009745_abnormal_behavioral_response0.57224985
99MP0005266_abnormal_metabolism0.56576751
100MP0002233_abnormal_nose_morphology0.55489024

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.70014941
2CNS hypomyelination (HP:0003429)4.37167234
3Type II lissencephaly (HP:0007260)4.08373136
4Cerebellar dysplasia (HP:0007033)3.85198398
5Abnormality of the periventricular white matter (HP:0002518)3.84340181
6Bradycardia (HP:0001662)3.73176247
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.44699153
8Abnormality of alanine metabolism (HP:0010916)3.44699153
9Hyperalaninemia (HP:0003348)3.44699153
10Severe global developmental delay (HP:0011344)3.42994307
11True hermaphroditism (HP:0010459)3.22800736
12Nephronophthisis (HP:0000090)3.15751184
13Tubular atrophy (HP:0000092)3.14607649
14Aplasia/Hypoplasia of the tibia (HP:0005772)3.02372026
15Severe muscular hypotonia (HP:0006829)3.00562001
16White forelock (HP:0002211)2.93730534
17Hypoplasia of the pons (HP:0012110)2.91681565
18Abnormality of the proximal phalanges of the hand (HP:0009834)2.85573193
19Synostosis involving the elbow (HP:0003938)2.81049860
20Humeroradial synostosis (HP:0003041)2.81049860
21Abnormal drinking behavior (HP:0030082)2.81003307
22Polydipsia (HP:0001959)2.81003307
23Popliteal pterygium (HP:0009756)2.74113234
24Pancreatic fibrosis (HP:0100732)2.72172521
25Hyperammonemia (HP:0001987)2.69075536
26Abnormality of the renal medulla (HP:0100957)2.62273519
27Fibular hypoplasia (HP:0003038)2.52152495
28Pancreatic cysts (HP:0001737)2.52124858
29Anterior segment dysgenesis (HP:0007700)2.47712569
30Congenital stationary night blindness (HP:0007642)2.47418588
31Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.46937627
32Short 1st metacarpal (HP:0010034)2.46937627
33Patchy hypopigmentation of hair (HP:0011365)2.46500315
34Aplasia/Hypoplasia of the patella (HP:0006498)2.42065104
35Delayed CNS myelination (HP:0002188)2.39218062
36Abnormality of the pons (HP:0007361)2.38060934
37Arthropathy (HP:0003040)2.37107006
38Tubulointerstitial nephritis (HP:0001970)2.34549473
39Short tibia (HP:0005736)2.28903776
40Deep palmar crease (HP:0006191)2.28837642
41Progressive inability to walk (HP:0002505)2.27644959
42Tubulointerstitial abnormality (HP:0001969)2.27003560
43Lissencephaly (HP:0001339)2.26065332
44Postaxial foot polydactyly (HP:0001830)2.24348251
45Aplasia/Hypoplasia of the fibula (HP:0006492)2.22301678
46Patellar aplasia (HP:0006443)2.21357169
47Hypoplasia of the capital femoral epiphysis (HP:0003090)2.18749300
48Decreased lacrimation (HP:0000633)2.18307703
49Fibular aplasia (HP:0002990)2.18126998
50Attenuation of retinal blood vessels (HP:0007843)2.17052605
51Congenital hepatic fibrosis (HP:0002612)2.16503252
52Abnormality of the 1st metacarpal (HP:0010009)2.11521206
53Medial flaring of the eyebrow (HP:0010747)2.08891696
54Abnormality of the renal cortex (HP:0011035)2.07443837
55Gonadal dysgenesis (HP:0000133)2.02999866
56Tubulointerstitial fibrosis (HP:0005576)2.02817205
57Death in infancy (HP:0001522)2.01540820
58Abnormal lung lobation (HP:0002101)1.99845276
59Supernumerary spleens (HP:0009799)1.99667877
60Meckel diverticulum (HP:0002245)1.99268564
61Hyperventilation (HP:0002883)1.96521602
62Inability to walk (HP:0002540)1.93512344
63Diaphragmatic weakness (HP:0009113)1.93018480
64Symphalangism affecting the phalanges of the hand (HP:0009773)1.92806181
65Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92011671
66Chromsome breakage (HP:0040012)1.91038069
67Spastic paraparesis (HP:0002313)1.88459799
68Polyuria (HP:0000103)1.88041390
69Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86656575
70Hypoplastic pelvis (HP:0008839)1.85378097
71Short hallux (HP:0010109)1.85211149
72Ectopic kidney (HP:0000086)1.85093997
73Abnormality of the ileum (HP:0001549)1.83530435
74Long nose (HP:0003189)1.82666193
75Aplasia/Hypoplasia of the hallux (HP:0008362)1.82502668
76Abnormal rod and cone electroretinograms (HP:0008323)1.82369403
77Optic nerve hypoplasia (HP:0000609)1.81885944
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.81548824
79Abnormality of chromosome stability (HP:0003220)1.79559858
80Sloping forehead (HP:0000340)1.78544407
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.76850735
82Abnormality of DNA repair (HP:0003254)1.74206010
83Adactyly (HP:0009776)1.73654002
84Postaxial hand polydactyly (HP:0001162)1.72474424
85Alacrima (HP:0000522)1.72304418
86Small hand (HP:0200055)1.72091609
87Short foot (HP:0001773)1.71016703
88Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.70531862
89Complete atrioventricular canal defect (HP:0001674)1.69870649
90Abnormal auditory evoked potentials (HP:0006958)1.69339397
91Recurrent corneal erosions (HP:0000495)1.69308312
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.68450532
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67384596
94Absent epiphyses (HP:0010577)1.67384596
95Abnormal sex determination (HP:0012244)1.67343135
96Sex reversal (HP:0012245)1.67343135
97Protruding tongue (HP:0010808)1.66530962
98Aplasia/hypoplasia of the humerus (HP:0006507)1.65115854
99Glioma (HP:0009733)1.64732988
100Congenital primary aphakia (HP:0007707)1.63379700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.30435631
2WNK43.90778314
3FRK3.52965883
4BRSK23.20758640
5STK392.88453384
6GRK12.87496359
7ZAK2.87224847
8MATK2.75675455
9BMPR1B2.71999219
10PNCK2.60287124
11STK162.44719590
12DAPK22.44639038
13BRAF2.23031451
14ADRBK21.90743455
15MKNK21.89724164
16SRPK11.88121520
17WNK11.83500895
18MKNK11.77110711
19KIT1.75654591
20WNK31.68980663
21ACVR1B1.67199948
22CAMK1G1.56917905
23CAMKK21.50249259
24TNIK1.41095357
25ITK1.37504476
26MAP2K21.32720489
27MAPK131.30112845
28TEC1.27877848
29JAK31.24112595
30ATR1.19818275
31MARK11.16053521
32RPS6KA51.14494469
33MAP4K21.13720075
34BRSK11.04795372
35NUAK10.96857197
36SGK20.90183363
37DYRK1A0.88294338
38DYRK30.85770537
39RPS6KA40.85311821
40WEE10.80829824
41PDGFRB0.79172847
42CDK30.77821493
43CCNB10.77443652
44STK38L0.76536208
45NME20.74052525
46CHEK20.72937113
47BCR0.71406228
48FER0.67966389
49CSNK1A1L0.67886478
50YES10.66842512
51TAOK30.66724724
52FGR0.65718406
53PAK30.63838463
54STK240.62945247
55FLT30.61521174
56ADRBK10.60889795
57MAP2K10.60518550
58BTK0.59603534
59PRKAA20.59215867
60NTRK30.58403714
61CSNK1G20.56874223
62PDGFRA0.54346864
63CSNK1G30.53986751
64MAP3K40.53808945
65OBSCN0.52165750
66ATM0.50740205
67SGK4940.50597082
68SGK2230.50597082
69TGFBR10.47176882
70MAP2K70.46731707
71SGK30.46518423
72PTK2B0.45201861
73NTRK20.44018787
74NEK90.41757686
75PRKCQ0.41743411
76CAMK10.41244452
77NME10.40745543
78MAP3K80.40480018
79PIK3CA0.40211305
80ABL10.39931827
81PAK60.39630293
82PRKD30.37701480
83ERBB20.37584803
84PIK3CG0.37344548
85PLK10.37153263
86PRKACA0.36227216
87CSNK1G10.36128180
88DYRK20.35764621
89MARK20.34509860
90CDK120.33226562
91PRKACB0.32872104
92PRKCE0.31309081
93IGF1R0.29648931
94AKT10.29043169
95CASK0.28815110
96CHEK10.28315618
97NTRK10.26349271
98GSK3B0.25761861
99TTK0.25047658
100CDK10.22984029

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009108.09140258
2Arginine biosynthesis_Homo sapiens_hsa002203.56640716
3Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002503.36670600
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.83197077
5Steroid biosynthesis_Homo sapiens_hsa001002.81542257
6DNA replication_Homo sapiens_hsa030302.60018132
7Fanconi anemia pathway_Homo sapiens_hsa034602.52262715
8Homologous recombination_Homo sapiens_hsa034402.46393136
9Fatty acid biosynthesis_Homo sapiens_hsa000612.37608924
10RNA polymerase_Homo sapiens_hsa030202.24149867
11Mismatch repair_Homo sapiens_hsa034302.18827816
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03276452
13Fatty acid elongation_Homo sapiens_hsa000621.89023806
14Protein export_Homo sapiens_hsa030601.77300447
15Butanoate metabolism_Homo sapiens_hsa006501.69318729
16Nucleotide excision repair_Homo sapiens_hsa034201.60586822
17Pyrimidine metabolism_Homo sapiens_hsa002401.57978836
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52311836
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48930366
20Regulation of autophagy_Homo sapiens_hsa041401.41849257
21One carbon pool by folate_Homo sapiens_hsa006701.40826968
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40528450
23Tryptophan metabolism_Homo sapiens_hsa003801.34584313
24Lysine degradation_Homo sapiens_hsa003101.24862779
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19690886
26Fatty acid metabolism_Homo sapiens_hsa012121.16218600
27Phototransduction_Homo sapiens_hsa047441.13475008
28Ether lipid metabolism_Homo sapiens_hsa005651.12493525
29Biosynthesis of amino acids_Homo sapiens_hsa012301.08785421
30GABAergic synapse_Homo sapiens_hsa047271.08399619
31p53 signaling pathway_Homo sapiens_hsa041151.07242035
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06960262
33Glutamatergic synapse_Homo sapiens_hsa047241.06726634
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06542540
35Purine metabolism_Homo sapiens_hsa002301.05164179
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98344878
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98301509
38RNA degradation_Homo sapiens_hsa030180.89597201
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87851033
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84664632
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83894868
42Linoleic acid metabolism_Homo sapiens_hsa005910.83625505
43Nicotine addiction_Homo sapiens_hsa050330.82814946
44Spliceosome_Homo sapiens_hsa030400.81649189
45Cell cycle_Homo sapiens_hsa041100.81635698
46RNA transport_Homo sapiens_hsa030130.78450794
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.76321065
48Non-homologous end-joining_Homo sapiens_hsa034500.76164362
49Peroxisome_Homo sapiens_hsa041460.75581290
50Base excision repair_Homo sapiens_hsa034100.75558989
51Selenocompound metabolism_Homo sapiens_hsa004500.75109866
52Ovarian steroidogenesis_Homo sapiens_hsa049130.74017089
53Alcoholism_Homo sapiens_hsa050340.72935850
54Propanoate metabolism_Homo sapiens_hsa006400.70319994
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70234227
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67692465
57Olfactory transduction_Homo sapiens_hsa047400.67568227
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65680768
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.64746901
60Metabolic pathways_Homo sapiens_hsa011000.60464138
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59866306
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58037863
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57645458
64Huntingtons disease_Homo sapiens_hsa050160.53794304
65Glutathione metabolism_Homo sapiens_hsa004800.52781117
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52207456
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49357086
68Basal transcription factors_Homo sapiens_hsa030220.48945208
69mRNA surveillance pathway_Homo sapiens_hsa030150.48788121
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44914571
71Long-term depression_Homo sapiens_hsa047300.43675807
72Systemic lupus erythematosus_Homo sapiens_hsa053220.43507149
73Taste transduction_Homo sapiens_hsa047420.43192908
74Oxidative phosphorylation_Homo sapiens_hsa001900.42738002
75Vitamin digestion and absorption_Homo sapiens_hsa049770.42402611
76Parkinsons disease_Homo sapiens_hsa050120.40814826
77Fatty acid degradation_Homo sapiens_hsa000710.39277104
78Melanoma_Homo sapiens_hsa052180.38159173
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37958230
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.37196813
81Sulfur relay system_Homo sapiens_hsa041220.33319006
82Acute myeloid leukemia_Homo sapiens_hsa052210.32410686
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31815351
84Histidine metabolism_Homo sapiens_hsa003400.30483997
85Glycerolipid metabolism_Homo sapiens_hsa005610.29363176
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29185881
87Insulin secretion_Homo sapiens_hsa049110.28390749
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28351072
89Arachidonic acid metabolism_Homo sapiens_hsa005900.28200031
90ABC transporters_Homo sapiens_hsa020100.26026320
91Thyroid cancer_Homo sapiens_hsa052160.21846001
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21618363
93Circadian entrainment_Homo sapiens_hsa047130.21338807
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.19942127
95Morphine addiction_Homo sapiens_hsa050320.19487720
96Prostate cancer_Homo sapiens_hsa052150.16949449
97Other glycan degradation_Homo sapiens_hsa005110.15159373
98Fat digestion and absorption_Homo sapiens_hsa049750.14890829
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.14747269
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13503600

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