SHOC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of protein glycosylation (GO:0060049)7.01626523
2positive regulation of glycoprotein biosynthetic process (GO:0010560)5.49804404
3activated T cell proliferation (GO:0050798)5.49764306
4neutrophil activation involved in immune response (GO:0002283)5.48473011
5positive regulation of glycoprotein metabolic process (GO:1903020)4.71967267
6mitotic sister chromatid cohesion (GO:0007064)4.17271823
7hippo signaling (GO:0035329)3.98115519
8neutrophil activation (GO:0042119)3.89163376
9nuclear pore complex assembly (GO:0051292)3.87944925
10acrosome assembly (GO:0001675)3.81171847
11heterotypic cell-cell adhesion (GO:0034113)3.76847535
12negative regulation of T-helper cell differentiation (GO:0045623)3.70872930
13negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.70872930
14NLS-bearing protein import into nucleus (GO:0006607)3.70311866
15cellular extravasation (GO:0045123)3.66676131
16negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.57324306
17COPI coating of Golgi vesicle (GO:0048205)3.48108051
18Golgi transport vesicle coating (GO:0048200)3.48108051
19protein targeting to Golgi (GO:0000042)3.43254278
20retrograde transport, vesicle recycling within Golgi (GO:0000301)3.41781176
21regulation of regulatory T cell differentiation (GO:0045589)3.40932099
22regulation of B cell receptor signaling pathway (GO:0050855)3.40775942
23cytoplasmic mRNA processing body assembly (GO:0033962)3.36338691
24leukocyte migration involved in inflammatory response (GO:0002523)3.35994590
25positive regulation of gamma-delta T cell activation (GO:0046645)3.35833620
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.33593876
27granulocyte activation (GO:0036230)3.33560823
28spermatid nucleus differentiation (GO:0007289)3.32275778
29glucocorticoid receptor signaling pathway (GO:0042921)3.32164187
30nuclear pore organization (GO:0006999)3.29289021
31nerve growth factor signaling pathway (GO:0038180)3.27244838
32negative regulation of execution phase of apoptosis (GO:1900118)3.25257528
33axon extension involved in axon guidance (GO:0048846)3.22067361
34neuron projection extension involved in neuron projection guidance (GO:1902284)3.22067361
35xenobiotic catabolic process (GO:0042178)3.20946638
36regulation of inositol phosphate biosynthetic process (GO:0010919)3.20322953
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.20048457
38regulation of transforming growth factor beta2 production (GO:0032909)3.04397336
39establishment of protein localization to Golgi (GO:0072600)3.02535898
40positive regulation of mast cell activation (GO:0033005)3.01424564
41embryonic body morphogenesis (GO:0010172)2.98613327
42positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.97521497
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97444055
44insulin-like growth factor receptor signaling pathway (GO:0048009)2.95134017
45microglial cell activation (GO:0001774)2.94359553
46regulation of glycoprotein biosynthetic process (GO:0010559)2.92767420
47regulation of T-helper 1 cell differentiation (GO:0045625)2.91602142
48negative regulation of interleukin-17 production (GO:0032700)2.89829089
49neutrophil chemotaxis (GO:0030593)2.88694276
50phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.87577044
51cell adhesion mediated by integrin (GO:0033627)2.86976122
52negative regulation of neurotransmitter transport (GO:0051589)2.85226715
53regulation of NFAT protein import into nucleus (GO:0051532)2.84546720
54interleukin-6-mediated signaling pathway (GO:0070102)2.83569944
55neutrophil migration (GO:1990266)2.81999999
56corticosteroid receptor signaling pathway (GO:0031958)2.81880386
57positive regulation of granulocyte differentiation (GO:0030854)2.79235580
58body morphogenesis (GO:0010171)2.78934337
59protein localization to cilium (GO:0061512)2.78920383
60chondrocyte development (GO:0002063)2.78588595
61positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.77747042
62positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.77747042
63positive regulation of mitotic sister chromatid separation (GO:1901970)2.77747042
64pore complex assembly (GO:0046931)2.76854274
65myeloid leukocyte mediated immunity (GO:0002444)2.73976731
66artery development (GO:0060840)2.73698717
67neutrophil mediated immunity (GO:0002446)2.72539588
68leukocyte cell-cell adhesion (GO:0007159)2.72280716
69detection of molecule of bacterial origin (GO:0032490)2.71781549
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.71674629
71negative regulation of cell killing (GO:0031342)2.71674629
72negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.67934736
73negative regulation of B cell proliferation (GO:0030889)2.67919477
74B cell receptor signaling pathway (GO:0050853)2.66892055
75granulocyte chemotaxis (GO:0071621)2.66105178
76dendritic cell migration (GO:0036336)2.63961156
77branching involved in prostate gland morphogenesis (GO:0060442)2.63671041
78negative regulation of fatty acid transport (GO:2000192)2.61411328
79regulation of clathrin-mediated endocytosis (GO:2000369)2.60487472
80regulation of Golgi to plasma membrane protein transport (GO:0042996)2.60467532
81positive regulation of alpha-beta T cell proliferation (GO:0046641)2.59812492
82axon extension (GO:0048675)2.58699927
83cellular response to interferon-alpha (GO:0035457)2.58385298
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.57327257
85granulocyte migration (GO:0097530)2.56094808
86positive regulation of T cell cytokine production (GO:0002726)2.55629270
87histamine secretion (GO:0001821)2.54664550
88tyrosine phosphorylation of STAT protein (GO:0007260)2.54332207
89protein K11-linked deubiquitination (GO:0035871)2.53626720
90regulation of mast cell activation (GO:0033003)2.50607840
91response to interleukin-15 (GO:0070672)2.49441100
92definitive hemopoiesis (GO:0060216)2.48911973
93regulation of germinal center formation (GO:0002634)2.48534091
94positive regulation of cardiac muscle cell differentiation (GO:2000727)2.48386374
95SMAD protein complex assembly (GO:0007183)2.48269633
96anatomical structure arrangement (GO:0048532)2.48116363
97gastrulation with mouth forming second (GO:0001702)2.47982118
98antigen processing and presentation of endogenous antigen (GO:0019883)2.47377263
99necroptotic process (GO:0070266)2.46920422
100negative regulation of interleukin-12 production (GO:0032695)2.46647560
101protein localization to microtubule cytoskeleton (GO:0072698)2.46318527
102regulation of DNA endoreduplication (GO:0032875)2.46305435
103ganglion development (GO:0061548)2.46050656
104regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.45443938
105neural crest cell development (GO:0014032)2.45397611
106myeloid cell activation involved in immune response (GO:0002275)2.44883773
107phosphatidylinositol acyl-chain remodeling (GO:0036149)2.42737892
108negative regulation of alpha-beta T cell differentiation (GO:0046639)2.42620869
109chondrocyte proliferation (GO:0035988)2.42476135
110cellular response to interleukin-15 (GO:0071350)2.41944226
111response to nitrosative stress (GO:0051409)2.41891487
112negative regulation of neurotransmitter secretion (GO:0046929)2.41850541
113cellular response to ethanol (GO:0071361)2.41840280
114negative regulation of immunoglobulin mediated immune response (GO:0002890)2.41732058
115negative regulation of B cell mediated immunity (GO:0002713)2.41732058
116interferon-gamma production (GO:0032609)2.40909238
117regulation of memory T cell differentiation (GO:0043380)2.40464802
118protein localization to Golgi apparatus (GO:0034067)2.40305815
119vesicle coating (GO:0006901)2.39274875
120dendritic cell chemotaxis (GO:0002407)2.38962012
121macrophage activation involved in immune response (GO:0002281)2.38154835
122dorsal/ventral axis specification (GO:0009950)2.38045610
123regulation of fibroblast migration (GO:0010762)2.37908950
124heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.37570247
125layer formation in cerebral cortex (GO:0021819)2.37500767
126negative regulation of exocytosis (GO:0045920)2.37272030
127mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.37172146
128positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.37172146
129sequestering of extracellular ligand from receptor (GO:0035581)2.36885975
130regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.36430131
131negative regulation of adaptive immune response (GO:0002820)2.36093750
132regulation of glycoprotein metabolic process (GO:1903018)2.36002385
133lymphangiogenesis (GO:0001946)2.35719827
134regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.34950088
135positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.34751198
136regulation of lipoprotein metabolic process (GO:0050746)2.34297272
137relaxation of cardiac muscle (GO:0055119)2.33529956
138positive regulation of interleukin-1 beta secretion (GO:0050718)2.33479265
139positive regulation of vesicle fusion (GO:0031340)2.33380768
140negative chemotaxis (GO:0050919)2.33308023
141positive regulation of muscle hypertrophy (GO:0014742)2.32656778
142positive regulation of cardiac muscle hypertrophy (GO:0010613)2.32656778
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.32450222
144neuron projection extension (GO:1990138)2.32101368
145protein localization to cytoskeleton (GO:0044380)2.30641329
146cell migration involved in sprouting angiogenesis (GO:0002042)2.30077960
147histone mRNA catabolic process (GO:0071044)2.29848673
148negative regulation of DNA repair (GO:0045738)2.29602572
149regulation of protein polyubiquitination (GO:1902914)2.27608998
150cellular response to vitamin D (GO:0071305)2.26606046
151negative regulation of keratinocyte proliferation (GO:0010839)2.24713739
152pre-miRNA processing (GO:0031054)2.22529214
153substrate-dependent cell migration (GO:0006929)2.21168408
154regulation of RNA export from nucleus (GO:0046831)2.18744010
155positive regulation of axon extension (GO:0045773)2.18098660
156positive regulation of actin filament depolymerization (GO:0030836)2.17573829
157regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.16955032
158embryonic foregut morphogenesis (GO:0048617)2.16815985
159hepatocyte apoptotic process (GO:0097284)2.16624339
160mesenchymal-epithelial cell signaling (GO:0060638)2.15811491
161retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.15402341
162embryonic viscerocranium morphogenesis (GO:0048703)2.15274932
163protein localization to microtubule (GO:0035372)2.13536505
164embryonic camera-type eye morphogenesis (GO:0048596)2.13473350
165regulation of centriole replication (GO:0046599)2.12967720
166neural tube formation (GO:0001841)2.12453729
167wound healing, spreading of epidermal cells (GO:0035313)2.11539599
168dopaminergic neuron differentiation (GO:0071542)2.11027520
169regulation of axon extension involved in axon guidance (GO:0048841)2.09982637
170craniofacial suture morphogenesis (GO:0097094)2.09952548
171cellular response to prostaglandin stimulus (GO:0071379)2.09372869
172growth hormone receptor signaling pathway (GO:0060396)2.09331280
173regulation of Rac protein signal transduction (GO:0035020)2.09290295
174dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.09065711
175interkinetic nuclear migration (GO:0022027)2.07049079
176collagen fibril organization (GO:0030199)2.05214392
177positive regulation of osteoblast differentiation (GO:0045669)2.05161902
178embryonic process involved in female pregnancy (GO:0060136)2.04242196
179histone H2A monoubiquitination (GO:0035518)2.03438818
180synaptic vesicle docking involved in exocytosis (GO:0016081)2.02324582
181regulation of cell fate specification (GO:0042659)2.01649357
182positive regulation of protein export from nucleus (GO:0046827)2.01131077
183exocrine pancreas development (GO:0031017)2.01122181
184mesenchymal cell development (GO:0014031)2.00891927
185response to UV-C (GO:0010225)2.00659085
186germ cell migration (GO:0008354)2.00486807
187sympathetic nervous system development (GO:0048485)2.00177307
188cytoskeleton-dependent cytokinesis (GO:0061640)1.98461884
189endodermal cell differentiation (GO:0035987)1.98399505
190dendrite morphogenesis (GO:0048813)1.98253422

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.53200015
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.42743630
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.38343083
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23488615
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.86910832
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.82768287
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64018329
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.57044483
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.50567165
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.30631341
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.30243317
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.26692493
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03703634
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.03645184
15GATA1_22025678_ChIP-Seq_K562_Human1.99831365
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98933703
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.98587065
18TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.94190921
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93378533
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92046290
21TP53_16413492_ChIP-PET_HCT116_Human1.87780343
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86433942
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85427664
24AR_21572438_ChIP-Seq_LNCaP_Human1.85068365
25EZH2_27294783_Chip-Seq_NPCs_Mouse1.83078000
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76104376
27GBX2_23144817_ChIP-Seq_PC3_Human1.75223102
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.74197231
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.71330415
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.71250753
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69356603
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.68297500
33* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.67776262
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67151233
35FUS_26573619_Chip-Seq_HEK293_Human1.66767753
36IGF1R_20145208_ChIP-Seq_DFB_Human1.66694132
37RUNX_20019798_ChIP-Seq_JUKART_Human1.65712234
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.65027738
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.64030040
40VDR_22108803_ChIP-Seq_LS180_Human1.63822050
41* BRD4_25478319_ChIP-Seq_HGPS_Human1.62986484
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61280065
43SMAD4_21799915_ChIP-Seq_A2780_Human1.60517460
44P300_19829295_ChIP-Seq_ESCs_Human1.60401359
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59975541
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.58424666
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57162308
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54761091
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54761091
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54468108
51TP53_18474530_ChIP-ChIP_U2OS_Human1.53080295
52CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.52325090
53BCAT_22108803_ChIP-Seq_LS180_Human1.50911507
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50826582
55CJUN_26792858_Chip-Seq_BT549_Human1.49826567
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48266788
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.48076187
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47396072
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47210453
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.45624945
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45541901
62P53_22387025_ChIP-Seq_ESCs_Mouse1.45267202
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43203756
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42474345
65CBP_20019798_ChIP-Seq_JUKART_Human1.42474345
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42397535
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.41660107
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.40632564
69OCT4_21477851_ChIP-Seq_ESCs_Mouse1.40396921
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38710562
71RXR_22108803_ChIP-Seq_LS180_Human1.37935184
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.37232957
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36867357
74FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36775222
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.35561144
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35364268
77EWS_26573619_Chip-Seq_HEK293_Human1.35317223
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34696016
79TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32962827
80IRF8_27001747_Chip-Seq_BMDM_Mouse1.32639251
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.32397346
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.32280558
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32068597
84AHR_22903824_ChIP-Seq_MCF-7_Human1.31960068
85* STAT3_23295773_ChIP-Seq_U87_Human1.30323636
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29354844
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29030078
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29009841
89PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28910396
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27333828
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27179540
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26918090
93TAF15_26573619_Chip-Seq_HEK293_Human1.26532731
94AR_25329375_ChIP-Seq_VCAP_Human1.25862302
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25255499
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.24587098
97GATA3_26560356_Chip-Seq_TH2_Human1.24199030
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.23824804
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22464313
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.21958666
101STAT3_18555785_Chip-Seq_ESCs_Mouse1.20506704
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.20415902
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19865245
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19086741
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18686007
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18686007
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18610798
108* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18567551
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.17927021
110ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17314860
111EZH2_22144423_ChIP-Seq_EOC_Human1.17008992
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15552155
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15436298
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.15107306
115* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15025244
116OCT4_18555785_Chip-Seq_ESCs_Mouse1.13758066
117SMAD3_21741376_ChIP-Seq_EPCs_Human1.13593538
118CLOCK_20551151_ChIP-Seq_293T_Human1.13140418
119CDX2_22108803_ChIP-Seq_LS180_Human1.11924530
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11428899
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10973846
122Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09709474
123P300_18555785_Chip-Seq_ESCs_Mouse1.09452572
124NMYC_18555785_Chip-Seq_ESCs_Mouse1.09185505
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.08447883
126ISL1_27105846_Chip-Seq_CPCs_Mouse1.08422447
127MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07805815
128TP63_17297297_ChIP-ChIP_HaCaT_Human1.07750043
129* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06887732
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06708655
131AR_19668381_ChIP-Seq_PC3_Human1.06693831
132FOXO3_23340844_ChIP-Seq_DLD1_Human1.06646894
133ZNF274_21170338_ChIP-Seq_K562_Hela1.06599050
134SOX2_19829295_ChIP-Seq_ESCs_Human1.05706515
135NANOG_19829295_ChIP-Seq_ESCs_Human1.05706515
136* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04943632
137NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04418568
138SALL4_22934838_ChIP-ChIP_CD34+_Human1.04321985
139VDR_24787735_ChIP-Seq_THP-1_Human1.03985480
140TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03357922
141ER_23166858_ChIP-Seq_MCF-7_Human1.03352191
142TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02319679
143NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01200996
144RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00939215
145TCF4_23295773_ChIP-Seq_U87_Human1.00459147
146RUNX2_22187159_ChIP-Seq_PCA_Human0.96534799
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95964973
148SOX2_20726797_ChIP-Seq_SW620_Human0.95944724
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95587733
150RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95481244
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94820896
152TCF4_22108803_ChIP-Seq_LS180_Human0.93718353
153TP63_23658742_ChIP-Seq_EP156T_Human0.92018384
154* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91187021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.54689560
2MP0010352_gastrointestinal_tract_polyps4.02339272
3MP0003705_abnormal_hypodermis_morpholog3.21039337
4MP0009780_abnormal_chondrocyte_physiolo3.16388071
5MP0000569_abnormal_digit_pigmentation3.02746013
6MP0005076_abnormal_cell_differentiation3.02732631
7MP0010234_abnormal_vibrissa_follicle2.93676997
8MP0001835_abnormal_antigen_presentation2.91602548
9MP0005248_abnormal_Harderian_gland2.75365968
10MP0000516_abnormal_urinary_system2.68634984
11MP0005367_renal/urinary_system_phenotyp2.68634984
12MP0003890_abnormal_embryonic-extraembry2.68238648
13MP0001851_eye_inflammation2.64207368
14MP0005187_abnormal_penis_morphology2.55748340
15MP0003195_calcinosis2.51594579
16MP0008260_abnormal_autophagy2.50992292
17MP0005464_abnormal_platelet_physiology2.49697195
18MP0008877_abnormal_DNA_methylation2.42089768
19MP0000465_gastrointestinal_hemorrhage2.35277400
20MP0009053_abnormal_anal_canal2.29941831
21MP0005000_abnormal_immune_tolerance2.29904093
22MP0005671_abnormal_response_to2.19440490
23MP0001800_abnormal_humoral_immune2.16252490
24MP0003183_abnormal_peptide_metabolism2.13316722
25MP0005275_abnormal_skin_tensile2.12097001
26MP0002877_abnormal_melanocyte_morpholog2.09495412
27MP0003300_gastrointestinal_ulcer2.08698076
28MP0010386_abnormal_urinary_bladder2.08282308
29MP0006082_CNS_inflammation2.02547205
30MP0003787_abnormal_imprinting2.02184529
31MP0005503_abnormal_tendon_morphology2.01860971
32MP0004484_altered_response_of1.87330546
33MP0002896_abnormal_bone_mineralization1.85144243
34MP0002723_abnormal_immune_serum1.85051012
35MP0003385_abnormal_body_wall1.82927481
36MP0003121_genomic_imprinting1.75508755
37MP0002419_abnormal_innate_immunity1.74603485
38MP0001299_abnormal_eye_distance/1.73563041
39MP0000537_abnormal_urethra_morphology1.71470893
40MP0000427_abnormal_hair_cycle1.71232661
41MP0002452_abnormal_antigen_presenting1.69070729
42MP0002148_abnormal_hypersensitivity_rea1.65874623
43MP0006054_spinal_hemorrhage1.65784902
44MP0010030_abnormal_orbit_morphology1.61657281
45MP0002933_joint_inflammation1.61015159
46MP0005025_abnormal_response_to1.56531825
47MP0005174_abnormal_tail_pigmentation1.55204966
48MP0009384_cardiac_valve_regurgitation1.54930100
49MP0009785_altered_susceptibility_to1.54654744
50MP0003122_maternal_imprinting1.53361663
51MP0003091_abnormal_cell_migration1.53076127
52MP0004947_skin_inflammation1.50784648
53MP0004272_abnormal_basement_membrane1.50326814
54MP0003763_abnormal_thymus_physiology1.50068588
55MP0008438_abnormal_cutaneous_collagen1.49422359
56MP0003566_abnormal_cell_adhesion1.49037380
57MP0003828_pulmonary_edema1.48139597
58MP0002420_abnormal_adaptive_immunity1.45003145
59MP0003656_abnormal_erythrocyte_physiolo1.42994189
60MP0005387_immune_system_phenotype1.41749057
61MP0001790_abnormal_immune_system1.41749057
62MP0003011_delayed_dark_adaptation1.41022920
63MP0001845_abnormal_inflammatory_respons1.40821887
64MP0001346_abnormal_lacrimal_gland1.40783600
65MP0008004_abnormal_stomach_pH1.40716852
66MP0003123_paternal_imprinting1.40534846
67MP0001819_abnormal_immune_cell1.39550164
68MP0005253_abnormal_eye_physiology1.39151098
69MP0005408_hypopigmentation1.38033446
70MP0005386_behavior/neurological_phenoty1.37913640
71MP0004924_abnormal_behavior1.37913640
72MP0005075_abnormal_melanosome_morpholog1.35677837
73MP0000689_abnormal_spleen_morphology1.33455970
74MP0009250_abnormal_appendicular_skeleto1.32412381
75MP0002009_preneoplasia1.32278464
76MP0005623_abnormal_meninges_morphology1.32274663
77MP0003755_abnormal_palate_morphology1.30973024
78MP0002398_abnormal_bone_marrow1.30316447
79MP0010307_abnormal_tumor_latency1.29199393
80MP0000685_abnormal_immune_system1.27533621
81MP0000230_abnormal_systemic_arterial1.26374275
82MP0002405_respiratory_system_inflammati1.22509903
83MP0008057_abnormal_DNA_replication1.22073137
84MP0002006_tumorigenesis1.20605566
85MP0000015_abnormal_ear_pigmentation1.20131168
86MP0000716_abnormal_immune_system1.19285748
87MP0010678_abnormal_skin_adnexa1.17257359
88MP0003866_abnormal_defecation1.17164407
89MP0002166_altered_tumor_susceptibility1.16960509
90MP0003937_abnormal_limbs/digits/tail_de1.16395788
91MP0010155_abnormal_intestine_physiology1.15553734
92MP0003646_muscle_fatigue1.13162029
93MP0003935_abnormal_craniofacial_develop1.11180655
94MP0000534_abnormal_ureter_morphology1.10643929
95MP0005310_abnormal_salivary_gland1.10640334
96MP0002722_abnormal_immune_system1.09415253
97MP0004197_abnormal_fetal_growth/weight/1.09241391
98MP0010368_abnormal_lymphatic_system1.08855189
99MP0000733_abnormal_muscle_development1.08758701
100MP0002876_abnormal_thyroid_physiology1.08558455
101MP0003942_abnormal_urinary_system1.07729255
102MP0004264_abnormal_extraembryonic_tissu1.07392328
103MP0003941_abnormal_skin_development1.06359702
104MP0000428_abnormal_craniofacial_morphol1.06178917
105MP0000432_abnormal_head_morphology1.06010192
106* MP0001191_abnormal_skin_condition1.05891526
107MP0000538_abnormal_urinary_bladder1.05665403
108MP0003303_peritoneal_inflammation1.04222141
109MP0000579_abnormal_nail_morphology1.04211159
110MP0004233_abnormal_muscle_weight1.02098213
111MP0001879_abnormal_lymphatic_vessel1.01243906
112MP0000013_abnormal_adipose_tissue1.00596242
113MP0009703_decreased_birth_body1.00397070
114MP0008789_abnormal_olfactory_epithelium1.00080447
115MP0002102_abnormal_ear_morphology0.99621290
116MP0002086_abnormal_extraembryonic_tissu0.99272911
117MP0002115_abnormal_skeleton_extremities0.97164574
118MP0005197_abnormal_uvea_morphology0.96623770
119MP0009765_abnormal_xenobiotic_induced0.96327436
120MP0003119_abnormal_digestive_system0.94588255
121MP0003172_abnormal_lysosome_physiology0.94501991
122MP0000383_abnormal_hair_follicle0.93654767
123MP0008469_abnormal_protein_level0.93423900
124MP0002277_abnormal_respiratory_mucosa0.93153294
125MP0004142_abnormal_muscle_tone0.91784557
126MP0002233_abnormal_nose_morphology0.91545729
127MP0002098_abnormal_vibrissa_morphology0.91236035
128MP0000163_abnormal_cartilage_morphology0.90432241
129MP0008872_abnormal_physiological_respon0.90159322
130MP0002177_abnormal_outer_ear0.90037627
131MP0005645_abnormal_hypothalamus_physiol0.89629227
132MP0002971_abnormal_brown_adipose0.89366457
133MP0002084_abnormal_developmental_patter0.89353591
134MP0009764_decreased_sensitivity_to0.88933720
135MP0001529_abnormal_vocalization0.88511721
136MP0002822_catalepsy0.88325001
137MP0004858_abnormal_nervous_system0.88207718
138MP0006072_abnormal_retinal_apoptosis0.88151425
139MP0004510_myositis0.88106793
140MP0005257_abnormal_intraocular_pressure0.88104493
141MP0003045_fibrosis0.87862495
142MP0002109_abnormal_limb_morphology0.87617679
143MP0002113_abnormal_skeleton_development0.87526659
144* MP0002925_abnormal_cardiovascular_devel0.87079565
145MP0002116_abnormal_craniofacial_bone0.83910974
146MP0001727_abnormal_embryo_implantation0.83593185
147MP0002282_abnormal_trachea_morphology0.83473576
148MP0003115_abnormal_respiratory_system0.83106685
149MP0002160_abnormal_reproductive_system0.82999509
150MP0005389_reproductive_system_phenotype0.82655193
151MP0001177_atelectasis0.82288212
152MP0002429_abnormal_blood_cell0.82193300
153* MP0002088_abnormal_embryonic_growth/wei0.81877037
154MP0000703_abnormal_thymus_morphology0.81716647
155MP0000627_abnormal_mammary_gland0.81632448
156MP0002332_abnormal_exercise_endurance0.80606745
157MP0005508_abnormal_skeleton_morphology0.80066914
158* MP0003984_embryonic_growth_retardation0.79194675
159MP0005410_abnormal_fertilization0.78437177
160MP0005595_abnormal_vascular_smooth0.78436571
161MP0003436_decreased_susceptibility_to0.78083774
162MP0001340_abnormal_eyelid_morphology0.78058153
163MP0001286_abnormal_eye_development0.77899177
164MP0004885_abnormal_endolymph0.77809494
165MP0008873_increased_physiological_sensi0.77279494
166MP0000647_abnormal_sebaceous_gland0.76964082
167MP0002697_abnormal_eye_size0.76804416
168MP0006035_abnormal_mitochondrial_morpho0.76455672
169MP0003690_abnormal_glial_cell0.75467251
170MP0005084_abnormal_gallbladder_morpholo0.75436215
171MP0001915_intracranial_hemorrhage0.75173223
172MP0005164_abnormal_response_to0.75088306
173MP0005023_abnormal_wound_healing0.74854067
174MP0002693_abnormal_pancreas_physiology0.74708502
175MP0001188_hyperpigmentation0.73209369
176MP0002095_abnormal_skin_pigmentation0.72443768
177MP0005397_hematopoietic_system_phenotyp0.70473013
178* MP0005380_embryogenesis_phenotype0.69874695
179* MP0001672_abnormal_embryogenesis/_devel0.69874695
180MP0002168_other_aberrant_phenotype0.69114813
181MP0004883_abnormal_blood_vessel0.67629435
182MP0005499_abnormal_olfactory_system0.64037388
183MP0005394_taste/olfaction_phenotype0.64037388

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)6.85004061
2Recurrent abscess formation (HP:0002722)5.68908375
3Periodontitis (HP:0000704)5.36649098
4Leukocytosis (HP:0001974)4.53136629
5Autoimmune hemolytic anemia (HP:0001890)4.48626295
6Gingivitis (HP:0000230)4.05013976
7Abnormality of the nasal septum (HP:0000419)3.78914960
8Eosinophilia (HP:0001880)3.75062333
9Asymmetry of the thorax (HP:0001555)3.73935769
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.56716577
11Stomatitis (HP:0010280)3.52222723
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.50066933
13Short 4th metacarpal (HP:0010044)3.50066933
14Volvulus (HP:0002580)3.39476229
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.39085593
16Abnormality of T cell number (HP:0011839)3.35529114
17Prolonged bleeding time (HP:0003010)3.19131407
18Autoimmune thrombocytopenia (HP:0001973)3.16152836
19Abnormality of eosinophils (HP:0001879)3.03836275
20Thyroiditis (HP:0100646)2.92644152
21Hypoproteinemia (HP:0003075)2.91589490
22Increased mean platelet volume (HP:0011877)2.81512760
23Optic neuritis (HP:0100653)2.79962831
24Retrobulbar optic neuritis (HP:0100654)2.79962831
25Abnormal platelet volume (HP:0011876)2.76658990
26Granulocytopenia (HP:0001913)2.76616562
27Facial diplegia (HP:0001349)2.75990600
28Abnormality of macular pigmentation (HP:0008002)2.75763630
29Hypoplastic labia majora (HP:0000059)2.74494461
30Abnormality of the 4th metacarpal (HP:0010012)2.67225827
31Progressive inability to walk (HP:0002505)2.65360857
32Shallow orbits (HP:0000586)2.62823879
33Recurrent bacterial skin infections (HP:0005406)2.61810050
34Chronic bronchitis (HP:0004469)2.56904991
35Absent frontal sinuses (HP:0002688)2.55905249
36Subacute progressive viral hepatitis (HP:0006572)2.53967403
37Panhypogammaglobulinemia (HP:0003139)2.50602704
38Papillary thyroid carcinoma (HP:0002895)2.49865404
39Macroorchidism (HP:0000053)2.48168747
40Attenuation of retinal blood vessels (HP:0007843)2.45740170
41Abnormality of the labia majora (HP:0012881)2.43961075
42Pulmonary embolism (HP:0002204)2.43465415
43Eczematoid dermatitis (HP:0000976)2.40748769
44Aortic aneurysm (HP:0004942)2.40452331
45Chorioretinal atrophy (HP:0000533)2.39650398
46Cortical dysplasia (HP:0002539)2.34916787
47Hepatoblastoma (HP:0002884)2.34411136
48Bladder neoplasm (HP:0009725)2.34123415
49Bladder carcinoma (HP:0002862)2.34123415
50Vasculitis (HP:0002633)2.33634503
51Gingival bleeding (HP:0000225)2.32576650
52Transitional cell carcinoma of the bladder (HP:0006740)2.30782613
53Increased IgM level (HP:0003496)2.30274435
54T lymphocytopenia (HP:0005403)2.29642630
55Gaze-evoked nystagmus (HP:0000640)2.28946440
56Microcytic anemia (HP:0001935)2.28651051
57Epistaxis (HP:0000421)2.27748176
58Increased number of teeth (HP:0011069)2.26330325
59Orchitis (HP:0100796)2.24644194
60Overgrowth (HP:0001548)2.23741375
61Encephalitis (HP:0002383)2.21287776
62Rectal prolapse (HP:0002035)2.20782110
63Hematochezia (HP:0002573)2.20698111
64Lip pit (HP:0100267)2.17608485
65Protrusio acetabuli (HP:0003179)2.17533267
66Abnormality of the renal cortex (HP:0011035)2.13672326
67Abnormality of T cell physiology (HP:0011840)2.13456384
68Abnormality of B cell number (HP:0010975)2.13440233
69Aqueductal stenosis (HP:0002410)2.13313739
70Neoplasm of the tracheobronchial system (HP:0100552)2.11965836
71Abnormality of the prostate (HP:0008775)2.11899284
72Biliary tract neoplasm (HP:0100574)2.08703837
73Renal cortical cysts (HP:0000803)2.08329428
74Malignant gastrointestinal tract tumors (HP:0006749)2.08048475
75Gastrointestinal carcinoma (HP:0002672)2.08048475
76Medial flaring of the eyebrow (HP:0010747)2.07583197
77B lymphocytopenia (HP:0010976)2.07252563
78Broad thumb (HP:0011304)2.07098534
79Spontaneous hematomas (HP:0007420)2.06329989
80Enlarged penis (HP:0000040)2.05644759
81Petechiae (HP:0000967)2.05437761
82Thyroid carcinoma (HP:0002890)2.04187938
83Microglossia (HP:0000171)2.03742585
84Wrist flexion contracture (HP:0001239)2.01862439
85Colon cancer (HP:0003003)2.01617110
86Syringomyelia (HP:0003396)2.00126496
87Spinal cord lesions (HP:0100561)2.00126496
88Myositis (HP:0100614)1.99836357
89Rhinitis (HP:0012384)1.99184873
90Exostoses (HP:0100777)1.99151673
91Keratoconjunctivitis sicca (HP:0001097)1.98517112
92Abnormality of T cells (HP:0002843)1.98341696
93Amyotrophic lateral sclerosis (HP:0007354)1.97563528
94Hypothermia (HP:0002045)1.95012912
95Inappropriate behavior (HP:0000719)1.94732222
96Alveolar cell carcinoma (HP:0006519)1.94412728
97Narrow palate (HP:0000189)1.94234900
98Neoplasm of the adrenal cortex (HP:0100641)1.93726052
99Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.93664718
100Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.92938611
101Ankyloglossia (HP:0010296)1.92108403
102Recurrent fungal infections (HP:0002841)1.92051574
103Deviation of the thumb (HP:0009603)1.90532229
104Cone-rod dystrophy (HP:0000548)1.90016810
105Abnormal respiratory motile cilium physiology (HP:0012261)1.89358360
106Genetic anticipation (HP:0003743)1.89252557
107Increased density of long bones (HP:0006392)1.88977181
108Abnormality of the frontal sinuses (HP:0002687)1.88433214
109Uterine neoplasm (HP:0010784)1.88077878
110Aplasia cutis congenita (HP:0001057)1.87610797
111Keratoconjunctivitis (HP:0001096)1.86467360
1123-Methylglutaconic aciduria (HP:0003535)1.86307488
113Febrile seizures (HP:0002373)1.85746074
114Abnormality of the distal phalanx of the thumb (HP:0009617)1.85253364
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84987029
116Tracheomalacia (HP:0002779)1.84693474
117Broad ribs (HP:0000885)1.84425615
118Meningitis (HP:0001287)1.83652262
119Midline defect of the nose (HP:0004122)1.83356287
120Trigonocephaly (HP:0000243)1.82725507
121Bronchitis (HP:0012387)1.82406178
122Hypoplastic ischia (HP:0003175)1.81273260
123Gangrene (HP:0100758)1.80831813
124Mitral valve prolapse (HP:0001634)1.80438873
125Gastrointestinal infarctions (HP:0005244)1.79989321
126* Deep philtrum (HP:0002002)1.79943785
127Pulmonary infiltrates (HP:0002113)1.79651702
128Dilatation of the ascending aorta (HP:0005111)1.79493313
129Labial hypoplasia (HP:0000066)1.79312490
130Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.79265253
131Arterial tortuosity (HP:0005116)1.79088812
132Hemiplegia (HP:0002301)1.78294967
133Fibular aplasia (HP:0002990)1.77067603
134Hemoptysis (HP:0002105)1.76625558
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75736507
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.75736507
137Chronic otitis media (HP:0000389)1.75639090
138Uterine leiomyosarcoma (HP:0002891)1.75635842
139Leiomyosarcoma (HP:0100243)1.75635842
140Truncal obesity (HP:0001956)1.74608773
141Arterial thrombosis (HP:0004420)1.74574444
142Absent eyebrow (HP:0002223)1.73241056
143Hypochromic anemia (HP:0001931)1.72978020
144Stomach cancer (HP:0012126)1.72912946
145Abnormality of the labia minora (HP:0012880)1.72277496
146Advanced eruption of teeth (HP:0006288)1.71927376
147Hyperthyroidism (HP:0000836)1.71088294
148Disinhibition (HP:0000734)1.70975179
149Thyroid-stimulating hormone excess (HP:0002925)1.70658333
150Exotropia (HP:0000577)1.70487180
151Bronchomalacia (HP:0002780)1.69787497
152Abnormality of the ischium (HP:0003174)1.69567884
153Buphthalmos (HP:0000557)1.69545871
154Abnormality of macrophages (HP:0004311)1.69477175
155Chest pain (HP:0100749)1.69171672
156Genu recurvatum (HP:0002816)1.68804692
157Vascular tortuosity (HP:0004948)1.68798495
158Fair hair (HP:0002286)1.68789215
159Abnormality of oral frenula (HP:0000190)1.68728438
160Abnormality of the right ventricle (HP:0001707)1.68342830
161Papilledema (HP:0001085)1.67955792
162Natal tooth (HP:0000695)1.67730423
163Hypochromic microcytic anemia (HP:0004840)1.66392341
164Elevated erythrocyte sedimentation rate (HP:0003565)1.66050322
165Abnormality of the vasculature of the conjunctiva (HP:0008054)1.65583956
166Hypoplasia of the maxilla (HP:0000327)1.64712523
167Abolished electroretinogram (ERG) (HP:0000550)1.64545263
168Submucous cleft hard palate (HP:0000176)1.63981766
169Cervical subluxation (HP:0003308)1.63879897
170Atrophic scars (HP:0001075)1.62799643
171Aplasia/Hypoplasia of the sternum (HP:0006714)1.62733362
172Menorrhagia (HP:0000132)1.62518898
173Urethral obstruction (HP:0000796)1.62304457
174Curly hair (HP:0002212)1.61668719
175Proximal placement of thumb (HP:0009623)1.61596067
176Cerebellar dysplasia (HP:0007033)1.61158914
177Thrombophlebitis (HP:0004418)1.60956000
178Widely spaced teeth (HP:0000687)1.60787941
179Excessive salivation (HP:0003781)1.59930699
180Drooling (HP:0002307)1.59930699
181Dental malocclusion (HP:0000689)1.59809871
182Thick eyebrow (HP:0000574)1.59733946
183Abnormal auditory evoked potentials (HP:0006958)1.59608872
184Episodic fever (HP:0001954)1.59308520
185Aneurysm (HP:0002617)1.58587775
186Dislocated radial head (HP:0003083)1.58323398
187Cerebral aneurysm (HP:0004944)1.58308084
188Broad finger (HP:0001500)1.57133862
189Long eyelashes (HP:0000527)1.56362155
190Hypoplastic female external genitalia (HP:0012815)1.55949887
191Termporal pattern (HP:0011008)1.55243100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.72249237
2LATS13.82543579
3PBK3.05746510
4ERBB32.75506394
5PRKCH2.73218002
6NUAK12.40816175
7EPHA32.39542039
8FGFR32.16004556
9STK32.13300693
10TXK2.10167184
11FES2.09009956
12TAOK32.03352778
13AKT32.03253564
14PLK22.00259925
15MST41.95657783
16CAMKK21.89260406
17EIF2AK31.82891575
18TEC1.82822316
19EPHB21.80496531
20BMPR21.77586883
21CDK121.76885093
22FER1.74494644
23MAP3K21.73703692
24MARK11.72857473
25NTRK31.68858068
26SIK31.64615307
27FGFR21.62888622
28LATS21.58559550
29MAPK131.57724556
30FGFR11.57080593
31KSR11.55952705
32SCYL21.53595378
33CASK1.53009334
34SGK21.48542180
35DMPK1.47937320
36IRAK21.47506460
37RIPK41.47099027
38PDGFRA1.46901922
39MAP3K41.45627495
40SGK31.42796814
41PIK3CG1.40388504
42NEK91.39658264
43NLK1.39453584
44PLK31.39196622
45CSK1.36625634
46PIK3CA1.33841265
47CDK61.30724799
48YES11.29392399
49MAP4K21.28496878
50MAP3K61.27949210
51MINK11.24525023
52CAMK1D1.24319726
53MAP4K11.19055022
54RPS6KA41.18346156
55BCR1.17236429
56RIPK11.15778795
57TRIM281.13817329
58PTK21.11930540
59MAP3K121.08430270
60NEK11.07871223
61TRPM71.07695979
62CAMK1G1.06820012
63MAP3K141.02741776
64SYK1.01172196
65IKBKE1.00310828
66KIT1.00134684
67DDR20.98212669
68RET0.98025269
69PTK60.97495010
70EIF2AK10.94876896
71BLK0.94624063
72LCK0.94607654
73RAF10.94407673
74INSRR0.90505021
75FGR0.88971178
76STK240.86833001
77ERBB40.86727115
78JAK20.82848659
79CSF1R0.82716042
80LYN0.82624849
81PTK2B0.82215777
82WNK10.81625896
83TRIB30.81472461
84BRSK20.80493642
85MELK0.80325328
86MATK0.79592622
87SIK10.78001372
88HCK0.77674945
89LIMK10.77538922
90BTK0.71790517
91BMPR1B0.71576387
92STK38L0.70798650
93JAK10.70649954
94PAK30.69992696
95MAP3K10.67347900
96EPHB10.66639277
97ADRBK20.66438960
98PDGFRB0.66324181
99STK390.65310817
100MAP2K40.64813537
101ROCK10.64124617
102STK100.64073189
103MTOR0.63823819
104RPS6KA20.63108374
105MAP3K90.61403820
106OXSR10.61022136
107MAP3K50.60974072
108CHUK0.59969268
109PLK40.59384684
110TYK20.59272692
111TTN0.59087303
112GRK60.58565879
113IRAK10.58240774
114PRKCQ0.58062808
115MAP2K10.57384707
116ITK0.56829773
117RPS6KB10.55642715
118MAP3K100.52418325
119CDC70.52256476
120DAPK10.52136238
121ADRBK10.52116833
122ERBB20.51538885
123PINK10.50670911
124PNCK0.50654670
125SGK10.49442561
126EGFR0.47953080
127CDK90.47543414
128PRKCE0.46275416
129IGF1R0.46166179
130MAPK40.45378903
131IRAK40.44783097
132NTRK20.44466183
133PRKG10.44437342
134CCNB10.43322565
135ATM0.43014433
136IKBKB0.42805867
137ALK0.42090069
138WNK30.41787669
139STK110.41228702
140TESK10.41219823
141KSR20.41112987
142ABL10.40825042
143MAPK140.39423736
144SGK4940.38797323
145SGK2230.38797323
146MAP2K70.37763967
147CDC42BPA0.36689942
148MAPK80.35712664
149INSR0.35624723
150ACVR1B0.34099196
151TGFBR10.32946636
152NTRK10.32552232
153JAK30.30947537
154FYN0.29055665
155PRKCB0.28275645
156SRC0.28111250
157LMTK20.27409798
158PKN20.27061319
159AKT10.26783127

Predicted pathways (KEGG)

RankGene SetZ-score
1Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.48068663
2Allograft rejection_Homo sapiens_hsa053302.27066973
3Malaria_Homo sapiens_hsa051442.25881867
4Staphylococcus aureus infection_Homo sapiens_hsa051502.25097867
5Graft-versus-host disease_Homo sapiens_hsa053322.18627949
6Autoimmune thyroid disease_Homo sapiens_hsa053202.10779469
7Adherens junction_Homo sapiens_hsa045201.96052531
8Endometrial cancer_Homo sapiens_hsa052131.61113920
9Colorectal cancer_Homo sapiens_hsa052101.58830061
10mTOR signaling pathway_Homo sapiens_hsa041501.56473506
11Measles_Homo sapiens_hsa051621.48426763
12Rheumatoid arthritis_Homo sapiens_hsa053231.48295523
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45628495
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45244705
15Primary immunodeficiency_Homo sapiens_hsa053401.44595113
16Hematopoietic cell lineage_Homo sapiens_hsa046401.44446788
17Type II diabetes mellitus_Homo sapiens_hsa049301.43016365
18Proteoglycans in cancer_Homo sapiens_hsa052051.42031287
19Glioma_Homo sapiens_hsa052141.41979789
20Pancreatic cancer_Homo sapiens_hsa052121.41502561
21RNA polymerase_Homo sapiens_hsa030201.39254153
22TGF-beta signaling pathway_Homo sapiens_hsa043501.39067443
23MicroRNAs in cancer_Homo sapiens_hsa052061.34948671
24Melanoma_Homo sapiens_hsa052181.33850391
25B cell receptor signaling pathway_Homo sapiens_hsa046621.30625682
26Focal adhesion_Homo sapiens_hsa045101.30142315
27Hippo signaling pathway_Homo sapiens_hsa043901.28739697
28Asthma_Homo sapiens_hsa053101.24489656
29Long-term potentiation_Homo sapiens_hsa047201.24277342
30Prostate cancer_Homo sapiens_hsa052151.23448634
31Phototransduction_Homo sapiens_hsa047441.22303872
32Chemokine signaling pathway_Homo sapiens_hsa040621.20588642
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20516890
34Chronic myeloid leukemia_Homo sapiens_hsa052201.19658425
35Dorso-ventral axis formation_Homo sapiens_hsa043201.19316155
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.19253900
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.18294809
38T cell receptor signaling pathway_Homo sapiens_hsa046601.17059551
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16972414
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16398656
41Protein export_Homo sapiens_hsa030601.16213781
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14653813
43TNF signaling pathway_Homo sapiens_hsa046681.14503275
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11753739
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.10037942
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09306042
47Toxoplasmosis_Homo sapiens_hsa051451.09167043
48Dopaminergic synapse_Homo sapiens_hsa047281.07572958
49Regulation of autophagy_Homo sapiens_hsa041401.07501831
50Small cell lung cancer_Homo sapiens_hsa052221.06124060
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05651542
52Prolactin signaling pathway_Homo sapiens_hsa049171.05541691
53FoxO signaling pathway_Homo sapiens_hsa040681.05367402
54Estrogen signaling pathway_Homo sapiens_hsa049151.05343362
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.04847952
56Type I diabetes mellitus_Homo sapiens_hsa049401.04810226
57ErbB signaling pathway_Homo sapiens_hsa040121.04498767
58Amoebiasis_Homo sapiens_hsa051461.04160454
59African trypanosomiasis_Homo sapiens_hsa051431.04136084
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02323418
61Viral myocarditis_Homo sapiens_hsa054161.02320472
62Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01172030
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99818404
64Hepatitis B_Homo sapiens_hsa051610.99527036
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99303880
66Bladder cancer_Homo sapiens_hsa052190.99285979
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99073334
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98728910
69Renal cell carcinoma_Homo sapiens_hsa052110.96955744
70Cholinergic synapse_Homo sapiens_hsa047250.95363383
71Thyroid cancer_Homo sapiens_hsa052160.95226114
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94413871
73Leishmaniasis_Homo sapiens_hsa051400.94413551
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94166174
75Non-small cell lung cancer_Homo sapiens_hsa052230.92248076
76Axon guidance_Homo sapiens_hsa043600.92022660
77Rap1 signaling pathway_Homo sapiens_hsa040150.91370916
78Olfactory transduction_Homo sapiens_hsa047400.90576628
79ECM-receptor interaction_Homo sapiens_hsa045120.90272589
80Linoleic acid metabolism_Homo sapiens_hsa005910.89590073
81Circadian rhythm_Homo sapiens_hsa047100.89450881
82Glycerolipid metabolism_Homo sapiens_hsa005610.89180577
83Insulin secretion_Homo sapiens_hsa049110.88910412
84Wnt signaling pathway_Homo sapiens_hsa043100.88882205
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88176051
86Legionellosis_Homo sapiens_hsa051340.87980110
87Basal transcription factors_Homo sapiens_hsa030220.87071127
88Renin secretion_Homo sapiens_hsa049240.86661597
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86102668
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85455802
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84866871
92Insulin resistance_Homo sapiens_hsa049310.84358459
93Synaptic vesicle cycle_Homo sapiens_hsa047210.83914202
94Melanogenesis_Homo sapiens_hsa049160.82261513
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81326057
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81203667
97Viral carcinogenesis_Homo sapiens_hsa052030.81050944
98Oocyte meiosis_Homo sapiens_hsa041140.80960570
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80068058
100Choline metabolism in cancer_Homo sapiens_hsa052310.79444678
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79365092
102Pathways in cancer_Homo sapiens_hsa052000.78383955
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77263229
104MAPK signaling pathway_Homo sapiens_hsa040100.76589909
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76516899
106Insulin signaling pathway_Homo sapiens_hsa049100.75598287
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.75571485
108Amphetamine addiction_Homo sapiens_hsa050310.75542781
109Osteoclast differentiation_Homo sapiens_hsa043800.75511556
110Tuberculosis_Homo sapiens_hsa051520.75034293
111Salmonella infection_Homo sapiens_hsa051320.74930050
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74800508
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.73966572
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73658443
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73249538
116Phagosome_Homo sapiens_hsa041450.73243401
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.72534788
118Serotonergic synapse_Homo sapiens_hsa047260.72507915
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71867258
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71548571
121Dilated cardiomyopathy_Homo sapiens_hsa054140.71346897
122Glucagon signaling pathway_Homo sapiens_hsa049220.70961452
123Gap junction_Homo sapiens_hsa045400.70873809
124Platelet activation_Homo sapiens_hsa046110.70653022
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70347137
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70222050
127Herpes simplex infection_Homo sapiens_hsa051680.70208230
128Influenza A_Homo sapiens_hsa051640.70101488
129Oxytocin signaling pathway_Homo sapiens_hsa049210.70019059
130p53 signaling pathway_Homo sapiens_hsa041150.69750474
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69147794
132Long-term depression_Homo sapiens_hsa047300.69108271
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69022557
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68911916
135HIF-1 signaling pathway_Homo sapiens_hsa040660.67408296
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67095020
137Ether lipid metabolism_Homo sapiens_hsa005650.66519628
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66091758
139Basal cell carcinoma_Homo sapiens_hsa052170.65886679
140HTLV-I infection_Homo sapiens_hsa051660.65429076
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.64971854
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64331799
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64213239
144Circadian entrainment_Homo sapiens_hsa047130.63822183
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.63146416
146VEGF signaling pathway_Homo sapiens_hsa043700.62351327
147Endocytosis_Homo sapiens_hsa041440.61266239
148ABC transporters_Homo sapiens_hsa020100.60516581
149Pertussis_Homo sapiens_hsa051330.60423854
150Nitrogen metabolism_Homo sapiens_hsa009100.57444860
151Collecting duct acid secretion_Homo sapiens_hsa049660.57045886
152Arachidonic acid metabolism_Homo sapiens_hsa005900.56775004
153Phospholipase D signaling pathway_Homo sapiens_hsa040720.55069161
154Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54764429
155Hepatitis C_Homo sapiens_hsa051600.51989600
156Acute myeloid leukemia_Homo sapiens_hsa052210.51374920
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50515193
158Pancreatic secretion_Homo sapiens_hsa049720.47158502
159Maturity onset diabetes of the young_Homo sapiens_hsa049500.45711660
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43412563
161Inositol phosphate metabolism_Homo sapiens_hsa005620.40040853

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