SHQ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et al., 2009 [PubMed 19383767]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)5.71571751
2polyketide metabolic process (GO:0030638)5.71571751
3doxorubicin metabolic process (GO:0044598)5.71571751
4regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.71034243
5nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.63597336
6exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62454628
7DNA replication checkpoint (GO:0000076)3.61419739
8telomere maintenance via semi-conservative replication (GO:0032201)3.60620971
9maturation of 5.8S rRNA (GO:0000460)3.59225297
10DNA replication initiation (GO:0006270)3.58324965
11L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.48372360
12regulation of mitotic spindle checkpoint (GO:1903504)3.45626497
13regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.45626497
14kinetochore assembly (GO:0051382)3.42629279
15DNA strand elongation involved in DNA replication (GO:0006271)3.41758919
16DNA strand elongation (GO:0022616)3.36544804
17ribosomal small subunit assembly (GO:0000028)3.36095074
18synapsis (GO:0007129)3.30554808
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.29671592
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.29671592
21aminoglycoside antibiotic metabolic process (GO:0030647)3.29031404
22protein deneddylation (GO:0000338)3.28983130
23piRNA metabolic process (GO:0034587)3.28909056
24telomere maintenance via recombination (GO:0000722)3.28714316
25kinetochore organization (GO:0051383)3.28460476
26cullin deneddylation (GO:0010388)3.27120439
27regulation of centriole replication (GO:0046599)3.25432794
28regulation of meiosis I (GO:0060631)3.24203822
29CENP-A containing nucleosome assembly (GO:0034080)3.23808582
30DNA deamination (GO:0045006)3.23051730
31meiotic chromosome segregation (GO:0045132)3.22931764
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.22005862
33ribosomal large subunit biogenesis (GO:0042273)3.20404223
34respiratory chain complex IV assembly (GO:0008535)3.19944059
35DNA catabolic process, exonucleolytic (GO:0000738)3.19024610
36regulation of helicase activity (GO:0051095)3.17064672
37ribosome biogenesis (GO:0042254)3.16906650
38chromatin remodeling at centromere (GO:0031055)3.16064983
39maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.15683538
40recombinational repair (GO:0000725)3.13351965
41double-strand break repair via homologous recombination (GO:0000724)3.12512812
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.11469774
43somatic diversification of immunoglobulins (GO:0016445)3.11226409
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09222071
45tRNA methylation (GO:0030488)3.07117255
46intra-S DNA damage checkpoint (GO:0031573)3.06375078
47somatic diversification of immune receptors (GO:0002200)3.04612323
48maturation of SSU-rRNA (GO:0030490)3.03874368
49mismatch repair (GO:0006298)3.03747992
50telomere maintenance via telomere lengthening (GO:0010833)3.02676241
51regulation of nuclear cell cycle DNA replication (GO:0033262)3.00966857
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96450688
53mitotic recombination (GO:0006312)2.95862956
54histone H2A acetylation (GO:0043968)2.94256706
55postreplication repair (GO:0006301)2.93786500
56regulation of mitochondrial translation (GO:0070129)2.93200243
57somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.93074208
58somatic cell DNA recombination (GO:0016444)2.93074208
59negative regulation of DNA-dependent DNA replication (GO:2000104)2.92323570
60L-methionine salvage (GO:0071267)2.91301525
61L-methionine biosynthetic process (GO:0071265)2.91301525
62amino acid salvage (GO:0043102)2.91301525
63tRNA processing (GO:0008033)2.90465231
64positive regulation of DNA-dependent DNA replication (GO:2000105)2.90280187
65IMP biosynthetic process (GO:0006188)2.88620556
66peptidyl-histidine modification (GO:0018202)2.88298201
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87434330
68response to X-ray (GO:0010165)2.85889946
69negative regulation of meiosis (GO:0045835)2.85743575
70resolution of meiotic recombination intermediates (GO:0000712)2.85726033
71replication fork processing (GO:0031297)2.85201369
72rRNA catabolic process (GO:0016075)2.84516743
73transcription elongation from RNA polymerase I promoter (GO:0006362)2.83936310
74ribonucleoprotein complex biogenesis (GO:0022613)2.83806643
75termination of RNA polymerase I transcription (GO:0006363)2.83295437
76water-soluble vitamin biosynthetic process (GO:0042364)2.82037939
77mitochondrial RNA metabolic process (GO:0000959)2.81681724
78pseudouridine synthesis (GO:0001522)2.80873990
79tRNA metabolic process (GO:0006399)2.80826314
80mitotic metaphase plate congression (GO:0007080)2.80697186
81deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80366744
82DNA recombination (GO:0006310)2.80341134
83DNA damage response, detection of DNA damage (GO:0042769)2.78734760
84nuclear pore organization (GO:0006999)2.77196929
85rRNA modification (GO:0000154)2.74929887
86DNA replication-independent nucleosome assembly (GO:0006336)2.74650202
87DNA replication-independent nucleosome organization (GO:0034724)2.74650202
88negative regulation of ligase activity (GO:0051352)2.73045423
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73045423
90nucleotide-excision repair, DNA gap filling (GO:0006297)2.72820264
91ubiquinone metabolic process (GO:0006743)2.71959160
92DNA double-strand break processing (GO:0000729)2.71832358
93folic acid-containing compound biosynthetic process (GO:0009396)2.71208808
94regulation of double-strand break repair via homologous recombination (GO:0010569)2.70661022
95ubiquinone biosynthetic process (GO:0006744)2.70319782
96methionine biosynthetic process (GO:0009086)2.70135289
97cytochrome complex assembly (GO:0017004)2.69982046
98rRNA processing (GO:0006364)2.69865671
99histone mRNA metabolic process (GO:0008334)2.68353985
100attachment of spindle microtubules to kinetochore (GO:0008608)2.68166946
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66298893
102telomere maintenance (GO:0000723)2.64253234
103energy homeostasis (GO:0097009)2.64133512
104telomere organization (GO:0032200)2.62570736
105rRNA metabolic process (GO:0016072)2.61325277
106protein K6-linked ubiquitination (GO:0085020)2.60789364
107DNA integration (GO:0015074)2.60614726
108reciprocal DNA recombination (GO:0035825)2.59750934
109reciprocal meiotic recombination (GO:0007131)2.59750934
110metaphase plate congression (GO:0051310)2.59474741
111somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.58527289
112somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.58527289
113isotype switching (GO:0045190)2.58527289
114centriole assembly (GO:0098534)2.57815034
115transcription from RNA polymerase I promoter (GO:0006360)2.57502596
116DNA unwinding involved in DNA replication (GO:0006268)2.55757641
117rRNA methylation (GO:0031167)2.55491018
118somatic hypermutation of immunoglobulin genes (GO:0016446)2.54782518
119somatic diversification of immune receptors via somatic mutation (GO:0002566)2.54782518
120regulation of spindle checkpoint (GO:0090231)2.53928672
121regulation of DNA endoreduplication (GO:0032875)2.53680631
122nucleobase biosynthetic process (GO:0046112)2.52717054
123DNA strand renaturation (GO:0000733)2.52545260
124detection of molecule of bacterial origin (GO:0032490)2.52411818
125pore complex assembly (GO:0046931)2.49739596
126somatic recombination of immunoglobulin gene segments (GO:0016447)2.47589637
127DNA synthesis involved in DNA repair (GO:0000731)2.46608381
128histone exchange (GO:0043486)2.45190861
129transcription initiation from RNA polymerase I promoter (GO:0006361)2.44886197
130RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44368714
1317-methylguanosine mRNA capping (GO:0006370)2.44105189
132RNA capping (GO:0036260)2.44076868
1337-methylguanosine RNA capping (GO:0009452)2.44076868
134replicative senescence (GO:0090399)2.43625028
135proteasome assembly (GO:0043248)2.43024443
136nuclear pore complex assembly (GO:0051292)2.42958299
137DNA replication-dependent nucleosome organization (GO:0034723)2.42753095
138DNA replication-dependent nucleosome assembly (GO:0006335)2.42753095
139transcription-coupled nucleotide-excision repair (GO:0006283)2.42621572
140establishment of integrated proviral latency (GO:0075713)2.42400032
141spliceosomal snRNP assembly (GO:0000387)2.41068547
142negative regulation of mast cell activation (GO:0033004)2.39973701
143ribosome assembly (GO:0042255)2.39820036
144tRNA modification (GO:0006400)2.39782971
145regulation of DNA-dependent DNA replication (GO:0090329)2.37570897
146transcription elongation from RNA polymerase III promoter (GO:0006385)2.37487497
147termination of RNA polymerase III transcription (GO:0006386)2.37487497
148ncRNA processing (GO:0034470)2.36363455
149DNA-dependent DNA replication (GO:0006261)2.35076248
150purine nucleobase biosynthetic process (GO:0009113)2.34976210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.20862338
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.58055042
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44574624
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18397446
5TP63_19390658_ChIP-ChIP_HaCaT_Human2.98435546
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94320394
7ZNF274_21170338_ChIP-Seq_K562_Hela2.72063826
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.71216716
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71097913
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48989061
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48866761
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.46942116
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45868220
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41882034
15* NOTCH1_21737748_ChIP-Seq_TLL_Human2.36539432
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34390242
17VDR_22108803_ChIP-Seq_LS180_Human2.33308753
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.30322378
19* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24823318
20* GABP_17652178_ChIP-ChIP_JURKAT_Human2.17198444
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.15264909
22VDR_23849224_ChIP-Seq_CD4+_Human2.13274109
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11277995
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.10380112
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06559368
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05997054
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05058502
28FOXP3_21729870_ChIP-Seq_TREG_Human1.97984072
29SCL_19346495_ChIP-Seq_HPC-7_Human1.97142184
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96680274
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95607259
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95514116
33ELK1_19687146_ChIP-ChIP_HELA_Human1.84299214
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.83134289
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82523277
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.81627100
37* IGF1R_20145208_ChIP-Seq_DFB_Human1.80043896
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78012713
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77830612
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77818897
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76463454
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74719273
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69369827
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67565746
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62732159
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61517589
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56641314
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55128960
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.51343143
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.50645253
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48864500
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.48314102
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46998279
54TTF2_22483619_ChIP-Seq_HELA_Human1.45429774
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45113201
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.44517124
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43236914
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42225674
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39077796
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.36389220
61* GABP_19822575_ChIP-Seq_HepG2_Human1.33983774
62XRN2_22483619_ChIP-Seq_HELA_Human1.32277564
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31977248
64* SPI1_23547873_ChIP-Seq_NB4_Human1.31839201
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31196148
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.29303376
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27720626
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27448270
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27313558
70P300_19829295_ChIP-Seq_ESCs_Human1.25999454
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24302659
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23846010
73TAF15_26573619_Chip-Seq_HEK293_Human1.23539783
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21099764
75EWS_26573619_Chip-Seq_HEK293_Human1.20951236
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20574924
77* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19668784
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19134894
79* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18569064
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17879914
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17304931
82DCP1A_22483619_ChIP-Seq_HELA_Human1.16405020
83AR_21909140_ChIP-Seq_LNCAP_Human1.16278141
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16182457
85ER_23166858_ChIP-Seq_MCF-7_Human1.13913783
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11454249
87GBX2_23144817_ChIP-Seq_PC3_Human1.10089081
88IRF1_19129219_ChIP-ChIP_H3396_Human1.09982184
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09618075
90CIITA_25753668_ChIP-Seq_RAJI_Human1.09512577
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08935172
92MYC_18940864_ChIP-ChIP_HL60_Human1.08451525
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06570357
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06570357
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06570357
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04358667
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.03397171
98* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03113791
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02129063
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01801938
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.00754990
102* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99596427
103TP53_22573176_ChIP-Seq_HFKS_Human0.99349701
104SOX2_16153702_ChIP-ChIP_HESCs_Human0.98771564
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97557379
106CBP_20019798_ChIP-Seq_JUKART_Human0.97417785
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97417785
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96704768
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96178427
110FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96168990
111EZH2_27294783_Chip-Seq_NPCs_Mouse0.95002730
112KDM5A_27292631_Chip-Seq_BREAST_Human0.93602674
113STAT3_18555785_Chip-Seq_ESCs_Mouse0.93192458
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91371643
115FOXA1_25329375_ChIP-Seq_VCAP_Human0.88494987
116FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88494987
117SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88241705
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87894206
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87084410
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85335000
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85190582
122RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83247474
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82821336
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82106035
125FUS_26573619_Chip-Seq_HEK293_Human0.81896504
126E2F1_18555785_Chip-Seq_ESCs_Mouse0.81880033
127* IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81616069
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81135046
129* NANOG_19829295_ChIP-Seq_ESCs_Human0.80872847
130* SOX2_19829295_ChIP-Seq_ESCs_Human0.80872847
131SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80846717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.01591116
2MP0002396_abnormal_hematopoietic_system3.49095060
3MP0008058_abnormal_DNA_repair3.42527118
4MP0010094_abnormal_chromosome_stability3.35530550
5MP0006292_abnormal_olfactory_placode3.33729867
6MP0000566_synostosis3.20135306
7MP0003111_abnormal_nucleus_morphology3.13591174
8MP0008057_abnormal_DNA_replication2.86864607
9MP0005377_hearing/vestibular/ear_phenot2.71278807
10MP0003878_abnormal_ear_physiology2.71278807
11MP0003806_abnormal_nucleotide_metabolis2.62643643
12MP0003077_abnormal_cell_cycle2.57043970
13MP0006072_abnormal_retinal_apoptosis2.49145369
14MP0002277_abnormal_respiratory_mucosa2.26700858
15MP0005257_abnormal_intraocular_pressure2.24381419
16MP0001986_abnormal_taste_sensitivity2.13925359
17MP0004957_abnormal_blastocyst_morpholog2.07331890
18MP0001188_hyperpigmentation2.04422144
19MP0003646_muscle_fatigue1.98454391
20MP0000490_abnormal_crypts_of1.96754138
21MP0005075_abnormal_melanosome_morpholog1.96075291
22MP0008007_abnormal_cellular_replicative1.91890556
23MP0009697_abnormal_copulation1.91127995
24MP0002160_abnormal_reproductive_system1.87948489
25MP0006035_abnormal_mitochondrial_morpho1.86289115
26MP0008877_abnormal_DNA_methylation1.83503120
27MP0005174_abnormal_tail_pigmentation1.82896872
28MP0002938_white_spotting1.80179552
29MP0000015_abnormal_ear_pigmentation1.67417524
30MP0003941_abnormal_skin_development1.64684905
31MP0002163_abnormal_gland_morphology1.63827639
32MP0001835_abnormal_antigen_presentation1.56856207
33MP0005253_abnormal_eye_physiology1.56557139
34MP0003786_premature_aging1.56424903
35MP0006036_abnormal_mitochondrial_physio1.55156463
36MP0008932_abnormal_embryonic_tissue1.53693960
37MP0000569_abnormal_digit_pigmentation1.52314383
38MP0003136_yellow_coat_color1.51446900
39MP0003890_abnormal_embryonic-extraembry1.49081444
40MP0002837_dystrophic_cardiac_calcinosis1.47598524
41MP0002132_abnormal_respiratory_system1.44940669
42MP0002095_abnormal_skin_pigmentation1.44804515
43MP0001929_abnormal_gametogenesis1.43357783
44MP0003567_abnormal_fetal_cardiomyocyte1.42004305
45MP0000427_abnormal_hair_cycle1.40980531
46MP0008789_abnormal_olfactory_epithelium1.36897095
47MP0002102_abnormal_ear_morphology1.34698157
48MP0004808_abnormal_hematopoietic_stem1.34348999
49MP0005671_abnormal_response_to1.28940488
50MP0003195_calcinosis1.25525330
51MP0003763_abnormal_thymus_physiology1.24749097
52MP0002210_abnormal_sex_determination1.23551314
53MP0005551_abnormal_eye_electrophysiolog1.23096326
54MP0001529_abnormal_vocalization1.20730017
55MP0003718_maternal_effect1.18043893
56MP0002075_abnormal_coat/hair_pigmentati1.17867987
57MP0001293_anophthalmia1.16830307
58MP0003186_abnormal_redox_activity1.15465172
59MP0005084_abnormal_gallbladder_morpholo1.14453926
60MP0000358_abnormal_cell_content/1.14430523
61MP0002751_abnormal_autonomic_nervous1.13845432
62MP0001661_extended_life_span1.13467566
63MP0004147_increased_porphyrin_level1.12772192
64MP0002148_abnormal_hypersensitivity_rea1.12627976
65MP0000383_abnormal_hair_follicle1.11871777
66MP0002398_abnormal_bone_marrow1.10876906
67MP0008004_abnormal_stomach_pH1.10515281
68MP0001730_embryonic_growth_arrest1.09122475
69MP0005171_absent_coat_pigmentation1.08988466
70MP0001800_abnormal_humoral_immune1.05988862
71MP0001186_pigmentation_phenotype1.05688277
72MP0002452_abnormal_antigen_presenting1.05171194
73MP0000647_abnormal_sebaceous_gland1.03722862
74MP0000371_diluted_coat_color1.03282047
75MP0000313_abnormal_cell_death1.02609325
76MP0003698_abnormal_male_reproductive1.02357673
77MP0008995_early_reproductive_senescence1.01419612
78MP0000350_abnormal_cell_proliferation1.01031354
79MP0005645_abnormal_hypothalamus_physiol1.00342125
80MP0008872_abnormal_physiological_respon0.99914899
81MP0004215_abnormal_myocardial_fiber0.99754424
82MP0001119_abnormal_female_reproductive0.99747808
83MP0005379_endocrine/exocrine_gland_phen0.99657941
84MP0002723_abnormal_immune_serum0.99640502
85MP0000372_irregular_coat_pigmentation0.99453016
86MP0009785_altered_susceptibility_to0.99136144
87MP0001346_abnormal_lacrimal_gland0.98338267
88MP0002420_abnormal_adaptive_immunity0.97444871
89MP0001819_abnormal_immune_cell0.97139521
90MP0002419_abnormal_innate_immunity0.97070614
91MP0001984_abnormal_olfaction0.96237272
92MP0004381_abnormal_hair_follicle0.96203703
93MP0005395_other_phenotype0.94958314
94MP0001764_abnormal_homeostasis0.94953453
95MP0001697_abnormal_embryo_size0.92739024
96MP0002084_abnormal_developmental_patter0.92583711
97MP0000049_abnormal_middle_ear0.91624582
98MP0000703_abnormal_thymus_morphology0.89642181
99MP0000716_abnormal_immune_system0.89604361
100MP0001145_abnormal_male_reproductive0.89243658
101MP0002722_abnormal_immune_system0.89051126
102MP0001545_abnormal_hematopoietic_system0.88892622
103MP0005397_hematopoietic_system_phenotyp0.88892622
104MP0000689_abnormal_spleen_morphology0.88785810
105MP0001919_abnormal_reproductive_system0.88468427
106MP0002429_abnormal_blood_cell0.87836398
107MP0005025_abnormal_response_to0.86660221
108MP0005408_hypopigmentation0.86513786
109MP0003943_abnormal_hepatobiliary_system0.86085056
110MP0009333_abnormal_splenocyte_physiolog0.85024272
111MP0010678_abnormal_skin_adnexa0.84575245
112MP0002019_abnormal_tumor_incidence0.83399185
113MP0003121_genomic_imprinting0.83372311
114MP0005187_abnormal_penis_morphology0.82525968
115MP0005499_abnormal_olfactory_system0.82216864
116MP0005394_taste/olfaction_phenotype0.82216864
117MP0005367_renal/urinary_system_phenotyp0.81646953
118MP0000516_abnormal_urinary_system0.81646953
119MP0005464_abnormal_platelet_physiology0.80382342
120MP0000653_abnormal_sex_gland0.79610535
121MP0002736_abnormal_nociception_after0.79544274
122MP0004133_heterotaxia0.79410679
123MP0005000_abnormal_immune_tolerance0.79064376
124MP0004782_abnormal_surfactant_physiolog0.78834091
125MP0005646_abnormal_pituitary_gland0.78549154
126MP0000678_abnormal_parathyroid_gland0.78488689
127MP0005391_vision/eye_phenotype0.76968813
128MP0005389_reproductive_system_phenotype0.76925321
129MP0001790_abnormal_immune_system0.76536937
130MP0005387_immune_system_phenotype0.76536937
131MP0004145_abnormal_muscle_electrophysio0.76252888
132MP0010307_abnormal_tumor_latency0.76097025
133MP0008875_abnormal_xenobiotic_pharmacok0.75722358
134MP0003937_abnormal_limbs/digits/tail_de0.75570225
135MP0002638_abnormal_pupillary_reflex0.75338124
136MP0001853_heart_inflammation0.75072907
137MP0001324_abnormal_eye_pigmentation0.74547859
138MP0004742_abnormal_vestibular_system0.74160676
139MP0008260_abnormal_autophagy0.73244883
140MP0003252_abnormal_bile_duct0.72502854
141MP0003436_decreased_susceptibility_to0.71840274
142MP0006276_abnormal_autonomic_nervous0.71230955
143MP0003787_abnormal_imprinting0.71096749
144MP0000858_altered_metastatic_potential0.70679873
145MP0003315_abnormal_perineum_morphology0.69955146
146MP0005380_embryogenesis_phenotype0.69854457
147MP0001672_abnormal_embryogenesis/_devel0.69854457
148MP0002085_abnormal_embryonic_tissue0.69290805
149MP0002254_reproductive_system_inflammat0.69258462
150MP0002233_abnormal_nose_morphology0.69079459
151MP0005410_abnormal_fertilization0.65479200
152MP0003936_abnormal_reproductive_system0.65110189

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.93517979
2Chromsome breakage (HP:0040012)5.78673461
3Duplicated collecting system (HP:0000081)3.84122719
4Abnormality of the renal collecting system (HP:0004742)3.66182184
5Prostate neoplasm (HP:0100787)3.50966146
6Abnormality of the preputium (HP:0100587)3.49544792
7Abnormality of chromosome stability (HP:0003220)3.48076935
8Reticulocytopenia (HP:0001896)3.35864898
9Birth length less than 3rd percentile (HP:0003561)3.35378434
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.33552926
11Colon cancer (HP:0003003)3.28553328
12Ectopic kidney (HP:0000086)3.27560322
13Meckel diverticulum (HP:0002245)3.17773284
14Abnormality of the ileum (HP:0001549)3.04059200
15Abnormality of DNA repair (HP:0003254)2.84569156
16Increased CSF lactate (HP:0002490)2.80779432
17Clubbing of toes (HP:0100760)2.79843712
18Acute necrotizing encephalopathy (HP:0006965)2.76603155
19Abnormality of midbrain morphology (HP:0002418)2.76185314
20Molar tooth sign on MRI (HP:0002419)2.76185314
21Abnormality of the labia minora (HP:0012880)2.74695928
22Lipid accumulation in hepatocytes (HP:0006561)2.68869246
23Methylmalonic acidemia (HP:0002912)2.66186809
24Acute encephalopathy (HP:0006846)2.62398146
25Abnormal protein glycosylation (HP:0012346)2.61311621
26Abnormal glycosylation (HP:0012345)2.61311621
27Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.61311621
28Abnormal protein N-linked glycosylation (HP:0012347)2.61311621
29Patchy hypopigmentation of hair (HP:0011365)2.53691066
30Aplastic anemia (HP:0001915)2.53511660
31Nephronophthisis (HP:0000090)2.52348477
32Bone marrow hypocellularity (HP:0005528)2.50240947
33Myelodysplasia (HP:0002863)2.50082551
34Type I transferrin isoform profile (HP:0003642)2.45132441
35Mitochondrial inheritance (HP:0001427)2.44726253
36Abnormality of the prostate (HP:0008775)2.43997452
37Increased serum lactate (HP:0002151)2.42969001
38Microvesicular hepatic steatosis (HP:0001414)2.42798551
39True hermaphroditism (HP:0010459)2.42762990
40Increased hepatocellular lipid droplets (HP:0006565)2.42177454
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41220484
42Abnormality of alanine metabolism (HP:0010916)2.41220484
43Hyperalaninemia (HP:0003348)2.41220484
44Premature graying of hair (HP:0002216)2.41205956
45Unilateral renal agenesis (HP:0000122)2.41012556
46Agnosia (HP:0010524)2.40325637
47Hypergonadotropic hypogonadism (HP:0000815)2.39587447
48Abnormal mitochondria in muscle tissue (HP:0008316)2.34428053
49Septo-optic dysplasia (HP:0100842)2.34422836
50Progressive macrocephaly (HP:0004481)2.34049207
51Small intestinal stenosis (HP:0012848)2.29901949
52Duodenal stenosis (HP:0100867)2.29901949
53Pancreatic fibrosis (HP:0100732)2.28576490
54Medulloblastoma (HP:0002885)2.28401357
55Hepatocellular necrosis (HP:0001404)2.27562412
56White forelock (HP:0002211)2.26367891
57Parakeratosis (HP:0001036)2.25737837
58Cheilitis (HP:0100825)2.22752088
59Hepatic necrosis (HP:0002605)2.21488368
60Reduced antithrombin III activity (HP:0001976)2.21148249
61Abnormal trabecular bone morphology (HP:0100671)2.20938908
62Supernumerary spleens (HP:0009799)2.20672743
63Type II lissencephaly (HP:0007260)2.18986564
64Ependymoma (HP:0002888)2.17832271
65Methylmalonic aciduria (HP:0012120)2.17772338
66Renal cortical cysts (HP:0000803)2.17726222
67Congenital stationary night blindness (HP:0007642)2.17169308
68Sloping forehead (HP:0000340)2.17137523
69Abnormal biliary tract physiology (HP:0012439)2.15394771
70Bile duct proliferation (HP:0001408)2.15394771
71Triphalangeal thumb (HP:0001199)2.15331965
72Abnormality of the renal cortex (HP:0011035)2.15082141
73Glioma (HP:0009733)2.14004958
74Hypoplasia of the pons (HP:0012110)2.13856305
75Recurrent pneumonia (HP:0006532)2.12028796
76Patellar aplasia (HP:0006443)2.08771296
77Chronic hepatic failure (HP:0100626)2.07815770
78Sclerocornea (HP:0000647)2.07441405
79Abnormality of the renal medulla (HP:0100957)2.06219177
80Abnormality of the carotid arteries (HP:0005344)2.06211411
81Absent thumb (HP:0009777)2.06081692
82Neoplasm of the adrenal cortex (HP:0100641)2.05609953
83Retinal dysplasia (HP:0007973)2.05347115
84Absent radius (HP:0003974)2.04912607
85Abnormality of the pons (HP:0007361)2.04561634
86Abnormality of pyrimidine metabolism (HP:0004353)2.03705957
87Duplication of thumb phalanx (HP:0009942)2.03680480
88Cerebral edema (HP:0002181)2.03531332
89Pancreatic cysts (HP:0001737)2.02241540
90Neoplasm of the adrenal gland (HP:0100631)2.02003748
91Abolished electroretinogram (ERG) (HP:0000550)2.01594739
92Lactic acidosis (HP:0003128)2.01399125
93Hyperglycinemia (HP:0002154)2.01396407
94Prolonged bleeding time (HP:0003010)1.99022211
95Abnormal spermatogenesis (HP:0008669)1.94695954
96Rough bone trabeculation (HP:0100670)1.93031860
97Asplenia (HP:0001746)1.92276156
98Abnormality of the duodenum (HP:0002246)1.91025390
99Abnormality of serum amino acid levels (HP:0003112)1.90684366
100Type 2 muscle fiber atrophy (HP:0003554)1.90527677
1013-Methylglutaconic aciduria (HP:0003535)1.89353339
102Absent forearm bone (HP:0003953)1.88160693
103Aplasia involving forearm bones (HP:0009822)1.88160693
104Oligohydramnios (HP:0001562)1.88129488
105Abnormality of the intervertebral disk (HP:0005108)1.87540012
106IgG deficiency (HP:0004315)1.87337092
107Abnormality of the columella (HP:0009929)1.86859766
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86510597
109Medial flaring of the eyebrow (HP:0010747)1.85598487
110Recurrent abscess formation (HP:0002722)1.85508189
111Aplasia/Hypoplasia of the patella (HP:0006498)1.85461108
112Ectropion (HP:0000656)1.84584521
113Tracheoesophageal fistula (HP:0002575)1.84353439
11411 pairs of ribs (HP:0000878)1.84289615
115Aplasia/Hypoplasia of the tongue (HP:0010295)1.84141461
116Progressive inability to walk (HP:0002505)1.84131797
117Postaxial foot polydactyly (HP:0001830)1.83002973
118Male pseudohermaphroditism (HP:0000037)1.82626188
119Osteomalacia (HP:0002749)1.81605699
120Aplasia cutis congenita (HP:0001057)1.80942350
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.80469311
122Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80298821
123Nephroblastoma (Wilms tumor) (HP:0002667)1.79204484
124Abnormal lung lobation (HP:0002101)1.79035376
125Breast hypoplasia (HP:0003187)1.79034044
126Albinism (HP:0001022)1.79027340
127IgM deficiency (HP:0002850)1.78778599
128Rhabdomyosarcoma (HP:0002859)1.78405243
129Lymphoma (HP:0002665)1.77015280
130Ureteral duplication (HP:0000073)1.74638716
131Abnormality of methionine metabolism (HP:0010901)1.74140446
132Pancytopenia (HP:0001876)1.73583212
133Carpal bone hypoplasia (HP:0001498)1.73234335
134Small hand (HP:0200055)1.73109243
135Impulsivity (HP:0100710)1.72746478
136Mediastinal lymphadenopathy (HP:0100721)1.72627961
137Muscle fiber atrophy (HP:0100295)1.72427376
138Anencephaly (HP:0002323)1.72291015
139Preaxial hand polydactyly (HP:0001177)1.72254880
140Short tibia (HP:0005736)1.71875022
141Embryonal renal neoplasm (HP:0011794)1.71523508
142Pallor (HP:0000980)1.71267974
143Aplasia/Hypoplasia of the spleen (HP:0010451)1.70974681
144Horseshoe kidney (HP:0000085)1.70691474
145Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70483172
146Astrocytoma (HP:0009592)1.69377604
147Abnormality of the astrocytes (HP:0100707)1.69377604
148Abnormality of dental color (HP:0011073)1.67849729
149Short thumb (HP:0009778)1.67688096
150Abnormality of male internal genitalia (HP:0000022)1.67074152
151Adrenal hypoplasia (HP:0000835)1.66437579
152Cleft eyelid (HP:0000625)1.66224693
153Thrombocytosis (HP:0001894)1.66030444
154Abnormal number of erythroid precursors (HP:0012131)1.65230172
155Recurrent lower respiratory tract infections (HP:0002783)1.63336080
156Leukopenia (HP:0001882)1.61143134
157Pendular nystagmus (HP:0012043)1.60885402
158Abnormality of incisor morphology (HP:0011063)1.59798190
159Abnormality of the incisor (HP:0000676)1.59352480
160Amaurosis fugax (HP:0100576)1.59099453
161Aseptic necrosis (HP:0010885)1.58865330
162Hypoplastic iliac wings (HP:0002866)1.58863822
163Occipital encephalocele (HP:0002085)1.58815951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK83.59904241
2SIK33.10088211
3VRK23.00598489
4CDC72.97014497
5FRK2.90386525
6MAP4K22.83732712
7TRIM282.69625575
8SRPK12.65726969
9ZAK2.60797153
10MST42.40503883
11PLK42.28481460
12WEE12.26555684
13STK162.26181286
14TAF12.10912801
15VRK12.10658782
16BUB12.05189034
17TXK1.90021676
18MKNK21.89141128
19ACVR1B1.88476648
20WNK31.86458050
21CDK71.80690404
22ATR1.78069590
23IRAK31.73441525
24MKNK11.72467107
25CDK121.71059756
26EIF2AK11.63958662
27IRAK41.59970739
28TEC1.58843897
29NEK11.56331745
30TLK11.56174950
31PINK11.55151197
32STK38L1.51961096
33TTK1.50257630
34EIF2AK21.49329568
35STK31.46720023
36ADRBK21.41995016
37CSNK1G11.36645608
38CSNK1G31.36578566
39CHEK21.36328077
40EPHA21.35470152
41MARK31.34251848
42BCR1.31752853
43BMPR1B1.28432875
44BCKDK1.27843302
45NEK21.27812485
46CASK1.24475970
47CSNK1A1L1.23323849
48RPS6KA41.22852100
49MAP3K141.22745984
50NUAK11.21452992
51TNIK1.16436574
52PLK11.15183394
53CSNK1G21.14948487
54BRSK21.12955791
55INSRR1.12483975
56STK41.12226241
57DYRK31.10998211
58PLK21.10156116
59IKBKB1.05260531
60BLK1.04273813
61YES11.00615973
62SIK21.00365410
63CDK40.99657050
64OXSR10.98647228
65MAP4K10.97550764
66KIT0.97408053
67MAPKAPK50.97395773
68AURKB0.96703179
69PLK30.95889509
70TSSK60.95593051
71RPS6KA50.94062490
72BTK0.92875011
73TGFBR10.92837519
74PIM10.92353859
75EIF2AK30.92279218
76NLK0.91393176
77ERBB30.90755531
78TNK20.89076356
79PIM20.88248157
80PBK0.87744212
81BRD40.86920046
82DYRK20.86294655
83JAK30.85808131
84ATM0.85778469
85CDK30.79222492
86CHEK10.78831914
87TGFBR20.75920693
88NME20.74531073
89RPS6KB20.74290442
90CLK10.74237989
91CCNB10.74051298
92BMPR20.72658365
93NEK60.69689224
94STK390.68333939
95MAPK130.67822620
96PNCK0.67292338
97GRK10.64487221
98CHUK0.62004602
99GRK70.61349362
100DAPK10.60006919
101PDK20.59959817
102MAP3K40.59332385
103CSNK2A10.59113524
104CSF1R0.58704160
105MUSK0.58379933
106BRSK10.58074967
107MAP2K70.57555316
108PASK0.57513054
109LYN0.56765544
110NME10.56688302
111FLT30.55187910
112TAOK30.54699222
113CDK190.54516764
114CDK20.54419740
115PAK40.54259595
116PRPF4B0.52970145
117TIE10.51965969
118STK100.50683194
119AKT30.50504485
120CSNK2A20.49114118
121STK240.47408255
122MAPKAPK30.44177427
123WNK40.41150369
124CDK90.40580202
125IRAK10.40478930
126MELK0.39825580
127RPS6KA60.38989481
128KDR0.38779362
129CSNK1D0.36244100
130CDK10.36169390
131LATS10.34959972
132MAPKAPK20.33044934
133AURKA0.32899105
134MAPK110.32885009
135PRKCI0.31392014
136ADRBK10.31048469
137PAK30.26084351
138PRKCQ0.24523393
139CSNK1A10.24129654
140PRKCE0.23263350

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.01872554
2Mismatch repair_Homo sapiens_hsa034303.61343703
3Homologous recombination_Homo sapiens_hsa034403.57875927
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12532722
5Fanconi anemia pathway_Homo sapiens_hsa034602.97682032
6Basal transcription factors_Homo sapiens_hsa030222.92612234
7Base excision repair_Homo sapiens_hsa034102.70242720
8RNA polymerase_Homo sapiens_hsa030202.59681054
9Spliceosome_Homo sapiens_hsa030402.59436317
10Nucleotide excision repair_Homo sapiens_hsa034202.41223226
11Non-homologous end-joining_Homo sapiens_hsa034502.38537828
12Cell cycle_Homo sapiens_hsa041102.19301912
13Ribosome_Homo sapiens_hsa030102.16594362
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13803208
15Propanoate metabolism_Homo sapiens_hsa006402.10364718
16Pyrimidine metabolism_Homo sapiens_hsa002402.09496697
17One carbon pool by folate_Homo sapiens_hsa006702.07719725
18RNA transport_Homo sapiens_hsa030132.02859086
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89516112
20Proteasome_Homo sapiens_hsa030501.89375369
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88214249
22RNA degradation_Homo sapiens_hsa030181.86875956
23Selenocompound metabolism_Homo sapiens_hsa004501.78725640
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61041086
25Herpes simplex infection_Homo sapiens_hsa051681.58265295
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.55666476
27Oxidative phosphorylation_Homo sapiens_hsa001901.53001240
28Parkinsons disease_Homo sapiens_hsa050121.52168789
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49999549
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.48147141
31Fatty acid elongation_Homo sapiens_hsa000621.38477336
32Butanoate metabolism_Homo sapiens_hsa006501.29633084
33Purine metabolism_Homo sapiens_hsa002301.27583063
34Steroid biosynthesis_Homo sapiens_hsa001001.23464756
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23228789
36Phototransduction_Homo sapiens_hsa047441.22910112
37p53 signaling pathway_Homo sapiens_hsa041151.20227484
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18234453
39Measles_Homo sapiens_hsa051621.17297930
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.16907952
41Huntingtons disease_Homo sapiens_hsa050161.16117868
42Hematopoietic cell lineage_Homo sapiens_hsa046401.13531271
43mRNA surveillance pathway_Homo sapiens_hsa030151.13016410
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08482104
45Primary immunodeficiency_Homo sapiens_hsa053401.06500269
46Folate biosynthesis_Homo sapiens_hsa007901.06283524
47Protein export_Homo sapiens_hsa030601.04038350
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03954271
49Systemic lupus erythematosus_Homo sapiens_hsa053221.03004488
50Pyruvate metabolism_Homo sapiens_hsa006201.01062524
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97711678
52Peroxisome_Homo sapiens_hsa041460.92791237
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91194549
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90901674
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89432915
56Allograft rejection_Homo sapiens_hsa053300.86368903
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86120411
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85997039
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85883559
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85235676
61Epstein-Barr virus infection_Homo sapiens_hsa051690.84563011
62Nitrogen metabolism_Homo sapiens_hsa009100.83928124
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81568234
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81483626
65Tryptophan metabolism_Homo sapiens_hsa003800.80816976
66Autoimmune thyroid disease_Homo sapiens_hsa053200.80564824
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79817204
68Graft-versus-host disease_Homo sapiens_hsa053320.79589998
69Viral carcinogenesis_Homo sapiens_hsa052030.76795721
70Caffeine metabolism_Homo sapiens_hsa002320.76690410
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76433125
72Leishmaniasis_Homo sapiens_hsa051400.73896637
73HTLV-I infection_Homo sapiens_hsa051660.73652363
74Notch signaling pathway_Homo sapiens_hsa043300.73153068
75Influenza A_Homo sapiens_hsa051640.72687406
76Legionellosis_Homo sapiens_hsa051340.71877418
77Metabolic pathways_Homo sapiens_hsa011000.71155669
78Sulfur metabolism_Homo sapiens_hsa009200.70760704
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.70094747
80Oocyte meiosis_Homo sapiens_hsa041140.68024531
81Alzheimers disease_Homo sapiens_hsa050100.66653202
82Glutathione metabolism_Homo sapiens_hsa004800.66146578
83Linoleic acid metabolism_Homo sapiens_hsa005910.65034126
84Antigen processing and presentation_Homo sapiens_hsa046120.64776978
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64712348
86Apoptosis_Homo sapiens_hsa042100.61397904
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60011893
88Hepatitis B_Homo sapiens_hsa051610.59683381
89Fatty acid metabolism_Homo sapiens_hsa012120.58915386
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58510615
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57396367
92Other glycan degradation_Homo sapiens_hsa005110.56858345
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56715494
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55397250
95Arachidonic acid metabolism_Homo sapiens_hsa005900.55126328
96TNF signaling pathway_Homo sapiens_hsa046680.53427511
97Ether lipid metabolism_Homo sapiens_hsa005650.52842033
98Asthma_Homo sapiens_hsa053100.52027586
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50710594
100Sulfur relay system_Homo sapiens_hsa041220.50015333
101Olfactory transduction_Homo sapiens_hsa047400.49115421
102Rheumatoid arthritis_Homo sapiens_hsa053230.48841394
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48270484
104Retinol metabolism_Homo sapiens_hsa008300.48234376
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47763952
106Basal cell carcinoma_Homo sapiens_hsa052170.47352115
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.46920243
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45955582
109Small cell lung cancer_Homo sapiens_hsa052220.45525999
110beta-Alanine metabolism_Homo sapiens_hsa004100.45372330
111Acute myeloid leukemia_Homo sapiens_hsa052210.44701215
112Sphingolipid metabolism_Homo sapiens_hsa006000.44600041
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44297574
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43203561
115Chemical carcinogenesis_Homo sapiens_hsa052040.42853462
116Fatty acid degradation_Homo sapiens_hsa000710.42333856
117Carbon metabolism_Homo sapiens_hsa012000.42274863
118MicroRNAs in cancer_Homo sapiens_hsa052060.41836417
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40581748
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40391740
121Regulation of autophagy_Homo sapiens_hsa041400.40156865
122Melanoma_Homo sapiens_hsa052180.39892224
123TGF-beta signaling pathway_Homo sapiens_hsa043500.38889313
124Osteoclast differentiation_Homo sapiens_hsa043800.38793931
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38582409
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38513858
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.38476850
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.37072924
129N-Glycan biosynthesis_Homo sapiens_hsa005100.36960687
130Vitamin B6 metabolism_Homo sapiens_hsa007500.36457972
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36292066
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35915641
133Alcoholism_Homo sapiens_hsa050340.35559665
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35184630
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34979558
136Biosynthesis of amino acids_Homo sapiens_hsa012300.34638505
137Malaria_Homo sapiens_hsa051440.31540903
138Vitamin digestion and absorption_Homo sapiens_hsa049770.31301099
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.30649337
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30171548
141Pathways in cancer_Homo sapiens_hsa052000.29897298
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.29101777
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28738851
144Wnt signaling pathway_Homo sapiens_hsa043100.28076252
145Type I diabetes mellitus_Homo sapiens_hsa049400.26814465
146Tuberculosis_Homo sapiens_hsa051520.25741842
147Hepatitis C_Homo sapiens_hsa051600.24555965
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23650822
149Colorectal cancer_Homo sapiens_hsa052100.23583981
150Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23238760
151African trypanosomiasis_Homo sapiens_hsa051430.22418623
152Prostate cancer_Homo sapiens_hsa052150.22379592
153PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21640027
154Circadian rhythm_Homo sapiens_hsa047100.20984856
155Chronic myeloid leukemia_Homo sapiens_hsa052200.20832815

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