SHROOM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SHROOM family members play diverse roles in the development of the nervous system and other tissues (Hagens et al., 2006 [PubMed 16615870]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.66106119
2L-phenylalanine catabolic process (GO:0006559)7.66106119
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.27065487
4L-phenylalanine metabolic process (GO:0006558)7.27065487
5aromatic amino acid family catabolic process (GO:0009074)6.85472611
6indole-containing compound catabolic process (GO:0042436)6.20296602
7indolalkylamine catabolic process (GO:0046218)6.20296602
8tryptophan catabolic process (GO:0006569)6.20296602
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.06471655
10kynurenine metabolic process (GO:0070189)5.89354469
11bile acid biosynthetic process (GO:0006699)5.87275537
12tryptophan metabolic process (GO:0006568)5.85144342
13alpha-linolenic acid metabolic process (GO:0036109)5.52400980
14high-density lipoprotein particle remodeling (GO:0034375)5.51075719
15glyoxylate metabolic process (GO:0046487)5.47048967
16urea cycle (GO:0000050)5.41512136
17urea metabolic process (GO:0019627)5.41512136
18negative regulation of fibrinolysis (GO:0051918)5.41011220
19cysteine metabolic process (GO:0006534)5.34261370
20sulfur amino acid catabolic process (GO:0000098)5.32630430
21protein carboxylation (GO:0018214)5.26529194
22peptidyl-glutamic acid carboxylation (GO:0017187)5.26529194
23regulation of fibrinolysis (GO:0051917)5.24378060
24regulation of protein activation cascade (GO:2000257)5.15298313
25serine family amino acid catabolic process (GO:0009071)5.03678297
26bile acid metabolic process (GO:0008206)5.03549842
27complement activation, alternative pathway (GO:0006957)5.00211939
28nitrogen cycle metabolic process (GO:0071941)4.98940064
29aromatic amino acid family metabolic process (GO:0009072)4.96741117
30regulation of complement activation (GO:0030449)4.79017765
31tyrosine metabolic process (GO:0006570)4.78437306
32reverse cholesterol transport (GO:0043691)4.77320521
33homocysteine metabolic process (GO:0050667)4.73960090
34regulation of cholesterol esterification (GO:0010872)4.72591009
35regulation of triglyceride catabolic process (GO:0010896)4.71449437
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.65756900
37plasma lipoprotein particle remodeling (GO:0034369)4.62322203
38protein-lipid complex remodeling (GO:0034368)4.62322203
39macromolecular complex remodeling (GO:0034367)4.62322203
40alpha-amino acid catabolic process (GO:1901606)4.61907009
41coenzyme catabolic process (GO:0009109)4.56334635
42triglyceride homeostasis (GO:0070328)4.52537152
43acylglycerol homeostasis (GO:0055090)4.52537152
44amine catabolic process (GO:0009310)4.46256458
45cellular biogenic amine catabolic process (GO:0042402)4.46256458
46negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.39731584
47indolalkylamine metabolic process (GO:0006586)4.39602579
48amino-acid betaine metabolic process (GO:0006577)4.34629023
49negative regulation of cholesterol transport (GO:0032375)4.33624226
50negative regulation of sterol transport (GO:0032372)4.33624226
51phospholipid efflux (GO:0033700)4.31799908
52positive regulation of fatty acid beta-oxidation (GO:0032000)4.26950551
53cellular amino acid catabolic process (GO:0009063)4.26516581
54bile acid and bile salt transport (GO:0015721)4.26169767
55imidazole-containing compound metabolic process (GO:0052803)4.23909292
56positive regulation of protein kinase C signaling (GO:0090037)4.23042872
57lysine catabolic process (GO:0006554)4.21681228
58lysine metabolic process (GO:0006553)4.21681228
59glycine metabolic process (GO:0006544)4.20566405
60glutamate metabolic process (GO:0006536)4.19390450
61plasma lipoprotein particle clearance (GO:0034381)4.17119795
62regulation of hydrogen peroxide metabolic process (GO:0010310)4.16662019
63cellular glucuronidation (GO:0052695)4.14778069
64cholesterol efflux (GO:0033344)4.12768601
65cellular modified amino acid catabolic process (GO:0042219)4.12470465
66serine family amino acid metabolic process (GO:0009069)4.07792052
67exogenous drug catabolic process (GO:0042738)4.07029893
68cellular ketone body metabolic process (GO:0046950)4.03488515
69epoxygenase P450 pathway (GO:0019373)4.03096755
70arginine metabolic process (GO:0006525)4.02559225
71benzene-containing compound metabolic process (GO:0042537)4.02140313
72serine family amino acid biosynthetic process (GO:0009070)4.00960053
73positive regulation of triglyceride metabolic process (GO:0090208)4.00290674
74flavonoid metabolic process (GO:0009812)3.97674597
75ethanol oxidation (GO:0006069)3.97380322
76aldehyde catabolic process (GO:0046185)3.94483776
77cofactor catabolic process (GO:0051187)3.89853205
78fibrinolysis (GO:0042730)3.87573406
79regulation of plasminogen activation (GO:0010755)3.87380322
80low-density lipoprotein particle remodeling (GO:0034374)3.81376948
81negative regulation of lipase activity (GO:0060192)3.81015882
82drug catabolic process (GO:0042737)3.80885433
83regulation of bile acid biosynthetic process (GO:0070857)3.77877588
84plasma lipoprotein particle assembly (GO:0034377)3.76822254
85positive regulation of lipoprotein lipase activity (GO:0051006)3.75274638
86positive regulation of triglyceride lipase activity (GO:0061365)3.75274638
87intestinal cholesterol absorption (GO:0030299)3.73639460
88very-low-density lipoprotein particle assembly (GO:0034379)3.72922331
89organic acid catabolic process (GO:0016054)3.70288849
90carboxylic acid catabolic process (GO:0046395)3.70288849
91dicarboxylic acid biosynthetic process (GO:0043650)3.70170199
92short-chain fatty acid metabolic process (GO:0046459)3.70117731
93glucuronate metabolic process (GO:0019585)3.68322822
94uronic acid metabolic process (GO:0006063)3.68322822
95cholesterol homeostasis (GO:0042632)3.66699335
96opsonization (GO:0008228)3.61911598
97sterol homeostasis (GO:0055092)3.61549148
98phospholipid homeostasis (GO:0055091)3.61454282
99NAD biosynthetic process (GO:0009435)3.60809073
100blood coagulation, intrinsic pathway (GO:0007597)3.60366108
101acetyl-CoA metabolic process (GO:0006084)3.59961256
102diacylglycerol metabolic process (GO:0046339)3.59115157
103complement activation, classical pathway (GO:0006958)3.56968980
104pyridine nucleotide biosynthetic process (GO:0019363)3.55603954
105nicotinamide nucleotide biosynthetic process (GO:0019359)3.55603954
106negative regulation of protein activation cascade (GO:2000258)3.54854415
107protein activation cascade (GO:0072376)3.54355023
108complement activation (GO:0006956)3.52183038
109positive regulation of lipid catabolic process (GO:0050996)3.51989739
110ketone body metabolic process (GO:1902224)3.49346480
111regulation of triglyceride metabolic process (GO:0090207)3.48027337
112semaphorin-plexin signaling pathway (GO:0071526)3.42334790
113positive regulation of fatty acid oxidation (GO:0046321)3.37747332
114acute-phase response (GO:0006953)3.35299169
115regulation of fatty acid beta-oxidation (GO:0031998)3.34859624
116drug metabolic process (GO:0017144)3.29876179
117alkaloid metabolic process (GO:0009820)3.21079682
118regulation of cholesterol metabolic process (GO:0090181)3.19550113
119negative regulation of cell size (GO:0045792)3.16119206
120regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.15008735
121intestinal absorption (GO:0050892)3.10693519
122regulation of cholesterol homeostasis (GO:2000188)3.09158353
123proline metabolic process (GO:0006560)3.08733113
124regulation of apoptotic cell clearance (GO:2000425)2.99200565
125ethanol metabolic process (GO:0006067)2.98230120
126phenylpropanoid metabolic process (GO:0009698)2.97795495
127positive regulation of triglyceride biosynthetic process (GO:0010867)2.97304313
128purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.96121737
1293-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.96121737
130negative regulation of hemostasis (GO:1900047)2.94430917
131negative regulation of blood coagulation (GO:0030195)2.94430917
132omega-hydroxylase P450 pathway (GO:0097267)2.94270810
133sulfate transmembrane transport (GO:1902358)2.92681931
134quaternary ammonium group transport (GO:0015697)2.89025482
135lung epithelium development (GO:0060428)2.89019754
136oxidative demethylation (GO:0070989)2.86787622
137regulation of ruffle assembly (GO:1900027)2.82726980
138plasma lipoprotein particle organization (GO:0071827)2.81418609
139positive regulation of fatty acid metabolic process (GO:0045923)2.81113751
140positive regulation of cellular amine metabolic process (GO:0033240)2.81033387
141mannose metabolic process (GO:0006013)2.79867064
142negative regulation of protein tyrosine kinase activity (GO:0061099)2.78795640
143positive regulation of histone deacetylation (GO:0031065)2.75902537
144nephron tubule morphogenesis (GO:0072078)2.75636545
145nephron epithelium morphogenesis (GO:0072088)2.75636545
146positive regulation of fatty acid biosynthetic process (GO:0045723)2.74227898
147acute inflammatory response (GO:0002526)2.71529064
148chondroitin sulfate catabolic process (GO:0030207)2.68181106
149regulation of cholesterol biosynthetic process (GO:0045540)2.67307786
150negative regulation of coagulation (GO:0050819)2.66346675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.97892158
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.83481228
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.74404556
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.25075152
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.14548974
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.90243227
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.14300270
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.92604004
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.76799958
10LXR_22292898_ChIP-Seq_THP-1_Human2.91201866
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.76025447
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50842975
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.42562170
14DROSHA_22980978_ChIP-Seq_HELA_Human2.29944581
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.23821151
16* RACK7_27058665_Chip-Seq_MCF-7_Human2.14580037
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.13975649
18P68_20966046_ChIP-Seq_HELA_Human2.13411768
19CTCF_27219007_Chip-Seq_Bcells_Human2.00709091
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3111557
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.96428091
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89454467
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.89272380
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84320417
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.79447302
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71856957
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.71371171
28HTT_18923047_ChIP-ChIP_STHdh_Human1.71303165
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66910873
30SMC4_20622854_ChIP-Seq_HELA_Human1.65474748
31SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.64864135
32* FOXA2_19822575_ChIP-Seq_HepG2_Human1.64314574
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63788281
34BCL6_27268052_Chip-Seq_Bcells_Human1.62790666
35CREB1_26743006_Chip-Seq_LNCaP_Human1.59964802
36* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55916372
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55543838
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.55113842
39* EZH2_27294783_Chip-Seq_ESCs_Mouse1.52530613
40* KDM2B_26808549_Chip-Seq_K562_Human1.51486702
41E2F1_20622854_ChIP-Seq_HELA_Human1.50657031
42SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.49894803
43BCOR_27268052_Chip-Seq_Bcells_Human1.49479681
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47106931
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.43031979
46UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42539712
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42447105
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42408395
49CLOCK_20551151_ChIP-Seq_293T_Human1.41581959
50HNF4A_19822575_ChIP-Seq_HepG2_Human1.38797345
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.38149498
52* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36025482
53CTCF_20526341_ChIP-Seq_ESCs_Human1.33524185
54PHF8_20622854_ChIP-Seq_HELA_Human1.33183767
55SA1_27219007_Chip-Seq_Bcells_Human1.33015702
56KDM2B_26808549_Chip-Seq_DND41_Human1.30826536
57TP63_22573176_ChIP-Seq_HFKS_Human1.27640715
58ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23005819
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22634538
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21815666
61TP53_22127205_ChIP-Seq_IMR90_Human1.21487077
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21263694
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20622668
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17659773
65* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16754983
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16254086
67MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15428009
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15086212
69TET1_21490601_ChIP-Seq_MESCs_Mouse1.12473655
70RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10396188
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.09410370
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08992730
73ERA_21632823_ChIP-Seq_H3396_Human1.06834221
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05842663
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04364395
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04092884
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03611160
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02666462
79OCT4_19829295_ChIP-Seq_ESCs_Human1.02557094
80JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02324113
81* TCF7_22412390_ChIP-Seq_EML_Mouse1.02222652
82MYC_27129775_Chip-Seq_CORNEA_Mouse1.00128736
83EED_16625203_ChIP-ChIP_MESCs_Mouse0.99979950
84STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99640952
85NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98881547
86* GATA4_25053715_ChIP-Seq_YYC3_Human0.98775799
87TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98014748
88ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97789257
89SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96855850
90GATA1_22025678_ChIP-Seq_K562_Human0.96754756
91NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96690447
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96690447
93VDR_21846776_ChIP-Seq_THP-1_Human0.95085492
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94947298
95ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94504900
96CTCF_26484167_Chip-Seq_Bcells_Mouse0.94388763
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92791035
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92473690
99ESR1_21235772_ChIP-Seq_MCF-7_Human0.92171689
100TP53_23651856_ChIP-Seq_MEFs_Mouse0.91577054
101ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91344497
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88875201
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85447727
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82584880
105AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80319911
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76636942
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76432469
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75103646
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73368260
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73049033
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69583588
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.68968032
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.66935934
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66380825
115SOX2_20726797_ChIP-Seq_SW620_Human0.66190638
116RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65761851
117FOXA1_25552417_ChIP-Seq_VCAP_Human0.65179044
118CBP_21632823_ChIP-Seq_H3396_Human0.62531353
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61829733
120IRF8_22096565_ChIP-ChIP_GC-B_Human0.61641931
121RARB_24833708_ChIP-Seq_LIVER_Mouse0.61385179
122BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60736829
123* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.59306948
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.59011687
125TAF15_26573619_Chip-Seq_HEK293_Human0.58924703
126AR_20517297_ChIP-Seq_VCAP_Human0.56643349
127STAT1_17558387_ChIP-Seq_HELA_Human0.56561332
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.56485712
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.55513258
130TRIM28_21343339_ChIP-Seq_HEK293_Human0.54775705
131CEBPB_22108803_ChIP-Seq_LS180_Human0.54680779
132PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.54647731
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.53647082
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.53516551
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.53346369
136GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.53223471
137MYC_19915707_ChIP-ChIP_AK7_Human0.53199706
138FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.53162742
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.52971897
140EGR1_19032775_ChIP-ChIP_M12_Human0.50155799
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.50122392
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.48040481
143ZNF217_24962896_ChIP-Seq_MCF-7_Human0.47670274
144IRF1_19129219_ChIP-ChIP_H3396_Human0.47380872
145P53_21459846_ChIP-Seq_SAOS-2_Human0.46919763
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.46482811
147CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.46273368
148FOXH1_21741376_ChIP-Seq_EPCs_Human0.45746360
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.45457980
150GATA2_21666600_ChIP-Seq_HMVEC_Human0.45319597
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.44815186
152GATA3_24758297_ChIP-Seq_MCF-7_Human0.44567168
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.44317412
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44017097
155NCOR_22424771_ChIP-Seq_293T_Human0.43944511
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.43688696
157ZNF263_19887448_ChIP-Seq_K562_Human0.43677196
158PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43072711
159CDX2_19796622_ChIP-Seq_MESCs_Mouse0.41491095
160* CDX2_22108803_ChIP-Seq_LS180_Human0.41263398
161BCAT_22108803_ChIP-Seq_LS180_Human0.41099863
162GATA6_25053715_ChIP-Seq_YYC3_Human0.40439139
163NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.40380933
164SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40069005
165CRX_20693478_ChIP-Seq_RETINA_Mouse0.39624167
166PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.38792778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.08167626
2MP0005360_urolithiasis7.25045523
3MP0005085_abnormal_gallbladder_physiolo6.40149786
4MP0005365_abnormal_bile_salt6.12764637
5MP0008875_abnormal_xenobiotic_pharmacok5.03916499
6MP0003806_abnormal_nucleotide_metabolis4.19967635
7MP0003252_abnormal_bile_duct3.91866481
8MP0010329_abnormal_lipoprotein_level3.49247330
9MP0005083_abnormal_biliary_tract3.29903987
10MP0002249_abnormal_larynx_morphology3.17083940
11MP0003195_calcinosis2.95481589
12MP0009840_abnormal_foam_cell2.91016325
13MP0001666_abnormal_nutrient_absorption2.87924271
14MP0000678_abnormal_parathyroid_gland2.85321231
15MP0005332_abnormal_amino_acid2.80023829
16MP0003879_abnormal_hair_cell2.58553322
17MP0003172_abnormal_lysosome_physiology2.58045780
18MP0002138_abnormal_hepatobiliary_system2.22323488
19MP0005058_abnormal_lysosome_morphology2.22313988
20MP0004019_abnormal_vitamin_homeostasis2.18996832
21MP0000013_abnormal_adipose_tissue2.18328991
22MP0002118_abnormal_lipid_homeostasis2.11848247
23MP0000609_abnormal_liver_physiology2.08514062
24MP0003868_abnormal_feces_composition1.96104490
25MP0003191_abnormal_cellular_cholesterol1.83005736
26MP0001849_ear_inflammation1.82539979
27MP0005319_abnormal_enzyme/_coenzyme1.78852891
28MP0009697_abnormal_copulation1.68980355
29MP0001764_abnormal_homeostasis1.68847569
30MP0001502_abnormal_circadian_rhythm1.64630237
31MP0009780_abnormal_chondrocyte_physiolo1.62272457
32MP0000003_abnormal_adipose_tissue1.58039304
33MP0005584_abnormal_enzyme/coenzyme_acti1.52629109
34MP0005451_abnormal_body_composition1.48793684
35MP0002933_joint_inflammation1.43826584
36MP0003186_abnormal_redox_activity1.40046707
37MP0003011_delayed_dark_adaptation1.37915607
38MP0001765_abnormal_ion_homeostasis1.33929499
39MP0005409_darkened_coat_color1.32544738
40MP0005647_abnormal_sex_gland1.24836856
41MP0003656_abnormal_erythrocyte_physiolo1.24366997
42MP0009643_abnormal_urine_homeostasis1.23507009
43MP0002932_abnormal_joint_morphology1.22314801
44MP0002089_abnormal_postnatal_growth/wei1.20954246
45MP0005084_abnormal_gallbladder_morpholo1.15764430
46MP0000767_abnormal_smooth_muscle1.15131370
47MP0001348_abnormal_lacrimal_gland1.12786099
48MP0000598_abnormal_liver_morphology1.11805154
49MP0009764_decreased_sensitivity_to1.09303748
50MP0004858_abnormal_nervous_system1.09269653
51MP0003283_abnormal_digestive_organ1.08944659
52MP0000467_abnormal_esophagus_morphology1.04240081
53MP0001664_abnormal_digestion1.03950290
54MP0005408_hypopigmentation1.03544451
55MP0003183_abnormal_peptide_metabolism1.01800664
56MP0000604_amyloidosis1.01043269
57MP0000681_abnormal_thyroid_gland1.00460885
58MP0005220_abnormal_exocrine_pancreas0.99716285
59MP0005636_abnormal_mineral_homeostasis0.99446818
60MP0006292_abnormal_olfactory_placode0.98477645
61MP0009763_increased_sensitivity_to0.97833843
62MP0010368_abnormal_lymphatic_system0.96537895
63MP0003705_abnormal_hypodermis_morpholog0.94548824
64MP0001873_stomach_inflammation0.94247636
65MP0001958_emphysema0.93827963
66MP0002254_reproductive_system_inflammat0.93078616
67MP0005375_adipose_tissue_phenotype0.91890893
68MP0005646_abnormal_pituitary_gland0.89317177
69MP0005503_abnormal_tendon_morphology0.85966019
70MP0003938_abnormal_ear_development0.85800214
71MP0009642_abnormal_blood_homeostasis0.85183725
72MP0002876_abnormal_thyroid_physiology0.83798687
73MP0008469_abnormal_protein_level0.83213976
74MP0002234_abnormal_pharynx_morphology0.82265733
75MP0009765_abnormal_xenobiotic_induced0.80890193
76MP0006138_congestive_heart_failure0.80245183
77MP0003690_abnormal_glial_cell0.79230144
78MP0003045_fibrosis0.77169136
79MP0005376_homeostasis/metabolism_phenot0.76587264
80MP0003137_abnormal_impulse_conducting0.75810352
81MP0005670_abnormal_white_adipose0.75455731
82MP0004133_heterotaxia0.74514116
83MP0004145_abnormal_muscle_electrophysio0.72243011
84MP0002822_catalepsy0.71332512
85MP0002078_abnormal_glucose_homeostasis0.71262979
86MP0000538_abnormal_urinary_bladder0.70307570
87MP0004381_abnormal_hair_follicle0.69651228
88MP0000026_abnormal_inner_ear0.68838610
89MP0005334_abnormal_fat_pad0.68584197
90MP0003718_maternal_effect0.68515807
91MP0001756_abnormal_urination0.67671209
92MP0005076_abnormal_cell_differentiation0.67309488
93MP0005167_abnormal_blood-brain_barrier0.67001796
94MP0000639_abnormal_adrenal_gland0.66645436
95MP0002282_abnormal_trachea_morphology0.66173426
96MP0001881_abnormal_mammary_gland0.65712115
97MP0006036_abnormal_mitochondrial_physio0.65393625
98MP0002166_altered_tumor_susceptibility0.65287261
99MP0000163_abnormal_cartilage_morphology0.64837402
100MP0000537_abnormal_urethra_morphology0.64813411
101MP0003329_amyloid_beta_deposits0.64807297
102MP0009053_abnormal_anal_canal0.64621708
103MP0001661_extended_life_span0.63437962
104MP0005377_hearing/vestibular/ear_phenot0.62710311
105MP0003878_abnormal_ear_physiology0.62710311
106MP0005023_abnormal_wound_healing0.62451847
107MP0009384_cardiac_valve_regurgitation0.61304543
108MP0001501_abnormal_sleep_pattern0.59203457
109MP0003119_abnormal_digestive_system0.58910940
110MP0004782_abnormal_surfactant_physiolog0.58886934
111MP0005395_other_phenotype0.58440839
112MP0002970_abnormal_white_adipose0.58183707
113MP0001485_abnormal_pinna_reflex0.58127250
114MP0002971_abnormal_brown_adipose0.57378913
115MP0005535_abnormal_body_temperature0.56975913
116MP0004264_abnormal_extraembryonic_tissu0.56739480
117MP0003279_aneurysm0.56632778
118MP0008260_abnormal_autophagy0.55705221
119MP0000751_myopathy0.54679963
120MP0000371_diluted_coat_color0.53982481
121MP0003942_abnormal_urinary_system0.53806532
122MP0002928_abnormal_bile_duct0.50468076
123MP0005266_abnormal_metabolism0.49903998
124MP0000579_abnormal_nail_morphology0.49188861
125MP0003724_increased_susceptibility_to0.48795053
126MP0005448_abnormal_energy_balance0.48791729
127MP0000566_synostosis0.48297783
128MP0005464_abnormal_platelet_physiology0.47278169
129MP0003075_altered_response_to0.46770743
130MP0002136_abnormal_kidney_physiology0.45684513
131MP0003638_abnormal_response/metabolism_0.45424359
132MP0004130_abnormal_muscle_cell0.43282678
133MP0008873_increased_physiological_sensi0.40881534
134MP0005248_abnormal_Harderian_gland0.39227492
135MP0000230_abnormal_systemic_arterial0.37632670
136MP0005166_decreased_susceptibility_to0.37417721
137MP0006035_abnormal_mitochondrial_morpho0.37390666
138MP0002796_impaired_skin_barrier0.37059697
139MP0002295_abnormal_pulmonary_circulatio0.36869118
140MP0004043_abnormal_pH_regulation0.36752156
141MP0008874_decreased_physiological_sensi0.36626843
142MP0003953_abnormal_hormone_level0.36623505
143MP0005164_abnormal_response_to0.36565512
144MP0010234_abnormal_vibrissa_follicle0.35363401
145MP0002060_abnormal_skin_morphology0.34926969
146MP0001243_abnormal_dermal_layer0.34823507
147MP0002168_other_aberrant_phenotype0.33310475
148MP0000249_abnormal_blood_vessel0.31808743
149MP0008872_abnormal_physiological_respon0.31255182
150MP0002132_abnormal_respiratory_system0.30959781
151MP0004883_abnormal_blood_vessel0.30532954
152MP0003453_abnormal_keratinocyte_physiol0.30198779
153MP0000427_abnormal_hair_cycle0.29883483
154MP0009672_abnormal_birth_weight0.28662988
155MP0005595_abnormal_vascular_smooth0.27367813
156MP0002090_abnormal_vision0.25881534

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.46509079
2Intrahepatic cholestasis (HP:0001406)7.30464603
3Deep venous thrombosis (HP:0002625)7.30221319
4Prolonged partial thromboplastin time (HP:0003645)6.64201455
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.63846702
6Hypobetalipoproteinemia (HP:0003563)6.23445512
7Xanthomatosis (HP:0000991)6.14048318
8J-shaped sella turcica (HP:0002680)5.65901743
9Hyperlipoproteinemia (HP:0010980)5.60293403
10Complement deficiency (HP:0004431)5.03394900
11Joint hemorrhage (HP:0005261)4.75531872
12Obstructive sleep apnea (HP:0002870)4.75290557
13Hypolipoproteinemia (HP:0010981)4.60538252
14Hyperglycinemia (HP:0002154)4.53789480
15Epidermoid cyst (HP:0200040)4.50103074
16Abnormality of methionine metabolism (HP:0010901)4.49202462
17Abnormality of the common coagulation pathway (HP:0010990)4.49110308
18Hyperammonemia (HP:0001987)4.45864301
19Broad face (HP:0000283)4.38379555
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.37938002
21Fat malabsorption (HP:0002630)4.31142644
22Cervical subluxation (HP:0003308)4.31004326
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26167700
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.21896837
25Stridor (HP:0010307)4.16401279
26Abnormality of glutamine family amino acid metabolism (HP:0010902)4.15396323
27Lymphangioma (HP:0100764)4.11227406
28Hypoalphalipoproteinemia (HP:0003233)4.00956997
29Ketosis (HP:0001946)3.99828366
30Abnormality of glycine metabolism (HP:0010895)3.98406626
31Abnormality of serine family amino acid metabolism (HP:0010894)3.98406626
32Hyperglycinuria (HP:0003108)3.94965580
33Abnormality of the intrinsic pathway (HP:0010989)3.84525560
34Conjugated hyperbilirubinemia (HP:0002908)3.83361276
35Abnormality of pyrimidine metabolism (HP:0004353)3.79617569
36Aortic regurgitation (HP:0001659)3.64516901
37Hypercholesterolemia (HP:0003124)3.60757530
38Hypoglycemic coma (HP:0001325)3.60387167
39Abnormality of complement system (HP:0005339)3.59853518
40Cerebral palsy (HP:0100021)3.57090347
41Steatorrhea (HP:0002570)3.40873633
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36589972
43Hyperbilirubinemia (HP:0002904)3.20842283
44Abnormality of fatty-acid metabolism (HP:0004359)3.18478573
45Abnormality of serum amino acid levels (HP:0003112)3.13473131
46Spontaneous abortion (HP:0005268)3.09116630
47Abnormality of nucleobase metabolism (HP:0010932)3.07474926
48Biconcave vertebral bodies (HP:0004586)3.05300400
49Myocardial infarction (HP:0001658)2.98807994
50Mucopolysacchariduria (HP:0008155)2.98454316
51Urinary glycosaminoglycan excretion (HP:0003541)2.98454316
52Delayed CNS myelination (HP:0002188)2.97552244
53Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.91013439
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.90792116
55Abnormality of polysaccharide metabolism (HP:0011012)2.90792116
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.90792116
57Hepatocellular carcinoma (HP:0001402)2.90600918
58Vascular calcification (HP:0004934)2.80266090
59Joint stiffness (HP:0001387)2.80064955
60Bronchomalacia (HP:0002780)2.76614691
61Thin bony cortex (HP:0002753)2.72829839
62Neoplasm of the heart (HP:0100544)2.72340566
63Abnormality of purine metabolism (HP:0004352)2.71403604
64Aplasia/hypoplasia of the femur (HP:0005613)2.71352795
65Metabolic acidosis (HP:0001942)2.71299728
66Deformed sella turcica (HP:0002681)2.70160124
67Hypochromic microcytic anemia (HP:0004840)2.70136474
68Ketoacidosis (HP:0001993)2.69611427
69Lethargy (HP:0001254)2.64613053
70Flared iliac wings (HP:0002869)2.64010825
71Skin nodule (HP:0200036)2.61322532
72Dysostosis multiplex (HP:0000943)2.53990409
73Systemic lupus erythematosus (HP:0002725)2.52484432
74Gout (HP:0001997)2.52473723
75Hypoglycemic seizures (HP:0002173)2.52145584
76Nephritis (HP:0000123)2.51549864
77Neurodegeneration (HP:0002180)2.48858257
78Cardiovascular calcification (HP:0011915)2.48726589
79Acanthocytosis (HP:0001927)2.42512582
80Nuclear cataract (HP:0100018)2.40992198
81Cerebral edema (HP:0002181)2.40844546
82Dicarboxylic aciduria (HP:0003215)2.40518119
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40518119
84Abnormal gallbladder morphology (HP:0012437)2.38482584
85Enlarged kidneys (HP:0000105)2.37196752
86Malnutrition (HP:0004395)2.36731470
87Esophageal varix (HP:0002040)2.35619519
88Rectal prolapse (HP:0002035)2.34400545
89Ependymoma (HP:0002888)2.34201079
90Cholecystitis (HP:0001082)2.34102310
91Abnormal gallbladder physiology (HP:0012438)2.34102310
92Amyloidosis (HP:0011034)2.33028418
93Opisthotonus (HP:0002179)2.31472493
94Visceral angiomatosis (HP:0100761)2.28489218
95Vitreoretinal degeneration (HP:0000655)2.26754501
96Mitral stenosis (HP:0001718)2.26259150
97Cholelithiasis (HP:0001081)2.26035943
98Gingival bleeding (HP:0000225)2.25693761
99Irritability (HP:0000737)2.25608873
100Spastic diplegia (HP:0001264)2.25326655
101Brushfield spots (HP:0001088)2.25302790
102Glomerulonephritis (HP:0000099)2.25036689
103Cerebral aneurysm (HP:0004944)2.24069507
104Hypophosphatemic rickets (HP:0004912)2.22072088
105Menorrhagia (HP:0000132)2.21633390
106Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.21138938
107Rickets (HP:0002748)2.19534863
108Pancreatitis (HP:0001733)2.19251065
109Hamartoma of the eye (HP:0010568)2.18167130
110Hypoplasia of the odontoid process (HP:0003311)2.14179418
111Sleep apnea (HP:0010535)2.13223833
112Recurrent gram-negative bacterial infections (HP:0005420)2.09512170
113Neonatal onset (HP:0003623)2.09142514
114Decreased circulating renin level (HP:0003351)2.04642850
115Vomiting (HP:0002013)2.02868917
116Hydroxyprolinuria (HP:0003080)2.01997369
117Abnormality of proline metabolism (HP:0010907)2.01997369
118Abnormality of lateral ventricle (HP:0030047)2.01347502
119Prolonged QT interval (HP:0001657)2.01020846
120Abnormality of transition element cation homeostasis (HP:0011030)2.00749771
121Hemorrhage of the eye (HP:0011885)1.99883707
122Spinal canal stenosis (HP:0003416)1.99440468
123Hemangiomatosis (HP:0007461)1.99255151
124Renal cortical cysts (HP:0000803)1.98932284
125Abnormality of the gallbladder (HP:0005264)1.96871218
126Hyperinsulinemic hypoglycemia (HP:0000825)1.94478225
127Severe Myopia (HP:0011003)1.93894850
128Abnormality of iron homeostasis (HP:0011031)1.92430454
129Sensorimotor neuropathy (HP:0007141)1.92237738
130Abnormal enzyme/coenzyme activity (HP:0012379)1.91488810
131Thrombophlebitis (HP:0004418)1.89929699
132Genetic anticipation (HP:0003743)1.88707469
133Flat acetabular roof (HP:0003180)1.85169161
134Broad metatarsal (HP:0001783)1.84823563
135Aortic valve stenosis (HP:0001650)1.83826161
136Generalized aminoaciduria (HP:0002909)1.82792581
137Alkalosis (HP:0001948)1.82752684
138Hypophosphatemia (HP:0002148)1.82149592
139Aneurysm (HP:0002617)1.81589877
140Abnormality of vitamin metabolism (HP:0100508)1.81125669
141Poikilocytosis (HP:0004447)1.80714826
142Elevated hepatic transaminases (HP:0002910)1.79404152
143Abnormality of the sella turcica (HP:0002679)1.79236251
144Elevated alkaline phosphatase (HP:0003155)1.76288891
145Abnormality of the femoral head (HP:0003368)1.75896127
146Bradycardia (HP:0001662)1.74911269
147Confusion (HP:0001289)1.74715147
148Abnormality of the odontoid process (HP:0003310)1.73342442
149Pigmentary retinal degeneration (HP:0001146)1.73288800
150Nonimmune hydrops fetalis (HP:0001790)1.73056529
151Shallow orbits (HP:0000586)1.72749736
152Abnormality of urine glucose concentration (HP:0011016)1.71693935
153Glycosuria (HP:0003076)1.71693935
154Abnormal atrioventricular conduction (HP:0005150)1.71591888
155Status epilepticus (HP:0002133)1.71389799
156Abnormality of the 1st metacarpal (HP:0010009)1.71158167
157Hypertriglyceridemia (HP:0002155)1.70706976
158Generalized hypopigmentation of hair (HP:0011358)1.70264195
159Atelectasis (HP:0100750)1.69633026
160Protuberant abdomen (HP:0001538)1.69443579
161Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.65785985
162Short 1st metacarpal (HP:0010034)1.65785985
163Focal segmental glomerulosclerosis (HP:0000097)1.65465394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.03348467
2SIK14.68208832
3FGFR43.88564934
4ERN13.48166260
5TAOK33.39304177
6INSRR3.15014374
7TNK23.11125182
8FRK2.58655025
9ERBB42.48578486
10WNK42.46229264
11NME12.44151975
12NTRK32.42094224
13PRKD22.24778601
14PIK3CG2.16872231
15AKT32.00785539
16MAP2K41.90246853
17DAPK21.89815924
18MST1R1.85538244
19STK38L1.77737274
20FGFR21.75950308
21LATS11.70336814
22PKN21.67476377
23IRAK31.62853218
24PTK61.61571645
25KDR1.58396559
26ICK1.56638262
27MARK21.54526651
28EPHB11.49888299
29PINK11.40218013
30NEK91.39829011
31RPS6KA21.38178789
32ABL21.37828053
33MAPK111.36114911
34LMTK21.35856453
35SIK21.31040204
36TYK21.26947942
37FLT31.25382103
38MAPK151.24122821
39MAP3K141.22626401
40MET1.21330823
41PRKCI1.19749600
42EEF2K1.16307131
43CDC42BPA1.16283295
44SMG11.12263741
45CAMK2G1.06016009
46PRKAA21.04716583
47GRK11.02918206
48RPS6KA61.01498464
49PRKG20.97974754
50TIE10.97748334
51MAP3K60.96877097
52HIPK20.96448676
53JAK20.96427046
54RPS6KL10.96322113
55RPS6KC10.96322113
56ERBB20.95590265
57PIK3CA0.93217222
58MAP3K70.91905765
59CAMKK10.87619791
60MAPKAPK30.86804473
61PRKCZ0.85765588
62TRIB30.85002885
63CHUK0.81562182
64PTK20.79402790
65DDR20.79041830
66EPHA40.78955474
67PBK0.78715076
68MAPK70.78569664
69ADRBK20.77129379
70EPHA20.75392836
71TBK10.75259836
72TLK10.74774566
73MATK0.74355746
74MTOR0.73287807
75JAK10.72747580
76MUSK0.69134471
77MAPK40.68449372
78STK380.68311631
79SGK2230.67872434
80SGK4940.67872434
81MAP4K10.66323930
82PKN10.65926697
83CAMK10.65673147
84TESK10.65337087
85STK390.65132672
86PDGFRA0.64939900
87CAMK1D0.62664682
88EPHB20.61974526
89PRKCQ0.61527260
90MAP2K20.60353941
91MAP2K70.60252522
92IRAK20.59910805
93MAP2K10.58088553
94MAP3K30.56851013
95GRK60.56768755
96PRKACG0.56126376
97MAPK120.56107669
98GSK3A0.55950884
99MAPK80.54070000
100PRKD30.53349511
101NUAK10.53122077
102ZAP700.52772739
103PDGFRB0.51901691
104PRKD10.51480601
105CSK0.51470740
106TGFBR20.50598388
107FGFR30.49581777
108ROCK10.49098129
109PDPK10.48297373
110MYLK0.47255942
111STK30.45427716
112SGK30.44993653
113CDK60.44874837
114IKBKB0.44760735
115RIPK10.43307221
116PAK30.43230287
117SGK20.42928342
118FER0.42162932
119IGF1R0.41360753
120DMPK0.40947970
121IRAK10.39345359
122CSNK1A1L0.38890198
123TAOK20.38180270
124PRKAA10.37786879
125PHKG10.37668399
126PHKG20.37668399
127MAPK30.37599971
128PDK10.37253749
129MAP2K60.36242764
130PRKCG0.36114008
131MAP3K110.36044511
132CSNK1G10.36041111
133DYRK1B0.35417521
134CAMK2B0.35093828
135IKBKE0.34423098
136MAPK10.34027524
137MAP2K30.33755246
138PLK40.32592083
139ABL10.32577547
140CSNK1A10.31711417
141MAPKAPK20.31696721
142OXSR10.31277903
143BMX0.30637565
144PRKCA0.28982375
145SRC0.28969266
146PRKCH0.28886947
147TAOK10.27846631
148CAMK1G0.26905064
149EPHA30.26864745
150MAP3K130.26182322
151CAMK40.25435736
152PTK2B0.22703658
153CSNK1G20.21833897
154MAP3K40.20538259

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.47336493
2Nitrogen metabolism_Homo sapiens_hsa009103.48148385
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.27068720
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19339365
5Arginine biosynthesis_Homo sapiens_hsa002203.05314407
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.82618143
7Complement and coagulation cascades_Homo sapiens_hsa046102.72530503
8Tryptophan metabolism_Homo sapiens_hsa003802.63686830
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.60865516
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55541495
11Fatty acid degradation_Homo sapiens_hsa000712.37822674
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35795657
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.19000408
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17757751
15Other glycan degradation_Homo sapiens_hsa005112.16368378
16Peroxisome_Homo sapiens_hsa041462.12915219
17Butanoate metabolism_Homo sapiens_hsa006502.07923150
18Histidine metabolism_Homo sapiens_hsa003402.01209652
19Chemical carcinogenesis_Homo sapiens_hsa052041.99639344
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.99093123
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96474330
22Caffeine metabolism_Homo sapiens_hsa002321.90344400
23Propanoate metabolism_Homo sapiens_hsa006401.89634468
24PPAR signaling pathway_Homo sapiens_hsa033201.77234097
25Retinol metabolism_Homo sapiens_hsa008301.75266480
26Fatty acid metabolism_Homo sapiens_hsa012121.74549165
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72864166
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.71877648
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69079776
30Staphylococcus aureus infection_Homo sapiens_hsa051501.68964282
31beta-Alanine metabolism_Homo sapiens_hsa004101.67163932
32Steroid biosynthesis_Homo sapiens_hsa001001.64578517
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59176690
34Sulfur metabolism_Homo sapiens_hsa009201.55626928
35Phenylalanine metabolism_Homo sapiens_hsa003601.51342509
36Selenocompound metabolism_Homo sapiens_hsa004501.49935030
37Fatty acid elongation_Homo sapiens_hsa000621.48967935
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46605042
39Bile secretion_Homo sapiens_hsa049761.43657124
40Tyrosine metabolism_Homo sapiens_hsa003501.42285149
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38461637
42Pyruvate metabolism_Homo sapiens_hsa006201.31651838
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.29136168
44Notch signaling pathway_Homo sapiens_hsa043301.27208851
45Folate biosynthesis_Homo sapiens_hsa007901.26493782
46Fat digestion and absorption_Homo sapiens_hsa049751.24043583
47Starch and sucrose metabolism_Homo sapiens_hsa005001.22912639
48ABC transporters_Homo sapiens_hsa020101.18393280
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16136984
50Biosynthesis of amino acids_Homo sapiens_hsa012301.10502046
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.08946624
52Vitamin B6 metabolism_Homo sapiens_hsa007501.04831902
53Insulin secretion_Homo sapiens_hsa049111.03982514
54Arginine and proline metabolism_Homo sapiens_hsa003301.03635217
55Vitamin digestion and absorption_Homo sapiens_hsa049771.03337913
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.99346574
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97142018
58Carbon metabolism_Homo sapiens_hsa012000.96818226
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90259581
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.82701400
61Sulfur relay system_Homo sapiens_hsa041220.82350620
62One carbon pool by folate_Homo sapiens_hsa006700.77365558
63Lysine degradation_Homo sapiens_hsa003100.73999972
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72812037
65Glycerolipid metabolism_Homo sapiens_hsa005610.70699831
66Glutathione metabolism_Homo sapiens_hsa004800.65781035
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65680468
68Fatty acid biosynthesis_Homo sapiens_hsa000610.64869651
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61048101
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57055676
71ECM-receptor interaction_Homo sapiens_hsa045120.56194135
72Cocaine addiction_Homo sapiens_hsa050300.54008945
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50107261
74Metabolic pathways_Homo sapiens_hsa011000.49653400
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45624194
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.43886071
77Choline metabolism in cancer_Homo sapiens_hsa052310.43191699
78Pentose phosphate pathway_Homo sapiens_hsa000300.42621239
79Linoleic acid metabolism_Homo sapiens_hsa005910.40717689
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37945142
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34477604
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33606652
83Type II diabetes mellitus_Homo sapiens_hsa049300.31591329
84Sphingolipid metabolism_Homo sapiens_hsa006000.31149861
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31044414
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27982252
87Prion diseases_Homo sapiens_hsa050200.27667334
88Serotonergic synapse_Homo sapiens_hsa047260.27481173
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25984178
90Renin secretion_Homo sapiens_hsa049240.25644812
91GnRH signaling pathway_Homo sapiens_hsa049120.25365457
92Galactose metabolism_Homo sapiens_hsa000520.25208565
93Axon guidance_Homo sapiens_hsa043600.25046722
94VEGF signaling pathway_Homo sapiens_hsa043700.23370445
95Pancreatic secretion_Homo sapiens_hsa049720.22840793
96Amphetamine addiction_Homo sapiens_hsa050310.19842128
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.19706932
98Glutamatergic synapse_Homo sapiens_hsa047240.19632812
99mTOR signaling pathway_Homo sapiens_hsa041500.18843431
100Estrogen signaling pathway_Homo sapiens_hsa049150.18152904
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16285289
102Fructose and mannose metabolism_Homo sapiens_hsa000510.15667156
103Insulin resistance_Homo sapiens_hsa049310.14233989
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.14021296
105Ovarian steroidogenesis_Homo sapiens_hsa049130.00445189
106Amoebiasis_Homo sapiens_hsa05146-0.2309663
107Bladder cancer_Homo sapiens_hsa05219-0.2202234
108Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2109665
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.2060930
110Mineral absorption_Homo sapiens_hsa04978-0.2033899
111Insulin signaling pathway_Homo sapiens_hsa04910-0.1857200
112Renin-angiotensin system_Homo sapiens_hsa04614-0.1833974
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1772312
114Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1761742
115African trypanosomiasis_Homo sapiens_hsa05143-0.1741169
116Protein digestion and absorption_Homo sapiens_hsa04974-0.1619543
117Hepatitis C_Homo sapiens_hsa05160-0.1318526
118Protein export_Homo sapiens_hsa03060-0.1229059
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0969936
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0895742
121Regulation of autophagy_Homo sapiens_hsa04140-0.0580984
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0456889
123AMPK signaling pathway_Homo sapiens_hsa04152-0.0451305
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0333414
125Glucagon signaling pathway_Homo sapiens_hsa04922-0.0328024
126Ether lipid metabolism_Homo sapiens_hsa00565-0.0288006
127Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0112828

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »