SHROOM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.92133014
2central nervous system myelination (GO:0022010)5.92133014
3neuron cell-cell adhesion (GO:0007158)5.24989890
4pyrimidine nucleobase catabolic process (GO:0006208)4.83610876
5presynaptic membrane assembly (GO:0097105)4.49981844
6presynaptic membrane organization (GO:0097090)4.28875003
7fatty acid elongation (GO:0030497)4.24474756
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.24160197
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.14834005
10synaptic vesicle exocytosis (GO:0016079)4.11195514
11synaptic vesicle maturation (GO:0016188)4.04889737
12vocalization behavior (GO:0071625)4.04223547
13myelination (GO:0042552)4.03757464
14axon ensheathment (GO:0008366)4.03649743
15ensheathment of neurons (GO:0007272)4.03649743
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.03358410
17neuronal action potential propagation (GO:0019227)3.93686412
18protein localization to synapse (GO:0035418)3.93676282
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.91557695
20regulation of synaptic vesicle exocytosis (GO:2000300)3.90619347
21negative regulation of neurotransmitter transport (GO:0051589)3.84324025
22negative regulation of neurotransmitter secretion (GO:0046929)3.83665292
23neuron recognition (GO:0008038)3.83465234
24locomotory exploration behavior (GO:0035641)3.80294354
25glutamate secretion (GO:0014047)3.79978342
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.79283677
27transmission of nerve impulse (GO:0019226)3.79142069
28long-chain fatty acid biosynthetic process (GO:0042759)3.77656340
29nucleobase catabolic process (GO:0046113)3.74131879
30dendritic spine morphogenesis (GO:0060997)3.73618903
31layer formation in cerebral cortex (GO:0021819)3.67357046
32gamma-aminobutyric acid transport (GO:0015812)3.62620421
33establishment of mitochondrion localization (GO:0051654)3.60315792
34regulation of glutamate receptor signaling pathway (GO:1900449)3.56844749
35neurotransmitter-gated ion channel clustering (GO:0072578)3.54075852
36glutamate receptor signaling pathway (GO:0007215)3.47751295
37neuron-neuron synaptic transmission (GO:0007270)3.45351528
38synaptic transmission, glutamatergic (GO:0035249)3.44617453
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.35638229
40regulation of dendritic spine morphogenesis (GO:0061001)3.34421114
41axonal fasciculation (GO:0007413)3.33670783
42regulation of synaptic vesicle transport (GO:1902803)3.25600283
43exploration behavior (GO:0035640)3.24452575
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24376434
45glycerophospholipid catabolic process (GO:0046475)3.22639965
46dendrite morphogenesis (GO:0048813)3.21587393
47adult walking behavior (GO:0007628)3.20759181
48negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.19578358
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19082227
50regulation of neuronal synaptic plasticity (GO:0048168)3.18827432
51neuronal ion channel clustering (GO:0045161)3.17188048
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14208550
53L-amino acid import (GO:0043092)3.14039959
54neurotransmitter secretion (GO:0007269)3.13469858
55cerebellar granule cell differentiation (GO:0021707)3.08168886
56postsynaptic membrane organization (GO:0001941)3.04534589
57axon extension (GO:0048675)3.04216696
58regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.03257650
59establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.02040296
60mitochondrion transport along microtubule (GO:0047497)3.02040296
61positive regulation of membrane potential (GO:0045838)3.01133081
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98201859
63regulation of excitatory postsynaptic membrane potential (GO:0060079)2.96536160
64cerebral cortex radially oriented cell migration (GO:0021799)2.95405056
65regulation of dendritic spine development (GO:0060998)2.93867962
66negative regulation of axonogenesis (GO:0050771)2.93465258
67substantia nigra development (GO:0021762)2.90079873
68long-term synaptic potentiation (GO:0060291)2.89997687
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88878583
70* apical protein localization (GO:0045176)2.87980799
71long-term memory (GO:0007616)2.87406574
72peptidyl-tyrosine autophosphorylation (GO:0038083)2.83692350
73regulation of postsynaptic membrane potential (GO:0060078)2.83682586
74sodium ion export (GO:0071436)2.82517396
75neurofilament cytoskeleton organization (GO:0060052)2.81553300
76neurotransmitter transport (GO:0006836)2.79985082
77startle response (GO:0001964)2.79456240
78dendrite development (GO:0016358)2.79436946
79positive regulation of synapse assembly (GO:0051965)2.77268026
80cell migration in hindbrain (GO:0021535)2.76899685
81central nervous system projection neuron axonogenesis (GO:0021952)2.75552971
82membrane hyperpolarization (GO:0060081)2.75053939
83nerve growth factor signaling pathway (GO:0038180)2.74342641
84neuron projection extension (GO:1990138)2.73877390
85regulation of synaptic transmission, glutamatergic (GO:0051966)2.73702353
86regulation of synaptic plasticity (GO:0048167)2.73568037
87oligodendrocyte differentiation (GO:0048709)2.72858803
88adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.72702585
89synapse assembly (GO:0007416)2.71777979
90synapse organization (GO:0050808)2.71280192
91positive regulation of dendritic spine development (GO:0060999)2.71152617
92regulation of synaptic transmission, GABAergic (GO:0032228)2.70317051
93amino acid import (GO:0043090)2.69988566
94behavioral response to cocaine (GO:0048148)2.69785940
95synaptic vesicle docking involved in exocytosis (GO:0016081)2.69256096
96regulation of synapse structural plasticity (GO:0051823)2.68903984
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68753624
98calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.68644372
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.67867445
100membrane assembly (GO:0071709)2.67312448
101dendritic spine organization (GO:0097061)2.65670844
102mating behavior (GO:0007617)2.65193241
103neuron remodeling (GO:0016322)2.65103273
104regulation of collateral sprouting (GO:0048670)2.64855661
105auditory behavior (GO:0031223)2.64733903
106positive regulation of synaptic transmission, GABAergic (GO:0032230)2.64286521
107synaptic vesicle endocytosis (GO:0048488)2.62525786
108regulation of neurotransmitter secretion (GO:0046928)2.62517156
109negative regulation of axon extension (GO:0030517)2.61525939
110* asymmetric protein localization (GO:0008105)2.60929498
111positive regulation of dendritic spine morphogenesis (GO:0061003)2.59645990
112learning (GO:0007612)2.58989160
113cell communication by electrical coupling (GO:0010644)2.55637058
114ephrin receptor signaling pathway (GO:0048013)2.52552914
115regulation of axon guidance (GO:1902667)2.50651106
116dopamine receptor signaling pathway (GO:0007212)2.48319328
117cerebellar Purkinje cell layer development (GO:0021680)2.47912609
118innervation (GO:0060384)2.47127822
119paraxial mesoderm development (GO:0048339)2.46194385
120mechanosensory behavior (GO:0007638)2.44636385
121developmental cell growth (GO:0048588)2.42729262
122regulation of axon extension involved in axon guidance (GO:0048841)2.42517115
123cellular potassium ion homeostasis (GO:0030007)2.40992585
124ganglion development (GO:0061548)2.34506930
125cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.34150172
126regulation of synapse assembly (GO:0051963)2.33425880
127cochlea development (GO:0090102)2.32637153
128axon extension involved in axon guidance (GO:0048846)2.32450104
129neuron projection extension involved in neuron projection guidance (GO:1902284)2.32450104
130response to auditory stimulus (GO:0010996)2.31604957
131short-term memory (GO:0007614)2.28657671
132retinal ganglion cell axon guidance (GO:0031290)2.28193783
133artery development (GO:0060840)2.26026119
134positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.23513821
135positive regulation of synapse maturation (GO:0090129)2.23395373
136spinal cord development (GO:0021510)2.20897156
137organelle transport along microtubule (GO:0072384)2.20561254
138cell communication involved in cardiac conduction (GO:0086065)2.20497235
139regulation of calcium ion-dependent exocytosis (GO:0017158)2.19459853
140axon cargo transport (GO:0008088)2.16765460
141neuron migration (GO:0001764)2.15984649
142behavioral response to nicotine (GO:0035095)2.15855203

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.37216420
2GBX2_23144817_ChIP-Seq_PC3_Human4.05560232
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80269564
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76989799
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69960020
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38365716
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38365716
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.38249831
9TAF15_26573619_Chip-Seq_HEK293_Human2.35364252
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28609323
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24990416
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24874947
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22733179
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19351258
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16956967
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.15398487
17REST_21632747_ChIP-Seq_MESCs_Mouse2.11630263
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10235666
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09217196
20AR_21572438_ChIP-Seq_LNCaP_Human1.99817694
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.99723976
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.96195689
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94235478
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94192140
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.93371679
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.91734022
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91700217
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87466404
29* DROSHA_22980978_ChIP-Seq_HELA_Human1.86839902
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84236426
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73280112
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73179771
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.69980191
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.68967089
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60228794
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59274346
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58872408
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.56626398
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55629480
40P300_19829295_ChIP-Seq_ESCs_Human1.55256562
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.54296518
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52875333
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.52032244
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.51760781
45FUS_26573619_Chip-Seq_HEK293_Human1.51745369
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.50444106
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49239368
48* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45355157
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44444023
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41985624
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41698047
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41238349
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36576611
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36181012
55STAT3_23295773_ChIP-Seq_U87_Human1.35672437
56VDR_22108803_ChIP-Seq_LS180_Human1.35636072
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34022181
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31721487
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30815914
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29570717
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28245363
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28148257
63ER_23166858_ChIP-Seq_MCF-7_Human1.27661383
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.27627930
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26956697
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26764842
67RNF2_27304074_Chip-Seq_NSC_Mouse1.26638811
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24247646
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23836662
70ISL1_27105846_Chip-Seq_CPCs_Mouse1.21893231
71* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21317526
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.19691176
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.18217528
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.17903278
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17554715
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17254646
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17196791
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16653494
79* TCF4_23295773_ChIP-Seq_U87_Human1.15902312
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.15744684
81ZNF274_21170338_ChIP-Seq_K562_Hela1.15221544
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15065267
83AHR_22903824_ChIP-Seq_MCF-7_Human1.15031342
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.14727947
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14480917
86IGF1R_20145208_ChIP-Seq_DFB_Human1.12674641
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12107908
88SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.11592703
89AR_25329375_ChIP-Seq_VCAP_Human1.10836294
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.10572233
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09997712
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08407810
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06802337
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05997350
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.04583937
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04457254
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04065463
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02662066
99* AR_19668381_ChIP-Seq_PC3_Human1.02348124
100TP53_16413492_ChIP-PET_HCT116_Human1.01947983
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.01233679
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01182136
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01069760
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00708261
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98428124
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97996343
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97480603
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97119855
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97119855
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95858491
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95858491
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95858491
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95818553
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95732522
115JUN_21703547_ChIP-Seq_K562_Human0.95422650
116KDM2B_26808549_Chip-Seq_K562_Human0.95373765
117EP300_21415370_ChIP-Seq_HL-1_Mouse0.95359430
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.94955895
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.94400698
120* ESR2_21235772_ChIP-Seq_MCF-7_Human0.93746220
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.93605735
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93185851
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92783137
124PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.92346689
125POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92058871
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91756553
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90414206
128SOX2_16153702_ChIP-ChIP_HESCs_Human0.90092295
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89659942
130CTCF_27219007_Chip-Seq_Bcells_Human0.89379098
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88373003
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87658139
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87658139
134TP53_18474530_ChIP-ChIP_U2OS_Human0.86943942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.05954858
2MP0004859_abnormal_synaptic_plasticity4.69719066
3MP0004270_analgesia3.89930810
4MP0003635_abnormal_synaptic_transmissio3.33999537
5MP0009745_abnormal_behavioral_response2.85261947
6MP0002064_seizures2.84681450
7MP0001486_abnormal_startle_reflex2.73468711
8MP0002063_abnormal_learning/memory/cond2.70013046
9MP0009046_muscle_twitch2.61479539
10MP0002272_abnormal_nervous_system2.59995595
11MP0000920_abnormal_myelination2.58628966
12MP0005423_abnormal_somatic_nervous2.49365893
13MP0002734_abnormal_mechanical_nocicepti2.44152597
14MP0000778_abnormal_nervous_system2.42303679
15MP0002572_abnormal_emotion/affect_behav2.38936555
16MP0001529_abnormal_vocalization2.33712531
17MP0003329_amyloid_beta_deposits2.25315094
18MP0004885_abnormal_endolymph2.23007141
19MP0000566_synostosis2.22321916
20MP0002822_catalepsy2.17625367
21MP0001968_abnormal_touch/_nociception2.08873758
22MP0001440_abnormal_grooming_behavior1.90120562
23MP0010030_abnormal_orbit_morphology1.79479846
24MP0003123_paternal_imprinting1.74854365
25MP0001905_abnormal_dopamine_level1.72680342
26MP0003121_genomic_imprinting1.72547326
27MP0004742_abnormal_vestibular_system1.72459650
28MP0009780_abnormal_chondrocyte_physiolo1.72146641
29MP0002067_abnormal_sensory_capabilities1.71419747
30MP0004142_abnormal_muscle_tone1.68346515
31MP0002733_abnormal_thermal_nociception1.66526117
32MP0005386_behavior/neurological_phenoty1.64383245
33MP0004924_abnormal_behavior1.64383245
34MP0000955_abnormal_spinal_cord1.64103260
35MP0001970_abnormal_pain_threshold1.62344825
36MP0002736_abnormal_nociception_after1.58666810
37MP0003690_abnormal_glial_cell1.57436705
38MP0003634_abnormal_glial_cell1.57103436
39MP0002882_abnormal_neuron_morphology1.56723936
40MP0001485_abnormal_pinna_reflex1.55414146
41MP0002735_abnormal_chemical_nociception1.53950158
42MP0002184_abnormal_innervation1.53802739
43MP0005551_abnormal_eye_electrophysiolog1.50029509
44MP0005171_absent_coat_pigmentation1.47983838
45MP0006292_abnormal_olfactory_placode1.45970470
46MP0002557_abnormal_social/conspecific_i1.45315680
47MP0000579_abnormal_nail_morphology1.43872612
48MP0002229_neurodegeneration1.43518804
49MP0002066_abnormal_motor_capabilities/c1.42830787
50MP0003950_abnormal_plasma_membrane1.41539242
51MP0003890_abnormal_embryonic-extraembry1.39705900
52MP0001501_abnormal_sleep_pattern1.38958787
53MP0003632_abnormal_nervous_system1.37952898
54MP0003315_abnormal_perineum_morphology1.35019559
55MP0005187_abnormal_penis_morphology1.34768988
56MP0004811_abnormal_neuron_physiology1.33361680
57MP0003283_abnormal_digestive_organ1.32964166
58MP0008569_lethality_at_weaning1.30576590
59MP0006276_abnormal_autonomic_nervous1.28805317
60MP0003119_abnormal_digestive_system1.27205408
61MP0000049_abnormal_middle_ear1.26105206
62MP0003787_abnormal_imprinting1.25885939
63MP0003631_nervous_system_phenotype1.24579249
64MP0000534_abnormal_ureter_morphology1.23256518
65MP0003136_yellow_coat_color1.22928281
66MP0005409_darkened_coat_color1.22741891
67MP0008789_abnormal_olfactory_epithelium1.22740410
68MP0002152_abnormal_brain_morphology1.21427867
69MP0003941_abnormal_skin_development1.17861739
70MP0003633_abnormal_nervous_system1.17537730
71MP0003942_abnormal_urinary_system1.17410979
72MP0001963_abnormal_hearing_physiology1.14760879
73MP0003122_maternal_imprinting1.12441670
74MP0002752_abnormal_somatic_nervous1.11943780
75MP0001984_abnormal_olfaction1.11607133
76MP0001188_hyperpigmentation1.10940639
77MP0003937_abnormal_limbs/digits/tail_de1.10273221
78MP0008877_abnormal_DNA_methylation1.09505547
79MP0005646_abnormal_pituitary_gland1.09451002
80MP0004043_abnormal_pH_regulation1.08413961
81MP0002233_abnormal_nose_morphology1.06235352
82MP0002697_abnormal_eye_size1.04899040
83MP0005645_abnormal_hypothalamus_physiol1.02093186
84MP0010368_abnormal_lymphatic_system1.01983739
85MP0001502_abnormal_circadian_rhythm0.99798226
86MP0000462_abnormal_digestive_system0.99520907
87MP0002234_abnormal_pharynx_morphology0.98852863
88MP0004858_abnormal_nervous_system0.97051508
89MP0006072_abnormal_retinal_apoptosis0.96998288
90MP0000604_amyloidosis0.95837928
91MP0001177_atelectasis0.95650976
92MP0003755_abnormal_palate_morphology0.95516699
93MP0005623_abnormal_meninges_morphology0.93507932
94MP0003385_abnormal_body_wall0.90870100
95MP0000631_abnormal_neuroendocrine_gland0.90759996
96MP0001293_anophthalmia0.89773333
97MP0005248_abnormal_Harderian_gland0.88678389
98MP0009672_abnormal_birth_weight0.88645712
99MP0003879_abnormal_hair_cell0.88503295
100MP0002249_abnormal_larynx_morphology0.88310130
101MP0002081_perinatal_lethality0.84370475
102MP0003935_abnormal_craniofacial_develop0.84063793
103MP0003861_abnormal_nervous_system0.83618129
104MP0001299_abnormal_eye_distance/0.81403805
105MP0005195_abnormal_posterior_eye0.81358159
106MP0004145_abnormal_muscle_electrophysio0.79720676
107MP0002116_abnormal_craniofacial_bone0.79325830
108MP0000026_abnormal_inner_ear0.78744811
109MP0002751_abnormal_autonomic_nervous0.78455834
110MP0002090_abnormal_vision0.78399154
111MP0004133_heterotaxia0.77842808
112MP0002938_white_spotting0.77658510
113MP0002069_abnormal_eating/drinking_beha0.76298700
114MP0000762_abnormal_tongue_morphology0.76060454
115MP0001286_abnormal_eye_development0.72777725
116MP0005253_abnormal_eye_physiology0.72639904
117MP0004085_abnormal_heartbeat0.71344879
118MP0009053_abnormal_anal_canal0.70661392
119MP0003938_abnormal_ear_development0.69840548
120MP0005410_abnormal_fertilization0.65238812
121MP0010678_abnormal_skin_adnexa0.65233966
122MP0000537_abnormal_urethra_morphology0.65049207
123MP0001943_abnormal_respiration0.62773212
124MP0000751_myopathy0.61457969
125MP0002909_abnormal_adrenal_gland0.60339771
126MP0005499_abnormal_olfactory_system0.59484933
127MP0005394_taste/olfaction_phenotype0.59484933
128MP0003137_abnormal_impulse_conducting0.57252252
129MP0000013_abnormal_adipose_tissue0.56894953
130MP0008874_decreased_physiological_sensi0.56659466
131MP0001664_abnormal_digestion0.55420001
132MP0002082_postnatal_lethality0.54834149
133MP0010770_preweaning_lethality0.54834149
134MP0002653_abnormal_ependyma_morphology0.54611567
135MP0004272_abnormal_basement_membrane0.53921550
136MP0010769_abnormal_survival0.53145184

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.18195988
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.78618884
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.78618884
4Myokymia (HP:0002411)4.78043530
5Neurofibrillary tangles (HP:0002185)4.74685534
6Abnormality of the corticospinal tract (HP:0002492)4.34021667
7Insidious onset (HP:0003587)4.15414311
8Termporal pattern (HP:0011008)4.15414311
9Cerebral inclusion bodies (HP:0100314)4.05377056
10Atonic seizures (HP:0010819)3.98297680
11Epileptic encephalopathy (HP:0200134)3.90996756
12Focal seizures (HP:0007359)3.78363372
13Supranuclear gaze palsy (HP:0000605)3.61573317
14Sensory axonal neuropathy (HP:0003390)3.28926230
15Dysmetria (HP:0001310)3.28516014
16Spastic gait (HP:0002064)3.26524988
17Hyperventilation (HP:0002883)3.23349535
18Ankle clonus (HP:0011448)3.13454686
19Akinesia (HP:0002304)3.02347049
20Action tremor (HP:0002345)3.01054724
21Intention tremor (HP:0002080)2.97884166
22Peripheral hypomyelination (HP:0007182)2.92651359
23Broad-based gait (HP:0002136)2.87694176
24Absence seizures (HP:0002121)2.83020849
25Dialeptic seizures (HP:0011146)2.81374335
26Scanning speech (HP:0002168)2.78243494
27Progressive cerebellar ataxia (HP:0002073)2.73995302
28Dysdiadochokinesis (HP:0002075)2.64416860
29Generalized tonic-clonic seizures (HP:0002069)2.60258086
30Limb dystonia (HP:0002451)2.57774056
31Visual hallucinations (HP:0002367)2.55348906
32Thickened helices (HP:0000391)2.54579796
33Drooling (HP:0002307)2.52669835
34Excessive salivation (HP:0003781)2.52669835
35Urinary bladder sphincter dysfunction (HP:0002839)2.50539502
36Onion bulb formation (HP:0003383)2.49576183
37Cortical dysplasia (HP:0002539)2.47691057
38Lower limb muscle weakness (HP:0007340)2.43367572
39Urinary urgency (HP:0000012)2.40301487
40Gaze-evoked nystagmus (HP:0000640)2.39924194
41Impaired vibration sensation in the lower limbs (HP:0002166)2.36213796
42Febrile seizures (HP:0002373)2.34933086
43Generalized myoclonic seizures (HP:0002123)2.33816818
44Megalencephaly (HP:0001355)2.33442168
45Cerebral hypomyelination (HP:0006808)2.31922221
46Hepatoblastoma (HP:0002884)2.30865110
47Mutism (HP:0002300)2.30759000
48Parakeratosis (HP:0001036)2.27461987
49Abnormal auditory evoked potentials (HP:0006958)2.27081377
50Epileptiform EEG discharges (HP:0011182)2.26640858
51Hemiparesis (HP:0001269)2.25366196
52Pheochromocytoma (HP:0002666)2.23545448
53Morphological abnormality of the pyramidal tract (HP:0002062)2.22391838
54Sleep apnea (HP:0010535)2.21627931
55EEG with generalized epileptiform discharges (HP:0011198)2.19230914
56Absent speech (HP:0001344)2.15434496
57Progressive inability to walk (HP:0002505)2.15208457
58Alacrima (HP:0000522)2.15096537
59Increased serum pyruvate (HP:0003542)2.14266678
60Abnormality of glycolysis (HP:0004366)2.14266678
61Clonus (HP:0002169)2.12702361
62Hypsarrhythmia (HP:0002521)2.12053160
63Amblyopia (HP:0000646)2.12008582
64Cutaneous finger syndactyly (HP:0010554)2.11573395
65Abnormal eating behavior (HP:0100738)2.11054330
66Truncal ataxia (HP:0002078)2.10612594
67Blue irides (HP:0000635)2.09509474
68Anxiety (HP:0000739)2.09504919
69Retinal dysplasia (HP:0007973)2.08635177
70Generalized hypotonia (HP:0001290)2.07934557
71Torticollis (HP:0000473)2.05103892
72Shawl scrotum (HP:0000049)2.04134374
73Poor eye contact (HP:0000817)2.03500914
74Abnormality of binocular vision (HP:0011514)2.03298903
75Diplopia (HP:0000651)2.03298903
76Postural instability (HP:0002172)2.02589168
77High anterior hairline (HP:0009890)2.01418702
78Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.96938072
79Choanal stenosis (HP:0000452)1.96436613
80Bronchomalacia (HP:0002780)1.96428087
81Myelomeningocele (HP:0002475)1.95831709
82Impaired social interactions (HP:0000735)1.94999995
83Abnormal social behavior (HP:0012433)1.94999995
84Cutaneous syndactyly (HP:0012725)1.93428957
85Partial duplication of thumb phalanx (HP:0009944)1.90973610
86Ulnar claw (HP:0001178)1.90846194
87Gait imbalance (HP:0002141)1.90413851
88Depression (HP:0000716)1.90361002
89Increased circulating renin level (HP:0000848)1.89936811
90Leukodystrophy (HP:0002415)1.89743917
91Aplasia involving bones of the upper limbs (HP:0009823)1.89453259
92Aplasia of the phalanges of the hand (HP:0009802)1.89453259
93Aplasia involving bones of the extremities (HP:0009825)1.89453259
94Specific learning disability (HP:0001328)1.89085562
95Labial hypoplasia (HP:0000066)1.88713833
96Turricephaly (HP:0000262)1.86460642
97Fetal akinesia sequence (HP:0001989)1.83983896
98Clumsiness (HP:0002312)1.82471546
99Obstructive sleep apnea (HP:0002870)1.81843368
100Poor suck (HP:0002033)1.81294570
101Focal dystonia (HP:0004373)1.80511271
102Hypoplasia of the brainstem (HP:0002365)1.80423340
103Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80423340
104Septo-optic dysplasia (HP:0100842)1.79826899
105Hammertoe (HP:0001765)1.79725260
106Bowel incontinence (HP:0002607)1.79592336
107Abnormality of salivation (HP:0100755)1.78509619
108Midline defect of the nose (HP:0004122)1.78469453
109Vaginal atresia (HP:0000148)1.78436394
110Neuroendocrine neoplasm (HP:0100634)1.77918006
111Abdominal situs inversus (HP:0003363)1.77638231
112Abnormality of abdominal situs (HP:0011620)1.77638231
113Polyphagia (HP:0002591)1.76162650
114Genital tract atresia (HP:0001827)1.75663245
115Hypoplastic female external genitalia (HP:0012815)1.74533320
116Anteriorly placed anus (HP:0001545)1.72409957
117Abnormality of the labia minora (HP:0012880)1.71350484
118Neuronal loss in central nervous system (HP:0002529)1.70178328
119Widely spaced teeth (HP:0000687)1.69219478
120Osteomalacia (HP:0002749)1.69106673
121Delusions (HP:0000746)1.69100203
122Shallow orbits (HP:0000586)1.68923811
123Lissencephaly (HP:0001339)1.68919160
124Craniofacial dystonia (HP:0012179)1.68865199
125Bifid tongue (HP:0010297)1.68237581
126Partial agenesis of the corpus callosum (HP:0001338)1.67658895
127Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.67497795
128Inability to walk (HP:0002540)1.67250174
129Abnormality of the aortic arch (HP:0012303)1.64416235
130Micropenis (HP:0000054)1.64279343
131Anophthalmia (HP:0000528)1.64010406
132Scrotal hypoplasia (HP:0000046)1.61458332
133Abnormality of the lower motor neuron (HP:0002366)1.60912407
134Optic nerve hypoplasia (HP:0000609)1.60579981
135Renal hypoplasia (HP:0000089)1.59745632
136Absent eyebrow (HP:0002223)1.59323034
137Partial duplication of the phalanx of hand (HP:0009999)1.58956086
138Hand muscle atrophy (HP:0009130)1.58448851
139Flat acetabular roof (HP:0003180)1.58406023
140Morphological abnormality of the middle ear (HP:0008609)1.57429120
141Broad metatarsal (HP:0001783)1.53350485
142Absent septum pellucidum (HP:0001331)1.51631106
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.51391402
144Anterior segment dysgenesis (HP:0007700)1.50421665
145Split foot (HP:0001839)1.50219110
146Failure to thrive in infancy (HP:0001531)1.49466662
147Enlarged penis (HP:0000040)1.49400781
148Oligodactyly (hands) (HP:0001180)1.49117726
149Hypoventilation (HP:0002791)1.47235368
150Spinal cord compression (HP:0002176)1.46227438
151Absent eyelashes (HP:0000561)1.43680785
152Abnormality of the phalanges of the hallux (HP:0010057)1.43634810
153Pachygyria (HP:0001302)1.42985813
154Spastic tetraplegia (HP:0002510)1.40195470
155Bilateral microphthalmos (HP:0007633)1.40052942
156Intellectual disability, moderate (HP:0002342)1.39353983

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.58431436
2STK393.57577277
3EPHA43.47081000
4OXSR12.82968923
5NTRK32.66415162
6MAP3K92.61679405
7CASK2.59312874
8BCR2.27421589
9MAP3K42.20544725
10CAMK1D2.16216165
11PRPF4B2.15709797
12PAK62.09609851
13PNCK2.00725241
14TNIK1.87877020
15NTRK21.83617186
16NTRK11.83563221
17EPHB21.77343470
18MINK11.73888935
19KSR21.73490633
20UHMK11.73415189
21MAP2K71.65292033
22PKN11.63000559
23CDK191.57956757
24WNK41.56992393
25FGFR21.48679792
26DAPK21.42527095
27TYRO31.40921201
28CSNK1G21.40555001
29CDK51.37664796
30KSR11.37217607
31CSNK1G31.34905421
32MAPK131.33163594
33CAMK2B1.31958010
34TIE11.29343616
35CSNK1A1L1.26910862
36TSSK61.22620454
37PLK21.20631657
38TAOK11.19463957
39MAP2K41.17790971
40PAK31.16721355
41PHKG21.15919335
42PHKG11.15919335
43EPHA21.14284287
44ICK1.12285621
45SGK4941.11874254
46SGK2231.11874254
47CAMK2A1.11650763
48LMTK21.07975609
49WNK11.07250249
50NEK61.06136322
51CDK141.04749322
52LIMK11.01680101
53MET1.01034804
54MAP3K21.00524654
55CSNK1G10.99831863
56FGR0.99538419
57PRKD30.98799936
58EPHB10.98124817
59DYRK20.95860554
60CDK150.95753474
61TRIM280.95573326
62CDK180.95417710
63ARAF0.91934076
64ROCK20.91063025
65ERBB40.91024602
66WNK30.90665570
67MARK20.89668370
68LATS20.88730303
69CAMK2D0.86119730
70GRK50.85670502
71PRKCG0.83944046
72TESK10.83394875
73PBK0.82209477
74CDK11A0.82102087
75PTK20.81455730
76PRKCE0.75657323
77FES0.70221600
78STK110.68980804
79PKN20.68978274
80CAMK2G0.68973857
81MAPKAPK50.68449554
82DYRK1A0.67618306
83RPS6KA20.67215887
84PTK2B0.65429883
85DMPK0.65216318
86SGK20.64456709
87AKT30.62615936
88PRKCI0.61166802
89MAP3K120.59846272
90DYRK30.58886799
91MTOR0.57471724
92MAP3K130.57236639
93CAMK10.53676982
94PDPK10.52734549
95BRAF0.51055350
96DAPK10.51049322
97FYN0.50494972
98PDGFRA0.50255514
99RET0.49966293
100AURKA0.49500936
101BMPR1B0.49271773
102SGK10.49018073
103PRKCZ0.48209811
104CAMKK10.47753972
105BMPR20.47516648
106TRIB30.46162805
107SIK20.45763286
108NME10.44318351
109EEF2K0.44038299
110BRD40.43848611
111RAF10.42879004
112CSNK1D0.42403210
113MAPK100.41618757
114PRKCH0.41189415
115SIK10.40730377
116RIPK10.39418282
117PAK20.39255833
118STK380.38342282
119CDK120.38319152
120FER0.37707676
121PRKACB0.37661864
122PRKD20.37527522
123PRKG10.37255977
124PRKAA10.37140734
125RPS6KA30.36900425
126CAMK1G0.36820465
127SGK30.36670865
128CSNK1E0.36446324
129STK38L0.34855800
130ERBB20.34166045
131PRKCQ0.32817370
132CSNK1A10.32661555
133PRKACA0.32026417
134ROCK10.31166122

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.21685226
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.69171567
3GABAergic synapse_Homo sapiens_hsa047272.62696543
4Synaptic vesicle cycle_Homo sapiens_hsa047212.59983492
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45775866
6Glutamatergic synapse_Homo sapiens_hsa047242.37814904
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37160229
8Morphine addiction_Homo sapiens_hsa050322.18824000
9Circadian entrainment_Homo sapiens_hsa047132.11346991
10Axon guidance_Homo sapiens_hsa043601.95296410
11Long-term potentiation_Homo sapiens_hsa047201.94717548
12Steroid biosynthesis_Homo sapiens_hsa001001.93095566
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84229090
14Serotonergic synapse_Homo sapiens_hsa047261.82002019
15Dopaminergic synapse_Homo sapiens_hsa047281.80593718
16Amphetamine addiction_Homo sapiens_hsa050311.76741621
17Long-term depression_Homo sapiens_hsa047301.74796213
18Olfactory transduction_Homo sapiens_hsa047401.72889009
19Collecting duct acid secretion_Homo sapiens_hsa049661.65796966
20Salivary secretion_Homo sapiens_hsa049701.65122797
21Fatty acid elongation_Homo sapiens_hsa000621.63696736
22Cholinergic synapse_Homo sapiens_hsa047251.57201498
23Basal cell carcinoma_Homo sapiens_hsa052171.50535747
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46048558
25Cocaine addiction_Homo sapiens_hsa050301.42853912
26Nitrogen metabolism_Homo sapiens_hsa009101.41949128
27Ether lipid metabolism_Homo sapiens_hsa005651.40492206
28Butanoate metabolism_Homo sapiens_hsa006501.38634613
29Gastric acid secretion_Homo sapiens_hsa049711.34532359
30Renin secretion_Homo sapiens_hsa049241.34521649
31Taste transduction_Homo sapiens_hsa047421.33286757
32Insulin secretion_Homo sapiens_hsa049111.32765754
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32254896
34Gap junction_Homo sapiens_hsa045401.29281140
35Phototransduction_Homo sapiens_hsa047441.25625343
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22109124
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19594277
38Vibrio cholerae infection_Homo sapiens_hsa051101.19518968
39Oxytocin signaling pathway_Homo sapiens_hsa049211.17289620
40Fatty acid biosynthesis_Homo sapiens_hsa000611.16043088
41Oxidative phosphorylation_Homo sapiens_hsa001901.15643710
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13100556
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04698046
44Calcium signaling pathway_Homo sapiens_hsa040201.04626169
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04421892
46Cardiac muscle contraction_Homo sapiens_hsa042601.01785410
47Adherens junction_Homo sapiens_hsa045201.01530345
48GnRH signaling pathway_Homo sapiens_hsa049121.01406719
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01312979
50ErbB signaling pathway_Homo sapiens_hsa040121.00779641
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99821705
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97068513
53Renal cell carcinoma_Homo sapiens_hsa052110.94202802
54Dorso-ventral axis formation_Homo sapiens_hsa043200.94112274
55cAMP signaling pathway_Homo sapiens_hsa040240.93575314
56Alzheimers disease_Homo sapiens_hsa050100.93444508
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91427291
58Melanogenesis_Homo sapiens_hsa049160.88123469
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87129781
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.87122129
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86080593
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81778934
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.80086635
64Ras signaling pathway_Homo sapiens_hsa040140.79812058
65Sulfur metabolism_Homo sapiens_hsa009200.79708161
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78264871
67Estrogen signaling pathway_Homo sapiens_hsa049150.78150588
68* Tight junction_Homo sapiens_hsa045300.77721360
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75708287
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75649761
71Endometrial cancer_Homo sapiens_hsa052130.74662188
72Choline metabolism in cancer_Homo sapiens_hsa052310.73346392
73Parkinsons disease_Homo sapiens_hsa050120.69711974
74Vitamin B6 metabolism_Homo sapiens_hsa007500.69099519
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68497068
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66567930
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65362455
78Ovarian steroidogenesis_Homo sapiens_hsa049130.64845407
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64447545
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64114126
81Pancreatic secretion_Homo sapiens_hsa049720.63684889
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63192010
83Glioma_Homo sapiens_hsa052140.62746051
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.61018432
85Notch signaling pathway_Homo sapiens_hsa043300.60385320
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58811610
87AMPK signaling pathway_Homo sapiens_hsa041520.57597304
88Bile secretion_Homo sapiens_hsa049760.57568797
89Oocyte meiosis_Homo sapiens_hsa041140.56947332
90ECM-receptor interaction_Homo sapiens_hsa045120.56586065
91Type II diabetes mellitus_Homo sapiens_hsa049300.56487754
92Glucagon signaling pathway_Homo sapiens_hsa049220.56264958
93MAPK signaling pathway_Homo sapiens_hsa040100.52586969
94Sphingolipid metabolism_Homo sapiens_hsa006000.51815800
95Rap1 signaling pathway_Homo sapiens_hsa040150.51452064
96Wnt signaling pathway_Homo sapiens_hsa043100.50494405
97TGF-beta signaling pathway_Homo sapiens_hsa043500.50477265
98Prion diseases_Homo sapiens_hsa050200.50140074
99Endocytosis_Homo sapiens_hsa041440.49731916
100Thyroid hormone synthesis_Homo sapiens_hsa049180.48991655
101mRNA surveillance pathway_Homo sapiens_hsa030150.48506798
102Alcoholism_Homo sapiens_hsa050340.48321587
103Hedgehog signaling pathway_Homo sapiens_hsa043400.47366776
104Fatty acid metabolism_Homo sapiens_hsa012120.47051237
105Dilated cardiomyopathy_Homo sapiens_hsa054140.46708545
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45219539
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45056158
108Circadian rhythm_Homo sapiens_hsa047100.45042839
109Arginine and proline metabolism_Homo sapiens_hsa003300.44560020
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43117624
111Lysine degradation_Homo sapiens_hsa003100.42149887
112Insulin signaling pathway_Homo sapiens_hsa049100.41174677
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.40147844
114Colorectal cancer_Homo sapiens_hsa052100.39876685
115Huntingtons disease_Homo sapiens_hsa050160.39525863
116Arginine biosynthesis_Homo sapiens_hsa002200.34375608
117Hippo signaling pathway_Homo sapiens_hsa043900.33318989
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30783673
119VEGF signaling pathway_Homo sapiens_hsa043700.30197690
120Linoleic acid metabolism_Homo sapiens_hsa005910.29787069
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29183547
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28382521
123Histidine metabolism_Homo sapiens_hsa003400.26220670
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26202260

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