SHROOM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the APX/Shroom family, which contain an N-terminal PDZ domain and a C-terminal ASD2 motif. The encoded protein may play a role in cytoskeletal architecture. Mutations in this gene have been linked to Stocco dos Santos X-linked mental retardation syndrome. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)5.35665083
2vascular endothelial growth factor signaling pathway (GO:0038084)5.33445517
3renal filtration (GO:0097205)4.68636085
4glomerular filtration (GO:0003094)4.50661058
5retina vasculature morphogenesis in camera-type eye (GO:0061299)4.35546116
6endothelium development (GO:0003158)4.29793448
7paraxial mesoderm development (GO:0048339)4.27055352
8lymphangiogenesis (GO:0001946)4.15871870
9hippo signaling (GO:0035329)4.15295110
10cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.93238471
11cell migration involved in sprouting angiogenesis (GO:0002042)3.90953329
12blood vessel maturation (GO:0001955)3.90846340
13regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.85570499
14surfactant homeostasis (GO:0043129)3.78500808
15neuron projection extension involved in neuron projection guidance (GO:1902284)3.74842930
16axon extension involved in axon guidance (GO:0048846)3.74842930
17endothelial cell morphogenesis (GO:0001886)3.73832300
18basement membrane organization (GO:0071711)3.60484818
19plasma membrane repair (GO:0001778)3.57260335
20regulation of endothelial cell differentiation (GO:0045601)3.50683100
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46530944
22vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.43376231
23blood vessel endothelial cell migration (GO:0043534)3.42656708
24patterning of blood vessels (GO:0001569)3.40652612
25artery development (GO:0060840)3.39733153
26positive regulation of vasculogenesis (GO:2001214)3.35371166
27cardiac myofibril assembly (GO:0055003)3.35071928
28glomerular basement membrane development (GO:0032836)3.34100488
29chondrocyte proliferation (GO:0035988)3.31663762
30vasculogenesis (GO:0001570)3.31327702
31coronary vasculature morphogenesis (GO:0060977)3.27863753
32axon ensheathment in central nervous system (GO:0032291)3.27413503
33central nervous system myelination (GO:0022010)3.27413503
34fibroblast migration (GO:0010761)3.26376689
35mesodermal cell differentiation (GO:0048333)3.23818173
36regulation of hippo signaling (GO:0035330)3.22466717
37negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.19230139
38regulation of sarcomere organization (GO:0060297)3.18955254
39dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.15287972
40sprouting angiogenesis (GO:0002040)3.14021351
41negative regulation of vascular permeability (GO:0043116)3.06152216
42cell adhesion mediated by integrin (GO:0033627)3.04958112
43ovulation from ovarian follicle (GO:0001542)3.02091794
44regulation of vasculogenesis (GO:2001212)3.01083533
45regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.01004055
46embryonic heart tube development (GO:0035050)3.00732071
47chemical homeostasis within a tissue (GO:0048875)2.97368190
48substrate-dependent cell migration (GO:0006929)2.97096579
49insulin-like growth factor receptor signaling pathway (GO:0048009)2.95909095
50metanephric nephron epithelium development (GO:0072243)2.92839104
51morphogenesis of an endothelium (GO:0003159)2.91081486
52endothelial tube morphogenesis (GO:0061154)2.91081486
53L-fucose catabolic process (GO:0042355)2.90362407
54fucose catabolic process (GO:0019317)2.90362407
55L-fucose metabolic process (GO:0042354)2.90362407
56negative regulation of synaptic transmission, GABAergic (GO:0032229)2.90266371
57heart trabecula formation (GO:0060347)2.89292151
58branching involved in salivary gland morphogenesis (GO:0060445)2.88635790
59wound healing, spreading of epidermal cells (GO:0035313)2.87527616
60regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.85605848
61vocalization behavior (GO:0071625)2.85127567
62metanephric epithelium development (GO:0072207)2.83177055
63behavioral response to nicotine (GO:0035095)2.82969182
64epithelial cell-cell adhesion (GO:0090136)2.82270244
65sarcomere organization (GO:0045214)2.81368043
66radial glial cell differentiation (GO:0060019)2.81202721
67heart morphogenesis (GO:0003007)2.80897686
68Notch signaling involved in heart development (GO:0061314)2.79381350
69notochord development (GO:0030903)2.79260689
70hemidesmosome assembly (GO:0031581)2.77346785
71regulation of tight junction assembly (GO:2000810)2.76133201
72dendritic spine morphogenesis (GO:0060997)2.75495365
73positive regulation of action potential (GO:0045760)2.75067802
74regulation of cardioblast differentiation (GO:0051890)2.73539697
75postsynaptic membrane organization (GO:0001941)2.72747720
76cell-substrate junction assembly (GO:0007044)2.69921317
77cell surface receptor signaling pathway involved in heart development (GO:0061311)2.69851417
78bundle of His cell to Purkinje myocyte communication (GO:0086069)2.69616982
79presynaptic membrane organization (GO:0097090)2.68829877
80regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.67600348
81embryonic foregut morphogenesis (GO:0048617)2.65752489
82presynaptic membrane assembly (GO:0097105)2.64157135
83venous blood vessel morphogenesis (GO:0048845)2.63998877
84negative regulation of protein localization to cell surface (GO:2000009)2.63698559
85mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.61253670
86myofibril assembly (GO:0030239)2.59826690
87blood vessel morphogenesis (GO:0048514)2.59673708
88adherens junction assembly (GO:0034333)2.59025220
89endocardial cushion development (GO:0003197)2.58580471
90regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58570982
91metanephric tubule development (GO:0072170)2.58545861
92metanephric nephron tubule development (GO:0072234)2.58545861
93negative regulation of cell fate specification (GO:0009996)2.54909384
94smooth muscle tissue development (GO:0048745)2.53987845
95ganglion development (GO:0061548)2.53457702
96polarized epithelial cell differentiation (GO:0030859)2.53112383
97substrate adhesion-dependent cell spreading (GO:0034446)2.52463513
98regulation of vascular permeability (GO:0043114)2.52339672
99limb development (GO:0060173)2.52126415
100appendage development (GO:0048736)2.52126415
101regulation of heart morphogenesis (GO:2000826)2.51885410
102growth hormone receptor signaling pathway (GO:0060396)2.50247851
103negative regulation of Rho protein signal transduction (GO:0035024)2.50042385
104regulation of SMAD protein import into nucleus (GO:0060390)2.50038644
105positive regulation of endothelial cell migration (GO:0010595)2.49476215
106cell migration involved in heart development (GO:0060973)2.48906907
107positive regulation of endothelial cell apoptotic process (GO:2000353)2.48619236
108positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.47381077
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.47271445
110nephron epithelium development (GO:0072009)2.47072250
111positive regulation of epithelial to mesenchymal transition (GO:0010718)2.46560970
112negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46487862
113blood vessel remodeling (GO:0001974)2.44818402
114interkinetic nuclear migration (GO:0022027)2.44735638
115cartilage morphogenesis (GO:0060536)2.44605147
116mesenchyme development (GO:0060485)2.44108968
117organ formation (GO:0048645)2.43780933
118membrane depolarization during action potential (GO:0086010)2.42329791
119positive regulation of blood vessel endothelial cell migration (GO:0043536)2.41615132
120endothelial cell migration (GO:0043542)2.41559625
121positive regulation of hormone biosynthetic process (GO:0046886)2.40917918
122positive regulation of endothelial cell differentiation (GO:0045603)2.40882571
123morphogenesis of an epithelial sheet (GO:0002011)2.40289995
124peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.40248027
125thyroid hormone metabolic process (GO:0042403)2.37302086
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.36163569
127regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.31031010
128cyclic nucleotide catabolic process (GO:0009214)2.30563804
129gamma-aminobutyric acid transport (GO:0015812)2.30004217
130positive regulation of sodium ion transmembrane transport (GO:1902307)2.29668032
131regulation of lipoprotein metabolic process (GO:0050746)2.29443458
132neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.29133156
133regulation of synapse maturation (GO:0090128)2.28768271
134parturition (GO:0007567)2.26968731
135negative regulation of systemic arterial blood pressure (GO:0003085)2.24317510
136inner ear receptor stereocilium organization (GO:0060122)2.23710258
137renal tubule morphogenesis (GO:0061333)2.21925770
138positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.20246709
139auditory behavior (GO:0031223)2.19750196
140cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.19674354
141positive regulation of protein kinase C signaling (GO:0090037)2.18492963
142cAMP catabolic process (GO:0006198)2.16526011
143regulation of axon extension involved in axon guidance (GO:0048841)2.16489909
144thyroid hormone generation (GO:0006590)2.16129291
145regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.15952935
146transmission of nerve impulse (GO:0019226)2.15238620
147startle response (GO:0001964)2.14864487
148epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.14593443
149regulation of action potential (GO:0098900)2.14079071
150negative chemotaxis (GO:0050919)2.13780557
151one-carbon compound transport (GO:0019755)2.12870747
152endothelial cell differentiation (GO:0045446)2.11413216
153glomerulus development (GO:0032835)2.11410452
154negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.11099937
155nephron tubule morphogenesis (GO:0072078)2.10601609
156nephron epithelium morphogenesis (GO:0072088)2.10601609
157reflex (GO:0060004)2.09569056
158negative regulation of endothelial cell migration (GO:0010596)2.08118789
159regulation of axon guidance (GO:1902667)2.07865063
160auditory receptor cell stereocilium organization (GO:0060088)2.07860005
161regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.07545274
162regulation of pigment cell differentiation (GO:0050932)2.07216347
163nucleus localization (GO:0051647)2.06123095
164negative regulation of blood vessel endothelial cell migration (GO:0043537)2.04857508
165nephron tubule development (GO:0072080)2.03532185
166positive regulation of cardiac muscle cell differentiation (GO:2000727)2.03375530
167detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.02769148
168tyrosine phosphorylation of STAT protein (GO:0007260)2.00256089
169negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.00118683
170negative regulation of translation, ncRNA-mediated (GO:0040033)2.00118683
171regulation of translation, ncRNA-mediated (GO:0045974)2.00118683
172atrial cardiac muscle cell action potential (GO:0086014)1.98622855
173regulation of establishment or maintenance of cell polarity (GO:0032878)1.98281326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.57618967
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.81083865
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.60721765
4EP300_21415370_ChIP-Seq_HL-1_Mouse2.93714568
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.86738870
6GBX2_23144817_ChIP-Seq_PC3_Human2.76905456
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.72567271
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.64082947
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59536672
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44038907
11GATA2_21666600_ChIP-Seq_HMVEC_Human2.41593309
12CLOCK_20551151_ChIP-Seq_293T_Human2.39356186
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.29247695
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.28747811
15VDR_22108803_ChIP-Seq_LS180_Human2.21227277
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15560810
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.15425674
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.14657303
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10802992
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.10769544
21CJUN_26792858_Chip-Seq_BT549_Human2.06115932
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05908758
23DROSHA_22980978_ChIP-Seq_HELA_Human2.01601008
24HIF1A_21447827_ChIP-Seq_MCF-7_Human2.00379994
25SALL4_18804426_ChIP-ChIP_XEN_Mouse1.98884185
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.97276799
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95530739
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.93870102
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92183079
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.91787659
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90637280
32ZNF274_21170338_ChIP-Seq_K562_Hela1.84788246
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.84640311
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.82891826
35TBX20_22080862_ChIP-Seq_HEART_Mouse1.82891826
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81947394
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.81291299
38BRD4_25478319_ChIP-Seq_HGPS_Human1.78884272
39TCF4_18268006_ChIP-ChIP_LS174T_Human1.76192102
40ISL1_27105846_Chip-Seq_CPCs_Mouse1.72922892
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.72901586
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71770501
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69584397
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69584397
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68717966
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.68024593
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66619043
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.66222108
49* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66027281
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65911904
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.64180578
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63238797
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62697259
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62697259
55* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61888432
56AR_21909140_ChIP-Seq_LNCAP_Human1.61356491
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60664129
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60532726
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60098695
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.58590278
61SMAD4_21799915_ChIP-Seq_A2780_Human1.58292004
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58272148
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.58071712
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.57968987
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.56033329
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.55745476
67P300_19829295_ChIP-Seq_ESCs_Human1.55297610
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54838428
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53895777
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52909111
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.52545743
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51542166
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50169384
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49535148
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49222690
76AR_21572438_ChIP-Seq_LNCaP_Human1.49044343
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48944532
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48715562
79TP53_16413492_ChIP-PET_HCT116_Human1.48524017
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46850545
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.46705284
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45843017
83AHR_22903824_ChIP-Seq_MCF-7_Human1.45750929
84STAT3_23295773_ChIP-Seq_U87_Human1.42985518
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40336675
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.39542342
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38882866
88MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.38840149
89FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.38734564
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37799901
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35675503
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35184095
93TCF4_23295773_ChIP-Seq_U87_Human1.34062316
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.33933746
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33783046
96BCAT_22108803_ChIP-Seq_LS180_Human1.33225621
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31654805
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31582262
99FOXM1_23109430_ChIP-Seq_U2OS_Human1.31077118
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30997355
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30997355
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30997355
103* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28473542
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27400185
105REST_21632747_ChIP-Seq_MESCs_Mouse1.27281588
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27261275
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27261275
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26587464
109POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25471589
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25319600
111AR_25329375_ChIP-Seq_VCAP_Human1.24484618
112TAF15_26573619_Chip-Seq_HEK293_Human1.24324337
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23652707
114ELK3_25401928_ChIP-Seq_HUVEC_Human1.21628717
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21392602
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21299582
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21222281
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21222281
119UBF1/2_26484160_Chip-Seq_HMECs_Human1.20716469
120* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20430614
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19512917
122STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17708103
123FLI1_27457419_Chip-Seq_LIVER_Mouse1.16737901
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16341688
125SMAD4_21741376_ChIP-Seq_HESCs_Human1.15778548
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15530616
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15186327
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14831307
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14420411
130ARNT_22903824_ChIP-Seq_MCF-7_Human1.13631902
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13493310
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13425822
133FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13092615
134PIAS1_25552417_ChIP-Seq_VCAP_Human1.13025814
135* RUNX2_22187159_ChIP-Seq_PCA_Human1.11336081
136KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11075509
137FUS_26573619_Chip-Seq_HEK293_Human1.10744808
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10256693
139SOX2_21211035_ChIP-Seq_LN229_Gbm1.08365392
140SOX2_20726797_ChIP-Seq_SW620_Human1.07763650
141SMAD3_21741376_ChIP-Seq_HESCs_Human1.07716464
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07566995
143TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07536156
144* TCF4_22108803_ChIP-Seq_LS180_Human1.07315869
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07030038
146NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06577048
147BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06329036
148PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05612737
149KDM2B_26808549_Chip-Seq_REH_Human1.04712908
150ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04490783
151* RNF2_27304074_Chip-Seq_NSC_Mouse1.04205633
152RXR_22108803_ChIP-Seq_LS180_Human1.03673826
153IGF1R_20145208_ChIP-Seq_DFB_Human1.03574823
154NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03280528
155STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02143570
156WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02107425
157PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01777435
158RING1B_27294783_Chip-Seq_ESCs_Mouse1.01354282
159SMAD3_21741376_ChIP-Seq_ESCs_Human1.00950103
160LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00886437
161PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99862312
162* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98411964
163AR_19668381_ChIP-Seq_PC3_Human0.98325882
164P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97850517
165ER_23166858_ChIP-Seq_MCF-7_Human0.97619944
166ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97415715
167CDX2_20551321_ChIP-Seq_CACO-2_Human0.97383584
168CBP_20019798_ChIP-Seq_JUKART_Human0.97283226
169TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97038910
170KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95963079
171TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95824949
172TP53_18474530_ChIP-ChIP_U2OS_Human0.95253449
173* TP63_23658742_ChIP-Seq_EP156T_Human0.94699245
174FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94353275
175TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94265499
176TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92760935
177GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91547671
178EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91344933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.84642387
2MP0004272_abnormal_basement_membrane3.99035334
3MP0001879_abnormal_lymphatic_vessel3.28662302
4MP0004084_abnormal_cardiac_muscle3.09562529
5MP0005623_abnormal_meninges_morphology2.87902713
6MP0003705_abnormal_hypodermis_morpholog2.61674973
7MP0003279_aneurysm2.34919776
8MP0005167_abnormal_blood-brain_barrier2.28944950
9MP0003828_pulmonary_edema2.13178515
10MP0006054_spinal_hemorrhage2.05316394
11MP0008438_abnormal_cutaneous_collagen2.05250826
12MP0006138_congestive_heart_failure2.02343499
13MP0004145_abnormal_muscle_electrophysio1.98412083
14MP0001486_abnormal_startle_reflex1.98362788
15MP0001501_abnormal_sleep_pattern1.97921965
16MP0003566_abnormal_cell_adhesion1.89159826
17MP0004885_abnormal_endolymph1.88069905
18MP0004215_abnormal_myocardial_fiber1.87860347
19MP0006276_abnormal_autonomic_nervous1.87495474
20MP0003941_abnormal_skin_development1.78137587
21MP0000767_abnormal_smooth_muscle1.76787142
22MP0002638_abnormal_pupillary_reflex1.76125077
23MP0010030_abnormal_orbit_morphology1.74442592
24MP0005595_abnormal_vascular_smooth1.70561159
25MP0001958_emphysema1.67918015
26MP0008775_abnormal_heart_ventricle1.65107016
27MP0004036_abnormal_muscle_relaxation1.64920499
28MP0010630_abnormal_cardiac_muscle1.63874899
29MP0010352_gastrointestinal_tract_polyps1.61711044
30MP0004484_altered_response_of1.57523890
31MP0002272_abnormal_nervous_system1.55760114
32MP0009745_abnormal_behavioral_response1.52958670
33MP0004085_abnormal_heartbeat1.52253569
34MP0000733_abnormal_muscle_development1.51041136
35MP0002925_abnormal_cardiovascular_devel1.49928754
36MP0003385_abnormal_body_wall1.48976050
37MP0001968_abnormal_touch/_nociception1.48096676
38MP0005551_abnormal_eye_electrophysiolog1.47797159
39MP0004133_heterotaxia1.45376235
40MP0009046_muscle_twitch1.45280732
41MP0002972_abnormal_cardiac_muscle1.43305624
42MP0003091_abnormal_cell_migration1.43020672
43MP0009053_abnormal_anal_canal1.42971626
44MP0000537_abnormal_urethra_morphology1.42758666
45MP0003880_abnormal_central_pattern1.42128080
46MP0005330_cardiomyopathy1.41964654
47MP0001544_abnormal_cardiovascular_syste1.41822122
48MP0005385_cardiovascular_system_phenoty1.41822122
49MP0009780_abnormal_chondrocyte_physiolo1.41633640
50MP0000751_myopathy1.36322899
51MP0002876_abnormal_thyroid_physiology1.35146613
52MP0000750_abnormal_muscle_regeneration1.33680275
53MP0003935_abnormal_craniofacial_develop1.33668694
54MP0002138_abnormal_hepatobiliary_system1.33619919
55MP0003136_yellow_coat_color1.33281472
56MP0005670_abnormal_white_adipose1.33000426
57MP0005503_abnormal_tendon_morphology1.31842989
58MP0002064_seizures1.31573188
59MP0000778_abnormal_nervous_system1.31071980
60MP0002128_abnormal_blood_circulation1.30140423
61MP0003984_embryonic_growth_retardation1.27795981
62MP0005620_abnormal_muscle_contractility1.27094706
63MP0003635_abnormal_synaptic_transmissio1.26574953
64MP0009278_abnormal_bone_marrow1.26563330
65MP0004087_abnormal_muscle_fiber1.26128452
66MP0005423_abnormal_somatic_nervous1.25332627
67MP0002088_abnormal_embryonic_growth/wei1.24368313
68MP0000266_abnormal_heart_morphology1.23580326
69MP0004782_abnormal_surfactant_physiolog1.23365298
70MP0005275_abnormal_skin_tensile1.22968440
71MP0002127_abnormal_cardiovascular_syste1.22935418
72MP0003283_abnormal_digestive_organ1.22748243
73MP0005187_abnormal_penis_morphology1.21846206
74MP0000534_abnormal_ureter_morphology1.21530334
75MP0001614_abnormal_blood_vessel1.21245018
76MP0003937_abnormal_limbs/digits/tail_de1.21223268
77MP0002572_abnormal_emotion/affect_behav1.21187155
78MP0005248_abnormal_Harderian_gland1.20761369
79MP0003123_paternal_imprinting1.20472631
80MP0003195_calcinosis1.20454957
81MP0003567_abnormal_fetal_cardiomyocyte1.20071332
82MP0001915_intracranial_hemorrhage1.19523195
83MP0001502_abnormal_circadian_rhythm1.18975728
84MP0002837_dystrophic_cardiac_calcinosis1.18684630
85MP0001485_abnormal_pinna_reflex1.18547564
86MP0003950_abnormal_plasma_membrane1.18520172
87MP0003121_genomic_imprinting1.18302205
88MP0000230_abnormal_systemic_arterial1.18142231
89MP0002086_abnormal_extraembryonic_tissu1.17703797
90MP0002063_abnormal_learning/memory/cond1.17309117
91MP0001672_abnormal_embryogenesis/_devel1.12731714
92MP0005380_embryogenesis_phenotype1.12731714
93MP0002733_abnormal_thermal_nociception1.11833913
94MP0009384_cardiac_valve_regurgitation1.10527928
95MP0003122_maternal_imprinting1.10120995
96MP0009250_abnormal_appendicular_skeleto1.09492361
97MP0002067_abnormal_sensory_capabilities1.07621052
98MP0001984_abnormal_olfaction1.07358156
99MP0005367_renal/urinary_system_phenotyp1.04429643
100MP0000516_abnormal_urinary_system1.04429643
101MP0002295_abnormal_pulmonary_circulatio1.04086092
102MP0005508_abnormal_skeleton_morphology1.02630493
103MP0002557_abnormal_social/conspecific_i1.02626432
104MP0001970_abnormal_pain_threshold1.02381296
105MP0000383_abnormal_hair_follicle1.01279001
106MP0001440_abnormal_grooming_behavior1.00621118
107MP0004130_abnormal_muscle_cell0.99643347
108MP0002933_joint_inflammation0.99200709
109MP0003137_abnormal_impulse_conducting0.98978523
110MP0000049_abnormal_middle_ear0.98208875
111MP0000631_abnormal_neuroendocrine_gland0.98037801
112MP0004043_abnormal_pH_regulation0.97738917
113MP0000026_abnormal_inner_ear0.97076003
114MP0002736_abnormal_nociception_after0.96445558
115MP0004859_abnormal_synaptic_plasticity0.95782498
116MP0003115_abnormal_respiratory_system0.95042694
117MP0004924_abnormal_behavior0.94817761
118MP0005386_behavior/neurological_phenoty0.94817761
119MP0002084_abnormal_developmental_patter0.94636697
120MP0005666_abnormal_adipose_tissue0.94332662
121MP0009697_abnormal_copulation0.93978215
122MP0000465_gastrointestinal_hemorrhage0.92548035
123MP0002735_abnormal_chemical_nociception0.92381687
124MP0000749_muscle_degeneration0.92275447
125MP0002896_abnormal_bone_mineralization0.92133303
126MP0003942_abnormal_urinary_system0.91966637
127MP0001784_abnormal_fluid_regulation0.91447843
128MP0004808_abnormal_hematopoietic_stem0.91351628
129MP0005646_abnormal_pituitary_gland0.91241994
130MP0004270_analgesia0.90689271
131MP0002249_abnormal_larynx_morphology0.90312052
132MP0005165_increased_susceptibility_to0.90043621
133MP0000013_abnormal_adipose_tissue0.90014420
134MP0000432_abnormal_head_morphology0.89976365
135MP0003633_abnormal_nervous_system0.89465300
136MP0003755_abnormal_palate_morphology0.88805969
137MP0004197_abnormal_fetal_growth/weight/0.88548058
138MP0002108_abnormal_muscle_morphology0.88253835
139MP0001177_atelectasis0.87863385
140MP0000343_altered_response_to0.86866843
141MP0003646_muscle_fatigue0.86719215
142MP0004185_abnormal_adipocyte_glucose0.86529119
143MP0000003_abnormal_adipose_tissue0.86167908
144MP0002085_abnormal_embryonic_tissue0.86084298
145MP0005023_abnormal_wound_healing0.84654739
146MP0005171_absent_coat_pigmentation0.84409330
147MP0004147_increased_porphyrin_level0.83976495
148MP0005076_abnormal_cell_differentiation0.83518893
149MP0001963_abnormal_hearing_physiology0.83498117
150MP0005195_abnormal_posterior_eye0.81930595
151MP0003300_gastrointestinal_ulcer0.81844434
152MP0003119_abnormal_digestive_system0.81562901
153MP0003879_abnormal_hair_cell0.81559250
154MP0001986_abnormal_taste_sensitivity0.81092832
155MP0003045_fibrosis0.80914701
156MP0003943_abnormal_hepatobiliary_system0.79874341
157MP0008995_early_reproductive_senescence0.79715593
158MP0005084_abnormal_gallbladder_morpholo0.78944516
159MP0002102_abnormal_ear_morphology0.78864604
160MP0002168_other_aberrant_phenotype0.78684847
161MP0001697_abnormal_embryo_size0.78150090
162MP0002752_abnormal_somatic_nervous0.77756537
163MP0004142_abnormal_muscle_tone0.76304397
164MP0003690_abnormal_glial_cell0.76290607
165MP0005253_abnormal_eye_physiology0.75795033
166MP0002133_abnormal_respiratory_system0.75034780

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)4.02428794
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.75123685
3Short 4th metacarpal (HP:0010044)3.75123685
4Hyperventilation (HP:0002883)3.57418058
5Increased connective tissue (HP:0009025)3.36652735
6Tubular atrophy (HP:0000092)3.36173756
7Shallow orbits (HP:0000586)3.26390370
8Genetic anticipation (HP:0003743)3.23813720
9Cerebral aneurysm (HP:0004944)3.16559249
10Broad metatarsal (HP:0001783)3.16049699
11Lymphangioma (HP:0100764)3.09201935
12Protrusio acetabuli (HP:0003179)3.08906063
13Abnormality of the 4th metacarpal (HP:0010012)3.05902032
14Decreased circulating renin level (HP:0003351)3.04258432
15Nephronophthisis (HP:0000090)3.00259501
16Thyroid-stimulating hormone excess (HP:0002925)2.96838748
17Ventricular tachycardia (HP:0004756)2.92131751
18Abnormality of the renal medulla (HP:0100957)2.91427862
19Type II lissencephaly (HP:0007260)2.90388332
20Cerebellar dysplasia (HP:0007033)2.87690189
21Atrial fibrillation (HP:0005110)2.82294041
22Abnormality of midbrain morphology (HP:0002418)2.82095702
23Molar tooth sign on MRI (HP:0002419)2.82095702
24Increased corneal curvature (HP:0100692)2.79855615
25Keratoconus (HP:0000563)2.79855615
26Progressive cerebellar ataxia (HP:0002073)2.78200874
27Hematochezia (HP:0002573)2.77587238
28Premature rupture of membranes (HP:0001788)2.76930345
29Right ventricular cardiomyopathy (HP:0011663)2.76720874
30Hyporeflexia of lower limbs (HP:0002600)2.67900707
31Sudden death (HP:0001699)2.64229936
32Primary atrial arrhythmia (HP:0001692)2.60537405
33Pancreatic cysts (HP:0001737)2.60134010
34Skull defect (HP:0001362)2.59251891
35Supraventricular arrhythmia (HP:0005115)2.58584781
36True hermaphroditism (HP:0010459)2.57132034
37Aortic aneurysm (HP:0004942)2.56841688
38Ankle contracture (HP:0006466)2.54192789
39Esophageal varix (HP:0002040)2.52793873
40Cutaneous finger syndactyly (HP:0010554)2.47710018
41Abnormality of the renal cortex (HP:0011035)2.47446837
42Pancreatic fibrosis (HP:0100732)2.47177586
43Decreased central vision (HP:0007663)2.45902462
44Hip contracture (HP:0003273)2.44440397
45Focal seizures (HP:0007359)2.44037769
46Lipoatrophy (HP:0100578)2.43790476
47Aneurysm (HP:0002617)2.43290981
48Hypoplastic ischia (HP:0003175)2.43153732
49Broad-based gait (HP:0002136)2.42773191
50Hyperkalemia (HP:0002153)2.42733643
51Tachypnea (HP:0002789)2.42507525
52Abnormal drinking behavior (HP:0030082)2.41762951
53Polydipsia (HP:0001959)2.41762951
54Supraventricular tachycardia (HP:0004755)2.39885133
55Bundle branch block (HP:0011710)2.38701664
56Shawl scrotum (HP:0000049)2.35547127
57Hypoplasia of the iris (HP:0007676)2.34856758
58Clumsiness (HP:0002312)2.33071232
59Congenital hepatic fibrosis (HP:0002612)2.32596954
60Focal motor seizures (HP:0011153)2.31779317
61Abnormality of renin-angiotensin system (HP:0000847)2.31651465
62Abolished electroretinogram (ERG) (HP:0000550)2.30963713
63Febrile seizures (HP:0002373)2.28999208
64Adactyly (HP:0009776)2.28388153
65Congenital stationary night blindness (HP:0007642)2.27181618
66Aortic dissection (HP:0002647)2.26728021
67Bulbous nose (HP:0000414)2.23331436
68Gaze-evoked nystagmus (HP:0000640)2.22922259
69Polycythemia (HP:0001901)2.22907843
70Myotonia (HP:0002486)2.21790455
71Cystic liver disease (HP:0006706)2.20702497
72Chronic hepatic failure (HP:0100626)2.19348734
73Stenosis of the external auditory canal (HP:0000402)2.18563973
74Atonic seizures (HP:0010819)2.16885657
75Abnormality of the ischium (HP:0003174)2.16589344
76Tubulointerstitial fibrosis (HP:0005576)2.15149158
77Enlarged penis (HP:0000040)2.13673061
78Atrophic scars (HP:0001075)2.12590194
79Mesangial abnormality (HP:0001966)2.11558583
80Portal hypertension (HP:0001409)2.11106727
81Limited hip movement (HP:0008800)2.10369788
82Wrist flexion contracture (HP:0001239)2.09810172
83Camptodactyly of toe (HP:0001836)2.09019008
84Tubulointerstitial abnormality (HP:0001969)2.07653486
85Asymmetry of the thorax (HP:0001555)2.05270544
86Rectal prolapse (HP:0002035)2.05158371
87Neonatal death (HP:0003811)2.05022476
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.04406507
89Spinal rigidity (HP:0003306)2.03657056
90Difficulty running (HP:0009046)2.03299248
91Abnormality of the calf musculature (HP:0001430)2.02396604
92Cutaneous syndactyly (HP:0012725)2.01709750
93Abnormality of the hepatic vasculature (HP:0006707)2.00929206
94Syncope (HP:0001279)2.00763916
95Hypokalemic alkalosis (HP:0001949)1.99033752
96Mitral valve prolapse (HP:0001634)1.98073785
97Abnormality of chloride homeostasis (HP:0011422)1.97575107
98Abnormality of the distal phalanx of the thumb (HP:0009617)1.96919938
99Hemiparesis (HP:0001269)1.95882963
100Abnormality of potassium homeostasis (HP:0011042)1.95504015
101Prolonged QT interval (HP:0001657)1.95251895
102Heart block (HP:0012722)1.94696106
103Aplasia/Hypoplasia of the tibia (HP:0005772)1.93201005
104Absent speech (HP:0001344)1.92571837
105Subacute progressive viral hepatitis (HP:0006572)1.91979908
106Hyperaldosteronism (HP:0000859)1.91365682
107Knee flexion contracture (HP:0006380)1.91069513
108Tubulointerstitial nephritis (HP:0001970)1.91057378
109Polyuria (HP:0000103)1.90725253
110Scapular winging (HP:0003691)1.89986807
111Thin bony cortex (HP:0002753)1.89986113
112Ulnar claw (HP:0001178)1.89741778
113Abnormality of the vitreous humor (HP:0004327)1.89258889
114Aplasia cutis congenita (HP:0001057)1.86762284
115Pachygyria (HP:0001302)1.86452860
116Cervical subluxation (HP:0003308)1.85621918
117Occipital encephalocele (HP:0002085)1.84464579
118Difficulty climbing stairs (HP:0003551)1.83924691
119Long eyelashes (HP:0000527)1.83377381
120Short hallux (HP:0010109)1.83050303
121Urethral obstruction (HP:0000796)1.82188945
122Exercise-induced muscle cramps (HP:0003710)1.82111038
123Chondrocalcinosis (HP:0000934)1.81649570
124Abnormality of the nasal septum (HP:0000419)1.81216107
125Distal lower limb muscle weakness (HP:0009053)1.81118985
126Congenital sensorineural hearing impairment (HP:0008527)1.80733725
127Action tremor (HP:0002345)1.80715163
128Metabolic alkalosis (HP:0200114)1.80701924
129Abnormality of the renal collecting system (HP:0004742)1.80670215
130Bladder diverticulum (HP:0000015)1.79815376
131Abnormal atrioventricular conduction (HP:0005150)1.79676836
132Hyperactive renin-angiotensin system (HP:0000841)1.79182709
133Absent hand (HP:0004050)1.79128976
134Vascular tortuosity (HP:0004948)1.78988977
135Focal segmental glomerulosclerosis (HP:0000097)1.78170680
136Pulmonary artery stenosis (HP:0004415)1.77561893
137Increased variability in muscle fiber diameter (HP:0003557)1.76927954
138Subaortic stenosis (HP:0001682)1.76885605
139Abnormality of the left ventricular outflow tract (HP:0011103)1.76885605
140Capillary hemangiomas (HP:0005306)1.76881638
141Broad toe (HP:0001837)1.76222202
142Aortic valve stenosis (HP:0001650)1.76031192
143Papillary thyroid carcinoma (HP:0002895)1.75987797
144Midline defect of the nose (HP:0004122)1.75397301
145Retinal atrophy (HP:0001105)1.75270409
146Abnormality of the right ventricle (HP:0001707)1.74672755
147Wide anterior fontanel (HP:0000260)1.73981914
148Mesomelia (HP:0003027)1.73696084
149Protruding tongue (HP:0010808)1.73260448
150Inability to walk (HP:0002540)1.72866823
151Soft skin (HP:0000977)1.72773796
152Broad hallux (HP:0010055)1.72335958
153Widely spaced teeth (HP:0000687)1.72173442
154Stage 5 chronic kidney disease (HP:0003774)1.71627980
155Broad thumb (HP:0011304)1.70451483
156Increased circulating renin level (HP:0000848)1.70388824
157Advanced eruption of teeth (HP:0006288)1.69721142
158Abnormality of Sharpey fibers (HP:0100685)1.69117447
159Retinal dysplasia (HP:0007973)1.68627683
160Arterial tortuosity (HP:0005116)1.68543991
161Dilated cardiomyopathy (HP:0001644)1.68257348
162Hypokalemia (HP:0002900)1.66857943
163Joint laxity (HP:0001388)1.66171527
164Metaphyseal cupping (HP:0003021)1.65685080
165Absent eyebrow (HP:0002223)1.65172828
166Syringomyelia (HP:0003396)1.64863258
167Spinal cord lesions (HP:0100561)1.64863258
168Joint contractures involving the joints of the feet (HP:0100492)1.64615479
169Flexion contracture of toe (HP:0005830)1.64615479
170Congenital, generalized hypertrichosis (HP:0004540)1.64194543
171Exostoses (HP:0100777)1.64151930
172Absent toe (HP:0010760)1.63862017
173Hepatoblastoma (HP:0002884)1.63445105
174Dilatation of the ascending aorta (HP:0005111)1.63281698
175Overgrowth (HP:0001548)1.63210549
176Aplasia/Hypoplasia of the hallux (HP:0008362)1.61548638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.48392491
2LATS14.68069591
3KDR3.59242907
4TTN3.25377833
5STK38L2.80352954
6PINK12.42197706
7DAPK22.32558167
8TGFBR22.29627825
9LATS22.29149021
10DMPK2.18377832
11WNK42.10334123
12RIPK12.06009130
13TNIK2.04120697
14EPHB22.02988531
15PDGFRA2.02868863
16TGFBR11.97825904
17STK31.86956402
18PKN21.83205895
19TRIB31.79851099
20BMPR1B1.76543744
21CDK121.72471568
22ADRBK21.65542966
23MARK11.59780698
24CASK1.54786332
25CAMK1D1.50419743
26PTK2B1.48532610
27GRK11.39107196
28NLK1.37625999
29NUAK11.32816613
30WNK31.30131660
31PTK61.27736839
32EPHA21.27020058
33PTK21.26577057
34FER1.25996506
35PDK21.25273678
36MAPK131.23274410
37NTRK31.22799853
38PAK41.22346486
39FRK1.21892797
40PHKG21.19182300
41PHKG11.19182300
42PRKCE1.17647581
43MAP3K41.17605028
44FGFR21.17497256
45PLK41.16693738
46SGK21.15905845
47STK101.15332609
48TAOK31.14401372
49MYLK1.13946056
50DDR21.13185417
51SGK2231.10262649
52SGK4941.10262649
53FES1.07010271
54EPHA41.06177296
55ACVR1B1.03387270
56NTRK21.02461592
57PDGFRB1.02292494
58LRRK21.01035148
59MAP3K30.99960445
60STK110.98291593
61MTOR0.97759224
62TRPM70.95665156
63MAP4K20.95207899
64STK380.93850471
65NTRK10.93310649
66CAMK1G0.92105993
67INSRR0.90418566
68AKT30.90338743
69PRKD30.88620397
70MARK20.87386224
71OBSCN0.86966751
72CAMK10.86294594
73ADRBK10.84642709
74PIK3CA0.83973416
75PRKAA20.81167839
76LMTK20.79674061
77STK240.77545810
78PAK20.75733580
79MET0.74948115
80NEK90.74741618
81PKN10.74393206
82ROCK10.73560557
83OXSR10.72772496
84WNK10.72629312
85PRKG20.72024758
86PRKCG0.71023696
87FGFR30.70382441
88ZAK0.70235788
89PRKD10.69926224
90TEC0.69629274
91FGFR10.67842551
92PAK30.66971096
93ERBB20.65235684
94MAPK150.65187711
95PNCK0.65094335
96RPS6KA20.63368411
97PDK30.62582841
98PDK40.62582841
99CAMK2A0.62140616
100MAP2K30.61926990
101EPHA30.61040480
102BMX0.59639888
103MUSK0.58518512
104CDK60.57611643
105CDC70.57153476
106CAMK40.55928820
107SGK10.54520889
108STK390.53063377
109MAPK120.52564616
110DYRK1A0.52159878
111PAK60.51825496
112RPS6KB20.50898655
113ERBB40.50697386
114PRKG10.50528229
115MAPK70.49255082
116NEK10.48625218
117SIK10.48474963
118PRKD20.47934107
119MAPKAPK50.47896769
120BCR0.47316975
121PRKAA10.46878426
122PRKACA0.46650515
123EEF2K0.45366251
124CDK90.45324710
125UHMK10.44879664
126CDK50.44632973
127TTK0.44566303
128RPS6KA60.44493042
129MAPKAPK30.43493410
130PLK20.43243111
131PIK3CG0.42068091
132RPS6KA30.41959541
133CAMKK10.40746651
134ITK0.39455384
135CAMK2D0.39429794
136AKT20.39311530
137RET0.38717203
138ILK0.38565727
139IGF1R0.37647352
140GSK3A0.36237572
141SGK30.34376244
142TYRO30.33629443
143MAP3K60.33120548
144NEK20.32540033
145STK40.32273917
146INSR0.31608644
147PRKCH0.31244007
148ABL10.30843002
149CDK80.29880090
150CHUK0.29253044
151AURKB0.28659456
152BRD40.28267538
153EPHB10.27574813
154ERBB30.26650437
155MAP3K70.26249951

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.44727327
2Adherens junction_Homo sapiens_hsa045203.28460616
3Focal adhesion_Homo sapiens_hsa045102.80008801
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.71311044
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.70748523
6Dilated cardiomyopathy_Homo sapiens_hsa054142.69388090
7Small cell lung cancer_Homo sapiens_hsa052222.38910391
8Hippo signaling pathway_Homo sapiens_hsa043902.15894569
9Nicotine addiction_Homo sapiens_hsa050332.09503721
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07498141
11Proteoglycans in cancer_Homo sapiens_hsa052052.02107272
12Basal cell carcinoma_Homo sapiens_hsa052171.96884810
13Linoleic acid metabolism_Homo sapiens_hsa005911.94473392
14TGF-beta signaling pathway_Homo sapiens_hsa043501.89534154
15Glutamatergic synapse_Homo sapiens_hsa047241.87710353
16MicroRNAs in cancer_Homo sapiens_hsa052061.84647716
17Morphine addiction_Homo sapiens_hsa050321.84236769
18Circadian entrainment_Homo sapiens_hsa047131.77250566
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76342783
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.74983787
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71299430
22Viral myocarditis_Homo sapiens_hsa054161.71123880
23Lysine degradation_Homo sapiens_hsa003101.70694207
24Phototransduction_Homo sapiens_hsa047441.68760939
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.66157083
26Ether lipid metabolism_Homo sapiens_hsa005651.65259736
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.64235200
28* Tight junction_Homo sapiens_hsa045301.63976320
29GABAergic synapse_Homo sapiens_hsa047271.62073040
30Insulin secretion_Homo sapiens_hsa049111.61292252
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60405202
32Taste transduction_Homo sapiens_hsa047421.59191610
33Nitrogen metabolism_Homo sapiens_hsa009101.58017773
34Protein digestion and absorption_Homo sapiens_hsa049741.57286335
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55636518
36Amoebiasis_Homo sapiens_hsa051461.54408585
37ABC transporters_Homo sapiens_hsa020101.51922016
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50168893
39Rap1 signaling pathway_Homo sapiens_hsa040151.49468776
40Serotonergic synapse_Homo sapiens_hsa047261.49374149
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47395726
42Notch signaling pathway_Homo sapiens_hsa043301.47386675
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.45538942
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43924324
45Dorso-ventral axis formation_Homo sapiens_hsa043201.40820679
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37443152
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.36496169
48Butanoate metabolism_Homo sapiens_hsa006501.36196230
49Pathways in cancer_Homo sapiens_hsa052001.35253880
50Hedgehog signaling pathway_Homo sapiens_hsa043401.34612905
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28006210
52Salivary secretion_Homo sapiens_hsa049701.27973815
53Calcium signaling pathway_Homo sapiens_hsa040201.24551146
54Gastric acid secretion_Homo sapiens_hsa049711.24133820
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23833133
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23759393
57Propanoate metabolism_Homo sapiens_hsa006401.21137427
58Ovarian steroidogenesis_Homo sapiens_hsa049131.20984509
59Tryptophan metabolism_Homo sapiens_hsa003801.18894661
60Cardiac muscle contraction_Homo sapiens_hsa042601.18266943
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16064175
62Melanoma_Homo sapiens_hsa052181.14358007
63Histidine metabolism_Homo sapiens_hsa003401.14127814
64HIF-1 signaling pathway_Homo sapiens_hsa040661.13413453
65Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13380355
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12759028
67Axon guidance_Homo sapiens_hsa043601.11751811
68Platelet activation_Homo sapiens_hsa046111.10441743
69Insulin resistance_Homo sapiens_hsa049311.08065621
70Wnt signaling pathway_Homo sapiens_hsa043101.07277079
71Prostate cancer_Homo sapiens_hsa052151.05446220
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03896179
73Thyroid cancer_Homo sapiens_hsa052161.02748179
74Renal cell carcinoma_Homo sapiens_hsa052111.02127688
75Olfactory transduction_Homo sapiens_hsa047401.01139089
76Long-term depression_Homo sapiens_hsa047301.00310772
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.97397847
78Cell cycle_Homo sapiens_hsa041100.96983704
79Toxoplasmosis_Homo sapiens_hsa051450.95063011
80FoxO signaling pathway_Homo sapiens_hsa040680.94747713
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94569550
82Pancreatic cancer_Homo sapiens_hsa052120.94460494
83Cocaine addiction_Homo sapiens_hsa050300.94218787
84Chronic myeloid leukemia_Homo sapiens_hsa052200.94128535
85Cholinergic synapse_Homo sapiens_hsa047250.93986857
86HTLV-I infection_Homo sapiens_hsa051660.93431449
87Dopaminergic synapse_Homo sapiens_hsa047280.92741147
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92703585
89beta-Alanine metabolism_Homo sapiens_hsa004100.92603500
90Bladder cancer_Homo sapiens_hsa052190.91792306
91Endometrial cancer_Homo sapiens_hsa052130.88623102
92Thyroid hormone synthesis_Homo sapiens_hsa049180.88483038
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86902791
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85894511
95p53 signaling pathway_Homo sapiens_hsa041150.84690461
96Fatty acid degradation_Homo sapiens_hsa000710.84371092
97Ras signaling pathway_Homo sapiens_hsa040140.84036313
98Malaria_Homo sapiens_hsa051440.83273652
99Arachidonic acid metabolism_Homo sapiens_hsa005900.81492432
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78230767
101Melanogenesis_Homo sapiens_hsa049160.78159001
102Selenocompound metabolism_Homo sapiens_hsa004500.77636962
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75208785
104Pancreatic secretion_Homo sapiens_hsa049720.75096554
105Colorectal cancer_Homo sapiens_hsa052100.74024833
106VEGF signaling pathway_Homo sapiens_hsa043700.73748319
107PPAR signaling pathway_Homo sapiens_hsa033200.73712303
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73675617
109Glycerolipid metabolism_Homo sapiens_hsa005610.73437636
110AMPK signaling pathway_Homo sapiens_hsa041520.72471967
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68205946
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68054096
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.67798157
114Amphetamine addiction_Homo sapiens_hsa050310.67123241
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.66230307
116Vitamin digestion and absorption_Homo sapiens_hsa049770.65545318
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63751713
118Circadian rhythm_Homo sapiens_hsa047100.61547203
119Mineral absorption_Homo sapiens_hsa049780.61490517
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.59362727
121Glioma_Homo sapiens_hsa052140.59171065
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59165657
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.58904998
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.58839235
125Complement and coagulation cascades_Homo sapiens_hsa046100.57669653
126TNF signaling pathway_Homo sapiens_hsa046680.56635177
127Gap junction_Homo sapiens_hsa045400.56542971
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55174069
129GnRH signaling pathway_Homo sapiens_hsa049120.54775363
130Choline metabolism in cancer_Homo sapiens_hsa052310.54194711
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.53674775
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53244158
133Shigellosis_Homo sapiens_hsa051310.53243643
134mTOR signaling pathway_Homo sapiens_hsa041500.52820937
135Estrogen signaling pathway_Homo sapiens_hsa049150.52139716
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51978261
137Fatty acid metabolism_Homo sapiens_hsa012120.51719706
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51558341
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49187525
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48712139
141Bile secretion_Homo sapiens_hsa049760.48225830
142Arginine and proline metabolism_Homo sapiens_hsa003300.47920075
143cAMP signaling pathway_Homo sapiens_hsa040240.45854439
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.45528883
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45058219
146Glucagon signaling pathway_Homo sapiens_hsa049220.43581559
147Peroxisome_Homo sapiens_hsa041460.42730013
148Sphingolipid metabolism_Homo sapiens_hsa006000.42417963
149Insulin signaling pathway_Homo sapiens_hsa049100.41180940
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40768476
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39260524
152MAPK signaling pathway_Homo sapiens_hsa040100.38507808
153Viral carcinogenesis_Homo sapiens_hsa052030.38206873
154Salmonella infection_Homo sapiens_hsa051320.37888325
155Renin secretion_Homo sapiens_hsa049240.34789135
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.34639304
157Oxytocin signaling pathway_Homo sapiens_hsa049210.34267553

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