SI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)9.23111871
2lipoprotein transport (GO:0042953)7.58071398
3regulation of guanylate cyclase activity (GO:0031282)7.47541817
4NADH metabolic process (GO:0006734)7.11034701
5regulation of bile acid biosynthetic process (GO:0070857)6.87743787
6intestinal absorption (GO:0050892)6.78407755
7epoxygenase P450 pathway (GO:0019373)6.70810328
8fat-soluble vitamin biosynthetic process (GO:0042362)6.53450818
9positive regulation of guanylate cyclase activity (GO:0031284)5.80204867
10hormone catabolic process (GO:0042447)5.68113878
11regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.61524690
12endocrine process (GO:0050886)5.61524690
13regulation of systemic arterial blood pressure by hormone (GO:0001990)5.61524690
14fructose metabolic process (GO:0006000)5.54520939
15regulation of cellular extravasation (GO:0002691)5.41808230
16virion attachment to host cell (GO:0019062)5.27917534
17adhesion of symbiont to host cell (GO:0044650)5.27917534
18regulation of systemic arterial blood pressure (GO:0003073)5.07578057
19drug metabolic process (GO:0017144)4.84473806
20peptide hormone processing (GO:0016486)4.78041844
21cellular glucuronidation (GO:0052695)4.73487178
22receptor guanylyl cyclase signaling pathway (GO:0007168)4.65698048
23uronic acid metabolic process (GO:0006063)4.65624976
24glucuronate metabolic process (GO:0019585)4.65624976
25diacylglycerol metabolic process (GO:0046339)4.64631668
26urea cycle (GO:0000050)4.64366692
27regulation of triglyceride catabolic process (GO:0010896)4.62919565
28very-low-density lipoprotein particle assembly (GO:0034379)4.59162255
29regulation of cGMP biosynthetic process (GO:0030826)4.57071514
30peptide catabolic process (GO:0043171)4.50204081
31adhesion of symbiont to host (GO:0044406)4.47832826
32bile acid and bile salt transport (GO:0015721)4.44831096
33urea metabolic process (GO:0019627)4.42689623
34glycolipid catabolic process (GO:0019377)4.33029339
35glycosphingolipid catabolic process (GO:0046479)4.31498216
36vitamin A metabolic process (GO:0006776)4.28473485
37antibacterial humoral response (GO:0019731)4.27861366
38regulation of vitamin metabolic process (GO:0030656)4.25519373
39antimicrobial humoral response (GO:0019730)4.12739883
40renal system process involved in regulation of blood volume (GO:0001977)4.11506643
41plasma lipoprotein particle assembly (GO:0034377)4.08215919
42nitrogen cycle metabolic process (GO:0071941)4.06729557
43drinking behavior (GO:0042756)4.04287957
44maintenance of gastrointestinal epithelium (GO:0030277)4.00568582
45flavonoid metabolic process (GO:0009812)3.95395263
46* digestion (GO:0007586)3.85408061
47cellular response to nitric oxide (GO:0071732)3.84662029
48regulation of cGMP metabolic process (GO:0030823)3.79370296
49alkaloid metabolic process (GO:0009820)3.76303254
50lipoprotein metabolic process (GO:0042157)3.74757649
51vitamin transmembrane transport (GO:0035461)3.73290686
52homocysteine metabolic process (GO:0050667)3.72739756
53protein-lipid complex assembly (GO:0065005)3.72453150
54fat-soluble vitamin metabolic process (GO:0006775)3.67346124
55positive regulation of glycoprotein biosynthetic process (GO:0010560)3.65837833
56positive regulation of pseudopodium assembly (GO:0031274)3.64816618
57drug catabolic process (GO:0042737)3.58674197
58vitamin transport (GO:0051180)3.58570770
59midgut development (GO:0007494)3.56793979
60glutamine family amino acid biosynthetic process (GO:0009084)3.55579357
61ceramide catabolic process (GO:0046514)3.47984003
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.42137504
63response to nitric oxide (GO:0071731)3.42059584
64mRNA modification (GO:0016556)3.41036124
65exogenous drug catabolic process (GO:0042738)3.38729571
66positive regulation of cGMP biosynthetic process (GO:0030828)3.38672805
67arginine metabolic process (GO:0006525)3.37552191
68glycosylceramide metabolic process (GO:0006677)3.37246022
69digestive system process (GO:0022600)3.35620465
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.35291273
71cGMP biosynthetic process (GO:0006182)3.34943004
72bile acid metabolic process (GO:0008206)3.33724231
73cellular response to reactive nitrogen species (GO:1902170)3.33176875
74phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.30405822
75regulation of cholesterol homeostasis (GO:2000188)3.28518092
76positive regulation of glycoprotein metabolic process (GO:1903020)3.28237380
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.26617279
78regulation of pseudopodium assembly (GO:0031272)3.26431313
79cGMP-mediated signaling (GO:0019934)3.25116142
80glomerulus development (GO:0032835)3.23988890
81phospholipid efflux (GO:0033700)3.22765090
82sexual reproduction (GO:0019953)3.22685242
83sphingolipid catabolic process (GO:0030149)3.22267990
84citrulline biosynthetic process (GO:0019240)3.20856998
85drug transport (GO:0015893)3.17875025
86vitamin biosynthetic process (GO:0009110)3.17481709
87actin filament depolymerization (GO:0030042)3.16503217
88glycerol metabolic process (GO:0006071)3.14415723
89antigen processing and presentation of endogenous antigen (GO:0019883)3.13557581
90sphingomyelin metabolic process (GO:0006684)3.13292375
91transcytosis (GO:0045056)3.13012446
92sulfate transmembrane transport (GO:1902358)3.11990011
93regulation of cholesterol esterification (GO:0010872)3.10234353
94nucleoside diphosphate biosynthetic process (GO:0009133)3.08989812
95cobalamin metabolic process (GO:0009235)3.07942675
96membrane lipid catabolic process (GO:0046466)3.07829154
97vitamin D metabolic process (GO:0042359)3.07465460
98positive regulation of lipoprotein lipase activity (GO:0051006)3.06676698
99positive regulation of triglyceride lipase activity (GO:0061365)3.06676698
100angiotensin maturation (GO:0002003)12.0025869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.42732977
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.25659580
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.83465401
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.17963326
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.13311776
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.03818811
7GATA4_25053715_ChIP-Seq_YYC3_Human3.02733050
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.55317055
9GATA1_22025678_ChIP-Seq_K562_Human2.53950916
10GATA6_25053715_ChIP-Seq_YYC3_Human2.53479392
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.46577770
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.46262763
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.45714827
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.40930856
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.27306872
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.26077339
17SOX2_20726797_ChIP-Seq_SW620_Human2.25047126
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.24089039
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.23281228
20BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.08411749
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94040154
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.92131823
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88322764
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80898840
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.80561637
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.78583808
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68353343
28PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.63296077
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.60516810
30* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.57967712
31TCF4_18268006_ChIP-ChIP_LS174T_Human1.55707205
32CLOCK_20551151_ChIP-Seq_293T_Human1.54209853
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52782763
34LXR_22292898_ChIP-Seq_THP-1_Human1.44737388
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.42947710
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34445512
37CDX2_22108803_ChIP-Seq_LS180_Human1.33137442
38HNF4A_19822575_ChIP-Seq_HepG2_Human1.32965843
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29639892
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28679282
41GATA2_19941826_ChIP-Seq_K562_Human1.27061447
42* FOXA1_25552417_ChIP-Seq_VCAP_Human1.22825490
43ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21842746
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17955409
45BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.17950230
46AR_21909140_ChIP-Seq_LNCAP_Human1.16548930
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15015710
48RXR_22108803_ChIP-Seq_LS180_Human1.10408251
49KLF5_25053715_ChIP-Seq_YYC3_Human1.10142499
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09726145
51GATA1_19941826_ChIP-Seq_K562_Human1.08519719
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.08342088
53RACK7_27058665_Chip-Seq_MCF-7_Human1.06009124
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05111796
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04789003
56EGR1_19032775_ChIP-ChIP_M12_Human1.01149026
57* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01085432
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00657534
59VDR_24787735_ChIP-Seq_THP-1_Human0.98155554
60JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98005356
61GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95972050
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95158600
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94109879
64BCOR_27268052_Chip-Seq_Bcells_Human0.93457529
65P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93424038
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93357749
67SA1_27219007_Chip-Seq_Bcells_Human0.93173239
68BCL6_27268052_Chip-Seq_Bcells_Human0.91248055
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90354925
70ESR1_21235772_ChIP-Seq_MCF-7_Human0.90343102
71TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89917286
72TET1_21451524_ChIP-Seq_MESCs_Mouse0.89390422
73NANOG_20526341_ChIP-Seq_ESCs_Human0.89119333
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88546170
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88502436
76RUNX1_27514584_Chip-Seq_MCF-7_Human0.88340543
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86272073
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86163877
79CEBPB_22108803_ChIP-Seq_LS180_Human0.85802168
80TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85425699
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84909800
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83544709
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83489158
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80511821
85VDR_24763502_ChIP-Seq_THP-1_Human0.80280354
86TP63_23658742_ChIP-Seq_EP156T_Human0.79960439
87IRF8_27001747_Chip-Seq_BMDM_Mouse0.79464169
88CTCF_27219007_Chip-Seq_Bcells_Human0.79369368
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78654101
90ESR2_21235772_ChIP-Seq_MCF-7_Human0.78353648
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.78121333
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77844861
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77683650
94GATA3_24758297_ChIP-Seq_MCF-7_Human0.77300851
95SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76923039
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76575437
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75595657
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75352409
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75064054
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.74404602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.21754594
2MP0001666_abnormal_nutrient_absorption4.81832923
3MP0005085_abnormal_gallbladder_physiolo4.80131557
4MP0003183_abnormal_peptide_metabolism4.70548201
5MP0004147_increased_porphyrin_level3.76327117
6MP0005365_abnormal_bile_salt3.70621824
7MP0009379_abnormal_foot_pigmentation3.66140266
8MP0004019_abnormal_vitamin_homeostasis3.64417719
9MP0004264_abnormal_extraembryonic_tissu3.50670658
10MP0002139_abnormal_hepatobiliary_system3.48783363
11MP0009840_abnormal_foam_cell3.18781774
12MP0010155_abnormal_intestine_physiology2.78470846
13MP0010234_abnormal_vibrissa_follicle2.70683006
14MP0005409_darkened_coat_color2.27657927
15MP0010329_abnormal_lipoprotein_level2.07653096
16MP0003866_abnormal_defecation2.06058353
17MP0001664_abnormal_digestion2.01281663
18MP0003868_abnormal_feces_composition1.86041599
19MP0005332_abnormal_amino_acid1.84424753
20MP0009643_abnormal_urine_homeostasis1.79833795
21MP0000490_abnormal_crypts_of1.74507478
22MP0010352_gastrointestinal_tract_polyps1.65618544
23MP0000538_abnormal_urinary_bladder1.63891655
24MP0003252_abnormal_bile_duct1.60696077
25MP0001764_abnormal_homeostasis1.56733121
26MP0005166_decreased_susceptibility_to1.55932053
27MP0000477_abnormal_intestine_morphology1.44023740
28MP0001188_hyperpigmentation1.43160007
29MP0003806_abnormal_nucleotide_metabolis1.43147840
30MP0005670_abnormal_white_adipose1.42850193
31MP0000678_abnormal_parathyroid_gland1.40471770
32MP0001765_abnormal_ion_homeostasis1.39150820
33MP0004858_abnormal_nervous_system1.31143060
34MP0001873_stomach_inflammation1.30968079
35MP0005636_abnormal_mineral_homeostasis1.28565332
36MP0002876_abnormal_thyroid_physiology1.26740635
37MP0002136_abnormal_kidney_physiology1.19313957
38MP0003718_maternal_effect1.18720208
39MP0002822_catalepsy1.18109560
40MP0001501_abnormal_sleep_pattern1.17154430
41MP0001663_abnormal_digestive_system1.15699382
42MP0004270_analgesia1.13826577
43MP0002118_abnormal_lipid_homeostasis1.13037491
44MP0004782_abnormal_surfactant_physiolog1.11398899
45MP0000462_abnormal_digestive_system1.10507967
46MP0003879_abnormal_hair_cell1.07417517
47MP0005448_abnormal_energy_balance1.03220717
48MP0005535_abnormal_body_temperature0.98135790
49MP0004043_abnormal_pH_regulation0.97790776
50MP0005381_digestive/alimentary_phenotyp0.96780540
51MP0000609_abnormal_liver_physiology0.96482450
52MP0005584_abnormal_enzyme/coenzyme_acti0.93291675
53MP0002396_abnormal_hematopoietic_system0.92859624
54MP0002971_abnormal_brown_adipose0.90086323
55MP0001756_abnormal_urination0.86834069
56MP0001845_abnormal_inflammatory_respons0.86755700
57MP0000465_gastrointestinal_hemorrhage0.84816977
58MP0000230_abnormal_systemic_arterial0.82988531
59MP0000537_abnormal_urethra_morphology0.81084078
60MP0003300_gastrointestinal_ulcer0.80622831
61MP0005451_abnormal_body_composition0.80219025
62MP0002098_abnormal_vibrissa_morphology0.77847559
63MP0009115_abnormal_fat_cell0.77793446
64MP0002166_altered_tumor_susceptibility0.76623843
65MP0005319_abnormal_enzyme/_coenzyme0.73358753
66MP0008469_abnormal_protein_level0.72718971
67MP0009785_altered_susceptibility_to0.72069750
68MP0002796_impaired_skin_barrier0.70990167
69MP0009642_abnormal_blood_homeostasis0.66889122
70MP0003724_increased_susceptibility_to0.65971977
71MP0001835_abnormal_antigen_presentation0.65649555
72MP0001485_abnormal_pinna_reflex0.64745106
73MP0005666_abnormal_adipose_tissue0.60788736
74MP0000604_amyloidosis0.58920482
75MP0003191_abnormal_cellular_cholesterol0.58785684
76MP0009764_decreased_sensitivity_to0.58413322
77MP0005025_abnormal_response_to0.58200065
78MP0000249_abnormal_blood_vessel0.57921593
79MP0006082_CNS_inflammation0.56044111
80MP0002896_abnormal_bone_mineralization0.55618755
81MP0006138_congestive_heart_failure0.55276594
82MP0005174_abnormal_tail_pigmentation0.54602327
83MP0005501_abnormal_skin_physiology0.53677485
84MP0003329_amyloid_beta_deposits0.53141074
85MP0004947_skin_inflammation0.52410192
86MP0008872_abnormal_physiological_respon0.51417108
87MP0003303_peritoneal_inflammation0.51089959
88MP0001790_abnormal_immune_system0.50689144
89MP0005387_immune_system_phenotype0.50689144
90MP0002138_abnormal_hepatobiliary_system0.50362556
91MP0003436_decreased_susceptibility_to0.49681795
92MP0005334_abnormal_fat_pad0.49234631
93MP0001881_abnormal_mammary_gland0.48784101
94MP0008875_abnormal_xenobiotic_pharmacok0.48697637
95MP0009333_abnormal_splenocyte_physiolog0.48477522
96MP0002006_tumorigenesis0.48355146
97MP0003953_abnormal_hormone_level0.46012293
98MP0000015_abnormal_ear_pigmentation0.45477066
99MP0002078_abnormal_glucose_homeostasis0.44965114
100MP0002009_preneoplasia0.40474113

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of proline metabolism (HP:0010907)7.48850083
2Hydroxyprolinuria (HP:0003080)7.48850083
3Malnutrition (HP:0004395)7.28767912
4Hypobetalipoproteinemia (HP:0003563)5.96713814
5Chronic diarrhea (HP:0002028)5.83273271
6Abnormality of the vitamin B12 metabolism (HP:0004341)5.47443350
7Acanthocytosis (HP:0001927)5.16993622
8Abnormality of vitamin B metabolism (HP:0004340)5.10981599
9Ileus (HP:0002595)5.08266994
10Fat malabsorption (HP:0002630)4.93926844
11Widely patent fontanelles and sutures (HP:0004492)4.86389658
12Confusion (HP:0001289)4.50286520
13Pigmentary retinal degeneration (HP:0001146)4.12174056
14Abnormality of vitamin metabolism (HP:0100508)4.03756991
15Hyperglycinuria (HP:0003108)3.97521595
16Thin bony cortex (HP:0002753)3.77246637
17Systemic lupus erythematosus (HP:0002725)3.76919924
18Nausea (HP:0002018)3.68706842
19Wide cranial sutures (HP:0010537)3.68622885
20Abnormality of urine glucose concentration (HP:0011016)3.68124019
21Glycosuria (HP:0003076)3.68124019
22Proximal tubulopathy (HP:0000114)3.37339695
23Abnormality of glycine metabolism (HP:0010895)3.31889338
24Abnormality of serine family amino acid metabolism (HP:0010894)3.31889338
25Abdominal distention (HP:0003270)3.22063930
26Hyperactive renin-angiotensin system (HP:0000841)3.17833286
27Potter facies (HP:0002009)3.15241082
28Facial shape deformation (HP:0011334)3.15241082
29Decreased circulating renin level (HP:0003351)3.15104913
30Steatorrhea (HP:0002570)3.03195590
31Xanthomatosis (HP:0000991)3.02253840
32Congenital sensorineural hearing impairment (HP:0008527)3.02223926
33Hyperuricemia (HP:0002149)2.97436587
34Increased purine levels (HP:0004368)2.97436587
35Alkalosis (HP:0001948)2.95504643
36Metabolic alkalosis (HP:0200114)2.94731894
37Megaloblastic anemia (HP:0001889)2.94406081
38Hypophosphatemia (HP:0002148)2.92924792
39Posterior subcapsular cataract (HP:0007787)2.91155694
40Abnormality of monocarboxylic acid metabolism (HP:0010996)2.86901803
41Hypolipoproteinemia (HP:0010981)2.85914844
42* Nephrolithiasis (HP:0000787)2.80252226
43Enlarged epiphyses (HP:0010580)2.77036745
44Hyperparathyroidism (HP:0000843)2.72272499
45Abnormality of small intestinal villus morphology (HP:0011472)2.69696501
46Villous atrophy (HP:0011473)2.69696501
47Eczematoid dermatitis (HP:0000976)2.65191175
48Abnormality of purine metabolism (HP:0004352)2.64799444
49Hyperammonemia (HP:0001987)2.64583817
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.64110610
51Abnormal urine phosphate concentration (HP:0012599)2.57636387
52Delayed epiphyseal ossification (HP:0002663)2.57293173
53Focal segmental glomerulosclerosis (HP:0000097)2.50374196
54Abnormality of renin-angiotensin system (HP:0000847)2.49826440
55Abnormal glucose tolerance (HP:0001952)2.42421839
56Hypotension (HP:0002615)2.42321498
57Abnormality of the costochondral junction (HP:0000919)2.38872016
58Right ventricular cardiomyopathy (HP:0011663)2.38664971
59Hyperphosphaturia (HP:0003109)2.36444295
60Abnormality of nucleobase metabolism (HP:0010932)2.33719533
61Hemorrhage of the eye (HP:0011885)2.29914935
62Epidermoid cyst (HP:0200040)2.23493487
63Poikilocytosis (HP:0004447)2.22775407
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.15929590
65Subcapsular cataract (HP:0000523)2.15621615
66Hyperphosphatemia (HP:0002905)2.14169932
67Metabolic acidosis (HP:0001942)2.12656229
68Protuberant abdomen (HP:0001538)2.11433359
69Gout (HP:0001997)2.10600449
70Gingivitis (HP:0000230)2.10594468
71Renal tubular acidosis (HP:0001947)2.05689788
72Gastrointestinal dysmotility (HP:0002579)2.02470856
73Cerebral palsy (HP:0100021)2.00642035
74Abnormality of glutamine family amino acid metabolism (HP:0010902)10.8040249
75Pancreatitis (HP:0001733)1.97096083
76Abnormality of sulfur amino acid metabolism (HP:0004339)1.96497054
77Abnormality of magnesium homeostasis (HP:0004921)1.93384361
78Flat acetabular roof (HP:0003180)1.89704212
79Multiple lipomas (HP:0001012)1.85135952
80Glomerulosclerosis (HP:0000096)1.84173979
81Irritability (HP:0000737)1.84133818
82Glomerulonephritis (HP:0000099)1.81625545
83Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79151094
84Dicarboxylic aciduria (HP:0003215)1.79151094
85Abnormal biliary tract morphology (HP:0012440)1.78121453
86Growth hormone excess (HP:0000845)1.77702780
87Renal tubular dysfunction (HP:0000124)1.76590255
88Conjugated hyperbilirubinemia (HP:0002908)1.75878067
89Abnormality of complement system (HP:0005339)1.73502023
90Hypocalcemia (HP:0002901)1.73324582
91Symptomatic seizures (HP:0011145)1.71725349
92Segmental peripheral demyelination/remyelination (HP:0003481)1.71408871
93Abnormal enzyme/coenzyme activity (HP:0012379)1.71006768
94Nephritis (HP:0000123)1.70991083
95Abnormality of alkaline phosphatase activity (HP:0004379)1.70327287
96Dehydration (HP:0001944)1.68987351
97Metaphyseal irregularity (HP:0003025)1.67990749
98Abnormality of pyrimidine metabolism (HP:0004353)1.65908817
99Peripheral demyelination (HP:0011096)1.64870686
100Complement deficiency (HP:0004431)1.64593501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.43946288
2MST1R4.40554520
3ERN14.40288963
4MAP3K103.59918106
5PRKG23.58908376
6RIPK13.53103915
7STK392.64371248
8EPHA22.54989167
9OXSR12.09878082
10FGFR41.93903002
11TESK21.84125227
12EPHA31.74515069
13MAP3K21.69177963
14MET1.67092581
15TYK21.64276060
16PTK61.57993504
17TNIK1.55469944
18EPHB21.51027928
19PDK21.49747291
20AKT31.49383919
21MAP3K121.46719814
22DDR21.37817330
23EPHB11.33723124
24GRK61.30176612
25MST41.25831314
26PRPF4B1.20982724
27MAP4K11.20336502
28FGFR31.16893552
29STK241.13867681
30MATK1.12072729
31RIPK41.10182272
32MYLK1.09248558
33MAP3K11.06779509
34NLK1.04023011
35EPHA41.00290939
36PIK3CA0.98107474
37MAP2K20.96433532
38LMTK20.93558627
39ERBB20.91490107
40CDC42BPA0.82602283
41PDPK10.80180800
42CASK0.78862571
43PIM10.75320515
44BMPR20.74661660
45FER0.73324862
46TESK10.72734418
47PRKAA20.72435314
48MAPK110.68762837
49TAOK10.68381196
50IRAK10.63660807
51DYRK1B0.62912056
52MAP3K110.61133089
53JAK10.59939708
54MAP2K60.59836400
55PDK10.59167413
56PRKCA0.56937493
57PDGFRA0.55528938
58PRKCZ0.55253860
59YES10.50853020
60RET0.49028749
61* PRKACG0.48421984
62SRC0.46081943
63FYN0.44315815
64JAK20.42908438
65KSR20.42624165
66CAMK2D0.40783698
67CSK0.40757652
68ITK0.40435124
69TBK10.39755411
70PRKCD0.39550856
71PTK20.39036287
72CDK60.38514945
73BTK0.38325792
74PAK40.38273317
75CSF1R0.38086261
76MAP3K30.37444863
77IKBKE0.34689314
78TEC0.34219138
79MELK0.33792840
80CDK190.33714816
81MAP3K140.31525276
82SYK0.30845381
83NEK60.30805005
84ABL20.30782518
85CAMK2G0.30090172
86CAMK2B0.29088860
87GRK10.26135024
88PIK3CG0.26063189
89ZAP700.25127172
90JAK30.24330823
91BMX0.23588205
92MAPKAPK20.21901740
93LYN0.20091637
94LCK0.20050846
95IGF1R0.19227583
96KIT0.16506073
97IRAK40.15754731
98DAPK20.15704055
99MAP3K80.15452285
100RPS6KA20.15025041

Predicted pathways (KEGG)

RankGene SetZ-score
1Influenza A_Homo sapiens_hsa051648.61984188
2Cyanoamino acid metabolism_Homo sapiens_hsa004605.26299063
3Vitamin digestion and absorption_Homo sapiens_hsa049774.73440443
4Fat digestion and absorption_Homo sapiens_hsa049754.42366874
5Renin-angiotensin system_Homo sapiens_hsa046144.42209529
6Protein digestion and absorption_Homo sapiens_hsa049742.80074315
7Mineral absorption_Homo sapiens_hsa049782.66869113
8Caffeine metabolism_Homo sapiens_hsa002322.52894356
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.40174126
10Histidine metabolism_Homo sapiens_hsa003402.32956433
11Arginine biosynthesis_Homo sapiens_hsa002202.29404467
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22088707
13* Starch and sucrose metabolism_Homo sapiens_hsa005002.08201897
14Fructose and mannose metabolism_Homo sapiens_hsa000511.97576404
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.93530530
16Linoleic acid metabolism_Homo sapiens_hsa005911.92797105
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87228037
18Chemical carcinogenesis_Homo sapiens_hsa052041.86681204
19Retinol metabolism_Homo sapiens_hsa008301.86150020
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79329424
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76052396
22PPAR signaling pathway_Homo sapiens_hsa033201.74744014
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69550212
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67267497
25Bile secretion_Homo sapiens_hsa049761.65955225
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65059724
27* Carbohydrate digestion and absorption_Homo sapiens_hsa049731.64872836
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.45433415
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.44998971
30Sulfur metabolism_Homo sapiens_hsa009201.39722544
31Arachidonic acid metabolism_Homo sapiens_hsa005901.36422635
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36087193
33Arginine and proline metabolism_Homo sapiens_hsa003301.31727600
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25577130
35Glycerolipid metabolism_Homo sapiens_hsa005611.25261935
36* Galactose metabolism_Homo sapiens_hsa000521.20416259
37Tryptophan metabolism_Homo sapiens_hsa003801.11834512
38Asthma_Homo sapiens_hsa053101.09157326
39Fatty acid degradation_Homo sapiens_hsa000711.08563037
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.02654676
41Ether lipid metabolism_Homo sapiens_hsa005651.02618167
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96179930
43Phenylalanine metabolism_Homo sapiens_hsa003600.94072565
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93266456
45Allograft rejection_Homo sapiens_hsa053300.80850790
46Autoimmune thyroid disease_Homo sapiens_hsa053200.74987215
47Sphingolipid metabolism_Homo sapiens_hsa006000.74840019
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71923689
49Pancreatic secretion_Homo sapiens_hsa049720.71440494
50Graft-versus-host disease_Homo sapiens_hsa053320.71383976
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66859558
52Glutathione metabolism_Homo sapiens_hsa004800.63078506
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.61483963
54Staphylococcus aureus infection_Homo sapiens_hsa051500.58698380
55Type I diabetes mellitus_Homo sapiens_hsa049400.53408631
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53093274
57Fatty acid biosynthesis_Homo sapiens_hsa000610.48613217
58Renin secretion_Homo sapiens_hsa049240.48539195
59Fatty acid metabolism_Homo sapiens_hsa012120.47799278
60Peroxisome_Homo sapiens_hsa041460.43097925
61Folate biosynthesis_Homo sapiens_hsa007900.41611343
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38299126
63Pentose phosphate pathway_Homo sapiens_hsa000300.37013699
64Insulin resistance_Homo sapiens_hsa049310.35342711
65Antigen processing and presentation_Homo sapiens_hsa046120.35190843
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.34547342
67Tyrosine metabolism_Homo sapiens_hsa003500.34103521
68Other glycan degradation_Homo sapiens_hsa005110.33623531
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32578614
70ABC transporters_Homo sapiens_hsa020100.32513967
71Thyroid hormone synthesis_Homo sapiens_hsa049180.30512735
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30160182
73Leishmaniasis_Homo sapiens_hsa051400.28712002
74Cocaine addiction_Homo sapiens_hsa050300.24360328
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23831622
76Hepatitis C_Homo sapiens_hsa051600.18856236
77Biosynthesis of amino acids_Homo sapiens_hsa012300.18186675
78Glucagon signaling pathway_Homo sapiens_hsa049220.17359082
79Viral myocarditis_Homo sapiens_hsa054160.14332450
80* Metabolic pathways_Homo sapiens_hsa011000.14266553
81Carbon metabolism_Homo sapiens_hsa012000.14098242
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.12440905
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.12127256
84Insulin secretion_Homo sapiens_hsa049110.11224263
85Pertussis_Homo sapiens_hsa051330.11149970
86Serotonergic synapse_Homo sapiens_hsa047260.10779277
87Toxoplasmosis_Homo sapiens_hsa051450.10726109
88Hematopoietic cell lineage_Homo sapiens_hsa046400.10107622
89Tight junction_Homo sapiens_hsa045300.09663988
90Amphetamine addiction_Homo sapiens_hsa050310.09280146
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.08133482
92GnRH signaling pathway_Homo sapiens_hsa049120.07114241
93Sulfur relay system_Homo sapiens_hsa041220.06880901
94Pyruvate metabolism_Homo sapiens_hsa006200.06175895
95African trypanosomiasis_Homo sapiens_hsa051430.05860963
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.05728642
97Chemokine signaling pathway_Homo sapiens_hsa040620.01957002
98Gap junction_Homo sapiens_hsa045400.01351532
99AMPK signaling pathway_Homo sapiens_hsa041520.01302040
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.00997230

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