SIAE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.69863167
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.69863167
3L-phenylalanine metabolic process (GO:0006558)6.42325569
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.42325569
5regulation of somitogenesis (GO:0014807)6.41952180
6plasma membrane repair (GO:0001778)6.07103858
7aromatic amino acid family catabolic process (GO:0009074)6.04045659
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.87869553
9alpha-linolenic acid metabolic process (GO:0036109)5.63178597
10hair cycle (GO:0042633)5.56398627
11molting cycle (GO:0042303)5.56398627
12indole-containing compound catabolic process (GO:0042436)5.49096340
13indolalkylamine catabolic process (GO:0046218)5.49096340
14tryptophan catabolic process (GO:0006569)5.49096340
15bile acid biosynthetic process (GO:0006699)5.38817470
16bundle of His cell to Purkinje myocyte communication (GO:0086069)5.34594767
17kynurenine metabolic process (GO:0070189)5.33310933
18tryptophan metabolic process (GO:0006568)5.16809169
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.14798557
20sulfur amino acid catabolic process (GO:0000098)5.08521498
21high-density lipoprotein particle remodeling (GO:0034375)5.05539896
22detection of molecule of bacterial origin (GO:0032490)5.04048055
23urea cycle (GO:0000050)5.01604879
24urea metabolic process (GO:0019627)5.01604879
25cysteine metabolic process (GO:0006534)4.97729321
26peptidyl-glutamic acid carboxylation (GO:0017187)4.96550340
27protein carboxylation (GO:0018214)4.96550340
28glyoxylate metabolic process (GO:0046487)4.96002915
29reverse cholesterol transport (GO:0043691)4.82748763
30complement activation, alternative pathway (GO:0006957)4.81429678
31regulation of protein activation cascade (GO:2000257)4.81334019
32positive regulation of digestive system process (GO:0060456)4.69552711
33sulfation (GO:0051923)4.65508976
34bile acid metabolic process (GO:0008206)4.64133944
35negative regulation of fibrinolysis (GO:0051918)4.60210683
36regulation of triglyceride catabolic process (GO:0010896)4.58545450
37regulation of cholesterol esterification (GO:0010872)4.57019531
38nitrogen cycle metabolic process (GO:0071941)4.53943947
39replicative senescence (GO:0090399)4.52606576
40lysine catabolic process (GO:0006554)4.52346538
41lysine metabolic process (GO:0006553)4.52346538
42regulation of fibrinolysis (GO:0051917)4.51907928
43regulation of complement activation (GO:0030449)4.51747102
44plasma lipoprotein particle remodeling (GO:0034369)4.45149646
45protein-lipid complex remodeling (GO:0034368)4.45149646
46macromolecular complex remodeling (GO:0034367)4.45149646
47amino-acid betaine metabolic process (GO:0006577)4.41162743
48phospholipid efflux (GO:0033700)4.39630581
49regulation of DNA damage checkpoint (GO:2000001)4.37636677
50serine family amino acid catabolic process (GO:0009071)4.37425282
51aromatic amino acid family metabolic process (GO:0009072)4.31348714
52homocysteine metabolic process (GO:0050667)4.24741093
53tyrosine metabolic process (GO:0006570)4.21047879
54positive regulation of systemic arterial blood pressure (GO:0003084)4.20975285
55protein prenylation (GO:0018342)4.20511606
56prenylation (GO:0097354)4.20511606
57alpha-amino acid catabolic process (GO:1901606)4.19171861
58extracellular matrix assembly (GO:0085029)4.16844291
59cellular ketone body metabolic process (GO:0046950)4.10147231
60cholesterol efflux (GO:0033344)4.06651321
61negative regulation of systemic arterial blood pressure (GO:0003085)4.05502393
62ethanol oxidation (GO:0006069)4.04570146
63negative regulation of sterol transport (GO:0032372)4.02850653
64negative regulation of cholesterol transport (GO:0032375)4.02850653
65acylglycerol homeostasis (GO:0055090)3.98198938
66triglyceride homeostasis (GO:0070328)3.98198938
67low-density lipoprotein particle remodeling (GO:0034374)3.97833238
68bile acid and bile salt transport (GO:0015721)3.97524951
69plasma lipoprotein particle assembly (GO:0034377)3.95196260
70T cell mediated immunity (GO:0002456)3.95004295
71indolalkylamine metabolic process (GO:0006586)3.93761971
72plasma lipoprotein particle clearance (GO:0034381)3.92488357
73cellular amino acid catabolic process (GO:0009063)3.89675020
74glycine metabolic process (GO:0006544)3.87938442
75imidazole-containing compound metabolic process (GO:0052803)3.85990330
76positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.85186505
77glutamate metabolic process (GO:0006536)3.85040977
78coenzyme catabolic process (GO:0009109)3.84112150
79drug transmembrane transport (GO:0006855)3.83361938
80short-chain fatty acid metabolic process (GO:0046459)3.80796535
81dicarboxylic acid biosynthetic process (GO:0043650)3.76199248
82positive regulation of cAMP-mediated signaling (GO:0043950)3.76161921
83cellular modified amino acid catabolic process (GO:0042219)3.75333155
84desmosome organization (GO:0002934)3.75317837
85serine family amino acid biosynthetic process (GO:0009070)3.74295804
86cellular biogenic amine catabolic process (GO:0042402)3.74038781
87amine catabolic process (GO:0009310)3.74038781
88negative regulation of peptidyl-lysine acetylation (GO:2000757)3.72711613
89serine family amino acid metabolic process (GO:0009069)3.71540462
90very-low-density lipoprotein particle assembly (GO:0034379)3.69976161
91positive regulation of cardiac muscle cell differentiation (GO:2000727)3.69370305
92blood coagulation, intrinsic pathway (GO:0007597)3.68299972
93microglial cell activation (GO:0001774)3.67988880
94benzene-containing compound metabolic process (GO:0042537)3.67870263
95peristalsis (GO:0030432)3.66239997
96positive regulation by symbiont of host defense response (GO:0052509)3.65178539
97modulation by symbiont of host defense response (GO:0052031)3.65178539
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.65178539
99modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.65178539
100positive regulation by organism of defense response of other organism involved in symbiotic interact3.65178539
101modulation by symbiont of host immune response (GO:0052553)3.65178539
102flavonoid metabolic process (GO:0009812)3.62048997
1032-oxoglutarate metabolic process (GO:0006103)3.61905081
104aldehyde catabolic process (GO:0046185)3.61531525
105fatty acid beta-oxidation (GO:0006635)3.60816910
106phospholipid homeostasis (GO:0055091)3.60503998
107cellular glucuronidation (GO:0052695)3.59356125
108carboxylic acid catabolic process (GO:0046395)3.58807120
109organic acid catabolic process (GO:0016054)3.58807120
110fatty acid oxidation (GO:0019395)3.56033785
111cofactor catabolic process (GO:0051187)3.56016573
112cerebellar Purkinje cell differentiation (GO:0021702)3.55949392
113plasma lipoprotein particle organization (GO:0071827)3.55685747
114drug catabolic process (GO:0042737)3.55450903
115protein activation cascade (GO:0072376)3.55267455
116monocarboxylic acid catabolic process (GO:0072329)3.54415309
117fibrinolysis (GO:0042730)3.54257606
118ketone body metabolic process (GO:1902224)3.53739950
119complement activation, classical pathway (GO:0006958)3.53507839
120complement activation (GO:0006956)3.52723100
121fatty acid catabolic process (GO:0009062)3.51513169
122lipid oxidation (GO:0034440)3.51190582
123carnitine metabolic process (GO:0009437)3.50078153
124arginine metabolic process (GO:0006525)3.47220087
125drug transport (GO:0015893)3.46535976
126protein-lipid complex assembly (GO:0065005)3.46314845
127cholesterol homeostasis (GO:0042632)3.41277530
128pyridine nucleotide biosynthetic process (GO:0019363)3.41275962
129nicotinamide nucleotide biosynthetic process (GO:0019359)3.41275962
130positive regulation of triglyceride lipase activity (GO:0061365)3.38967653
131positive regulation of lipoprotein lipase activity (GO:0051006)3.38967653
132regulation of cell proliferation involved in kidney development (GO:1901722)3.36113970
133cardiac muscle adaptation (GO:0014887)3.33032033
134cardiac muscle hypertrophy in response to stress (GO:0014898)3.33032033
135muscle hypertrophy in response to stress (GO:0003299)3.33032033
136striated muscle atrophy (GO:0014891)3.31048043
137labyrinthine layer development (GO:0060711)3.26925558
138positive regulation of fatty acid beta-oxidation (GO:0032000)3.26924210
139hemidesmosome assembly (GO:0031581)3.23056721
140regulation of cardiac muscle cell contraction (GO:0086004)3.20397994
141adrenergic receptor signaling pathway (GO:0071875)3.18230066
142negative regulation of multicellular organism growth (GO:0040015)3.13477357
143leukotriene biosynthetic process (GO:0019370)3.10567715
144purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.09213022
1453-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.09213022
146striated muscle adaptation (GO:0014888)3.07388126
147positive regulation of heart rate (GO:0010460)3.03150196
148positive regulation of cardiac muscle hypertrophy (GO:0010613)2.99956729
149positive regulation of muscle hypertrophy (GO:0014742)2.99956729
150positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96622178
151negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.84287207
152hematopoietic stem cell proliferation (GO:0071425)2.83029436
153growth hormone receptor signaling pathway (GO:0060396)2.82841502
154cardiac muscle hypertrophy (GO:0003300)2.81396070
155regulation of actin filament-based movement (GO:1903115)2.80671733
156carbohydrate phosphorylation (GO:0046835)2.77260824
157post-anal tail morphogenesis (GO:0036342)2.72491632
158positive regulation of fatty acid oxidation (GO:0046321)2.71717269
159regulation of hippo signaling (GO:0035330)2.68822877
160muscle atrophy (GO:0014889)2.67442242
161striated muscle hypertrophy (GO:0014897)2.65360810
162negative regulation of protein acetylation (GO:1901984)2.65039072
163forebrain neuron development (GO:0021884)2.64423916
164regulation of phospholipid biosynthetic process (GO:0071071)2.61872674
165negative regulation of platelet activation (GO:0010544)2.61623344
166macrophage activation involved in immune response (GO:0002281)2.61516317
167sequestering of extracellular ligand from receptor (GO:0035581)2.60942620
168cellular response to growth hormone stimulus (GO:0071378)2.60345922
169CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.57150872
170T-helper cell differentiation (GO:0042093)2.57150872
171negative regulation of fatty acid transport (GO:2000192)2.57064518
172endocardial cushion development (GO:0003197)2.56142451
173regulation of fatty acid beta-oxidation (GO:0031998)2.55512585
174dermatan sulfate biosynthetic process (GO:0030208)2.52446161
175cell differentiation involved in embryonic placenta development (GO:0060706)2.50987901
176negative regulation of protein localization to cell surface (GO:2000009)2.50838448
177positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.50137676
178activation of protein kinase A activity (GO:0034199)2.49978027
179response to host immune response (GO:0052572)2.49072193
180response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.49072193
181negative regulation of smooth muscle contraction (GO:0045986)2.48885244
182macrophage activation (GO:0042116)2.48172251
183embryonic camera-type eye morphogenesis (GO:0048596)2.48118811
184regulation of metalloenzyme activity (GO:0048552)2.45501734
185pyrimidine dimer repair (GO:0006290)2.45326554
186skeletal muscle adaptation (GO:0043501)2.43878610
187dopamine transport (GO:0015872)2.43596410
188regulation of sequestering of triglyceride (GO:0010889)2.43192856
189regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42086894
190regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.39365014
191regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.39191478
192positive regulation of insulin receptor signaling pathway (GO:0046628)2.36891377
193regulation of digestive system process (GO:0044058)2.35044959
194extracellular fibril organization (GO:0043206)2.34837677
195activation of JUN kinase activity (GO:0007257)2.34506120
196fibril organization (GO:0097435)2.34368215
197regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.33039682
198negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.32700799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.09418609
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.43964264
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.36211716
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.28371473
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.78119979
6STAT6_21828071_ChIP-Seq_BEAS2B_Human5.33077345
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.94720481
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.64516597
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.51046261
10GATA1_22025678_ChIP-Seq_K562_Human4.04079394
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.01054223
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.88100418
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.31413040
14IRF8_22096565_ChIP-ChIP_GC-B_Human3.08049068
15TP53_16413492_ChIP-PET_HCT116_Human3.02823658
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97889772
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.15273630
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13384910
19AHR_22903824_ChIP-Seq_MCF-7_Human2.10463305
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02639972
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5505918
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.97993291
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93110482
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92207037
25SCL_19346495_ChIP-Seq_HPC-7_Human1.80237814
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.80008765
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.71337671
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.68607406
29VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.63621330
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62957938
31AR_21572438_ChIP-Seq_LNCaP_Human1.62175970
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61892151
33ARNT_22903824_ChIP-Seq_MCF-7_Human1.58702269
34EZH2_22144423_ChIP-Seq_EOC_Human1.57903426
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57597628
36DROSHA_22980978_ChIP-Seq_HELA_Human1.51729903
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48342520
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47513727
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47242740
40HTT_18923047_ChIP-ChIP_STHdh_Human1.46499291
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45222742
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44802331
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.44034432
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42322167
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41431967
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.39615408
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38952339
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38503002
49CLOCK_20551151_ChIP-Seq_293T_Human1.38414138
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37443548
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.36728224
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35275971
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31401007
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.31326054
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30941125
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29209115
57CJUN_26792858_Chip-Seq_BT549_Human1.28629624
58HNF4A_19822575_ChIP-Seq_HepG2_Human1.27375946
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.27025477
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26252320
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25963942
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23964323
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22060282
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19310988
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17590664
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17412576
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.16909577
68GBX2_23144817_ChIP-Seq_PC3_Human1.16427237
69SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13752783
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12804154
71RXR_22108803_ChIP-Seq_LS180_Human1.12111117
72TP53_18474530_ChIP-ChIP_U2OS_Human1.10880890
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10151768
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.09874526
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08449570
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.07265630
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05917358
78SMAD3_21741376_ChIP-Seq_HESCs_Human1.05011934
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04566852
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04566852
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04038509
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03045465
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.02235779
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.01851638
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01561021
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00941241
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99357034
88FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98857510
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97570262
90RUNX1_27514584_Chip-Seq_MCF-7_Human0.94083339
91GF1_26923725_Chip-Seq_HPCs_Mouse0.93066323
92KLF5_25053715_ChIP-Seq_YYC3_Human0.92772501
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91996716
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91881669
95CBX2_27304074_Chip-Seq_ESCs_Mouse0.91860469
96GATA1_19941826_ChIP-Seq_K562_Human0.90593954
97* GATA2_19941826_ChIP-Seq_K562_Human0.90258612
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89697190
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89447233
100EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89440129
101RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89440129
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88718277
103TP63_23658742_ChIP-Seq_EP156T_Human0.88079266
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87811927
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87811927
106GATA4_25053715_ChIP-Seq_YYC3_Human0.86508341
107SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86175548
108LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86083345
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85768575
110* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85512347
111SMAD4_21799915_ChIP-Seq_A2780_Human0.85251340
112OCT1_27270436_Chip-Seq_PROSTATE_Human0.84314486
113RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84196357
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83368540
115JARID2_20064375_ChIP-Seq_MESCs_Mouse0.82072113
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81817500
117CBP_20019798_ChIP-Seq_JUKART_Human0.81817500
118STAT3_23295773_ChIP-Seq_U87_Human0.81215707
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81213699
120LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80995332
121MTF2_20144788_ChIP-Seq_MESCs_Mouse0.80395308
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80154074
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79838441
124TAF15_26573619_Chip-Seq_HEK293_Human0.79768104
125SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.77935013
126BRD4_27068464_Chip-Seq_AML-cells_Mouse0.77403764
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.77350923
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77276681
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.77215610
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.76878460
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76862207
132ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76853770
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.76556850
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75454051
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74993150
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74156027
137GATA2_22383799_ChIP-Seq_G1ME_Mouse0.71021022
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70627539
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70367026
140CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70134189
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.68405683
142AR_20517297_ChIP-Seq_VCAP_Human0.68315258
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.66852681
144GATA2_21666600_ChIP-Seq_HMVEC_Human0.66447073
145PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.66030137
146STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.65775918
147SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.65678265
148PU_27001747_Chip-Seq_BMDM_Mouse0.62738887
149CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.62408122
150* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.61324097
151AUTS2_25519132_ChIP-Seq_293T-REX_Human0.59959309
152GATA3_26560356_Chip-Seq_TH2_Human0.59809702
153GATA3_26560356_Chip-Seq_TH1_Human0.58641952
154ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.56646351
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.55886840
156* SOX2_20726797_ChIP-Seq_SW620_Human0.55342819
157BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54269694
158PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.53028571
159STAT1_17558387_ChIP-Seq_HELA_Human0.52921760
160GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.52090563
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.52029903
162CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.51939082
163CDX2_20551321_ChIP-Seq_CACO-2_Human0.50867366
164ERG_20887958_ChIP-Seq_HPC-7_Mouse0.50720560
165FOXA1_25552417_ChIP-Seq_VCAP_Human0.50480157
166CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.48942280
167E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.48349283
168EGR1_19032775_ChIP-ChIP_M12_Human0.48125150
169TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.48058672
170SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.47511367
171RARA_24833708_ChIP-Seq_LIVER_Mouse0.47346682
172CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.46984051
173RUNX_20019798_ChIP-Seq_JUKART_Human0.46910605
174FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46903267
175MYB_26560356_Chip-Seq_TH1_Human0.46888000
176SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.46800921
177SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.46444767
178IRF1_19129219_ChIP-ChIP_H3396_Human0.45982320
179ZNF263_19887448_ChIP-Seq_K562_Human0.45932388

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.54092083
2MP0005360_urolithiasis6.88101684
3MP0002163_abnormal_gland_morphology6.11412747
4MP0005085_abnormal_gallbladder_physiolo5.81272251
5MP0005365_abnormal_bile_salt5.57860023
6MP0005275_abnormal_skin_tensile5.42534726
7MP0008875_abnormal_xenobiotic_pharmacok4.81810596
8MP0008438_abnormal_cutaneous_collagen4.81405475
9MP0005171_absent_coat_pigmentation4.76881967
10MP0005379_endocrine/exocrine_gland_phen3.69673524
11MP0003806_abnormal_nucleotide_metabolis3.66041625
12MP0003252_abnormal_bile_duct3.53558268
13MP0010329_abnormal_lipoprotein_level3.48468604
14MP0009840_abnormal_foam_cell3.38486022
15MP0005083_abnormal_biliary_tract2.77114447
16MP0003195_calcinosis2.61227266
17MP0000569_abnormal_digit_pigmentation2.58706200
18MP0003191_abnormal_cellular_cholesterol2.57915367
19MP0005332_abnormal_amino_acid2.53027153
20MP0001666_abnormal_nutrient_absorption2.44196267
21MP0005503_abnormal_tendon_morphology2.43407784
22MP0002060_abnormal_skin_morphology2.33534114
23MP0003279_aneurysm2.25580880
24MP0000609_abnormal_liver_physiology2.16539777
25MP0002118_abnormal_lipid_homeostasis2.03503436
26MP0002138_abnormal_hepatobiliary_system2.01128813
27MP0003868_abnormal_feces_composition1.94617562
28MP0004019_abnormal_vitamin_homeostasis1.94054949
29MP0000613_abnormal_salivary_gland1.91305205
30MP0008057_abnormal_DNA_replication1.90431977
31MP0008872_abnormal_physiological_respon1.90058008
32MP0005319_abnormal_enzyme/_coenzyme1.79335456
33MP0001764_abnormal_homeostasis1.78885917
34MP0002332_abnormal_exercise_endurance1.75998459
35MP0001958_emphysema1.72193584
36MP0009697_abnormal_copulation1.66983642
37MP0005584_abnormal_enzyme/coenzyme_acti1.66175870
38MP0005409_darkened_coat_color1.64899537
39MP0005076_abnormal_cell_differentiation1.51820930
40MP0004185_abnormal_adipocyte_glucose1.48139853
41MP0000371_diluted_coat_color1.46351586
42MP0000003_abnormal_adipose_tissue1.46026762
43MP0004264_abnormal_extraembryonic_tissu1.44824524
44MP0002295_abnormal_pulmonary_circulatio1.44587259
45MP0000383_abnormal_hair_follicle1.44584333
46MP0003656_abnormal_erythrocyte_physiolo1.40205904
47MP0005464_abnormal_platelet_physiology1.39764759
48MP0005058_abnormal_lysosome_morphology1.35949362
49MP0002160_abnormal_reproductive_system1.34982872
50MP0009384_cardiac_valve_regurgitation1.34091923
51MP0009643_abnormal_urine_homeostasis1.32170210
52MP0008469_abnormal_protein_level1.31299479
53MP0003186_abnormal_redox_activity1.30428913
54MP0000598_abnormal_liver_morphology1.29396556
55MP0002108_abnormal_muscle_morphology1.28836425
56MP0004134_abnormal_chest_morphology1.26284072
57MP0000604_amyloidosis1.25599776
58MP0002089_abnormal_postnatal_growth/wei1.25573760
59MP0000749_muscle_degeneration1.21324670
60MP0010368_abnormal_lymphatic_system1.20805000
61MP0003724_increased_susceptibility_to1.20470869
62MP0003959_abnormal_lean_body1.15142387
63MP0002006_tumorigenesis1.14633558
64MP0005388_respiratory_system_phenotype1.13328804
65MP0002133_abnormal_respiratory_system1.13328804
66MP0000733_abnormal_muscle_development1.13088130
67MP0004381_abnormal_hair_follicle1.12894990
68MP0005375_adipose_tissue_phenotype1.12549839
69MP0009764_decreased_sensitivity_to1.09955633
70MP0005636_abnormal_mineral_homeostasis1.07352567
71MP0009763_increased_sensitivity_to1.07294673
72MP0001243_abnormal_dermal_layer1.04268099
73MP0003436_decreased_susceptibility_to1.03116799
74MP0000750_abnormal_muscle_regeneration1.02474387
75MP0009642_abnormal_blood_homeostasis1.01939538
76MP0002009_preneoplasia0.99294163
77MP0001853_heart_inflammation0.97126921
78MP0001216_abnormal_epidermal_layer0.95785643
79MP0002876_abnormal_thyroid_physiology0.94806317
80MP0006036_abnormal_mitochondrial_physio0.94304249
81MP0002933_joint_inflammation0.94200718
82MP0000767_abnormal_smooth_muscle0.94118227
83MP0002078_abnormal_glucose_homeostasis0.93404717
84MP0000372_irregular_coat_pigmentation0.93182159
85MP0003690_abnormal_glial_cell0.92922940
86MP0005647_abnormal_sex_gland0.92659935
87MP0006138_congestive_heart_failure0.92391654
88MP0001502_abnormal_circadian_rhythm0.92377456
89MP0004147_increased_porphyrin_level0.91157705
90MP0003300_gastrointestinal_ulcer0.91117754
91MP0010771_integument_phenotype0.89297295
92MP0005376_homeostasis/metabolism_phenot0.88052727
93MP0001879_abnormal_lymphatic_vessel0.87738310
94MP0004130_abnormal_muscle_cell0.87427875
95MP0000163_abnormal_cartilage_morphology0.86577547
96MP0000013_abnormal_adipose_tissue0.86535379
97MP0001835_abnormal_antigen_presentation0.86456821
98MP0002254_reproductive_system_inflammat0.86416333
99MP0001191_abnormal_skin_condition0.85890068
100MP0005084_abnormal_gallbladder_morpholo0.84912535
101MP0000747_muscle_weakness0.84584885
102MP0005389_reproductive_system_phenotype0.84198528
103MP0004142_abnormal_muscle_tone0.83492298
104MP0005535_abnormal_body_temperature0.83271259
105MP0002419_abnormal_innate_immunity0.82909406
106MP0003828_pulmonary_edema0.81198290
107MP0009785_altered_susceptibility_to0.81102126
108MP0003221_abnormal_cardiomyocyte_apopto0.81039188
109MP0005646_abnormal_pituitary_gland0.80315112
110MP0003172_abnormal_lysosome_physiology0.79789440
111MP0003453_abnormal_keratinocyte_physiol0.78689584
112MP0005023_abnormal_wound_healing0.77791156
113MP0003950_abnormal_plasma_membrane0.77396526
114MP0005334_abnormal_fat_pad0.76510021
115MP0005220_abnormal_exocrine_pancreas0.75937583
116MP0001845_abnormal_inflammatory_respons0.75060262
117MP0009765_abnormal_xenobiotic_induced0.74767712
118MP0005448_abnormal_energy_balance0.73072625
119MP0005666_abnormal_adipose_tissue0.72640135
120MP0010678_abnormal_skin_adnexa0.71799149
121MP0006276_abnormal_autonomic_nervous0.71760321
122MP0002971_abnormal_brown_adipose0.71730025
123MP0001440_abnormal_grooming_behavior0.71044371
124MP0004782_abnormal_surfactant_physiolog0.70499425
125MP0000639_abnormal_adrenal_gland0.69989708
126MP0002735_abnormal_chemical_nociception0.68666821
127MP0005025_abnormal_response_to0.67739789
128MP0004484_altered_response_of0.66422582
129MP0002269_muscular_atrophy0.65284627
130MP0003011_delayed_dark_adaptation0.64590171
131MP0005670_abnormal_white_adipose0.64361876
132MP0003638_abnormal_response/metabolism_0.64153108
133MP0010386_abnormal_urinary_bladder0.64087381
134MP0003075_altered_response_to0.63309024
135MP0005266_abnormal_metabolism0.62983065
136MP0002733_abnormal_thermal_nociception0.62650309
137MP0006082_CNS_inflammation0.60884329
138MP0001756_abnormal_urination0.59709624
139MP0002136_abnormal_kidney_physiology0.59128231
140MP0002075_abnormal_coat/hair_pigmentati0.58622107
141MP0003045_fibrosis0.58570246
142MP0005166_decreased_susceptibility_to0.58348998
143MP0005408_hypopigmentation0.58088881
144MP0005451_abnormal_body_composition0.57820932
145MP0001544_abnormal_cardiovascular_syste0.57055464
146MP0005385_cardiovascular_system_phenoty0.57055464
147MP0001661_extended_life_span0.56508195
148MP0000367_abnormal_coat/_hair0.56070254
149MP0008770_decreased_survivor_rate0.56067683
150MP0002282_abnormal_trachea_morphology0.56059092
151MP0003953_abnormal_hormone_level0.55501813
152MP0008874_decreased_physiological_sensi0.54506725
153MP0010234_abnormal_vibrissa_follicle0.54494097
154MP0005167_abnormal_blood-brain_barrier0.53980920
155MP0000762_abnormal_tongue_morphology0.53934782
156MP0005620_abnormal_muscle_contractility0.51860827
157MP0003329_amyloid_beta_deposits0.51062998
158MP0009780_abnormal_chondrocyte_physiolo0.50713254
159MP0000249_abnormal_blood_vessel0.50390783
160MP0002166_altered_tumor_susceptibility0.49406438
161MP0002928_abnormal_bile_duct0.48793877
162MP0008961_abnormal_basal_metabolism0.48685964
163MP0005423_abnormal_somatic_nervous0.48588160
164MP0009115_abnormal_fat_cell0.47374451
165MP0010155_abnormal_intestine_physiology0.47332720
166MP0000230_abnormal_systemic_arterial0.46845769
167MP0001533_abnormal_skeleton_physiology0.45598321
168* MP0002723_abnormal_immune_serum0.44317160
169MP0003943_abnormal_hepatobiliary_system0.43693768
170MP0003705_abnormal_hypodermis_morpholog0.42715163
171* MP0001800_abnormal_humoral_immune0.42711059
172MP0003183_abnormal_peptide_metabolism0.42160903
173* MP0005000_abnormal_immune_tolerance0.41739874
174MP0005075_abnormal_melanosome_morpholog0.40973044
175MP0004043_abnormal_pH_regulation0.40425339
176MP0008873_increased_physiological_sensi0.39806174
177MP0006035_abnormal_mitochondrial_morpho0.39722967

Predicted human phenotypes

RankGene SetZ-score
1Deformed sella turcica (HP:0002681)6.61378837
2Intrahepatic cholestasis (HP:0001406)6.51401204
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.39755096
4Deep venous thrombosis (HP:0002625)6.12939200
5Diastasis recti (HP:0001540)5.72830028
6Prolonged partial thromboplastin time (HP:0003645)5.67574214
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.65018596
8Broad ribs (HP:0000885)5.56313821
9J-shaped sella turcica (HP:0002680)5.55747211
10Vertebral arch anomaly (HP:0008438)5.54734879
11Hypobetalipoproteinemia (HP:0003563)5.51120946
12Xanthomatosis (HP:0000991)5.45741449
13Carpal bone hypoplasia (HP:0001498)5.38550985
14Flat acetabular roof (HP:0003180)5.36993916
15Abnormality of the sella turcica (HP:0002679)4.86029572
16Complement deficiency (HP:0004431)4.79773547
17Hyperlipoproteinemia (HP:0010980)4.70516757
18Neoplasm of the heart (HP:0100544)4.63039649
19Thoracolumbar scoliosis (HP:0002944)4.46454193
20Joint hemorrhage (HP:0005261)4.44750974
21Abnormality of glycolipid metabolism (HP:0010969)4.23992719
22Abnormality of liposaccharide metabolism (HP:0010968)4.23992719
23Abnormality of glycosphingolipid metabolism (HP:0004343)4.23992719
24Anomalous pulmonary venous return (HP:0010772)4.23739304
25Hyperammonemia (HP:0001987)4.23302405
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.15969369
27Abnormality of the odontoid process (HP:0003310)4.13806653
28Ketosis (HP:0001946)4.05472182
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.04566667
30Short 4th metacarpal (HP:0010044)4.04566667
31Aortic regurgitation (HP:0001659)3.99409261
32Hypolipoproteinemia (HP:0010981)3.99204483
33Abnormality of the common coagulation pathway (HP:0010990)3.97690630
34Hypoglycemic coma (HP:0001325)3.86895892
35Milia (HP:0001056)3.86395068
36Abnormality of the pulmonary veins (HP:0011718)3.86385316
37Hyperglycinemia (HP:0002154)3.84436853
38Fat malabsorption (HP:0002630)3.77566347
39Epidermoid cyst (HP:0200040)3.77092079
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.68646941
41Abnormality of glutamine family amino acid metabolism (HP:0010902)3.67598466
42Abnormality of sulfur amino acid metabolism (HP:0004339)3.64229579
43Genetic anticipation (HP:0003743)3.60843926
44Abnormality of the intrinsic pathway (HP:0010989)3.48969501
45Death in childhood (HP:0003819)3.48932512
46Conjugated hyperbilirubinemia (HP:0002908)3.48683819
47Abnormality of aspartate family amino acid metabolism (HP:0010899)3.48501848
48Abnormality of methionine metabolism (HP:0010901)3.47737642
49Abnormality of the lumbar spine (HP:0100712)3.46191087
50Short phalanx of the thumb (HP:0009660)3.44089017
51Abnormality of glycine metabolism (HP:0010895)3.39599972
52Abnormality of serine family amino acid metabolism (HP:0010894)3.39599972
53Abnormality of complement system (HP:0005339)3.39243766
54Hyperglycinuria (HP:0003108)3.37501810
55Hyperbilirubinemia (HP:0002904)3.37204373
56Hypoalphalipoproteinemia (HP:0003233)3.32568436
57Duplicated collecting system (HP:0000081)3.31071451
58Abnormality of pyrimidine metabolism (HP:0004353)3.30368209
59Hypercholesterolemia (HP:0003124)3.28543412
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27906799
61Hypoglycemic seizures (HP:0002173)3.25511987
62Flared iliac wings (HP:0002869)3.23398204
63Thickened calvaria (HP:0002684)3.23220838
64Oral leukoplakia (HP:0002745)3.22361954
65Broad alveolar ridges (HP:0000187)3.20601499
66Abnormality of fatty-acid metabolism (HP:0004359)3.20113603
67Ketoacidosis (HP:0001993)3.16283055
68Systemic lupus erythematosus (HP:0002725)3.15909483
69Abnormality of the renal collecting system (HP:0004742)3.11793327
70Beaking of vertebral bodies (HP:0004568)3.10031533
71Vertebral fusion (HP:0002948)2.94512078
72Hypoplasia of the odontoid process (HP:0003311)2.92385453
73Delayed CNS myelination (HP:0002188)2.89054260
74Acanthocytosis (HP:0001927)2.87922512
75Recurrent gram-negative bacterial infections (HP:0005420)2.87035691
76Abnormality of nucleobase metabolism (HP:0010932)2.84133971
77Medulloblastoma (HP:0002885)2.83751315
78Abnormality of the parietal bone (HP:0002696)2.83193943
79Slow saccadic eye movements (HP:0000514)2.82779786
80Abnormality of the 4th metacarpal (HP:0010012)2.82284368
81Hemiplegia (HP:0002301)2.79319559
82Gingival bleeding (HP:0000225)2.78077104
83Steatorrhea (HP:0002570)2.74685246
84Spontaneous abortion (HP:0005268)2.71680519
85Abnormality of the distal phalanx of the thumb (HP:0009617)2.71495209
86Abnormality of serum amino acid levels (HP:0003112)2.67409389
87Metabolic acidosis (HP:0001942)2.64446333
88Glomerulonephritis (HP:0000099)2.64189817
89Menorrhagia (HP:0000132)2.62208747
90Abnormality of purine metabolism (HP:0004352)2.61016852
91Recurrent bronchitis (HP:0002837)2.58516867
92Right ventricular cardiomyopathy (HP:0011663)2.58483669
93Tongue fasciculations (HP:0001308)2.58047995
94Generalized aminoaciduria (HP:0002909)2.57080514
95Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.55490920
96Dicarboxylic aciduria (HP:0003215)2.55354989
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55354989
98Myocardial infarction (HP:0001658)2.53306566
99Skin nodule (HP:0200036)2.50173019
100Arterial tortuosity (HP:0005116)2.45855054
101Wide intermamillary distance (HP:0006610)2.45833682
102Prominent occiput (HP:0000269)2.44690061
103Sensorimotor neuropathy (HP:0007141)2.43666554
104Hoarse voice (HP:0001609)2.43561449
105Down-sloping shoulders (HP:0200021)2.43449867
106Supernumerary ribs (HP:0005815)2.40528267
107Macroglossia (HP:0000158)2.40450124
108Spontaneous hematomas (HP:0007420)2.39007031
109Mitral stenosis (HP:0001718)2.37707453
110Muscle fibrillation (HP:0010546)2.37628801
111Hypoplastic pelvis (HP:0008839)2.36735690
112Muscle fiber splitting (HP:0003555)2.34293338
113Pathologic fracture (HP:0002756)2.34000465
114Abnormality of the thoracic spine (HP:0100711)2.31937215
115Lethargy (HP:0001254)2.28851461
116Hepatocellular carcinoma (HP:0001402)2.26774619
117Thrombophlebitis (HP:0004418)2.26117748
118Symptomatic seizures (HP:0011145)2.25516486
119Late onset (HP:0003584)2.25397512
120Gout (HP:0001997)2.25154358
121Aplasia/Hypoplasia of the scapulae (HP:0006713)2.24494465
122Hypoplastic scapulae (HP:0000882)2.24494465
123Supernumerary bones of the axial skeleton (HP:0009144)2.24302375
124Ovoid vertebral bodies (HP:0003300)2.21639453
125Hyperinsulinemic hypoglycemia (HP:0000825)2.20661305
126Vacuolated lymphocytes (HP:0001922)2.17957420
127Cholecystitis (HP:0001082)2.17906187
128Abnormal gallbladder physiology (HP:0012438)2.17906187
129Pancreatitis (HP:0001733)2.17842657
130Abnormal gallbladder morphology (HP:0012437)2.16871154
131Protuberant abdomen (HP:0001538)2.16691442
132Impaired platelet aggregation (HP:0003540)2.14961859
133Abnormal platelet function (HP:0011869)2.14961859
134Calf muscle hypertrophy (HP:0008981)2.14482694
135Vascular tortuosity (HP:0004948)2.12014542
136Increased connective tissue (HP:0009025)2.11467486
137Neoplasm of the oral cavity (HP:0100649)2.11370836
138Spastic diplegia (HP:0001264)2.11120531
139Thoracic kyphosis (HP:0002942)2.11115245
140Epistaxis (HP:0000421)2.09112751
141Esophageal varix (HP:0002040)2.07759823
142Cholelithiasis (HP:0001081)2.07696034
143Dysostosis multiplex (HP:0000943)2.06288696
144Abnormality of DNA repair (HP:0003254)2.03671281
145Cerebellar dysplasia (HP:0007033)2.03530518
146Abnormality of the wing of the ilium (HP:0011867)2.01269581
147Irritability (HP:0000737)2.00091726
148Abnormality of the alveolar ridges (HP:0006477)1.98842509
149Poikilocytosis (HP:0004447)1.97649416
150Abnormal auditory evoked potentials (HP:0006958)1.97447976
151Vascular calcification (HP:0004934)1.96932141
152Neonatal onset (HP:0003623)1.96425124
153Urinary glycosaminoglycan excretion (HP:0003541)1.95843001
154Mucopolysacchariduria (HP:0008155)1.95843001
155Opisthotonus (HP:0002179)1.95717818
156Cerebral edema (HP:0002181)1.95363132
157Hemorrhage of the eye (HP:0011885)1.95016093
158Hypoplasia of the iris (HP:0007676)1.93173971
159Amyloidosis (HP:0011034)1.90166499
160Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89644849
161Abnormality of polysaccharide metabolism (HP:0011012)1.89644849
162Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89644849
163Vomiting (HP:0002013)1.89552809
164Clumsiness (HP:0002312)1.87777629
165Abnormality of the humerus (HP:0003063)1.87407841
166Purpura (HP:0000979)1.87078851
167Brushfield spots (HP:0001088)1.86926663
168Impaired smooth pursuit (HP:0007772)1.86653447
169Abnormality of the nasal septum (HP:0000419)1.86297963
170Muscle hypertrophy of the lower extremities (HP:0008968)1.85318218
171Severe short stature (HP:0003510)1.85309040
172Progressive cerebellar ataxia (HP:0002073)1.84582107
173Neoplasm of striated muscle (HP:0009728)1.84565152
174Pulmonary embolism (HP:0002204)1.84474626
175Elevated hepatic transaminases (HP:0002910)1.83426038
176Short ribs (HP:0000773)1.82715024
177Lack of skin elasticity (HP:0100679)1.82402716
178Skin pits (HP:0100276)1.81906819
179Ureteral obstruction (HP:0006000)1.80763502
180Nephritis (HP:0000123)1.80533724
181Abnormality of proline metabolism (HP:0010907)1.78716720
182Hydroxyprolinuria (HP:0003080)1.78716720
183Abnormality of the gallbladder (HP:0005264)1.78597689
184Abnormality of the upper arm (HP:0001454)1.78249136
185Enlarged kidneys (HP:0000105)1.77984084
186Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77499430
187Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.77043239
188Abnormal hand bone ossification (HP:0010660)1.74626058
189Hypochromic microcytic anemia (HP:0004840)1.74445311
190Dry hair (HP:0011359)1.71431552
191Cavernous hemangioma (HP:0001048)1.69338558
192Palpebral edema (HP:0100540)1.68768371
193Visual hallucinations (HP:0002367)1.66901147
194Hemivertebrae (HP:0002937)1.64604770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.89752006
2KIT3.09514619
3TAOK33.07687523
4SIK13.00510180
5FLT32.99106143
6ERN12.89579305
7FGFR42.88230061
8TIE12.58980108
9NEK92.56939589
10INSRR2.44113136
11TYK22.43035376
12TLK12.11285080
13TGFBR22.07595655
14MAP3K42.00331332
15PKN21.94695918
16MAP4K11.94154808
17CSF1R1.92528850
18WNK11.79732119
19CASK1.68152324
20SCYL21.67754411
21CDK121.67474731
22TBK11.67414051
23ACVR1B1.61464851
24MAPK111.59350888
25STK41.58383146
26MAP2K41.52601646
27PIK3CG1.51074037
28CDK191.51058401
29ADRBK21.50373875
30IRAK31.47625349
31JAK11.47316718
32PRPF4B1.46340053
33PTK2B1.45682742
34TEC1.41112693
35CAMKK21.37541347
36BLK1.34316484
37DAPK21.33855498
38MAP3K61.33337824
39SGK4941.30138511
40SGK2231.30138511
41BTK1.29204028
42IRAK21.27985661
43MAPK151.27139478
44JAK21.24287977
45MATK1.20067449
46EPHA31.19705993
47MAP3K21.18685995
48AKT31.18004510
49ERBB41.17285758
50CCNB11.14230020
51MAP3K121.14048066
52MAP3K111.12884798
53CAMK1D1.09864609
54PDK41.04876417
55PDK31.04876417
56SYK1.04515176
57PBK1.03323357
58EPHA20.99097647
59DAPK30.99016693
60GRK60.95920660
61MAPKAPK50.95047271
62GRK10.94958155
63JAK30.94622378
64MAP3K140.94410984
65NUAK10.94213647
66PRKAA20.94040068
67MAP3K70.91877208
68FRK0.91543370
69ADRBK10.90094362
70MAP2K30.89922999
71MST1R0.89789182
72TRIB30.88812935
73MAP3K10.88799030
74TAOK20.87398882
75TGFBR10.87128769
76ZAK0.87021898
77PTK60.86055091
78MYLK0.84858888
79MAPK40.83486231
80GRK50.82822668
81RPS6KA50.81852911
82STK380.81679552
83DAPK10.80305271
84DYRK1B0.79980554
85SGK20.79564621
86CAMKK10.75924949
87HIPK20.75646377
88STK38L0.75181633
89ZAP700.71682673
90RPS6KA60.71447597
91PIM10.71340041
92PRKCH0.70660770
93IKBKE0.70652192
94RET0.70317556
95CAMK1G0.67927504
96LYN0.67382083
97PRKAA10.67322548
98TRPM70.65702330
99TAF10.65233023
100IRAK40.65204517
101PDGFRB0.64704884
102GRK70.59489628
103RPS6KL10.54888231
104RPS6KC10.54888231
105PDK10.54561281
106MAP2K70.54510615
107PRKACG0.53802055
108MET0.53022551
109SGK30.52318627
110MTOR0.51712611
111PRKCI0.51125645
112ERBB20.51064157
113IGF1R0.50548947
114ITK0.50162562
115LATS10.49384105
116FES0.49026505
117OBSCN0.48400173
118TNIK0.48112552
119SGK10.47199590
120KDR0.46948503
121WEE10.46197256
122BRD40.46189872
123CDK60.45915287
124PAK30.45294595
125MAP3K130.45263502
126RIPK10.45138023
127LCK0.44968417
128ICK0.44889590
129MAP3K30.44812006
130EGFR0.43704004
131EEF2K0.42182755
132MAP2K10.42131390
133BMPR1B0.41935118
134RIPK40.41745872
135MAP2K60.41578520
136NME20.40808484
137STK30.40632592
138PRKCQ0.39701288
139MAPK30.39673151
140VRK10.39654545
141CSK0.39308555
142IRAK10.38720713
143FGFR30.38494199
144KSR20.37581162
145PDPK10.36972256
146BRSK20.36643394
147SIK30.36020171
148STK100.35800767
149MST40.33717140
150TTN0.33565711
151CAMK40.32723639
152MARK20.32608684
153PHKG20.31769623
154PHKG10.31769623
155PRKD20.31705214
156CAMK10.31532612
157MAPK120.31492326
158RPS6KA20.30624203
159STK240.30219879

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.58121035
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.35771056
3Nitrogen metabolism_Homo sapiens_hsa009103.62890823
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31193455
5Alcoholism_Homo sapiens_hsa050343.27975100
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92607525
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.82200616
8Complement and coagulation cascades_Homo sapiens_hsa046102.81144241
9Arginine biosynthesis_Homo sapiens_hsa002202.74343011
10Fatty acid degradation_Homo sapiens_hsa000712.68708049
11Tryptophan metabolism_Homo sapiens_hsa003802.62299804
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46837680
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44759382
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42601686
15Caffeine metabolism_Homo sapiens_hsa002322.34956116
16Peroxisome_Homo sapiens_hsa041462.25596972
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21429353
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.07456379
19Propanoate metabolism_Homo sapiens_hsa006402.06892567
20Butanoate metabolism_Homo sapiens_hsa006502.05769119
21Staphylococcus aureus infection_Homo sapiens_hsa051502.03118533
22Histidine metabolism_Homo sapiens_hsa003401.96246478
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.94253527
24Fatty acid metabolism_Homo sapiens_hsa012121.91332304
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89265165
26PPAR signaling pathway_Homo sapiens_hsa033201.86046186
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.81237219
28Selenocompound metabolism_Homo sapiens_hsa004501.74774920
29Viral carcinogenesis_Homo sapiens_hsa052031.74470397
30Chemical carcinogenesis_Homo sapiens_hsa052041.73264445
31beta-Alanine metabolism_Homo sapiens_hsa004101.72033528
32Dorso-ventral axis formation_Homo sapiens_hsa043201.66049395
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64386097
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60997521
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.56146286
36Sulfur metabolism_Homo sapiens_hsa009201.53993420
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52984624
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52731608
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47869820
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47082325
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46522947
42Retinol metabolism_Homo sapiens_hsa008301.43384190
43Basal cell carcinoma_Homo sapiens_hsa052171.42513068
44Starch and sucrose metabolism_Homo sapiens_hsa005001.40920599
45Bile secretion_Homo sapiens_hsa049761.40518765
46Pyruvate metabolism_Homo sapiens_hsa006201.39788808
47Dilated cardiomyopathy_Homo sapiens_hsa054141.39503991
48ABC transporters_Homo sapiens_hsa020101.39103037
49Hedgehog signaling pathway_Homo sapiens_hsa043401.35166074
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.34594129
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.34580338
52Renin secretion_Homo sapiens_hsa049241.32487120
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31628781
54ECM-receptor interaction_Homo sapiens_hsa045121.31332408
55Folate biosynthesis_Homo sapiens_hsa007901.30118797
56GnRH signaling pathway_Homo sapiens_hsa049121.28623193
57Phenylalanine metabolism_Homo sapiens_hsa003601.28153876
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25813998
59Fatty acid elongation_Homo sapiens_hsa000621.20605579
60Tyrosine metabolism_Homo sapiens_hsa003501.19095606
61Gap junction_Homo sapiens_hsa045401.18886552
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.16377161
63Calcium signaling pathway_Homo sapiens_hsa040201.16321205
64Biosynthesis of amino acids_Homo sapiens_hsa012301.15729085
65Carbon metabolism_Homo sapiens_hsa012001.14247662
66Vitamin digestion and absorption_Homo sapiens_hsa049771.12427102
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10124579
68Taste transduction_Homo sapiens_hsa047421.04783076
69Cholinergic synapse_Homo sapiens_hsa047251.04767663
70Fat digestion and absorption_Homo sapiens_hsa049751.03944569
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03554825
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03182722
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01577842
74Osteoclast differentiation_Homo sapiens_hsa043800.99733023
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99592022
76FoxO signaling pathway_Homo sapiens_hsa040680.97716011
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97611289
78Type II diabetes mellitus_Homo sapiens_hsa049300.96794806
79Salivary secretion_Homo sapiens_hsa049700.96200165
80B cell receptor signaling pathway_Homo sapiens_hsa046620.95735547
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95482846
82Platelet activation_Homo sapiens_hsa046110.94055120
83MicroRNAs in cancer_Homo sapiens_hsa052060.93684395
84Prolactin signaling pathway_Homo sapiens_hsa049170.92654968
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92641846
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91854670
87One carbon pool by folate_Homo sapiens_hsa006700.91426284
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90143205
89Morphine addiction_Homo sapiens_hsa050320.89649552
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.89257804
91Focal adhesion_Homo sapiens_hsa045100.88170159
92TNF signaling pathway_Homo sapiens_hsa046680.86682000
93Renal cell carcinoma_Homo sapiens_hsa052110.85067972
94cAMP signaling pathway_Homo sapiens_hsa040240.84770148
95MAPK signaling pathway_Homo sapiens_hsa040100.83665581
96Melanoma_Homo sapiens_hsa052180.83614645
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83409196
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.83205664
99Glioma_Homo sapiens_hsa052140.81162738
100Arginine and proline metabolism_Homo sapiens_hsa003300.80567639
101ErbB signaling pathway_Homo sapiens_hsa040120.79819591
102Leishmaniasis_Homo sapiens_hsa051400.79073920
103Tuberculosis_Homo sapiens_hsa051520.78739654
104T cell receptor signaling pathway_Homo sapiens_hsa046600.78342567
105Prostate cancer_Homo sapiens_hsa052150.77772726
106Insulin secretion_Homo sapiens_hsa049110.77473209
107Glutamatergic synapse_Homo sapiens_hsa047240.77385506
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77280205
109Melanogenesis_Homo sapiens_hsa049160.76970402
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76855149
111Steroid biosynthesis_Homo sapiens_hsa001000.75904493
112Non-small cell lung cancer_Homo sapiens_hsa052230.75356109
113Choline metabolism in cancer_Homo sapiens_hsa052310.75140305
114Lysine degradation_Homo sapiens_hsa003100.72914729
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72637104
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72313426
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71458800
118Estrogen signaling pathway_Homo sapiens_hsa049150.71421728
119Circadian rhythm_Homo sapiens_hsa047100.70215296
120Glycerolipid metabolism_Homo sapiens_hsa005610.69975962
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68997810
122Small cell lung cancer_Homo sapiens_hsa052220.68609251
123VEGF signaling pathway_Homo sapiens_hsa043700.67771870
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66259737
125Gastric acid secretion_Homo sapiens_hsa049710.65770951
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.64858729
127Sulfur relay system_Homo sapiens_hsa041220.63966750
128Pathways in cancer_Homo sapiens_hsa052000.63640863
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63208326
130Inositol phosphate metabolism_Homo sapiens_hsa005620.63196463
131Oxytocin signaling pathway_Homo sapiens_hsa049210.62773278
132Protein digestion and absorption_Homo sapiens_hsa049740.60565510
133Bladder cancer_Homo sapiens_hsa052190.60555185
134Pentose phosphate pathway_Homo sapiens_hsa000300.57776796
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.57730149
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57428306
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57076228
138Fatty acid biosynthesis_Homo sapiens_hsa000610.56820207
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56667288
140Galactose metabolism_Homo sapiens_hsa000520.56251217
141Amphetamine addiction_Homo sapiens_hsa050310.55824921
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55635508
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54975196
144Malaria_Homo sapiens_hsa051440.54062487
145mTOR signaling pathway_Homo sapiens_hsa041500.54031392
146Proteoglycans in cancer_Homo sapiens_hsa052050.51408726
147GABAergic synapse_Homo sapiens_hsa047270.50859705
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50111121
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.48728101
150Glutathione metabolism_Homo sapiens_hsa004800.48576510
151Metabolic pathways_Homo sapiens_hsa011000.45712664
152Vitamin B6 metabolism_Homo sapiens_hsa007500.45339380
153Fructose and mannose metabolism_Homo sapiens_hsa000510.34037154
154Prion diseases_Homo sapiens_hsa050200.30387011
155Lysosome_Homo sapiens_hsa041420.30335773
156Adipocytokine signaling pathway_Homo sapiens_hsa049200.28794874
157Insulin resistance_Homo sapiens_hsa049310.27660595
158Other glycan degradation_Homo sapiens_hsa005110.24403530
159Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19258995
160Glucagon signaling pathway_Homo sapiens_hsa049220.15049577
161N-Glycan biosynthesis_Homo sapiens_hsa005100.06066695
162alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05454156
163Pertussis_Homo sapiens_hsa051330.03681330
164Glycerophospholipid metabolism_Homo sapiens_hsa005640.02193416
165Carbohydrate digestion and absorption_Homo sapiens_hsa049730.01529141
166Phagosome_Homo sapiens_hsa04145-0.1426279
167Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1336292
168Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1260773
169AMPK signaling pathway_Homo sapiens_hsa04152-0.1063299
170Insulin signaling pathway_Homo sapiens_hsa04910-0.1028300
171Protein export_Homo sapiens_hsa03060-0.0963827
172Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0894218
173Legionellosis_Homo sapiens_hsa05134-0.0891879
174RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0879610
175African trypanosomiasis_Homo sapiens_hsa05143-0.0862906
176Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0813507
177Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0759267
178Hepatitis C_Homo sapiens_hsa05160-0.0716252
179Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0634737
180Linoleic acid metabolism_Homo sapiens_hsa00591-0.0601076
181Renin-angiotensin system_Homo sapiens_hsa04614-0.0585499
182Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0166207

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