SIAH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of synapse maturation (GO:0090129)6.95975318
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.57517624
3synaptic vesicle exocytosis (GO:0016079)6.45967486
4vocalization behavior (GO:0071625)6.30561436
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.10723246
6layer formation in cerebral cortex (GO:0021819)6.10270948
7protein localization to synapse (GO:0035418)6.08386143
8regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.83297940
9cellular potassium ion homeostasis (GO:0030007)5.62950564
10neuron cell-cell adhesion (GO:0007158)5.59943733
11synaptic vesicle maturation (GO:0016188)5.46951165
12regulation of synapse maturation (GO:0090128)5.37041205
13nucleobase catabolic process (GO:0046113)5.32191981
14neurotransmitter-gated ion channel clustering (GO:0072578)5.30095252
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.24765404
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.14045110
17behavioral response to nicotine (GO:0035095)5.10961868
18urinary tract smooth muscle contraction (GO:0014848)5.06011746
19glutamate secretion (GO:0014047)4.99481214
20regulation of synaptic vesicle exocytosis (GO:2000300)4.70117720
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.66543708
22presynaptic membrane assembly (GO:0097105)4.56774630
23regulation of glutamate receptor signaling pathway (GO:1900449)4.55634175
24positive regulation of dendritic spine morphogenesis (GO:0061003)4.52386023
25neurotransmitter secretion (GO:0007269)4.50813596
26righting reflex (GO:0060013)4.50806745
27neuromuscular process controlling posture (GO:0050884)4.34733491
28central nervous system projection neuron axonogenesis (GO:0021952)4.25896469
29cochlea development (GO:0090102)4.24055893
30regulation of synapse structural plasticity (GO:0051823)4.21931755
31negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.20872063
32positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.18057542
33cell migration in hindbrain (GO:0021535)4.15740777
34locomotory exploration behavior (GO:0035641)4.13250648
35mating behavior (GO:0007617)4.11099354
36regulation of synaptic vesicle transport (GO:1902803)4.08274913
37synaptic vesicle endocytosis (GO:0048488)3.98747364
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.96535206
39presynaptic membrane organization (GO:0097090)3.96113112
40membrane hyperpolarization (GO:0060081)3.94937747
41cerebellar Purkinje cell differentiation (GO:0021702)3.92257573
42potassium ion homeostasis (GO:0055075)3.82245788
43neurotransmitter transport (GO:0006836)3.81343425
44startle response (GO:0001964)3.80942596
45long-term memory (GO:0007616)3.77864001
46response to auditory stimulus (GO:0010996)3.77075441
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.74528805
48mechanosensory behavior (GO:0007638)3.74519698
49regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.74049530
50synapse assembly (GO:0007416)3.72995728
51serotonin metabolic process (GO:0042428)3.69137456
52neuron recognition (GO:0008038)3.63542269
53glutamate receptor signaling pathway (GO:0007215)3.63541506
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.58893261
55neuron-neuron synaptic transmission (GO:0007270)3.58683711
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.58433439
57striatum development (GO:0021756)3.57020664
58exploration behavior (GO:0035640)3.56777546
59central nervous system neuron axonogenesis (GO:0021955)3.55850530
60detection of light stimulus involved in sensory perception (GO:0050962)3.54551491
61detection of light stimulus involved in visual perception (GO:0050908)3.54551491
62regulation of neurotransmitter levels (GO:0001505)3.50779194
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.49253409
64neuronal action potential propagation (GO:0019227)3.48963585
65positive regulation of membrane potential (GO:0045838)3.48802457
66regulation of neuronal synaptic plasticity (GO:0048168)3.48192102
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.45884804
68retinal rod cell development (GO:0046548)3.45753444
69response to histamine (GO:0034776)3.45640799
70synaptic vesicle transport (GO:0048489)3.41573547
71establishment of synaptic vesicle localization (GO:0097480)3.41573547
72limb bud formation (GO:0060174)3.40859803
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.40573033
74protein localization to cilium (GO:0061512)3.39628537
75regulation of postsynaptic membrane potential (GO:0060078)3.39026022
76ionotropic glutamate receptor signaling pathway (GO:0035235)3.38887010
77auditory behavior (GO:0031223)3.37756179
78postsynaptic membrane organization (GO:0001941)3.37190962
79regulation of respiratory system process (GO:0044065)3.36736087
80neuronal action potential (GO:0019228)3.36177467
81cilium or flagellum-dependent cell motility (GO:0001539)3.36158428
82peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.35006969
83regulation of vesicle fusion (GO:0031338)3.34092930
84innervation (GO:0060384)3.33243859
85sodium ion export (GO:0071436)3.33081683
86positive regulation of potassium ion transmembrane transport (GO:1901381)3.32917891
87cerebral cortex radially oriented cell migration (GO:0021799)3.31574791
88nonmotile primary cilium assembly (GO:0035058)3.29857244
89regulation of long-term neuronal synaptic plasticity (GO:0048169)3.25687207
90regulation of transmission of nerve impulse (GO:0051969)3.24689247
91synaptic transmission, glutamatergic (GO:0035249)3.22210504
92reflex (GO:0060004)3.21089543
93positive regulation of dendritic spine development (GO:0060999)3.20322614
94regulation of excitatory postsynaptic membrane potential (GO:0060079)3.15500287
95dendritic spine morphogenesis (GO:0060997)3.14623628
96short-term memory (GO:0007614)3.13537460
97gamma-aminobutyric acid transport (GO:0015812)3.13442014
98cell differentiation in hindbrain (GO:0021533)3.13288831
99behavioral response to cocaine (GO:0048148)3.12320199
100regulation of dendritic spine morphogenesis (GO:0061001)3.12044816
101cerebellar granule cell differentiation (GO:0021707)3.11337472
102retinal ganglion cell axon guidance (GO:0031290)3.11268916
103transmission of nerve impulse (GO:0019226)3.11034440
104neural tube formation (GO:0001841)3.10153815
105prepulse inhibition (GO:0060134)3.09948425
106regulation of dopamine metabolic process (GO:0042053)3.09633844
107regulation of catecholamine metabolic process (GO:0042069)3.09633844
108intraspecies interaction between organisms (GO:0051703)3.08867417
109social behavior (GO:0035176)3.08867417
110primary amino compound metabolic process (GO:1901160)3.07432726
111catecholamine transport (GO:0051937)3.06660469
112negative regulation of microtubule polymerization (GO:0031115)3.06315008
113long-term synaptic potentiation (GO:0060291)3.06220875
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05885623
115membrane repolarization (GO:0086009)3.05627707
116proline transport (GO:0015824)3.01861813
117synapse organization (GO:0050808)3.01793723
118regulation of cilium movement (GO:0003352)3.01231130
119response to pheromone (GO:0019236)3.00565054
120cell communication by electrical coupling (GO:0010644)2.99055776
121pyrimidine nucleobase catabolic process (GO:0006208)2.98235081
122axon cargo transport (GO:0008088)2.97749305
123dendrite morphogenesis (GO:0048813)2.97535303
124retinal cone cell development (GO:0046549)2.96891648
125negative regulation of neurological system process (GO:0031645)2.94157398
126glycosphingolipid biosynthetic process (GO:0006688)2.92458756
127adult walking behavior (GO:0007628)2.91830637
128resolution of meiotic recombination intermediates (GO:0000712)2.90135956
129epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88704559
130indolalkylamine metabolic process (GO:0006586)2.88523205
131protein polyglutamylation (GO:0018095)2.82525709
132regulation of telomere maintenance (GO:0032204)2.77813846
133positive regulation of amino acid transport (GO:0051957)2.76255192
134inner ear receptor stereocilium organization (GO:0060122)2.76066817
135positive regulation of oligodendrocyte differentiation (GO:0048714)2.75222368
136positive regulation of neurological system process (GO:0031646)2.75037924
137epithelial cilium movement (GO:0003351)2.74855332
138membrane depolarization during action potential (GO:0086010)2.74778517
139spinal cord motor neuron differentiation (GO:0021522)2.73879194
140cilium organization (GO:0044782)2.73766711
141cilium morphogenesis (GO:0060271)2.72646828
142hippocampus development (GO:0021766)2.72421278
143negative regulation of transcription regulatory region DNA binding (GO:2000678)2.70931197
144cilium assembly (GO:0042384)2.69651071
145axonal fasciculation (GO:0007413)2.68560377
146microtubule depolymerization (GO:0007019)2.67622253
147cilium movement (GO:0003341)2.66658680
148axoneme assembly (GO:0035082)2.64571867
149cornea development in camera-type eye (GO:0061303)2.64409640
150fucose catabolic process (GO:0019317)2.64266725
151L-fucose metabolic process (GO:0042354)2.64266725
152L-fucose catabolic process (GO:0042355)2.64266725
153behavioral response to ethanol (GO:0048149)2.64071252
154positive regulation of synapse assembly (GO:0051965)2.62417550
155photoreceptor cell development (GO:0042461)2.57765382
156establishment of mitochondrion localization (GO:0051654)2.56659430
157kynurenine metabolic process (GO:0070189)2.55949291
158dendrite development (GO:0016358)2.54027995
159adult behavior (GO:0030534)2.53801065
160seminiferous tubule development (GO:0072520)2.51105132
161heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.50899050
162negative regulation of telomere maintenance (GO:0032205)2.50724053
163establishment of protein localization to Golgi (GO:0072600)2.48083964
164regulation of dopamine secretion (GO:0014059)2.46862471
165axonogenesis (GO:0007409)2.46666169
166tryptophan metabolic process (GO:0006568)2.46625293
167calcium ion import (GO:0070509)2.46403944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.90280796
2GBX2_23144817_ChIP-Seq_PC3_Human4.23781748
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.44730738
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.22957541
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15187208
6REST_21632747_ChIP-Seq_MESCs_Mouse3.00438778
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98311867
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72889485
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72889485
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.69631382
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69238034
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60641931
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.52398711
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.51714848
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47222306
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.47077415
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45680907
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.44338940
19DROSHA_22980978_ChIP-Seq_HELA_Human2.42745715
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40452675
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40201502
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.39254976
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39069165
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.30035288
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.29425625
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24133218
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15757499
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.15204202
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12221269
30EWS_26573619_Chip-Seq_HEK293_Human2.07147624
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05235862
32TAF15_26573619_Chip-Seq_HEK293_Human2.01148761
33AR_21572438_ChIP-Seq_LNCaP_Human2.00619402
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98177909
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84977426
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81515117
37ZNF274_21170338_ChIP-Seq_K562_Hela1.80392434
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.76919226
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76086482
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74433690
41SMAD4_21799915_ChIP-Seq_A2780_Human1.73618769
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67350159
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63058605
44IGF1R_20145208_ChIP-Seq_DFB_Human1.60584798
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56791582
46P300_19829295_ChIP-Seq_ESCs_Human1.56090534
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55877907
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52430231
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51883416
50RNF2_27304074_Chip-Seq_NSC_Mouse1.50758557
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49447884
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.47236199
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.43692689
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43072816
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43000333
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.42811084
57AR_25329375_ChIP-Seq_VCAP_Human1.42579011
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.40700510
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38874529
60RUNX2_22187159_ChIP-Seq_PCA_Human1.34228265
61IRF1_19129219_ChIP-ChIP_H3396_Human1.34082509
62* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33796123
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.32753828
64* STAT3_23295773_ChIP-Seq_U87_Human1.30145401
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29416976
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29061006
67TP53_22573176_ChIP-Seq_HFKS_Human1.27507949
68* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27352575
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.26956609
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26847452
71AR_19668381_ChIP-Seq_PC3_Human1.26387273
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25273764
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.25040403
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23450770
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23164048
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22467409
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22231785
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20761252
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19428742
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18605219
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17956810
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.16872083
83FUS_26573619_Chip-Seq_HEK293_Human1.14935846
84* KDM2B_26808549_Chip-Seq_REH_Human1.13284961
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13160405
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13127684
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13040788
88* TCF4_23295773_ChIP-Seq_U87_Human1.13030278
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12334254
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12050168
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10935707
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10436745
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.10252575
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.09804599
95* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09537925
96TCF4_22108803_ChIP-Seq_LS180_Human1.09080660
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08750584
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.07986847
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07210012
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05506053
101NCOR_22424771_ChIP-Seq_293T_Human1.04346183
102* ER_23166858_ChIP-Seq_MCF-7_Human1.02648827
103* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01771679
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01461907
105TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01375851
106BCAT_22108803_ChIP-Seq_LS180_Human1.01066358
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.99772030
108MYC_18940864_ChIP-ChIP_HL60_Human0.99410839
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99169928
110OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98685825
111HTT_18923047_ChIP-ChIP_STHdh_Human0.98034182
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.97880704
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97399179
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96458295
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95721218
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95190289
117* SOX2_19829295_ChIP-Seq_ESCs_Human0.95122452
118* NANOG_19829295_ChIP-Seq_ESCs_Human0.95122452
119CBP_20019798_ChIP-Seq_JUKART_Human0.94909091
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94909091
121JUN_21703547_ChIP-Seq_K562_Human0.94220909
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93812434
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93812434
124VDR_22108803_ChIP-Seq_LS180_Human0.92926697
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92583955
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92180897
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91692500
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91585626
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90342044
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90263450
131* FLI1_21867929_ChIP-Seq_TH2_Mouse0.90237782
132ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89713896
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.89324769
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.88998432
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.88816051
136AHR_22903824_ChIP-Seq_MCF-7_Human0.88285243

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.43597753
2MP0003880_abnormal_central_pattern4.20595878
3MP0009046_muscle_twitch3.66494872
4MP0003635_abnormal_synaptic_transmissio3.56591051
5MP0005423_abnormal_somatic_nervous3.11153227
6MP0002102_abnormal_ear_morphology3.02094659
7MP0001968_abnormal_touch/_nociception2.96694119
8MP0006276_abnormal_autonomic_nervous2.91666119
9MP0001501_abnormal_sleep_pattern2.90801756
10MP0002063_abnormal_learning/memory/cond2.83520261
11MP0002064_seizures2.83100972
12MP0004270_analgesia2.81131596
13MP0001984_abnormal_olfaction2.69992616
14MP0002272_abnormal_nervous_system2.69074468
15MP0009745_abnormal_behavioral_response2.67472798
16MP0002572_abnormal_emotion/affect_behav2.63796899
17MP0002734_abnormal_mechanical_nocicepti2.61647736
18MP0005551_abnormal_eye_electrophysiolog2.54054309
19MP0002736_abnormal_nociception_after2.46199218
20MP0010386_abnormal_urinary_bladder2.45307040
21MP0002735_abnormal_chemical_nociception2.44444603
22MP0002184_abnormal_innervation2.42410434
23MP0003122_maternal_imprinting2.34135752
24MP0001486_abnormal_startle_reflex2.25902460
25MP0008995_early_reproductive_senescence2.17735962
26MP0001529_abnormal_vocalization2.10397694
27MP0002067_abnormal_sensory_capabilities2.06645060
28MP0003011_delayed_dark_adaptation1.92136815
29MP0002557_abnormal_social/conspecific_i1.90132584
30MP0002909_abnormal_adrenal_gland1.87133993
31MP0004811_abnormal_neuron_physiology1.81509881
32MP0002638_abnormal_pupillary_reflex1.80378837
33MP0002733_abnormal_thermal_nociception1.79691504
34MP0001905_abnormal_dopamine_level1.79362551
35MP0005646_abnormal_pituitary_gland1.77917166
36MP0005386_behavior/neurological_phenoty1.77721194
37MP0004924_abnormal_behavior1.77721194
38MP0000778_abnormal_nervous_system1.75403143
39MP0006072_abnormal_retinal_apoptosis1.72912340
40MP0003787_abnormal_imprinting1.71600039
41MP0008569_lethality_at_weaning1.64417032
42MP0001970_abnormal_pain_threshold1.64296134
43MP0002882_abnormal_neuron_morphology1.63647399
44MP0002822_catalepsy1.63534589
45MP0004142_abnormal_muscle_tone1.61199911
46MP0000566_synostosis1.59557070
47MP0002090_abnormal_vision1.59201061
48MP0000372_irregular_coat_pigmentation1.58840418
49MP0003879_abnormal_hair_cell1.54386142
50MP0000955_abnormal_spinal_cord1.45676560
51MP0001188_hyperpigmentation1.41643686
52MP0000569_abnormal_digit_pigmentation1.40579743
53MP0005253_abnormal_eye_physiology1.35497336
54MP0002066_abnormal_motor_capabilities/c1.31892616
55MP0003329_amyloid_beta_deposits1.31430192
56MP0000049_abnormal_middle_ear1.30118962
57MP0005645_abnormal_hypothalamus_physiol1.30014717
58MP0001502_abnormal_circadian_rhythm1.29509243
59MP0001440_abnormal_grooming_behavior1.28349939
60MP0002229_neurodegeneration1.22749109
61MP0005499_abnormal_olfactory_system1.19153506
62MP0005394_taste/olfaction_phenotype1.19153506
63MP0004133_heterotaxia1.17758704
64MP0002752_abnormal_somatic_nervous1.15940818
65MP0000751_myopathy1.14309727
66MP0004742_abnormal_vestibular_system1.11134819
67MP0003119_abnormal_digestive_system1.10533073
68MP0000026_abnormal_inner_ear1.10337449
69MP0006292_abnormal_olfactory_placode1.10202917
70MP0005535_abnormal_body_temperature1.09467189
71MP0004858_abnormal_nervous_system1.08341129
72MP0002152_abnormal_brain_morphology1.07563280
73MP0000631_abnormal_neuroendocrine_gland1.07512567
74MP0003937_abnormal_limbs/digits/tail_de1.06200428
75MP0004233_abnormal_muscle_weight0.99357928
76MP0005171_absent_coat_pigmentation0.95767233
77MP0008872_abnormal_physiological_respon0.95127696
78MP0004085_abnormal_heartbeat0.94838511
79MP0003123_paternal_imprinting0.93343899
80MP0002837_dystrophic_cardiac_calcinosis0.93278221
81MP0003567_abnormal_fetal_cardiomyocyte0.92130764
82MP0004215_abnormal_myocardial_fiber0.91997587
83MP0003698_abnormal_male_reproductive0.91067437
84MP0004885_abnormal_endolymph0.90852536
85MP0003890_abnormal_embryonic-extraembry0.89564754
86MP0002751_abnormal_autonomic_nervous0.87926371
87MP0003868_abnormal_feces_composition0.87909932
88MP0002653_abnormal_ependyma_morphology0.86908922
89MP0005195_abnormal_posterior_eye0.86082335
90MP0003938_abnormal_ear_development0.85805437
91MP0002234_abnormal_pharynx_morphology0.85442601
92MP0002069_abnormal_eating/drinking_beha0.82824250
93MP0004036_abnormal_muscle_relaxation0.82253936
94MP0003632_abnormal_nervous_system0.82232550
95MP0003755_abnormal_palate_morphology0.81112581
96MP0001485_abnormal_pinna_reflex0.81082487
97MP0003121_genomic_imprinting0.81059058
98MP0008875_abnormal_xenobiotic_pharmacok0.80896040
99MP0004043_abnormal_pH_regulation0.80837879
100MP0003631_nervous_system_phenotype0.80522154
101MP0003786_premature_aging0.80448687
102MP0006035_abnormal_mitochondrial_morpho0.80398226
103MP0002233_abnormal_nose_morphology0.79986198
104MP0008789_abnormal_olfactory_epithelium0.79746725
105MP0003634_abnormal_glial_cell0.77408299
106MP0001324_abnormal_eye_pigmentation0.76362305
107MP0003195_calcinosis0.76119066
108MP0001664_abnormal_digestion0.75025065
109MP0001986_abnormal_taste_sensitivity0.73837557
110MP0001177_atelectasis0.73497837
111MP0003633_abnormal_nervous_system0.73459990
112MP0000427_abnormal_hair_cycle0.73235565
113MP0009780_abnormal_chondrocyte_physiolo0.72832697
114MP0008961_abnormal_basal_metabolism0.72806016
115MP0008877_abnormal_DNA_methylation0.71957894
116MP0003861_abnormal_nervous_system0.71101581
117MP0001963_abnormal_hearing_physiology0.69297453
118MP0001943_abnormal_respiration0.68503215
119MP0010770_preweaning_lethality0.66456701
120MP0002082_postnatal_lethality0.66456701
121MP0005187_abnormal_penis_morphology0.66059140
122MP0010769_abnormal_survival0.64676700
123MP0010768_mortality/aging0.61611819
124MP0003183_abnormal_peptide_metabolism0.60299040
125MP0003137_abnormal_impulse_conducting0.59188226
126MP0003646_muscle_fatigue0.58710558
127MP0004145_abnormal_muscle_electrophysio0.58382849

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.66635518
2Focal motor seizures (HP:0011153)5.50360998
3Progressive cerebellar ataxia (HP:0002073)5.09937906
4Absence seizures (HP:0002121)4.99197775
5Myokymia (HP:0002411)4.97610339
6Epileptic encephalopathy (HP:0200134)4.67351993
7Focal seizures (HP:0007359)4.50602286
8Dialeptic seizures (HP:0011146)4.21607827
9Visual hallucinations (HP:0002367)4.18790957
10Generalized tonic-clonic seizures (HP:0002069)3.92679949
11Febrile seizures (HP:0002373)3.91240916
12Limb dystonia (HP:0002451)3.67725340
13Atonic seizures (HP:0010819)3.64200003
14Pheochromocytoma (HP:0002666)3.64068002
15Central scotoma (HP:0000603)3.44749963
16EEG with generalized epileptiform discharges (HP:0011198)3.34835130
17Abnormality of macular pigmentation (HP:0008002)3.33713713
18Action tremor (HP:0002345)3.31114974
19Epileptiform EEG discharges (HP:0011182)3.31098956
20Truncal ataxia (HP:0002078)3.29588809
21Pancreatic cysts (HP:0001737)3.26321874
22Nephronophthisis (HP:0000090)3.24376607
23Severe visual impairment (HP:0001141)3.20296033
24True hermaphroditism (HP:0010459)3.19483282
25Pancreatic fibrosis (HP:0100732)3.18538944
26Supranuclear gaze palsy (HP:0000605)3.13268261
27Molar tooth sign on MRI (HP:0002419)3.11011704
28Abnormality of midbrain morphology (HP:0002418)3.11011704
29Type II lissencephaly (HP:0007260)3.08472403
30Neuroendocrine neoplasm (HP:0100634)3.02791416
31Hyperventilation (HP:0002883)2.97660361
32Depression (HP:0000716)2.93432787
33Gaze-evoked nystagmus (HP:0000640)2.92862493
34Drooling (HP:0002307)2.85729995
35Excessive salivation (HP:0003781)2.85729995
36Gait imbalance (HP:0002141)2.82132571
37Genetic anticipation (HP:0003743)2.79761292
38Ankle clonus (HP:0011448)2.77758133
39Broad-based gait (HP:0002136)2.75608089
40Anxiety (HP:0000739)2.72460192
41Mutism (HP:0002300)2.72357092
42Abnormality of the renal medulla (HP:0100957)2.66475258
43Dysdiadochokinesis (HP:0002075)2.64641578
44Lissencephaly (HP:0001339)2.63194753
45Urinary bladder sphincter dysfunction (HP:0002839)2.63163957
46Impaired social interactions (HP:0000735)2.63000830
47Abnormal social behavior (HP:0012433)2.63000830
48Polyphagia (HP:0002591)2.62903475
49Methylmalonic acidemia (HP:0002912)2.57493280
50Abnormal respiratory motile cilium morphology (HP:0005938)2.56913923
51Abnormal respiratory epithelium morphology (HP:0012253)2.56913923
52Abnormality of the renal cortex (HP:0011035)2.54177263
53Retinal dysplasia (HP:0007973)2.54062698
54Hypsarrhythmia (HP:0002521)2.51883698
55Decreased central vision (HP:0007663)2.48391785
56Insidious onset (HP:0003587)2.46827203
57Termporal pattern (HP:0011008)2.46827203
58Pachygyria (HP:0001302)2.46390482
59Chronic hepatic failure (HP:0100626)2.43724113
60Poor eye contact (HP:0000817)2.40647774
61Hypoventilation (HP:0002791)2.40485881
62Postural instability (HP:0002172)2.39479698
63Hypothermia (HP:0002045)2.38510290
64Cholecystitis (HP:0001082)2.38395924
65Abnormal gallbladder physiology (HP:0012438)2.38395924
66Congenital primary aphakia (HP:0007707)2.36103010
67Scotoma (HP:0000575)2.34688716
68Spastic gait (HP:0002064)2.32770266
69Abnormal ciliary motility (HP:0012262)2.32239516
70Amblyopia (HP:0000646)2.30790486
71Abnormal eating behavior (HP:0100738)2.30323079
72Absent speech (HP:0001344)2.29413459
73Progressive inability to walk (HP:0002505)2.26970466
74Impaired smooth pursuit (HP:0007772)2.26122655
75Agitation (HP:0000713)2.25364251
76Bradykinesia (HP:0002067)2.24332821
77Abnormality of ocular smooth pursuit (HP:0000617)2.22715621
78Pendular nystagmus (HP:0012043)2.21733156
79Dynein arm defect of respiratory motile cilia (HP:0012255)2.19164277
80Absent/shortened dynein arms (HP:0200106)2.19164277
81Dysmetria (HP:0001310)2.18609230
82Cerebral inclusion bodies (HP:0100314)2.16667947
83Hemiparesis (HP:0001269)2.16459616
84Medial flaring of the eyebrow (HP:0010747)2.15655430
85Dysmetric saccades (HP:0000641)2.15561385
86Nephrogenic diabetes insipidus (HP:0009806)2.14969601
87Abnormality of the corticospinal tract (HP:0002492)2.12861758
88Cerebellar dysplasia (HP:0007033)2.12278755
89Shoulder girdle muscle weakness (HP:0003547)2.11122120
90Specific learning disability (HP:0001328)2.10919746
91Athetosis (HP:0002305)2.10216320
92Stomach cancer (HP:0012126)2.10184069
93Urinary urgency (HP:0000012)2.07684110
94Vaginal atresia (HP:0000148)2.07580142
95Severe Myopia (HP:0011003)2.07563889
96Renal cortical cysts (HP:0000803)2.07526351
97Torticollis (HP:0000473)2.07113800
98Neurofibrillary tangles (HP:0002185)2.05391646
99Genital tract atresia (HP:0001827)2.03553114
100Postaxial hand polydactyly (HP:0001162)2.02322693
101Narrow forehead (HP:0000341)2.02188430
102Morphological abnormality of the pyramidal tract (HP:0002062)2.02069756
103Patellar aplasia (HP:0006443)2.02028530
104Protruding tongue (HP:0010808)2.00919166
105Tubular atrophy (HP:0000092)2.00451680
106Impaired vibration sensation in the lower limbs (HP:0002166)2.00240160
107Abnormality of the metopic suture (HP:0005556)1.99359183
108Poor coordination (HP:0002370)1.99284499
109Lower limb muscle weakness (HP:0007340)1.99110073
110Attenuation of retinal blood vessels (HP:0007843)1.96161032
111Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96045267
112Degeneration of the lateral corticospinal tracts (HP:0002314)1.96045267
113Polydipsia (HP:0001959)1.95986921
114Abnormal drinking behavior (HP:0030082)1.95986921
115Increased corneal curvature (HP:0100692)1.95685199
116Keratoconus (HP:0000563)1.95685199
117Abnormality of binocular vision (HP:0011514)1.94744194
118Diplopia (HP:0000651)1.94744194
119Abnormality of salivation (HP:0100755)1.94254502
120Cystic liver disease (HP:0006706)1.94237107
121Sclerocornea (HP:0000647)1.94142651
122Status epilepticus (HP:0002133)1.93830885
123Scanning speech (HP:0002168)1.93627688
124Focal dystonia (HP:0004373)1.93332116
125Spastic tetraplegia (HP:0002510)1.93260254
126Methylmalonic aciduria (HP:0012120)1.92865757
127Ulnar claw (HP:0001178)1.92715408
128Tubulointerstitial nephritis (HP:0001970)1.91032419
129Inability to walk (HP:0002540)1.89911156
130Optic nerve hypoplasia (HP:0000609)1.89665562
131Ventricular fibrillation (HP:0001663)1.89638440
132Hypokinesia (HP:0002375)1.89280125
133Abnormal respiratory motile cilium physiology (HP:0012261)1.88469416
134Poor suck (HP:0002033)1.88052005
135Aplasia/Hypoplasia of the patella (HP:0006498)1.86836907
136Postural tremor (HP:0002174)1.86488612
137Small hand (HP:0200055)1.85845760
138Failure to thrive in infancy (HP:0001531)1.85750693
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.85345297
140Anencephaly (HP:0002323)1.85092700
141Abnormality of the labia minora (HP:0012880)1.84623300
142Thyroid-stimulating hormone excess (HP:0002925)1.84336480
143Tubulointerstitial abnormality (HP:0001969)1.84290129
144Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84090219
145Hypoplasia of the brainstem (HP:0002365)1.84090219
146Muscular hypotonia of the trunk (HP:0008936)1.83562836
147Hemiplegia (HP:0002301)1.83558974
148Generalized myoclonic seizures (HP:0002123)1.83373327
149Prominent metopic ridge (HP:0005487)1.82691711
150Septo-optic dysplasia (HP:0100842)1.82561847
151Prolonged QT interval (HP:0001657)1.82081980
152Esotropia (HP:0000565)1.81207706
153Ketosis (HP:0001946)1.81206005
154Exercise-induced myalgia (HP:0003738)1.80662171
155Abnormal rod and cone electroretinograms (HP:0008323)1.80238774
156Gait ataxia (HP:0002066)1.79953163
157Postaxial foot polydactyly (HP:0001830)1.78653664
158Abnormality of the vitamin B12 metabolism (HP:0004341)1.73646169
159Concave nail (HP:0001598)1.70992573
160Amyotrophic lateral sclerosis (HP:0007354)1.70622177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.14188746
2NTRK34.08375652
3MAP3K43.46427339
4FRK3.38059669
5MAP4K23.18657210
6MINK13.03474327
7MAP2K72.70910973
8TRIM282.69128179
9NEK12.63837838
10MAP3K92.51735715
11PAK62.47340217
12CASK2.35827299
13BMPR1B2.16567525
14NTRK22.12384665
15PHKG11.95907911
16PHKG21.95907911
17EPHA41.89969199
18PRKD31.87379383
19SIK21.85621620
20MAP2K41.78409774
21PNCK1.76339461
22MAP3K121.73389761
23MAPK131.70062887
24ADRBK21.61071008
25ACVR1B1.59569839
26FGFR21.57799625
27DAPK21.55099836
28IRAK11.52941604
29FES1.50222606
30UHMK11.47035722
31CDK51.46830333
32PRPF4B1.34648961
33PLK21.33848765
34AKT31.32986443
35GRK51.31582695
36CDK141.30254912
37NUAK11.29645339
38STK381.28865757
39CAMK1G1.28372206
40WNK31.25346116
41LMTK21.20431575
42PAK31.20238014
43CSNK1G21.17776030
44CDK181.14587409
45CAMK2A1.14519484
46TLK11.12844242
47DAPK11.12206158
48CDK151.11884609
49RIPK11.11573733
50IRAK21.11436261
51CDK191.11036074
52OXSR11.10735119
53GRK11.10487239
54NTRK11.08579202
55NME11.07312143
56TNIK1.06035180
57INSRR1.05405808
58CAMKK11.02604740
59PRKCG1.01968700
60CAMK11.01001923
61CSNK1G31.00772478
62KSR11.00678594
63SGK4940.99402530
64SGK2230.99402530
65MARK20.98875892
66CDK11A0.97427483
67CSNK1A1L0.95813423
68MAPKAPK50.90504449
69PBK0.89710397
70SIK30.88862954
71DYRK30.88704365
72FER0.85678449
73STK38L0.85244941
74PRKAA10.83710031
75PRKCZ0.80300852
76DYRK1A0.78728626
77PRKCH0.78403946
78DYRK20.71543985
79MAPKAPK30.68734818
80ZAK0.67284120
81ROCK20.67274251
82TGFBR10.67210158
83STK390.67062659
84SGK20.66089913
85VRK10.65902362
86CAMK2D0.64545887
87YES10.63827134
88MAP3K70.63294466
89CDC42BPA0.63206371
90BCR0.62947215
91ERBB30.61812335
92RET0.61568971
93EPHA30.61408549
94PINK10.61099370
95CDK30.61076315
96LATS20.59256021
97MAP3K60.58990503
98KSR20.58457143
99PKN10.57842481
100ADRBK10.56191667
101RPS6KA30.54722159
102TAOK10.52809878
103CAMKK20.51119709
104SGK10.49331719
105MKNK20.49093022
106STK110.49060595
107EPHB20.48324622
108PRKG10.47638647
109CSNK1G10.47241240
110CAMK40.46487214
111SGK30.46171030
112PRKCE0.46157807
113RPS6KA20.46128942
114ALK0.46042950
115PRKCB0.44983168
116CAMK1D0.44810183
117CAMK2B0.44352856
118MAPK100.44347853
119MAPK150.43753506
120MAP3K130.43267710
121SRPK10.43028588
122CCNB10.42966861
123PRKD20.42754930
124PRKACA0.42349112
125MUSK0.41918281
126BRSK10.41592208
127MAPK90.39245926
128MAP3K50.39043271
129TIE10.38740633
130PRKCA0.38646938
131ROCK10.38417822
132CSNK1A10.37845888
133CSNK1D0.37642260
134DYRK1B0.36972223
135WNK40.34498173
136CSNK1E0.32943693
137ERBB20.32328166
138PLK40.30914231
139MAPK80.30028073
140PRKACB0.29035761
141RPS6KA40.28083572

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.49877618
2Nicotine addiction_Homo sapiens_hsa050333.88633978
3GABAergic synapse_Homo sapiens_hsa047273.54286338
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.98736583
5Morphine addiction_Homo sapiens_hsa050322.98097300
6Circadian entrainment_Homo sapiens_hsa047132.68614497
7Olfactory transduction_Homo sapiens_hsa047402.58928710
8Insulin secretion_Homo sapiens_hsa049112.50937280
9Glutamatergic synapse_Homo sapiens_hsa047242.45457244
10Dopaminergic synapse_Homo sapiens_hsa047282.37000469
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36454640
12Serotonergic synapse_Homo sapiens_hsa047262.35843560
13Salivary secretion_Homo sapiens_hsa049702.26140150
14Taste transduction_Homo sapiens_hsa047422.10762258
15Cholinergic synapse_Homo sapiens_hsa047252.06623744
16Collecting duct acid secretion_Homo sapiens_hsa049662.02258441
17Amphetamine addiction_Homo sapiens_hsa050311.90082195
18Basal transcription factors_Homo sapiens_hsa030221.74542676
19Linoleic acid metabolism_Homo sapiens_hsa005911.72051222
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70020129
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69126538
22Renin secretion_Homo sapiens_hsa049241.66314120
23Long-term potentiation_Homo sapiens_hsa047201.65922113
24Cocaine addiction_Homo sapiens_hsa050301.65618000
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62341756
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62065732
27Cardiac muscle contraction_Homo sapiens_hsa042601.48696874
28Gastric acid secretion_Homo sapiens_hsa049711.46933815
29Protein export_Homo sapiens_hsa030601.46798720
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45898148
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.44727488
32Fanconi anemia pathway_Homo sapiens_hsa034601.42239552
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39166985
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36763952
35Oxytocin signaling pathway_Homo sapiens_hsa049211.36410853
36Phototransduction_Homo sapiens_hsa047441.34567536
37Calcium signaling pathway_Homo sapiens_hsa040201.34057804
38Regulation of autophagy_Homo sapiens_hsa041401.33900152
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32927483
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32697131
41Vibrio cholerae infection_Homo sapiens_hsa051101.30895616
42Gap junction_Homo sapiens_hsa045401.30358350
43Long-term depression_Homo sapiens_hsa047301.27713172
44Type II diabetes mellitus_Homo sapiens_hsa049301.26149158
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25429270
46Ether lipid metabolism_Homo sapiens_hsa005651.23957219
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23729618
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22419841
49Propanoate metabolism_Homo sapiens_hsa006401.21659951
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21343815
51Nitrogen metabolism_Homo sapiens_hsa009101.14613813
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12150043
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10961091
54Tryptophan metabolism_Homo sapiens_hsa003801.09302502
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07606496
56ABC transporters_Homo sapiens_hsa020101.03363820
57Caffeine metabolism_Homo sapiens_hsa002321.02748738
58GnRH signaling pathway_Homo sapiens_hsa049121.00182343
59Axon guidance_Homo sapiens_hsa043600.99952925
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97229113
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92052228
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.91455383
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87957093
64beta-Alanine metabolism_Homo sapiens_hsa004100.86212529
65Dilated cardiomyopathy_Homo sapiens_hsa054140.85329542
66Melanogenesis_Homo sapiens_hsa049160.82200156
67ErbB signaling pathway_Homo sapiens_hsa040120.80182434
68Butanoate metabolism_Homo sapiens_hsa006500.77639636
69cAMP signaling pathway_Homo sapiens_hsa040240.76258323
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74045883
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74029486
72Thyroid hormone synthesis_Homo sapiens_hsa049180.73030787
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72476706
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71797468
75Oocyte meiosis_Homo sapiens_hsa041140.71421588
76Estrogen signaling pathway_Homo sapiens_hsa049150.71086969
77Selenocompound metabolism_Homo sapiens_hsa004500.70975185
78Oxidative phosphorylation_Homo sapiens_hsa001900.70763135
79Alcoholism_Homo sapiens_hsa050340.69277455
80Pancreatic secretion_Homo sapiens_hsa049720.67124919
81Parkinsons disease_Homo sapiens_hsa050120.66179561
82Circadian rhythm_Homo sapiens_hsa047100.65668092
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.63836079
84Glioma_Homo sapiens_hsa052140.63517509
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62701658
86Glucagon signaling pathway_Homo sapiens_hsa049220.61393292
87mTOR signaling pathway_Homo sapiens_hsa041500.58894515
88MAPK signaling pathway_Homo sapiens_hsa040100.57200180
89Retinol metabolism_Homo sapiens_hsa008300.56907305
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.54887492
91Choline metabolism in cancer_Homo sapiens_hsa052310.54194888
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53591316
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51921112
94RNA polymerase_Homo sapiens_hsa030200.51878946
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51251885
96Hedgehog signaling pathway_Homo sapiens_hsa043400.49573324
97Prolactin signaling pathway_Homo sapiens_hsa049170.49243855
98Glycerolipid metabolism_Homo sapiens_hsa005610.48707628
99Ovarian steroidogenesis_Homo sapiens_hsa049130.48588157
100RNA degradation_Homo sapiens_hsa030180.48099454
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48018011
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47533777
103Steroid biosynthesis_Homo sapiens_hsa001000.46440098
104Chemical carcinogenesis_Homo sapiens_hsa052040.46201597
105Type I diabetes mellitus_Homo sapiens_hsa049400.45404897
106Histidine metabolism_Homo sapiens_hsa003400.45374364
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44578744
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44336878
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44248163
110Alzheimers disease_Homo sapiens_hsa050100.43570311
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43333094
112Ras signaling pathway_Homo sapiens_hsa040140.42934320
113Sulfur metabolism_Homo sapiens_hsa009200.42454371
114Peroxisome_Homo sapiens_hsa041460.42355117
115Inositol phosphate metabolism_Homo sapiens_hsa005620.41228034
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40166856
117Bile secretion_Homo sapiens_hsa049760.38671321
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38223360
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.38176927
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36176656
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35186110
122Non-homologous end-joining_Homo sapiens_hsa034500.34741631
123Insulin signaling pathway_Homo sapiens_hsa049100.34475897
124Endocytosis_Homo sapiens_hsa041440.34202476
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33745967
126Homologous recombination_Homo sapiens_hsa034400.32734605
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32081243
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31772761
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31574718
130Pyruvate metabolism_Homo sapiens_hsa006200.30954281
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30880041
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.30876460
133Wnt signaling pathway_Homo sapiens_hsa043100.30862879
134Fat digestion and absorption_Homo sapiens_hsa049750.30702985
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.30400247
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29884051
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.29781547
138Hippo signaling pathway_Homo sapiens_hsa043900.29132237
139African trypanosomiasis_Homo sapiens_hsa051430.28934424
140Rap1 signaling pathway_Homo sapiens_hsa040150.28243904
141Rheumatoid arthritis_Homo sapiens_hsa053230.28156709
142Dorso-ventral axis formation_Homo sapiens_hsa043200.28003072
143Colorectal cancer_Homo sapiens_hsa052100.27086051
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26180438
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25979612
146Huntingtons disease_Homo sapiens_hsa050160.24790209
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24579849

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