ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	6.06473627
2	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	6.06473627
3	positive regulation of gamma-delta T cell activation (GO:0046645)	6.00926245
4	antigen processing and presentation of endogenous antigen (GO:0019883)	5.17500501
5	leukocyte aggregation (GO:0070486)	5.12411322
6	ribosomal small subunit assembly (GO:0000028)	5.09289006
7	regulation of gamma-delta T cell differentiation (GO:0045586)	4.84651696
8	valine metabolic process (GO:0006573)	4.72575861
9	regulation of gamma-delta T cell activation (GO:0046643)	4.55021511
10	negative regulation of erythrocyte differentiation (GO:0045647)	4.49421810
11	neutrophil activation involved in immune response (GO:0002283)	4.47729709
12	detection of bacterium (GO:0016045)	4.34990006
13	tolerance induction (GO:0002507)	4.29377831
14	T cell selection (GO:0045058)	4.22956950
15	detection of other organism (GO:0098543)	4.18203044
16	positive T cell selection (GO:0043368)	4.10167737
17	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.99315793
18	negative regulation of lymphocyte mediated immunity (GO:0002707)	3.99048315
19	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.98972569
20	immunoglobulin mediated immune response (GO:0016064)	3.79156377
21	positive regulation by symbiont of host defense response (GO:0052509)	3.77987330
22	modulation by symbiont of host defense response (GO:0052031)	3.77987330
23	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	3.77987330
24	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	3.77987330
25	positive regulation by organism of defense response of other organism involved in symbiotic interact	3.77987330
26	modulation by symbiont of host immune response (GO:0052553)	3.77987330
27	viral transcription (GO:0019083)	3.76187194
28	regulation of T cell tolerance induction (GO:0002664)	3.75539434
29	antigen processing and presentation via MHC class Ib (GO:0002475)	3.75095464
30	negative regulation of leukocyte mediated immunity (GO:0002704)	3.71333410
31	response to interleukin-15 (GO:0070672)	3.67266533
32	T cell migration (GO:0072678)	3.67217929
33	positive regulation of B cell differentiation (GO:0045579)	3.62411715
34	translational termination (GO:0006415)	3.61804476
35	regulation of tolerance induction (GO:0002643)	3.61528288
36	cellular response to interleukin-15 (GO:0071350)	3.51984453
37	regulation of alpha-beta T cell proliferation (GO:0046640)	3.51367602
38	negative regulation of T cell mediated immunity (GO:0002710)	3.49532654
39	Peyers patch development (GO:0048541)	3.48395178
40	mucosal-associated lymphoid tissue development (GO:0048537)	3.48395178
41	DNA deamination (GO:0045006)	3.42921747
42	negative regulation of interleukin-12 production (GO:0032695)	3.36488749
43	neutrophil activation (GO:0042119)	3.33851372
44	positive regulation of tolerance induction (GO:0002645)	3.33118740
45	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.32290279
46	negative T cell selection (GO:0043383)	3.30994044
47	response to peptidoglycan (GO:0032494)	3.27211920
48	negative thymic T cell selection (GO:0045060)	3.26286929
49	negative regulation of phagocytosis (GO:0050765)	3.25838532
50	regulation of mast cell degranulation (GO:0043304)	3.25150819
51	translational elongation (GO:0006414)	3.23688640
52	B cell receptor signaling pathway (GO:0050853)	3.22783333
53	regulation of regulatory T cell differentiation (GO:0045589)	3.22395054
54	regulation of B cell differentiation (GO:0045577)	3.20329921
55	macrophage activation involved in immune response (GO:0002281)	3.18725725
56	negative regulation of innate immune response (GO:0045824)	3.17901900
57	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.16020914
58	regulation of dendritic cell antigen processing and presentation (GO:0002604)	3.13531452
59	response to muramyl dipeptide (GO:0032495)	3.13472422
60	activated T cell proliferation (GO:0050798)	3.12848159
61	respiratory burst (GO:0045730)	3.10097494
62	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	3.08056870
63	cotranslational protein targeting to membrane (GO:0006613)	3.06567171
64	definitive hemopoiesis (GO:0060216)	3.06270388
65	protein targeting to ER (GO:0045047)	3.05491846
66	signal complex assembly (GO:0007172)	3.03841825
67	positive thymic T cell selection (GO:0045059)	3.03820029
68	granulocyte activation (GO:0036230)	3.03296141
69	myeloid cell activation involved in immune response (GO:0002275)	3.02672222
70	leukocyte degranulation (GO:0043299)	3.01816978
71	detection of external biotic stimulus (GO:0098581)	3.00310350
72	regulation of interleukin-2 biosynthetic process (GO:0045076)	2.97575412
73	maturation of SSU-rRNA (GO:0030490)	2.96580043
74	ribosomal small subunit biogenesis (GO:0042274)	2.96136643
75	negative regulation of glycoprotein biosynthetic process (GO:0010561)	2.95215615
76	protein localization to endoplasmic reticulum (GO:0070972)	2.94733524
77	interferon-gamma secretion (GO:0072643)	2.94078108
78	regulation of myeloid leukocyte mediated immunity (GO:0002886)	2.93789474
79	positive regulation of immune response to tumor cell (GO:0002839)	2.91088771
80	regulation of immune response to tumor cell (GO:0002837)	2.91088771
81	regulation of response to tumor cell (GO:0002834)	2.91088771
82	positive regulation of response to tumor cell (GO:0002836)	2.91088771
83	regulation of T cell mediated cytotoxicity (GO:0001914)	2.89119527
84	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.88708532
85	regulation of interferon-beta biosynthetic process (GO:0045357)	2.88690965
86	regulation of mast cell activation involved in immune response (GO:0033006)	2.88521545
87	regulation of leukocyte degranulation (GO:0043300)	2.88244395
88	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.87636608
89	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.87553939
90	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.87553939
91	positive regulation of antigen processing and presentation (GO:0002579)	2.86899419
92	negative regulation of cytokine production involved in immune response (GO:0002719)	2.85776934
93	oxaloacetate metabolic process (GO:0006107)	2.84995384
94	negative regulation of interleukin-6 production (GO:0032715)	2.84385645
95	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.83009936
96	regulation of antigen processing and presentation (GO:0002577)	2.82898987
97	regulation of B cell receptor signaling pathway (GO:0050855)	2.82154063
98	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.81875248
99	mature B cell differentiation involved in immune response (GO:0002313)	2.80482422
100	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.80037874
101	T cell homeostasis (GO:0043029)	2.79611079
102	response to interferon-beta (GO:0035456)	2.79544212
103	viral life cycle (GO:0019058)	2.79469257
104	regulation of response to interferon-gamma (GO:0060330)	2.79377283
105	negative regulation of cell killing (GO:0031342)	2.78959433
106	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.78959433
107	positive regulation of natural killer cell differentiation (GO:0032825)	2.78686564
108	positive regulation of interleukin-17 production (GO:0032740)	2.78350821
109	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.76671338
110	B cell mediated immunity (GO:0019724)	2.75936203
111	tricarboxylic acid metabolic process (GO:0072350)	2.75798717
112	NIK/NF-kappaB signaling (GO:0038061)	2.75078084
113	mannose metabolic process (GO:0006013)	2.74814823
114	interferon-gamma-mediated signaling pathway (GO:0060333)	2.74653362
115	regulation of interferon-gamma-mediated signaling pathway (GO:0060334)	2.74418116
116	cellular extravasation (GO:0045123)	2.73990489
117	thymic T cell selection (GO:0045061)	2.73832674
118	germinal center formation (GO:0002467)	2.73716105
119	lymphocyte migration (GO:0072676)	2.73602346
120	mast cell activation (GO:0045576)	2.72971504
121	regulation of defense response to virus by virus (GO:0050690)	2.72709302
122	regulation of natural killer cell differentiation (GO:0032823)	2.72149860
123	regulation of natural killer cell mediated immunity (GO:0002715)	2.70746061
124	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.70746061
125	lymph node development (GO:0048535)	2.70037779
126	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.68532696
127	response to type I interferon (GO:0034340)	2.68104866
128	cellular response to type I interferon (GO:0071357)	2.67009334
129	type I interferon signaling pathway (GO:0060337)	2.67009334
130	regulation of T cell receptor signaling pathway (GO:0050856)	2.65857695
131	urate metabolic process (GO:0046415)	2.65378901
132	megakaryocyte development (GO:0035855)	2.65043647
133	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.64943724
134	L-phenylalanine metabolic process (GO:0006558)	2.64784562
135	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.64784562
136	indole-containing compound catabolic process (GO:0042436)	2.63763541
137	indolalkylamine catabolic process (GO:0046218)	2.63763541
138	tryptophan catabolic process (GO:0006569)	2.63763541
139	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.62489537
140	2-oxoglutarate metabolic process (GO:0006103)	2.60275919
141	cellular protein complex disassembly (GO:0043624)	2.60217674
142	aromatic amino acid family catabolic process (GO:0009074)	2.59846607
143	interferon-gamma production (GO:0032609)	2.58665612
144	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.57394994
145	translational initiation (GO:0006413)	2.56283540
146	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.53052821
147	L-phenylalanine catabolic process (GO:0006559)	2.53052821
148	branched-chain amino acid metabolic process (GO:0009081)	2.52145922
149	T cell receptor signaling pathway (GO:0050852)	2.51921251
150	drug transport (GO:0015893)	2.50027367
151	glyoxylate metabolic process (GO:0046487)	2.49083060
152	tryptophan metabolic process (GO:0006568)	2.49022741
153	antigen receptor-mediated signaling pathway (GO:0050851)	2.48935418
154	positive regulation of humoral immune response (GO:0002922)	2.47931702
155	regulation of isotype switching to IgG isotypes (GO:0048302)	2.47126756
156	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.45851285
157	natural killer cell differentiation (GO:0001779)	2.44876688
158	positive regulation of granulocyte differentiation (GO:0030854)	2.42866693
159	JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)	2.39818845
160	drug transmembrane transport (GO:0006855)	2.39312484

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.89208944
2	E2F7_22180533_ChIP-Seq_HELA_Human	3.61900425
3	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.14828895
4	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.05683941
5	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	3.00438927
6	SCL_19346495_ChIP-Seq_HPC-7_Human	2.78626870
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.77722013
8	GATA1_22025678_ChIP-Seq_K562_Human	2.64899451
9	MYC_22102868_ChIP-Seq_BL_Human	2.62644649
10	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.62548594
11	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.58816183
12	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	2.53467966
13	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.43188858
14	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.42129919
15	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.25683967
16	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	2.24639870
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.23591655
18	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	2.19556793
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.18796760
20	STAT4_19710469_ChIP-ChIP_TH1__Mouse	2.15201760
21	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.13402412
22	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.11607268
23	LXR_22292898_ChIP-Seq_THP-1_Human	2.11547300
24	VDR_21846776_ChIP-Seq_THP-1_Human	2.09766782
25	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.09522091
26	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.05677881
27	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.00388380
28	* MYB_26560356_Chip-Seq_TH2_Human	1.97160113
29	* KDM2B_26808549_Chip-Seq_DND41_Human	1.96283934
30	MAF_26560356_Chip-Seq_TH1_Human	1.94508410
31	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.93057953
32	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.88067388
33	* MYB_26560356_Chip-Seq_TH1_Human	1.87056157
34	SPI1_23547873_ChIP-Seq_NB4_Human	1.80845465
35	RUNX_20019798_ChIP-Seq_JUKART_Human	1.78920088
36	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.75633207
37	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.73700932
38	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.69138867
39	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.68487171
40	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.68486063
41	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.68138699
42	UTX_26944678_Chip-Seq_JUKART_Human	1.66879927
43	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.63232539
44	BCL6_27268052_Chip-Seq_Bcells_Human	1.61820009
45	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.61577228
46	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.59102202
47	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.59035892
48	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.55637790
49	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.54775480
50	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.54139440
51	P68_20966046_ChIP-Seq_HELA_Human	1.54119316
52	BCOR_27268052_Chip-Seq_Bcells_Human	1.52433915
53	VDR_23849224_ChIP-Seq_CD4+_Human	1.49422844
54	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.49035341
55	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.48549024
56	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47753847
57	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.47195965
58	RACK7_27058665_Chip-Seq_MCF-7_Human	1.46950614
59	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.46273970
60	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.45617049
61	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.45410995
62	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.44231518
63	* SA1_27219007_Chip-Seq_ERYTHROID_Human	1.43991192
64	* MAF_26560356_Chip-Seq_TH2_Human	1.43870367
65	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.43290732
66	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.42213352
67	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.39950332
68	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.38646279
69	* CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.37069137
70	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.36668811
71	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.36432028
72	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.36193732
73	VDR_24763502_ChIP-Seq_THP-1_Human	1.35151667
74	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.34102838
75	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.34073580
76	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.33489204
77	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.33271890
78	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.32902633
79	XRN2_22483619_ChIP-Seq_HELA_Human	1.32542175
80	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.32511708
81	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.31869742
82	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.31641572
83	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.31001678
84	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.30736502
85	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.30713353
86	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.30586074
87	* TCF7_22412390_ChIP-Seq_EML_Mouse	1.29030434
88	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.28982527
89	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.28673515
90	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.28442686
91	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.27508193
92	NCOR1_26117541_ChIP-Seq_K562_Human	1.26274239
93	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.25901882
94	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.22437306
95	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.21757826
96	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.21366050
97	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.21364094
98	CIITA_25753668_ChIP-Seq_RAJI_Human	1.18180232
99	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.17144180
100	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.15638633
101	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.14956541
102	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.14488329
103	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.14446002
104	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.13240752
105	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12726006
106	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.12507476
107	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.12106811
108	GATA3_27048872_Chip-Seq_THYMUS_Human	1.10528107
109	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.10318013
110	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.10155474
111	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.08757522
112	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.08392128
113	SMC4_20622854_ChIP-Seq_HELA_Human	1.08311423
114	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.07709754
115	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.06348013
116	E2F1_20622854_ChIP-Seq_HELA_Human	1.05593882
117	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.05514636
118	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.05176003
119	GABP_19822575_ChIP-Seq_HepG2_Human	1.04862502
120	PHF8_20622854_ChIP-Seq_HELA_Human	1.04802230
121	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.04525413
122	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.02574908
123	GATA1_19941826_ChIP-Seq_K562_Human	1.02339820
124	P300_27268052_Chip-Seq_Bcells_Human	1.01825178
125	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.01660688
126	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99550327
127	* ELK3_25401928_ChIP-Seq_HUVEC_Human	0.99342939
128	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.99026282
129	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.98539959
130	* STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.97503074
131	* SA1_27219007_Chip-Seq_Bcells_Human	0.97432923
132	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.97069656
133	* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.97023574
134	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.96753473
135	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.96237975
136	SPI1_23127762_ChIP-Seq_K562_Human	0.95081621
137	* KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.94444230
138	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	0.94092301
139	DCP1A_22483619_ChIP-Seq_HELA_Human	0.93392887
140	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.92671953

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	3.11353423
2	MP0003763_abnormal_thymus_physiology	2.97235510
3	MP0005671_abnormal_response_to	2.97101972
4	MP0003303_peritoneal_inflammation	2.96762769
5	MP0001835_abnormal_antigen_presentation	2.93517759
6	MP0002396_abnormal_hematopoietic_system	2.93479417
7	MP0002139_abnormal_hepatobiliary_system	2.90740577
8	MP0000685_abnormal_immune_system	2.75743367
9	MP0005365_abnormal_bile_salt	2.64957312
10	MP0009785_altered_susceptibility_to	2.55295484
11	MP0002166_altered_tumor_susceptibility	2.32551584
12	MP0001800_abnormal_humoral_immune	2.28077253
13	MP0005085_abnormal_gallbladder_physiolo	2.23559694
14	MP0001873_stomach_inflammation	2.17756504
15	MP0008875_abnormal_xenobiotic_pharmacok	2.15398099
16	MP0002398_abnormal_bone_marrow	2.09847139
17	MP0005025_abnormal_response_to	2.06727128
18	MP0003724_increased_susceptibility_to	2.01509890
19	MP0002420_abnormal_adaptive_immunity	1.98200941
20	* MP0002723_abnormal_immune_serum	1.97764498
21	MP0005464_abnormal_platelet_physiology	1.96240083
22	* MP0001819_abnormal_immune_cell	1.94747066
23	MP0000689_abnormal_spleen_morphology	1.94027431
24	MP0005387_immune_system_phenotype	1.93066981
25	MP0001790_abnormal_immune_system	1.93066981
26	MP0001533_abnormal_skeleton_physiology	1.91928983
27	* MP0002452_abnormal_antigen_presenting	1.88641021
28	MP0005000_abnormal_immune_tolerance	1.88167582
29	MP0002722_abnormal_immune_system	1.85735545
30	MP0000716_abnormal_immune_system	1.81751974
31	MP0002138_abnormal_hepatobiliary_system	1.79538942
32	MP0005058_abnormal_lysosome_morphology	1.79538023
33	MP0004808_abnormal_hematopoietic_stem	1.77590800
34	MP0008260_abnormal_autophagy	1.74188399
35	MP0002006_tumorigenesis	1.72695805
36	MP0001545_abnormal_hematopoietic_system	1.71613262
37	MP0005397_hematopoietic_system_phenotyp	1.71613262
38	MP0001853_heart_inflammation	1.68745495
39	* MP0010155_abnormal_intestine_physiology	1.68005525
40	MP0003436_decreased_susceptibility_to	1.66705279
41	MP0002429_abnormal_blood_cell	1.66187081
42	MP0003191_abnormal_cellular_cholesterol	1.65938781
43	MP0003866_abnormal_defecation	1.63270485
44	MP0003806_abnormal_nucleotide_metabolis	1.60965556
45	MP0000703_abnormal_thymus_morphology	1.60114554
46	MP0009840_abnormal_foam_cell	1.55607503
47	MP0005075_abnormal_melanosome_morpholog	1.53522110
48	MP0002405_respiratory_system_inflammati	1.53448661
49	* MP0009333_abnormal_splenocyte_physiolog	1.51154041
50	MP0003172_abnormal_lysosome_physiology	1.49699679
51	MP0002419_abnormal_innate_immunity	1.48496634
52	* MP0001845_abnormal_inflammatory_respons	1.45661857
53	MP0000465_gastrointestinal_hemorrhage	1.43688253
54	MP0008469_abnormal_protein_level	1.41443423
55	MP0000490_abnormal_crypts_of	1.40469016
56	MP0004381_abnormal_hair_follicle	1.39358072
57	MP0004947_skin_inflammation	1.37267179
58	MP0003252_abnormal_bile_duct	1.37039747
59	MP0003693_abnormal_embryo_hatching	1.36800210
60	MP0005451_abnormal_body_composition	1.35728271
61	MP0006082_CNS_inflammation	1.34712124
62	MP0002254_reproductive_system_inflammat	1.33794648
63	MP0001851_eye_inflammation	1.33026410
64	MP0009643_abnormal_urine_homeostasis	1.31811837
65	MP0000609_abnormal_liver_physiology	1.31266260
66	MP0010329_abnormal_lipoprotein_level	1.31084799
67	MP0002148_abnormal_hypersensitivity_rea	1.29807333
68	MP0001666_abnormal_nutrient_absorption	1.29342039
69	MP0002277_abnormal_respiratory_mucosa	1.24704654
70	MP0003186_abnormal_redox_activity	1.23299329
71	MP0005332_abnormal_amino_acid	1.22402833
72	MP0009764_decreased_sensitivity_to	1.20555807
73	MP0001764_abnormal_homeostasis	1.18207495
74	MP0003300_gastrointestinal_ulcer	1.18114613
75	MP0004147_increased_porphyrin_level	1.18113643
76	MP0002019_abnormal_tumor_incidence	1.16577620
77	MP0005084_abnormal_gallbladder_morpholo	1.16042446
78	MP0001663_abnormal_digestive_system	1.14590259
79	MP0002933_joint_inflammation	1.12912002
80	MP0002998_abnormal_bone_remodeling	1.09695017
81	MP0003183_abnormal_peptide_metabolism	1.07981825
82	MP0004019_abnormal_vitamin_homeostasis	1.07879632
83	MP0009765_abnormal_xenobiotic_induced	1.06230168
84	MP0000598_abnormal_liver_morphology	1.05215468
85	MP0005636_abnormal_mineral_homeostasis	1.04752687
86	MP0005319_abnormal_enzyme/_coenzyme	1.04387851
87	MP0003828_pulmonary_edema	1.04028606
88	MP0009278_abnormal_bone_marrow	1.02754874
89	MP0009763_increased_sensitivity_to	1.02350537
90	MP0008058_abnormal_DNA_repair	1.00483455
91	MP0005166_decreased_susceptibility_to	0.99461462
92	MP0005584_abnormal_enzyme/coenzyme_acti	0.98574731
93	MP0002136_abnormal_kidney_physiology	0.98148389
94	MP0005083_abnormal_biliary_tract	0.98059336
95	MP0003075_altered_response_to	0.97684334
96	MP0002132_abnormal_respiratory_system	0.94272766
97	MP0003656_abnormal_erythrocyte_physiolo	0.94078826
98	MP0000858_altered_metastatic_potential	0.93900927
99	MP0010094_abnormal_chromosome_stability	0.93319693
100	MP0003943_abnormal_hepatobiliary_system	0.92731292
101	MP0005310_abnormal_salivary_gland	0.92479626
102	MP0005174_abnormal_tail_pigmentation	0.91504759
103	MP0008057_abnormal_DNA_replication	0.90300802
104	MP0006036_abnormal_mitochondrial_physio	0.89873657
105	MP0001986_abnormal_taste_sensitivity	0.89252380
106	MP0003868_abnormal_feces_composition	0.88019965
107	MP0003077_abnormal_cell_cycle	0.86994923
108	MP0005390_skeleton_phenotype	0.85952259
109	MP0009379_abnormal_foot_pigmentation	0.83672985
110	MP0003448_altered_tumor_morphology	0.82818274
111	MP0004883_abnormal_blood_vessel	0.79484631
112	MP0004957_abnormal_blastocyst_morpholog	0.79048950
113	MP0004510_myositis	0.75773370
114	MP0002118_abnormal_lipid_homeostasis	0.75155831
115	MP0008004_abnormal_stomach_pH	0.74374124
116	MP0000477_abnormal_intestine_morphology	0.74158454
117	MP0004185_abnormal_adipocyte_glucose	0.73854958
118	MP0002928_abnormal_bile_duct	0.72380719
119	MP0005381_digestive/alimentary_phenotyp	0.72212366
120	MP0008007_abnormal_cellular_replicative	0.72094508
121	MP0002095_abnormal_skin_pigmentation	0.72033231
122	MP0004264_abnormal_extraembryonic_tissu	0.71898289
123	MP0000249_abnormal_blood_vessel	0.66439927
124	MP0000678_abnormal_parathyroid_gland	0.63861549
125	MP0003795_abnormal_bone_structure	0.62115566
126	MP0005164_abnormal_response_to	0.60567515
127	MP0002009_preneoplasia	0.60409318
128	MP0001765_abnormal_ion_homeostasis	0.57808408
129	MP0003453_abnormal_keratinocyte_physiol	0.56323872
130	MP0008874_decreased_physiological_sensi	0.55590952
131	MP0000343_altered_response_to	0.54435895

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Recurrent bacterial skin infections (HP:0005406)	4.79266688
2	Abnormality of macrophages (HP:0004311)	4.62462840
3	IgM deficiency (HP:0002850)	4.59072355
4	Orchitis (HP:0100796)	4.54583320
5	Stomatitis (HP:0010280)	4.26783172
6	Thrombocytosis (HP:0001894)	4.26144755
7	Retrobulbar optic neuritis (HP:0100654)	4.23104759
8	Optic neuritis (HP:0100653)	4.23104759
9	Recurrent bronchitis (HP:0002837)	3.87532580
10	Obstructive lung disease (HP:0006536)	3.84341456
11	Chronic obstructive pulmonary disease (HP:0006510)	3.84341456
12	Elevated erythrocyte sedimentation rate (HP:0003565)	3.82973427
13	Chronic otitis media (HP:0000389)	3.79868067
14	Recurrent gram-negative bacterial infections (HP:0005420)	3.64596286
15	T lymphocytopenia (HP:0005403)	3.55525136
16	Mediastinal lymphadenopathy (HP:0100721)	3.55396326
17	Gastrointestinal infarctions (HP:0005244)	3.54976494
18	Increased IgE level (HP:0003212)	3.51936607
19	Abnormality of T cells (HP:0002843)	3.41882465
20	Abnormality of T cell number (HP:0011839)	3.40717512
21	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.35195962
22	Petechiae (HP:0000967)	3.24287403
23	Vasculitis (HP:0002633)	3.15212618
24	Myositis (HP:0100614)	3.13355774
25	Abnormality of T cell physiology (HP:0011840)	3.06207779
26	Keratoconjunctivitis sicca (HP:0001097)	3.05419112
27	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.03231711
28	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.03231711
29	Abnormality of the nasal mucosa (HP:0000433)	3.01864782
30	Epistaxis (HP:0000421)	2.87633624
31	Generalized aminoaciduria (HP:0002909)	2.85611065
32	Severe combined immunodeficiency (HP:0004430)	2.85480570
33	Nasal polyposis (HP:0100582)	2.83979740
34	Granulocytopenia (HP:0001913)	2.83610464
35	Cellulitis (HP:0100658)	2.83350768
36	Keratoconjunctivitis (HP:0001096)	2.82178239
37	IgG deficiency (HP:0004315)	2.82134284
38	Reticulocytopenia (HP:0001896)	2.81555414
39	Urticaria (HP:0001025)	2.81505874
40	Prolonged bleeding time (HP:0003010)	2.76478248
41	Chest pain (HP:0100749)	2.76217499
42	Combined immunodeficiency (HP:0005387)	2.75689608
43	Gingivitis (HP:0000230)	2.75161759
44	Pulmonary infiltrates (HP:0002113)	2.75061109
45	Pustule (HP:0200039)	2.72645620
46	Hypochromic anemia (HP:0001931)	2.68449787
47	Aplastic anemia (HP:0001915)	2.68152577
48	Spontaneous hematomas (HP:0007420)	2.64725257
49	Increased IgM level (HP:0003496)	2.62131831
50	Abnormality of cells of the erythroid lineage (HP:0012130)	2.61711407
51	B lymphocytopenia (HP:0010976)	2.57486127
52	Abnormality of B cell number (HP:0010975)	2.57486127
53	Lymphopenia (HP:0001888)	2.57479832
54	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.56563086
55	Hemoptysis (HP:0002105)	2.55502761
56	Panhypogammaglobulinemia (HP:0003139)	2.55498574
57	Poikiloderma (HP:0001029)	2.54441304
58	Abnormal number of erythroid precursors (HP:0012131)	2.54361120
59	Hypoplasia of the thymus (HP:0000778)	2.54241682
60	Recurrent fungal infections (HP:0002841)	2.51028589
61	Thyroiditis (HP:0100646)	2.50673424
62	Anorexia (HP:0002039)	2.50082931
63	Leukocytosis (HP:0001974)	2.50003838
64	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.49957883
65	Abnormal platelet function (HP:0011869)	2.48732707
66	Impaired platelet aggregation (HP:0003540)	2.48732707
67	Chronic diarrhea (HP:0002028)	2.48381928
68	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.48032382
69	Autoimmune hemolytic anemia (HP:0001890)	2.46513652
70	Increased serum ferritin (HP:0003281)	2.46367118
71	IgA deficiency (HP:0002720)	2.45334349
72	Recurrent viral infections (HP:0004429)	2.44607681
73	Seborrheic dermatitis (HP:0001051)	2.43738896
74	Pulmonary embolism (HP:0002204)	2.43675642
75	Gingival bleeding (HP:0000225)	2.42130492
76	Intrahepatic cholestasis (HP:0001406)	2.41976628
77	Verrucae (HP:0200043)	2.40079054
78	Papilloma (HP:0012740)	2.40079054
79	Abnormality of the fingertips (HP:0001211)	2.36364960
80	Entropion (HP:0000621)	2.35056139
81	Chronic mucocutaneous candidiasis (HP:0002728)	2.31109461
82	Recurrent cutaneous fungal infections (HP:0011370)	2.31109461
83	Dysostosis multiplex (HP:0000943)	2.30014860
84	Microcytic anemia (HP:0001935)	2.29373001
85	Interstitial pulmonary disease (HP:0006530)	2.26834701
86	Joint swelling (HP:0001386)	2.26208064
87	Gastrointestinal inflammation (HP:0004386)	2.25633145
88	Bronchitis (HP:0012387)	2.25000289
89	Hepatosplenomegaly (HP:0001433)	2.24720369
90	Episodic fever (HP:0001954)	2.22504851
91	Hypergammaglobulinemia (HP:0010702)	2.22135255
92	Reduced antithrombin III activity (HP:0001976)	2.21651083
93	Papilledema (HP:0001085)	2.20885257
94	Recurrent sinusitis (HP:0011108)	2.20633216
95	Hypobetalipoproteinemia (HP:0003563)	2.19228564
96	Inflammation of the large intestine (HP:0002037)	2.18843778
97	Encephalitis (HP:0002383)	2.18750224
98	Amaurosis fugax (HP:0100576)	2.16631571
99	Basal cell carcinoma (HP:0002671)	2.16575979
100	Ragged-red muscle fibers (HP:0003200)	2.15141895
101	Abnormality of fatty-acid metabolism (HP:0004359)	2.15132806
102	Increased muscle lipid content (HP:0009058)	2.14940627
103	Gout (HP:0001997)	2.14618848
104	Hypochromic microcytic anemia (HP:0004840)	2.14418386
105	Prolonged partial thromboplastin time (HP:0003645)	2.13836062
106	Joint hemorrhage (HP:0005261)	2.13206038
107	Abnormality of iron homeostasis (HP:0011031)	2.12903697
108	Hyperammonemia (HP:0001987)	2.12542647
109	Hypoglycemic coma (HP:0001325)	2.12321511
110	Thrombophlebitis (HP:0004418)	2.11792424
111	Hyperglycinuria (HP:0003108)	2.11573039
112	Agammaglobulinemia (HP:0004432)	2.10734189
113	Abnormality of eosinophils (HP:0001879)	2.10066228
114	Amyloidosis (HP:0011034)	2.10034446
115	Increased intramyocellular lipid droplets (HP:0012240)	2.10007515
116	Lymphoma (HP:0002665)	2.09953152
117	Recurrent abscess formation (HP:0002722)	2.09685809
118	Xanthomatosis (HP:0000991)	2.08087673
119	Hypertensive crisis (HP:0100735)	2.07832239
120	Loss of speech (HP:0002371)	2.07568333
121	Hyperlipoproteinemia (HP:0010980)	2.07321096
122	Meningitis (HP:0001287)	2.06501363
123	Abnormal platelet volume (HP:0011876)	2.05773348
124	Vacuolated lymphocytes (HP:0001922)	2.05133059
125	Acne (HP:0001061)	2.04978633
126	Macrocytic anemia (HP:0001972)	2.04450999
127	Purpura (HP:0000979)	2.03540235
128	Pancytopenia (HP:0001876)	2.02701506
129	Abnormality of pyrimidine metabolism (HP:0004353)	2.02621888
130	Abnormality of the pleura (HP:0002103)	2.01573819
131	Increased cerebral lipofuscin (HP:0011813)	2.01377003
132	Colitis (HP:0002583)	1.99735613
133	Gangrene (HP:0100758)	1.99201273
134	Eosinophilia (HP:0001880)	1.98676673
135	Osteomyelitis (HP:0002754)	1.98467808
136	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.98111595
137	Skin ulcer (HP:0200042)	1.96828289
138	Autoimmune thrombocytopenia (HP:0001973)	1.96423872
139	Sepsis (HP:0100806)	1.96400602
140	Polygenic inheritance (HP:0010982)	1.96333431
141	Glomerulopathy (HP:0100820)	1.95006290
142	Menorrhagia (HP:0000132)	1.94992272
143	Abnormality of liposaccharide metabolism (HP:0010968)	1.94362750
144	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.94362750
145	Abnormality of glycolipid metabolism (HP:0010969)	1.94362750
146	Recurrent skin infections (HP:0001581)	1.93918462
147	Gastrointestinal stroma tumor (HP:0100723)	1.92838886
148	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.92786178
149	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.92207233
150	Deep venous thrombosis (HP:0002625)	1.90973101
151	Systemic lupus erythematosus (HP:0002725)	1.89943757
152	Ketosis (HP:0001946)	1.89491870
153	Acute hepatic failure (HP:0006554)	1.89287142
154	Arterial thrombosis (HP:0004420)	1.89007581
155	Abnormality of nucleobase metabolism (HP:0010932)	1.88895942
156	Hemorrhage of the eye (HP:0011885)	1.88862609
157	Eczematoid dermatitis (HP:0000976)	1.88105568

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K1	4.51014782
2	TXK	3.18419192
3	JAK3	3.17863004
4	NME2	3.14480655
5	RIPK4	3.09050678
6	KIT	2.81338679
7	PRPF4B	2.78436975
8	KDR	2.58762574
9	ZAP70	2.55943664
10	FGFR4	2.46244895
11	BTK	2.36173645
12	BCKDK	2.26639238
13	MAP2K3	2.12138320
14	TEC	2.08259234
15	TGFBR1	2.07246771
16	FLT3	2.04683069
17	IKBKE	2.03411086
18	TYK2	1.97654881
19	TGFBR2	1.93092625
20	EEF2K	1.90016843
21	EPHB1	1.81425985
22	SIK3	1.72176645
23	STK16	1.69080653
24	SYK	1.68885952
25	SIK1	1.65927862
26	TBK1	1.64383850
27	BLK	1.62473628
28	ITK	1.61008869
29	TIE1	1.60150280
30	NLK	1.59772109
31	TAOK1	1.59047193
32	STK10	1.56584338
33	SMG1	1.47173558
34	CSF1R	1.45444721
35	ACVR1B	1.42329220
36	GRK6	1.41962897
37	MAP3K14	1.41840765
38	LCK	1.33834958
39	JAK1	1.33578390
40	RIPK1	1.28272865
41	IKBKB	1.22902001
42	MAP2K6	1.22408141
43	ERN1	1.21381571
44	WEE1	1.20393048
45	PRKD2	1.19111361
46	PASK	1.16136139
47	TAOK3	1.12317457
48	LRRK2	1.12225391
49	PIM1	1.11406310
50	TAOK2	1.04651815
51	PTK6	1.04593317
52	RPS6KB2	1.04311388
53	PKN2	1.00930467
54	MARK2	0.99057996
55	LYN	0.97988804
56	IRAK4	0.95027819
57	MARK3	0.93732883
58	MAP3K10	0.92172505
59	MAP3K1	0.85782491
60	MAP3K3	0.84638900
61	JAK2	0.84350844
62	MAPK15	0.83297615
63	CDK19	0.82424506
64	SIK2	0.82106869
65	MAPK11	0.82006474
66	MST1R	0.81571578
67	TESK1	0.81197107
68	FGR	0.79891555
69	PDPK1	0.79205178
70	TESK2	0.77989530
71	MUSK	0.77617088
72	IRAK3	0.77161539
73	HCK	0.76412995
74	PIM2	0.75383943
75	CSK	0.73792924
76	FGFR3	0.73416338
77	MATK	0.72800164
78	CAMKK1	0.72129918
79	BMPR2	0.71522659
80	DYRK3	0.71352805
81	NEK2	0.70952021
82	MAP3K12	0.69599491
83	CDC42BPA	0.69470783
84	CHUK	0.68920465
85	MST4	0.67880306
86	RPS6KL1	0.64651898
87	RPS6KC1	0.64651898
88	DYRK1B	0.64583333
89	MAPK4	0.64206589
90	MAP3K11	0.63234096
91	MAPK12	0.62261747
92	PDK1	0.61994045
93	FES	0.61066578
94	EIF2AK3	0.60107403
95	MAPK7	0.59325715
96	CDK4	0.57997112
97	MAP3K8	0.57744830
98	NEK9	0.56701169
99	MAPKAPK3	0.56634150
100	FYN	0.56446966
101	BMX	0.55950819
102	TLK1	0.53607855
103	MAP3K13	0.53366172
104	TSSK6	0.51963765
105	VRK1	0.50908377
106	MAP3K7	0.50549261
107	EIF2AK1	0.50528485
108	MAP2K2	0.48744723
109	INSRR	0.47459155
110	PRKG2	0.46097553
111	ICK	0.43981952
112	IRAK2	0.43442171
113	EPHA2	0.43057851
114	STK38	0.42069441
115	ADRBK2	0.41913472
116	HIPK2	0.41793712
117	CSNK1G3	0.40973386
118	TRIB3	0.40404166
119	MAPKAPK2	0.38588820
120	GRK1	0.37942816
121	MYLK	0.37266206
122	CDK7	0.36731205
123	IRAK1	0.36473018
124	CSNK1G1	0.34233280
125	PRKD1	0.33672773
126	CSNK1A1L	0.33579666
127	YES1	0.33569537
128	ATR	0.33408951
129	AURKB	0.32949839
130	MAPK3	0.32203532
131	RPS6KA2	0.31759456
132	TNK2	0.31349436
133	PAK4	0.30814837
134	PRKCQ	0.30444171
135	STK4	0.29690616
136	MAP3K6	0.29619030
137	RPS6KA6	0.28761818
138	BUB1	0.27444625
139	PRKCH	0.26688229

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	3.72764385
2	Ribosome_Homo sapiens_hsa03010	2.88235975
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.82760303
4	DNA replication_Homo sapiens_hsa03030	2.25615425
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.16297349
6	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.09577402
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.02889796
8	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.90537897
9	Viral myocarditis_Homo sapiens_hsa05416	1.83756975
10	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.80371365
11	Selenocompound metabolism_Homo sapiens_hsa00450	1.79199327
12	Folate biosynthesis_Homo sapiens_hsa00790	1.76040220
13	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.71939678
14	Asthma_Homo sapiens_hsa05310	1.70125480
15	Tuberculosis_Homo sapiens_hsa05152	1.63251372
16	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.63173463
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.59607292
18	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.57859869
19	Measles_Homo sapiens_hsa05162	1.56622411
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.54143505
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53952165
22	Fatty acid degradation_Homo sapiens_hsa00071	1.53441046
23	Antigen processing and presentation_Homo sapiens_hsa04612	1.52808583
24	Caffeine metabolism_Homo sapiens_hsa00232	1.52750166
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.52050753
26	Mismatch repair_Homo sapiens_hsa03430	1.52044328
27	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.49949486
28	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.49486867
29	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.49288662
30	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.48999489
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.48137122
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.47100241
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.46408118
34	Base excision repair_Homo sapiens_hsa03410	1.42209336
35	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.42043024
36	Malaria_Homo sapiens_hsa05144	1.38904453
37	Toxoplasmosis_Homo sapiens_hsa05145	1.35975050
38	Pentose phosphate pathway_Homo sapiens_hsa00030	1.35302945
39	Chemokine signaling pathway_Homo sapiens_hsa04062	1.33003308
40	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.31464727
41	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.31334885
42	Sulfur relay system_Homo sapiens_hsa04122	1.29496621
43	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.27871506
44	One carbon pool by folate_Homo sapiens_hsa00670	1.24206674
45	Peroxisome_Homo sapiens_hsa04146	1.20662143
46	TNF signaling pathway_Homo sapiens_hsa04668	1.19408457
47	beta-Alanine metabolism_Homo sapiens_hsa00410	1.19383902
48	Proteasome_Homo sapiens_hsa03050	1.19346578
49	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.17514299
50	Pyrimidine metabolism_Homo sapiens_hsa00240	1.16792882
51	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.13027180
52	Hepatitis C_Homo sapiens_hsa05160	1.12680698
53	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.11781718
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.10925705
55	Complement and coagulation cascades_Homo sapiens_hsa04610	1.10461208
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.08825061
57	Leishmaniasis_Homo sapiens_hsa05140	1.08624242
58	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	1.08375479
59	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.06880169
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.06467266
61	Other glycan degradation_Homo sapiens_hsa00511	1.06312879
62	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.06177013
63	Herpes simplex infection_Homo sapiens_hsa05168	1.05854722
64	Histidine metabolism_Homo sapiens_hsa00340	1.05756261
65	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.04545752
66	RNA polymerase_Homo sapiens_hsa03020	1.03869138
67	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.03590724
68	VEGF signaling pathway_Homo sapiens_hsa04370	1.02276571
69	Arginine biosynthesis_Homo sapiens_hsa00220	1.01417087
70	Platelet activation_Homo sapiens_hsa04611	1.00991857
71	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00717690
72	Non-small cell lung cancer_Homo sapiens_hsa05223	0.99753641
73	Spliceosome_Homo sapiens_hsa03040	0.99685091
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98748316
75	Hepatitis B_Homo sapiens_hsa05161	0.97732686
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.94535694
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93824856
78	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.93777979
79	Allograft rejection_Homo sapiens_hsa05330	0.93564680
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.93428178
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93402973
82	Pertussis_Homo sapiens_hsa05133	0.93373284
83	Nucleotide excision repair_Homo sapiens_hsa03420	0.93200951
84	ABC transporters_Homo sapiens_hsa02010	0.92086406
85	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.91657195
86	Propanoate metabolism_Homo sapiens_hsa00640	0.90477806
87	Homologous recombination_Homo sapiens_hsa03440	0.89992949
88	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.88499411
89	Carbon metabolism_Homo sapiens_hsa01200	0.87951436
90	Lysosome_Homo sapiens_hsa04142	0.84168140
91	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.83282479
92	Notch signaling pathway_Homo sapiens_hsa04330	0.83066698
93	African trypanosomiasis_Homo sapiens_hsa05143	0.82295354
94	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.80219218
95	Endocytosis_Homo sapiens_hsa04144	0.79060538
96	Pancreatic cancer_Homo sapiens_hsa05212	0.78158954
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.77568429
98	HTLV-I infection_Homo sapiens_hsa05166	0.76530859
99	Galactose metabolism_Homo sapiens_hsa00052	0.73485333
100	Phagosome_Homo sapiens_hsa04145	0.72912768
101	Acute myeloid leukemia_Homo sapiens_hsa05221	0.72796525
102	p53 signaling pathway_Homo sapiens_hsa04115	0.72442878
103	Butanoate metabolism_Homo sapiens_hsa00650	0.71806830
104	Choline metabolism in cancer_Homo sapiens_hsa05231	0.70290584
105	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.70111715
106	Salmonella infection_Homo sapiens_hsa05132	0.69944986
107	Insulin resistance_Homo sapiens_hsa04931	0.67428008
108	Nitrogen metabolism_Homo sapiens_hsa00910	0.67155952
109	Non-homologous end-joining_Homo sapiens_hsa03450	0.66772109
110	Retinol metabolism_Homo sapiens_hsa00830	0.66436247
111	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.66044975
112	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65747886
113	Shigellosis_Homo sapiens_hsa05131	0.65722631
114	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.64680250
115	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.63278197
116	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.62278221
117	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.62118839
118	Osteoclast differentiation_Homo sapiens_hsa04380	0.61522457
119	Pyruvate metabolism_Homo sapiens_hsa00620	0.60880385
120	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.59943257
121	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.58685538
122	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.58083986
123	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57957137
124	Glutathione metabolism_Homo sapiens_hsa00480	0.56418449
125	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56192631
126	Viral carcinogenesis_Homo sapiens_hsa05203	0.56104236
127	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.55974451
128	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.55570187
129	Sulfur metabolism_Homo sapiens_hsa00920	0.54910121
130	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54136878
131	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.53761460
132	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.53457194
133	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.52832554
134	PPAR signaling pathway_Homo sapiens_hsa03320	0.52005238
135	mTOR signaling pathway_Homo sapiens_hsa04150	0.51889129
136	Fatty acid metabolism_Homo sapiens_hsa01212	0.51655540
137	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50359251
138	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49900133
139	Legionellosis_Homo sapiens_hsa05134	0.49789125
140	Influenza A_Homo sapiens_hsa05164	0.49484657
141	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.49359400
142	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.48905172
143	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.48257096
144	Fatty acid elongation_Homo sapiens_hsa00062	0.48178722
145	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.47909407
146	Lysine degradation_Homo sapiens_hsa00310	0.47740135
147	Graft-versus-host disease_Homo sapiens_hsa05332	0.47130418
148	Fanconi anemia pathway_Homo sapiens_hsa03460	0.46732968
149	Regulation of autophagy_Homo sapiens_hsa04140	0.46635209
150	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.46306143
151	Colorectal cancer_Homo sapiens_hsa05210	0.45991033
152	Apoptosis_Homo sapiens_hsa04210	0.45934570
153	RNA degradation_Homo sapiens_hsa03018	0.45795249
154	Prolactin signaling pathway_Homo sapiens_hsa04917	0.45108612
155	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.44866746
156	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.44497240
157	Endometrial cancer_Homo sapiens_hsa05213	0.38167461
158	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.36929686
159	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.35766418
160	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.33483587
161	FoxO signaling pathway_Homo sapiens_hsa04068	0.32186585
162	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.29604944
163	Renal cell carcinoma_Homo sapiens_hsa05211	0.28230792
164	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.27914703
165	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.27183812
166	MAPK signaling pathway_Homo sapiens_hsa04010	0.27075134

SIGIRR

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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