SIGLEC10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.24577472
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.98708922
3negative regulation of cell killing (GO:0031342)5.98708922
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.66987116
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.47573797
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.47573797
7modulation by symbiont of host immune response (GO:0052553)5.47573797
8positive regulation by symbiont of host defense response (GO:0052509)5.47573797
9modulation by symbiont of host defense response (GO:0052031)5.47573797
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.47573797
11antigen processing and presentation of endogenous antigen (GO:0019883)5.36821919
12regulation of B cell receptor signaling pathway (GO:0050855)5.25595275
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.21705980
14neutrophil activation involved in immune response (GO:0002283)5.09750824
15macrophage activation involved in immune response (GO:0002281)4.96165479
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.77150192
17regulation of interferon-beta biosynthetic process (GO:0045357)4.65105656
18regulation of gamma-delta T cell activation (GO:0046643)4.55883334
19detection of other organism (GO:0098543)4.55688524
20cellular extravasation (GO:0045123)4.51599420
21response to peptidoglycan (GO:0032494)4.48137557
22detection of bacterium (GO:0016045)4.37470970
23immunoglobulin mediated immune response (GO:0016064)4.35300322
24negative regulation of interleukin-12 production (GO:0032695)4.25136164
25B cell receptor signaling pathway (GO:0050853)4.20266124
26neutrophil activation (GO:0042119)4.12875134
27negative regulation of lymphocyte mediated immunity (GO:0002707)4.11859989
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.07008254
29regulation of gamma-delta T cell differentiation (GO:0045586)4.03641552
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.97444456
31microglial cell activation (GO:0001774)3.96687173
32positive regulation of mast cell activation (GO:0033005)3.96655843
33respiratory burst (GO:0045730)3.95324935
34detection of external biotic stimulus (GO:0098581)3.94945783
35regulation of mast cell degranulation (GO:0043304)3.92073373
36positive regulation of B cell differentiation (GO:0045579)3.88860829
37detection of molecule of bacterial origin (GO:0032490)3.87620590
38response to host immune response (GO:0052572)3.84050903
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.84050903
40regulation of mast cell activation (GO:0033003)3.82512801
41myeloid cell activation involved in immune response (GO:0002275)3.81041099
42regulation of B cell differentiation (GO:0045577)3.80064812
43granulocyte activation (GO:0036230)3.73942699
44regulation of mast cell activation involved in immune response (GO:0033006)3.72250882
45leukocyte aggregation (GO:0070486)3.70078422
46macrophage activation (GO:0042116)3.64491992
47negative regulation of leukocyte mediated immunity (GO:0002704)3.62753411
48positive thymic T cell selection (GO:0045059)3.60685946
49germinal center formation (GO:0002467)3.58912984
50negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.58094967
51positive regulation of mast cell degranulation (GO:0043306)3.56492321
52positive regulation of mast cell activation involved in immune response (GO:0033008)3.56492321
53production of molecular mediator involved in inflammatory response (GO:0002532)3.55958994
54response to interleukin-15 (GO:0070672)3.55495864
55regulation of myeloid leukocyte mediated immunity (GO:0002886)3.53722743
56negative regulation of T cell mediated immunity (GO:0002710)3.52673578
57defense response to protozoan (GO:0042832)3.50171572
58detection of biotic stimulus (GO:0009595)3.48377734
59leukocyte migration involved in inflammatory response (GO:0002523)3.48119684
60cellular response to type I interferon (GO:0071357)3.47553855
61type I interferon signaling pathway (GO:0060337)3.47553855
62response to type I interferon (GO:0034340)3.46525298
63B cell mediated immunity (GO:0019724)3.41590863
64response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.39212672
65response to host (GO:0075136)3.39212672
66response to host defenses (GO:0052200)3.39212672
67negative thymic T cell selection (GO:0045060)3.34860934
68interferon-gamma-mediated signaling pathway (GO:0060333)3.34835660
69neutrophil mediated immunity (GO:0002446)3.30298514
70regulation of antigen processing and presentation (GO:0002577)3.30064363
71leukocyte degranulation (GO:0043299)3.29343938
72cellular response to interleukin-15 (GO:0071350)3.28317986
73regulation of dendritic cell antigen processing and presentation (GO:0002604)3.27839922
74positive regulation of antigen processing and presentation (GO:0002579)3.26595637
75regulation of leukocyte degranulation (GO:0043300)3.22832522
76negative T cell selection (GO:0043383)3.22531019
77antigen processing and presentation via MHC class Ib (GO:0002475)3.21969369
78negative regulation of T-helper cell differentiation (GO:0045623)3.17696986
79negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17696986
80activated T cell proliferation (GO:0050798)3.15391378
81positive regulation of interferon-alpha production (GO:0032727)3.13520866
82positive T cell selection (GO:0043368)3.12470941
83response to protozoan (GO:0001562)3.11124029
84positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.09883006
85negative regulation of phagocytosis (GO:0050765)3.08376964
86regulation of T cell mediated cytotoxicity (GO:0001914)3.06187766
87regulation of interferon-alpha production (GO:0032647)3.03679393
88regulation of T cell tolerance induction (GO:0002664)3.03205441
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02587085
90negative regulation of alpha-beta T cell activation (GO:0046636)3.01494373
91negative regulation of interleukin-6 production (GO:0032715)3.00822627
92regulation of tolerance induction (GO:0002643)3.00075033
93T cell selection (GO:0045058)2.99765174
94response to muramyl dipeptide (GO:0032495)2.98934377
95positive regulation of T cell mediated cytotoxicity (GO:0001916)2.98701397
96positive regulation of toll-like receptor signaling pathway (GO:0034123)2.98490739
97regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97987731
98regulation of alpha-beta T cell proliferation (GO:0046640)2.96941024
99negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.94275392
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91866560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.60973362
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.95552934
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.56523145
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.02224596
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.54140186
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.38295248
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.35482931
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.35153901
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.28531026
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.14107536
11RUNX_20019798_ChIP-Seq_JUKART_Human2.88786381
12* SPI1_23547873_ChIP-Seq_NB4_Human2.68632034
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58205481
14SPI1_23127762_ChIP-Seq_K562_Human2.56338487
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50623902
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.45186619
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.39251796
18MYB_26560356_Chip-Seq_TH2_Human2.34416302
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34085344
20SCL_19346495_ChIP-Seq_HPC-7_Human2.33718098
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30283801
22VDR_24763502_ChIP-Seq_THP-1_Human2.27802679
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26081763
24VDR_21846776_ChIP-Seq_THP-1_Human2.07110201
25MYC_22102868_ChIP-Seq_BL_Human2.06422451
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05850745
27VDR_24787735_ChIP-Seq_THP-1_Human2.02685344
28MAF_26560356_Chip-Seq_TH1_Human1.96861509
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93298110
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.91965784
31MYB_26560356_Chip-Seq_TH1_Human1.91237636
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87867872
33GATA3_27048872_Chip-Seq_THYMUS_Human1.81320236
34* UTX_26944678_Chip-Seq_JUKART_Human1.79096596
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76248328
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74551517
37GATA3_26560356_Chip-Seq_TH2_Human1.66715341
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65125884
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64298418
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63707619
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.55285182
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48414322
43MAF_26560356_Chip-Seq_TH2_Human1.46802338
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46191677
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43992671
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42671827
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.42183049
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38912548
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38438565
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36184506
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35509736
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32437559
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32066558
54VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28752680
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28457198
56TCF7_22412390_ChIP-Seq_EML_Mouse1.24843339
57PU_27001747_Chip-Seq_BMDM_Mouse1.21583444
58GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20577150
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17511220
60CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15335184
61KDM2B_26808549_Chip-Seq_DND41_Human1.14877909
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13759386
63GATA1_22025678_ChIP-Seq_K562_Human1.12625945
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11995936
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.11417141
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11362612
67SMRT_27268052_Chip-Seq_Bcells_Human1.11056561
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10946896
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09421323
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09159453
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08258748
72BCL6_27268052_Chip-Seq_Bcells_Human1.06741244
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05354717
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02825797
75GATA1_19941826_ChIP-Seq_K562_Human0.99643753
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96920721
77NOTCH1_21737748_ChIP-Seq_TLL_Human0.95703806
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94694022
79BCOR_27268052_Chip-Seq_Bcells_Human0.94528512
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94433558
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93469132
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89273108
83PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89077079
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88124943
85GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87938132
86GATA2_19941826_ChIP-Seq_K562_Human0.87752701
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85683490
88GATA2_21666600_ChIP-Seq_HMVEC_Human0.85185037
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84948936
90RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83163620
91ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82333737
92SPI1_20517297_ChIP-Seq_HL60_Human0.80558188
93P300_27268052_Chip-Seq_Bcells_Human0.78771996
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74341035
95* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73974182
96DROSHA_22980978_ChIP-Seq_HELA_Human0.73576202
97GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72645306
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.72572582
99BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.72098212
100GATA3_26560356_Chip-Seq_TH1_Human0.71107370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.30337217
2MP0003724_increased_susceptibility_to4.29051697
3MP0003436_decreased_susceptibility_to3.90568683
4MP0003303_peritoneal_inflammation3.79438398
5MP0005671_abnormal_response_to3.38516233
6MP0001800_abnormal_humoral_immune3.35462623
7MP0005387_immune_system_phenotype3.29024758
8MP0001790_abnormal_immune_system3.29024758
9MP0002419_abnormal_innate_immunity3.08723767
10MP0005000_abnormal_immune_tolerance3.05473287
11MP0000685_abnormal_immune_system2.98842107
12MP0009785_altered_susceptibility_to2.93924802
13MP0005025_abnormal_response_to2.90068044
14MP0002723_abnormal_immune_serum2.82304573
15MP0002452_abnormal_antigen_presenting2.80558565
16MP0002420_abnormal_adaptive_immunity2.66632335
17MP0001819_abnormal_immune_cell2.64071941
18MP0006082_CNS_inflammation2.50959712
19MP0002148_abnormal_hypersensitivity_rea2.45696560
20MP0001986_abnormal_taste_sensitivity2.24533200
21MP0003763_abnormal_thymus_physiology2.19015899
22MP0002405_respiratory_system_inflammati2.04385594
23MP0003300_gastrointestinal_ulcer2.02358731
24MP0005464_abnormal_platelet_physiology1.99592200
25MP0002398_abnormal_bone_marrow1.97473472
26MP0000716_abnormal_immune_system1.97013991
27MP0005310_abnormal_salivary_gland1.93161150
28MP0001533_abnormal_skeleton_physiology1.88122295
29MP0003172_abnormal_lysosome_physiology1.87076790
30MP0001845_abnormal_inflammatory_respons1.85100057
31MP0010155_abnormal_intestine_physiology1.75569066
32MP0000689_abnormal_spleen_morphology1.73202375
33MP0000465_gastrointestinal_hemorrhage1.69246363
34MP0003191_abnormal_cellular_cholesterol1.69190184
35MP0009764_decreased_sensitivity_to1.66055238
36MP0002722_abnormal_immune_system1.58090998
37MP0009278_abnormal_bone_marrow1.54052056
38MP0003866_abnormal_defecation1.53114303
39MP0002429_abnormal_blood_cell1.52399988
40MP0002132_abnormal_respiratory_system1.48352322
41MP0008469_abnormal_protein_level1.47981148
42MP0002396_abnormal_hematopoietic_system1.44513286
43MP0004947_skin_inflammation1.42886079
44MP0004381_abnormal_hair_follicle1.38653689
45MP0003183_abnormal_peptide_metabolism1.36347374
46MP0003828_pulmonary_edema1.29836541
47MP0009333_abnormal_splenocyte_physiolog1.29746047
48MP0008260_abnormal_autophagy1.29163963
49MP0000703_abnormal_thymus_morphology1.27875301
50MP0005075_abnormal_melanosome_morpholog1.26550556
51MP0002277_abnormal_respiratory_mucosa1.20904241
52MP0004883_abnormal_blood_vessel1.17336214
53MP0005397_hematopoietic_system_phenotyp1.16779281
54MP0001545_abnormal_hematopoietic_system1.16779281
55MP0002138_abnormal_hepatobiliary_system1.12023143
56MP0003690_abnormal_glial_cell1.06927704
57MP0003075_altered_response_to1.05761840
58MP0005451_abnormal_body_composition1.04382430
59MP0002998_abnormal_bone_remodeling0.97306788
60MP0000569_abnormal_digit_pigmentation0.97001849
61MP0002166_altered_tumor_susceptibility0.96468495
62MP0005166_decreased_susceptibility_to0.96305295
63MP0001853_heart_inflammation0.93003031
64MP0000015_abnormal_ear_pigmentation0.92147582
65MP0000343_altered_response_to0.91189281
66MP0005167_abnormal_blood-brain_barrier0.90154201
67MP0001663_abnormal_digestive_system0.88765102
68MP0004510_myositis0.86441923
69MP0001873_stomach_inflammation0.86204059
70MP0008004_abnormal_stomach_pH0.84156713
71MP0003787_abnormal_imprinting0.83739253
72MP0001851_eye_inflammation0.83638714
73MP0009763_increased_sensitivity_to0.80814128
74MP0000858_altered_metastatic_potential0.80218103
75MP0005164_abnormal_response_to0.77754526
76MP0003252_abnormal_bile_duct0.75857337
77MP0005058_abnormal_lysosome_morphology0.73173582
78MP0002928_abnormal_bile_duct0.71394778
79MP0009765_abnormal_xenobiotic_induced0.70693018
80MP0000604_amyloidosis0.68691625
81MP0003045_fibrosis0.67164959
82MP0000249_abnormal_blood_vessel0.66397019
83MP0003448_altered_tumor_morphology0.64437838
84MP0002693_abnormal_pancreas_physiology0.63736608
85MP0003195_calcinosis0.63725863
86MP0005174_abnormal_tail_pigmentation0.62809749
87MP0008874_decreased_physiological_sensi0.61920995
88MP0004808_abnormal_hematopoietic_stem0.61635004
89MP0003656_abnormal_erythrocyte_physiolo0.60330640
90MP0002006_tumorigenesis0.58910157
91MP0005390_skeleton_phenotype0.58781696
92MP0002653_abnormal_ependyma_morphology0.58377471
93MP0005084_abnormal_gallbladder_morpholo0.57783105
94MP0000490_abnormal_crypts_of0.57591429
95MP0000371_diluted_coat_color0.54609440
96MP0003646_muscle_fatigue0.53328703
97MP0002933_joint_inflammation0.53294328
98MP0002332_abnormal_exercise_endurance0.52708603
99MP0005377_hearing/vestibular/ear_phenot0.49039488
100MP0003878_abnormal_ear_physiology0.49039488

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.04672186
2Eczematoid dermatitis (HP:0000976)5.98862527
3Recurrent abscess formation (HP:0002722)5.96714253
4Myositis (HP:0100614)5.35709160
5Abnormality of macrophages (HP:0004311)5.15420094
6Orchitis (HP:0100796)5.02259799
7Optic neuritis (HP:0100653)4.96028579
8Retrobulbar optic neuritis (HP:0100654)4.96028579
9Stomatitis (HP:0010280)4.92929696
10Recurrent gram-negative bacterial infections (HP:0005420)4.64106393
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.59335339
12Elevated erythrocyte sedimentation rate (HP:0003565)4.49641659
13Mediastinal lymphadenopathy (HP:0100721)4.46227426
14Recurrent fungal infections (HP:0002841)4.42336471
15Meningitis (HP:0001287)4.42141449
16Recurrent cutaneous fungal infections (HP:0011370)4.22509239
17Chronic mucocutaneous candidiasis (HP:0002728)4.22509239
18Recurrent skin infections (HP:0001581)4.18959442
19Chronic obstructive pulmonary disease (HP:0006510)4.04481974
20Obstructive lung disease (HP:0006536)4.04481974
21Encephalitis (HP:0002383)3.92037753
22Gastrointestinal infarctions (HP:0005244)3.81940929
23Vasculitis (HP:0002633)3.81888708
24Spontaneous hematomas (HP:0007420)3.58759154
25Keratoconjunctivitis sicca (HP:0001097)3.45156641
26Hemoptysis (HP:0002105)3.40951951
27Panhypogammaglobulinemia (HP:0003139)3.34268857
28Keratoconjunctivitis (HP:0001096)3.31271429
29Gingivitis (HP:0000230)3.28109925
30Urticaria (HP:0001025)3.20510256
31Prolonged bleeding time (HP:0003010)3.20425019
32Pulmonary infiltrates (HP:0002113)3.17214684
33Chest pain (HP:0100749)3.15542869
34T lymphocytopenia (HP:0005403)3.11974808
35Abnormality of T cell number (HP:0011839)3.10441952
36Agammaglobulinemia (HP:0004432)3.10322151
37Inflammation of the large intestine (HP:0002037)3.07253882
38Recurrent viral infections (HP:0004429)2.99440210
39Increased IgE level (HP:0003212)2.98258475
40Episodic fever (HP:0001954)2.92017518
41Cellulitis (HP:0100658)2.91127765
42Gastrointestinal inflammation (HP:0004386)2.89450819
43Abnormality of T cells (HP:0002843)2.89061664
44Leukocytosis (HP:0001974)2.85519138
45Pustule (HP:0200039)2.81107054
46Hypochromic anemia (HP:0001931)2.76672340
47Lymphopenia (HP:0001888)2.74647212
48Hypochromic microcytic anemia (HP:0004840)2.72478822
49Chronic otitis media (HP:0000389)2.69029871
50Recurrent bronchitis (HP:0002837)2.65858800
51Gingival bleeding (HP:0000225)2.64598221
52Osteomyelitis (HP:0002754)2.64181564
53Colitis (HP:0002583)2.61712736
54Anorexia (HP:0002039)2.61464576
55Pulmonary embolism (HP:0002204)2.61462448
56Abnormality of the pleura (HP:0002103)2.59488546
57Epistaxis (HP:0000421)2.57799771
58Arterial thrombosis (HP:0004420)2.56548924
59Increased cerebral lipofuscin (HP:0011813)2.56535724
60Abnormality of T cell physiology (HP:0011840)2.53990771
61Increased IgM level (HP:0003496)2.53235334
62Gastrointestinal stroma tumor (HP:0100723)2.53182267
63Abnormality of cells of the lymphoid lineage (HP:0012140)2.52248208
64Petechiae (HP:0000967)2.48497575
65Recurrent sinusitis (HP:0011108)2.44762911
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.37163019
67Sepsis (HP:0100806)2.36398382
68Granulocytopenia (HP:0001913)2.35810451
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33009682
70Gangrene (HP:0100758)2.25405805
71Recurrent pneumonia (HP:0006532)2.21958246
72Amyloidosis (HP:0011034)2.16115461
73Eosinophilia (HP:0001880)2.13371438
74Neoplasm of the tracheobronchial system (HP:0100552)2.10576460
75Viral hepatitis (HP:0006562)2.10153612
76Abnormality of the peritoneum (HP:0002585)2.10062055
77Alveolar cell carcinoma (HP:0006519)2.09537263
78Hematochezia (HP:0002573)2.08626416
79Restrictive lung disease (HP:0002091)2.07561744
80IgG deficiency (HP:0004315)2.06590212
81Abnormality of the prostate (HP:0008775)2.06365879
82Autoimmune thrombocytopenia (HP:0001973)2.06179919
83IgM deficiency (HP:0002850)2.04905936
84Microcytic anemia (HP:0001935)2.04772186
85Abnormality of the endocardium (HP:0004306)2.03780444
86Vertigo (HP:0002321)2.02486256
87Purpura (HP:0000979)2.02280221
88Stomach cancer (HP:0012126)2.01612327
89Skin rash (HP:0000988)2.00451138
90Loss of speech (HP:0002371)1.99996470
91Abnormality of eosinophils (HP:0001879)1.97786850
92Polyneuropathy (HP:0001271)1.96101473
93Systemic lupus erythematosus (HP:0002725)1.95703878
94Keratitis (HP:0000491)1.95352020
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95087365
96Recurrent lower respiratory tract infections (HP:0002783)1.93599228
97Vacuolated lymphocytes (HP:0001922)1.93101255
98Hypergammaglobulinemia (HP:0010702)1.92769951
99Cheilitis (HP:0100825)1.92235087
100Verrucae (HP:0200043)1.89906261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.64562390
2BLK4.58497835
3MAP4K14.55675373
4IRAK43.20444232
5TYK22.97562035
6ERN12.89525263
7FES2.59354050
8CSK2.52988653
9TNK22.34566372
10MAP2K32.22379457
11BTK2.10882316
12SYK2.08045722
13TXK1.97126135
14GRK61.93101602
15MAP3K141.89450499
16CSF1R1.88332359
17FGR1.80625821
18ZAP701.76834097
19IKBKE1.76317215
20TAOK31.76101288
21LYN1.66665918
22HCK1.60585877
23TEC1.54472910
24MAP3K131.48623659
25KIT1.43233714
26TAOK11.42679732
27JAK11.35840782
28* JAK31.33512220
29JAK21.32300664
30EPHB11.28344410
31MAP3K111.27915379
32ACVR1B1.25157057
33FRK1.22936254
34MARK31.22605236
35IRAK11.21548511
36MATK1.20128586
37TBK11.19212731
38MAP3K31.18893433
39* LCK1.17375562
40IKBKB1.11756558
41SIK31.04185267
42PRPF4B1.02558978
43PDK11.00766957
44PIK3CG0.99241637
45BMPR20.91386031
46* ITK0.89630421
47MAP3K10.89403855
48IRAK20.85704531
49YES10.82796142
50SIK20.80100592
51OXSR10.78237445
52KSR20.76548038
53CDK190.75830692
54PRKCQ0.71931515
55ADRBK20.69716788
56MAPK120.67791075
57PTK2B0.67704248
58GRK70.67627040
59DAPK20.67536861
60MARK20.67375541
61STK110.66959015
62PDPK10.66057999
63TGFBR20.63417255
64STK100.61928888
65PTK60.57775285
66MAPK70.57446457
67PRKD20.56247660
68CDC42BPA0.56100292
69* FYN0.54019845
70MAP3K50.52584806
71CAMKK20.51636492
72MAP2K40.50401952
73NLK0.49866185
74CAMK1D0.47042524
75HIPK20.44962546
76MAP3K70.44890317
77ABL10.43963846
78PIM10.43775320
79MAP2K60.39659325
80EPHA30.39547272
81SGK20.39272475
82SGK30.38713366
83PRKCZ0.37944141
84RPS6KA60.37273974
85FGFR30.35954964
86LRRK20.35490571
87TAOK20.35367092
88MAP3K20.34215292
89RPS6KL10.33038384
90RPS6KC10.33038384
91MAP2K20.30708840
92MAPKAPK20.30348993
93CAMKK10.28988581
94ADRBK10.28028515
95CAMK40.27800175
96MAP3K60.25343628
97PRKCD0.23086062
98NEK90.22673377
99CHUK0.22506830
100INSR0.22458297

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.33777785
2Leishmaniasis_Homo sapiens_hsa051403.11707262
3Allograft rejection_Homo sapiens_hsa053302.99198026
4Graft-versus-host disease_Homo sapiens_hsa053322.96993316
5Osteoclast differentiation_Homo sapiens_hsa043802.85692414
6Autoimmune thyroid disease_Homo sapiens_hsa053202.76070522
7Primary immunodeficiency_Homo sapiens_hsa053402.63147056
8B cell receptor signaling pathway_Homo sapiens_hsa046622.57123673
9Tuberculosis_Homo sapiens_hsa051522.32575204
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29869008
11Type I diabetes mellitus_Homo sapiens_hsa049402.28419429
12Asthma_Homo sapiens_hsa053102.25406737
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.25022357
14Hematopoietic cell lineage_Homo sapiens_hsa046402.04066221
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.03926781
16Antigen processing and presentation_Homo sapiens_hsa046121.98699852
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.95093175
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93483952
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86217106
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.78834507
21Measles_Homo sapiens_hsa051621.70527606
22Chemokine signaling pathway_Homo sapiens_hsa040621.62363922
23Malaria_Homo sapiens_hsa051441.61835945
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59723565
25Viral myocarditis_Homo sapiens_hsa054161.55971848
26Toxoplasmosis_Homo sapiens_hsa051451.53568751
27T cell receptor signaling pathway_Homo sapiens_hsa046601.49532680
28Influenza A_Homo sapiens_hsa051641.48766658
29Herpes simplex infection_Homo sapiens_hsa051681.45631703
30Phagosome_Homo sapiens_hsa041451.40993141
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38344634
32Rheumatoid arthritis_Homo sapiens_hsa053231.36843927
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.35711520
34Legionellosis_Homo sapiens_hsa051341.30705061
35African trypanosomiasis_Homo sapiens_hsa051431.25594924
36Acute myeloid leukemia_Homo sapiens_hsa052211.25054175
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23106941
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18174306
39TNF signaling pathway_Homo sapiens_hsa046681.10996329
40Platelet activation_Homo sapiens_hsa046111.10775878
41Pertussis_Homo sapiens_hsa051331.10007790
42Other glycan degradation_Homo sapiens_hsa005111.06969276
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97965910
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96132054
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94503890
46Hepatitis C_Homo sapiens_hsa051600.92143959
47Hepatitis B_Homo sapiens_hsa051610.90316692
48Lysosome_Homo sapiens_hsa041420.86774977
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83538923
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79114183
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.78575877
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78332937
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72921128
54Apoptosis_Homo sapiens_hsa042100.71452443
55Non-small cell lung cancer_Homo sapiens_hsa052230.71398847
56Dorso-ventral axis formation_Homo sapiens_hsa043200.66176479
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65519356
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.63595429
59Epstein-Barr virus infection_Homo sapiens_hsa051690.62687038
60Notch signaling pathway_Homo sapiens_hsa043300.61891926
61Salmonella infection_Homo sapiens_hsa051320.61876243
62Prolactin signaling pathway_Homo sapiens_hsa049170.61406692
63Regulation of autophagy_Homo sapiens_hsa041400.60560108
64Shigellosis_Homo sapiens_hsa051310.58702139
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54545237
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.54386930
67FoxO signaling pathway_Homo sapiens_hsa040680.51263146
68VEGF signaling pathway_Homo sapiens_hsa043700.50276075
69Pancreatic cancer_Homo sapiens_hsa052120.48463672
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.47920578
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.47150426
72Endocytosis_Homo sapiens_hsa041440.44328924
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43170089
74Choline metabolism in cancer_Homo sapiens_hsa052310.42521010
75Type II diabetes mellitus_Homo sapiens_hsa049300.41999454
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40641981
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.40219643
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39266650
79Renal cell carcinoma_Homo sapiens_hsa052110.38342254
80Viral carcinogenesis_Homo sapiens_hsa052030.37011262
81HTLV-I infection_Homo sapiens_hsa051660.36634476
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.36588309
83Chronic myeloid leukemia_Homo sapiens_hsa052200.36434661
84Arachidonic acid metabolism_Homo sapiens_hsa005900.35220971
85mTOR signaling pathway_Homo sapiens_hsa041500.35187714
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34665942
87GnRH signaling pathway_Homo sapiens_hsa049120.34530107
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34195390
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34110875
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34052680
91MAPK signaling pathway_Homo sapiens_hsa040100.33725647
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33223555
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32200720
94Collecting duct acid secretion_Homo sapiens_hsa049660.31064536
95Inositol phosphate metabolism_Homo sapiens_hsa005620.30957707
96Insulin resistance_Homo sapiens_hsa049310.30370884
97ABC transporters_Homo sapiens_hsa020100.30045774
98HIF-1 signaling pathway_Homo sapiens_hsa040660.29110549
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24459911
100Ether lipid metabolism_Homo sapiens_hsa005650.24347286

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