SIGLEC11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.14017921
2DNA deamination (GO:0045006)4.42724020
3L-fucose metabolic process (GO:0042354)4.42133254
4L-fucose catabolic process (GO:0042355)4.42133254
5fucose catabolic process (GO:0019317)4.42133254
6estrogen biosynthetic process (GO:0006703)4.28990029
7water-soluble vitamin biosynthetic process (GO:0042364)4.09058057
8piRNA metabolic process (GO:0034587)4.06566932
9cellular response to ATP (GO:0071318)3.90100168
10negative regulation of telomere maintenance (GO:0032205)3.63991959
11axoneme assembly (GO:0035082)3.45979656
12cellular ketone body metabolic process (GO:0046950)3.43149579
13platelet dense granule organization (GO:0060155)3.41236676
14detection of light stimulus involved in sensory perception (GO:0050962)3.40486520
15detection of light stimulus involved in visual perception (GO:0050908)3.40486520
16respiratory chain complex IV assembly (GO:0008535)3.38163510
17indolalkylamine metabolic process (GO:0006586)3.29943553
18ketone body metabolic process (GO:1902224)3.18395178
19tryptophan catabolic process (GO:0006569)3.14307028
20indole-containing compound catabolic process (GO:0042436)3.14307028
21indolalkylamine catabolic process (GO:0046218)3.14307028
22positive regulation of defense response to virus by host (GO:0002230)3.11537997
23cytochrome complex assembly (GO:0017004)3.07755029
24adaptation of signaling pathway (GO:0023058)3.06367713
25androgen biosynthetic process (GO:0006702)3.00154871
26purinergic nucleotide receptor signaling pathway (GO:0035590)2.96622178
27S-adenosylmethionine metabolic process (GO:0046500)2.95070484
28inositol phosphate catabolic process (GO:0071545)2.94899577
29negative regulation of mast cell activation (GO:0033004)2.94882249
30DNA methylation involved in gamete generation (GO:0043046)2.94742419
31negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93217607
32cilium or flagellum-dependent cell motility (GO:0001539)2.91639217
33epithelial cilium movement (GO:0003351)2.90026903
34sulfation (GO:0051923)2.89842770
35protein localization to cilium (GO:0061512)2.89815450
36protein-cofactor linkage (GO:0018065)2.87433907
37benzene-containing compound metabolic process (GO:0042537)2.85447697
383-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.85155375
39purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.85155375
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84723133
41photoreceptor cell maintenance (GO:0045494)2.80702788
42tryptophan metabolic process (GO:0006568)2.80529552
43response to pheromone (GO:0019236)2.79657604
44preassembly of GPI anchor in ER membrane (GO:0016254)2.76094091
45male meiosis I (GO:0007141)2.75466327
46cytidine metabolic process (GO:0046087)2.72987114
47cytidine catabolic process (GO:0006216)2.72987114
48cytidine deamination (GO:0009972)2.72987114
49polyol catabolic process (GO:0046174)2.72686668
50regulation of action potential (GO:0098900)2.72237285
51photoreceptor cell development (GO:0042461)2.69720234
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69318260
53organic cation transport (GO:0015695)2.69149499
54cell wall macromolecule metabolic process (GO:0044036)2.66885739
55mitotic cell cycle arrest (GO:0071850)2.65709204
56rRNA catabolic process (GO:0016075)2.64731406
57ubiquinone biosynthetic process (GO:0006744)2.61526604
58regulation of cilium movement (GO:0003352)2.59933165
59phosphorylated carbohydrate dephosphorylation (GO:0046838)2.56816159
60inositol phosphate dephosphorylation (GO:0046855)2.56816159
61mannosylation (GO:0097502)2.56736187
62synaptic transmission, cholinergic (GO:0007271)2.55444334
63amine catabolic process (GO:0009310)2.54300657
64cellular biogenic amine catabolic process (GO:0042402)2.54300657
65protein polyglutamylation (GO:0018095)2.53869437
66cornea development in camera-type eye (GO:0061303)2.53116431
67protein K11-linked deubiquitination (GO:0035871)2.51833491
68multicellular organism reproduction (GO:0032504)2.50608948
69auditory receptor cell stereocilium organization (GO:0060088)2.50385338
70kynurenine metabolic process (GO:0070189)2.49598896
71neuronal action potential (GO:0019228)2.48504413
72positive regulation of prostaglandin secretion (GO:0032308)2.48419619
73recombinational repair (GO:0000725)2.46377975
74double-strand break repair via homologous recombination (GO:0000724)2.44707428
75positive regulation of triglyceride biosynthetic process (GO:0010867)2.44313775
76phosphatidylinositol acyl-chain remodeling (GO:0036149)2.43674308
77regulation of nuclear cell cycle DNA replication (GO:0033262)2.43430206
78transepithelial transport (GO:0070633)2.42869122
79DNA double-strand break processing (GO:0000729)2.42348367
80eye photoreceptor cell development (GO:0042462)2.42341108
81negative regulation of macrophage differentiation (GO:0045650)2.41994775
82ubiquinone metabolic process (GO:0006743)2.40951609
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40869801
84estrogen metabolic process (GO:0008210)2.40187098
85protein complex biogenesis (GO:0070271)2.39463866
86reciprocal meiotic recombination (GO:0007131)2.39414017
87reciprocal DNA recombination (GO:0035825)2.39414017
88sperm motility (GO:0030317)2.39024696
89protein K6-linked ubiquitination (GO:0085020)2.37876859
90seminiferous tubule development (GO:0072520)2.37481891
91cilium morphogenesis (GO:0060271)2.37388882
92protein localization to Golgi apparatus (GO:0034067)2.36217306
93hormone biosynthetic process (GO:0042446)2.34745185
94vitamin biosynthetic process (GO:0009110)2.34333878
95negative regulation of reactive oxygen species metabolic process (GO:2000378)2.34309115
96regulation of glucokinase activity (GO:0033131)2.33688270
97regulation of hexokinase activity (GO:1903299)2.33688270
98establishment of protein localization to Golgi (GO:0072600)2.32980378
99meiotic chromosome segregation (GO:0045132)2.32780627
100cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.32227320

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.74235048
2VDR_22108803_ChIP-Seq_LS180_Human3.23483995
3IGF1R_20145208_ChIP-Seq_DFB_Human3.04386044
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81517953
5GBX2_23144817_ChIP-Seq_PC3_Human2.75103889
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60444471
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.24685588
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14597837
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12894394
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08652168
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.08599312
12EWS_26573619_Chip-Seq_HEK293_Human1.98365924
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95868365
14ER_23166858_ChIP-Seq_MCF-7_Human1.93669496
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87896860
16NOTCH1_21737748_ChIP-Seq_TLL_Human1.85073007
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81253770
18TP53_22573176_ChIP-Seq_HFKS_Human1.77613242
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76783122
20P300_19829295_ChIP-Seq_ESCs_Human1.76234374
21FUS_26573619_Chip-Seq_HEK293_Human1.75101916
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.74795801
23TAF15_26573619_Chip-Seq_HEK293_Human1.72933196
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70742561
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67520865
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.64098067
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59795888
28BCAT_22108803_ChIP-Seq_LS180_Human1.59504194
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50118888
30CBP_20019798_ChIP-Seq_JUKART_Human1.44756676
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44756676
32NANOG_19829295_ChIP-Seq_ESCs_Human1.42558100
33SOX2_19829295_ChIP-Seq_ESCs_Human1.42558100
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.40835237
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37543288
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37543288
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35197711
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34809531
39GATA3_21878914_ChIP-Seq_MCF-7_Human1.34795958
40* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31620290
41NCOR_22424771_ChIP-Seq_293T_Human1.31162371
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29573105
43VDR_23849224_ChIP-Seq_CD4+_Human1.29166055
44STAT3_23295773_ChIP-Seq_U87_Human1.28755234
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28114561
46ERA_21632823_ChIP-Seq_H3396_Human1.27845894
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27411377
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27158504
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25902692
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.25414203
51NANOG_20526341_ChIP-Seq_ESCs_Human1.24482479
52AR_25329375_ChIP-Seq_VCAP_Human1.23668949
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.23465322
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22801771
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22180025
56AR_20517297_ChIP-Seq_VCAP_Human1.21062916
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.21050813
58* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21011024
59* FOXA1_25329375_ChIP-Seq_VCAP_Human1.21011024
60* GATA3_26560356_Chip-Seq_TH2_Human1.20874460
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20656628
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19653287
63TCF4_23295773_ChIP-Seq_U87_Human1.19433874
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.18805796
65MYC_19829295_ChIP-Seq_ESCs_Human1.18537322
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18454286
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17735349
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17365897
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17208793
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16955759
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.16892028
72EZH2_22144423_ChIP-Seq_EOC_Human1.16844968
73TCF4_22108803_ChIP-Seq_LS180_Human1.16584421
74SMAD4_21799915_ChIP-Seq_A2780_Human1.16211483
75OCT4_20526341_ChIP-Seq_ESCs_Human1.16067178
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15695128
77HOXB7_26014856_ChIP-Seq_BT474_Human1.15623046
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14954622
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.14115571
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10959632
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08503780
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07667705
83RUNX2_22187159_ChIP-Seq_PCA_Human1.07514224
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06753788
85TAF2_19829295_ChIP-Seq_ESCs_Human1.06071847
86REST_21632747_ChIP-Seq_MESCs_Mouse1.05584311
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04922095
88AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04655593
89MYC_18940864_ChIP-ChIP_HL60_Human1.02525651
90FOXH1_21741376_ChIP-Seq_EPCs_Human1.01936014
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.01836950
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.01175377
93CDX2_22108803_ChIP-Seq_LS180_Human0.99447528
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98702431
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98229164
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.98085815
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97877352
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96221222
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96021408
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95875727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.95635474
2MP0001986_abnormal_taste_sensitivity3.36284138
3MP0008877_abnormal_DNA_methylation2.80508457
4MP0005174_abnormal_tail_pigmentation2.64893385
5MP0001968_abnormal_touch/_nociception2.64666131
6MP0008875_abnormal_xenobiotic_pharmacok2.59983854
7MP0005551_abnormal_eye_electrophysiolog2.42361395
8MP0003787_abnormal_imprinting2.33865905
9MP0002837_dystrophic_cardiac_calcinosis2.08055394
10MP0002736_abnormal_nociception_after2.03297947
11MP0002102_abnormal_ear_morphology1.99205406
12MP0005646_abnormal_pituitary_gland1.97921119
13MP0005253_abnormal_eye_physiology1.84765853
14MP0010386_abnormal_urinary_bladder1.84017196
15MP0006072_abnormal_retinal_apoptosis1.82814983
16MP0003136_yellow_coat_color1.82720920
17MP0002638_abnormal_pupillary_reflex1.79776743
18MP0000372_irregular_coat_pigmentation1.79311140
19MP0003806_abnormal_nucleotide_metabolis1.75904957
20MP0003011_delayed_dark_adaptation1.75778320
21MP0002876_abnormal_thyroid_physiology1.64198634
22MP0005171_absent_coat_pigmentation1.62222481
23MP0005084_abnormal_gallbladder_morpholo1.55422069
24MP0008872_abnormal_physiological_respon1.54398276
25MP0008995_early_reproductive_senescence1.48234945
26MP0002909_abnormal_adrenal_gland1.47090683
27MP0005671_abnormal_response_to1.43070869
28MP0000015_abnormal_ear_pigmentation1.42176704
29MP0001501_abnormal_sleep_pattern1.41108220
30MP0005423_abnormal_somatic_nervous1.36562672
31MP0002138_abnormal_hepatobiliary_system1.34594565
32MP0005410_abnormal_fertilization1.34050455
33MP0005645_abnormal_hypothalamus_physiol1.32760639
34MP0001188_hyperpigmentation1.32162420
35MP0005167_abnormal_blood-brain_barrier1.31499848
36MP0004147_increased_porphyrin_level1.26813280
37MP0009745_abnormal_behavioral_response1.25881890
38MP0006276_abnormal_autonomic_nervous1.24431794
39MP0005389_reproductive_system_phenotype1.23607949
40MP0004142_abnormal_muscle_tone1.23155085
41MP0002277_abnormal_respiratory_mucosa1.23014880
42MP0005075_abnormal_melanosome_morpholog1.22393904
43MP0006292_abnormal_olfactory_placode1.22301554
44MP0002272_abnormal_nervous_system1.20543118
45MP0003283_abnormal_digestive_organ1.19125542
46MP0001984_abnormal_olfaction1.19079891
47MP0005332_abnormal_amino_acid1.19060502
48MP0004043_abnormal_pH_regulation1.18683897
49MP0009046_muscle_twitch1.18481847
50MP0000538_abnormal_urinary_bladder1.16403429
51MP0000569_abnormal_digit_pigmentation1.14985922
52MP0002160_abnormal_reproductive_system1.14854475
53MP0001919_abnormal_reproductive_system1.09073839
54MP0003724_increased_susceptibility_to1.09028381
55MP0002735_abnormal_chemical_nociception1.07738881
56MP0001764_abnormal_homeostasis1.07093929
57MP0000013_abnormal_adipose_tissue1.06961456
58MP0001756_abnormal_urination1.06829251
59MP0003786_premature_aging1.06326904
60MP0001970_abnormal_pain_threshold1.05812337
61MP0001486_abnormal_startle_reflex1.05338427
62MP0001324_abnormal_eye_pigmentation1.03192919
63MP0009785_altered_susceptibility_to1.03064856
64MP0004133_heterotaxia1.02578435
65MP0003646_muscle_fatigue1.01971417
66MP0001905_abnormal_dopamine_level1.01785212
67MP0001661_extended_life_span1.01486278
68MP0003121_genomic_imprinting1.00605331
69MP0003172_abnormal_lysosome_physiology0.99992131
70MP0002938_white_spotting0.99701698
71MP0010329_abnormal_lipoprotein_level0.98962803
72MP0005377_hearing/vestibular/ear_phenot0.98423094
73MP0003878_abnormal_ear_physiology0.98423094
74MP0001485_abnormal_pinna_reflex0.98273373
75MP0002693_abnormal_pancreas_physiology0.97215041
76MP0005365_abnormal_bile_salt0.97213383
77MP0004885_abnormal_endolymph0.95953992
78MP0000427_abnormal_hair_cycle0.95173253
79MP0000639_abnormal_adrenal_gland0.95169199
80MP0000631_abnormal_neuroendocrine_gland0.93061788
81MP0009764_decreased_sensitivity_to0.92754817
82MP0001929_abnormal_gametogenesis0.92710463
83MP0003698_abnormal_male_reproductive0.88334471
84MP0002733_abnormal_thermal_nociception0.84963488
85MP0002229_neurodegeneration0.83323923
86MP0005386_behavior/neurological_phenoty0.82523194
87MP0004924_abnormal_behavior0.82523194
88MP0002095_abnormal_skin_pigmentation0.82171038
89MP0009780_abnormal_chondrocyte_physiolo0.81691806
90MP0000230_abnormal_systemic_arterial0.81621008
91MP0002148_abnormal_hypersensitivity_rea0.80905248
92MP0002928_abnormal_bile_duct0.80589930
93MP0002210_abnormal_sex_determination0.79967731
94MP0002572_abnormal_emotion/affect_behav0.79653305
95MP0005636_abnormal_mineral_homeostasis0.79591908
96MP0001790_abnormal_immune_system0.78684680
97MP0005387_immune_system_phenotype0.78684680
98MP0002557_abnormal_social/conspecific_i0.77695473
99MP0001835_abnormal_antigen_presentation0.76381625
100MP0000516_abnormal_urinary_system0.76170940

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.09379898
2Pancreatic cysts (HP:0001737)4.03203115
3Attenuation of retinal blood vessels (HP:0007843)3.97028211
4Pancreatic fibrosis (HP:0100732)3.56717456
5Molar tooth sign on MRI (HP:0002419)3.52963431
6Abnormality of midbrain morphology (HP:0002418)3.52963431
7True hermaphroditism (HP:0010459)3.52504351
8Nephronophthisis (HP:0000090)3.33279790
9Polydipsia (HP:0001959)3.09025150
10Abnormal drinking behavior (HP:0030082)3.09025150
11Abnormality of the renal cortex (HP:0011035)2.94831341
12Abnormality of the renal medulla (HP:0100957)2.85770027
13Chronic hepatic failure (HP:0100626)2.83476754
14Abnormal rod and cone electroretinograms (HP:0008323)2.75144531
15Male pseudohermaphroditism (HP:0000037)2.74470702
16Medial flaring of the eyebrow (HP:0010747)2.70576706
17Type II lissencephaly (HP:0007260)2.64880536
18Tubular atrophy (HP:0000092)2.64173576
19Methylmalonic acidemia (HP:0002912)2.60859875
20Decreased electroretinogram (ERG) amplitude (HP:0000654)2.60580658
21Bony spicule pigmentary retinopathy (HP:0007737)2.58544060
22Abolished electroretinogram (ERG) (HP:0000550)2.58134942
23Ketosis (HP:0001946)2.56240986
24Cystic liver disease (HP:0006706)2.56125855
25Lipid accumulation in hepatocytes (HP:0006561)2.52275709
26Rib fusion (HP:0000902)2.48004550
27Decreased central vision (HP:0007663)2.47724985
28Polyuria (HP:0000103)2.45444669
29Stomatitis (HP:0010280)2.41080440
30Congenital hepatic fibrosis (HP:0002612)2.39376073
31Methylmalonic aciduria (HP:0012120)2.37418302
32Ketoacidosis (HP:0001993)2.36788179
33Mitochondrial inheritance (HP:0001427)2.34017777
34Decreased circulating renin level (HP:0003351)2.33077893
35Renal cortical cysts (HP:0000803)2.30482891
36Congenital sensorineural hearing impairment (HP:0008527)2.25382353
37Increased hepatocellular lipid droplets (HP:0006565)2.22273250
38Renal Fanconi syndrome (HP:0001994)2.21282090
39Increased CSF lactate (HP:0002490)2.18596348
40Abnormal biliary tract physiology (HP:0012439)2.17668105
41Bile duct proliferation (HP:0001408)2.17668105
42Pendular nystagmus (HP:0012043)2.15776603
43Abnormal albumin level (HP:0012116)2.15442282
44Hypoalbuminemia (HP:0003073)2.15442282
45Hypothermia (HP:0002045)2.13616420
46Thyroiditis (HP:0100646)2.10344859
473-Methylglutaconic aciduria (HP:0003535)2.06431389
48Progressive inability to walk (HP:0002505)2.02896782
49Hepatocellular necrosis (HP:0001404)2.02875679
50Gaze-evoked nystagmus (HP:0000640)1.99732496
51Absent speech (HP:0001344)1.99414773
52Mesangial abnormality (HP:0001966)1.97776616
53Abnormal urine output (HP:0012590)1.97691426
54Hyperventilation (HP:0002883)1.97046140
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94822779
56Optic disc pallor (HP:0000543)1.94153187
57Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92221504
58Chorioretinal atrophy (HP:0000533)1.91663471
59Acute necrotizing encephalopathy (HP:0006965)1.90875844
60Azoospermia (HP:0000027)1.90292213
61Inability to walk (HP:0002540)1.87649349
62Progressive macrocephaly (HP:0004481)1.87254981
63Abnormality of vitamin B metabolism (HP:0004340)1.87045116
64Congenital primary aphakia (HP:0007707)1.86491460
65Gait imbalance (HP:0002141)1.86421740
66Cerebellar dysplasia (HP:0007033)1.86147101
67Hemiparesis (HP:0001269)1.84738203
68Hepatic necrosis (HP:0002605)1.84316052
69Tachypnea (HP:0002789)1.84107564
70Exertional dyspnea (HP:0002875)1.82813285
71Aplasia/hypoplasia of the uterus (HP:0008684)1.82260828
72Increased corneal curvature (HP:0100692)1.80614241
73Keratoconus (HP:0000563)1.80614241
74Facial diplegia (HP:0001349)1.79722107
75Nephrogenic diabetes insipidus (HP:0009806)1.77751731
76Large for gestational age (HP:0001520)1.77312570
77Hypoproteinemia (HP:0003075)1.76387459
78Sclerocornea (HP:0000647)1.76318104
79Dynein arm defect of respiratory motile cilia (HP:0012255)1.75812086
80Absent/shortened dynein arms (HP:0200106)1.75812086
81Anencephaly (HP:0002323)1.75393000
82Retinitis pigmentosa (HP:0000510)1.75215671
83Lissencephaly (HP:0001339)1.74615702
84Aplasia/Hypoplasia involving the musculature (HP:0001460)1.73590466
85Retinal dysplasia (HP:0007973)1.73247433
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.72913541
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.71606543
88Abnormality of the pons (HP:0007361)1.71171092
89Abnormality of eosinophils (HP:0001879)1.70951593
90Abnormality of urine glucose concentration (HP:0011016)1.70194197
91Glycosuria (HP:0003076)1.70194197
92Gonadal dysgenesis (HP:0000133)1.69953778
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69222313
94Abnormal protein N-linked glycosylation (HP:0012347)1.69222313
95Abnormal protein glycosylation (HP:0012346)1.69222313
96Abnormal glycosylation (HP:0012345)1.69222313
97Hypoplasia of the pons (HP:0012110)1.69079090
98Recurrent cutaneous fungal infections (HP:0011370)1.69063595
99Chronic mucocutaneous candidiasis (HP:0002728)1.69063595
100Macular degeneration (HP:0000608)1.68625641

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.59873940
2MAP4K23.45735948
3TAOK33.08714716
4ADRBK23.02283668
5TXK2.97823955
6PINK12.76385076
7NUAK12.53416294
8ZAK2.46774514
9GRK12.27632619
10BMPR1B2.27480460
11BCKDK2.01536190
12ACVR1B2.01290732
13TLK11.98425694
14WNK41.95733161
15WNK31.90860784
16MAPK131.78935309
17OXSR11.59816504
18INSRR1.50230350
19MAPK151.46379675
20MAP4K11.33418852
21DAPK21.29392204
22TRIM281.22481573
23CAMKK21.21577870
24TIE11.20244734
25STK391.17307664
26ADRBK11.13622199
27IKBKB1.13121376
28PAK31.00810542
29TNK20.99578094
30STK38L0.97961486
31MST40.96050468
32MAP3K40.91971757
33PLK20.91061067
34PRKCE0.90500101
35EIF2AK30.89578651
36MUSK0.87969925
37MAP2K60.87878328
38FGFR20.83521640
39CCNB10.81878551
40CSNK1G20.81275218
41PRKCQ0.81170986
42CSNK1G10.80423150
43TEC0.79803684
44PHKG20.78991585
45PHKG10.78991585
46MAPKAPK50.78199483
47DYRK20.74892231
48CSNK1G30.74323678
49MAPKAPK30.72333977
50FES0.71533778
51MKNK20.70715908
52PRKCG0.70151868
53NTRK30.69890505
54ITK0.68596767
55MAP2K70.68510347
56SYK0.68038479
57PTK2B0.66299514
58KIT0.65095351
59TNIK0.61292972
60VRK10.61153526
61AKT30.57918335
62SIK20.57699339
63BLK0.56635545
64GRK60.56319362
65IRAK10.56203275
66PDK20.56082571
67CSNK1A1L0.54952322
68LYN0.53864904
69CASK0.52735432
70IKBKE0.52209629
71TGFBR10.51445600
72CSF1R0.48303706
73TGFBR20.46662035
74BRSK20.45782691
75PRKAA20.45604116
76MAP3K120.44982135
77PRKACA0.43843633
78RPS6KA50.43621010
79GRK70.43133438
80ERBB30.42736516
81STK110.42164477
82CHUK0.41358022
83MARK30.41143055
84GRK50.39432863
85ABL10.39307107
86CSNK1D0.39212643
87VRK20.37879243
88CSNK1A10.35192736
89PRKG10.32983030
90PRKCA0.32527197
91PLK40.32500995
92SGK20.32289153
93MAP2K40.31083037
94NLK0.31042261
95CAMK10.30216704
96LCK0.30201411
97STK30.30124433
98IGF1R0.29959692
99JAK30.29475395
100PRKCZ0.28467716

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.21751182
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.07352838
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.73805268
4Phototransduction_Homo sapiens_hsa047442.39285353
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25243403
6Linoleic acid metabolism_Homo sapiens_hsa005912.17957354
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09929452
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08838078
9Butanoate metabolism_Homo sapiens_hsa006502.07822593
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.05359070
11Nitrogen metabolism_Homo sapiens_hsa009102.00217722
12Protein export_Homo sapiens_hsa030601.97435531
13Selenocompound metabolism_Homo sapiens_hsa004501.83666162
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.83082418
15Ether lipid metabolism_Homo sapiens_hsa005651.80256560
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73755567
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73031467
18Homologous recombination_Homo sapiens_hsa034401.72593756
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70341413
20Oxidative phosphorylation_Homo sapiens_hsa001901.64057079
21Sulfur metabolism_Homo sapiens_hsa009201.61126969
22Tryptophan metabolism_Homo sapiens_hsa003801.58309775
23Fanconi anemia pathway_Homo sapiens_hsa034601.53309924
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.50517919
25Sulfur relay system_Homo sapiens_hsa041221.47192731
26Ovarian steroidogenesis_Homo sapiens_hsa049131.46468249
27Propanoate metabolism_Homo sapiens_hsa006401.41192336
28Caffeine metabolism_Homo sapiens_hsa002321.37787197
29Primary immunodeficiency_Homo sapiens_hsa053401.37609900
30Regulation of autophagy_Homo sapiens_hsa041401.35830901
31Basal transcription factors_Homo sapiens_hsa030221.34522312
32Chemical carcinogenesis_Homo sapiens_hsa052041.30010408
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.29278335
34Peroxisome_Homo sapiens_hsa041461.25780847
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24633811
36Collecting duct acid secretion_Homo sapiens_hsa049661.24052653
37Type I diabetes mellitus_Homo sapiens_hsa049401.21665131
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21277794
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.20316072
40Non-homologous end-joining_Homo sapiens_hsa034501.19943829
41Nicotine addiction_Homo sapiens_hsa050331.18345877
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11877215
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06526317
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06476782
45Parkinsons disease_Homo sapiens_hsa050121.05330616
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97837273
47Taste transduction_Homo sapiens_hsa047420.95893552
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91278635
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89901177
50RNA polymerase_Homo sapiens_hsa030200.89503934
51ABC transporters_Homo sapiens_hsa020100.88124028
52Graft-versus-host disease_Homo sapiens_hsa053320.87386495
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86753398
54Rheumatoid arthritis_Homo sapiens_hsa053230.86449856
55Circadian rhythm_Homo sapiens_hsa047100.86042653
56Olfactory transduction_Homo sapiens_hsa047400.85626367
57Arachidonic acid metabolism_Homo sapiens_hsa005900.85516720
58Allograft rejection_Homo sapiens_hsa053300.83704613
59beta-Alanine metabolism_Homo sapiens_hsa004100.83628423
60Steroid biosynthesis_Homo sapiens_hsa001000.82553548
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.81603416
62Retinol metabolism_Homo sapiens_hsa008300.80476597
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78122577
64Mineral absorption_Homo sapiens_hsa049780.77718157
65Autoimmune thyroid disease_Homo sapiens_hsa053200.77132058
66Asthma_Homo sapiens_hsa053100.76491983
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73176449
68RNA degradation_Homo sapiens_hsa030180.69880336
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68693079
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68515453
71Staphylococcus aureus infection_Homo sapiens_hsa051500.66732974
72Fatty acid degradation_Homo sapiens_hsa000710.66637778
73One carbon pool by folate_Homo sapiens_hsa006700.66432741
74Insulin secretion_Homo sapiens_hsa049110.65706895
75Vitamin digestion and absorption_Homo sapiens_hsa049770.65333438
76Sphingolipid metabolism_Homo sapiens_hsa006000.63324953
77Metabolic pathways_Homo sapiens_hsa011000.63293357
78Histidine metabolism_Homo sapiens_hsa003400.62834803
79Glycerolipid metabolism_Homo sapiens_hsa005610.62407070
80Proteasome_Homo sapiens_hsa030500.61692351
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60217155
82Lysosome_Homo sapiens_hsa041420.58258326
83Fat digestion and absorption_Homo sapiens_hsa049750.55503513
84Huntingtons disease_Homo sapiens_hsa050160.54193822
85Alzheimers disease_Homo sapiens_hsa050100.52309702
86Dorso-ventral axis formation_Homo sapiens_hsa043200.51855287
87Morphine addiction_Homo sapiens_hsa050320.49258106
88Purine metabolism_Homo sapiens_hsa002300.48101474
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47521757
90Serotonergic synapse_Homo sapiens_hsa047260.47445355
91Calcium signaling pathway_Homo sapiens_hsa040200.44239566
92Salivary secretion_Homo sapiens_hsa049700.42676436
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.41813668
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41047366
95Hematopoietic cell lineage_Homo sapiens_hsa046400.39805467
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35454832
97Circadian entrainment_Homo sapiens_hsa047130.35352012
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35170875
99Glutamatergic synapse_Homo sapiens_hsa047240.33701994
100Fatty acid metabolism_Homo sapiens_hsa012120.33516706

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