SIGLEC15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1platelet dense granule organization (GO:0060155)6.32339828
2ribosomal small subunit assembly (GO:0000028)6.26053733
3viral transcription (GO:0019083)6.20074528
4translational termination (GO:0006415)5.84930678
5DNA unwinding involved in DNA replication (GO:0006268)5.62817510
6regulation of respiratory burst (GO:0060263)5.39067914
7ribosomal small subunit biogenesis (GO:0042274)5.38134299
8indole-containing compound catabolic process (GO:0042436)5.05477530
9indolalkylamine catabolic process (GO:0046218)5.05477530
10tryptophan catabolic process (GO:0006569)5.05477530
11endosome to pigment granule transport (GO:0043485)5.03313878
12endosome to melanosome transport (GO:0035646)5.03313878
13translational elongation (GO:0006414)5.02961042
14negative regulation of epidermal cell differentiation (GO:0045605)4.98173613
15proline biosynthetic process (GO:0006561)4.89474525
16protein localization to kinetochore (GO:0034501)4.79783702
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.79331486
18negative regulation of transcription by competitive promoter binding (GO:0010944)4.78488236
19protein targeting to ER (GO:0045047)4.69416031
20positive regulation of B cell differentiation (GO:0045579)4.67223055
21cotranslational protein targeting to membrane (GO:0006613)4.66168532
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.54913891
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.50541847
24viral life cycle (GO:0019058)4.46126999
25cellular protein complex disassembly (GO:0043624)4.41596923
26kynurenine metabolic process (GO:0070189)4.35158025
27protein localization to endoplasmic reticulum (GO:0070972)4.33786294
28negative regulation of viral entry into host cell (GO:0046597)4.25428748
29DNA duplex unwinding (GO:0032508)4.19241946
30DNA geometric change (GO:0032392)4.18586835
31DNA strand elongation involved in DNA replication (GO:0006271)4.17100622
32mitochondrial RNA metabolic process (GO:0000959)4.11180001
33citrulline biosynthetic process (GO:0019240)4.07424015
34negative regulation of mast cell activation (GO:0033004)4.04909139
35DNA strand elongation (GO:0022616)4.03887513
36tryptophan metabolic process (GO:0006568)4.01110688
37protein complex disassembly (GO:0043241)4.00740273
38translational initiation (GO:0006413)3.96562775
39B cell receptor signaling pathway (GO:0050853)3.87902566
40cellular hyperosmotic response (GO:0071474)3.84021332
41pentose-phosphate shunt (GO:0006098)3.82273342
42maturation of SSU-rRNA (GO:0030490)3.80437482
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79802760
44secretory granule organization (GO:0033363)3.79158979
45telomere maintenance via semi-conservative replication (GO:0032201)3.77675815
46indolalkylamine metabolic process (GO:0006586)3.77352887
47ribosomal large subunit biogenesis (GO:0042273)3.69500114
48V(D)J recombination (GO:0033151)3.69267938
49translesion synthesis (GO:0019985)3.69167092
50negative regulation of epidermis development (GO:0045683)3.68631929
51negative regulation of interleukin-12 production (GO:0032695)3.68042814
52positive regulation of defense response to virus by host (GO:0002230)3.67716403
53DNA replication initiation (GO:0006270)3.65076427
54protein localization to chromosome, centromeric region (GO:0071459)3.64998210
55macromolecular complex disassembly (GO:0032984)3.60922423
56DNA deamination (GO:0045006)3.57486144
57positive regulation of heat generation (GO:0031652)3.56247638
58regulation of hydrogen peroxide metabolic process (GO:0010310)3.55753953
59regulation of viral entry into host cell (GO:0046596)3.47667079
60blood coagulation, intrinsic pathway (GO:0007597)3.47597143
61negative regulation of viral transcription (GO:0032897)3.47308626
62Peyers patch development (GO:0048541)3.42386524
63mucosal-associated lymphoid tissue development (GO:0048537)3.42386524
64cellular biogenic amine catabolic process (GO:0042402)3.42056633
65amine catabolic process (GO:0009310)3.42056633
66L-fucose catabolic process (GO:0042355)3.41680244
67fucose catabolic process (GO:0019317)3.41680244
68L-fucose metabolic process (GO:0042354)3.41680244
69positive regulation of gamma-delta T cell activation (GO:0046645)3.41509202
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39342885
71mitotic recombination (GO:0006312)3.35215288
72alternative mRNA splicing, via spliceosome (GO:0000380)3.34877712
73regulation of B cell differentiation (GO:0045577)3.29665434
74positive regulation of natural killer cell activation (GO:0032816)3.29180472
75mRNA catabolic process (GO:0006402)3.29048566
76regulation of heat generation (GO:0031650)3.23616514
77positive regulation of prostaglandin secretion (GO:0032308)3.19668473
78immunoglobulin mediated immune response (GO:0016064)3.17189672
79NADPH regeneration (GO:0006740)3.17051759
80mitotic metaphase plate congression (GO:0007080)3.16803509
81protein targeting to membrane (GO:0006612)3.16032959
82aromatic amino acid family catabolic process (GO:0009074)3.15938547
83RNA catabolic process (GO:0006401)3.12328872
84negative regulation of phagocytosis (GO:0050765)3.12264833
85intra-S DNA damage checkpoint (GO:0031573)3.11948899
86defense response to fungus (GO:0050832)3.11220441
87nuclear-transcribed mRNA catabolic process (GO:0000956)3.11010022
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10927567
89antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10927567
90heart trabecula formation (GO:0060347)3.09660886
91positive regulation of granulocyte differentiation (GO:0030854)3.09233794
92proline metabolic process (GO:0006560)3.08412759
93NAD biosynthetic process (GO:0009435)3.06128703
94negative regulation of calcium ion transport into cytosol (GO:0010523)3.03087836
95metaphase plate congression (GO:0051310)3.02730411
96anterograde synaptic vesicle transport (GO:0048490)3.02710613
97antigen processing and presentation of endogenous antigen (GO:0019883)3.00919739
98regulation of viral release from host cell (GO:1902186)3.00249485
99germ cell migration (GO:0008354)2.99868941
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98254588
101negative regulation of telomere maintenance (GO:0032205)2.97722210
102antibacterial humoral response (GO:0019731)2.95778707
103deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95592352
104regulation of exit from mitosis (GO:0007096)2.93730597
105definitive hemopoiesis (GO:0060216)2.93610404
106positive regulation of histone deacetylation (GO:0031065)2.91113403
107defense response to protozoan (GO:0042832)2.90846698
108telomere maintenance via recombination (GO:0000722)2.90376959
109UDP-N-acetylglucosamine metabolic process (GO:0006047)2.89851126
110cellular response to ATP (GO:0071318)2.89608329
111developmental pigmentation (GO:0048066)2.88886993
112DNA replication checkpoint (GO:0000076)2.88231231
113heparin biosynthetic process (GO:0030210)2.86642445
114heparin metabolic process (GO:0030202)2.86642445
115regulation of gamma-delta T cell differentiation (GO:0045586)2.86492112
116response to protozoan (GO:0001562)2.86406845
117interferon-gamma production (GO:0032609)2.85792440
1183-UTR-mediated mRNA stabilization (GO:0070935)2.83850780
119response to interferon-beta (GO:0035456)2.82997902
120antimicrobial humoral response (GO:0019730)2.82872895
121barbed-end actin filament capping (GO:0051016)2.81219796
122negative regulation of RNA splicing (GO:0033119)2.79291144
123positive regulation of DNA biosynthetic process (GO:2000573)2.77453887
124regulation of T cell receptor signaling pathway (GO:0050856)2.77150921
125intracellular pH reduction (GO:0051452)2.76305500
126regulation of B cell receptor signaling pathway (GO:0050855)2.75792575
127telomere maintenance via telomere lengthening (GO:0010833)2.75493252
128cell wall macromolecule catabolic process (GO:0016998)2.74248600
129negative regulation of nitric oxide biosynthetic process (GO:0045019)2.71775844
130phagosome maturation (GO:0090382)2.71361773
131arginine catabolic process (GO:0006527)2.71216223
132cellular response to exogenous dsRNA (GO:0071360)2.70106216
133negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.68724114
134positive regulation of triglyceride biosynthetic process (GO:0010867)2.67779896
135negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.67033365
136water-soluble vitamin biosynthetic process (GO:0042364)2.64827900
137response to type I interferon (GO:0034340)2.64205184
138regulation of defense response to virus by host (GO:0050691)2.63118463
139cellular ketone body metabolic process (GO:0046950)2.62996762
140cellular response to type I interferon (GO:0071357)2.61662042
141type I interferon signaling pathway (GO:0060337)2.61662042
142positive regulation of antigen processing and presentation (GO:0002579)2.61258344
143negative regulation of macrophage differentiation (GO:0045650)2.60891833
144indole-containing compound metabolic process (GO:0042430)2.60016301
145protein K11-linked deubiquitination (GO:0035871)2.59610272
146regulation of memory T cell differentiation (GO:0043380)2.59177601
147cAMP catabolic process (GO:0006198)2.57631208
148regulation of prostaglandin secretion (GO:0032306)2.53963237
149cellular response to interferon-beta (GO:0035458)2.53636680
150N-acetylneuraminate metabolic process (GO:0006054)2.53405882
151pyridine nucleotide biosynthetic process (GO:0019363)2.50893023
152nicotinamide nucleotide biosynthetic process (GO:0019359)2.50893023
153amino sugar catabolic process (GO:0046348)2.48518601
154regulation of interferon-alpha production (GO:0032647)2.47589476
155response to pheromone (GO:0019236)2.46112598
156behavioral response to nicotine (GO:0035095)2.43999595
157interferon-gamma-mediated signaling pathway (GO:0060333)2.43832988
158negative regulation of interleukin-1 beta production (GO:0032691)2.43151681
159regulation of cytokine secretion involved in immune response (GO:0002739)2.43131636
160glycerophospholipid catabolic process (GO:0046475)2.43074473
161regulation of MHC class II biosynthetic process (GO:0045346)2.42882306
162cell wall macromolecule metabolic process (GO:0044036)2.41056704
163lytic vacuole organization (GO:0080171)2.40990348
164lysosome organization (GO:0007040)2.40990348
165pH reduction (GO:0045851)2.40490904
166eosinophil chemotaxis (GO:0048245)2.40291014
167ketone body metabolic process (GO:1902224)2.36832745
168adaptation of signaling pathway (GO:0023058)2.36729121
169regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.36480152
170negative regulation of lipid storage (GO:0010888)2.36296797
171cellular response to ethanol (GO:0071361)2.36182529
172regulation of nuclear cell cycle DNA replication (GO:0033262)2.34575619
173regulation of chronic inflammatory response (GO:0002676)2.34503550
174regulation of antigen processing and presentation (GO:0002577)2.34246964
175vitamin biosynthetic process (GO:0009110)2.33488943
176sphingoid metabolic process (GO:0046519)2.33425907
177arginine metabolic process (GO:0006525)2.32969994
178negative regulation of granulocyte differentiation (GO:0030853)2.32930714
179positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.31799058
180regulation of fever generation (GO:0031620)2.29830213
181benzene-containing compound metabolic process (GO:0042537)2.29693496
182cyclic nucleotide catabolic process (GO:0009214)2.29071114
183regulation of interleukin-12 production (GO:0032655)2.27953433
184epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.26982221
185positive regulation of fatty acid transport (GO:2000193)2.25549452
186regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.24413669
187T-helper 1 type immune response (GO:0042088)2.23153930
188regulation of MHC class I biosynthetic process (GO:0045343)2.22964298
189negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.22607236
190cytokine biosynthetic process (GO:0042089)2.21921627
191regulation of mast cell activation (GO:0033003)2.21364341
192B cell mediated immunity (GO:0019724)2.21224980
193detection of light stimulus involved in visual perception (GO:0050908)2.20998019
194detection of light stimulus involved in sensory perception (GO:0050962)2.20998019

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.09355709
2ZNF274_21170338_ChIP-Seq_K562_Hela3.59110402
3MYC_22102868_ChIP-Seq_BL_Human3.55039654
4VDR_21846776_ChIP-Seq_THP-1_Human3.43467560
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22121989
6SCL_19346495_ChIP-Seq_HPC-7_Human3.04491999
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.95034218
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.87121866
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.76880794
10VDR_22108803_ChIP-Seq_LS180_Human2.73352110
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.71383181
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.69712131
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.56021360
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.54934180
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54025036
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46594010
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44681210
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.39809383
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.33125977
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.24603845
21VDR_24763502_ChIP-Seq_THP-1_Human2.20484011
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18700143
23GBX2_23144817_ChIP-Seq_PC3_Human2.18212024
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18141186
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15791888
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.13140913
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13136168
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01108823
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99990265
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.99834229
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96019405
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95334172
33TCF7_22412390_ChIP-Seq_EML_Mouse1.93961994
34EZH2_22144423_ChIP-Seq_EOC_Human1.92512462
35IGF1R_20145208_ChIP-Seq_DFB_Human1.90663642
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89454327
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83888540
38XRN2_22483619_ChIP-Seq_HELA_Human1.79025057
39UTX_26944678_Chip-Seq_JUKART_Human1.70190827
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.70111707
41AR_21909140_ChIP-Seq_LNCAP_Human1.69515134
42* MYB_26560356_Chip-Seq_TH2_Human1.69429758
43GATA1_22025678_ChIP-Seq_K562_Human1.68170127
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67036741
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65395377
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.63488246
47P300_19829295_ChIP-Seq_ESCs_Human1.61601242
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61091030
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.59857628
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58929376
51KDM2B_26808549_Chip-Seq_DND41_Human1.57762231
52MAF_26560356_Chip-Seq_TH1_Human1.57050015
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56994929
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.56160353
55GATA3_26560356_Chip-Seq_TH2_Human1.55206927
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55134540
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.55078827
58ER_23166858_ChIP-Seq_MCF-7_Human1.54513912
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53582371
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53262215
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.53191985
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53095558
63SPI1_23547873_ChIP-Seq_NB4_Human1.51869487
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.51457649
65VDR_24787735_ChIP-Seq_THP-1_Human1.51343273
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50713394
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48657046
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48050740
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48040377
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47941788
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47622878
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47257819
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46659150
74* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46393624
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45854407
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44333590
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44105381
78TAF15_26573619_Chip-Seq_HEK293_Human1.42224131
79MYB_26560356_Chip-Seq_TH1_Human1.41632801
80BCAT_22108803_ChIP-Seq_LS180_Human1.41136858
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41022984
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40923032
83TTF2_22483619_ChIP-Seq_HELA_Human1.40439103
84AR_25329375_ChIP-Seq_VCAP_Human1.39536257
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39461759
86CBP_20019798_ChIP-Seq_JUKART_Human1.39461759
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37877801
88NANOG_19829295_ChIP-Seq_ESCs_Human1.37268235
89SOX2_19829295_ChIP-Seq_ESCs_Human1.37268235
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36216791
91SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35997545
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33473344
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.32302691
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.32212692
95TP53_22573176_ChIP-Seq_HFKS_Human1.31542674
96IRF8_27001747_Chip-Seq_BMDM_Mouse1.30968999
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29927190
98FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28647603
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.28647603
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28332016
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27480435
102GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26845736
103* STAT3_23295773_ChIP-Seq_U87_Human1.26298486
104GATA3_21878914_ChIP-Seq_MCF-7_Human1.25023610
105MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23641091
106* LXR_22292898_ChIP-Seq_THP-1_Human1.23387614
107RUNX_20019798_ChIP-Seq_JUKART_Human1.23088689
108CDX2_22108803_ChIP-Seq_LS180_Human1.23042724
109RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21466754
110NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21318087
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21186567
112* SMAD4_21741376_ChIP-Seq_EPCs_Human1.19262199
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18600557
114EWS_26573619_Chip-Seq_HEK293_Human1.17547579
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17343879
116FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16834318
117AR_20517297_ChIP-Seq_VCAP_Human1.14664298
118FOXP3_21729870_ChIP-Seq_TREG_Human1.14024029
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.13546383
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13520151
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.13092096
122BP1_19119308_ChIP-ChIP_Hs578T_Human1.11802527
123SMRT_27268052_Chip-Seq_Bcells_Human1.11576473
124TCF4_23295773_ChIP-Seq_U87_Human1.11203654
125* TCF4_22108803_ChIP-Seq_LS180_Human1.10682394
126SMAD4_21799915_ChIP-Seq_A2780_Human1.10506749
127FLI1_21867929_ChIP-Seq_TH2_Mouse1.09929541
128CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09325398
129NCOR1_26117541_ChIP-Seq_K562_Human1.09322205
130JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09297670
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09260245
132SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08786107
133STAT1_20625510_ChIP-Seq_HELA_Human1.08661809
134MAF_26560356_Chip-Seq_TH2_Human1.08583543
135SPI1_23127762_ChIP-Seq_K562_Human1.08436138
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07981052
137* KDM2B_26808549_Chip-Seq_JURKAT_Human1.07769380
138CRX_20693478_ChIP-Seq_RETINA_Mouse1.07329360
139TAF2_19829295_ChIP-Seq_ESCs_Human1.06936180
140* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05714266
141ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04837885
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03855290
143IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03702651
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03279565
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03137911
146GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02899373
147BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01992168
148MYC_19829295_ChIP-Seq_ESCs_Human1.00362226
149FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00318083
150FUS_26573619_Chip-Seq_HEK293_Human0.99630556
151STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99543951
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99065081
153HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99010514
154MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98394614
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98178294
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98178294
157RACK7_27058665_Chip-Seq_MCF-7_Human0.98141043
158CIITA_25753668_ChIP-Seq_RAJI_Human0.97958138
159POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97728085
160IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96932634
161* CJUN_26792858_Chip-Seq_BT549_Human0.96823802
162RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96309288
163MYC_18940864_ChIP-ChIP_HL60_Human0.95272171
164PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95143456
165DCP1A_22483619_ChIP-Seq_HELA_Human0.94575291
166CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94317510
167GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93421337
168MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93347865
169EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93262380
170ELF1_20517297_ChIP-Seq_JURKAT_Human0.93002906
171GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92934114
172RUNX2_22187159_ChIP-Seq_PCA_Human0.91930853
173AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91527964
174TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90985169
175ETS1_20019798_ChIP-Seq_JURKAT_Human0.88595520
176MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88189075
177HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87712749
178NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87445305
179LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87127066
180BCL6_27268052_Chip-Seq_Bcells_Human0.86621679
181HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86615334
182CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86246613
183DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85661984
184KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84845632
185VDR_23849224_ChIP-Seq_CD4+_Human0.84149570
186CTCF_26484167_Chip-Seq_Bcells_Mouse0.82511374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell7.21132904
2MP0002102_abnormal_ear_morphology4.28754543
3MP0005174_abnormal_tail_pigmentation4.00835522
4MP0003195_calcinosis3.42226010
5MP0003172_abnormal_lysosome_physiology2.99985218
6MP0003646_muscle_fatigue2.92725953
7MP0000015_abnormal_ear_pigmentation2.84707792
8MP0005167_abnormal_blood-brain_barrier2.83601688
9MP0002396_abnormal_hematopoietic_system2.80597704
10MP0003724_increased_susceptibility_to2.60772358
11MP0009764_decreased_sensitivity_to2.47140255
12MP0009278_abnormal_bone_marrow2.43223506
13MP0002837_dystrophic_cardiac_calcinosis2.34047891
14MP0004808_abnormal_hematopoietic_stem2.28906858
15MP0010094_abnormal_chromosome_stability2.23907856
16MP0000685_abnormal_immune_system2.22608320
17MP0000465_gastrointestinal_hemorrhage2.19253268
18MP0005397_hematopoietic_system_phenotyp2.17947512
19MP0001545_abnormal_hematopoietic_system2.17947512
20MP0003300_gastrointestinal_ulcer2.16506527
21MP0000462_abnormal_digestive_system2.08813552
22MP0002138_abnormal_hepatobiliary_system2.08637983
23MP0001501_abnormal_sleep_pattern2.07689070
24MP0010352_gastrointestinal_tract_polyps2.02051287
25MP0002139_abnormal_hepatobiliary_system1.97393458
26MP0005075_abnormal_melanosome_morpholog1.96714299
27MP0005464_abnormal_platelet_physiology1.95775563
28MP0003763_abnormal_thymus_physiology1.91793768
29MP0002166_altered_tumor_susceptibility1.91426009
30MP0004381_abnormal_hair_follicle1.86925186
31MP0003656_abnormal_erythrocyte_physiolo1.84868556
32MP0001348_abnormal_lacrimal_gland1.79557971
33MP0003566_abnormal_cell_adhesion1.78686525
34MP0004043_abnormal_pH_regulation1.77414470
35MP0005058_abnormal_lysosome_morphology1.75704821
36MP0002060_abnormal_skin_morphology1.73615454
37MP0002006_tumorigenesis1.68972430
38MP0001800_abnormal_humoral_immune1.68396395
39MP0002398_abnormal_bone_marrow1.67859797
40MP0001835_abnormal_antigen_presentation1.67106855
41MP0009379_abnormal_foot_pigmentation1.66262227
42MP0008875_abnormal_xenobiotic_pharmacok1.65510617
43MP0003191_abnormal_cellular_cholesterol1.63302303
44MP0004947_skin_inflammation1.61786091
45MP0010386_abnormal_urinary_bladder1.60240435
46MP0003283_abnormal_digestive_organ1.60214821
47MP0003303_peritoneal_inflammation1.59755879
48MP0000703_abnormal_thymus_morphology1.59662755
49MP0002254_reproductive_system_inflammat1.58969214
50MP0002722_abnormal_immune_system1.55787246
51MP0005645_abnormal_hypothalamus_physiol1.55781849
52MP0002452_abnormal_antigen_presenting1.54866360
53MP0005000_abnormal_immune_tolerance1.51018151
54MP0001873_stomach_inflammation1.49710188
55MP0009046_muscle_twitch1.49409166
56MP0002095_abnormal_skin_pigmentation1.49404871
57MP0003806_abnormal_nucleotide_metabolis1.46508237
58MP0002405_respiratory_system_inflammati1.45762217
59MP0003950_abnormal_plasma_membrane1.44639387
60MP0005387_immune_system_phenotype1.44545368
61MP0001790_abnormal_immune_system1.44545368
62MP0000689_abnormal_spleen_morphology1.42694047
63MP0005310_abnormal_salivary_gland1.40748570
64MP0001853_heart_inflammation1.40179242
65MP0001243_abnormal_dermal_layer1.40003980
66MP0008057_abnormal_DNA_replication1.38756399
67MP0003075_altered_response_to1.38577039
68MP0000490_abnormal_crypts_of1.37402703
69MP0000604_amyloidosis1.35839646
70MP0002420_abnormal_adaptive_immunity1.35708809
71MP0000716_abnormal_immune_system1.34163143
72MP0006054_spinal_hemorrhage1.33882101
73MP0004510_myositis1.33785373
74MP0001819_abnormal_immune_cell1.32810980
75MP0002723_abnormal_immune_serum1.30741159
76MP0001764_abnormal_homeostasis1.30557819
77MP0006082_CNS_inflammation1.24733115
78MP0003436_decreased_susceptibility_to1.24199213
79MP0002933_joint_inflammation1.23939181
80MP0002429_abnormal_blood_cell1.23470570
81MP0001986_abnormal_taste_sensitivity1.22329791
82MP0000343_altered_response_to1.21041697
83MP0010155_abnormal_intestine_physiology1.20328600
84MP0008469_abnormal_protein_level1.20276056
85MP0008995_early_reproductive_senescence1.17576572
86MP0002234_abnormal_pharynx_morphology1.17124551
87MP0003045_fibrosis1.16750830
88MP0005551_abnormal_eye_electrophysiolog1.15959062
89MP0000377_abnormal_hair_follicle1.13842516
90MP0005671_abnormal_response_to1.13810675
91MP0005025_abnormal_response_to1.12289726
92MP0001919_abnormal_reproductive_system1.11758100
93MP0009333_abnormal_splenocyte_physiolog1.10955701
94MP0008877_abnormal_DNA_methylation1.10721518
95MP0005381_digestive/alimentary_phenotyp1.10586318
96MP0003693_abnormal_embryo_hatching1.08019132
97MP0003705_abnormal_hypodermis_morpholog1.06266086
98MP0003077_abnormal_cell_cycle1.06062847
99MP0009780_abnormal_chondrocyte_physiolo1.05286163
100MP0008007_abnormal_cellular_replicative1.04872916
101MP0002876_abnormal_thyroid_physiology1.03787560
102MP0009785_altered_susceptibility_to1.03650529
103MP0008770_decreased_survivor_rate1.02105630
104MP0010307_abnormal_tumor_latency1.01258328
105MP0003279_aneurysm1.01225827
106MP0001663_abnormal_digestive_system1.00820881
107MP0002693_abnormal_pancreas_physiology0.99374792
108MP0005360_urolithiasis0.97463311
109MP0005253_abnormal_eye_physiology0.97362962
110MP0005410_abnormal_fertilization0.97156496
111MP0005647_abnormal_sex_gland0.96799422
112MP0000858_altered_metastatic_potential0.95565694
113MP0000750_abnormal_muscle_regeneration0.95553218
114MP0005367_renal/urinary_system_phenotyp0.94188921
115MP0000516_abnormal_urinary_system0.94188921
116MP0002419_abnormal_innate_immunity0.93546815
117MP0006072_abnormal_retinal_apoptosis0.93218343
118MP0004883_abnormal_blood_vessel0.91576409
119MP0003111_abnormal_nucleus_morphology0.91434185
120MP0002019_abnormal_tumor_incidence0.90792833
121MP0005646_abnormal_pituitary_gland0.90692355
122MP0008438_abnormal_cutaneous_collagen0.88837195
123MP0008872_abnormal_physiological_respon0.86414162
124MP0002269_muscular_atrophy0.85973075
125MP0002332_abnormal_exercise_endurance0.85050543
126MP0010234_abnormal_vibrissa_follicle0.83982530
127MP0003091_abnormal_cell_migration0.83927771
128MP0002148_abnormal_hypersensitivity_rea0.83649173
129MP0002970_abnormal_white_adipose0.82795129
130MP0002277_abnormal_respiratory_mucosa0.81701274
131MP0003718_maternal_effect0.81176899
132MP0005365_abnormal_bile_salt0.80459113
133MP0000230_abnormal_systemic_arterial0.79777493
134MP0000647_abnormal_sebaceous_gland0.79612505
135MP0003633_abnormal_nervous_system0.79091392
136MP0003938_abnormal_ear_development0.79005729
137MP0000569_abnormal_digit_pigmentation0.77376776
138MP0000371_diluted_coat_color0.77253456
139MP0000313_abnormal_cell_death0.76194044
140MP0005595_abnormal_vascular_smooth0.76105257
141MP0009745_abnormal_behavioral_response0.76092673
142MP0002998_abnormal_bone_remodeling0.75506686
143MP0003786_premature_aging0.75253296
144MP0000477_abnormal_intestine_morphology0.74961964
145MP0001968_abnormal_touch/_nociception0.74451436
146MP0001970_abnormal_pain_threshold0.73161285
147MP0001533_abnormal_skeleton_physiology0.72954131
148MP0005084_abnormal_gallbladder_morpholo0.72916291
149MP0001845_abnormal_inflammatory_respons0.72514811
150MP0002736_abnormal_nociception_after0.72459122
151MP0004272_abnormal_basement_membrane0.72334430
152MP0000470_abnormal_stomach_morphology0.71600723
153MP0000733_abnormal_muscle_development0.71409371
154MP0001849_ear_inflammation0.70942902
155MP0005166_decreased_susceptibility_to0.70658997
156MP0000383_abnormal_hair_follicle0.69938691
157MP0001542_abnormal_bone_strength0.69738164

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.59152622
2Increased mean platelet volume (HP:0011877)5.25389513
3Abnormal platelet volume (HP:0011876)5.24031004
4Albinism (HP:0001022)4.82111397
5Autoimmune thrombocytopenia (HP:0001973)4.76905985
6Abnormality of liposaccharide metabolism (HP:0010968)4.66125286
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.66125286
8Abnormality of glycolipid metabolism (HP:0010969)4.66125286
9Prolonged bleeding time (HP:0003010)4.50411183
10Purpura (HP:0000979)4.01650183
11Cellulitis (HP:0100658)4.01297308
12B lymphocytopenia (HP:0010976)3.97082165
13Abnormality of B cell number (HP:0010975)3.97082165
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.87566048
15Chronic otitis media (HP:0000389)3.84173443
16Increased cerebral lipofuscin (HP:0011813)3.83931748
17Stomatitis (HP:0010280)3.80159461
18Panhypogammaglobulinemia (HP:0003139)3.74021601
19Vacuolated lymphocytes (HP:0001922)3.68939580
20Menorrhagia (HP:0000132)3.63734111
21Recurrent viral infections (HP:0004429)3.58497635
22Hematochezia (HP:0002573)3.46543004
23Hypoproteinemia (HP:0003075)3.46040956
24Papilledema (HP:0001085)3.44136331
25Muscle fiber atrophy (HP:0100295)3.43630344
26Dysostosis multiplex (HP:0000943)3.41087735
27Abnormality of cells of the erythroid lineage (HP:0012130)3.40816940
28Thyroiditis (HP:0100646)3.37278985
29Pancreatic cysts (HP:0001737)3.32355119
30Abnormal number of erythroid precursors (HP:0012131)3.19927998
31Pallor (HP:0000980)3.16061764
32Abnormality of polysaccharide metabolism (HP:0011012)3.13053337
33Abnormality of glycosaminoglycan metabolism (HP:0004371)3.13053337
34Abnormality of mucopolysaccharide metabolism (HP:0011020)3.13053337
35T lymphocytopenia (HP:0005403)3.12554667
36Petechiae (HP:0000967)3.12252556
37Abnormal platelet function (HP:0011869)3.06461349
38Impaired platelet aggregation (HP:0003540)3.06461349
39Congenital stationary night blindness (HP:0007642)3.03534165
40Increased density of long bones (HP:0006392)2.97811315
41Retrobulbar optic neuritis (HP:0100654)2.92086900
42Optic neuritis (HP:0100653)2.92086900
43Hyperventilation (HP:0002883)2.87980798
44Abnormality of T cell number (HP:0011839)2.84235720
45Clumsiness (HP:0002312)2.81962544
46Ankle contracture (HP:0006466)2.80927144
47Polydipsia (HP:0001959)2.79868500
48Abnormal drinking behavior (HP:0030082)2.79868500
49Urinary glycosaminoglycan excretion (HP:0003541)2.79033786
50Mucopolysacchariduria (HP:0008155)2.79033786
51Progressive neurologic deterioration (HP:0002344)2.76469956
52Colon cancer (HP:0003003)2.74388393
53Severe short stature (HP:0003510)2.73613935
54Type 2 muscle fiber atrophy (HP:0003554)2.68180641
55Hypoplasia of the thymus (HP:0000778)2.66985893
56Abolished electroretinogram (ERG) (HP:0000550)2.65561240
57Abnormality of the renal cortex (HP:0011035)2.64995244
58Pancreatic fibrosis (HP:0100732)2.64692366
59Stomach cancer (HP:0012126)2.64277223
60Abnormality of midbrain morphology (HP:0002418)2.61588613
61Molar tooth sign on MRI (HP:0002419)2.61588613
62Orchitis (HP:0100796)2.61246166
63Severe visual impairment (HP:0001141)2.60404332
64Methylmalonic aciduria (HP:0012120)2.57928387
65Agammaglobulinemia (HP:0004432)2.56486054
66Premature rupture of membranes (HP:0001788)2.56231504
67Myositis (HP:0100614)2.54108538
68Recurrent fungal infections (HP:0002841)2.52392248
69Prostate neoplasm (HP:0100787)2.49119120
70Elevated erythrocyte sedimentation rate (HP:0003565)2.48679422
71Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.46437828
72Protrusio acetabuli (HP:0003179)2.45856941
73Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44568538
74Poor head control (HP:0002421)2.44036525
75Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42855331
76Ulnar bowing (HP:0003031)2.42423345
77Osteomyelitis (HP:0002754)2.41889692
78Attenuation of retinal blood vessels (HP:0007843)2.40326056
79Abnormality of reticulocytes (HP:0004312)2.37058377
80Thrombocytosis (HP:0001894)2.34955461
81Ocular albinism (HP:0001107)2.30737985
82IgM deficiency (HP:0002850)2.30590851
83Wormian bones (HP:0002645)2.30581397
84Bowing of the arm (HP:0006488)2.28893805
85Bowed forearm bones (HP:0003956)2.28893805
86Macrocytic anemia (HP:0001972)2.28549213
87Verrucae (HP:0200043)2.27642636
88Papilloma (HP:0012740)2.27642636
89Disproportionate short-trunk short stature (HP:0003521)2.24873052
90Progressive inability to walk (HP:0002505)2.24670059
91Congenital sensorineural hearing impairment (HP:0008527)2.23337903
92Severe combined immunodeficiency (HP:0004430)2.21845200
93Epistaxis (HP:0000421)2.21317680
94Abnormality of macrophages (HP:0004311)2.20592613
95True hermaphroditism (HP:0010459)2.20223619
96Aplasia/Hypoplasia of the spleen (HP:0010451)2.19109597
97Combined immunodeficiency (HP:0005387)2.17782020
98Atrophic scars (HP:0001075)2.17299325
99Asplenia (HP:0001746)2.16038955
100Nephronophthisis (HP:0000090)2.15752062
101Metaphyseal irregularity (HP:0003025)2.15020766
102Tubular atrophy (HP:0000092)2.14635383
103Hemoptysis (HP:0002105)2.14128115
10411 pairs of ribs (HP:0000878)2.13962696
105Poikiloderma (HP:0001029)2.13811431
106Loss of speech (HP:0002371)2.13643758
107Mutism (HP:0002300)2.12970551
108Fragile skin (HP:0001030)2.11831703
109Pulmonary infiltrates (HP:0002113)2.08621305
110Interstitial pulmonary disease (HP:0006530)2.08106081
111Polyuria (HP:0000103)2.08093737
112Abnormality of transition element cation homeostasis (HP:0011030)2.07295630
113Abnormality of the intervertebral disk (HP:0005108)2.03920396
114Generalized aminoaciduria (HP:0002909)2.03304559
115Generalized hypopigmentation (HP:0007513)2.02021494
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01912841
117Abnormality of alanine metabolism (HP:0010916)2.01912841
118Hyperalaninemia (HP:0003348)2.01912841
119Recurrent bacterial skin infections (HP:0005406)2.01525450
120Pili torti (HP:0003777)2.01217962
121Bile duct proliferation (HP:0001408)2.00657007
122Abnormal biliary tract physiology (HP:0012439)2.00657007
123Parakeratosis (HP:0001036)2.00373992
124Ketoacidosis (HP:0001993)2.00091907
125Abnormal rod and cone electroretinograms (HP:0008323)1.99986286
126Abnormality of the renal medulla (HP:0100957)1.99234344
127Gaze-evoked nystagmus (HP:0000640)1.99005326
128Volvulus (HP:0002580)1.98832571
129Methylmalonic acidemia (HP:0002912)1.98742206
130Tongue fasciculations (HP:0001308)1.98479500
131Rectal prolapse (HP:0002035)1.97544464
132Type II lissencephaly (HP:0007260)1.97345337
133Basal cell carcinoma (HP:0002671)1.96076319
134Chronic hepatic failure (HP:0100626)1.96034163
135Keratoconjunctivitis (HP:0001096)1.95642491
136Reduced antithrombin III activity (HP:0001976)1.95035703
137Abnormality of the prostate (HP:0008775)1.94581442
138Congenital hepatic fibrosis (HP:0002612)1.93604693
139Abnormal delayed hypersensitivity skin test (HP:0002963)1.93167331
140Gingival bleeding (HP:0000225)1.92685315
141Slender long bone (HP:0003100)1.92071172
142Radial bowing (HP:0002986)1.92017318
143Ileus (HP:0002595)1.92005593
144Stridor (HP:0010307)1.91061661
145Adactyly (HP:0009776)1.90733002
146Aplasia/Hypoplasia of the thymus (HP:0010515)1.90665594
147Chronic mucocutaneous candidiasis (HP:0002728)1.90646514
148Recurrent cutaneous fungal infections (HP:0011370)1.90646514
149Sepsis (HP:0100806)1.90638460
150Macular degeneration (HP:0000608)1.90540273
151Abnormality of T cells (HP:0002843)1.90140123
152Mitral regurgitation (HP:0001653)1.90111492
153Osteolytic defects of the hand bones (HP:0009699)1.90004704
154Osteolytic defects of the phalanges of the hand (HP:0009771)1.90004704
155Wide cranial sutures (HP:0010537)1.89408946
156Bruising susceptibility (HP:0000978)1.88708787
157Absent speech (HP:0001344)1.88061262
158Mediastinal lymphadenopathy (HP:0100721)1.87686532
159Meningitis (HP:0001287)1.87678495
160Ketosis (HP:0001946)1.86622082
161Hypophosphatemic rickets (HP:0004912)1.86385137
162Selective tooth agenesis (HP:0001592)1.86385073
163Gastrointestinal inflammation (HP:0004386)1.86339919
164Increased corneal curvature (HP:0100692)1.85943536
165Keratoconus (HP:0000563)1.85943536
166Ankyloglossia (HP:0010296)1.85611698
167Lymphoma (HP:0002665)1.85508445
168Abnormality of the periventricular white matter (HP:0002518)1.84223514
169Tubulointerstitial fibrosis (HP:0005576)1.83837226
170Amniotic constriction ring (HP:0009775)1.82407933
171Abnormality of placental membranes (HP:0011409)1.82407933
172Hyperacusis (HP:0010780)1.82400905
173Eosinophilia (HP:0001880)1.82243442
174IgG deficiency (HP:0004315)1.82098794
175Iris hypopigmentation (HP:0007730)1.81980348
176Renal cortical cysts (HP:0000803)1.80809807
177Hepatocellular necrosis (HP:0001404)1.80350210
178Decreased central vision (HP:0007663)1.80286346
179Inflammation of the large intestine (HP:0002037)1.80185084
180Recurrent abscess formation (HP:0002722)1.80074669
181Abnormality of the odontoid process (HP:0003310)1.79742258
182Colitis (HP:0002583)1.78697398
183Muscle fibrillation (HP:0010546)1.77871755
184High pitched voice (HP:0001620)1.77024289
185Inability to walk (HP:0002540)1.76539591
186Disinhibition (HP:0000734)1.76517777
187Cutaneous melanoma (HP:0012056)1.75333519
188Calcaneovalgus deformity (HP:0001848)1.74951377
189Increased CSF protein (HP:0002922)1.72172270
190Abnormality of the vertebral endplates (HP:0005106)1.70643376
191Mesangial abnormality (HP:0001966)1.70587554
192Cystic liver disease (HP:0006706)1.69416882
193Pustule (HP:0200039)1.67657486
194Abnormal urine output (HP:0012590)1.67158572
195Genetic anticipation (HP:0003743)1.67034288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK17.35345336
2FRK5.57155608
3TLK14.92013453
4ADRBK23.60984245
5MAP3K103.51869642
6ACVR1B3.19743848
7EEF2K2.94369362
8NME22.81166083
9PINK12.61995854
10DAPK22.59109298
11PKN22.58996662
12TXK2.43739143
13TEC2.32041504
14WNK42.30569676
15GRK12.28716290
16PIM22.24501992
17WEE12.18307787
18MAP3K92.17584915
19ZAK2.13431347
20GRK72.07210298
21FLT32.05770750
22BMPR1B2.02849235
23MAP4K21.96935835
24MAP4K11.90517305
25IKBKB1.82347060
26IRAK31.80496884
27BTK1.75419993
28MAPK131.71712769
29MAP3K31.67496363
30STK391.67417755
31KIT1.60285536
32STK241.59795135
33ERN11.54929656
34RPS6KA41.54225440
35INSRR1.51988313
36CDK121.43876598
37LRRK21.43027800
38TRIB31.36738451
39CSF1R1.34246275
40WNK31.34244400
41IKBKE1.31851540
42NUAK11.30784838
43MAP3K131.28740771
44STK161.28604683
45SYK1.28463666
46NEK21.27772819
47GRK61.23133121
48STK101.23059641
49TTN1.19393755
50FES1.18975958
51CDK191.18876663
52BUB11.16811260
53MAP3K141.16807600
54RAF11.14670885
55CCNB11.13082275
56RPS6KB21.12708924
57PTK2B1.03165739
58EPHA21.02667345
59PTK61.00009290
60ARAF0.97453619
61CAMKK20.96579019
62CSNK1G30.94857171
63TNK20.94017559
64SCYL20.93305579
65PRKCQ0.91142122
66ALK0.86866385
67ZAP700.86077255
68BRSK20.85061269
69ADRBK10.83267584
70CSNK1G10.83053734
71OXSR10.82385258
72CSNK1G20.81323256
73IRAK40.80102038
74CDC70.79361744
75TGFBR20.78938823
76IRAK10.78503112
77FGFR40.77749027
78CAMKK10.77385995
79MOS0.77072225
80BLK0.76461907
81MAP2K60.76293345
82MAPK40.75359739
83EPHB10.74640000
84PRKCE0.74408842
85MAPKAPK30.73785384
86DDR20.73468046
87CDK70.73312596
88TRPM70.70091452
89PIM10.69999866
90CSNK1A1L0.69757097
91ITK0.67329396
92BMPR20.67130446
93PAK20.63609897
94FER0.62746782
95HCK0.61789560
96BCKDK0.60500920
97MKNK10.60349016
98PASK0.59741070
99PAK40.58806870
100TYK20.58224102
101MATK0.57791628
102MAP3K80.57470093
103ABL20.57026717
104TAOK30.55734577
105PLK20.55323748
106DYRK30.54953886
107LYN0.53012985
108MAP3K20.52872648
109CDK40.51729902
110BRD40.50285241
111MKNK20.49244361
112RPS6KC10.49201520
113RPS6KL10.49201520
114RPS6KA60.49201341
115LCK0.48823691
116ERBB30.48691800
117HIPK20.48406629
118CDK60.46840822
119PRKG20.45865561
120MAPKAPK20.45470028
121PRKCI0.45351338
122PKN10.45145943
123MARK30.44390521
124SIK10.42401439
125MAP2K30.41648898
126ATR0.41206578
127CHUK0.40672141
128MAPKAPK50.40295866
129PRKCG0.40164295
130MAP2K10.39874329
131AURKB0.39804593
132MAP3K40.39619746
133DYRK1B0.39240895
134LMTK20.39046351
135PAK10.38541688
136PAK30.38391946
137TESK20.37968320
138DAPK10.37925633
139ABL10.37730532
140PDGFRA0.37642099
141TGFBR10.37256201
142MAPK110.37251711
143NEK10.36183976
144FGR0.35835550
145LIMK10.35695829
146CSK0.35425861
147IGF1R0.35251383
148TBK10.34720406
149JAK10.33570086
150GRK50.33304773
151JAK30.32962988
152CAMK40.32902026
153MAP3K70.32803884
154TNIK0.32626693
155MST40.32589749
156CSNK1A10.32221899
157STK40.31545573
158PRKCA0.31377891
159TAOK10.31306800
160MUSK0.31101089
161MAPK30.27316416
162JAK20.27098859
163EIF2AK30.26847894
164CDK90.26807005

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.23947313
2DNA replication_Homo sapiens_hsa030304.19363206
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.59033464
4Primary immunodeficiency_Homo sapiens_hsa053403.09393339
5Asthma_Homo sapiens_hsa053103.03007590
6Non-homologous end-joining_Homo sapiens_hsa034503.00577715
7Mismatch repair_Homo sapiens_hsa034302.99379046
8Rheumatoid arthritis_Homo sapiens_hsa053232.81021567
9Allograft rejection_Homo sapiens_hsa053302.63172039
10Lysosome_Homo sapiens_hsa041422.52553007
11Graft-versus-host disease_Homo sapiens_hsa053322.39570558
12Hematopoietic cell lineage_Homo sapiens_hsa046402.38266518
13Homologous recombination_Homo sapiens_hsa034402.33352214
14B cell receptor signaling pathway_Homo sapiens_hsa046622.32421019
15Autoimmune thyroid disease_Homo sapiens_hsa053202.31036730
16Systemic lupus erythematosus_Homo sapiens_hsa053222.27914986
17Type I diabetes mellitus_Homo sapiens_hsa049402.23270843
18Platelet activation_Homo sapiens_hsa046112.14941021
19Staphylococcus aureus infection_Homo sapiens_hsa051502.09508718
20p53 signaling pathway_Homo sapiens_hsa041152.05348588
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05235993
22Base excision repair_Homo sapiens_hsa034102.04024421
23Collecting duct acid secretion_Homo sapiens_hsa049661.95471705
24N-Glycan biosynthesis_Homo sapiens_hsa005101.93517685
25Cell cycle_Homo sapiens_hsa041101.86080808
26Small cell lung cancer_Homo sapiens_hsa052221.82174587
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.81982457
28ECM-receptor interaction_Homo sapiens_hsa045121.73883762
29Leishmaniasis_Homo sapiens_hsa051401.71656689
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.71632205
31Tryptophan metabolism_Homo sapiens_hsa003801.70523332
32Osteoclast differentiation_Homo sapiens_hsa043801.66264278
33Phototransduction_Homo sapiens_hsa047441.62530293
34Linoleic acid metabolism_Homo sapiens_hsa005911.52933847
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50029552
36Antigen processing and presentation_Homo sapiens_hsa046121.49045251
37Other glycan degradation_Homo sapiens_hsa005111.45391730
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43324384
39Chronic myeloid leukemia_Homo sapiens_hsa052201.41497361
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.41097589
41Ether lipid metabolism_Homo sapiens_hsa005651.40513001
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39394164
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.38355718
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36787153
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35868582
46Butanoate metabolism_Homo sapiens_hsa006501.34778633
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31491165
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29586126
49Shigellosis_Homo sapiens_hsa051311.24336562
50Pentose phosphate pathway_Homo sapiens_hsa000301.24129966
51Viral carcinogenesis_Homo sapiens_hsa052031.20808956
52Alcoholism_Homo sapiens_hsa050341.16656468
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15854003
54Measles_Homo sapiens_hsa051621.14238175
55African trypanosomiasis_Homo sapiens_hsa051431.14066453
56Acute myeloid leukemia_Homo sapiens_hsa052211.10557569
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09135136
58Phagosome_Homo sapiens_hsa041451.08263489
59Toxoplasmosis_Homo sapiens_hsa051451.07721213
60Hepatitis B_Homo sapiens_hsa051611.06294210
61Colorectal cancer_Homo sapiens_hsa052101.05651696
62Spliceosome_Homo sapiens_hsa030401.04097361
63Nitrogen metabolism_Homo sapiens_hsa009101.03609537
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02030922
65Selenocompound metabolism_Homo sapiens_hsa004501.02001417
66Legionellosis_Homo sapiens_hsa051341.00909413
67Apoptosis_Homo sapiens_hsa042100.99941290
68Sulfur metabolism_Homo sapiens_hsa009200.99834369
69Mineral absorption_Homo sapiens_hsa049780.99136569
70Sphingolipid metabolism_Homo sapiens_hsa006000.98346502
71Thyroid cancer_Homo sapiens_hsa052160.96156252
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95510339
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95493213
74T cell receptor signaling pathway_Homo sapiens_hsa046600.94285478
75Pyrimidine metabolism_Homo sapiens_hsa002400.93721999
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92294529
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.92011907
78One carbon pool by folate_Homo sapiens_hsa006700.90913215
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90585427
80Pertussis_Homo sapiens_hsa051330.90103939
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89842986
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.88204245
83Epstein-Barr virus infection_Homo sapiens_hsa051690.87471006
84Peroxisome_Homo sapiens_hsa041460.87342349
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87020537
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86250226
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85394995
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85250246
89Herpes simplex infection_Homo sapiens_hsa051680.84550275
90Caffeine metabolism_Homo sapiens_hsa002320.83101116
91Influenza A_Homo sapiens_hsa051640.82620181
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79173936
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78963522
94Folate biosynthesis_Homo sapiens_hsa007900.78654263
95Biosynthesis of amino acids_Homo sapiens_hsa012300.78573424
96Oxidative phosphorylation_Homo sapiens_hsa001900.78447010
97Proteoglycans in cancer_Homo sapiens_hsa052050.75811810
98Arachidonic acid metabolism_Homo sapiens_hsa005900.75726935
99Non-small cell lung cancer_Homo sapiens_hsa052230.75438276
100Pancreatic cancer_Homo sapiens_hsa052120.74564728
101ABC transporters_Homo sapiens_hsa020100.74513037
102Tuberculosis_Homo sapiens_hsa051520.73831263
103RNA polymerase_Homo sapiens_hsa030200.73223253
104Salmonella infection_Homo sapiens_hsa051320.72145365
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72025908
106MicroRNAs in cancer_Homo sapiens_hsa052060.71574195
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71153276
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70993277
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.69981841
110Nucleotide excision repair_Homo sapiens_hsa034200.69881323
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69669889
112HTLV-I infection_Homo sapiens_hsa051660.69434683
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.69133095
114Dorso-ventral axis formation_Homo sapiens_hsa043200.69130069
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68106189
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.67642734
117Malaria_Homo sapiens_hsa051440.65501779
118Salivary secretion_Homo sapiens_hsa049700.64511801
119Focal adhesion_Homo sapiens_hsa045100.64087555
120Regulation of autophagy_Homo sapiens_hsa041400.62887184
121Chemical carcinogenesis_Homo sapiens_hsa052040.62876652
122VEGF signaling pathway_Homo sapiens_hsa043700.62435690
123Morphine addiction_Homo sapiens_hsa050320.62241986
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61742114
125Arginine and proline metabolism_Homo sapiens_hsa003300.61377863
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60140920
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59676919
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59180369
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57342197
130Sulfur relay system_Homo sapiens_hsa041220.55868913
131Fanconi anemia pathway_Homo sapiens_hsa034600.54644630
132Glycerolipid metabolism_Homo sapiens_hsa005610.53420926
133Olfactory transduction_Homo sapiens_hsa047400.52606697
134Hepatitis C_Homo sapiens_hsa051600.49250305
135Bladder cancer_Homo sapiens_hsa052190.48770470
136TNF signaling pathway_Homo sapiens_hsa046680.48167526
137Viral myocarditis_Homo sapiens_hsa054160.48105605
138Taste transduction_Homo sapiens_hsa047420.46631634
139FoxO signaling pathway_Homo sapiens_hsa040680.45116758
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44789799
141Ovarian steroidogenesis_Homo sapiens_hsa049130.43660080
142NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43622374
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42644791
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41884269
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.40601901
146Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40582396
147Amoebiasis_Homo sapiens_hsa051460.40253990
148Pathways in cancer_Homo sapiens_hsa052000.39292321
149Complement and coagulation cascades_Homo sapiens_hsa046100.39014646
150Retinol metabolism_Homo sapiens_hsa008300.36449892
151beta-Alanine metabolism_Homo sapiens_hsa004100.36063984
152Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35517805
153Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35474959
154Chemokine signaling pathway_Homo sapiens_hsa040620.35190802
155Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33883730
156Serotonergic synapse_Homo sapiens_hsa047260.33526013
157Glioma_Homo sapiens_hsa052140.33063687
158PPAR signaling pathway_Homo sapiens_hsa033200.33033566
159Prolactin signaling pathway_Homo sapiens_hsa049170.30511208
160Thyroid hormone synthesis_Homo sapiens_hsa049180.29255598
161Purine metabolism_Homo sapiens_hsa002300.28790600
162Basal transcription factors_Homo sapiens_hsa030220.28772654
163Renin secretion_Homo sapiens_hsa049240.27867924
164Synaptic vesicle cycle_Homo sapiens_hsa047210.27110752
165Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27011755
166Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26887037
167HIF-1 signaling pathway_Homo sapiens_hsa040660.26576135

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