SIGLEC16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)5.52640607
2neutrophil activation involved in immune response (GO:0002283)5.42199466
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.36821438
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.36821438
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.36821438
6modulation by symbiont of host immune response (GO:0052553)5.36821438
7positive regulation by symbiont of host defense response (GO:0052509)5.36821438
8modulation by symbiont of host defense response (GO:0052031)5.36821438
9negative regulation of interleukin-12 production (GO:0032695)5.17924622
10positive regulation of gamma-delta T cell activation (GO:0046645)5.15817336
11macrophage activation involved in immune response (GO:0002281)4.99417743
12negative regulation of cell killing (GO:0031342)4.91662342
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.91662342
14detection of other organism (GO:0098543)4.62411079
15detection of molecule of bacterial origin (GO:0032490)4.46466501
16detection of bacterium (GO:0016045)4.38186776
17immunoglobulin mediated immune response (GO:0016064)4.35993453
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.25752985
19detection of external biotic stimulus (GO:0098581)4.20331745
20regulation of mast cell degranulation (GO:0043304)4.04517598
21regulation of interferon-beta biosynthetic process (GO:0045357)4.02304825
22antigen processing and presentation of endogenous antigen (GO:0019883)3.99020729
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.97105749
24cellular extravasation (GO:0045123)3.85059700
25microglial cell activation (GO:0001774)3.82605259
26positive regulation of mast cell activation (GO:0033005)3.82008880
27detection of biotic stimulus (GO:0009595)3.73424336
28regulation of mast cell activation involved in immune response (GO:0033006)3.72184945
29regulation of myeloid leukocyte mediated immunity (GO:0002886)3.71164817
30myeloid cell activation involved in immune response (GO:0002275)3.69481321
31macrophage activation (GO:0042116)3.69174173
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.68622172
33respiratory burst (GO:0045730)3.68514964
34neutrophil activation (GO:0042119)3.68267891
35granulocyte activation (GO:0036230)3.66921346
36regulation of gamma-delta T cell activation (GO:0046643)3.65827860
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.62679053
38response to host immune response (GO:0052572)3.62679053
39leukocyte aggregation (GO:0070486)3.58672446
40regulation of B cell receptor signaling pathway (GO:0050855)3.53877415
41regulation of mast cell activation (GO:0033003)3.52968033
42regulation of leukocyte degranulation (GO:0043300)3.51790006
43positive regulation of mast cell degranulation (GO:0043306)3.51179000
44positive regulation of mast cell activation involved in immune response (GO:0033008)3.51179000
45response to muramyl dipeptide (GO:0032495)3.38775309
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34050935
47positive regulation of antigen processing and presentation (GO:0002579)3.31632741
48leukocyte migration involved in inflammatory response (GO:0002523)3.30973060
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.30656466
50interferon-gamma-mediated signaling pathway (GO:0060333)3.30256057
51lipopolysaccharide-mediated signaling pathway (GO:0031663)3.29850631
52regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.25788785
53negative regulation of erythrocyte differentiation (GO:0045647)3.25662311
54cellular response to type I interferon (GO:0071357)3.25583286
55type I interferon signaling pathway (GO:0060337)3.25583286
56negative regulation of cytokine production involved in immune response (GO:0002719)3.25217294
57response to type I interferon (GO:0034340)3.24975519
58response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21838095
59response to host (GO:0075136)3.21838095
60response to host defenses (GO:0052200)3.21838095
61B cell mediated immunity (GO:0019724)3.21426845
62regulation of interferon-alpha production (GO:0032647)3.17066522
63regulation of antigen processing and presentation (GO:0002577)3.16939001
64positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.16767298
65negative regulation of T cell mediated immunity (GO:0002710)3.15349172
66germinal center formation (GO:0002467)3.13804098
67defense response to protozoan (GO:0042832)3.12535689
68positive regulation of cellular amide metabolic process (GO:0034250)3.12259434
69positive regulation of interferon-alpha production (GO:0032727)3.09038366
70regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07398112
71negative regulation of leukocyte mediated immunity (GO:0002704)3.06605644
72mannose metabolic process (GO:0006013)3.03954490
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.03949713
74amino sugar catabolic process (GO:0046348)2.97199469
75regulation of regulated secretory pathway (GO:1903305)2.93195032
76production of molecular mediator involved in inflammatory response (GO:0002532)2.92855904
77regulation of tolerance induction (GO:0002643)2.92706477
78regulation of T cell tolerance induction (GO:0002664)2.91377995
79response to protozoan (GO:0001562)2.86972865
80negative regulation of innate immune response (GO:0045824)2.83688512
81hydrogen peroxide biosynthetic process (GO:0050665)2.81550715
82regulation of T-helper 2 cell differentiation (GO:0045628)2.80830689
83leukocyte degranulation (GO:0043299)2.78630073
84positive regulation of toll-like receptor signaling pathway (GO:0034123)2.78621496
85negative regulation of interleukin-6 production (GO:0032715)2.78035937
86positive regulation of type 2 immune response (GO:0002830)2.77425234
87negative regulation of toll-like receptor signaling pathway (GO:0034122)2.77238695
88positive regulation of leukocyte degranulation (GO:0043302)2.76403110
89myeloid leukocyte activation (GO:0002274)2.76359129
90T-helper 1 type immune response (GO:0042088)2.73771917
91N-acetylneuraminate metabolic process (GO:0006054)2.71964129
92positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.69203399
93neutrophil chemotaxis (GO:0030593)2.69059660
94regulation of gamma-delta T cell differentiation (GO:0045586)2.68344806
95regulation of toll-like receptor signaling pathway (GO:0034121)2.67893623
96regulation of interleukin-8 biosynthetic process (GO:0045414)2.67464172
97positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.66354566
98regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.66336877
99B cell receptor signaling pathway (GO:0050853)2.65388060
100neutrophil mediated immunity (GO:0002446)2.64916462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.77258882
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.09833047
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.72501148
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.38656212
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20007571
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.15424011
7VDR_21846776_ChIP-Seq_THP-1_Human3.11341282
8* VDR_24763502_ChIP-Seq_THP-1_Human2.79138919
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78178994
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64968166
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.60408369
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58568938
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40562474
14SPI1_23127762_ChIP-Seq_K562_Human2.35406271
15SPI1_23547873_ChIP-Seq_NB4_Human2.33218055
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19037683
17SCL_19346495_ChIP-Seq_HPC-7_Human2.17683040
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.11481050
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10289102
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05754050
21* MAF_26560356_Chip-Seq_TH1_Human2.00814103
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00614586
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00256950
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96895583
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96585222
26VDR_24787735_ChIP-Seq_THP-1_Human1.94162724
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.90832518
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87915481
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85671729
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83886702
31LXR_22292898_ChIP-Seq_THP-1_Human1.82272940
32UTX_26944678_Chip-Seq_JUKART_Human1.78636715
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77469434
34MAF_26560356_Chip-Seq_TH2_Human1.76993252
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76052625
36RUNX_20019798_ChIP-Seq_JUKART_Human1.72710407
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71334243
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66637789
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65581157
40KDM2B_26808549_Chip-Seq_DND41_Human1.63829544
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61551499
42MYB_26560356_Chip-Seq_TH2_Human1.61191735
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58036110
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.53065428
45TCF7_22412390_ChIP-Seq_EML_Mouse1.51442839
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49536552
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48381514
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45812782
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45686004
50BCL6_27268052_Chip-Seq_Bcells_Human1.44194435
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42743794
52BCOR_27268052_Chip-Seq_Bcells_Human1.42644152
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41028426
54MYC_22102868_ChIP-Seq_BL_Human1.38490959
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36672705
56MYB_26560356_Chip-Seq_TH1_Human1.36603561
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36375406
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.35622156
59GATA1_22025678_ChIP-Seq_K562_Human1.35564863
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30847874
61CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30531511
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29660950
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.28217883
64SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27825821
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23001416
66GATA3_27048872_Chip-Seq_THYMUS_Human1.21830351
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21663180
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20941267
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19736319
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19410858
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17220404
72PU_27001747_Chip-Seq_BMDM_Mouse1.15881075
73GATA1_19941826_ChIP-Seq_K562_Human1.14778851
74P68_20966046_ChIP-Seq_HELA_Human1.10479541
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10299591
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10298168
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08346637
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07505798
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06845788
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06371799
81GATA3_26560356_Chip-Seq_TH2_Human1.06350469
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05507395
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05126237
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.05088971
85* SPI1_20517297_ChIP-Seq_HL60_Human1.04970094
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04663864
87E2F1_20622854_ChIP-Seq_HELA_Human1.03057937
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02083119
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.00703478
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00667282
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98634657
92STAT1_20625510_ChIP-Seq_HELA_Human0.96635759
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95835994
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95371758
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94207100
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93997577
97PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91569505
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.91326707
99SMAD_19615063_ChIP-ChIP_OVARY_Human0.90277280
100SA1_27219007_Chip-Seq_ERYTHROID_Human0.88116469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.19959742
2MP0003724_increased_susceptibility_to4.16013946
3MP0003436_decreased_susceptibility_to3.70684086
4MP0001835_abnormal_antigen_presentation3.51741422
5MP0006082_CNS_inflammation3.38660594
6MP0005058_abnormal_lysosome_morphology3.14704418
7MP0002419_abnormal_innate_immunity3.13911510
8MP0009785_altered_susceptibility_to3.02435962
9MP0005671_abnormal_response_to2.85363039
10MP0005025_abnormal_response_to2.81846027
11MP0005387_immune_system_phenotype2.75029647
12MP0001790_abnormal_immune_system2.75029647
13MP0002148_abnormal_hypersensitivity_rea2.72110089
14MP0005000_abnormal_immune_tolerance2.62144656
15MP0003172_abnormal_lysosome_physiology2.51499954
16MP0001800_abnormal_humoral_immune2.43650808
17MP0000685_abnormal_immune_system2.38940847
18MP0002723_abnormal_immune_serum2.38520087
19MP0002452_abnormal_antigen_presenting2.35873039
20MP0002420_abnormal_adaptive_immunity2.14675909
21MP0001819_abnormal_immune_cell2.14450589
22MP0003806_abnormal_nucleotide_metabolis2.10073030
23MP0001986_abnormal_taste_sensitivity2.05228820
24MP0001533_abnormal_skeleton_physiology2.04072259
25MP0003300_gastrointestinal_ulcer2.00845022
26MP0005464_abnormal_platelet_physiology1.91937559
27MP0004510_myositis1.90846708
28MP0009840_abnormal_foam_cell1.84309448
29MP0001845_abnormal_inflammatory_respons1.81430378
30MP0009278_abnormal_bone_marrow1.81192763
31MP0003191_abnormal_cellular_cholesterol1.80518833
32MP0000343_altered_response_to1.75493606
33MP0002405_respiratory_system_inflammati1.73849569
34MP0003075_altered_response_to1.69433098
35MP0009764_decreased_sensitivity_to1.68718097
36MP0010155_abnormal_intestine_physiology1.64933783
37MP0008469_abnormal_protein_level1.63574267
38MP0002254_reproductive_system_inflammat1.62153672
39MP0003828_pulmonary_edema1.53832336
40MP0005397_hematopoietic_system_phenotyp1.53814333
41MP0001545_abnormal_hematopoietic_system1.53814333
42MP0000604_amyloidosis1.52101944
43MP0005310_abnormal_salivary_gland1.51843090
44MP0000716_abnormal_immune_system1.49023281
45MP0002998_abnormal_bone_remodeling1.46098034
46MP0008004_abnormal_stomach_pH1.39091772
47MP0009333_abnormal_splenocyte_physiolog1.37194385
48MP0003690_abnormal_glial_cell1.36138388
49MP0002398_abnormal_bone_marrow1.34568726
50MP0004947_skin_inflammation1.32008930
51MP0008260_abnormal_autophagy1.29146673
52MP0004883_abnormal_blood_vessel1.27213699
53MP0002132_abnormal_respiratory_system1.26986465
54MP0000465_gastrointestinal_hemorrhage1.25310947
55MP0005166_decreased_susceptibility_to1.24681886
56MP0000689_abnormal_spleen_morphology1.24672533
57MP0005174_abnormal_tail_pigmentation1.23761877
58MP0005167_abnormal_blood-brain_barrier1.19844437
59MP0002277_abnormal_respiratory_mucosa1.17138711
60MP0002429_abnormal_blood_cell1.13974643
61MP0002722_abnormal_immune_system1.12601468
62MP0000858_altered_metastatic_potential1.10433466
63MP0003448_altered_tumor_morphology1.08253081
64MP0003763_abnormal_thymus_physiology1.05495118
65MP0005451_abnormal_body_composition1.05045445
66MP0001853_heart_inflammation1.04690943
67MP0003866_abnormal_defecation1.01035577
68MP0002139_abnormal_hepatobiliary_system0.99939979
69MP0005164_abnormal_response_to0.96494435
70MP0001663_abnormal_digestive_system0.96372579
71MP0003656_abnormal_erythrocyte_physiolo0.95332433
72MP0006054_spinal_hemorrhage0.94559878
73MP0002138_abnormal_hepatobiliary_system0.87858860
74MP0003453_abnormal_keratinocyte_physiol0.85184669
75MP0004381_abnormal_hair_follicle0.81703184
76MP0003183_abnormal_peptide_metabolism0.81083506
77MP0001851_eye_inflammation0.80544717
78MP0000015_abnormal_ear_pigmentation0.76439692
79MP0001873_stomach_inflammation0.76146744
80MP0005083_abnormal_biliary_tract0.75102400
81MP0009763_increased_sensitivity_to0.74709834
82MP0000920_abnormal_myelination0.74113423
83MP0008874_decreased_physiological_sensi0.70919894
84MP0005390_skeleton_phenotype0.69868184
85MP0000703_abnormal_thymus_morphology0.69274662
86MP0004130_abnormal_muscle_cell0.68399294
87MP0005365_abnormal_bile_salt0.65724046
88MP0003329_amyloid_beta_deposits0.64681791
89MP0000490_abnormal_crypts_of0.63770247
90MP0003795_abnormal_bone_structure0.61266907
91MP0002332_abnormal_exercise_endurance0.60073259
92MP0003091_abnormal_cell_migration0.59967256
93MP0005319_abnormal_enzyme/_coenzyme0.57148351
94MP0002933_joint_inflammation0.56689710
95MP0000249_abnormal_blood_vessel0.54992090
96MP0005334_abnormal_fat_pad0.54012552
97MP0005076_abnormal_cell_differentiation0.53726102
98MP0002693_abnormal_pancreas_physiology0.53279868
99MP0005584_abnormal_enzyme/coenzyme_acti0.51733878
100MP0001756_abnormal_urination0.51492923

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.90068988
2Recurrent bacterial skin infections (HP:0005406)5.68171804
3Eczematoid dermatitis (HP:0000976)5.66019322
4Abnormality of macrophages (HP:0004311)5.55196721
5Abnormality of liposaccharide metabolism (HP:0010968)4.97256471
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.97256471
7Abnormality of glycolipid metabolism (HP:0010969)4.97256471
8Recurrent gram-negative bacterial infections (HP:0005420)4.84430937
9Myositis (HP:0100614)4.70668660
10Stomatitis (HP:0010280)4.48333906
11Orchitis (HP:0100796)4.46429775
12Optic neuritis (HP:0100653)4.32639912
13Retrobulbar optic neuritis (HP:0100654)4.32639912
14Increased cerebral lipofuscin (HP:0011813)4.16498130
15Obstructive lung disease (HP:0006536)3.93477547
16Chronic obstructive pulmonary disease (HP:0006510)3.93477547
17Mediastinal lymphadenopathy (HP:0100721)3.78190032
18Recurrent skin infections (HP:0001581)3.71508184
19Recurrent fungal infections (HP:0002841)3.56674919
20Systemic lupus erythematosus (HP:0002725)3.55464531
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.48319584
22Elevated erythrocyte sedimentation rate (HP:0003565)3.47010607
23Chronic mucocutaneous candidiasis (HP:0002728)3.42719736
24Recurrent cutaneous fungal infections (HP:0011370)3.42719736
25Disinhibition (HP:0000734)3.37087491
26Spontaneous hematomas (HP:0007420)3.36891476
27Meningitis (HP:0001287)3.21919947
28Dysostosis multiplex (HP:0000943)3.20683367
29Vacuolated lymphocytes (HP:0001922)3.19987561
30Petechiae (HP:0000967)3.19887003
31Gastrointestinal infarctions (HP:0005244)3.14586786
32Purpura (HP:0000979)3.10117732
33Gingivitis (HP:0000230)3.06841941
34Loss of speech (HP:0002371)2.98544244
35Keratoconjunctivitis sicca (HP:0001097)2.96838548
36Encephalitis (HP:0002383)2.89142748
37Keratoconjunctivitis (HP:0001096)2.87898590
38Amyloidosis (HP:0011034)2.82201690
39Hemoptysis (HP:0002105)2.81739627
40Abnormality of mucopolysaccharide metabolism (HP:0011020)2.80653819
41Abnormality of polysaccharide metabolism (HP:0011012)2.80653819
42Abnormality of glycosaminoglycan metabolism (HP:0004371)2.80653819
43Vasculitis (HP:0002633)2.78299112
44Urticaria (HP:0001025)2.74459163
45Chronic otitis media (HP:0000389)2.72636972
46Prolonged bleeding time (HP:0003010)2.71960643
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.70257744
48Mutism (HP:0002300)2.65300891
49Epistaxis (HP:0000421)2.60491428
50Autoimmune thrombocytopenia (HP:0001973)2.59783608
51Pulmonary infiltrates (HP:0002113)2.59245095
52Inflammation of the large intestine (HP:0002037)2.55080837
53Gingival bleeding (HP:0000225)2.50224095
54Mucopolysacchariduria (HP:0008155)2.49451399
55Urinary glycosaminoglycan excretion (HP:0003541)2.49451399
56Anorexia (HP:0002039)2.46477416
57Increased serum ferritin (HP:0003281)2.43183459
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.38872197
59Gastrointestinal inflammation (HP:0004386)2.38575596
60Recurrent viral infections (HP:0004429)2.36915605
61Chest pain (HP:0100749)2.32815125
62Arterial thrombosis (HP:0004420)2.32613072
63Glomerulonephritis (HP:0000099)2.32114064
64Cellulitis (HP:0100658)2.29211652
65Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28777836
66Leukocytosis (HP:0001974)2.28620485
67Increased IgE level (HP:0003212)2.27332758
68Colitis (HP:0002583)2.27311249
69Episodic fever (HP:0001954)2.23138907
70Hematochezia (HP:0002573)2.22403586
71Pustule (HP:0200039)2.20618735
72Abnormality of iron homeostasis (HP:0011031)2.19330065
73Pulmonary embolism (HP:0002204)2.17777847
74Joint hemorrhage (HP:0005261)2.17446563
75Basal ganglia calcification (HP:0002135)2.17272936
76Osteomyelitis (HP:0002754)2.14606041
77Hypochromic anemia (HP:0001931)2.13924841
78Axonal loss (HP:0003447)2.12556356
79Polyneuropathy (HP:0001271)2.12509358
80Malnutrition (HP:0004395)2.09599982
81Increased IgM level (HP:0003496)2.08845645
82Cheilitis (HP:0100825)2.07147440
83Global brain atrophy (HP:0002283)2.00222746
84Inappropriate behavior (HP:0000719)1.99860195
85Hepatosplenomegaly (HP:0001433)1.96107896
86Upper motor neuron abnormality (HP:0002127)1.95802527
87T lymphocytopenia (HP:0005403)1.94885397
88Hypochromic microcytic anemia (HP:0004840)1.93823150
89Acne (HP:0001061)1.90721542
90Abnormality of T cell number (HP:0011839)1.90420224
91Abnormality of the vasculature of the conjunctiva (HP:0008054)1.87950291
92Vertigo (HP:0002321)1.86596633
93Asymmetric septal hypertrophy (HP:0001670)1.80865802
94Abnormality of transition element cation homeostasis (HP:0011030)1.80099232
95Abnormality of the endocardium (HP:0004306)1.79104859
96Neuronal loss in central nervous system (HP:0002529)1.78550443
97Gangrene (HP:0100758)1.77653925
98Agnosia (HP:0010524)1.77395559
99Memory impairment (HP:0002354)1.77295558
100Choroideremia (HP:0001139)1.77007478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.70987813
2BLK4.07507984
3MAP4K12.84380738
4TYK22.79479118
5MAP2K32.60152588
6IRAK42.54378326
7CSK2.48768278
8TESK22.38255015
9ERN12.16436507
10MAP3K132.08179567
11TNK22.04036529
12FES2.02241351
13FGR1.96713688
14PRPF4B1.91942809
15EPHB11.83393440
16ZAP701.82724876
17MAP3K141.82207928
18MAP3K31.79791220
19TAOK11.78498866
20TBK11.77608921
21MAP3K111.71341414
22SYK1.63568232
23JAK31.57770446
24BTK1.54796190
25IKBKE1.52538588
26TGFBR21.50899852
27GRK61.50602312
28TAOK21.49365190
29CSF1R1.48959431
30MARK31.46275911
31MATK1.36215269
32LYN1.34361397
33KIT1.34036231
34HCK1.31317414
35GRK71.30063334
36IKBKB1.28227078
37TXK1.23837231
38MAP3K11.22265365
39ACVR1B1.22012569
40PINK11.14055956
41JAK11.11549301
42JAK21.10695610
43MAPK151.10542633
44PDPK11.08413441
45TAOK31.06740857
46SIK30.98422705
47LCK0.97663764
48CAMKK20.97659407
49PDK10.97569943
50NME20.96127702
51CDC42BPA0.91450861
52IRAK30.90692413
53MOS0.87322307
54MARK20.85337191
55SIK20.85290020
56ADRBK20.83677462
57BMPR20.78183261
58ITK0.76962482
59TEC0.76577016
60DAPK20.73936009
61IRAK20.73782990
62MAPK120.73665700
63PRKD20.72621808
64KSR20.72533589
65MAP3K50.65934606
66MAPK70.63280018
67DYRK30.59079933
68CAMK1D0.58302543
69RIPK10.58090271
70RPS6KL10.57715563
71RPS6KC10.57715563
72RPS6KA60.56718622
73BRAF0.56481265
74RPS6KA20.56387752
75PRKCQ0.55776043
76SGK30.52384569
77YES10.51206136
78SGK20.50564455
79STK100.49755285
80MAP2K20.49731256
81MAP3K70.48951075
82FYN0.46742080
83DYRK1B0.41221566
84HIPK20.41058865
85IRAK10.40072568
86MAP2K60.37098040
87PTK60.36975522
88STK110.33981072
89SGK4940.33392385
90SGK2230.33392385
91KSR10.31381735
92STK380.31152007
93FRK0.30924649
94CHUK0.30743852
95TRIB30.28456596
96PRKG20.28182544
97MAP3K80.28121840
98ABL10.27814416
99CAMK40.26632346
100PRKAA20.26540513

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.41731209
2Osteoclast differentiation_Homo sapiens_hsa043803.07104355
3Other glycan degradation_Homo sapiens_hsa005113.03488066
4Leishmaniasis_Homo sapiens_hsa051402.95088298
5Allograft rejection_Homo sapiens_hsa053302.32411012
6Tuberculosis_Homo sapiens_hsa051522.30573113
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.28083560
8Graft-versus-host disease_Homo sapiens_hsa053322.16405205
9Lysosome_Homo sapiens_hsa041422.15912558
10Autoimmune thyroid disease_Homo sapiens_hsa053202.04375056
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01588532
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93214424
13Asthma_Homo sapiens_hsa053101.92936390
14Malaria_Homo sapiens_hsa051441.92782626
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90632337
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.88560587
17B cell receptor signaling pathway_Homo sapiens_hsa046621.85626218
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.75761383
19Rheumatoid arthritis_Homo sapiens_hsa053231.75513479
20Hematopoietic cell lineage_Homo sapiens_hsa046401.73076572
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.67873212
22Phagosome_Homo sapiens_hsa041451.63824793
23Legionellosis_Homo sapiens_hsa051341.63455618
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59936407
25Type I diabetes mellitus_Homo sapiens_hsa049401.57323149
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57256621
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56848787
28Antigen processing and presentation_Homo sapiens_hsa046121.54970414
29Pertussis_Homo sapiens_hsa051331.50318795
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49368558
31Chemokine signaling pathway_Homo sapiens_hsa040621.44761045
32Influenza A_Homo sapiens_hsa051641.43042611
33Toxoplasmosis_Homo sapiens_hsa051451.42331918
34Primary immunodeficiency_Homo sapiens_hsa053401.37210584
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33671910
36TNF signaling pathway_Homo sapiens_hsa046681.32146307
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32071459
38Measles_Homo sapiens_hsa051621.29712552
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27188445
40African trypanosomiasis_Homo sapiens_hsa051431.24959260
41Viral myocarditis_Homo sapiens_hsa054161.19391888
42Herpes simplex infection_Homo sapiens_hsa051681.17040723
43Acute myeloid leukemia_Homo sapiens_hsa052211.15540481
44Salmonella infection_Homo sapiens_hsa051321.11550760
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.08740097
46T cell receptor signaling pathway_Homo sapiens_hsa046601.07747114
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99298602
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97064656
49Platelet activation_Homo sapiens_hsa046110.94214246
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92549200
51Hepatitis B_Homo sapiens_hsa051610.90045973
52Hepatitis C_Homo sapiens_hsa051600.88774276
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79522559
54Apoptosis_Homo sapiens_hsa042100.77515304
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.73189773
56Complement and coagulation cascades_Homo sapiens_hsa046100.71092691
57Collecting duct acid secretion_Homo sapiens_hsa049660.69466936
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.67722394
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.67273790
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64181677
61VEGF signaling pathway_Homo sapiens_hsa043700.64179676
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63315919
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.62102162
64Endocytosis_Homo sapiens_hsa041440.61756068
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59303810
66Shigellosis_Homo sapiens_hsa051310.58053671
67Non-small cell lung cancer_Homo sapiens_hsa052230.56305405
68Prolactin signaling pathway_Homo sapiens_hsa049170.55545406
69Sphingolipid metabolism_Homo sapiens_hsa006000.54641717
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53053232
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52928406
72Amoebiasis_Homo sapiens_hsa051460.52222574
73Prion diseases_Homo sapiens_hsa050200.51911539
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50971891
75Bladder cancer_Homo sapiens_hsa052190.50782369
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44218414
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.43896965
78Notch signaling pathway_Homo sapiens_hsa043300.43345379
79GnRH signaling pathway_Homo sapiens_hsa049120.42290078
80Insulin resistance_Homo sapiens_hsa049310.41763481
81Type II diabetes mellitus_Homo sapiens_hsa049300.41674062
82FoxO signaling pathway_Homo sapiens_hsa040680.40506089
83mTOR signaling pathway_Homo sapiens_hsa041500.38512360
84MAPK signaling pathway_Homo sapiens_hsa040100.36677404
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36415638
86Dorso-ventral axis formation_Homo sapiens_hsa043200.35505242
87Epstein-Barr virus infection_Homo sapiens_hsa051690.34603785
88Chronic myeloid leukemia_Homo sapiens_hsa052200.34261488
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32654648
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32346635
91PPAR signaling pathway_Homo sapiens_hsa033200.31784476
92Renal cell carcinoma_Homo sapiens_hsa052110.30718149
93Pancreatic cancer_Homo sapiens_hsa052120.29585547
94Mineral absorption_Homo sapiens_hsa049780.29576434
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.26534484
96Ovarian steroidogenesis_Homo sapiens_hsa049130.26113097
97HIF-1 signaling pathway_Homo sapiens_hsa040660.25592609
98Regulation of autophagy_Homo sapiens_hsa041400.24500737
99HTLV-I infection_Homo sapiens_hsa051660.24500599
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22569497

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