SIGLEC17P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.30670341
2positive regulation of gamma-delta T cell activation (GO:0046645)6.20527100
3antigen processing and presentation of endogenous antigen (GO:0019883)5.78354513
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.57628881
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.25238434
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.16108175
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.10760211
8negative regulation of cell killing (GO:0031342)5.10760211
9macrophage activation involved in immune response (GO:0002281)5.03664484
10positive regulation of B cell differentiation (GO:0045579)4.89634414
11detection of bacterium (GO:0016045)4.52455273
12regulation of B cell differentiation (GO:0045577)4.52210468
13regulation of gamma-delta T cell activation (GO:0046643)4.44858711
14detection of other organism (GO:0098543)4.43556354
15regulation of B cell receptor signaling pathway (GO:0050855)4.38239538
16microglial cell activation (GO:0001774)4.32523106
17myeloid cell activation involved in immune response (GO:0002275)4.28118856
18response to peptidoglycan (GO:0032494)4.16091455
19positive regulation by symbiont of host defense response (GO:0052509)4.13738079
20modulation by symbiont of host defense response (GO:0052031)4.13738079
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.13738079
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.13738079
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.13738079
24modulation by symbiont of host immune response (GO:0052553)4.13738079
25regulation of gamma-delta T cell differentiation (GO:0045586)4.13465620
26neutrophil activation (GO:0042119)4.10312808
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.09977276
28immunoglobulin mediated immune response (GO:0016064)4.07578386
29negative regulation of interleukin-12 production (GO:0032695)4.06131968
30response to interleukin-15 (GO:0070672)4.03992550
31negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.90582012
32regulation of mast cell degranulation (GO:0043304)3.88920375
33leukocyte aggregation (GO:0070486)3.85761358
34leukocyte degranulation (GO:0043299)3.85602548
35positive regulation of mast cell activation (GO:0033005)3.79264143
36cellular extravasation (GO:0045123)3.75425793
37cellular response to interleukin-15 (GO:0071350)3.73607822
38negative regulation of lymphocyte mediated immunity (GO:0002707)3.71840268
39negative regulation of T cell mediated immunity (GO:0002710)3.69616807
40granulocyte activation (GO:0036230)3.67988646
41mast cell activation (GO:0045576)3.64438011
42regulation of mast cell activation involved in immune response (GO:0033006)3.60871369
43regulation of dendritic cell antigen processing and presentation (GO:0002604)3.60345820
44positive regulation of mast cell activation involved in immune response (GO:0033008)3.60311714
45positive regulation of mast cell degranulation (GO:0043306)3.60311714
46negative thymic T cell selection (GO:0045060)3.59448340
47positive T cell selection (GO:0043368)3.57141584
48negative T cell selection (GO:0043383)3.57003291
49regulation of mast cell activation (GO:0033003)3.48574695
50positive thymic T cell selection (GO:0045059)3.46761997
51negative regulation of leukocyte mediated immunity (GO:0002704)3.45286937
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.39343894
53negative regulation of T-helper cell differentiation (GO:0045623)3.38702818
54negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.38702818
55histone H4-K12 acetylation (GO:0043983)3.38079098
56mast cell degranulation (GO:0043303)3.35434481
57mast cell activation involved in immune response (GO:0002279)3.35434481
58negative regulation of erythrocyte differentiation (GO:0045647)3.34944831
59B cell receptor signaling pathway (GO:0050853)3.34371073
60regulation of alpha-beta T cell proliferation (GO:0046640)3.33467019
61positive regulation of antigen processing and presentation (GO:0002579)3.32015703
62regulation of leukocyte degranulation (GO:0043300)3.30987712
63T cell selection (GO:0045058)3.29093159
64macrophage activation (GO:0042116)3.26229683
65response to muramyl dipeptide (GO:0032495)3.25902775
66B cell mediated immunity (GO:0019724)3.23713916
67regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.22416947
68regulation of natural killer cell mediated immunity (GO:0002715)3.22416947
69megakaryocyte development (GO:0035855)3.20653056
70positive regulation of granulocyte differentiation (GO:0030854)3.18270106
71defense response to protozoan (GO:0042832)3.16502633
72T cell migration (GO:0072678)3.16278552
73detection of external biotic stimulus (GO:0098581)3.16271405
74Peyers patch development (GO:0048541)3.15684792
75mucosal-associated lymphoid tissue development (GO:0048537)3.15684792
76regulation of T-helper 1 cell differentiation (GO:0045625)3.11893078
77phagocytosis, engulfment (GO:0006911)3.11764176
78response to protozoan (GO:0001562)3.09475061
79positive regulation of alpha-beta T cell proliferation (GO:0046641)3.07013654
80regulation of antigen processing and presentation (GO:0002577)3.07004222
81negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.02753354
82activated T cell proliferation (GO:0050798)3.00619036
83response to host immune response (GO:0052572)3.00020514
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.00020514
85purine deoxyribonucleotide catabolic process (GO:0009155)2.98672539
86respiratory burst (GO:0045730)2.98119610
87negative regulation of innate immune response (GO:0045824)2.95453470
88autophagic vacuole fusion (GO:0000046)2.94311563
89detection of biotic stimulus (GO:0009595)2.90988241
90positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.90642137
91regulation of T cell mediated cytotoxicity (GO:0001914)2.88852672
92interferon-gamma production (GO:0032609)2.88342904
93positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88083357
94cellular defense response (GO:0006968)2.85113803
95positive regulation of type 2 immune response (GO:0002830)2.84946182
96mature B cell differentiation involved in immune response (GO:0002313)2.84819753
97negative regulation of cytokine production involved in immune response (GO:0002719)2.78116725
98positive regulation of interleukin-17 production (GO:0032740)2.77425244
99negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.76166441
100positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.74554219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.84068925
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.77604646
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.62637663
4SCL_19346495_ChIP-Seq_HPC-7_Human3.34335296
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.31837476
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.22761255
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.02816592
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.02185558
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.00691003
10VDR_21846776_ChIP-Seq_THP-1_Human2.95123865
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.94585398
12MYB_26560356_Chip-Seq_TH2_Human2.81768750
13VDR_24763502_ChIP-Seq_THP-1_Human2.79860182
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.79253682
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78888762
16* SPI1_23547873_ChIP-Seq_NB4_Human2.72474496
17RUNX_20019798_ChIP-Seq_JUKART_Human2.70840725
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.64489148
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52183740
20UTX_26944678_Chip-Seq_JUKART_Human2.50970677
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.47566743
22MAF_26560356_Chip-Seq_TH1_Human2.43363484
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41041304
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31213633
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.30181914
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.29310087
27MYC_22102868_ChIP-Seq_BL_Human2.28997849
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28243946
29SPI1_23127762_ChIP-Seq_K562_Human2.26810353
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.24975721
31MYB_26560356_Chip-Seq_TH1_Human2.18996609
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09906932
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04426063
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.04299711
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.01525329
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01129721
37GATA1_22025678_ChIP-Seq_K562_Human1.99561930
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97196375
39GATA3_27048872_Chip-Seq_THYMUS_Human1.92101071
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86545671
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79186195
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78250871
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78035413
44TCF7_22412390_ChIP-Seq_EML_Mouse1.74525052
45MAF_26560356_Chip-Seq_TH2_Human1.74093078
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70561845
47GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.65319217
48VDR_24787735_ChIP-Seq_THP-1_Human1.63139504
49GATA3_26560356_Chip-Seq_TH2_Human1.57784927
50GATA1_19941826_ChIP-Seq_K562_Human1.47066628
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46095704
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45969506
53KDM2B_26808549_Chip-Seq_DND41_Human1.45873313
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40913059
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38432128
56BCL6_27268052_Chip-Seq_Bcells_Human1.37327323
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.36374464
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34594588
59PU.1_20513432_ChIP-Seq_Bcells_Mouse1.33938280
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33830935
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32401632
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.28689986
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27267818
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.27045147
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24496571
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24080672
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21784751
68CIITA_25753668_ChIP-Seq_RAJI_Human1.21209446
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19825461
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19666801
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18359276
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17513067
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16846707
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16388737
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15567396
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14996378
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13231072
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11513495
79PU_27001747_Chip-Seq_BMDM_Mouse1.11370003
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.08322907
81BCOR_27268052_Chip-Seq_Bcells_Human1.08083826
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05799398
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05549554
84RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05495847
85LXR_22292898_ChIP-Seq_THP-1_Human1.04362956
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03801074
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03362037
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99996345
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95923922
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95818255
91GATA2_21666600_ChIP-Seq_HMVEC_Human0.95487185
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94957844
93SA1_27219007_Chip-Seq_ERYTHROID_Human0.94577962
94STAT1_20625510_ChIP-Seq_HELA_Human0.93223615
95SPI1_20517297_ChIP-Seq_HL60_Human0.93215843
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90957931
97P300_27268052_Chip-Seq_Bcells_Human0.88019961
98GATA2_19941826_ChIP-Seq_K562_Human0.86647310
99KDM2B_26808549_Chip-Seq_JURKAT_Human0.86607632
100NCOR1_26117541_ChIP-Seq_K562_Human0.83884187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.40394430
2MP0003436_decreased_susceptibility_to3.71356084
3MP0005671_abnormal_response_to3.69123611
4MP0003724_increased_susceptibility_to3.60375087
5MP0006082_CNS_inflammation3.37701313
6MP0002419_abnormal_innate_immunity2.97130816
7MP0009785_altered_susceptibility_to2.96807128
8MP0005000_abnormal_immune_tolerance2.92304282
9MP0002148_abnormal_hypersensitivity_rea2.87657076
10MP0005025_abnormal_response_to2.86010662
11MP0000685_abnormal_immune_system2.84848797
12MP0001800_abnormal_humoral_immune2.74474192
13MP0003303_peritoneal_inflammation2.71652988
14MP0002420_abnormal_adaptive_immunity2.62998468
15MP0001819_abnormal_immune_cell2.60907515
16MP0002723_abnormal_immune_serum2.59052610
17MP0003763_abnormal_thymus_physiology2.58518776
18MP0002396_abnormal_hematopoietic_system2.57732507
19MP0001790_abnormal_immune_system2.55210529
20MP0005387_immune_system_phenotype2.55210529
21MP0002452_abnormal_antigen_presenting2.55074153
22MP0009278_abnormal_bone_marrow2.52527848
23MP0005464_abnormal_platelet_physiology2.39221592
24MP0008260_abnormal_autophagy2.37760121
25MP0009333_abnormal_splenocyte_physiolog2.27969847
26MP0002398_abnormal_bone_marrow2.16275474
27MP0003191_abnormal_cellular_cholesterol2.14273256
28MP0005397_hematopoietic_system_phenotyp2.09403382
29MP0001545_abnormal_hematopoietic_system2.09403382
30MP0000716_abnormal_immune_system2.04042348
31MP0002405_respiratory_system_inflammati1.96225395
32MP0000465_gastrointestinal_hemorrhage1.91196838
33MP0003300_gastrointestinal_ulcer1.90268694
34MP0000689_abnormal_spleen_morphology1.82398258
35MP0002722_abnormal_immune_system1.80085085
36MP0001533_abnormal_skeleton_physiology1.79834026
37MP0010155_abnormal_intestine_physiology1.77684269
38MP0001845_abnormal_inflammatory_respons1.66205649
39MP0002429_abnormal_blood_cell1.65413216
40MP0000703_abnormal_thymus_morphology1.60973619
41MP0002132_abnormal_respiratory_system1.57664912
42MP0003183_abnormal_peptide_metabolism1.47989560
43MP0004947_skin_inflammation1.46517154
44MP0005075_abnormal_melanosome_morpholog1.40183861
45MP0008469_abnormal_protein_level1.37880231
46MP0003690_abnormal_glial_cell1.34745064
47MP0004808_abnormal_hematopoietic_stem1.30871903
48MP0003172_abnormal_lysosome_physiology1.28031203
49MP0005166_decreased_susceptibility_to1.24101904
50MP0009764_decreased_sensitivity_to1.22018426
51MP0003866_abnormal_defecation1.14621217
52MP0005310_abnormal_salivary_gland1.14369481
53MP0004883_abnormal_blood_vessel1.11606970
54MP0003075_altered_response_to1.10657271
55MP0002998_abnormal_bone_remodeling1.07012266
56MP0005058_abnormal_lysosome_morphology1.04103413
57MP0000858_altered_metastatic_potential1.03808651
58MP0001851_eye_inflammation1.03755763
59MP0001986_abnormal_taste_sensitivity1.02420658
60MP0009840_abnormal_foam_cell1.01119660
61MP0009763_increased_sensitivity_to0.99568276
62MP0009765_abnormal_xenobiotic_induced0.93883851
63MP0003828_pulmonary_edema0.92952196
64MP0006054_spinal_hemorrhage0.92908073
65MP0001188_hyperpigmentation0.91960634
66MP0008004_abnormal_stomach_pH0.89030637
67MP0004381_abnormal_hair_follicle0.88792081
68MP0003806_abnormal_nucleotide_metabolis0.87728875
69MP0001853_heart_inflammation0.86668049
70MP0002019_abnormal_tumor_incidence0.83024387
71MP0002138_abnormal_hepatobiliary_system0.82926138
72MP0000343_altered_response_to0.82605249
73MP0001873_stomach_inflammation0.81712927
74MP0005390_skeleton_phenotype0.81045866
75MP0002166_altered_tumor_susceptibility0.80511922
76MP0003638_abnormal_response/metabolism_0.80455906
77MP0008873_increased_physiological_sensi0.79669891
78MP0005164_abnormal_response_to0.78951158
79MP0002006_tumorigenesis0.78863913
80MP0003448_altered_tumor_morphology0.70843388
81MP0003795_abnormal_bone_structure0.70702688
82MP0002277_abnormal_respiratory_mucosa0.68875180
83MP0000490_abnormal_crypts_of0.66971548
84MP0001663_abnormal_digestive_system0.66132020
85MP0005451_abnormal_body_composition0.63402015
86MP0008872_abnormal_physiological_respon0.61541645
87MP0000604_amyloidosis0.60936802
88MP0005670_abnormal_white_adipose0.60703105
89MP0000681_abnormal_thyroid_gland0.58667275
90MP0001764_abnormal_homeostasis0.57991764
91MP0004185_abnormal_adipocyte_glucose0.57781988
92MP0001915_intracranial_hemorrhage0.56284740
93MP0000249_abnormal_blood_vessel0.55495833
94MP0005535_abnormal_body_temperature0.54858741
95MP0002933_joint_inflammation0.54230572
96MP0005376_homeostasis/metabolism_phenot0.49227463
97MP0005084_abnormal_gallbladder_morpholo0.48749920
98MP0005319_abnormal_enzyme/_coenzyme0.47349967
99MP0001765_abnormal_ion_homeostasis0.44817177
100MP0004130_abnormal_muscle_cell0.41265315

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.60315095
2Elevated erythrocyte sedimentation rate (HP:0003565)5.49502511
3Orchitis (HP:0100796)5.18403002
4Optic neuritis (HP:0100653)4.94243458
5Retrobulbar optic neuritis (HP:0100654)4.94243458
6Eczematoid dermatitis (HP:0000976)4.93072575
7Abnormality of macrophages (HP:0004311)4.51415551
8Recurrent abscess formation (HP:0002722)4.44786995
9Stomatitis (HP:0010280)4.44644356
10Panhypogammaglobulinemia (HP:0003139)4.44039855
11Recurrent bacterial skin infections (HP:0005406)4.24895138
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.18335520
13Encephalitis (HP:0002383)4.16412104
14Meningitis (HP:0001287)4.07092264
15Agammaglobulinemia (HP:0004432)3.80334559
16Recurrent fungal infections (HP:0002841)3.72771088
17Keratoconjunctivitis sicca (HP:0001097)3.63999691
18Mediastinal lymphadenopathy (HP:0100721)3.46864314
19Chronic mucocutaneous candidiasis (HP:0002728)3.39856785
20Recurrent cutaneous fungal infections (HP:0011370)3.39856785
21Gastrointestinal infarctions (HP:0005244)3.39562552
22Keratoconjunctivitis (HP:0001096)3.39549472
23Increased IgE level (HP:0003212)3.37387455
24Obstructive lung disease (HP:0006536)3.30923051
25Chronic obstructive pulmonary disease (HP:0006510)3.30923051
26Recurrent gram-negative bacterial infections (HP:0005420)3.25409032
27Petechiae (HP:0000967)3.15901766
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.13691077
29Abnormality of glycolipid metabolism (HP:0010969)3.13691077
30Abnormality of liposaccharide metabolism (HP:0010968)3.13691077
31Prolonged bleeding time (HP:0003010)3.13381505
32Granulocytopenia (HP:0001913)3.13239748
33Recurrent skin infections (HP:0001581)3.10340308
34Acute lymphatic leukemia (HP:0006721)3.09564075
35Vasculitis (HP:0002633)3.06513182
36Recurrent viral infections (HP:0004429)2.96562822
37Abnormality of T cells (HP:0002843)2.94360220
38Urticaria (HP:0001025)2.92476961
39Autoimmune hemolytic anemia (HP:0001890)2.92119325
40T lymphocytopenia (HP:0005403)2.91488356
41Leukocytosis (HP:0001974)2.87532048
42Spontaneous hematomas (HP:0007420)2.86106063
43Severe combined immunodeficiency (HP:0004430)2.85539403
44Inflammation of the large intestine (HP:0002037)2.81454080
45Gastrointestinal inflammation (HP:0004386)2.79248121
46Abnormality of T cell number (HP:0011839)2.77218074
47Pulmonary infiltrates (HP:0002113)2.76611447
48Pustule (HP:0200039)2.72871076
49Epistaxis (HP:0000421)2.71225530
50Episodic fever (HP:0001954)2.69593910
51Abnormality of T cell physiology (HP:0011840)2.69523565
52Arterial thrombosis (HP:0004420)2.69191927
53Cellulitis (HP:0100658)2.69083154
54Amyloidosis (HP:0011034)2.68390786
55Hemoptysis (HP:0002105)2.67287951
56Chest pain (HP:0100749)2.65874903
57Dysostosis multiplex (HP:0000943)2.59478398
58Purpura (HP:0000979)2.53111266
59Pulmonary embolism (HP:0002204)2.47419291
60Fatigue (HP:0012378)2.47145636
61Alveolar cell carcinoma (HP:0006519)2.46741153
62Combined immunodeficiency (HP:0005387)2.39669475
63Colitis (HP:0002583)2.37478719
64Hepatosplenomegaly (HP:0001433)2.37475763
65Autoimmune thrombocytopenia (HP:0001973)2.37241450
66Polygenic inheritance (HP:0010982)2.36749820
67Anorexia (HP:0002039)2.36308616
68Acute myeloid leukemia (HP:0004808)2.35119144
69Gangrene (HP:0100758)2.31344058
70Gingival bleeding (HP:0000225)2.29682476
71Abnormality of B cell number (HP:0010975)2.28280693
72Osteomyelitis (HP:0002754)2.27150421
73Abnormality of the pleura (HP:0002103)2.26772558
74Acute hepatic failure (HP:0006554)2.24903110
75Neoplasm of the tracheobronchial system (HP:0100552)2.23712363
76Polyneuropathy (HP:0001271)2.22148892
77Abnormality of eosinophils (HP:0001879)2.17964641
78Eosinophilia (HP:0001880)2.14756390
79Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14629280
80Joint swelling (HP:0001386)2.13570874
81Vertigo (HP:0002321)2.13052544
82Sepsis (HP:0100806)2.06829082
83Chronic otitis media (HP:0000389)2.05644555
84Increased IgM level (HP:0003496)2.04928439
85Glomerulopathy (HP:0100820)2.03830256
86Abnormality of the pericardium (HP:0001697)2.02117417
87B lymphocytopenia (HP:0010976)2.01699972
88Hypergammaglobulinemia (HP:0010702)2.01684215
89Gingivitis (HP:0000230)2.00599647
90Acne (HP:0001061)1.99741719
91Abnormality of the prostate (HP:0008775)1.99715074
92Increased serum ferritin (HP:0003281)1.98999371
93Vacuolated lymphocytes (HP:0001922)1.98567980
94Keratitis (HP:0000491)1.96636359
95Lymphopenia (HP:0001888)1.96337593
96Systemic lupus erythematosus (HP:0002725)1.94987153
97Skin rash (HP:0000988)1.94016070
98Increased cerebral lipofuscin (HP:0011813)1.91884688
99Amaurosis fugax (HP:0100576)1.90080505
100Hypertriglyceridemia (HP:0002155)1.89884189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.15252696
2KIT3.99562530
3IRAK43.86572972
4ERN13.42382132
5RIPK43.19037377
6GRK62.75409482
7MAP2K32.62656155
8FES2.46065568
9CSF1R2.27975767
10FLT32.17727841
11TAOK32.17317165
12TXK2.14231196
13SYK2.12274639
14AKT32.07241281
15CDK191.97424683
16PRPF4B1.92017321
17JAK31.89334975
18BTK1.86047321
19MARK31.85222731
20TAF11.74791991
21TYK21.74375057
22TNK21.71731808
23ZAP701.71591421
24BLK1.63917160
25PIK3CG1.58437500
26CSK1.56202477
27TESK21.51442184
28LCK1.47078411
29MAP3K131.46673530
30HCK1.45349675
31MATK1.38590149
32MAP3K141.34533898
33SCYL21.32270553
34LYN1.28688871
35BCKDK1.27116092
36ITK1.24447987
37TEC1.23857573
38MAP3K111.22323214
39GRK71.18721464
40TBK11.18482971
41IKBKE1.18205630
42BMPR21.14225149
43MAP4K21.08947397
44PIM11.01243948
45ILK0.97944587
46STK100.97191621
47IKBKB0.95259618
48PDK10.90997468
49JAK10.90776119
50EPHB10.89759424
51BRAF0.85728971
52MAP2K60.84215756
53JAK20.83835873
54MOS0.83748686
55TGFBR20.76179467
56MAPK120.75702510
57LRRK20.75133244
58HIPK20.73480979
59PRKCQ0.71020713
60KDR0.70238411
61FGR0.68495141
62SGK20.65502896
63RPS6KA40.59939584
64CDK40.57866686
65TAOK20.57079565
66PDPK10.56339016
67ACVR1B0.53843242
68DAPK10.52378566
69RPS6KL10.49577642
70RPS6KC10.49577642
71SGK30.48620267
72ALK0.48327456
73NME20.48269232
74MAP3K30.48172528
75PRKCH0.47165383
76SIK30.44990779
77KSR10.44669665
78RPS6KA60.43730928
79MAP3K10.43384055
80YES10.42000858
81TAOK10.41474443
82FYN0.41274967
83MAP2K20.41046172
84MAPKAPK20.40296645
85PTK2B0.38321448
86IRAK10.36600385
87CDK60.35742723
88MAPK130.34313137
89STK110.33159513
90PRKD20.31520332
91PRKCD0.31468511
92MAP2K40.31068543
93MAPK40.29458272
94MAPK30.28713898
95MAPK110.28700738
96ABL10.28031646
97EGFR0.27616359
98MAPK70.27229737
99DYRK1B0.26582511
100FGFR30.25840008

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.49130099
2Allograft rejection_Homo sapiens_hsa053303.34235897
3Leishmaniasis_Homo sapiens_hsa051403.23555903
4Autoimmune thyroid disease_Homo sapiens_hsa053202.96627289
5Primary immunodeficiency_Homo sapiens_hsa053402.94307233
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.55510927
7Type I diabetes mellitus_Homo sapiens_hsa049402.54658689
8Staphylococcus aureus infection_Homo sapiens_hsa051502.52243960
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.51771156
10Asthma_Homo sapiens_hsa053102.48884199
11Antigen processing and presentation_Homo sapiens_hsa046122.38637759
12Osteoclast differentiation_Homo sapiens_hsa043802.31491296
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.26086015
14Tuberculosis_Homo sapiens_hsa051522.16741264
15B cell receptor signaling pathway_Homo sapiens_hsa046622.03073708
16Other glycan degradation_Homo sapiens_hsa005112.02640532
17Hematopoietic cell lineage_Homo sapiens_hsa046401.95966051
18Acute myeloid leukemia_Homo sapiens_hsa052211.80473913
19Viral myocarditis_Homo sapiens_hsa054161.76524704
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72752618
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66760279
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.65716740
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60091087
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53251018
25Measles_Homo sapiens_hsa051621.53240263
26Toxoplasmosis_Homo sapiens_hsa051451.49699162
27Chemokine signaling pathway_Homo sapiens_hsa040621.45900484
28T cell receptor signaling pathway_Homo sapiens_hsa046601.45178025
29Platelet activation_Homo sapiens_hsa046111.44065905
30Malaria_Homo sapiens_hsa051441.43517926
31Pertussis_Homo sapiens_hsa051331.40348155
32Rheumatoid arthritis_Homo sapiens_hsa053231.37278019
33Herpes simplex infection_Homo sapiens_hsa051681.33334332
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32831980
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.31089250
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30186401
37Regulation of autophagy_Homo sapiens_hsa041401.28969937
38Influenza A_Homo sapiens_hsa051641.28852964
39Lysosome_Homo sapiens_hsa041421.07072314
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06029288
41Shigellosis_Homo sapiens_hsa051311.05543830
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02445027
43Non-small cell lung cancer_Homo sapiens_hsa052231.01649216
44Phagosome_Homo sapiens_hsa041451.01617629
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00743870
46Legionellosis_Homo sapiens_hsa051340.98630096
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.96808613
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.91500256
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91316460
50TNF signaling pathway_Homo sapiens_hsa046680.89410645
51Apoptosis_Homo sapiens_hsa042100.83877675
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83813498
53African trypanosomiasis_Homo sapiens_hsa051430.78933292
54Hepatitis B_Homo sapiens_hsa051610.74395864
55Epstein-Barr virus infection_Homo sapiens_hsa051690.72288205
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.69813747
57VEGF signaling pathway_Homo sapiens_hsa043700.68829968
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.67980655
59Notch signaling pathway_Homo sapiens_hsa043300.66256707
60Hepatitis C_Homo sapiens_hsa051600.65595419
61Prolactin signaling pathway_Homo sapiens_hsa049170.64158301
62Arachidonic acid metabolism_Homo sapiens_hsa005900.63809314
63Salmonella infection_Homo sapiens_hsa051320.63382555
64Base excision repair_Homo sapiens_hsa034100.60858587
65HTLV-I infection_Homo sapiens_hsa051660.59855298
66Endocytosis_Homo sapiens_hsa041440.57945483
67Fatty acid elongation_Homo sapiens_hsa000620.56223414
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55925558
69Chronic myeloid leukemia_Homo sapiens_hsa052200.55700601
70Pancreatic cancer_Homo sapiens_hsa052120.54581117
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53608609
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.51900151
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.49387850
74Viral carcinogenesis_Homo sapiens_hsa052030.47085763
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45650512
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44975351
77Pentose phosphate pathway_Homo sapiens_hsa000300.44566757
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38153175
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36106757
80Renin-angiotensin system_Homo sapiens_hsa046140.35950280
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35060322
82Ribosome_Homo sapiens_hsa030100.34612549
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32589203
84mTOR signaling pathway_Homo sapiens_hsa041500.31085299
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30853275
86Systemic lupus erythematosus_Homo sapiens_hsa053220.28418766
87Amoebiasis_Homo sapiens_hsa051460.28239191
88Linoleic acid metabolism_Homo sapiens_hsa005910.26047737
89Olfactory transduction_Homo sapiens_hsa047400.24823819
90Choline metabolism in cancer_Homo sapiens_hsa052310.23996913
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.23258409
92FoxO signaling pathway_Homo sapiens_hsa040680.22031088
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21621387
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.20998776
95Phototransduction_Homo sapiens_hsa047440.20799496
96Inositol phosphate metabolism_Homo sapiens_hsa005620.19920439
97Colorectal cancer_Homo sapiens_hsa052100.19481483
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19097437
99MAPK signaling pathway_Homo sapiens_hsa040100.17683708
100Glycerolipid metabolism_Homo sapiens_hsa005610.15481116

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