SIGLEC22P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.53182493
2immunoglobulin mediated immune response (GO:0016064)6.15925568
3response to peptidoglycan (GO:0032494)6.06077732
4positive regulation of gamma-delta T cell activation (GO:0046645)5.89145920
5cellular extravasation (GO:0045123)5.48851963
6positive regulation of mast cell activation (GO:0033005)5.30277915
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.12296970
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.12296970
9modulation by symbiont of host immune response (GO:0052553)5.12296970
10positive regulation by symbiont of host defense response (GO:0052509)5.12296970
11modulation by symbiont of host defense response (GO:0052031)5.12296970
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.12296970
13B cell mediated immunity (GO:0019724)5.01135144
14positive regulation of mast cell activation involved in immune response (GO:0033008)4.95806786
15positive regulation of mast cell degranulation (GO:0043306)4.95806786
16regulation of mast cell degranulation (GO:0043304)4.84045626
17detection of other organism (GO:0098543)4.79554375
18detection of bacterium (GO:0016045)4.56565902
19macrophage activation involved in immune response (GO:0002281)4.52530939
20regulation of mast cell activation involved in immune response (GO:0033006)4.47583254
21microglial cell activation (GO:0001774)4.45568738
22regulation of myeloid leukocyte mediated immunity (GO:0002886)4.41954036
23regulation of mast cell activation (GO:0033003)4.40895105
24antigen processing and presentation of endogenous antigen (GO:0019883)4.31602940
25positive regulation of B cell differentiation (GO:0045579)4.30953695
26regulation of leukocyte degranulation (GO:0043300)4.26382220
27negative regulation of interleukin-12 production (GO:0032695)4.19312361
28neutrophil activation (GO:0042119)4.13412450
29positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.11620713
30regulation of gamma-delta T cell activation (GO:0046643)4.09455892
31respiratory burst (GO:0045730)4.06080949
32regulation of B cell receptor signaling pathway (GO:0050855)4.04753584
33myeloid cell activation involved in immune response (GO:0002275)4.02970996
34detection of external biotic stimulus (GO:0098581)3.97121697
35negative regulation of cell killing (GO:0031342)3.88285060
36negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.88285060
37positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.88126764
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85511163
39granulocyte activation (GO:0036230)3.85296177
40neutrophil mediated immunity (GO:0002446)3.85198334
41negative regulation of phagocytosis (GO:0050765)3.84574028
42response to host immune response (GO:0052572)3.80931232
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.80931232
44macrophage activation (GO:0042116)3.80506575
45positive thymic T cell selection (GO:0045059)3.79383611
46detection of molecule of bacterial origin (GO:0032490)3.75298213
47regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.74865366
48response to muramyl dipeptide (GO:0032495)3.73060649
49detection of biotic stimulus (GO:0009595)3.70505141
50regulation of antigen processing and presentation (GO:0002577)3.67885812
51regulation of dendritic cell antigen processing and presentation (GO:0002604)3.67335104
52positive regulation of antigen processing and presentation (GO:0002579)3.65697681
53regulation of hypersensitivity (GO:0002883)3.63061451
54regulation of B cell differentiation (GO:0045577)3.60416181
55regulation of regulated secretory pathway (GO:1903305)3.57377152
56interferon-gamma-mediated signaling pathway (GO:0060333)3.56903342
57negative regulation of erythrocyte differentiation (GO:0045647)3.56188721
58positive regulation of leukocyte degranulation (GO:0043302)3.55685481
59cell wall macromolecule catabolic process (GO:0016998)3.50674105
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.47389435
61response to host (GO:0075136)3.43728502
62response to host defenses (GO:0052200)3.43728502
63response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.43728502
64positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.42746659
65regulation of gamma-delta T cell differentiation (GO:0045586)3.40579697
66regulation of macrophage cytokine production (GO:0010935)3.33258136
67mature B cell differentiation involved in immune response (GO:0002313)3.27366727
68positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.26890570
69modulation of growth of symbiont involved in interaction with host (GO:0044144)3.24343378
70regulation of growth of symbiont in host (GO:0044126)3.24343378
71negative regulation of growth of symbiont in host (GO:0044130)3.24343378
72negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.24343378
73defense response to protozoan (GO:0042832)3.23155227
74positive regulation of macrophage cytokine production (GO:0060907)3.22802152
75B cell receptor signaling pathway (GO:0050853)3.21927572
76negative regulation of T cell mediated immunity (GO:0002710)3.17718722
77leukocyte degranulation (GO:0043299)3.14753571
78positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.14034774
79myeloid leukocyte mediated immunity (GO:0002444)3.10941773
80positive regulation of regulated secretory pathway (GO:1903307)3.08984410
81leukocyte aggregation (GO:0070486)3.05907484
82pinocytosis (GO:0006907)3.05369651
83response to protozoan (GO:0001562)3.03565936
84positive regulation of type 2 immune response (GO:0002830)3.02316347
85negative thymic T cell selection (GO:0045060)3.00175851
86Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97268200
87negative regulation of lymphocyte mediated immunity (GO:0002707)2.94923891
88cell wall macromolecule metabolic process (GO:0044036)2.92379048
89positive regulation of tumor necrosis factor production (GO:0032760)2.91999407
90T cell selection (GO:0045058)2.91554376
91regulation of interferon-beta biosynthetic process (GO:0045357)2.90347815
92antigen processing and presentation via MHC class Ib (GO:0002475)2.89445445
93antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87419902
94T-helper 1 type immune response (GO:0042088)2.86839098
95myeloid leukocyte activation (GO:0002274)2.85532846
96mast cell activation (GO:0045576)2.85448773
97regulation of interleukin-8 biosynthetic process (GO:0045414)2.85361509
98lipopolysaccharide-mediated signaling pathway (GO:0031663)2.85336638
99positive T cell selection (GO:0043368)2.82047309
100regulation of T-helper 2 cell differentiation (GO:0045628)2.81877813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.40927025
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.29571058
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.36339339
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.70900807
5VDR_21846776_ChIP-Seq_THP-1_Human3.61082232
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.44748193
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.28436716
8VDR_24763502_ChIP-Seq_THP-1_Human3.24094932
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.23536006
10SPI1_23547873_ChIP-Seq_NB4_Human3.12070316
11SCL_19346495_ChIP-Seq_HPC-7_Human2.95187384
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.93972426
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75926660
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.75490151
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.74452268
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.72015704
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.70420382
18SPI1_23127762_ChIP-Seq_K562_Human2.68454517
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58085832
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.50049833
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27123681
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.24210436
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23758726
24MYB_26560356_Chip-Seq_TH2_Human2.22199630
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.19097671
26MAF_26560356_Chip-Seq_TH1_Human2.13510224
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.10676274
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09269896
29VDR_24787735_ChIP-Seq_THP-1_Human2.04826854
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03506597
31UTX_26944678_Chip-Seq_JUKART_Human2.01778504
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.00936598
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98618126
34MYC_22102868_ChIP-Seq_BL_Human1.98459511
35MYB_26560356_Chip-Seq_TH1_Human1.92887232
36RUNX_20019798_ChIP-Seq_JUKART_Human1.91530468
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90033985
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86940555
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86769926
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80091962
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.76597088
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69064590
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68491896
44CIITA_25753668_ChIP-Seq_RAJI_Human1.58367809
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53375490
46GATA3_27048872_Chip-Seq_THYMUS_Human1.53098231
47MAF_26560356_Chip-Seq_TH2_Human1.49909890
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45918116
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41788048
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39789467
51GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37022450
52TCF7_22412390_ChIP-Seq_EML_Mouse1.36390910
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34970900
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33410222
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33035305
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.32524215
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32052235
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31466044
59KDM2B_26808549_Chip-Seq_DND41_Human1.30904809
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29182180
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28662862
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28088651
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28048712
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27914744
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27652681
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27281617
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26859214
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22715480
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22485691
70GATA3_26560356_Chip-Seq_TH2_Human1.20208248
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15254400
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13888976
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13861083
74SPI1_20517297_ChIP-Seq_HL60_Human1.13260984
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13127112
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12957052
77TFEB_21752829_ChIP-Seq_HELA_Human1.12808829
78PU_27001747_Chip-Seq_BMDM_Mouse1.12528141
79BCL6_27268052_Chip-Seq_Bcells_Human1.12458774
80RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08770982
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.08509048
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06180382
83LXR_22292898_ChIP-Seq_THP-1_Human1.06044943
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05972058
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.02794449
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01978892
87GATA1_19941826_ChIP-Seq_K562_Human0.99376544
88HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97446698
89GATA1_22025678_ChIP-Seq_K562_Human0.96572407
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91429194
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88972870
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87986176
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85964881
94SMAD_19615063_ChIP-ChIP_OVARY_Human0.85546276
95STAT1_20625510_ChIP-Seq_HELA_Human0.85174242
96BCOR_27268052_Chip-Seq_Bcells_Human0.84322667
97NCOR1_26117541_ChIP-Seq_K562_Human0.81836126
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81493773
99P300_27268052_Chip-Seq_Bcells_Human0.77558469
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75165598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.71471954
2MP0003724_increased_susceptibility_to3.86541713
3MP0003436_decreased_susceptibility_to3.70725435
4MP0002419_abnormal_innate_immunity3.34522595
5MP0003303_peritoneal_inflammation3.11889163
6MP0005058_abnormal_lysosome_morphology2.92784912
7MP0005025_abnormal_response_to2.89824363
8MP0006082_CNS_inflammation2.87935287
9MP0003172_abnormal_lysosome_physiology2.76353643
10MP0002148_abnormal_hypersensitivity_rea2.74168036
11MP0005000_abnormal_immune_tolerance2.72317543
12MP0001800_abnormal_humoral_immune2.71691073
13MP0005464_abnormal_platelet_physiology2.68673847
14MP0009785_altered_susceptibility_to2.57984640
15MP0005671_abnormal_response_to2.57508288
16MP0002452_abnormal_antigen_presenting2.53864764
17MP0002420_abnormal_adaptive_immunity2.48070456
18MP0001819_abnormal_immune_cell2.45039547
19MP0002723_abnormal_immune_serum2.44759805
20MP0001790_abnormal_immune_system2.37016392
21MP0005387_immune_system_phenotype2.37016392
22MP0003828_pulmonary_edema2.34705139
23MP0000685_abnormal_immune_system2.28197297
24MP0008260_abnormal_autophagy2.18690011
25MP0002132_abnormal_respiratory_system2.17020588
26MP0003806_abnormal_nucleotide_metabolis2.06691042
27MP0009278_abnormal_bone_marrow2.00610454
28MP0002396_abnormal_hematopoietic_system1.85947079
29MP0002398_abnormal_bone_marrow1.85506767
30MP0001533_abnormal_skeleton_physiology1.84428349
31MP0003300_gastrointestinal_ulcer1.83610616
32MP0003075_altered_response_to1.81624726
33MP0000716_abnormal_immune_system1.81624232
34MP0002166_altered_tumor_susceptibility1.76303161
35MP0002009_preneoplasia1.73188835
36MP0002405_respiratory_system_inflammati1.73104805
37MP0005451_abnormal_body_composition1.69320638
38MP0001545_abnormal_hematopoietic_system1.69168222
39MP0005397_hematopoietic_system_phenotyp1.69168222
40MP0001853_heart_inflammation1.68692870
41MP0000465_gastrointestinal_hemorrhage1.68451090
42MP0009764_decreased_sensitivity_to1.67912396
43MP0001845_abnormal_inflammatory_respons1.67087670
44MP0000858_altered_metastatic_potential1.58495823
45MP0003763_abnormal_thymus_physiology1.56296985
46MP0000689_abnormal_spleen_morphology1.55026705
47MP0002722_abnormal_immune_system1.54418651
48MP0008469_abnormal_protein_level1.53213143
49MP0010155_abnormal_intestine_physiology1.51028038
50MP0002429_abnormal_blood_cell1.50772224
51MP0008004_abnormal_stomach_pH1.47849963
52MP0003191_abnormal_cellular_cholesterol1.46809129
53MP0005166_decreased_susceptibility_to1.41809885
54MP0002998_abnormal_bone_remodeling1.41508503
55MP0004883_abnormal_blood_vessel1.33878791
56MP0004947_skin_inflammation1.29141385
57MP0003866_abnormal_defecation1.28134488
58MP0000703_abnormal_thymus_morphology1.16254229
59MP0000343_altered_response_to1.13431197
60MP0009333_abnormal_splenocyte_physiolog1.13364346
61MP0002006_tumorigenesis1.13114735
62MP0003183_abnormal_peptide_metabolism1.11069262
63MP0001851_eye_inflammation1.08711460
64MP0009763_increased_sensitivity_to0.97539433
65MP0005164_abnormal_response_to0.95427353
66MP0001986_abnormal_taste_sensitivity0.93566284
67MP0004808_abnormal_hematopoietic_stem0.93455949
68MP0003690_abnormal_glial_cell0.89071651
69MP0000604_amyloidosis0.88949021
70MP0000015_abnormal_ear_pigmentation0.88681156
71MP0005075_abnormal_melanosome_morpholog0.88288535
72MP0005390_skeleton_phenotype0.82801657
73MP0000569_abnormal_digit_pigmentation0.82582827
74MP0006036_abnormal_mitochondrial_physio0.82385990
75MP0003656_abnormal_erythrocyte_physiolo0.82323117
76MP0003448_altered_tumor_morphology0.82155533
77MP0004510_myositis0.81377633
78MP0005319_abnormal_enzyme/_coenzyme0.72993163
79MP0004381_abnormal_hair_follicle0.71768986
80MP0005165_increased_susceptibility_to0.70441497
81MP0009840_abnormal_foam_cell0.70236406
82MP0005174_abnormal_tail_pigmentation0.69529791
83MP0001663_abnormal_digestive_system0.68810538
84MP0005310_abnormal_salivary_gland0.68747982
85MP0002019_abnormal_tumor_incidence0.68177620
86MP0000490_abnormal_crypts_of0.65531025
87MP0001873_stomach_inflammation0.64073845
88MP0000249_abnormal_blood_vessel0.63241100
89MP0003795_abnormal_bone_structure0.61562499
90MP0009765_abnormal_xenobiotic_induced0.60929925
91MP0005647_abnormal_sex_gland0.60571558
92MP0000920_abnormal_myelination0.58887977
93MP0002933_joint_inflammation0.51860110
94MP0005076_abnormal_cell_differentiation0.49301595
95MP0005376_homeostasis/metabolism_phenot0.48856594
96MP0005084_abnormal_gallbladder_morpholo0.48755334
97MP0008873_increased_physiological_sensi0.48474172
98MP0005334_abnormal_fat_pad0.47697661
99MP0009115_abnormal_fat_cell0.46926225
100MP0000470_abnormal_stomach_morphology0.45475980

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.94325217
2Recurrent bacterial skin infections (HP:0005406)5.88790274
3Eczematoid dermatitis (HP:0000976)5.10867299
4Abnormality of macrophages (HP:0004311)5.02802064
5Obstructive lung disease (HP:0006536)4.76565738
6Chronic obstructive pulmonary disease (HP:0006510)4.76565738
7Increased cerebral lipofuscin (HP:0011813)4.59349428
8Elevated erythrocyte sedimentation rate (HP:0003565)4.58372124
9Recurrent gram-negative bacterial infections (HP:0005420)4.48979063
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.30610104
11Amyloidosis (HP:0011034)4.29965657
12Myositis (HP:0100614)4.23706434
13Recurrent skin infections (HP:0001581)4.13361574
14Recurrent cutaneous fungal infections (HP:0011370)4.11363283
15Chronic mucocutaneous candidiasis (HP:0002728)4.11363283
16Meningitis (HP:0001287)4.10579561
17Stomatitis (HP:0010280)3.94922346
18Recurrent fungal infections (HP:0002841)3.94872785
19Mediastinal lymphadenopathy (HP:0100721)3.89449872
20Abnormality of liposaccharide metabolism (HP:0010968)3.75859010
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.75859010
22Abnormality of glycolipid metabolism (HP:0010969)3.75859010
23Chest pain (HP:0100749)3.63723590
24Orchitis (HP:0100796)3.55269725
25Urticaria (HP:0001025)3.37422344
26Abnormality of the prostate (HP:0008775)3.36699637
27Hemoptysis (HP:0002105)3.36639982
28Retrobulbar optic neuritis (HP:0100654)3.34332064
29Optic neuritis (HP:0100653)3.34332064
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.29586142
31Thrombocytosis (HP:0001894)3.28090772
32Epistaxis (HP:0000421)3.22302524
33Pulmonary infiltrates (HP:0002113)3.22293520
34Vasculitis (HP:0002633)3.18524049
35Petechiae (HP:0000967)3.16917483
36Prolonged bleeding time (HP:0003010)3.16824731
37Gastrointestinal infarctions (HP:0005244)3.11478762
38Granulocytopenia (HP:0001913)3.10096297
39Encephalitis (HP:0002383)3.00937060
40Panhypogammaglobulinemia (HP:0003139)2.97030246
41Gingival bleeding (HP:0000225)2.92052933
42Agammaglobulinemia (HP:0004432)2.89595130
43Recurrent viral infections (HP:0004429)2.83481918
44Gingivitis (HP:0000230)2.83418498
45Spontaneous hematomas (HP:0007420)2.83170318
46Leukocytosis (HP:0001974)2.77502385
47Colitis (HP:0002583)2.77387163
48Cellulitis (HP:0100658)2.76947191
49Inflammation of the large intestine (HP:0002037)2.74280445
50Gastrointestinal inflammation (HP:0004386)2.70117464
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.66465527
52Dysostosis multiplex (HP:0000943)2.66263039
53Abnormality of the pleura (HP:0002103)2.61998121
54Gangrene (HP:0100758)2.59192370
55Purpura (HP:0000979)2.59092463
56Pulmonary embolism (HP:0002204)2.57606096
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.50419714
58Skin rash (HP:0000988)2.48623347
59Keratoconjunctivitis sicca (HP:0001097)2.45720970
60Arterial thrombosis (HP:0004420)2.44114316
61Fatigue (HP:0012378)2.43805098
62Osteomyelitis (HP:0002754)2.40932107
63Polyneuropathy (HP:0001271)2.39958158
64Increased serum ferritin (HP:0003281)2.39157932
65Eosinophilia (HP:0001880)2.38316791
66Increased IgE level (HP:0003212)2.38165023
67Loss of speech (HP:0002371)2.37562352
68Hepatosplenomegaly (HP:0001433)2.35173382
69Vacuolated lymphocytes (HP:0001922)2.30807141
70Keratoconjunctivitis (HP:0001096)2.28595469
71Amaurosis fugax (HP:0100576)2.24481619
72Thoracic kyphosis (HP:0002942)2.21796089
73Episodic fever (HP:0001954)2.21031813
74Polygenic inheritance (HP:0010982)2.19624182
75Skin ulcer (HP:0200042)2.17156755
76Increased IgM level (HP:0003496)2.16046958
77Abnormality of male internal genitalia (HP:0000022)2.15029188
78Abnormality of T cell physiology (HP:0011840)2.11882371
79Restrictive lung disease (HP:0002091)2.11315427
80Thrombophlebitis (HP:0004418)2.11113448
81Glomerulopathy (HP:0100820)2.10308088
82Abnormality of T cells (HP:0002843)2.08683590
83Mutism (HP:0002300)2.03198386
84Abnormality of the columella (HP:0009929)2.03084483
85Ureteral stenosis (HP:0000071)2.03054247
86Abnormality of polysaccharide metabolism (HP:0011012)2.02876637
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02876637
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02876637
89Pulmonary fibrosis (HP:0002206)2.02355920
90Abnormality of iron homeostasis (HP:0011031)2.01938972
91Basal ganglia calcification (HP:0002135)2.01271529
92Autoimmune thrombocytopenia (HP:0001973)2.01228404
93Sepsis (HP:0100806)1.99758885
94Centrally nucleated skeletal muscle fibers (HP:0003687)1.99176722
95Pustule (HP:0200039)1.96593311
96Ureteral obstruction (HP:0006000)1.96473409
97Vertigo (HP:0002321)1.95489742
98Abnormality of the peritoneum (HP:0002585)1.94536094
99Anorexia (HP:0002039)1.94386600
100Cerebral ischemia (HP:0002637)1.92497057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.22499231
2BLK3.77073031
3FES3.16918586
4MAP4K12.97877896
5TYK22.90239859
6MAP2K32.61677860
7KIT2.53237265
8IRAK42.47178746
9ERN12.46871524
10BMPR22.35941497
11CSF1R2.32704732
12MAP3K142.28984174
13BTK2.23496323
14ZAP702.14862858
15SYK2.13866550
16TNK22.07161231
17CSK1.96542397
18PRPF4B1.92185816
19JAK31.83530059
20GRK61.79308934
21TESK21.74234124
22TEC1.67356008
23HCK1.61312345
24TBK11.58684848
25LYN1.53980489
26MAP3K131.52421571
27TXK1.50438864
28IKBKE1.46662998
29PIK3CG1.45196238
30FGR1.43663767
31MARK31.38670768
32MAP3K31.37631421
33FLT31.35595734
34KDR1.31533435
35RPS6KA41.30836250
36JAK21.21052430
37LCK1.20618014
38TAOK31.16162145
39MAPK121.14014292
40MAP3K111.12405113
41ITK1.12314546
42MATK1.11274780
43JAK11.04603467
44MAP3K11.04521947
45IKBKB1.01992046
46PINK10.93130543
47IRAK20.87662860
48MOS0.84842742
49PDK10.82889077
50MAPK70.82261928
51PDPK10.77847993
52CDK190.75534821
53PRKCQ0.73515099
54RPS6KL10.73177647
55RPS6KC10.73177647
56NME20.72059824
57YES10.66366793
58STK100.66176559
59ARAF0.61339650
60RPS6KA60.60792790
61MAP3K50.60021439
62MAP3K70.57356126
63GRK70.57290674
64TRPM70.55646838
65MAP3K60.55386010
66TAOK10.54345381
67RPS6KA20.50346291
68CDK60.49874485
69TGFBR20.49039734
70MAP2K20.48378019
71KSR20.46391237
72IRAK30.45542347
73TAOK20.44783443
74LRRK20.42946052
75FYN0.42077976
76IRAK10.41826387
77ABL10.41373005
78MARK20.37611168
79EGFR0.37094057
80RPS6KA10.36593801
81CDK40.33940168
82PIM10.32795620
83PRKCD0.32599347
84MAPKAPK20.31290892
85RAF10.30196628
86MAPK40.30035221
87HIPK20.29656542
88PAK10.29341167
89SCYL20.28944473
90CAMK40.26617659
91CLK10.26156378
92RPS6KA50.25826007
93PRKD10.25811407
94CDC42BPA0.25771559
95MAP3K80.25238280
96MAPK110.24807576
97TTN0.24619032
98CCNB10.24222712
99ABL20.23680434
100SGK30.23675909

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.53021357
2Allograft rejection_Homo sapiens_hsa053303.76208416
3Graft-versus-host disease_Homo sapiens_hsa053323.69209124
4Leishmaniasis_Homo sapiens_hsa051403.59021080
5Staphylococcus aureus infection_Homo sapiens_hsa051503.57215617
6Autoimmune thyroid disease_Homo sapiens_hsa053203.52451087
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.06084802
8Type I diabetes mellitus_Homo sapiens_hsa049402.98872839
9Antigen processing and presentation_Homo sapiens_hsa046122.52998090
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.46885395
11Viral myocarditis_Homo sapiens_hsa054162.43520794
12Tuberculosis_Homo sapiens_hsa051522.41589749
13Osteoclast differentiation_Homo sapiens_hsa043802.40097693
14Rheumatoid arthritis_Homo sapiens_hsa053232.16308106
15Hematopoietic cell lineage_Homo sapiens_hsa046402.11060325
16B cell receptor signaling pathway_Homo sapiens_hsa046621.90810994
17Other glycan degradation_Homo sapiens_hsa005111.76709721
18Phagosome_Homo sapiens_hsa041451.73466151
19Toxoplasmosis_Homo sapiens_hsa051451.72559324
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70390114
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65752524
22Influenza A_Homo sapiens_hsa051641.58710630
23Herpes simplex infection_Homo sapiens_hsa051681.56263969
24Primary immunodeficiency_Homo sapiens_hsa053401.49735444
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.44093833
26Legionellosis_Homo sapiens_hsa051341.43727789
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42851566
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41897463
29Lysosome_Homo sapiens_hsa041421.35143728
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34112723
31Pertussis_Homo sapiens_hsa051331.26939949
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.24327237
33Malaria_Homo sapiens_hsa051441.22607393
34Platelet activation_Homo sapiens_hsa046111.16418510
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12678202
36Acute myeloid leukemia_Homo sapiens_hsa052211.12140822
37Measles_Homo sapiens_hsa051621.07044926
38Chemokine signaling pathway_Homo sapiens_hsa040620.99640972
39T cell receptor signaling pathway_Homo sapiens_hsa046600.98636109
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97492548
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93173540
42Systemic lupus erythematosus_Homo sapiens_hsa053220.92759495
43Shigellosis_Homo sapiens_hsa051310.92698251
44Regulation of autophagy_Homo sapiens_hsa041400.92268660
45Salmonella infection_Homo sapiens_hsa051320.91177277
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.80245472
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79945744
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76020922
49TNF signaling pathway_Homo sapiens_hsa046680.73107188
50Hepatitis B_Homo sapiens_hsa051610.72880247
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71107393
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.69973457
53Epstein-Barr virus infection_Homo sapiens_hsa051690.69905724
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58849475
55Non-small cell lung cancer_Homo sapiens_hsa052230.57747797
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57609930
57Apoptosis_Homo sapiens_hsa042100.54843200
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52738352
59Pancreatic cancer_Homo sapiens_hsa052120.52606712
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.51382757
61African trypanosomiasis_Homo sapiens_hsa051430.51382219
62HTLV-I infection_Homo sapiens_hsa051660.51308071
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44807172
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42831686
65Hepatitis C_Homo sapiens_hsa051600.42001834
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39653939
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.36915897
68Amoebiasis_Homo sapiens_hsa051460.36567334
69VEGF signaling pathway_Homo sapiens_hsa043700.36526408
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33869702
71Pentose phosphate pathway_Homo sapiens_hsa000300.33591356
72Collecting duct acid secretion_Homo sapiens_hsa049660.31496532
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30903899
74Chronic myeloid leukemia_Homo sapiens_hsa052200.30552190
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.29080784
76Viral carcinogenesis_Homo sapiens_hsa052030.26455316
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25596840
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.25443319
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24132899
80HIF-1 signaling pathway_Homo sapiens_hsa040660.23971157
81GnRH signaling pathway_Homo sapiens_hsa049120.21917101
82Endocytosis_Homo sapiens_hsa041440.21621165
83Olfactory transduction_Homo sapiens_hsa047400.21034936
84DNA replication_Homo sapiens_hsa030300.20230781
85Choline metabolism in cancer_Homo sapiens_hsa052310.17747674
86Renal cell carcinoma_Homo sapiens_hsa052110.16885793
87Arachidonic acid metabolism_Homo sapiens_hsa005900.16264953
88Prolactin signaling pathway_Homo sapiens_hsa049170.15278007
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14713560
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.14388393
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13529363
92Oxytocin signaling pathway_Homo sapiens_hsa049210.13444317
93Galactose metabolism_Homo sapiens_hsa000520.13369775
94mTOR signaling pathway_Homo sapiens_hsa041500.13255503
95FoxO signaling pathway_Homo sapiens_hsa040680.12851311
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12686131
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12097342
98MAPK signaling pathway_Homo sapiens_hsa040100.11064509
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.11037335
100Type II diabetes mellitus_Homo sapiens_hsa049300.09963212

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