SIGLECL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)8.16646432
2protein targeting to Golgi (GO:0000042)7.91344421
3establishment of protein localization to Golgi (GO:0072600)7.79865232
4retrograde transport, vesicle recycling within Golgi (GO:0000301)7.43316974
5protein polyglutamylation (GO:0018095)7.29501288
6spermatid development (GO:0007286)7.21061933
7multicellular organism reproduction (GO:0032504)7.14204261
8sperm-egg recognition (GO:0035036)7.11171794
9sperm capacitation (GO:0048240)7.05050034
10rRNA methylation (GO:0031167)6.82389959
11microtubule depolymerization (GO:0007019)6.57709842
12chromosome condensation (GO:0030261)6.28774545
13single strand break repair (GO:0000012)6.19628036
14reproduction (GO:0000003)6.14611815
15DNA packaging (GO:0006323)6.13267748
16binding of sperm to zona pellucida (GO:0007339)6.07753281
17microtubule severing (GO:0051013)6.00442937
18cilium or flagellum-dependent cell motility (GO:0001539)5.93232250
19phosphatidylethanolamine biosynthetic process (GO:0006646)5.91951723
20calcium ion-dependent exocytosis (GO:0017156)5.90741558
21cell-cell recognition (GO:0009988)5.89739788
22rRNA modification (GO:0000154)5.85703141
23microtubule polymerization or depolymerization (GO:0031109)5.80104439
24spermatid nucleus differentiation (GO:0007289)5.72480150
25axonemal dynein complex assembly (GO:0070286)5.71945128
26regulation of cilium movement (GO:0003352)5.71679566
27protein localization to Golgi apparatus (GO:0034067)5.63818484
28spermatogenesis (GO:0007283)5.56229743
29male gamete generation (GO:0048232)5.54293806
30response to pheromone (GO:0019236)5.53766704
31cell wall macromolecule catabolic process (GO:0016998)5.53334836
32phosphatidylethanolamine metabolic process (GO:0046337)5.49007543
33centriole replication (GO:0007099)5.17540166
34gamete generation (GO:0007276)5.12827809
35single fertilization (GO:0007338)5.03882791
36cell wall macromolecule metabolic process (GO:0044036)4.94644121
37negative regulation of inclusion body assembly (GO:0090084)4.79369833
38epithelial cilium movement (GO:0003351)4.68589985
39cellular ketone body metabolic process (GO:0046950)4.50988459
40regulation of centriole replication (GO:0046599)4.46890077
41motile cilium assembly (GO:0044458)4.42360496
42RNA destabilization (GO:0050779)4.40016362
43centriole assembly (GO:0098534)4.36405104
44sexual reproduction (GO:0019953)4.34856013
45cilium movement (GO:0003341)4.26344741
46fertilization (GO:0009566)4.26090608
47multicellular organismal movement (GO:0050879)4.21216659
48musculoskeletal movement (GO:0050881)4.21216659
49seminiferous tubule development (GO:0072520)4.17272123
50multicellular organismal reproductive process (GO:0048609)4.06921940
51positive regulation of Rab GTPase activity (GO:0032851)4.01882119
52regulation of Rab GTPase activity (GO:0032313)4.01882119
53glomerular visceral epithelial cell development (GO:0072015)4.01084851
54germ cell development (GO:0007281)3.97399956
55ketone body metabolic process (GO:1902224)3.95109421
56positive regulation of guanylate cyclase activity (GO:0031284)3.94344211
57retinal cone cell development (GO:0046549)3.89157390
58regulation of microtubule-based movement (GO:0060632)3.85187306
59microtubule nucleation (GO:0007020)3.83285568
60glomerular epithelial cell development (GO:0072310)3.72403656
61cellular process involved in reproduction in multicellular organism (GO:0022412)3.71995780
62regulation of inclusion body assembly (GO:0090083)3.65809804
63cerebral cortex radially oriented cell migration (GO:0021799)3.62949961
64regulation of acrosome reaction (GO:0060046)3.59759158
65regulation of guanylate cyclase activity (GO:0031282)3.57384923
66regulation of establishment of cell polarity (GO:2000114)3.57226372
67membrane protein intracellular domain proteolysis (GO:0031293)3.51897209
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23168723
69parturition (GO:0007567)3.14530514
70nucleus organization (GO:0006997)3.13745264
71organic cation transport (GO:0015695)3.13572257
72intra-Golgi vesicle-mediated transport (GO:0006891)3.10985716
73detection of light stimulus involved in sensory perception (GO:0050962)3.10767288
74detection of light stimulus involved in visual perception (GO:0050908)3.10767288
75axoneme assembly (GO:0035082)3.00660187
76coenzyme catabolic process (GO:0009109)2.99693623
77cell recognition (GO:0008037)2.97740801
78ventricular system development (GO:0021591)2.96679314
79polyamine biosynthetic process (GO:0006596)2.91522381
80cellular response to pH (GO:0071467)2.90468170
81regulation of establishment or maintenance of cell polarity (GO:0032878)2.87762670
82cilium assembly (GO:0042384)2.87633914
83chromatin silencing (GO:0006342)2.85488939
84detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.84217305
85cilium organization (GO:0044782)2.83091957
86male meiosis I (GO:0007141)2.75351723
87regulation of transcription involved in cell fate commitment (GO:0060850)2.73699637
88piRNA metabolic process (GO:0034587)2.73677860
89male meiosis (GO:0007140)2.73403029
90microtubule bundle formation (GO:0001578)2.69801371
91opioid receptor signaling pathway (GO:0038003)2.68034144
92multicellular organismal development (GO:0007275)2.67587993
93cerebral cortex neuron differentiation (GO:0021895)2.64622973
94embryonic viscerocranium morphogenesis (GO:0048703)2.62478139
95glycerol ether metabolic process (GO:0006662)2.61647716
96cAMP catabolic process (GO:0006198)2.61129796
97peptidyl-glutamic acid modification (GO:0018200)2.57245209
98acrosome reaction (GO:0007340)10.9786771
99fusion of sperm to egg plasma membrane (GO:0007342)10.8383588
100sperm motility (GO:0030317)10.6277544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.44659411
2FUS_26573619_Chip-Seq_HEK293_Human2.68930973
3VDR_22108803_ChIP-Seq_LS180_Human2.58145907
4CTBP1_25329375_ChIP-Seq_LNCAP_Human2.53584231
5EZH2_22144423_ChIP-Seq_EOC_Human2.49748249
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.49516719
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.38375510
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38375510
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.34347059
10CBP_20019798_ChIP-Seq_JUKART_Human2.34347059
11ZNF274_21170338_ChIP-Seq_K562_Hela2.32820516
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14158467
13UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.99340761
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.96154992
15P300_19829295_ChIP-Seq_ESCs_Human1.92936832
16ER_23166858_ChIP-Seq_MCF-7_Human1.88294711
17DROSHA_22980978_ChIP-Seq_HELA_Human1.84017764
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79672810
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76225794
20SMAD4_21799915_ChIP-Seq_A2780_Human1.70281467
21TAF15_26573619_Chip-Seq_HEK293_Human1.68184464
22SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64093326
23IRF1_19129219_ChIP-ChIP_H3396_Human1.61166577
24TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58302300
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.58162391
26AR_25329375_ChIP-Seq_VCAP_Human1.58100124
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56661261
28SMAD4_21741376_ChIP-Seq_EPCs_Human1.54136269
29STAT3_23295773_ChIP-Seq_U87_Human1.53567682
30GBX2_23144817_ChIP-Seq_PC3_Human1.53401110
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52911705
32ERG_20517297_ChIP-Seq_VCAP_Human1.51148918
33VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.49570196
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49315305
35MYC_19829295_ChIP-Seq_ESCs_Human1.49193778
36AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48433025
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46775786
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.46211101
39RAC3_21632823_ChIP-Seq_H3396_Human1.45659199
40EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.45517948
41TAF2_19829295_ChIP-Seq_ESCs_Human1.45473587
42PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.45455541
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.41039851
44FOXA1_21572438_ChIP-Seq_LNCaP_Human1.40946727
45NANOG_20526341_ChIP-Seq_ESCs_Human1.38606632
46CBX2_22325352_ChIP-Seq_293T-Rex_Human1.36670829
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36585869
48SOX2_19829295_ChIP-Seq_ESCs_Human1.36285701
49NANOG_19829295_ChIP-Seq_ESCs_Human1.36285701
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35407736
51RUNX2_22187159_ChIP-Seq_PCA_Human1.34599177
52ETV1_20927104_ChIP-Seq_GIST48_Human1.33155599
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31615861
54IGF1R_20145208_ChIP-Seq_DFB_Human1.30707390
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.30185931
56ERA_21632823_ChIP-Seq_H3396_Human1.29113211
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28439608
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.28439608
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27114627
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.26905892
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26576400
62RBPJ_21746931_ChIP-Seq_IB4_Human1.25877993
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.25873910
64TBL1_22424771_ChIP-Seq_293T_Human1.25122620
65SALL4_22934838_ChIP-ChIP_CD34+_Human1.23386842
66TCF4_23295773_ChIP-Seq_U87_Human1.23279632
67NFYB_21822215_ChIP-Seq_K562_Human1.22575348
68HNFA_21074721_ChIP-Seq_CACO-2_Human1.22549656
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.22226544
70KDM2B_26808549_Chip-Seq_REH_Human1.21858568
71P53_21459846_ChIP-Seq_SAOS-2_Human1.21719823
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20929991
73PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.18201854
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.17353903
75PHF8_20622853_ChIP-Seq_HELA_Human1.15861646
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15820696
77TP53_18474530_ChIP-ChIP_U2OS_Human1.14193738
78WDR5_24793694_ChIP-Seq_LNCAP_Human1.14105158
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13705376
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13477293
81CDX2_22108803_ChIP-Seq_LS180_Human1.13465716
82OCT1_27270436_Chip-Seq_PROSTATE_Human1.13049410
83SMAD3_21741376_ChIP-Seq_ESCs_Human1.12779628
84SMRT_27268052_Chip-Seq_Bcells_Human1.10943349
85CEBPB_22108803_ChIP-Seq_LS180_Human1.10720017
86VDR_24787735_ChIP-Seq_THP-1_Human1.10485905
87OCT4_20526341_ChIP-Seq_ESCs_Human1.10150945
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09852065
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08657291
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07163553
91NFYA_21822215_ChIP-Seq_K562_Human1.06644291
92SMAD4_21741376_ChIP-Seq_HESCs_Human1.04727364
93KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04444265
94TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.04340485
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.04077089
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03563876
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03479176
98GATA6_21074721_ChIP-Seq_CACO-2_Human1.02471801
99HOXB7_26014856_ChIP-Seq_BT474_Human1.01796350
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01205703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.51528716
2MP0005377_hearing/vestibular/ear_phenot5.19817896
3MP0003878_abnormal_ear_physiology5.19817896
4MP0005670_abnormal_white_adipose3.68025071
5MP0003698_abnormal_male_reproductive3.58911551
6MP0002102_abnormal_ear_morphology3.06829908
7MP0002653_abnormal_ependyma_morphology2.99786108
8MP0001929_abnormal_gametogenesis2.97634624
9MP0003011_delayed_dark_adaptation2.83732965
10MP0001348_abnormal_lacrimal_gland2.75432190
11MP0005379_endocrine/exocrine_gland_phen2.71327879
12MP0003646_muscle_fatigue2.23845413
13MP0005551_abnormal_eye_electrophysiolog2.12038448
14MP0006292_abnormal_olfactory_placode2.11749980
15MP0001486_abnormal_startle_reflex2.07070612
16MP0002138_abnormal_hepatobiliary_system2.04243002
17MP0003718_maternal_effect1.88104518
18MP0001485_abnormal_pinna_reflex1.85061499
19MP0005253_abnormal_eye_physiology1.80177060
20MP0000678_abnormal_parathyroid_gland1.78378304
21MP0002161_abnormal_fertility/fecundity1.76886164
22MP0008877_abnormal_DNA_methylation1.72728176
23MP0005310_abnormal_salivary_gland1.67545338
24MP0005647_abnormal_sex_gland1.62918843
25MP0002234_abnormal_pharynx_morphology1.59750285
26MP0002132_abnormal_respiratory_system1.49719009
27MP0002210_abnormal_sex_determination1.40480191
28MP0000026_abnormal_inner_ear1.32720536
29MP0000383_abnormal_hair_follicle1.27689325
30MP0005084_abnormal_gallbladder_morpholo1.27475724
31MP0008789_abnormal_olfactory_epithelium1.25232741
32MP0003880_abnormal_central_pattern1.24707361
33MP0001145_abnormal_male_reproductive1.21928979
34MP0005167_abnormal_blood-brain_barrier1.21787547
35MP0000653_abnormal_sex_gland1.20087247
36MP0001963_abnormal_hearing_physiology1.18918857
37MP0002928_abnormal_bile_duct1.17242831
38MP0001968_abnormal_touch/_nociception1.16060478
39MP0009053_abnormal_anal_canal1.14342617
40MP0009697_abnormal_copulation1.11178974
41MP0000049_abnormal_middle_ear1.10983290
42MP0008569_lethality_at_weaning1.10705664
43MP0003879_abnormal_hair_cell1.09717946
44MP0002229_neurodegeneration1.07488172
45MP0002282_abnormal_trachea_morphology1.06495583
46MP0002638_abnormal_pupillary_reflex1.04957086
47MP0000427_abnormal_hair_cycle1.02057600
48MP0005248_abnormal_Harderian_gland1.01366465
49MP0002735_abnormal_chemical_nociception0.99883879
50MP0003136_yellow_coat_color0.99405071
51MP0003632_abnormal_nervous_system0.97828564
52MP0001661_extended_life_span0.96526775
53MP0002736_abnormal_nociception_after0.95630899
54MP0001501_abnormal_sleep_pattern0.93977489
55MP0004859_abnormal_synaptic_plasticity0.92418649
56MP0001919_abnormal_reproductive_system0.87425571
57MP0001765_abnormal_ion_homeostasis0.87180925
58MP0005395_other_phenotype0.86985824
59MP0003252_abnormal_bile_duct0.86413263
60MP0002572_abnormal_emotion/affect_behav0.81072009
61MP0005423_abnormal_somatic_nervous0.80903977
62MP0001984_abnormal_olfaction0.80572900
63MP0005499_abnormal_olfactory_system0.79529735
64MP0005394_taste/olfaction_phenotype0.79529735
65MP0000955_abnormal_spinal_cord0.78023385
66MP0001270_distended_abdomen0.77663089
67MP0002127_abnormal_cardiovascular_syste0.77230337
68MP0003195_calcinosis0.76614573
69MP0000778_abnormal_nervous_system0.74117070
70MP0005391_vision/eye_phenotype0.74017787
71MP0008995_early_reproductive_senescence0.73294570
72MP0002067_abnormal_sensory_capabilities0.73061686
73MP0005365_abnormal_bile_salt0.72677886
74MP0005636_abnormal_mineral_homeostasis0.71526252
75MP0003950_abnormal_plasma_membrane0.71252925
76MP0006276_abnormal_autonomic_nervous0.70440003
77MP0003631_nervous_system_phenotype0.68425351
78MP0004742_abnormal_vestibular_system0.67795852
79MP0009745_abnormal_behavioral_response0.66895518
80MP0008875_abnormal_xenobiotic_pharmacok0.65512570
81MP0000230_abnormal_systemic_arterial0.64929671
82MP0002752_abnormal_somatic_nervous0.62543236
83MP0001970_abnormal_pain_threshold0.61053143
84MP0003635_abnormal_synaptic_transmissio0.59105380
85MP0002557_abnormal_social/conspecific_i0.56430491
86MP0005195_abnormal_posterior_eye0.54877247
87MP0001905_abnormal_dopamine_level0.54443761
88MP0002272_abnormal_nervous_system0.53913630
89MP0005085_abnormal_gallbladder_physiolo0.53263379
90MP0010678_abnormal_skin_adnexa0.52960785
91MP0005595_abnormal_vascular_smooth0.52865244
92MP0005645_abnormal_hypothalamus_physiol0.52514191
93MP0000534_abnormal_ureter_morphology0.51806330
94MP0003183_abnormal_peptide_metabolism0.51724743
95MP0002733_abnormal_thermal_nociception0.51716839
96MP0002095_abnormal_skin_pigmentation0.50267010
97MP0009764_decreased_sensitivity_to0.50017477
98MP0005397_hematopoietic_system_phenotyp0.49302335
99MP0001545_abnormal_hematopoietic_system0.49302335
100MP0004085_abnormal_heartbeat0.49020957

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)7.21952105
2Attenuation of retinal blood vessels (HP:0007843)5.65535929
3Chronic hepatic failure (HP:0100626)5.56387949
4Severe visual impairment (HP:0001141)5.52201818
5Absent/shortened dynein arms (HP:0200106)5.52036494
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.52036494
7Abnormal ciliary motility (HP:0012262)4.63453096
8Abnormality of macular pigmentation (HP:0008002)4.60501478
9Abnormal respiratory motile cilium physiology (HP:0012261)4.19584459
10Nephronophthisis (HP:0000090)4.07341721
11Asymmetric septal hypertrophy (HP:0001670)4.03663891
12Bony spicule pigmentary retinopathy (HP:0007737)3.95249362
13Abnormal rod and cone electroretinograms (HP:0008323)3.91637173
14Abnormal respiratory motile cilium morphology (HP:0005938)3.82286316
15Abnormal respiratory epithelium morphology (HP:0012253)3.82286316
16Cone-rod dystrophy (HP:0000548)3.78087552
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.76987114
18Hyperkalemia (HP:0002153)3.73736704
19Abnormality of the renal medulla (HP:0100957)3.72966510
20Decreased central vision (HP:0007663)3.54753369
21Cerebellar dysplasia (HP:0007033)3.43149753
22Nasal polyposis (HP:0100582)3.20329340
23Stage 5 chronic kidney disease (HP:0003774)3.19062563
24Tubulointerstitial abnormality (HP:0001969)3.11301581
25Hypoplasia of the thymus (HP:0000778)2.97898004
26Pancreatic fibrosis (HP:0100732)2.97760200
27True hermaphroditism (HP:0010459)2.97429537
28Amelogenesis imperfecta (HP:0000705)2.91984241
29Infertility (HP:0000789)2.91177479
30Hypoalphalipoproteinemia (HP:0003233)2.87110768
31Polydipsia (HP:0001959)2.83013102
32Abnormal drinking behavior (HP:0030082)2.83013102
33Portal hypertension (HP:0001409)2.81380806
34Congenital hepatic fibrosis (HP:0002612)2.80955817
35Atonic seizures (HP:0010819)2.78631924
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.72096058
37Progressive sensorineural hearing impairment (HP:0000408)2.69701429
38Abnormality of dental color (HP:0011073)2.68768905
39Pancreatic cysts (HP:0001737)2.66339471
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.66180346
41Abnormality of the hepatic vasculature (HP:0006707)2.56842896
42Abnormality of the nasal mucosa (HP:0000433)2.55496503
43Hypoplastic ischia (HP:0003175)2.49883703
44Male infertility (HP:0003251)2.49760681
45Pendular nystagmus (HP:0012043)2.48843451
46Molar tooth sign on MRI (HP:0002419)2.45137055
47Abnormality of midbrain morphology (HP:0002418)2.45137055
48Generalized aminoaciduria (HP:0002909)2.44155520
49Intellectual disability, moderate (HP:0002342)2.40814300
50Abnormal spermatogenesis (HP:0008669)2.40258823
51Potter facies (HP:0002009)2.37283251
52Facial shape deformation (HP:0011334)2.37283251
53Focal segmental glomerulosclerosis (HP:0000097)2.35525689
54Abnormal urine output (HP:0012590)2.33220836
55Abnormality of the parathyroid morphology (HP:0011766)2.31956239
56Rhinitis (HP:0012384)2.31531080
57Mixed hearing impairment (HP:0000410)2.27615180
58Abnormality of the renal cortex (HP:0011035)2.27154916
59Aplasia/Hypoplasia of the earlobes (HP:0009906)2.24370329
60Renal dysplasia (HP:0000110)2.24333691
61Keratoconus (HP:0000563)2.24306567
62Increased corneal curvature (HP:0100692)2.24306567
63Abnormality of potassium homeostasis (HP:0011042)2.20904294
64Abnormality of the ischium (HP:0003174)2.20740782
65Scotoma (HP:0000575)2.19176362
66Progressive cerebellar ataxia (HP:0002073)2.17689794
67Postural instability (HP:0002172)2.16889342
68Hypophosphatemic rickets (HP:0004912)2.16327469
69Polyuria (HP:0000103)2.14987735
70Resting tremor (HP:0002322)2.14320152
71Photophobia (HP:0000613)2.14291191
72Insulin-resistant diabetes mellitus (HP:0000831)2.10994415
73Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10972735
74Enlarged epiphyses (HP:0010580)2.08381676
75Azoospermia (HP:0000027)2.04873426
76Cystic liver disease (HP:0006706)2.03124508
77Flat capital femoral epiphysis (HP:0003370)2.03040525
78Truncal obesity (HP:0001956)2.02498966
79Abnormality of renal excretion (HP:0011036)1.96884489
80Optic nerve hypoplasia (HP:0000609)1.96374465
81Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.94901498
82Absent epiphyses (HP:0010577)1.94901498
83Hypoalbuminemia (HP:0003073)1.92536409
84Abnormal albumin level (HP:0012116)1.92536409
85Tubular atrophy (HP:0000092)1.92278782
86Congenital sensorineural hearing impairment (HP:0008527)1.91223657
87Abnormality of the costochondral junction (HP:0000919)1.88990924
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88516878
89Abnormality of the epiphysis of the femoral head (HP:0010574)1.88019010
90Renal cortical cysts (HP:0000803)1.86407199
91Myokymia (HP:0002411)1.85833614
92Sclerocornea (HP:0000647)1.85031083
93Partial agenesis of the corpus callosum (HP:0001338)1.84054024
94Menstrual irregularities (HP:0000858)1.81790537
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79712355
96Constricted visual fields (HP:0001133)1.79213064
97Occipital encephalocele (HP:0002085)1.79205109
98Anencephaly (HP:0002323)1.78457918
99Hypertriglyceridemia (HP:0002155)1.76432441
100Febrile seizures (HP:0002373)1.74019372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.65769238
2INSRR5.44982564
3BRD45.07619275
4LATS13.50242370
5PBK3.12209809
6MAP4K22.99738790
7PLK22.89122473
8PDK22.79222472
9PRKD32.69944302
10NUAK12.38891019
11TESK12.33129363
12STK382.02655252
13ADRBK21.97277571
14CAMK1G1.95061975
15DDR21.94702294
16NEK61.93213475
17PNCK1.91433170
18PTK2B1.87818868
19CDK191.86182452
20MAP3K41.81746553
21PIK3CG1.54956107
22BMPR1B1.52302768
23FRK1.52266879
24STK38L1.44371733
25MAP2K71.39527636
26EPHA41.37159588
27PDK11.29048283
28PDPK11.26818527
29MAPK151.18082888
30PINK11.01067177
31CAMK1D0.96971506
32WNK40.95580713
33ACVR1B0.89407415
34TIE10.88503477
35WNK30.84297703
36TYRO30.81604996
37WNK10.81567631
38MAP3K60.73922152
39STK30.70863688
40PRKG20.70144305
41PRKG10.68122882
42STK390.65230820
43SIK20.64854287
44DYRK1B0.62059149
45JAK30.57588774
46CAMK10.57488884
47MAP3K110.54607735
48MAP2K20.54269406
49PRKCQ0.53592279
50MUSK0.48523479
51PRKAA20.47649231
52DYRK20.46606081
53MARK10.45704429
54NTRK20.44084449
55RPS6KA20.43179622
56CDK70.42724423
57PRKCG0.40475384
58MST1R0.40245896
59MAPK130.40195609
60NEK20.40124446
61CDK30.38703926
62DMPK0.38158017
63RPS6KA10.37519039
64TGFBR10.35873648
65RPS6KA60.34933563
66MAPK70.34485189
67AKT30.33972164
68SGK20.33292892
69SGK2230.33212632
70SGK4940.33212632
71PRKACA0.32787612
72TNIK0.32466410
73MATK0.31411935
74MAP3K70.29112819
75RPS6KC10.28006041
76RPS6KL10.28006041
77CSNK1D0.26544032
78CAMK40.25388505
79MAP2K40.25283012
80MKNK20.24906573
81ROCK10.24418934
82MAPK10.23024896
83PRKCE0.22238223
84GSK3B0.21865563
85CAMK2A0.21400033
86MKNK10.21311100
87BRSK10.21172282
88PKN10.20140699
89NTRK30.20073396
90MAP2K10.19725685
91PRKAA10.19639003
92OXSR10.18613627
93ZAK0.17279314
94TRPM70.16587393
95PRKACG0.16437100
96UHMK10.16315784
97MET0.16219938
98BLK0.16108675
99MAPK80.15915707
100CDK10.15716994

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.61356477
2Fatty acid biosynthesis_Homo sapiens_hsa000615.28394985
3Olfactory transduction_Homo sapiens_hsa047404.00626694
4Phototransduction_Homo sapiens_hsa047443.34397544
5Butanoate metabolism_Homo sapiens_hsa006502.70371800
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.70262899
7Taste transduction_Homo sapiens_hsa047422.68303398
8Nitrogen metabolism_Homo sapiens_hsa009102.40768085
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90981082
10Glycerophospholipid metabolism_Homo sapiens_hsa005641.89397000
11Linoleic acid metabolism_Homo sapiens_hsa005911.76387501
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74988447
13Dorso-ventral axis formation_Homo sapiens_hsa043201.69253680
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64486749
15Serotonergic synapse_Homo sapiens_hsa047261.62098935
16ABC transporters_Homo sapiens_hsa020101.57398365
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57114730
18Morphine addiction_Homo sapiens_hsa050321.44694106
19Fatty acid metabolism_Homo sapiens_hsa012121.35693396
20Retinol metabolism_Homo sapiens_hsa008301.26032570
21Fatty acid degradation_Homo sapiens_hsa000711.25716640
22Salivary secretion_Homo sapiens_hsa049701.24482738
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24369985
24Calcium signaling pathway_Homo sapiens_hsa040201.20988051
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13523713
26PPAR signaling pathway_Homo sapiens_hsa033201.12578123
27RNA transport_Homo sapiens_hsa030131.10815945
28Chemical carcinogenesis_Homo sapiens_hsa052041.08336584
29Circadian entrainment_Homo sapiens_hsa047131.07802134
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.07531397
31Glycerolipid metabolism_Homo sapiens_hsa005611.02651495
32Tryptophan metabolism_Homo sapiens_hsa003801.01418777
33cAMP signaling pathway_Homo sapiens_hsa040241.00565187
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98599440
35Vascular smooth muscle contraction_Homo sapiens_hsa042700.96336271
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93117460
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92453727
38Sulfur relay system_Homo sapiens_hsa041220.91280316
39Glutamatergic synapse_Homo sapiens_hsa047240.90747429
40Nicotine addiction_Homo sapiens_hsa050330.90267364
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90227790
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87927213
43Phenylalanine metabolism_Homo sapiens_hsa003600.86434654
44Pancreatic secretion_Homo sapiens_hsa049720.85883566
45Adipocytokine signaling pathway_Homo sapiens_hsa049200.85612564
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85549705
47Propanoate metabolism_Homo sapiens_hsa006400.83806667
48Caffeine metabolism_Homo sapiens_hsa002320.82548268
49Hedgehog signaling pathway_Homo sapiens_hsa043400.82153313
50Inositol phosphate metabolism_Homo sapiens_hsa005620.78873243
51Cardiac muscle contraction_Homo sapiens_hsa042600.76528313
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.76482431
53Arachidonic acid metabolism_Homo sapiens_hsa005900.74379598
54Long-term depression_Homo sapiens_hsa047300.72897226
55Fat digestion and absorption_Homo sapiens_hsa049750.72248982
56RNA polymerase_Homo sapiens_hsa030200.70059317
57Type II diabetes mellitus_Homo sapiens_hsa049300.69889493
58beta-Alanine metabolism_Homo sapiens_hsa004100.67648846
59Huntingtons disease_Homo sapiens_hsa050160.62488030
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60157748
61Renin-angiotensin system_Homo sapiens_hsa046140.60081816
62Bile secretion_Homo sapiens_hsa049760.59902087
63Renin secretion_Homo sapiens_hsa049240.58529002
64Purine metabolism_Homo sapiens_hsa002300.58206850
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57270370
66Ether lipid metabolism_Homo sapiens_hsa005650.56356409
67Insulin secretion_Homo sapiens_hsa049110.54975199
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52430671
69Platelet activation_Homo sapiens_hsa046110.52327716
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49530720
71Fanconi anemia pathway_Homo sapiens_hsa034600.48167360
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48000878
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.47653219
74Cholinergic synapse_Homo sapiens_hsa047250.47469330
75Gastric acid secretion_Homo sapiens_hsa049710.47171030
76Basal transcription factors_Homo sapiens_hsa030220.46667878
77Oxytocin signaling pathway_Homo sapiens_hsa049210.44897992
78GABAergic synapse_Homo sapiens_hsa047270.44414189
79Protein digestion and absorption_Homo sapiens_hsa049740.44213963
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43469880
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42198794
82MAPK signaling pathway_Homo sapiens_hsa040100.38550941
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38330563
84Oocyte meiosis_Homo sapiens_hsa041140.36976165
85Tyrosine metabolism_Homo sapiens_hsa003500.36453495
86Metabolic pathways_Homo sapiens_hsa011000.36129118
87Synaptic vesicle cycle_Homo sapiens_hsa047210.34134939
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31944761
89Long-term potentiation_Homo sapiens_hsa047200.31824691
90Choline metabolism in cancer_Homo sapiens_hsa052310.29546573
91Arginine and proline metabolism_Homo sapiens_hsa003300.29279253
92Autoimmune thyroid disease_Homo sapiens_hsa053200.28728118
93Graft-versus-host disease_Homo sapiens_hsa053320.28726147
94Fatty acid elongation_Homo sapiens_hsa000620.27909532
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27664407
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.26513587
97Regulation of autophagy_Homo sapiens_hsa041400.26293779
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24420401
99Ovarian steroidogenesis_Homo sapiens_hsa049130.24263279
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24092630

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